Details of a Researcher

Three-dimensional fine structures in deep fascia revealed by combined use of cryo-fixed histochemistry and low-vacuum scanning microscopy

Imazato H., Takahashi N., Hirakawa Y., Yamaguchi Y., Hiyoshi M., Tajima T., Chosa E., Sawaguchi A.

Scientific Reports 13 ( 1 ) 6352 2023.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Scientific Reports

Recent physiological studies have shown that the deep fascia has received much attention concerning clinical medicine; however, histological examination of the deep fascia has not been well established. In this study, we aimed to clarify and visualize the structure of the deep fascia by taking advantage of cryofixation techniques and low-vacuum scanning electron microscopy. As a result, the ultrastructural observations revealed three-dimensional stratification of the deep fascia composed of three layers: the first superficial layer consisting of collagen fibers extending in various directions with blood vessels and peripheral nerves; the second intermediate layer formed by single straight and thick collagen fibers with flexibility; and the third deepest layer, consisting of relatively straight and thin collagen fibers. We explored the use of two hooks to hold a piece of deep fascia in place through the course of cryo-fixation. A comparative observation with or without the hook-holding procedure would indicate the morphological adaptation to physiological stretch and contraction of the deep fascia. The present morphological approach paves the way to visualize three-dimensional ultrastructures for future biomedical studies including clinical pathophysiology.

DOI： 10.1038/s41598-023-33479-3

Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway

Nagai T., Sekimoto T., Kurogi S., Ohta T., Miyazaki S., Yamaguchi Y., Tajima T., Chosa E., Imasaka M., Yoshinobu K., Araki K., Araki M., Choijookhuu N., Sato K., Hishikawa Y., Funamoto T.

Scientific Reports 13 ( 1 ) 14639 2023.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports

Bone remodeling is an extraordinarily complex process involving a variety of factors, such as genetic, metabolic, and environmental components. Although genetic factors play a particularly important role, many have not been identified. In this study, we investigated the role of transmembrane 161a (Tmem161a) in bone structure and function using wild-type (WT) and Tmem161a-depleted (Tmem161aGT/GT) mice. Mice femurs were examined by histological, morphological, and bone strength analyses. Osteoblast differentiation and mineral deposition were examined in Tmem161a-overexpressed, -knockdown and -knockout MC3T3-e1 cells. In WT mice, Tmem161a was expressed in osteoblasts of femurs; however, it was depleted in Tmem161aGT/GT mice. Cortical bone mineral density, thickness, and bone strength were significantly increased in Tmem161aGT/GT mice femurs. In MC3T3-e1 cells, decreased expression of alkaline phosphatase (ALP) and Osterix were found in Tmem161a overexpression, and these findings were reversed in Tmem161a-knockdown or -knockout cells. Microarray and western blot analyses revealed upregulation of the P38 MAPK pathway in Tmem161a-knockout cells, which referred as stress-activated protein kinases. ALP and flow cytometry analyses revealed that Tmem161a-knockout cells were resistant to oxidative stress. In summary, Tmem161a is an important regulator of P38 MAPK signaling, and depletion of Tmem161a induces thicker and stronger bones in mice.

DOI： 10.1038/s41598-023-41837-4

Increasing baseline aortic valve peak flow velocity is associated with progression of aortic valve stenosis in osteoporosis patients—a possible link to low vitamin D status

Tsuruda T., Funamoto T., Suzuki C., Yamamura Y., Nakai M., Chosa E., Kaikita K.

