Papers - IKEDA Masahiro
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Aquaporin 3 is expressed in the basaloid cells of canine sebaceous glands Reviewed
Sonoda, H., Taniguchi, Y., Fujimoto, N., Higashijima, Y., Matsuzaki, T., Hirai, T., Itoh, T., Uchida, K., Ikeda, M..
Journal of Veterinary Medical Science 86 ( 10 ) 1063 - 1067 2024.10
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Glucocorticoid-induced acute diuresis in rats in relation to the reduced renal expression of sodium-dependent cotransporter genes Reviewed
Zhao, P., Higashijima, Y., Sonoda, H., Morinaga, R., Uema, K., Oguchi, A., Matsuzaki, T., Ikeda, M.
Journal of Pharmacological Science 156 ( 2 ) 115 - 124 2024.10
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Expression patterns of aquaporins 1, 3, 5 in canine mammary gland carcinomas Reviewed
Fujimoto N., Taniguchi Y., Sonoda H., Kaneko Y., Matsuzaki T., Itoh T., Hirai T., Uchida K., Ikeda M.
Journal of Veterinary Medical Science 86 ( 2 ) 168 - 179 2024.2
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1292/jvms.23-0278
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Blueberry Stem Extract Prevents Lacrimal Hyposecretion in Non-obese Diabetic Mice via Activation of AMPK Reviewed
Ogawa, K., Ohno, Y., Tagashira, A., Urata, K., Satoh, K., Fujimoto, N., Sonoda, H., Ikeda, M., Matsuzaki, T., Nishiyama, K., Kunitake, H., Goto, Y., Yamasaki, M.
In Vivo 2023.4
Language：English Publishing type：Research paper (scientific journal)
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Upregulation of NADPH oxidase 2 contributes to renal fibrosis in pcy mice: an experimental model of nephronophthisis Reviewed
Hoshino, Y., Sonoda, H., Mikoda, N., Ikeda, M.
Nephron 146 ( 4 ) 393 - 403 2022.7
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1159/000520697
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Rhabdomyolysis, myoglobinuric nephrosis, and crystalline nephropathy in a captive bottlenose dolphin Reviewed
Nueangphuet, P., Hamano, T., Hirai, T., Sakaguchi, Y., Sonoda, H., Otsuka, M., Osamu, Y., Hobo, S., Ikeda, M., Yamaguchi, R.
J. Vet. Diagn. Invest. 34 ( 4 ) 668 - 673 2022.7
Language：English Publishing type：Research paper (scientific journal)
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Reduced urinary release of AQP1- and AQP2-bearing extracellular vesicles in patients with advanced chronic kidney disease Reviewed
Oshikawa-Hori, S., Yokota-Ikeda, N., Sonoda, H., Sasaki, Y., Ikeda, M.
Physiological Reports 9 ( 17 ) e15005 2021.9
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.14814/phy2.15005
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Onion ( Allium cepa L.)-derived nanoparticles inhibited LPS-Induced nitrate production, however, their intracellular incorporation by endocytosis was not involved in this effect on RAW264 cells Reviewed
Yamasaki, M., Yamasaki, Y., Furusho, R., Kimura, H., Kamei, I., Sonoda, H., Ikeda, M., Oshima, T., Ogawa, K., Nishiyama, K.
Molecules 26 ( 9 ) 2763 - 2763 2021.5
Language：English Publishing type：Research paper (scientific journal)
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Urinary exosomes as a possible source of kidney disease biomarkers Invited
Abdeen, A., Sonoda, H., Tanaka, A., Ikeda, M.
Role of Exosomes in Biological Communication Systems 221 - 244 2020.11
Language：English Publishing type：Research paper (scientific journal)
DOI： org/10.1007/978-981-15-6599-1_10
Other Link： https://doi.org/10.1007/978-981-15-6599-1_10
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Decreased excretion of urinary exosomal aquaporin-2 in a puromycin aminonucleoside-induced nephrotic syndrome model Reviewed
Abdeen, A., Sonoda, H., Kaito, A., Oshikawa-Hori, S., Fujimoto, N., Ikeda, M.
Int. J. Mol. Sci. 21 ( 12 ) E4288 - E4288 2020.6
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3390/ijms21124288
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Release of urinary aquaporin-2-bearing extracellular vesicles is decreased in pregnant Japanese Black cattle Reviewed
Sinlapadeelerdkul T., Sonoda H., Uchida K., Kitahara G., Ikeda M.
