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Affiliation |
Faculty of Medicine School of Medicine Department of Clinical Neuroscience, Psychiatry |
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Professor |
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External Link |
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ISHIDA Yasushi
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Degree 【 display / non-display 】
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博士（医学） ( 1991.9 宮崎医科大学 )
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医学士 ( 1985.3 大分医科大学 )
Research Areas 【 display / non-display 】
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Life Science / Psychiatry
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Life Science / Neuroscience-general
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Life Science / Neuroscience-general
Papers 【 display / non-display 】
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Functional MHCI deficiency induces ADHD-like symptoms with increased dopamine D1 receptor expression Reviewed
Meng H.R., Suenaga T., Edamura M., Fukuda A., Ishida Y., Nakahara D., Murakami G.
Brain, Behavior, and Immunity 97 22 - 31 2021.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Brain, Behavior, and Immunity
Inappropriate synaptic development has been proposed as a potential mechanism of neurodevelopmental disorders, including attention-deficit hyperactivity disorder (ADHD). Major histocompatibility complex class I (MHCI), an immunity-associated molecule expressed by neurons in the brain, regulates synaptic development; however, the involvement of MHCI in these disorders remains elusive. We evaluated whether functional MHCI deficiency induced by β2m−/−Tap1−/− double-knockout in mice leads to abnormalities akin to those seen in neurodevelopmental disorders. We found that functional MHCI deficiency induced locomotor hyperactivity, motor impulsivity, and attention deficits, three major symptoms of ADHD. In contrast, these mice showed normal spatial learning, behavioral flexibility, social behavior, and sensorimotor integration. In the analysis of the dopamine system, upregulation of dopamine D1 receptor (D1R) expression in the nucleus accumbens and a greater locomotor response to D1R agonist SKF 81297 were found in the functional MHCI-deficient mice. Low-dose methylphenidate, used for the treatment of ADHD patients, alleviated the three behavioral symptoms and suppressed c-Fos expression in the D1R-expressing medium spiny neurons of the mice. These findings reveal an unexpected role of MHCI in three major symptoms of ADHD and may provide a novel landmark in the pathogenesis of ADHD
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A case study of the utilization of clozapine treatment for treatment-resistant schizophrenia associated with 22q11.2 deletion syndrome. Reviewed
Tsurue A, Funahashi H, Tsurue K, Kawano M, Ishida Y, Hirano Y
Neuropsychopharmacology reports 2023.3
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Okahara K., Ohsawa M., Haruta-Tsukamoto A., Miyoshi R., Funahashi H., Fukutani Y., Makita S., Matsuo H., Ishida Y., Numomura A.
Journal of Alzheimer's Disease Reports 7 ( 1 ) 107 - 117 2023.2
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Alzheimer's Disease Reports
Background: Alzheimer's disease (AD) and dementia have increasingly been conceived of as 'complex diseases of aging', determined by multiple, simultaneous, interacting pathophysiological processes. The condition known as frailty is a phenotype of aging and its comprehensive pathophysiology is thought to be closely related to the incidence of mild cognitive impairment (MCI) and the exacerbation of dementia. Objective: This study aimed to investigate the effect of the multicomponent drug, ninjin'yoeito (NYT), on frailty in MCI and mild AD patients. Methods: This study was an open-label trial. A total of 14 patients, including 9 with MCI and 5 with mild AD, were enrolled. Among them, 11 were frail while 3 were prefrail. NYT (6-9 g/day) was administered orally for 24 weeks, and assessments were carried out at baseline (week 0), and at 4, 8, 16, and 24 weeks. Results: In the primary endpoint, significant early improvements were observed in the anorexia scores according to the Neuropsychiatric Inventory after four weeks of treatment with NYT. The Cardiovascular Health Study score was significantly improved, and no frailty was observed after 24 weeks. The fatigue visual analog scale scores also significantly improved. The Clinical Dementia Rating and the Montreal Cognitive Assessment scores remained at baseline levels during the NYT treatment period. Conclusion: The results suggest that NYT may be effective in the treatment of frailty, especially for anorexia and fatigue, in both MCI and mild AD patients, which would be beneficial for the prognosis of dementia.