Archives of Osteoporosis 18 ( 1 ) 129 2023.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Archives of Osteoporosis

Purpose: The purpose of this study was to investigate the morphological characteristics of the aortic valve and identify factors associated with the progression of aortic valve stenosis (AS) in osteoporosis patients. Methods: In this single-center prospective cohort study, we recruited 10 patients (mean age: 75 ± 7 years, 90% female) who were taking anti-resorptive medicines at the outpatient clinic of University of Miyazaki Hospital, Japan. Baseline assessments, including transthoracic echocardiogram, blood sampling, and dual energy X-ray absorptiometry, were performed. Follow-up assessments were conducted at 6, 12, 18, and 24 months. Results: During the 2-year follow-up, three patients with aortic valve peak flow velocity (AV PFV) ≥2 m/s at baseline developed moderate AS, which is defined as AV PFV ≥3 m/s. However, seven patients with AV PFV <2 m/s did not exhibit any progression of AS. There were significant variations in terms of bone mineral density, T-score values, and biomarkers associated with bone turnover (i.e., bone alkaline phosphatase, tartrate-resistance acid phosphatase-5b) among the enrolled patients, but none of these factors were found to be associated with the progression of AS. All patients exhibited low vitamin D status, with a median level of 16.1 ng/mL (25th percentile, 9.7 ng/mL; 75th percentile, 23 ng/mL). The baseline levels of AV PFV values were negatively correlated with 25-hydroxyvitamin D levels, determined by univariate linear regression analysis (beta coefficient = -0.756, 95% confidence interval, -0.136 ̶ -0.023, p = 0.011). Conclusion: Our data suggest that low vitamin D status might be a potential risk factor for the progression of AS in osteoporosis patients undergoing treatment with anti-resorptive medicines. Summary : Elderly patients with osteoporosis patients exhibited a subset of aortic valve stenosis. Our data suggest that the baseline aortic valve peak flow velocity predicts the progression of aortic valve stenosis, and there might be an association between the progression and the co-existing low vitamin D status in these patients.

DOI： 10.1007/s11657-023-01339-2

特集偽関節治療のエキスパートを目指そう introduction

帖佐悦男

関節外科　基礎と臨床 42 ( 11 ) 1201 - 1201 2023.11

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000001580

特集偽関節治療のエキスパートを目指そう偽関節の保存療法

日吉優, 帖佐悦男

関節外科　基礎と臨床 42 ( 11 ) 1219 - 1226 2023.11

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000001583

Diagnostic utility of anteroposterior measurements of the median nerve on sagittal ultrasonographic images and their correlation with clinical findings in carpal tunnel syndrome

Okura T., Tajima T., Fukuda H., Matsuoka T., Chosa E.

Journal of Clinical Ultrasound 51 ( 9 ) 1522 - 1528 2023.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Clinical Ultrasound

Purpose: To investigate the efficacy of sagittal ultrasonography of the median nerve in diagnosing carpal tunnel syndrome (CTS). Methods: Seventy-six hands with idiopathic CTS and 80 hands of asymptomatic subjects were included. All patients with CTS underwent ultrasonographic examination, electrodiagnostic testing, and CTS-6 assessment. In the sagittal ultrasonographic examination, the maximum and minimum median nerve diameters (MNDs) were measured at the proximal and distal ends of the carpal tunnel, respectively. The median nerve stenosis rate (MNSR) was computed as (1 – minimum MND/maximum MND) × 100 (%). The cross-sectional area (CSA) of the median nerve at the level of the pisiform was measured. Results: In the sagittal ultrasonographic examination, the mean maximum MNDs were 0.252 cm and 0.202 cm, mean minimum MNDs were 0.145 cm and 0.165 cm, and mean MNSRs were 41.83% and 17.35% in the CTS and control groups, respectively; the mean maximum MND and MNSR were considerably larger in the CTS group. The maximum MND and MNSR were correlated with the electrodiagnostic testing results and CTS-6 score. The MNSR with a cut-off value of 34.0% had a higher sensitivity and specificity than the CSA in diagnosing CTS. Conclusions: Sagittal ultrasonographic examination is useful in diagnosing CTS.