Journal of Veterinary Medical Science 81 ( 11 ) 1609 - 1615 2019.11
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1292/jvms.19-0276
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Urinary extracellular vesicular release of aquaporins in patients with renal transplantation Reviewed
Oshikawa-Hori S., Yokota-Ikeda N., Sonoda H., Ikeda M.
BMC Nephrology 20 ( 1 ) 216 2019.6
Language：English Publishing type：Research paper (scientific journal)
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健常犬における水素ガス吸入の安全性および吸入麻酔時の酸化ストレス抑制効果についての検討 Reviewed
山本集士，鳥巣至道，網谷龍太，黒川亮介，平野伸一，Benedict Huai Ern ONG，園田紘子，金子泰之，水谷真也，池田正浩，永延清和
比較統合医療学会誌 26 ( 2 ) 5 - 12 2019.6
Language：Japanese Publishing type：Research paper (scientific journal)
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A bell-shaped pattern of urinary aquaporin-2-bearing extracellular vesicle release in an experimental model of nephronophthisis Reviewed
Mikoda N., Sonoda H., Oshikawa S., Hoshino Y., Matsuzaki T., Ikeda M.
Physiological Reports 7 ( 9 ) pii: E139 2019.5
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.14814/phy2.14092
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miRNA profiling of urinary exosomes to assess the progression of acute kidney injury Reviewed
Sonoda H., Lee B., Park K., Nihalani D., Yoon J., Ikeda M., Kwon S.
Scientific Reports 9 ( 1 ) 4692 2019.3
Language：English Publishing type：Research paper (scientific journal)
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An early decrease in release of aquaporin-2 in urinary extracellular vesicles after cisplatin treatment in rats Reviewed
Sonoda H, Oshikawa-Hori S, Ikeda M
Cells 8 ( 2 ) pii: E139 2019.2
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3390/cells8020139
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Involvement of the NADPH oxidase 2 pathway in renal oxidative stress in Aqp11 <sup>-/-</sup> mice Reviewed
Hoshino Y., Sonoda H., Nishimura R., Mori K., Ishibashi K., Ikeda M.
Biochemistry and Biophysics Reports 17 169 - 176 2019.1
Language：English Publishing type：Research paper (scientific journal)
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Characterization of urinary exosomal release of aquaporin-1 and -2 after renal ischemia-reperfusion in rats Reviewed
Asvapromtada S., Sonoda H., Kinouchi M., Oshikawa S., Takahashi S., Hoshino Y., Sinlapadeelerdkul T., Yokota-Ikeda N., Matsuzaki T., Ikeda M.
American Journal of Physiology - Renal Physiology 314 ( 4 ) F584 - F601 2018.4
Language：English Publishing type：Research paper (scientific journal)
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Acetazolamide enhances the release of urinary exosomal aquaporin-1 Reviewed
Abdeen A., Abdeen A., Sonoda H., Oshikawa S., Hoshino Y., Kondo H., Ikeda M.
Nephrology Dialysis Transplantation 31 ( 10 ) 1623 - 1632 2016.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Nephrology Dialysis Transplantation
© 2016 The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.BackgroundRenal aquaporin-1 (AQP1), a water channel protein, is known to be secreted into urine, conveyed by nano-sized extracellular vesicles called exosomes. A previous study has demonstrated that acetazolamide (AZ), a diuretic that inhibits carbonic anhydrases, alters the expression level of AQP1 in cultured cells. Here we investigated whether AZ alters the release of urinary exosomal AQP1 in vivo. MethodsThe effect of AZ on urinary exosomal AQP1 secretion was examined in rats and compared with furosemide (another diuretic), NaHCO3 (an alkalizing agent) and NH4Cl (an acidifying agent). Urine, blood and kidney samples were obtained 2 h after each treatment. Urinary exosomes were isolated by a differential centrifugation technique and urinary exosomal proteins were analyzed by immunoblotting. ResultsThe release of exosomal AQP1 into urine was markedly increased after treatment with AZ, accompanied by alkaluria and metabolic acidosis. Immunohistochemistry clearly demonstrated that AZ increased the apical membrane expression of AQP1 in the proximal tubules. AZ did not affect the release of exosomal marker proteins (tumor susceptibility gene 101 protein and apoptosis-linked gene 2 interacting protein X). Treatment with furosemide did not change, whereas NaHCO3 and NH4Cl decreased the exosomal release of AQP1. ConclusionThe present findings indicate that AZ increases the release of exosomal AQP1 into urine in association with enhanced apical membrane expression of AQP1.