DOI： 10.3233/ADR-220074
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Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study. Reviewed
Yasuda K, Takeda R, Ikeda, Ishida Y
Psychiatry Clin Neurosci Rep 2 2023
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1002/pcn5.76
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Measurement of Hepatic CYP3A4 and 2D6 Activity Using Radioiodine-Labeled <i>O</i>-Desmethylvenlafaxine. Reviewed
Mizutani A, Kobayashi M, Aibe R, Muranaka Y, Nishi K, Kitamura M, Suzuki C, Nishii R, Shikano N, Magata Y, Ishida Y, Kunishima M, Kawai K
International journal of molecular sciences 23 ( 19 ) 2022.9
Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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Influence of Prenatal Stress on Psychiatric Disorders and Involvement of Neurogenesis in the Etiology. Chapter 3 in "Neurogenesis: Cell Biology, Regulation and Role in Disease" Edited by Alicia Moreno
Abe H, Hidaka N, Kawagoe C, Odagiri K, Ikeda T, Nishimori T, Ishida Y（ Role： Joint editor）
Nova Science Pub. Inc. 2015.11
Language：English Book type：Scholarly book
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特殊な状況の患者にどう対応するか−高齢の患者
宇田川充隆，石田康（ Role： Joint editor）
医学書院 2015.5
Language：Japanese Book type：Scholarly book
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精神医学からみたうつ病に伴う疼痛へのアプローチ
石田康，武田龍一郎（ Role： Joint author , 227-231）
先端医学社（東京） 2014.7
Language：Japanese Book type：Scholarly book
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身体表現性障害
石田康，武田龍一郎（ Role： Joint author）
日本医師会（東京） 2013.10
Language：Japanese Book type：Scholarly book
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宮崎災害精神医学研究会平成23年度活動報告書
安部博史，石田康ほか（ Role： Joint editor）
宮崎災害精神医学研究会 2012.3
Language：Japanese
MISC 【 display / non-display 】
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高まる精神科医療へのニーズ Invited
石田康
読売新聞 2020
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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「認知症」って何！？ 2020新春みやざきの医療 Invited
石田康
朝日新聞(宮崎版） 2020
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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Yoshinaga N., Kubota K., Yoshimura K., Takanashi R., Ishida Y., Iyo M., Fukuda T., Shimizu E.
Psychotherapy and Psychosomatics 88 ( 4 ) 245 - 246 2019.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Psychotherapy and Psychosomatics
DOI： 10.1159/000500108
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Naono-Nagatomo K., Abe H., Araki R., Funahashi H., Takeda R., Taniguchi H., Ishida Y.
Asian Journal of Psychiatry 40 18 2019.2
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Asian Journal of Psychiatry
© 2019 Elsevier B.V. The authors regret that the following errors were present in the article. In “Abstract” Line 7–11 on Page 20, the sentences “A significant improvement in scores at Week 16 over those of Week 0 was observed in the ramelteon group when a questionnaire concerning BZ-dependence and withdrawal symptoms was used. A significant improvement in scores at Week 16 from those at Week 0 was also observed in the Pittsburgh Sleep Quality Index excerpt and in the Global Assessment of Functioning in the ramelteon group.” were incorrect. The correct sentences are “No significant difference was observed between the ramelteon group and the control group when a questionnaire concerning BZ-dependence and withdrawal symptoms was used. A significant improvement in scores at Week 16 from those at Week 0 was observed in the Pittsburgh Sleep Quality Index excerpt and in the Global Assessment of Functioning in the ramelteon group.” In the values (data) in Table 6, the data for “Questionnaire form (2)” and “PSQI-J (excerpt)” and “GAF” on Page 23, were wrong. (Incorrect) [Table presented] (Correct version) Please replace Table 6 with the following (revised parts are in bold font): [Table presented] The authors would like to apologise for any inconvenience caused by these errors.