DOI： 10.1002/jcu.23584

特集変形性関節症の最新の治療戦略 Ⅱ　各論人工関節置換術人工股関節置換術(THA)に対する最新のトレンド−下肢牽引台を用いた最小侵襲アプローチ｢intra-capsular THA｣に関して−

中村嘉宏, 帖佐悦男

関節外科　基礎と臨床 42 ( 14 ) 147 - 156 2023.10

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000001568

Effect of age on upper limb, neck, and trunk kinematics during activities of daily living

Nakatake J., Arakawa H., Shogo M., Totoribe K., Chosa E.

Heliyon 9 ( 10 ) e20535 2023.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Heliyon

Motion analysis during activities of daily living has been conducted in numerous studies. However, information is lacking regarding age-related differences that affect clinical assessment and treatment goals. This study aimed to examine the effect of age on kinematics during activities of daily living. Three-dimensional motions of the shoulder, elbow, neck, and trunk of 12 younger adults (age, 29.8 ± 5.4 years; 7 men and 5 women) and 10 older adults (age, 69.5 ± 4.9 years; 6 men and 4 women) were measured during the acts of reaching for a table, bringing a glass to the mouth for drinking, wiping the buttocks, tying shoelaces, washing hair, washing the axilla, reaching for a high shelf, and reaching for the floor. The ranges of motion and sequential joint angles were compared between age groups by using discrete analysis and statistical parametric mapping, respectively. The ranges of motion of all joint angles in older and younger adults were comparable in the drinking, washing hair, washing the axilla, and reaching for the floor tasks. Statistical parametric mapping indicated that older adults had significantly poorer neck extension than did younger adults during the drinking (67–92% cycle time) and tying shoelaces (64–95% cycle time) tasks. Kinematics were mostly maintained in healthy older adults during activities of daily living. However, reduced motions were confirmed later during some tasks. The results indicated that existing knowledge combined with the current findings, which take age into account, could be used in clinical settings to assess the kinematics of activities of daily living and set treatment goals.

DOI： 10.1016/j.heliyon.2023.e20535

頚部傍脊椎領域原発悪性リンパ腫に対し椎弓形成術を施行した小児の1例

飯田暁人, 濱中秀昭, 黒木修司, 比嘉聖, 永井琢哉, 黒木智文, 日髙三貴, 帖佐悦男

整形外科と災害外科 72 ( 4 ) 735 - 738 2023.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【はじめに】非常に稀な小児頚部傍脊椎領域原発悪性リンパ腫に対し，椎弓形成術を施行した症例を報告する．【症例】12歳，男児．1か月前より頚部痛あり，徐々に上肢麻痺（MMT3），巧緻運動障害が出現し紹介となった．MRIでC3-6の椎体から椎弓にかけての腫瘍性病変と脊髄腫大を認めた．受診翌日にC3-6の椎弓形成を行い，前駆B細胞性リンパ芽球性リンパ腫と診断された．小児科にて化学療法施行後，C3-6に対し陽子線を18 Gy照射した．現在術後4年で麻痺なく，寛解を維持している．最終観察時C2-7角は11度であった．陽子線照射にもかかわらず，脂肪髄化した椎体がリモデリングし，椎体高も1椎体平均4.15 mm成長した．【考察】小児に対する頚椎椎弓形成術や陽子線治療後の椎体成長に関する報告は少ない．小児腫瘍は予後が改善してきており，骨成長や変形に対しても長期に経過観察する必要がある．

DOI： 10.5035/nishiseisai.72.735

腰椎前側方固定術後のインストゥルメント周囲感染の治療経験

鮫島央, 濱中秀昭, 黒木修司, 比嘉聖, 永井琢哉, 黒木智文, 日髙三貴, 帖佐悦男

整形外科と災害外科 72 ( 4 ) 749 - 753 2023.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

