ISHIDA Yasushi

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Clinical Neuroscience, Psychiatry

Title

Professor

External Link

Degree 【 display / non-display

  • 博士(医学) ( 1991.9   宮崎医科大学 )

  • 医学士 ( 1985.3   大分医科大学 )

Research Areas 【 display / non-display

  • Life Science / Psychiatry

  • Life Science / Neuroscience-general

  • Life Science / Neuroscience-general

 

Papers 【 display / non-display

  • Functional MHCI deficiency induces ADHD-like symptoms with increased dopamine D1 receptor expression Reviewed

    Meng H.R., Suenaga T., Edamura M., Fukuda A., Ishida Y., Nakahara D., Murakami G.

    Brain, Behavior, and Immunity   97   22 - 31   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Brain, Behavior, and Immunity  

    Inappropriate synaptic development has been proposed as a potential mechanism of neurodevelopmental disorders, including attention-deficit hyperactivity disorder (ADHD). Major histocompatibility complex class I (MHCI), an immunity-associated molecule expressed by neurons in the brain, regulates synaptic development; however, the involvement of MHCI in these disorders remains elusive. We evaluated whether functional MHCI deficiency induced by β2m−/−Tap1−/− double-knockout in mice leads to abnormalities akin to those seen in neurodevelopmental disorders. We found that functional MHCI deficiency induced locomotor hyperactivity, motor impulsivity, and attention deficits, three major symptoms of ADHD. In contrast, these mice showed normal spatial learning, behavioral flexibility, social behavior, and sensorimotor integration. In the analysis of the dopamine system, upregulation of dopamine D1 receptor (D1R) expression in the nucleus accumbens and a greater locomotor response to D1R agonist SKF 81297 were found in the functional MHCI-deficient mice. Low-dose methylphenidate, used for the treatment of ADHD patients, alleviated the three behavioral symptoms and suppressed c-Fos expression in the D1R-expressing medium spiny neurons of the mice. These findings reveal an unexpected role of MHCI in three major symptoms of ADHD and may provide a novel landmark in the pathogenesis of ADHD

    DOI: 10.1016/j.bbi.2021.05.015

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  • Role of kainate receptors in pruriceptive processing in the mouse spinal cord Reviewed

    Haruta-Tsukamoto A., Kanemaru-Kawazoe A., Kogoh Y., Miyahara Y., Funahashi H., Hirano Y., Nishimori T., Ishida Y.

    European Journal of Pharmacology   957   175998   2023.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:European Journal of Pharmacology  

    Pruritus, including neuropathic and psychogenic pruritus, is an unpleasant feeling that causes a desire to scratch, which negatively impacts physical and psychological aspects of daily life. Nonetheless, little is known about the neural mechanisms involved in pruritus. Glutamate is a predominant excitatory neurotransmitter in the mammalian central nervous system and exerts its effects by binding to various glutamate receptors, including kainate (KA) receptors; however, the precise involvement of each glutamate receptor in pruriceptive processing remains unclear, particularly that of KA receptors. Therefore, the roles of KA receptors in histamine-dependent and -independent itch were investigated using CNQX, an AMPA/KA receptors antagonist, UBP310 and UBP302, antagonists of KA receptors, and small interfering (si)RNAs against KA receptor subunits in mice with acute and chronic pruritus. The effects of KA receptor antagonists on histamine-induced c-Fos expression in the spinal cord were also examined. The intrathecal administration of CNQX reduced the number of scratching events induced by histamine and chloroquine. On the other hand, UBP310 or UBP302 and the siRNAs of KA receptor subunits 1–3 significantly inhibited the induction of scratching events in mice treated with histamine, while no significant change was observed in the induction of spontaneous scratching events in mice with chronic pruritus. In addition, antagonists of KA receptors attenuated c-Fos expression in the superficial layers of the dorsal horn induced by histamine. These results indicate that KA receptors are involved in acute pruriceptive processing in the spinal cord induced by histamine, but not chloroquine or chronic itch.