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慢性疼痛とうつ Invited
石田康
DEPRESSION JOURNAL 7 ( 3 ) 84 - 85 2019
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
Presentations 【 display / non-display 】
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認知症と睡眠 Invited
石田康
宮崎地域医療講演会〜認知症と睡眠障害〜
Event date： 2109.3.1
Language：Japanese Presentation type：Oral presentation (invited, special)
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医療福祉分野における対人援助職の離職と自己効力感について
永澤美樹，松尾寿栄，三好良英，日髙弘登，石田康
第72回九州精神神経学会・第65回九州精神医療学会
Event date： 2019.12.12 - 2019.12.13
Language：Japanese Presentation type：Oral presentation (general)
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宮崎大学医学部附属病院精神科で修正型電気けいれん療法を施行した統合失調症症例群
金丸杏奈，治田彩香，蛯原功介，石田康
第72回九州精神神経学会・第65回九州精神医療学会
Event date： 2019.12.12 - 2019.12.13
Language：Japanese Presentation type：Oral presentation (general)
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高ナトリウム血症を呈した多飲水の統合失調症の症例
吉村清太，鮫島哲郎，三好良英，石田康
第72回九州精神神経学会・第65回九州精神医療学会
Event date： 2019.12.12 - 2019.12.13
Language：Japanese Presentation type：Oral presentation (general)
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クロザピン使用中に穿孔性虫垂炎を合併した症例
松尾倫子，並木薫，牧田昌平，緒方祥吾，寺坂壮史，河野次郎，船橋英樹，石田康
第72回九州精神神経学会・第65回九州精神医療学会
Event date： 2019.12.12 - 2019.12.13
Language：Japanese Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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パーキンソン病モデルラットのアロディニアに関連した線条体アストロサイトの機能解析
Grant number：21K07503 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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光遺伝学を用いて解析するレボドパ誘発性不随意運動におけるアストロサイトの機能関与
Grant number：17K10277 2017.04 - 2022.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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精神神経疾患の個体差を克服する個別化薬物療法に有用な分子標的放射性診断薬の開発
2013.04
科学研究費補助金 基盤研究(B)
Authorship：Coinvestigator(s)
個体差の大きい精神神経疾患に対する薬物療法の治療効果や副作用の有無を予測できる診断指標を明らかにすることは、薬物療法の個別化・適正化に必須である。本研究では、精神神経疾患薬物療法の最適化を目的として、疾患モデル動物に種々の治療薬を投与し、神経機能に関連する放射性プローブを用いたイメージングにより同一個体における機能変化を評価するとともに、脳内遺伝子発現レベルの変化を解析し、行動薬理・免疫組織化学的評価との比較により、薬効の個体差要因を明らかにする。また、遺伝子解析結果から薬物投与による誘導化が確認されたトランスポータや薬物代謝酵素などの機能性分子の安定発現細胞やベシクルを分子標的プローブのスクリーニング評価に利用する。さらに、治療効果に大きく影響する薬物代謝酵素活性や薬物動態の個体差要因となる機能性分子活性変動を患者個々に解析し、薬物療法の汎用的基盤を与える新規分子標的放射性診断薬の開発を試みる。
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脳内ドパミン神経系における転写調節因子の機能解析を目的とした行動薬理学的研究
2012.04 - 2015.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
脳内ドパミン神経系における転写調節因子の機能解析を目的とした行動薬理学的研究
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神経移植とＬ－ＤＯＰＡ療法がもたらす神経可塑性に関する行動神経薬理学的研究
2009.04 - 2012.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
神経移植とＬ－ＤＯＰＡ療法がもたらす神経可塑性に関する行動神経薬理学的研究