症例は85歳，男性．近医にて腰部脊柱管狭窄症，腰椎辷り症に対しL4/5の腰椎前外側椎体間固定術（以下，OLIF）を施行された．術直後に発熱と腰痛が出現し，画像検査にてインストゥルメント周囲感染と診断され，後方からの洗浄デブリードマンや固定延長を行うも感染コントロール不良なために術後6か月で当科紹介となった．当科にてケージ抜去・前方掻爬自家骨移植術・後方固定術を施行した．その後，起炎菌は同定できなかったが長期の抗生剤内服を併用したことで感染は沈静化し疼痛も消失しADLも改善した．脊椎インストゥルメンテーション手術後の感染の治療は感染制御と脊椎安定性の維持の2つの柱のバランスを踏まえて行う必要がある．しかし，エビデンスに基づいた治療が確立されていないのが現状である．脊椎インストゥルメント周囲感染について最近の知見を踏まえ当院での治療方針に関して検討したので報告する．

DOI： 10.5035/nishiseisai.72.749

股関節高位脱臼に対して大腿骨遠位短縮骨切りを併用した人工股関節再置換術の1例

座間味陽, 中村嘉宏, 坂本武郎, 舩元太郎, 日吉優, 山口洋一朗, 今里浩之, 平川雄介, 帖佐悦男

整形外科と災害外科 72 ( 3 ) 424 - 426 2023.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

股関節高位脱臼に対して大腿骨遠位短縮骨切り術を併用した1例を経験したので報告する．【症例】72歳女性，1980年に左人工股関節置換術（以下THA），以降，右THA並びに2003年に左THA（Depuy AML）を施行．徐々に左股関節痛の増悪を認め，X線にて高度寛骨臼骨欠損に伴うカップの高位脱臼を認めた．手術は同種骨移植後原臼位にセメントレスカップを設置．Well fixed状態のためステムは温存し，大転子移動量70mmであったため大腿骨遠位35mm短縮骨切り術を併用．術後麻痺なく経過した．【考察】広く転子下骨切り術は併用される一方，既存ステム挿入例や近位高度骨変形などでは遠位骨切りも選択肢の一つとなり得る．

DOI： 10.5035/nishiseisai.72.424

第2趾DIP関節脱臼に対する観血的整復術後の早期スポーツ復帰の一例

川越亮, 田島卓也, 山口奈美, 大田智美, 長澤誠, 森田雄大, 横江琢示, 帖佐悦男

整形外科と災害外科 72 ( 3 ) 485 - 487 2023.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【はじめに】観血的整復術を必要とした第2趾のDIP関節脱臼の1例を経験した．【症例】16歳男性．空手中に受傷．第2趾DIP関節脱臼で徒手整復を行ったが整復不能であったため，観血的整復術を行った．整復阻害因子は長趾屈筋腱であり，蹠側板の嵌頓は認めなかった．術後早期の競技復帰希望があったため母趾とのbuddy tapingを指示し復帰とした．術後6か月が経過し特に問題なく競技継続している．【考察】DIP関節脱臼の整復阻害因子は蹠側板や長趾屈筋腱の報告があり，本症例では長趾屈筋腱であった．また，術後のスポーツ復帰について，競技によっては症状次第で早期復帰が見込めると考えられた．

DOI： 10.5035/nishiseisai.72.485

Is the Small Ossicle of Type 1 Accessory Navicular a Cause of Foot Pain?—A Case Report

Yokoe T., Uemichi K., Tajima T., Chosa E.

Medicina (Lithuania) 59 ( 9 ) 2023.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Medicina (Lithuania)

