Papers - UCHIYAMA Yoshikazu
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A micro-disc-based multiplex method for monitoring emerging SARS-CoV-2 variants using the molecular diagnostic tool Intelli-OVI Reviewed
M.B.Hossain, Y.Uchiyama, S.A.Rajib, A.Rahman, M.Takatori, B.J.Y. Tan, K.Sugata, M.Nagashima, M.Kawakami, H.Ito, R.Kumagai, K.Sadamasu, Y.Ogi, T.Kawaguchi, T.Tamura, T.Fukuhara, M.Ono, K.Yoshimura, Y.Satou
Communications Medicine 4 ( 161 ) 2024.8
Language：English Publishing type：Research paper (scientific journal)
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Feasibility of direct brain 18F-fluorodeoxyglucose-positron emission tomography attenuation and high-resolution correction methods using deep learning Reviewed
Tomohiro Ueda, Kousuke Yamshita, Retsu Kawazoe, Yuta Sayawaki, Yoshiki Morisawa, Ryosuke Kamezaki, Ryuji Ikeda, Shinya Shiraishi, Yoshikazu Uchiyama, Shigeki Ito
Asia Oceania Journal of Nuclear Medicine and Biology 2024.7
Publishing type：Research paper (scientific journal)
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Development of an automated region-of-interest-setting method based on a deep neural network for brain perfusion single photon emission computed tomography quantification methods Reviewed
Taeko Tomimatsu, Kousuke Yamshita, Takumi Sakata, Ryosuke Kamezaki, Ryuji Ikeda, Shinya Shiraishi, Yoshikazu Uchiyama, Shigeki Ito
Asia Oceania Journal of Nuclear Medicine and Biology 2024.7
Publishing type：Research paper (scientific journal)
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主成分回帰を用いたアルツハイマー関連遺伝子の型と脳萎縮パターンの関係を抽出するための画像データマイニング Reviewed
谷口美桜，畑中あすか，甲斐千遥，内山良一
医用画像情報学会雑誌 41 ( 2 ) 41 - 45 2024.6
Authorship：Corresponding author Publishing type：Research paper (scientific journal)
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Radiomicsの再整理と新たなる可能性 Invited
内山良一
医用画像情報学会雑誌 41 ( 2 ) 37 - 40 2024.6
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Feasibility of deep convolution neural network-based automatic time activity curve fitting method for non-invasive cerebral blood flow quantification Reviewed
Reiko Nagaoka, Kosuke Yamashita, Naohiro Yabusa, Ryosuke Kamezaki, Ryuji Ikeda, Shinya Shiraishi, Yoshikazu Uchiyama, Shigeki Ito
Radiation Safety Management 22 7 - 17 2023.12
Publishing type：Research paper (scientific journal)
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精密医療のための Radiogenomics と Radioproteomics Invited
内山良一
医用画像情報学会雑誌 40 ( 4 ) 85 - 87 2023.12
Authorship：Lead author Publishing type：Research paper (scientific journal)
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乳がんの免疫チェックポイント分子の活性と不活性を判別するためのRadioproteomics Reviewed
原田芙優, 福田徹, 内山良一
日本放射線技術学会雑誌 79 ( 10 ) 1136 - 1143 2023.8
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Radioproteomicsによる乳がんのホルモン受容体の陽性と陰性の判別 Reviewed
原田芙優, 福田徹, 内山良一
医用画像情報学会雑誌 40 ( 1 ) 1 - 6 2023.3
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Prediction of COVID-19 patients in danger of death using radiomic features of portable chest radiographs Reviewed
Maoko Nakashima, Yoshikazu Uchiyama, Hirotake Minami, Satoshi Kasai
Journal of Medical Radiation Science 70 ( 1 ) 13 - 20 2023.3
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1002/jmrs.631
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乳がんのRadiogenomics Invited
内山良一
Medical Imaging Technology 41 ( 2 ) 67 - 72 2023.3
Authorship：Lead author Publishing type：Research paper (scientific journal)
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Movements of Ancient Human Endogenous Retroviruses Detected in SOX2-Expressing Cells Reviewed
Kazuaki Monde, Yorifumi Satou, Mizuki Goto, Yoshikazu Uchiyama, Jumpei Ito, Taku Kaitsuka, Hiromi Terasawa, Nami Monde, Shinya Yamaga, Tomoya Matsusako, Fan-Yan Wei, Ituro Inoue, Kazuhito Tomizawa, Akira Ono, Takumi Era, Tomohiro Sawa, Yosuke Maeda