    DOI: 10.1016/j.ejphar.2023.175998

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  • A case of intractable trigeminal neuralgia improved by a combination of venlafaxine and cognitive behavioral therapy

    Haruta Tomotaka, Ishimoto Akemi, Haruta-Tsukamoto Ayaka, Funahashi Hideki, Ishida Yasushi

    Kyushu Neuropsychiatry   68 ( 2 )   47 - 52   2023.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Association of Kyushu Neuropsychiatry  

    We encountered a case in which a combination of venlafaxine and cognitive behavioral therapy alleviated intractable trigeminal neuralgia. The patient was a 72-year-old woman. Despite treatment for trigeminal neuralgia with various types of medications, nerve blocks, and neurovascular decompression, she reported pain that repeatedly flared up. The patient was transferred to our department and received treatment with a combination of venlafaxine and cognitive behavioral therapy. As a result,the pain was alleviated. Chronic pain tends to be intractable due to physical and psychosocial factors; thus, it is important to combine pharmacotherapy and non-pharmacotherapy to achieve effective treatment. Venlafaxine has no indications for pain in Japan; however, it may be efficacious for treating chronic pain.

    DOI: 10.11642/kyushuneurop.68.2_47

    CiNii Research

  • A case study of the utilization of clozapine treatment for treatment-resistant schizophrenia associated with 22q11.2 deletion syndrome. Reviewed

    Tsurue A, Funahashi H, Tsurue K, Kawano M, Ishida Y, Hirano Y

    Neuropsychopharmacology reports   43 ( 2 )   272 - 276   2023.3

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    Language:English   Publishing type:Case report   Publisher:Neuropsychopharmacology Reports  

    Background: The optimal treatment strategy for patients with treatment-resistant schizophrenia (TRS) associated with 22q11.2 deletion syndrome (DS) remains a subject of debate. Case Presentation: We present the case of a 40-year-old female patient diagnosed with TRS and 22q11.2DS who was effectively treated with clozapine. She was diagnosed with schizophrenia and mild intellectual disability during her adolescence; despite being hospitalized for a period of 10 years beginning in her 30s, she continued to exhibit symptoms of impulsivity, and explosive behavior, requiring periods of isolation. We ultimately decided to switch her medication to clozapine, which was administered with caution and gradually titrated upward, with no discernable adverse effects, resulting in a marked improvement in her symptoms and obviated the need for isolation. Subsequently, the patient's history of congenital heart disease and facial abnormalities prompted initial suspicions of a 22q11.2DS diagnosis, which was subsequently confirmed through genetic testing. Conclusion: Clozapine may serve as an efficacious pharmacological intervention for TRS patients with 22q11.2DS, including those of Asian descent.

    DOI: 10.1002/npr2.12333

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  • Frailty Improvement by Multicomponent Drug, Ninjin'Yoeito, in Mild Cognitive Impairment and Mild Alzheimer's Disease Patients: An Open-Label Exploratory Study (FRAMINGO) Reviewed

    Okahara K., Ohsawa M., Haruta-Tsukamoto A., Miyoshi R., Funahashi H., Fukutani Y., Makita S., Matsuo H., Ishida Y., Numomura A.

    Journal of Alzheimer's Disease Reports   7 ( 1 )   107 - 117   2023.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Alzheimer's Disease Reports  

    Background: Alzheimer's disease (AD) and dementia have increasingly been conceived of as 'complex diseases of aging', determined by multiple, simultaneous, interacting pathophysiological processes. The condition known as frailty is a phenotype of aging and its comprehensive pathophysiology is thought to be closely related to the incidence of mild cognitive impairment (MCI) and the exacerbation of dementia. Objective: This study aimed to investigate the effect of the multicomponent drug, ninjin'yoeito (NYT), on frailty in MCI and mild AD patients. Methods: This study was an open-label trial. A total of 14 patients, including 9 with MCI and 5 with mild AD, were enrolled. Among them, 11 were frail while 3 were prefrail. NYT (6-9 g/day) was administered orally for 24 weeks, and assessments were carried out at baseline (week 0), and at 4, 8, 16, and 24 weeks. Results: In the primary endpoint, significant early improvements were observed in the anorexia scores according to the Neuropsychiatric Inventory after four weeks of treatment with NYT. The Cardiovascular Health Study score was significantly improved, and no frailty was observed after 24 weeks. The fatigue visual analog scale scores also significantly improved. The Clinical Dementia Rating and the Montreal Cognitive Assessment scores remained at baseline levels during the NYT treatment period. Conclusion: The results suggest that NYT may be effective in the treatment of frailty, especially for anorexia and fatigue, in both MCI and mild AD patients, which would be beneficial for the prognosis of dementia.