Background and objectives: An accessory navicular (AN) bone is often classified into types 1–3 according to the Veitch classification, and symptomatic type 1 patients usually receive non-surgical treatment. However, there are cases in which AN cannot be classified into one of these three types using this classification system, and the small ossicle of type 1 AN may not be the cause of foot pain. This report aimed to present a case of symptomatic type 1 AN that required surgical treatment without the excision of the small ossicle after long-term conservative treatment had failed. Case presentation: A 15-year-old girl who was diagnosed with symptomatic type 1 AN was referred to our department. Medial-side foot pain had prevented her from playing soccer well. She had been treated conservatively for type 1 AN for more than 12 months at several orthopedic clinics. Tenderness of the prominent navicular tubercle was identified, and computed tomography and magnetic resonance imaging findings suggested that the cause of her foot pain was derived from the prominent navicular tubercle not the small ossicle itself. Osteotomy of the prominent navicular tubercle with the advancement of the tibialis posterior tendon, without excision of the ossicle, was performed. At the 12-month follow-up examination, she was completely free from foot pain, and the patient-reported outcome measures were excellent. She now plays soccer at the pre-injury level. Conclusions: We report the case of a patient with symptomatic type 1 AN who underwent osteotomy of the prominent navicular tubercle with advancement of the tibialis posterior tendon, without excision of the ossicle, and who showed favorable short-term clinical outcomes. The evaluation of symptomatic patients with AN based on the Veitch classification alone may lead to inappropriate management. The small ossicle of type 1 AN was not the cause of foot pain in the present case.

DOI： 10.3390/medicina59091562

Shear stress in the medial meniscus posterior root during daily activities

Yokoe T., Ouchi K., Yamaguchi Y., Enzaki M., Tajima T., Chosa E.

Knee 43 176 - 183 2023.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Knee

Background: Medial meniscus posterior root (MMPR) tears have been reported to occur in middle-aged patients with minor trauma. However, the injury mechanism of MMPR tears remains unclear. The purpose of this study was to evaluate the shear stress in the MMPR during daily activities using a finite-element analysis. Methods: Subject-specific finite-element models of the knee joint of a healthy middle-aged subject were developed from computed tomographic and magnetic resonance images. A three-dimensional motion capture system “VICON” was used to capture four daily activities: walking, jogging, descending stairs, and landing. The knee joint reaction force was estimated using the AnyBody modeling system. Based on these procedures, the shear stress in the MMPR was calculated during each motion. The shear stress in the lateral meniscus posterior root (LMPR) was also measured to compare the stress between the MMPR and LMPR. Results: The shear stress in the MMPR increased as the knee flexion angle increased during each motion. Descending stairs caused more than two-fold greater stress in the MMPR than walking and a similar or greater amount of stress than jogging. The LMPR tended to receive more shear stress than the MMPR throughout each motion. Conclusions: The present study showed that descending stairs confers almost the same amount of shear stress to the MMPR as jogging. The results of the present study may suggest that descending motion of the knee is an important cause of MMPR tear, and the initiation of descending stairs should be delayed after MMPR repair.

DOI： 10.1016/j.knee.2023.06.008

書評『ナショナルチームドクター･トレーナーが書いた種目別スポーツ障害の評価とリハビリテーション』

帖佐悦男

整形外科 74 ( 8 ) 892 - 892 2023.7

Publishing type：Research paper (scientific journal) Publisher：南江堂

DOI： 10.15106/j_seikei74_892

宮崎式サーフィン競技安全度評価を1シーズン使用してみて Reviewed

小島岳史、柏木輝行、柏木悠吾、福嶋研人、吉田尚紀、石田翔太郎、帖佐悦男、田島卓也

九州・山口　スポーツ医・科学研究会誌 34 28 - 32 2023.7

Publishing type：Research paper (scientific journal)

特集変形性関節症の診断と治療--保存的治療から再生医療まで Ⅵ章.変形性股関節症 3.変形性股関節症の画像診断(X線像,CT,MRIなど)

帖佐悦男

整形外科 74 ( 6 ) 609 - 615 2023.5

Publishing type：Research paper (scientific journal) Publisher：南江堂

DOI： 10.15106/j_seikei74_609

脆弱性骨折に対する当院の取り組み―活動を見直し，OLSからFLSに的を絞って得られた効果についての検討― Reviewed

小牧亘、帖佐悦男

骨折 45 ( 3 ) 936 - 940 2023.5

Language：Japanese Publishing type：Research paper (scientific journal)

Ureter position and risk of ureteral injury during lateral lumbar interbody fusion Reviewed