DOI： 10.1093/ndt/gfw033
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Aquaporins in urinary extracellular vesicles (exosomes) Reviewed
Oshikawa, S., Sonoda, H., Ikeda, M.
Int. J. Mol. Sci. 17 ( 6 ) pii: E957 2016.6
Language：English Publishing type：Research paper (scientific journal)
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Arterial blood gas anomaly in canine hepatobiliary disease Reviewed
Kaneko, Y., Torisu, S., Kobayashi, T., Mizutani, S., Tsuzuki, N., Sonoda, H., Ikeda, M., Naganobu, K.
J. Vet. Med. Sci. 77 ( 12 ) 1633 - 1638 2016.1
Language：English Publishing type：Research paper (scientific journal)
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Regulation of aquaporins by vasopressin in the kidney Invited
Ikeda, M., Matsuzaki, T.
Vitam. Horm. 98 307 - 337 2015.2
Language：English Publishing type：Research paper (scientific journal)
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Urinary excretion pattern of exosomal aquaporin-2 in rats receiving gentamicin Reviewed
Abdeen, A., Sonoda, H., El-Shawarby, R., Takahashi, S., Ikeda, M.
Am. J. Physiol. Renal Physiol. 307 ( 11 ) F1227 - F1237 2014.12
Language：English Publishing type：Research paper (scientific journal)
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The role of cysteine 227 in subcellular localization, water permeability, and multimerization of aquaporin-11 Reviewed
Takahashi, S., Muta, K., Sonoda, H., Kato, A., Abdeen, A., Ikeda, M.
FEBS Open Bio 4 315 - 320 2014.3
Language：English Publishing type：Research paper (scientific journal)
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Alpha Lipoic Acid supressed migration and invasion via downregulation of cell surface β1-integrin expression in badder cancer cells Reviewed
Yamasaki, M., Iwase, M., Kawano, K., Sakakibara, Y., Suiko, M., Ikeda, M., Nishiyama, K.
J. Clin. Biochem. Nutr. 54 ( 1 ) 18 - 25 2014.1
Language：English Publishing type：Research paper (scientific journal)
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Excretion of urinary exosomal AQP2 in rats is regulated by vasopressin and urinary pH Reviewed
Higashijima, Y., Sonoda, H., Takahashi, S., Kondo, H., Shigemura, K., Ikeda, M.
Am. J. Physiol. Renal Physiol. 304 ( 10 ) F1295 - F1307 2013.11
Language：English Publishing type：Research paper (scientific journal)
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A new method for rapid detection of the mutant allele for Chediak-Higashi syndrome in Japanese Black cattle Reviewed
Abdeen, A., Sonoda, H., Kobayashi, I., Kitahara, G., Ikeda, M.
J. Vet. Med. Sci. 2013.9
Language：English Publishing type：Research paper (scientific journal)
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Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress Reviewed
Atochina-Vasserman, E.N., Biktasova, A., Abramova, E., Cheng, D.S., Polosukhin, V.V., Tanjore, H., Takahashi, S., Sonoda, H., Foye, L., Venkov, C., Ryzhov, S.V., Novitskiy, S., Shlonimskaya, N., Ikeda, M., Blackwell, T.S., Lawson, W.E., Gow, A.J., Harris, R.C., Dikov, M.M., Tchekneva, E.E.
Am J. Physiol. Renal Physiol 304 ( 10 ) F1295 - F1307 2013.5
Language：English Publishing type：Research paper (scientific journal)
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Spironolactone, but not eplerenone, impairs glucose tolerance in a rat model of metabolic syndrome Reviewed
Homma, T., Fujisawa, M., Arai, K., Ishii, M., Sada, T., Ikeda, M.
J. Vet. Med. Sci. 74 ( 8 ) 1015 - 1022 2012.8
Language：English Publishing type：Research paper (scientific journal)
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Homma T., Homma T., Sonoda H., Manabe K., Arai K., Mizuno M., Sada T., Ikeda M.
