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Affiliation |
Faculty of Medicine School of Medicine Department of Clinical Neuroscience, Neurosurgery |
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Professor |
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TAKESHIMA Hideo
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Degree 【 display / non-display 】
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医学博士 ( 1989.3 熊本大学 )
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医学士 ( 1983.3 熊本大学 )
Research Areas 【 display / non-display 】
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Life Science / Molecular biology
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Life Science / Neurosurgery
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Life Science / Immunology
Papers 【 display / non-display 】
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Attempt of quality management seminar for clinical research by visitation in clinical departments at the University of Miyazaki Hospital: results from questionnaire survey Reviewed
Hitomi Morita, Toshihiko Yanagita, Koichiro Itai, Sosuke Iwae, Koichi Kaikita, Hideo Takeshima
50 ( suppl. 1 ) s62 - s66 2022.8
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
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Selection of surgical approach for cerebellar hemangioblastomas based on venous drainage patterns
Watanabe T., Suematsu Y., Saito K., Takeishi G., Yamashita S., Ohta H., Yokogami K., Takeshima H.
Neurosurgical Review 44 ( 6 ) 3567 - 3579 2021.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neurosurgical Review
Cerebellar hemangioblastomas remain surgically challenging because of the narrow, deep surgical corridors and tumor hypervascularity. Various surgical approaches are used according to the location, but optimal approaches have not been established. We propose a system of surgical approaches based on the venous drainage systems to facilitate surgical planning and achieve acceptable neurological outcomes. Cerebellar hemangioblastomas were divided into five types based on the main drainage systems: suboccipital hemangioblastomas draining to the transverse sinus (TS) or torcula, tentorial hemangioblastomas draining to the tentorial sinus or straight sinus, petrosal hemangioblastomas draining to the superior petrosal sinus (SPS), quadrigeminal hemangioblastomas draining to the galenic system, and tonsillar hemangioblastomas draining to the TS or torcula in conjunction with jugular bulb or SPS. Microsurgical approaches and patient outcome were retrospectively reviewed according to this classification. This study included 17 patients who underwent 21 operations for resection of 19 cerebellar hemangioblastomas, classified into 9 suboccipital, 4 tentorial, 2 petrosal, 2 quadrigeminal, and 2 tonsillar. Standard suboccipital craniotomies were utilized for suboccipital hemangioblastomas, the occipital transtentorial approach (OTA), and supracerebellar infratentorial approach for tentorial hemangioblastomas, the retrosigmoid approach for petrosal hemangioblastomas, OTA for quadrigeminal hemangioblastomas, and midline suboccipital approach for tonsillar hemangioblastomas. Gross total resection was achieved in all patients except one. Two patients with large hemangioblastomas (tonsillar and quadrigeminal) required second-stage operation which finally achieved gross total removal. No single approach had a significantly higher incidence of postoperative neurological deficits. Selection of the optimum surgical approach for cerebellar hemangioblastomas was successful based on the main drainage systems. Understanding of tumor growth and extension with respect to the venous drainage system is critical to select the appropriate surgical approach.
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12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro-oncology 2021.10
Language：English Publishing type：Research paper (scientific journal)
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Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study
Mizobuchi Y., Nagahiro S., Kondo A., Arita K., Date I., Fujii Y., Fujimaki T., Hanaya R., Hasegawa M., Hatayama T., Inoue T., Kasuya H., Kobayashi M., Kohmura E., Matsushima T., Masuoka J., Morita A., Nishizawa S., Okayama Y., Shigeno T., Shimano H., Takeshima H., Yamakami I.