Journal of Virology Apr 14 2022.4
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1128/jvi.00356-22
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乳腺・脳MR画像を用いた個別化医療ナビゲーションシステム Invited
内山良一
日本放射線技術学会雑誌 78 ( 4 ) 395 - 399 2022.4
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
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Prediction of pathological complete response using radiomics on MRI in patients with breast cancer undergoing neoadjuvant pharmacotherapy Reviewed
Yuka Kuramoto, Natsumi Wada, Yoshikazu Uchiyama
International Journal of Computer Assisted Radiology and Surgery 17 ( 4 ) 619 - 625 2022.4
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Radiomicsにおける意思決定支援のためのデータ可視化技術 Reviewed
平野菜奈恵, 内山良一
医用画像情報学会雑誌 39 ( 1 ) 1 - 6 2022.1
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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肺がんのRadiomics研究 Invited
内山良一
医用画像情報学会雑誌 38 ( 2 ) 59 - 60 2021
Publishing type：Research paper (scientific journal)
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生存時間分析におけるRadiomics特徴量の比例ハザード性 Reviewed
和田菜摘美, 岸本奈渚子, 内山良一
医用画像情報学会雑誌 38 ( 1 ) 15 - 20 2021
Publishing type：Research paper (scientific journal)
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Radiomicsを用いた非小細胞肺がんのEGFR遺伝子変異の推定 -遺伝子発現パターンの違いが表現型に及ぼす影響- Reviewed
藏本裕香, 内山良一
医用画像情報学会雑誌 38 ( 3 ) 137 - 142 2021
Publishing type：Research paper (scientific journal)
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Radiomicsによる生存時間解析を用いた肺がん患者の再発リスクの推定 Reviewed
吉岡拓弥, 内山良一, 白石順二
日本放射線技術学会雑誌 77 ( 2 ) 153 - 159 2021
Publishing type：Research paper (scientific journal)
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HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma Reviewed International journal
BJY. Tan, K. Sugata, O. Reda, M. Matsuo, K. Uchiyama, P. Miyazato, V. Hahaut, M. Yamagishi, K. Uchimaru, Y. Suzuki, T. Ueno, H. Suzushima, H. Katsuya, M. Tokunaga, Y. Uchiyama, H. Nakamura, E. Sueoka, A. Utsunomiya, M. Ono, Y. Satou
The Journal of Clinical Investigation 131 ( 24 ) e15042 2021
Publishing type：Research paper (scientific journal)
Human T cell leukemia virus type 1 (HTLV-1) mainly infects CD4+ T cells and induces chronic, persistent infection in infected individuals, with some developing adult T cell leukemia/lymphoma (ATL). HTLV-1 alters cellular differentiation, activation, and survival; however, it is unknown whether and how these changes contribute to the malignant transformation of infected cells. In this study, we used single-cell RNA-sequencing and T cell receptor-sequencing to investigate the differentiation and HTLV-1-mediated transformation of T cells. We analyzed 87,742 PBMCs from 12 infected and 3 uninfected individuals. Using multiple independent bioinformatics methods, we demonstrated the seamless transition of naive T cells into activated T cells, whereby HTLV-1-infected cells in an activated state further transformed into ATL cells, which are characterized as clonally expanded, highly activated T cells. Notably, the greater the activation state of ATL cells, the more they acquire Treg signatures. Intriguingly, the expression of HLA class II genes in HTLV-1-infected cells was uniquely induced by the viral protein Tax and further upregulated in ATL cells. Functional assays revealed that HTLV-1-infected cells upregulated HLA class II molecules and acted as tolerogenic antigen-presenting cells to induce anergy of antigen-specific T cells. In conclusion, our study revealed the in vivo mechanisms of HTLV-1-mediated transformation and immune escape at the single-cell level.
DOI： 10.1172/JCI150472