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• Local treatment for metastatic and primary sites in metastatic renal cell carcinoma in the combination immunotherapy era: a narrative review 査読あり

  Abe J., Murashima T., Kojima S., Ueno T., Takei A., Nakai N., Akioka T., Kamoto T., Sawada A.

  International Journal of Clinical Oncology   2026年2月

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  掲載種別：研究論文（学術雑誌）   出版者・発行元：International Journal of Clinical Oncology  

  Advances in immuno-oncology (IO)-based systemic therapies have improved treatment outcomes for patients with metastatic renal cell carcinoma (mRCC). However, long-term survival of these patients remains challenging, highlighting the need to reassess the role of local and metastasis-directed treatments. Cytoreductive nephrectomy (CN) has traditionally been a part of the therapeutic armamentarium for mRCC, and evidence from the targeted therapy era—most notably the CARMENA and SURTIME trials—indicates that deferred CN after initial systemic therapy may benefit carefully selected patients. In the IO era, prospective evidence regarding CN is lacking, although ongoing trials, such as NORDIC-SUN and PROBE, are expected to refine patient selection and optimal timing. Real-world analysis reveals a significant decline in conducting CN since 2018. However, CN remains associated with improved overall survival of patients who received several IO-based first-line regimens after adjustment for baseline characteristics. Metastasis-directed treatments, including metastasectomy and local interventions for bone metastases, continue to exhibit potential survival benefits and may maintain functional status when complete resection of lesions is achievable. Considering the absence of definitive prospective data applicable to routine clinical practice, individualized treatment strategies should consider CN and local therapies alongside systemic treatment response, tumor biology, and patient-specific prognostic factors.

  DOI： 10.1007/s10147-026-02982-8

  Scopus

• 膀胱拡大術なしに下部尿路機能を回復し得た高度膀胱変形を呈した先天性後部尿道弁の1例 査読あり

  植野尭

  日本泌尿器科学会雑誌   116 ( 3 )   91 - 95   2025年7月

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  担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

• Metastasis of malignant melanoma to urinary tract: a case report 査読あり

  Takashi Ueno

  J Med Case Rep.   28　18（1） ( 396 )   2024年8月

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  担当区分：筆頭著者   掲載種別：症例報告