Hideaki Hamanaka,Takuya Tajima,Syuji Kurogi,Kiyoshi Higa, Takuya Nagai,Tomofumi Kuroki,Hiroki Takamori, Syoichiro Mukai,Toshiyuki Kamoto,Etsuo Chosa

Journal of Orthopaedic Science 2023.5

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Retrograde Autologous Talar Osteocancellous Bone Grafting for the Treatment of Osteochondral Lesions of the Talus: A Technical Note Reviewed

Takuji Yokoe,Takuya Tajima,Nami Yamaguchi,Yudai Morita,Etsuo Chosa

Journal of Clinical Medicine 2023.5

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Risk factors associated with throwing injuries in young baseball players Reviewed

Makoto Nagasawa,MD,Takuya Tajima,MD,PhD,Shuichi Kawagoe,MD,Nami Yamaguchi,MD,PhD, Yudai Morita,MD,Takuji Yokoe,MD,Tomomi Ota,MD,Toshihiko Izumi, MD, PhD,Yasuyuki Ishida,MD,Etsuo Chosa,MD,PhD

Journal of Clinical Medicine 2023.5

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

人工関節における進歩 Ⅶ.インプラント抜去人工股関節再置換術における合併症対策

中村嘉宏, 帖佐悦男

別冊整形外科 1 ( 83 ) 164 - 170 2023.4

Publishing type：Research paper (scientific journal) Publisher：南江堂

DOI： 10.15106/j_besei83_164

Evaluation of Sit-to-Stand Movement in Older Adults with Locomotive Syndrome Using the Nintendo Wii Balance Board

Yamako G., Punchihewa N.G., Arakawa H., Tajima T., Chosa E.

Sensors 23 ( 7 ) 2023.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Sensors

Standing up from a chair is a mechanically demanding daily motion, and its biomechanics represent motor performance. In older adults with locomotive syndrome (LS), sit-to-stand (STS) movement with adequate postural control is essential to prevent falls. This study evaluated the characteristics of dynamic balance during STS movement on older adults with LS. A total of 116 participants aged ≥65 years were divided into Non-LS, LS stage 1, and LS stage 2 groups using the LS risk test. The participants were instructed to stand on the Nintendo Wii Balance Board as quickly as possible, and the STS movement was quantified using the vertical ground reaction force (VGRF) and center of pressure (CoP). The STS score, which represented dynamic balance, was significantly different among the groups (p < 0.001). The rate of VGRF development was significantly lower in the LS stages 1 and 2 than in the Non-LS group (p < 0.001). On the other hand, the total distance of the CoP path did not differ among the groups (p = 0.211). These findings indicated a reduction of postural control in older adults with LS. The STS score emphasized the importance of balance training to prevent falls in older adults with LS.

DOI： 10.3390/s23073368

Effect of the volume of resected discoid lateral meniscus on the contact stress of the tibiofemoral joint: A finite element analysis. Reviewed

Yokoe T, Ouchi K, Matsumoto T, Tajima T, Chosa E

The Knee 42 57 - 63 2023.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Knee

Background: Partial meniscectomy is commonly performed for symptomatic patients with discoid lateral meniscus (DLM) if conservative treatment fails. However, the development of knee osteoarthritis and osteochondral lesion are detrimental postoperative complications. This study aimed to evaluate the effect of the volume of resected DLM on the contact stress of the tibiofemoral joint using a finite element analysis. Methods: Subject-specific finite-element models of the knee joint of a patient with DLM were developed from computed tomographic and magnetic resonance images. To evaluate the effect of partial meniscectomy on the contact stress in the lateral tibiofemoral joint, six knee models were created in the study (the native DLM, and five partially meniscectomized DLMs (according to the preserved width of the meniscus: 12 mm, 10 mm, 8 mm, 6 mm, and 4 mm)). Results: As the volume of resected DLM increased, higher contact stress was applied to the lateral tibiofemoral joint. Greater contact stress was applied to the preserved lateral meniscus than to the native DLM. Conclusions: From a biomechanical viewpoint, the native DLM was the most protective against lateral tibiofemoral contact stress in comparison to partially meniscectomized DLMs.

