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Affiliation |
Faculty of Medicine School of Medicine Oncopathology and morphopathology |
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Professor |
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External Link |
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SATO Yuichiro
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Degree 【 display / non-display 】
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Doctor (Medicine) ( 1997.3 Miyazaki Medical College )
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医学士 ( 1991.3 宮崎医科大学 )
Papers 【 display / non-display 】
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Association between fetal vascular malperfusion and gestational diabetes Reviewed
Goto T., Sato Y., Kodama Y., Tomimori K., Sameshima H., Aman M., Maekawa K., Yamashita A., Asada Y.
Journal of Obstetrics and Gynaecology Research 48 ( 1 ) 80 - 86 2022.1
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
Aim: Diabetes mellitus (DM) is a major complication in pregnancy. Placental lesions with DM remain unclear and controversial. Recently, the terms of placental pathological findings, such as maternal and fetal vascular malperfusions (MVM and FVM, respectively) were introduced by the Amsterdam Placental Workshop Group Consensus Statement (APWGCS). FVM cases were classified as the partial obstruction type (global FVM) and the complete obstruction type (segmental FVM). The aim of this study was to clarify the pathological characteristics of the placenta with pregestational DM/gestational DM; GDM according to APWGCS. Methods: We studied the placentas of 182 DM women (27 pregestational DM and 155 GDM) and control placentas of 460 women without DM during 2011–2018. We excluded cases of intrauterine fetal death or multiple pregnancies. We reviewed microscopical findings including, MVM, FVM, chorioamnionitis with the slides according to the APWGCS. Results: Microscopically, the incidence of FVM was significantly higher in GDM patients than control (17% vs. 10%, p = 0.0138), but not significant in pregestational DM (11%, p = 0.7410). Segmental FVM (complete obstruction) was significantly more observed in GDM than control group (5% vs. 0.4%, p = 0.0013). Segmental FVM in GDM showed high incidence of light-for-dates infant (three of seven cases, 43%, p = 0.0288). In addition, several segmental FVM findings (villous stromal-vascular karyorrhexis and stem vessel occlusion) were frequently noted in 2 or 3 points positive of 75 g oral glucose tolerance test than 1 point positive GDM. Conclusion: Our placental findings suggest disorder of carbohydrate metabolism might affect the fetal vascular damage, especially complete fetal vascular obstruction.
DOI： 10.1111/jog.15046
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子宮内膜細胞診におけるOsaki Study Group (OSG) 式判定の有用性 Reviewed
白濱 幸生, 佐藤 勇一郎, 清山 和昭, 野口 裕史, 林 透, 肥後 貴史
日本臨床細胞学会雑誌 60 ( 5 ) 253 - 259 2021.9
Language：Japanese Publishing type：Research paper (scientific journal)
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Gi T., Yamashita A., Aman M., Kuwahara A., Asada Y., Kawagoe Y., Onishi J., Sameshima H., Sato Y.
Pathology International 71 ( 4 ) 261 - 266 2021.4
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Pathology International
Ovarian cancer is a known risk factor of venous thromboembolism (VTE). Thrombogenic factor expression and lymphocytic infiltrate have been reported in endometriosis and ovarian cancers. We reviewed 30 cases of ovarian carcinomas (high grade serous carcinoma, 10; endometrioid carcinoma, 10; clear cell carcinoma (CCC), 10) and 16 endometriotic lesions. We immunohistochemically investigated the expressions of tissue factor (TF), podoplanin, P-selectin, and number of CD4 and CD8 positive lymphocytes in cancer tissue and endometriotic lesions, along with their relationship with VTE. The expression of TF was higher in CCC. The TF expression and the number of CD8 positive cells were higher in cancer tissues with VTE than in those without VTE. The podoplanin or P-selectin expression did not differ among histological types or between cases with and without VTE. Our results demonstrated a high TF expression and intraepithelial CD8 cells in CCC, which were associated with VTE. The results suggest that infiltrating lymphocytes may affect TF expression that, in turn, influences VTE.
DOI： 10.1111/pin.13074
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Inflammatory lesions in placental pathology Invited Reviewed
Sato Y.
Journal of Obstetrics and Gynaecology Research 48 ( 1 ) 58 - 65 2021
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
Placental inflammatory lesions are important findings that lead fetal and neonatal morbidity and mortality, and can be divided into two broad subcategories, acute inflammation caused by microorganisms and chronic inflammation caused by host immune responses. Recently, a diagnostic framework for these lesions has been established, and uniform diagnostic criteria have been recommended by the Amsterdam International Consensus Group. Chorioamnionitis is representative of the acute inflammatory lesion, and is the most frequent pathological diagnosis in placental pathology. The hallmark of chorioamnionitis is neutrophil infiltration in the membrane/chorioamnionic plate and fetal vessels. The inflammatory response can be both maternal (inflammation in the membrane or chorioamnionic plate) and fetal (inflammation in the fetal vessels—umbilical vessels or chorionic vessel). Recent studies have shown that the fetal inflammatory response is associated with neonatal mortality and morbidity. Furthermore, chronic inflammatory lesions, such as villitis of unknown etiology and chronic histiocytic intervillositis, are also important. Although their etiology remains unknown, the maternal immune response against paternal antigens has been considered a possible factor. These inflammatory lesions are associated with fetal demise and fetal growth restriction. Inflammatory lesions in the placenta are useful for understanding intrauterine conditions, guiding treatment, and predicting complications.
DOI： 10.1111/jog.14932
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Sato Y., Aman M., Maekawa K., Yamashita A., Kodama Y., Doi K., Sameshima H., Asada Y.
