ISHIDA Yasushi

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Clinical Neuroscience, Psychiatry

Title

Professor

External Link

Degree 【 display / non-display

  • 博士(医学) ( 1991.9   宮崎医科大学 )

  • 医学士 ( 1985.3   大分医科大学 )

Research Areas 【 display / non-display

  • Life Science / Psychiatry

  • Life Science / Neuroscience-general

  • Life Science / Neuroscience-general

 

Papers 【 display / non-display

  • Functional MHCI deficiency induces ADHD-like symptoms with increased dopamine D1 receptor expression Reviewed

    Meng H.R., Suenaga T., Edamura M., Fukuda A., Ishida Y., Nakahara D., Murakami G.

    Brain, Behavior, and Immunity   97   22 - 31   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Brain, Behavior, and Immunity  

    Inappropriate synaptic development has been proposed as a potential mechanism of neurodevelopmental disorders, including attention-deficit hyperactivity disorder (ADHD). Major histocompatibility complex class I (MHCI), an immunity-associated molecule expressed by neurons in the brain, regulates synaptic development; however, the involvement of MHCI in these disorders remains elusive. We evaluated whether functional MHCI deficiency induced by β2m−/−Tap1−/− double-knockout in mice leads to abnormalities akin to those seen in neurodevelopmental disorders. We found that functional MHCI deficiency induced locomotor hyperactivity, motor impulsivity, and attention deficits, three major symptoms of ADHD. In contrast, these mice showed normal spatial learning, behavioral flexibility, social behavior, and sensorimotor integration. In the analysis of the dopamine system, upregulation of dopamine D1 receptor (D1R) expression in the nucleus accumbens and a greater locomotor response to D1R agonist SKF 81297 were found in the functional MHCI-deficient mice. Low-dose methylphenidate, used for the treatment of ADHD patients, alleviated the three behavioral symptoms and suppressed c-Fos expression in the D1R-expressing medium spiny neurons of the mice. These findings reveal an unexpected role of MHCI in three major symptoms of ADHD and may provide a novel landmark in the pathogenesis of ADHD

    DOI: 10.1016/j.bbi.2021.05.015

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  • Roles of 5-HT<inf>3</inf> and 5-HT<inf>7</inf> receptors in acute pruriceptive processing in mice Reviewed

    Miyahara Y., Funahashi H., Haruta-Tsukamoto A., Kogoh Y., Kanemaru-Kawazoe A., Nishimori T., Ishida Y.

    European Journal of Pharmacology   911   174513   2021.11

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:European Journal of Pharmacology  

    The roles of serotonin (5-HT) and/or noradrenaline in acute pruriceptive processing have been demonstrated using antidepressants, such as milnacipran, a serotonin and noradrenaline reuptake inhibitor, and mirtazapine, a noradrenergic and specific serotonergic antidepressant; however, the involvement of 5-HT in acute pruriceptive processing has not yet been elucidated in detail. Scratching events induced by chloroquine (CQ) were attenuated by the administration of milnacipran or mirtazapine, and these effects were reversed by a treatment with ondansetron, a 5-HT3 antagonist, or SB26970, a 5-HT7 antagonist. CQ-induced scratching events were also ameliorated by the intrathecal administration of 5-HT, SR572227A and RS56812 (5-HT3 agonists), and LP211 and LP44 (5-HT7 agonists), indicating the modulation of CQ-induced scratching events by 5-HT and noradrenaline. By contrast, histamine-induced scratching events were not markedly affected by the administration of 5-HT and 5-HT7 agonists, whereas 5-HT3 agonists exerted attenuating effects. Similarly, they were not clearly reversed by the administration of the 5-HT7 antagonist, unlike a 5-HT3 antagonist. Therefore, 5-HT is involved in the attenuating effects of milnacipran and mirtazapine on CQ- and histamine-induced scratching events, and 5-HT3 and 5-HT7 receptors play different roles in pruriceptive processing induced by histamine or CQ.

    DOI: 10.1016/j.ejphar.2021.174513

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  • Time course of effects of venlafaxine on migraine and generalized pruritus in a patient with depression

    Miyahara Y., Funahashi H., Haruta-Tsukamoto A., Hidaka H., Fujimoto T., Horinouchi A., Nishimori T., Ishida Y.

    Clinical Case Reports   9 ( 11 )   e05088   2021.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Clinical Case Reports  

    Venlafaxine has potential as a therapeutic option for patients with depressive disorder, migraine, and pruritus unresponsive to antihistamines.

    DOI: 10.1002/ccr3.5088

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  • Clinical effectiveness of metacognitive training as a transdiagnostic program in routine clinical settings: A prospective, multicenter, single-group study Reviewed

    Tanoue H., Yoshinaga N., Hayashi Y., Ishikawa R., Ishigaki T., Ishida Y.