American Journal of Physiology - Renal Physiology 302 ( 6 ) F750 - 61 2012.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：American Journal of Physiology - Renal Physiology
Although chronic cardiac dysfunction is known to progressively exacerbate renal injury, a condition known as type 2 cardiorenal syndrome (CRS), the mechanism responsible is largely unknown. The present study was undertaken to clarify the mechanism of renal injury in rats with both unilateral nephrectomy (NX) and surgically induced myocardial infarction (MI), corresponding to a model of type 2 CRS. Compared with a control group, rats with both MI and NX (MI+NX) exhibited progressive proteinuria during the experimental period (34 wk after MI surgery), whereas proteinuria was not observed in rats with MI alone and was moderate in rats with NX alone. The proteinuria in rats with MI+NX was associated with renal lesions such as glomerulosclerosis and infiltration of mononuclear cells and upregulation of the renal proinflammatory and -fibrotic cytokine and angiotensin II type 1a receptor (AT1aR) genes. In contrast, plasma renin activity was lowered in rats with MI+NX. Immunohistochemistry revealed that the increased AT1R protein was present mainly in renal interstitial mononuclear cells. Olmesartan medoxomil, an AT1R blocker, markedly reduced the proteinuria and infiltration of mononuclear cells, whereas spironolactone, a mineralocorticoid receptor blocker, did not. The present findings demonstrate the pathogenetic role of renal interstitial AT1R signaling in a model of type 2 CRS, providing evidence that AT1R blockade can be a useful therapeutic option for this syndrome. © 2012 the American Physiological Society.
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The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function Reviewed
Ikeda, M., Andoo, A., Shimono, M., Takamatsu, N., Taki, A., Muta, K., Matsushita, W., Uechi, T., Matsuzaki, T., Kenmochi, N., Takata, K., Sasaki, S., Ito, K., Ishibashi, K.
J. Biol. Chem. 286 ( 5 ) 3342 - 3350 2011.2
Language：English Publishing type：Research paper (scientific journal)
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The protective effect of radicicol against renal ischemia-reperfusion injury in mice Reviewed
Sonoda, H., Prachasilchai, W., Kondo, H., Yokota-Ikeda, N., Oshikawa, S., Ito, K., Ikeda, M.
J. Pharmacol. Sci. 112 ( 2 ) 242 - 246 2010.2
Language：English Publishing type：Research paper (scientific journal)
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Decreased abundance of urinary exosomal aquaporin-1 in renal ischemia reperfusion injury Reviewed
Sonoda, H., Yokota-Ikeda, N., Oshikawa, S., Kanno, Y., Yoshinaga, K., Uchida, K., Ueda, Y., Kimiya, K., Uezono, S., Ueda, A., Ito, K., Ikeda, M.
Am. J. Physiol. Renal Physiol. 297 ( 4 ) F1006 - F1016 2009.10
Language：English Publishing type：Research paper (scientific journal)
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Amelioration of renal ischemia-reperfusion injury by inhibition of IL-6 production in the poloxamer 407-induced mouse model of hyperlipidemia Reviewed
Sharyo, S., Kumagai, K, Yokota-Ikeda, N., Ito, K., Ikeda, M.
J. Pharmacol. Sci. 110 ( 1 ) 47 - 54 2009.5
Language：English Publishing type：Research paper (scientific journal)
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A protective role of unfolded protein response in mouse ischemic acute kidney injury
Prachasilchai W., Sonoda H., Yokota-Ikeda N., Oshikawa S., Aikawa C., Uchida K., Ito K., Kudo T., Imaizumi K., Ikeda M.
European Journal of Pharmacology 592 ( 1-3 ) 138 - 145 2008.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：European Journal of Pharmacology
Although renal ischemia-reperfusion is known to activate the unfolded protein response, the renal site and role of activation of this response following the insult in vivo remains largely unknown. Here we studied the renal spatio-temporal expression pattern of glucose-regulated protein (GRP) 78, a central regulator of the unfolded protein response network, following renal ischemia-reperfusion and the effects of the specific chemical unfolded protein response inducers, tunicamycin and thapsigargin, on renal ischemia-reperfusion injury in mice. Renal ischemia-reperfusion resulted in expression of the spliced form of the X-box binding protein-1 (XBP-1s) transcript, an unfolded protein response target, at 1 and 2 h after the insult. This response was followed by an increase in the GRP78 transcript and protein. The increased amount of GRP78 protein after ischemia-reperfusion was largely localized in proximal tubule cells. Pretreatment with tunicamycin or thapsigargin significantly ameliorated renal dysfunction and injury after ischemia-reperfusion. Taken together with these results, the unfolded protein response was activated following renal ischemia-reperfusion at sites that are susceptible to ischemia-reperfusion injury, and this activation had a protective effect against renal ischemia-reperfusion injury in vivo. Molecules involved in the unfolded protein response may offer new opportunities for pharmacological intervention against renal ischemia-reperfusion injury, which is an important cause of acute kidney injury. © 2008 Elsevier B.V. All rights reserved.