Virchows Archiv 477 ( 1 ) 65 - 71 2020.7
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Virchows Archiv
Pathologically diagnosed placenta accreta is defined as villi adjacent to the myometrium without decidua. It is classified into the superficial (placental accreta vera [PAV]) and deep invasive (placenta increta [PI] and placenta percreta [PP]) types. Data on the clinicopathological characteristics of PAV are limited. Basal plate myometrium (BPMYO) is found in PAV or placentas in asymptomatic women, but its significance is still controversial. This retrospective study aimed to determine the clinicopathological characteristics of pathologically diagnosed PAV and the significance of BPMYO. We reviewed 84 cases of pathologically diagnosed placenta accreta (PAV, 54; PI, 16; and PP, 14), and compared them with controls (i.e., not pathologically diagnosed of any type of placenta accreta, n = 51). Among the PAV cases, the incidence of in vitro fertilization was high, while that of previous cesarean section or placenta previa was low. The incidence of maternal complications was also high in pathologically diagnosed PAV cases, but some PAV were asymptomatic. The rate of prenatal diagnosis of PAV was low, and a high proportion of patients required emergency transportation to central hospitals. Histologically, BPMYO was found in 7 (14%) of controls and 54 (100%) of PAV cases. PAV cases had a higher rate of advanced stages of BPMYO, larger muscle tissue, and more foci than controls. In conclusion, almost PAV is a clinically symptomatic condition but has distinct risk factors and clinical findings from advanced type placenta accreta. Histological evaluation of BPMYO is useful for the diagnosis of PAV.
Books 【 display / non-display 】
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胎盤病理アトラス = Atlas of placental pathology
南口 早智子, 佐藤 勇一郎（ Role： Joint editor）
文光堂 2021 （ ISBN:9784830604843 ）
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Placental pathology. In; Preterm Labor and Delivery.
Sato Y（ Role： Contributor , Placental pathology. In; Preterm Labor and Delivery.）
Springer 2019
Language：English Book type：Scholarly book
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泌尿器病理診断アトラス 臨床と病理の対話で学ぶ
向井尚一郎、賀本敏行、佐藤勇一郎（ Role： Contributor）
総合医学社 2021.9
Language：Japanese Book type：Scholarly book
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頸部腺癌と体部腺癌の鑑別 腫瘍病理鑑別アトラス 子宮頸癌 第2版
佐藤勇一郎（ Role： Sole author）
文光堂 2018
Language：Japanese Book type：Scholarly book
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病理診断プラクティス 婦人科腫瘍
佐藤 勇一郎（ Role： Sole author , 6）
中山書店 2015.12
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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Inflammatory lesions in placental pathology Invited Reviewed
Yuichiro Sato
J Obstet Gynaecol Res 2021.11
Authorship：Lead author, Corresponding author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
DOI： 10.1111/jog.14932
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胎盤I I 胎盤病理診断 応用編：原因不明の慢性絨毛炎と絨毛間炎 Reviewed
佐藤勇一郎
病理と臨床 2019.10
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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胎盤I 胎盤病理診断 基礎編：胎盤で観察される出血・出血様変化、絨毛間血栓、絨毛膜下血栓、胎盤後血腫、びまん性絨毛膜羊膜ヘモジデローシス(DCH) Reviewed
佐藤勇一郎
病理と臨床 2019.9
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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動脈硬化における血栓形成のメカニズム Invited Reviewed
佐藤勇一郎、浅田祐士郎
病理と臨床 21 ( 9 ) 707 - 713 2003.9
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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Covid-19と胎盤病理 Invited
佐藤勇一郎
病理と臨床 40 ( 8 ) 815 - 817 2022.8
Authorship：Lead author Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
Presentations 【 display / non-display 】
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胎盤病理と血栓症 Invited
佐藤 勇一郎
第57回日本周産期・新生児医学会学術集会 2021.7.11
Event date： 2021.7.11 - 2021.7.13
Language：Japanese Presentation type：Oral presentation (invited, special)
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24th International Federation of Placenta Association International conference
Sato Y, Maekawa K, Yamashita A, Asada Y, Sameshima H.
Clinicopathogical features of chronic histiocytic intervillositis.
Event date： 2018.9.21 - 2018.9.24
Language：English Presentation type：Poster presentation
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胎盤病理と血液凝固 Invited
佐藤勇一郎
第58回日本産科婦人科・新生児血液学会学術講演会
Event date： 2018.6.16
Language：Japanese Presentation type：Oral presentation (invited, special)
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加重型妊娠高血圧腎症に伴う胎盤の病理学的所見 Invited
佐藤勇一郎、前川和也、浅田祐士郎、大橋昌尚、牧洋平、鮫島浩
第38回日本妊娠高血圧学会
Event date： 2017.9.22 - 2017.9.23
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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絨毛癌の病理と臨床 Invited
佐藤勇一郎、高石清美
第59回日本婦人科腫瘍学会
Event date： 2017.7.27 - 2017.7.29
Language：Japanese Presentation type：Oral presentation (invited, special)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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がん組織における心筋特異的トロポニンT発現の病態生理学的意義
Grant number：22K08128 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
鶴田 敏博、
Authorship：Coinvestigator(s)
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胎盤血栓症における組織因子、プロテアーゼ活性化受容体の役割
Grant number：21K07775 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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アテローム血栓症におけるKalirinの関与
Grant number：26400437 2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
アテローム血栓症におけるKalirinの関与
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アテローム血栓症の発症におけるアネキシンＡ５の関与
2009.04 - 2012.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
アテローム血栓症の発症におけるアネキシンＡ５の関与
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深部静脈血栓症および肺血栓塞栓症の発症における組織因子の関与とその由来
2007.04 - 2009.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
深部静脈血栓症および肺血栓塞栓症の発症における組織因子の関与とその由来