    DOI: 10.3233/ADR-220074

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Books 【 display / non-display

  • Influence of Prenatal Stress on Psychiatric Disorders and Involvement of Neurogenesis in the Etiology. Chapter 3 in "Neurogenesis: Cell Biology, Regulation and Role in Disease" Edited by Alicia Moreno

    Abe H, Hidaka N, Kawagoe C, Odagiri K, Ikeda T, Nishimori T, Ishida Y( Role: Joint editor)

    Nova Science Pub. Inc.  2015.11 

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    Language:English Book type:Scholarly book

  • 特殊な状況の患者にどう対応するか−高齢の患者

    宇田川充隆,石田康( Role: Joint editor)

    医学書院  2015.5 

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    Language:Japanese Book type:Scholarly book

  • 精神医学からみたうつ病に伴う疼痛へのアプローチ

    石田康,武田龍一郎( Role: Joint author ,  227-231)

    先端医学社(東京)  2014.7 

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    Language:Japanese Book type:Scholarly book

  • 身体表現性障害

    石田康,武田龍一郎( Role: Joint author)

    日本医師会(東京)  2013.10 

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    Language:Japanese Book type:Scholarly book

  • 宮崎災害精神医学研究会平成23年度活動報告書

    安部博史,石田康ほか( Role: Joint editor)

    宮崎災害精神医学研究会  2012.3 

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    Language:Japanese

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MISC 【 display / non-display

  • 高まる精神科医療へのニーズ Invited

    石田康

    読売新聞   2020

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

  • 「認知症」って何!? 2020新春みやざきの医療 Invited

    石田康

    朝日新聞(宮崎版)   2020

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  • Long-Term Effectiveness of Cognitive Therapy for Refractory Social Anxiety Disorder: One-Year Follow-Up of a Randomized Controlled Trial

    Yoshinaga N., Kubota K., Yoshimura K., Takanashi R., Ishida Y., Iyo M., Fukuda T., Shimizu E.

    Psychotherapy and Psychosomatics   88 ( 4 )   245 - 246   2019.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:Psychotherapy and Psychosomatics  

    DOI: 10.1159/000500108

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  • Corrigendum to “A survey of the effects of ramelteon on benzodiazepine-dependence: Comparison between a ramelteon add-on group and a continuous benzodiazepine administration group” [Asian J. Psychiatry 36 (2018) 20–24](S1876201818300017)(10.1016/j.ajp.2018.05.016)

    Naono-Nagatomo K., Abe H., Araki R., Funahashi H., Takeda R., Taniguchi H., Ishida Y.

    Asian Journal of Psychiatry   40   18   2019.2

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:Asian Journal of Psychiatry  

    © 2019 Elsevier B.V. The authors regret that the following errors were present in the article. In “Abstract” Line 7–11 on Page 20, the sentences “A significant improvement in scores at Week 16 over those of Week 0 was observed in the ramelteon group when a questionnaire concerning BZ-dependence and withdrawal symptoms was used. A significant improvement in scores at Week 16 from those at Week 0 was also observed in the Pittsburgh Sleep Quality Index excerpt and in the Global Assessment of Functioning in the ramelteon group.” were incorrect. The correct sentences are “No significant difference was observed between the ramelteon group and the control group when a questionnaire concerning BZ-dependence and withdrawal symptoms was used. A significant improvement in scores at Week 16 from those at Week 0 was observed in the Pittsburgh Sleep Quality Index excerpt and in the Global Assessment of Functioning in the ramelteon group.” In the values (data) in Table 6, the data for “Questionnaire form (2)” and “PSQI-J (excerpt)” and “GAF” on Page 23, were wrong. (Incorrect) [Table presented] (Correct version) Please replace Table 6 with the following (revised parts are in bold font): [Table presented] The authors would like to apologise for any inconvenience caused by these errors.