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Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway Reviewed
Sharyo, S., Yokota-Ikeda, N., Mori, M., Kumagai, K., Uchida, K., Ito, K., Burne-Taney, M., Rabb, H., Ikeda, M.
Kidney Int. 74 ( 5 ) 577 - 584 2008.9
Language：English Publishing type：Research paper (scientific journal)
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Therapeutic effects of the putative P2X(3)/P2X (2/3) antagonist A-317491 on cyclophosphamide-induced cystitis in rats. Reviewed
Ito, K., Iwami, A., Katsura, H., Ikeda, M.
Naunyn-Schmiedeberg's Arch. Pharmacol. 377 ( 4-6 ) 483 - 490 2008.6
Language：English Publishing type：Research paper (scientific journal)
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Glutamate mediates platelet activation through the AMPA receptor Reviewed
Morell, C.N., Sun, H., Ikeda, M., Beique, J.C., Swaim, A.M., Mason, E., Martin, T.V., Thompson, L.E., Gozen, O., Ampagoomian, D., Sprengel, R., Rothstein, J., Faraday, N., Huganir, R., Lowenstein, C.J.
J. Exp. Med. 205 ( 3 ) 575 - 584 2008.3
Language：English Publishing type：Research paper (scientific journal)
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Evaluation of olmesartan medoxomil in the rat monocrotaline model of pulmonary hypertension Reviewed
Kato, T., Nasu, T., Sonoda, H., Ito, K.-M., Ikeda, M., Ito, K.
J. Cardiovasc. Pharmacol. 51 18 - 23 2008.1
Language：English Publishing type：Research paper (scientific journal)
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Alteration of release and roles of ADP and thromboxane A2 during collagen-induced aggregation of platelets from cattle with Chediak-Higashi syndrome Reviewed
Honda, N., Ohnishi, K., Fujishiro, T., Ikeda, M., Ito, K.
Am. J. Vet. Res. 68 1399 - 1406 2007.12
Language：English Publishing type：Research paper (scientific journal)
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Honda N., Honda N., Ohnishi K., Fujishiro T., Ikeda M., Ito K.
American Journal of Veterinary Research 68 ( 12 ) 1399 - 1406 2007.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：American Journal of Veterinary Research
Objective - To compare the interaction of endogenous ADP with collagen and thromboxane A2 (TXA2) during collagen-induced platelet aggregation between platelets from healthy cattle and those with Chediak-Higashi syndrome (CHS). Population Sample - Platelets harvested from blood samples from healthy Japanese Black cattle and those with CHS. Procedures - Aggregation of gel-filtered platelets; release of ATP-ADP; and generation of thromboxane B2 (TXB2), a metabolite of TXA2, were measured. Results - The potency of collagen to induce aggregation in platelets of cattle with CHS (ie, CHS platelets) was less than a tenth of that in platelets of healthy cattle (ie, control platelets). Platelet aggregation induced by collagen at an intermediate concentration depended on the coexistence of ADP and TXA2, suggesting that released ADP cannot cause platelet aggregation by itself. Collagen-induced ADP release was markedly decreased, whereas TXB2 production was slightly low in CHS platelets, compared with that in control platelets. A combination of subthreshold amounts of ADP and 9,11-dideoxy-9α,11α-methanoepoxy-prostaglandin F2α (U46619), a TXA2 analogue, caused platelet aggregation. Similarly, a combination of subthreshold amounts of collagen and ADP caused platelet aggregation, whereas collagen and U46619 were not synergistic. Conclusions and Clinical Relevance - Deficient ADP release ensuing from the δ-storage pool deficiency in platelets from cattle with CHS resulted in reduction of collagen-induced platelet aggregation, through attenuation of synergism between TXA2 and ADP and between ADP and collagen. Furthermore, results of the study reported here indicated that TXA2 was important for aggregation of bovine platelets.
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Characterization of functional P2X1 receptors in mouse megakaryocytes Reviewed
Ikeda, M.
Thromb. Res. 119 343 - 353 2007.3
Language：English Publishing type：Research paper (scientific journal)
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Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death Reviewed
Ikeda, M., Gunji, Y., Sonoda, H., Oshikawa, S., Shimono, M., Horie, A., Ito, K., Yamasaki, S.