    Japan Journal of Nursing Science   18 ( 2 )   e12389   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Journal of Nursing Science  

    Aim: To evaluate the clinical effectiveness of metacognitive training (MCT) as a transdiagnostic program, on a diverse population with mental disorders in routine Japanese day-care settings. Methods: This study employed a prospective, multicenter, single-group pre-post design. Participants diagnosed with various mental disorders received 10 MCT group sessions. We set transdiagnostic outcomes to assess quality of life, global functioning, cognitive insight, and depressive symptoms. At the end of the MCT, we also evaluated participants' satisfaction with treatment. Assessments were conducted at baseline (Pre), Week 5 (Mid), Week 10 (Post), and Week 14 (follow-up: FU). Results: Thirty-four participants enrolled in the study and received MCT (schizophrenia = 22, non-schizophrenia = 12). Intent-to-treat analyses revealed significant improvements in quality of life/global functioning during the intervention period, and further improvements were observed during the follow-up (all p <.05). The Pre–FU treatment effect sizes for quality of life and global functioning were small (Hedge's g = 0.44 and 0.47, respectively). Significant improvements were also found in depressive symptoms during both the intervention and follow-up periods (all p <.05), but not in cognitive insight. Overall, participants were highly satisfied with the MCT content and format. Scores on almost all outcomes (except for depression) at each assessment point were not significantly different between the schizophrenic and non-schizophrenic sub-groups. Conclusions: Despite several limitations, mainly due to small sample size and having no control conditions, our results suggest that MCT for a diverse population with mental disorders is a potentially effective approach in improving quality of life/global functioning and other clinical outcomes in routine day-care settings.

    DOI: 10.1111/jjns.12389

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  • Differential onset time of mirtazapine on pruritus and depression in a patient receiving hemodialysis. Reviewed

    Miyahara Y, Haruta-Tsukamoto A, Funahashi H, Matsuo H, Kanemaru-Kawazoe A, Nishimori T, Ishida Y

    SAGE open medical case reports   9   2050313X20988408   2021.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/2050313X20988408

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Books 【 display / non-display

  • Influence of Prenatal Stress on Psychiatric Disorders and Involvement of Neurogenesis in the Etiology. Chapter 3 in "Neurogenesis: Cell Biology, Regulation and Role in Disease" Edited by Alicia Moreno

    Abe H, Hidaka N, Kawagoe C, Odagiri K, Ikeda T, Nishimori T, Ishida Y( Role: Joint editor)

    Nova Science Pub. Inc.  2015.11 

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    Language:English Book type:Scholarly book

  • 特殊な状況の患者にどう対応するか−高齢の患者

    宇田川充隆,石田康( Role: Joint editor)

    医学書院  2015.5 

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    Language:Japanese Book type:Scholarly book

  • 精神医学からみたうつ病に伴う疼痛へのアプローチ

    石田康,武田龍一郎( Role: Joint author ,  227-231)

    先端医学社(東京)  2014.7 

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    Language:Japanese Book type:Scholarly book

  • 身体表現性障害

    石田康,武田龍一郎( Role: Joint author)

    日本医師会(東京)  2013.10 

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    Language:Japanese Book type:Scholarly book

  • 宮崎災害精神医学研究会平成23年度活動報告書

    安部博史,石田康ほか( Role: Joint editor)

    宮崎災害精神医学研究会  2012.3 

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    Language:Japanese

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MISC 【 display / non-display

  • 高まる精神科医療へのニーズ Invited

    石田康

    読売新聞   2020

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

  • 「認知症」って何!? 2020新春みやざきの医療 Invited

    石田康

    朝日新聞(宮崎版)   2020

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  • Long-Term Effectiveness of Cognitive Therapy for Refractory Social Anxiety Disorder: One-Year Follow-Up of a Randomized Controlled Trial

    Yoshinaga N., Kubota K., Yoshimura K., Takanashi R., Ishida Y., Iyo M., Fukuda T., Shimizu E.

    Psychotherapy and Psychosomatics   88 ( 4 )   245 - 246   2019.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:Psychotherapy and Psychosomatics  

    DOI: 10.1159/000500108

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  • Corrigendum to “A survey of the effects of ramelteon on benzodiazepine-dependence: Comparison between a ramelteon add-on group and a continuous benzodiazepine administration group” [Asian J. Psychiatry 36 (2018) 20–24](S1876201818300017)(10.1016/j.ajp.2018.05.016)

    Naono-Nagatomo K., Abe H., Araki R., Funahashi H., Takeda R., Taniguchi H., Ishida Y.

