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医学部 医学科 感覚運動医学講座皮膚科学分野 |
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教授 |
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関連SDGs |
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論文 【 表示 ／ 非表示 】
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巻頭言 おかれた場所で咲く 査読あり
緒方 大
皮膚科の臨床 68 ( 4 ) 393 - 394 2026年4月
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Efficacy and safety of pazopanib in patients with paclitaxel-pretreated primary cutaneous angiosarcoma in Japan: Results of the Japan Clinical Oncology Group single-arm confirmatory trial (JCOG1605). 査読あり
Oashi K, Ogata D, Yokoyama M, Sano Y, Fukuda H, Hiura A, Nakamura Y, Uehara J, Takahashi A, Namikawa K, Mori S, Nakano E, Maeda T, Miyagawa T, Yoshino K, Funakoshi T, Kiniwa Y, Nakagawa T, Shibayama Y, Uchi H, Maeda T, Muto I, Maruyama A, Takenouchi T, Hatta N, Yamazaki N
The British journal of dermatology 2026年3月
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2．リンパ節へのアプローチ 査読あり
緒方 大
日本皮膚科学会雑誌 136 ( 2 ) 113 - 116 2026年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本皮膚科学会
皮膚がんは皮膚のあらゆる部位に発生しうるため，皮膚がん領域で外科治療の対象となるリンパ節領域は頸部・腋窩・鼠径・骨盤と広い範囲に及ぶが，リンパ節へアプローチする手技は，基本的な結紮・切離・剝離操作の応用で対応が可能である．本稿では主に，骨盤内領域におけるリンパ節郭清術の手順や実際の手技について概説する．
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Ishiguro A, Ogata D, Ishiyama K, Oguma J, Kurita D, Nakano E, Namikawa K, Takahashi A, Daiko H, Seto Y, Yamazaki N
The Journal of dermatology 53 ( 2 ) 264 - 272 2026年2月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Dermatology
Primary malignant melanoma of the esophagus (PMME) accounts for only 0.5% of all melanomas but is associated with the shortest interval to disease progression and the highest metastasis rate. The optimal treatment for PMME remains elusive. The present study aimed to assess the utility of screening as a means of predicting the prognosis of PMME and to determine the efficacy of surgery and immune checkpoint inhibitors (ICIs) against this disease. Fifty-two patients with PMME treated at the National Cancer Center Hospital in Japan between 2010 and 2023 were enrolled. Survival analysis was performed for (i) patients with PMME (n = 52); (ii) resectable cases at the initial presentation (n = 36); and (iii) cases with systemic therapy (n = 37). The 5-year overall survival (OS) rate was 45.0%, and the median OS was 55.8 months. The 5-year OS rate of the patients in whom PMME was detected by screening and those in whom it was diagnosed clinically was 54.7% and 40.1%, respectively (p = 0.255). The presence of a lymph node metastasis was associated with a significantly higher recurrence and poorer prognosis. The 3-year RFS rate of the patients at the local and nodal stage was 57.8% and 6.9%, respectively (p < 0.0001). At surgery, the rate of lymph node metastasis in the recurrence group and the nonrecurrence group was 68% and 10%, respectively (p = 0.0027). In the patients who received ICI therapy, the 3-year OS was 33.3%, the median OS was 15.0 months, and the overall response rate was 23.5%. Our findings suggested that ICI therapy may improve survival in patients with advanced PMME. However, further research is warranted to identify both the clinical and molecular predictors of the treatment response as a means of improving patient selection.
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Seshimo H, Mae K, Ishiguro A, Irisawa R, Zama T, Ogata D, Harada K
The Journal of dermatology 53 ( 2 ) e139 - e140 2026年2月
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
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神経皮膚症候群および色素性乾皮症・ポルフィリン症の学際的診療体制に基づく医療 最適化と患者 QOL 向上のための研究
研究課題/領域番号：23FC1037 2023年04月 - 2026年03月
厚生労働省 厚生科研 難治性疾患政策研究事業
担当区分：研究分担者
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悪性黒色腫におけるALDH2遺伝子多型の発症と予後に関する影響の解明
研究課題/領域番号：21K16218 2021年04月 - 2027年03月
独立行政法人日本学術振興会 科学研究費基金 若手研究
担当区分：研究代表者