Eur. J. Pharmacol. 546 36 - 39 2006.9
Language：English Publishing type：Research paper (scientific journal)
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A regulatory role of polycystin-1 on cystic fibrosis transmembrane conductance regulator plasma membrane expression Reviewed
Ikeda, M., Fong, P., Cheng, J., Boletta, A., Qian, F., Zhang, X.M., Cai, H., Germino, G.G., Guggino, W.B.
Cell. Physiol. Biochem. 18 9 - 20 2006.8
Language：English Publishing type：Research paper (scientific journal)
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Ischemic acute tubular necrosis models and drug discovery: a focus on cellular inflammation Reviewed
Ikeda, M., Prachasilchai, W., Burne-Taney, M., Rabb, H., Yokota-Ikeda, N.
Drug Discov. Today 11 364 - 370 2006.4
Language：English Publishing type：Research paper (scientific journal)
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Determinants of AQP6 trafficking to intracellular sites versus the plasma membrane in transfected mammalian cells Reviewed
Beitz, E., Liu, K., Ikeda, M., Guggino, W.B., Agre, P., Yasui, M.
Biol. Cell 98 101 - 109 2006.2
Language：English Publishing type：Research paper (scientific journal)
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Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule Reviewed
Morishita, Y., Matsuzaki, T., Hara-Chikuma, M., Andoo, A., Shimono, M., Matsuki, A., Kobayashi, K., Ikeda, M., Yamamoto, T., Verkman, A., Kusano, E., Ookawara, S., Takata, K., Sasaki, S., Ishibashi, K.
Mol. Cell. Biol. 25 7770 - 7779 2005.9
Language：English Publishing type：Research paper (scientific journal)
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Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta Reviewed
Shimomura, E., Shiraishi, M., Iwanaga, T., Seto, M., Sasaki, Y., Ikeda, M., Ito, K.
Naunyn-Schmiedeberg's Arch. Pharmacol. 370 414 - 422 2004.11
Language：English Publishing type：Research paper (scientific journal)
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The cytoplasmic tail of large conductance, voltage- and Ca2+-activated K+ (MaxiK) channel is necessary for its cell surface expression Reviewed
Wang, S.X., Ikeda, M., Guggino, W.B.
J. Biol. Chem. 278 2713 - 2722 2003.1
Language：English Publishing type：Research paper (scientific journal)
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Characterization of aquaporin-6 as a nitrate channel in mammalian cells: Requirement of pore-lining residue threonine 63 Reviewed
Ikeda, M., Beitz, E., Kozono, D., Guggino, W.B., Agre, P., Yasui, M.
J. Biol. Chem. 277 39873 - 39879 2002.10
Language：English Publishing type：Research paper (scientific journal)
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Do polycystins function as cation channels? Invited Reviewed
Ikeda, M., Guggino, W.B.
Curr. Opin. Nephrol. Hypertens. 11 539 - 545 2002.9
Language：English Publishing type：Research paper (scientific journal)
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Platelet dysfunction in Chediak-Higashi syndrome-affected cattle Reviewed
Shiraishi, M., Ogawa, H., Ikeda, M., Kawashima, S., Ito, K.
J. Vet. Med. Sci. 54 751 - 760 2002.9
Language：English Publishing type：Research paper (scientific journal)
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Shiraishi M., Kawashima S., Moroi M., Shin Y., Morita T., Horii Y., Ikeda M., Ito K.
Thrombosis and Haemostasis 87 ( 2 ) 334 - 341 2002.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Thrombosis and Haemostasis
Decreased platelet aggregation to collagen is a cause for bleeding diathesis of Chediak-Higashi syndrome (CHS). We investigated whether the collagen receptor-Ca2+ signaling system was impaired in platelets from cattle affected with CHS. A collagen-induced increase in cytosolic Ca2+ ([Ca2+]i) was depressed in CHS platelets, which was accompanied by a decrease in the production of inositol 1,4,5-trisphosphate. When the influences of endogenous arachidonic acid metabolites and ADP were excluded, convulxin or collagen-related peptide, which are specific agonists for the collagen receptor GPVI, increased [Ca2+]i in both normal and CHS platelets. In contrast, rhodocytin, which was thought to activate another collagen receptor GPIa/IIa, increased [Ca2+]i in CHS platelets to a lesser extent than in normal ones. Cytochalasin D, an actin polymerization inhibitor, depressed the response to collagen or rhodocytin but not the response to convulxin. Adhesion of CHS platelets to acid soluble type I collagen, which was mediated by GPIa/IIa, was similar to that of normal platelets. These results suggest that a defect in the rhodocytin-sensitive pathway is responsible for decreasing the response to collagen in CHS platelets. It remains to be determined which receptor is associated with the mechanism.