DOI： 10.1016/j.knee.2023.02.013

Effect of the volume of resected discoid lateral meniscus on the contact stress of the tibiofemoral joint: A finite element analysis Reviewed

Takuji Yokoe, Koki Ouchi, Taisei Matsumoto, Takuya Tajima, Etsuo Chosa

The Knee 57 - 63 2023.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier

DOI： 10.1016/j.knee.2023.02.013

Risk factors associated with throwing injuries in young baseball players. Reviewed

Nagasawa M, Tajima T, Kawagoe S, Yamaguchi N, Morita Y, Yokoe T, Ota T, Izumi T, Ishida Y, Chosa E

Journal of shoulder and elbow surgery 32 ( 8 ) 1673 - 1680 2023.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Shoulder and Elbow Surgery

Background: Few studies have retrospectively analyzed the relationship between joint range of motion (ROM) and muscle flexibility and shoulder and elbow throwing injuries in a large number of elementary school baseball players. The purpose of this study was to retrospectively identify the physical factors related to shoulder and elbow throwing injuries in younger baseball players. Methods: A total of 2466 younger baseball players belonging to our Prefecture Rubber Baseball Federation who participated in medical check-ups from 2016 to 2019 were analyzed. Players completed a questionnaire and had a medical check-up that included a physical examination and ultrasonography. ROM (internal rotation [IR] angle and external rotation angle) of the shoulder and hip and the finger-to-floor distance and heel-to-buttock distance were measured. The straight leg raise was also performed. The results of two groups (normal group and injury group) were compared using the χ2 test, Mann-Whitney U test, and Student t test. Stepwise forward logistic regression models were developed to identify risk factors. Results: On univariate analysis, nine of the 13 evaluated items showed significant decreases in ROM and muscle flexibility in the injury group. On multiple logistic regression analysis, grade, finger-to-floor distance, IR angle of the dominant side shoulder, and IR angle of the nondominant side hip were significantly associated with the occurrence of throwing injuries. Decreased total shoulder angle was observed not only on the dominant side but also on the nondominant side in the injury group. Conclusion: Decreased ROM and muscle flexibility were risk factors for baseball-related throwing injuries in elementary school baseball players. To prevent shoulder and elbow throwing injuries, players, coaches, medical staff, and parents need to be aware of these findings.

DOI： 10.1016/j.jse.2023.01.034

A Traumatic Neuroma Formation Following Fasciotomy for the Treatment of Tibialis Anterior Muscle Herniation:A Case Report Reviewed

Insertion sites of the muscles attached to the clavicle: a cadaveric study of the clavicle Reviewed

Hiroyuki Imazato, Nobuyasu Takahashi, Akira Sawaguchi, Yusuke Hirakawa, Yoichiro Yamaguchi, Masaru Hiyoshi, Takuya Tajima & Etsuo Chosa

BMC Musculoskeletal Disorders 2023.3

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC

DOI： 10.1186/s12891-023-06266-4

Takuji Yokoe,Takuya Tajima,Nami Yamaguchi,Yudai Morita and Etsuo Chosa

medicina 59 ( 3 ) 2023.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Medicina (Lithuania)