Neurosurgery 89 ( 4 ) 557 - 564 2021.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neurosurgery
BACKGROUND: Microvascular decompression (MVD) is the most effective procedure for the long-term management of trigeminal neuralgia (TGN). However, retrospective and single-center studies are inherently biased, and there are currently no prospective, multicenter studies. OBJECTIVE: To evaluate the short- and long-term outcomes and complications in patients with TGN who underwent MVD at specialized Japanese institutions. METHODS: We enrolled patients with TGN who underwent MVD between April 2012 and March 2015. We recorded their facial pain grade and complications at 7 d (short term), 1 yr (mid-term), and 3 yr (long term) postoperatively. RESULTS: There were 166 patients, comprising 60 men and 106 women (mean age 62.7 yr). Furthermore, 105 patients were aged over 60 yr. We conducted neuromonitoring in 84.3% of the cases. The complete pain relief, mortality, and complication rates at the short-term follow-up were 78.9%, 0%, and 16.3%, respectively. Overall, 155 patients (93.4%) completed the long-term follow-up, with the complete pain relief and complication rates of 80.0% and 5.2%, respectively. CONCLUSION: In the hands of experienced neurosurgeons, MVD for TGN can achieve high long-term curative effects. In addition, complications are uncommon and usually transient. Our results indicate that MVD is an effective and safe treatment for patients with TGN, including elderly patients.
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Glioblastoma mimicking metastatic small cell carcinoma: A case report with ultrastructural findings
Maekawa K., Tokumitsu T., Noguchi H., Nakamura E., Gi T., Horinouchi S., Yamashita S., Takeshima H., Asada Y., Sato Y.
Diagnostic Cytopathology 49 ( 8 ) E291 - E296 2021.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Diagnostic Cytopathology
It is often straightforward to distinguish glioblastoma (GBM) from metastatic carcinoma by cytology; however, small cell variants of GBM or GBM with primitive neuronal component (GBMPNC) can mimic metastatic small cell carcinoma (SCC). Herein, we report a case of GBMPNC mimicking metastatic SCC and present cytological and ultrastructural findings. A 65-year-old man with memory disturbance was hospitalized. Magnetic resonance imaging revealed the presence of a 6 cm sized tumor in the right anterior temporal lobe. Intraoperative cytology slides indicated that the tumor consisted of small-sized cells with scant cytoplasm showing high cellularity. The initial intraoperative diagnosis was metastatic SCC; however, any primary visceral tumor was not detected clinically. Immunohistochemical and ultrastructural studies of postoperative histological sections revealed that the lesion was GBMPNC. This case shows that some GBMs may have the potential to closely mimic metastatic SCC, which expands the differential diagnosis and emphasizes the importance of clinical correlation.
DOI： 10.1002/dc.24715
Books 【 display / non-display 】
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ニュースタンダード脳神経外科
竹島秀雄、外（ Role： Joint author）
三輪書店 2017
Language：Japanese Book type：Textbook, survey, introduction
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病気がみえる Vol.7 脳・神経 第2版
竹島秀雄、外（ Role： Joint author）
メディックメディア東京 2017
Language：Japanese
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病気がみえる Vol.7 脳・神経 第2版
竹島秀雄、外（ Role： Joint author）
メディックメディア東京 2017
Language：Japanese
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ニュースタンダード脳神経外科
竹島秀雄、外（ Role： Joint author）
三輪書店 2017
Language：Japanese Book type：Textbook, survey, introduction
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脳腫瘍診療ガイドライン① 成人膠芽腫・成人転移性脳腫瘍・中枢神経系原発悪性リンパ腫
竹島秀雄、外（ Role： Joint author）
金原出版 2016.7
Language：Japanese
MISC 【 display / non-display 】
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Hasegawa M., Hatayama T., Kondo A., Nagahiro S., Fujimaki T., Amagasaki K., Arita K., Date I., Fujii Y., Goto T., Hanaya R., Higuchi Y., Hongo K., Inoue T., Kasuya H., Kayama T., Kawashima M., Kohmura E., Maehara T., Matsushima T., Mizobuchi Y., Morita A., Nishizawa S., Noro S., Saito S., Shimano H., Shirane R., Takeshima H., Tanaka Y., Tanabe H., Toda H., Yamakami I., Nishiyama Y., Ohba S., Hirose Y., Suzuki T.