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A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression Reviewed
Cheng, J., Moyer, B. D., Milewski, M., Loffing, J., Ikeda, M., Mickle, J. E., Cutting, G. R., Li, M., Stanton, B. A., Guggino, W. B.
J. Biol. Chem. 277 3520 - 3529 2002.2
Language：English Publishing type：Research paper (scientific journal)
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Inhibitory effect of pentalenolactone on vascular smooth muscle cell proliferation Reviewed
Ikeda, M., Fukuda, A., Takagi, M., Morita, M., Shimada, Y.
Eur. J. Pharmacol. 411 45 - 53 2001.1
Language：English Publishing type：Research paper (scientific journal)
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Inhibitory effects of ruthenium red on inositol 1,4,5-trisphosphate-induced responses in rat megakaryocytes Reviewed
Ikeda, M., Maruyama, Y.
Biochem. Pharmacol. 61 7 - 13 2001.1
Language：English Publishing type：Research paper (scientific journal)
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Shiga toxin activates p38 MAP kinase through cellular Ca2+ increase in Vero cells Reviewed
Ikeda, M., Gunji, Y., Yamasaki, S., Takeda, Y.
FEBS Lett. 485 94 - 98 2000.11
Language：English Publishing type：Research paper (scientific journal)
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Characteristics of collagen-induced Ca2+ mobilization in bovine platelets Reviewed
Shiraishi, M., Ikeda, M., Fujishiro, T., Fukuyama, K., Ito, K.
Cell Calcium 27 53 - 60 2000.1
Language：English Publishing type：Research paper (scientific journal)
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Characterization of a palytoxin-induced non-selective cation channel in mouse megakaryocytes Reviewed
Ichida, K., Ikeda, M., Goto, K., Ito, K.
Jpn. J. Pharmacol. 81 200 - 208 1999.10
Language：English Publishing type：Research paper (scientific journal)
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Detection of an autoantibody from Pug dogs with necrotizing encephalitis (Pug dog encephalitis) Reviewed
Uchida, K., Hasegawa, T., Ikeda, M., Yamaguchi, R., Tateyama, S.
Vet. Pathol. 36 301 - 307 1999.7
Language：English Publishing type：Research paper (scientific journal)
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Impaired cytosolic calcium mobilization and aggregation in response to collagen in platelets from Japanese Black cattle with Chediak-Higashi syndrome Reviewed
Shiraishi, M., Ikeda, M., Ogawa, H., Tu, C.-H., Ito, K.
Am. J. Vet. Res. 59 744 - 749 1998.6
Language：English Publishing type：Research paper (scientific journal)
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PDGF-BB decreases systolic blood pressure through an increase in macrovascular compliance in rats Reviewed
Ikeda, M., Morita, C., Mizuno, M., Sada, T., Koike, H., Kurokawa, K.
Am. J. Physiol. 273 H1719 - H1726 1997.10
Language：English Publishing type：Research paper (scientific journal)
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Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac gene expression in rats Reviewed
Kim, S., Sada, T., Mizuno, M., Ikeda, M., Yano, M., Miura, K., Yamanaka, S., Koike, H., Iwao, H.
Hypertens. Res. 20 133 - 142 1997.10
Language：English Publishing type：Research paper (scientific journal)
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Characteristics of palytoxin-induced cation currents and Ca2+ mobilization in smooth muscle cells of rabbit portal vein Reviewed
Ishii, K., Ikeda, M., Ito, K.
Naunyn-Schmiedeberg's Arch. Pharmacol. 355 103 - 110 1997.1
Language：English Publishing type：Research paper (scientific journal)
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Endothelium inhibits the palytoxin-induced depolarization and Ca2+ mobilization in porcine coronary artery through endothelium-derived hyperpolarizing factor and nitric oxide released by palytoxin Reviewed
Ishii, K., Ito, K.-M., Ikeda, M., Uemura, D., Ito, K.