    Asian Journal of Psychiatry   40   18   2019.2

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:Asian Journal of Psychiatry  

    © 2019 Elsevier B.V. The authors regret that the following errors were present in the article. In “Abstract” Line 7–11 on Page 20, the sentences “A significant improvement in scores at Week 16 over those of Week 0 was observed in the ramelteon group when a questionnaire concerning BZ-dependence and withdrawal symptoms was used. A significant improvement in scores at Week 16 from those at Week 0 was also observed in the Pittsburgh Sleep Quality Index excerpt and in the Global Assessment of Functioning in the ramelteon group.” were incorrect. The correct sentences are “No significant difference was observed between the ramelteon group and the control group when a questionnaire concerning BZ-dependence and withdrawal symptoms was used. A significant improvement in scores at Week 16 from those at Week 0 was observed in the Pittsburgh Sleep Quality Index excerpt and in the Global Assessment of Functioning in the ramelteon group.” In the values (data) in Table 6, the data for “Questionnaire form (2)” and “PSQI-J (excerpt)” and “GAF” on Page 23, were wrong. (Incorrect) [Table presented] (Correct version) Please replace Table 6 with the following (revised parts are in bold font): [Table presented] The authors would like to apologise for any inconvenience caused by these errors.

    DOI: 10.1016/j.ajp.2019.01.002

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  • 高まる精神科医療へのニーズ.超高齢化社会と向き合う老年精神医学 Invited

    石田康

    読売新聞   2019

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

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Presentations 【 display / non-display

  • 認知症と睡眠 Invited

    石田康

    宮崎地域医療講演会〜認知症と睡眠障害〜 

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    Event date: 2109.3.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • 医療福祉分野における対人援助職の離職と自己効力感について

    永澤美樹,松尾寿栄,三好良英,日髙弘登,石田康

    第72回九州精神神経学会・第65回九州精神医療学会 

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    Event date: 2019.12.12 - 2019.12.13

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 宮崎大学医学部附属病院精神科で修正型電気けいれん療法を施行した統合失調症症例群

    金丸杏奈,治田彩香,蛯原功介,石田康

    第72回九州精神神経学会・第65回九州精神医療学会 

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    Event date: 2019.12.12 - 2019.12.13

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 高ナトリウム血症を呈した多飲水の統合失調症の症例

    吉村清太,鮫島哲郎,三好良英,石田康

    第72回九州精神神経学会・第65回九州精神医療学会 

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    Event date: 2019.12.12 - 2019.12.13

    Language:Japanese   Presentation type:Oral presentation (general)  

  • クロザピン使用中に穿孔性虫垂炎を合併した症例

    松尾倫子,並木薫,牧田昌平,緒方祥吾,寺坂壮史,河野次郎,船橋英樹,石田康

    第72回九州精神神経学会・第65回九州精神医療学会 

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    Event date: 2019.12.12 - 2019.12.13

    Language:Japanese   Presentation type:Oral presentation (general)  

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Grant-in-Aid for Scientific Research 【 display / non-display

  • 光遺伝学を用いて解析するレボドパ誘発性不随意運動におけるアストロサイトの機能関与

    2017.04 - 2020.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • 精神神経疾患の個体差を克服する個別化薬物療法に有用な分子標的放射性診断薬の開発

    2013.04

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

    個体差の大きい精神神経疾患に対する薬物療法の治療効果や副作用の有無を予測できる診断指標を明らかにすることは、薬物療法の個別化・適正化に必須である。本研究では、精神神経疾患薬物療法の最適化を目的として、疾患モデル動物に種々の治療薬を投与し、神経機能に関連する放射性プローブを用いたイメージングにより同一個体における機能変化を評価するとともに、脳内遺伝子発現レベルの変化を解析し、行動薬理・免疫組織化学的評価との比較により、薬効の個体差要因を明らかにする。また、遺伝子解析結果から薬物投与による誘導化が確認されたトランスポータや薬物代謝酵素などの機能性分子の安定発現細胞やベシクルを分子標的プローブのスクリーニング評価に利用する。さらに、治療効果に大きく影響する薬物代謝酵素活性や薬物動態の個体差要因となる機能性分子活性変動を患者個々に解析し、薬物療法の汎用的基盤を与える新規分子標的放射性診断薬の開発を試みる。

  • 脳内ドパミン神経系における転写調節因子の機能解析を目的とした行動薬理学的研究

    2012.04 - 2015.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    脳内ドパミン神経系における転写調節因子の機能解析を目的とした行動薬理学的研究

  • 神経移植とL-DOPA療法がもたらす神経可塑性に関する行動神経薬理学的研究

    2009.04 - 2012.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    神経移植とL-DOPA療法がもたらす神経可塑性に関する行動神経薬理学的研究

  • 脳内神経変性疾患に対する再生医療・遺伝子治療効果判定に有用な放射性診断薬の開発

    2008.04 - 2012.03

    科学研究費補助金  基盤研究(A)

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    Authorship:Coinvestigator(s) 

    脳内神経変性疾患に対する再生医療・遺伝子治療効果判定に有用な放射性診断薬の開発

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