World Neurosurgery 134 685 2020.2
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：World Neurosurgery
The authors regret in the original article, there were some mistakes in Table 4 as published. The materials used at redo operation and numbers were placed incorrectly. The materials used at redo operation should be in the second column and the number should be in the third column. The corrected Table 4 appears below. [Table presented] The authors would like to apologise for any inconvenience caused.
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脳腫瘍 [特集]化学放射線療法
竹島秀雄，倉津純一
Mebio Oncology 2 ( 4 ) 12 - 19 2005.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：メジカルビュー社
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Expression of interleukin-6 in human craniopharyngiomas: A possible inducer of tumor-associated inflammation
TAKESHIMA Hideo
Int J Mol Med 14: 505-509 2004
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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悪性脳腫瘍の化学療法
竹島秀雄，倉津純一
脳神経外科 31 ( 7 ) 725 - 734 2003.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：医学書院
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専門医に求められる最新の知識，神経線維腫症のupdate
竹島秀雄，倉津純一
脳神経外科速報 13 ( 5 ) 499 - 505 2003.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：メディカ出版
Presentations 【 display / non-display 】
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Microvascular decompression for hemifacial spasm associated with vertebralartery: Personal opinionfor choice of the method for VA-decompression. International conference
Takeshima H
The 15th Kyushyu and Yong-Honam Neurosurgical Joint Meeting
Event date： 2018.11
Language：English Presentation type：Oral presentation (general)
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脳卒中とは？
竹島秀雄
第10回日本脳卒中協会宮崎県支部市民公開講座
Event date： 2018.5.26
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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脳卒中とは？
竹島秀雄
第9回日本脳卒中協会宮崎県支部市民公開講座
Event date： 2017.5.27
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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視床・視床下部から発生したと考えられるatrypical teratoid/rhabdoid tumor(AT/RT)の一例．
天達俊博，篠島直樹，三上芳喜，横尾英明，森武浩，竹島秀雄，矢野茂敏
第125回日本脳神経外科学会九州支部会
Event date： 2017.3.11
Language：Japanese Presentation type：Oral presentation (general)
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Detection of p53 mutation in proliferating vascular cell in glioblastoma multiforme. International conference
Takeshima H, Kawasoe T, Yamashita S, Yokogami K, Yamasaki K.
14th Young-Honam and Kyushu neurosurgical joint meeting
Event date： 2016.11.11 - 2016.11.12
Language：English Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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代謝経路再編成が概日リズム経路を介し、幹細胞性維持、細胞死回避に及ぼす影響の解明
Grant number：22K09262 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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毛様細胞性星細胞腫における増殖血管内皮の起源の解明
2016.04 - 2019.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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癌幹細胞分化誘導システムを利用した乏突起膠腫の新規分子マーカーの探索
2008.04 - 2011.03
科学研究費補助金 基盤研究(B)
Authorship：Principal investigator
乏突起膠腫の特異的分子マーカーを同定するため、癌幹細胞を分化誘導させ、その発現分子の違いから探索する。
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悪性グリオーマにおける免疫抑制機構の解明と自殺キメラ分子を用いた腫瘍免疫賦活療法
2005.04 - 2008.03
科学研究費補助金 基盤研究(B)
Authorship：Principal investigator
グリオーマ組織中にリンパ球の浸潤が少ないのは、腫瘍の維持する免疫抑制機構が存在するためであるが、これを抑制することで腫瘍免疫を不活化することを目的として、免疫抑制機構の解析を行っている。
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KIT分子を標的とした中枢神経系胚芽腫の診断と治療法の開発
2003.04 - 2005.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
胚腫においてc-kitが高レベルに発現していることより、この分子の髄液中soluble formが上昇していることを明らかにし、新たな腫瘍マーカーとなりうることを示した。また、このリガンドであるSCFの発現もc-kitと同じパターンで見られた。さらに、SCFの髄液中濃度も腫瘍マーカーとなりうる可能性が示唆された。
Available Technology 【 display / non-display 】
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Related fields where technical consultation is available：網羅的解析、in vitro 実験
