|
Affiliation |
Faculty of Medicine School of Medicine Department of Clinical Neuroscience, Psychiatry |
|
Title |
Assistant Professor |
|
Contact information |
|
|
Related SDGs |
|
NAKAO Shuhei
|
|
|
Papers 【 display / non-display 】
-
Nakao S., Kogoh Y., Funahashi H., Yanoma Y., Azuma M., Ishida Y., Hirano Y.
Psychiatry and Clinical Neurosciences Reports 5 ( 2 ) 2026.4
Authorship：Lead author Language：English Publishing type：Case report Publisher：Psychiatry and Clinical Neurosciences Reports
Background: Clinicians encounter considerable challenges in the diagnosis and treatment of organophosphate-induced toxic parkinsonism following acute poisoning. Here, we report the importance of longitudinal evaluation of a patient with organophosphate-induced toxic parkinsonism using dopamine transporter single-photon emission computed tomography (DAT-SPECT). This case may provide crucial insights into the pathophysiology of the syndrome and inform therapeutic decision-making. Case Presentation: We report a case of organophosphate-induced toxic parkinsonism with persistent parkinsonian symptoms evaluated longitudinally using DAT-SPECT. A 68-year-old woman with a history of bipolar disorder was found collapsed at home on Day 0 with impaired consciousness, miosis, hypersalivation, and bradycardia. Organophosphate poisoning was diagnosed based on markedly reduced cholinesterase levels and the presence of an organophosphate pesticide in a shed at her home. Parkinsonian symptoms gradually emerged from Day 18, including hypophonia and a gait disturbance. On Day 60, DAT-SPECT showed reduced radiotracer uptake in the bilateral striatum, more pronounced on the right. After toxic parkinsonism was diagnosed, l-dopa was titrated up to 600 mg/day without clinical benefit and discontinued due to adverse effects. Treatment with amantadine and trihexyphenidyl was then initiated, resulting in partial symptomatic improvement, although symptoms persisted. Despite clinical improvement, follow-up DAT-SPECT on Day 131 showed a further reduction in striatal tracer uptake, whereas quantitative improvement was observed on Day 200. Conclusion: Parkinsonism is an uncommon sequela of organophosphate poisoning and may be accompanied by abnormal DAT-SPECT findings. Moreover, amantadine and trihexyphenidyl may represent effective therapeutic options for this condition.
DOI： 10.1002/pcn5.70333
Presentations 【 display / non-display 】
-
有機リン化合物による中毒性パーキンソン症候群のドパミントランスポーターシンチグラフィ所見
中尾周平, 古郷央一郎, 船橋英樹, 平野羊嗣, 石田康
第120回日本精神神経学会学術総会 2024.6.21
Event date： 2024.6.20 - 2024.6.22
Language：Japanese Presentation type：Oral presentation (general)
-
著しいアカシジアが出現した躁状態の血液透析患者の一例
中尾周平, 石本明実, 船橋英樹, 石田康
第74回九州精神神経学会・第67回九州精神医療学会 2022.11.24
Event date： 2022.11.24 - 2022.11.25
Language：Japanese Presentation type：Oral presentation (general)
-
抗MDA5抗体，抗ARS抗体が共陽性であった皮膚筋炎/間質性肺炎の症例
中尾周平, 岩尾浩昭, 川口剛, 梅北邦彦, 宮崎泰可
第336回日本内科学会九州地方会 2022.1.29
Event date： 2022.1.29
Language：Japanese Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
-
第120回日本精神神経学会学術総会 優秀発表賞(精神科専門医研修中の医師による演題)
2024.6 日本精神神経学会 有機リン化合物による中毒性パーキンソン症候群のドパミントランスポーターシンチグラフィ所見
中尾周平, 古郷央一郎, 船橋英樹, 平野羊嗣, 石田康
Award type：Award from Japanese society, conference, symposium, etc.