    DOI: 10.1016/j.ajp.2019.01.002

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  • せん妄による自殺企図 Invited

    三好良英,石田康

    九州神経精神医学   65 ( 2 )   86 - 88   2019

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations 【 display / non-display

  • 認知症と睡眠 Invited

    石田康

    宮崎地域医療講演会〜認知症と睡眠障害〜 

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    Event date: 2109.3.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • 医療福祉分野における対人援助職の離職と自己効力感について

    永澤美樹,松尾寿栄,三好良英,日髙弘登,石田康

    第72回九州精神神経学会・第65回九州精神医療学会 

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    Event date: 2019.12.12 - 2019.12.13

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 宮崎大学医学部附属病院精神科で修正型電気けいれん療法を施行した統合失調症症例群

    金丸杏奈,治田彩香,蛯原功介,石田康

    第72回九州精神神経学会・第65回九州精神医療学会 

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    Event date: 2019.12.12 - 2019.12.13

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 高ナトリウム血症を呈した多飲水の統合失調症の症例

    吉村清太,鮫島哲郎,三好良英,石田康

    第72回九州精神神経学会・第65回九州精神医療学会 

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    Event date: 2019.12.12 - 2019.12.13

    Language:Japanese   Presentation type:Oral presentation (general)  

  • クロザピン使用中に穿孔性虫垂炎を合併した症例

    松尾倫子,並木薫,牧田昌平,緒方祥吾,寺坂壮史,河野次郎,船橋英樹,石田康

    第72回九州精神神経学会・第65回九州精神医療学会 

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    Event date: 2019.12.12 - 2019.12.13

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Grant-in-Aid for Scientific Research 【 display / non-display

  • パーキンソン病モデルラットのアロディニアに関連した線条体アストロサイトの機能解析

    Grant number:21K07503  2021.04 - 2024.03

    独立行政法人日本学術振興会  科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • 光遺伝学を用いて解析するレボドパ誘発性不随意運動におけるアストロサイトの機能関与

    Grant number:17K10277  2017.04 - 2022.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • 精神神経疾患の個体差を克服する個別化薬物療法に有用な分子標的放射性診断薬の開発

    2013.04

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

    個体差の大きい精神神経疾患に対する薬物療法の治療効果や副作用の有無を予測できる診断指標を明らかにすることは、薬物療法の個別化・適正化に必須である。本研究では、精神神経疾患薬物療法の最適化を目的として、疾患モデル動物に種々の治療薬を投与し、神経機能に関連する放射性プローブを用いたイメージングにより同一個体における機能変化を評価するとともに、脳内遺伝子発現レベルの変化を解析し、行動薬理・免疫組織化学的評価との比較により、薬効の個体差要因を明らかにする。また、遺伝子解析結果から薬物投与による誘導化が確認されたトランスポータや薬物代謝酵素などの機能性分子の安定発現細胞やベシクルを分子標的プローブのスクリーニング評価に利用する。さらに、治療効果に大きく影響する薬物代謝酵素活性や薬物動態の個体差要因となる機能性分子活性変動を患者個々に解析し、薬物療法の汎用的基盤を与える新規分子標的放射性診断薬の開発を試みる。

  • 脳内ドパミン神経系における転写調節因子の機能解析を目的とした行動薬理学的研究

    2012.04 - 2015.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    脳内ドパミン神経系における転写調節因子の機能解析を目的とした行動薬理学的研究

  • 神経移植とL-DOPA療法がもたらす神経可塑性に関する行動神経薬理学的研究

    2009.04 - 2012.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    神経移植とL-DOPA療法がもたらす神経可塑性に関する行動神経薬理学的研究

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