Life Sci. 60 ( 7 ) 91 - 97 1997.1
Language：English Publishing type：Research paper (scientific journal)
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Nonpeptide angiotensin II receptor antagonists: Synthesis, biological activities, and structure-activity relationships of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds. Reviewed
Yanagisawa, H., Amemiya,Y., Kanazaki, T., Shimoji, Y., Fujimoto, K., Kitahara, Y., Sada, T., Mizuno, M., Ikeda, M., Miyamoto, S., Furukawa, Y., Koike, H.
J. Med. Chem. 39 ( 1 ) 323 - 338 1996.1
Language：English Publishing type：Research paper (scientific journal)
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Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. Reviewed
Mizuno, M., Sada, T., Ikeda, M., Fukuda, N., Miyamoto, M., Yanagisawa, H., Koike, H.
Eur. J. Pharmacol. 285 181 - 188 1995.10
Language：English Publishing type：Research paper (scientific journal)
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Localization of rat endothelin-converting enzyme to vascular endothelial cells and some secretory cells. Reviewed
Takahashi, M., Fukuda, K., Shimada, K., Barnes, K., Turner, A. J., Ikeda, M., Koike, H., Yamamoto, Y., Tanzawa, K.
Biochem. J. 311 657 - 665 1995.10
Language：English Publishing type：Research paper (scientific journal)
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Identification and characterization of two isoforms of an endothelin-converting enzyme-1 Reviewed
Shimada, K., Takahashi, M., Ikeda, M., Tanzawa, K.
FEBS Lett. 371 140 - 144 1995.9
Language：English Publishing type：Research paper (scientific journal)
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Ca2+ spike initiation from sensitized inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in megakaryocytes Reviewed
Ikeda, M., Kurokawa, K., Maruyama, Y.
Pflugers Arch.: Eur. J. Physiol. 427 355 - 364 1994.6
Language：English Publishing type：Research paper (scientific journal)
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Cell Ca2+ response to luminal vasopressin in cortical collecting tubule principal cells Reviewed
Ikeda, M., Yoshitomi, K., Imai, M., Kurokawa, K.
Kidney Int. 45 ( 4 ) 811 - 816 1994.3
Language：English Publishing type：Research paper (scientific journal)
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Isoproterenol stimulates Cl- current by a Gs protein-mediated process in beta-intercalated cell isolated from rabbit kidney Reviewed
Ikeda, M., Iyori, M., Yoshitomi, K., Hayashi, M., Imai, M., Saruta, T., Kurokawa, K
J. Membr. Biol. 136 ( 3 ) 231 - 241 1993.11
Language：English Publishing type：Research paper (scientific journal)
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Regulation of cortical collecting duct function: Effect of endothelin Reviewed
Kurokawa, K., Yoshitomi, K., Ikeda, M., Uchida, S., Naruse, M., Imai, M.
Am. Heart J. 125 ( 2 ) 582 - 588 1993.2
Language：English Publishing type：Research paper (scientific journal)
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Pharmacological profile of a novel 1,5-benzothiazepine calcium antagonist Reviewed
Shiga, H., Miyake, S., Ikeda, M., Ito, Y., Yanagisawa, H., Koike, H.
Arzneim-Forsch. 42 ( 5 ) 617 - 621 1992.5
Language：English Publishing type：Research paper (scientific journal)
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Cyclic nucleotide-dependent regulation of agonist-induced calcium increases in mouse megakaryocytes Reviewed
Ikeda, M., Kurokawa, K., Maruyama, Y.
J. Physiol. (Lond.) 447 711 - 728 1992.2
Language：English Publishing type：Research paper (scientific journal)
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Properties of palytoxin-induced whole cell current in single rat ventricular myocytes Reviewed
Kinoshita, K., Ikeda, M., Ito, K.
Naunyn-Schmiedeberg's Arch. Pharmacol. 344 ( 2 ) 247 - 251 1991.10
Language：English Publishing type：Research paper (scientific journal)
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Cytosolic free calcium of aorta in hypertensive rats. Chronic inhibition of angiotensin converting enzyme Reviewed
Sada, T., Koike, H., Ikeda, M., Sato, K., Ozaki, H., Karaki, H.
Hypertension 16 ( 3 ) 245 - 251 1990.9
Language：English Publishing type：Research paper (scientific journal)
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Palytoxin induces a nonselective cation channel in single ventricular cells of rat Reviewed
Ikeda, M., Mitani, K., Ito, K.
Naunyn-Schmiedeberg's Arch. Pharmacol. 337 ( 5 ) 591 - 593 1988.6
Language：English Publishing type：Research paper (scientific journal)