Muscle herniation of the lower extremity, such as tibialis anterior muscle herniation (TAMH), is not a rare cause of leg pain in athletes. However, a few studies have reported surgical treatment for TAMH, and the optimal surgical procedure remains controversial. Fasciotomy was reported to be effective for patients with TAMH. However, this procedure would be associated with a risk of intraoperative injury to the superficial peroneal nerve (SPN), although no previous literature has reported this complication. This case report aimed to report a case of bilateral TAMHs in which a traumatic neuroma of the SPN developed after fasciotomy. A 16-year-old baseball player presented with painful swelling lesions of the bilateral lower extremities (1 lesion on the right, 3 lesions on the left) after sports activities. An ultrasonographic evaluation showed swelling lesions of the anterolateral parts of the bilateral lower extremities in the standing position after dashing, while these lesions were not detected in the supine position. A fasciotomy of the crural fascia was performed after conservative treatment failed. Several days after surgery, the patient presented with weakened touch sensation over the dorsal area of the left foot. At the three-month follow-up examination, a swelling lesion with hard elasticity was identified. The palpation of this lesion caused a radiating sensation in the area supplied by the SPN. He was able to return to playing baseball six months after surgery. The patient was asymptomatic without palpation of the traumatic neuroma of the SPN at the latest follow-up examination. In conclusion, the present case report suggests that orthopedic surgeons need to consider the risk of iatrogenic injury to the SPN during fasciotomy for the treatment of TAMHs. However, there may be a risk of injuring the SPN because of the many variants of the course of the SPN within the compartment of the lower extremities.

DOI： 10.3390/medicina59030466

第6回日本リハビリテーション医学会秋季学術集会【印象記】／第6回日本リハビリテーション医学会秋季学術集会【報告記】

帖佐悦男, 千田益生

The Japanese Journal of Rehabilitation Medicine 60 ( 2 ) 167 - 168 2023.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：公益社団法人日本リハビリテーション医学会

DOI： 10.2490/jjrmc.60.167

Influence of the Tibial Tunnel Angle and Posterior Tibial Slope on "Killer Turn" during Posterior Cruciate Ligament Reconstruction: A Three-Dimensional Finite Element Analysis. Reviewed

Yang F, Yokoe T, Ouchi K, Tajima T, Chosa E

Journal of clinical medicine 12 ( 3 ) 2023.1

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3390/jcm12030805

The effect of six dried and UV-C-irradiated mushrooms powder on lipid oxidation and vitamin D contents of fish meat Reviewed

Influence of the Tibial Tunnel Angle and Posterior Tibial Slope on "Killer Turn" during Posterior Cruciate Ligament Reconstruction: A Three-Dimensional Finite Element Influence of the Tibial Tunnel Angle and Posterior Tibial Slope on "Killer Turn" during Posterior Cruciate Ligament Reconstruction: A Three-Dimensional Finite Element Analysis Reviewed

Fan Yang, Takuji Yokoe, Koki Ouchi, Takuya Tajima, Etsuo Chosa

Journal of Clinical Medicine 12 ( 3 ) 805 2023.1

Language：English Publishing type：Research paper (scientific journal)

Influence of the Tibial Tunnel Angle and Posterior Tibial Slope on "Killer Turn" during Posterior Cruciate Ligament Reconstruction: A Three-Dimensional Finite Element Analysis Reviewed

Fan Yang,Takuji Yokoe,Koki Ouchi,Takuya Tajima and Etsuo Chosa

Journal of Clinical Medicine 805 2023.1

Publishing type：Research paper (scientific journal) Publisher：Journal of Clinical Medicine

DOI： 10.3390/jcm12030805

Leg Muscle Activity and Joint Motion during Balance Exercise Using a Newly Developed Weight-Shifting-Based Robot Control System Reviewed

Go Yamako, Kirari Ito, Takanori Muraoka, Etsuo Chosa.

Int J Environ Res Public Health. 20 ( 2 ) 915 2023.1

Language：English Publishing type：Research paper (scientific journal)

Kido S., Chosa E., Tanaka R.

Food Chemistry 398 133917 2023.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Food Chemistry

The effect of dried and UV-C-irradiated mushroom powder on lipid oxidation and vitamin D content in fish meat was investigated. To this end, Flammulina velutipes, Grifola frondosa, Hypsizygus marmoreus, Lentinula edodes, Pleurotus eryngii, Pleurotus ostreatus were dried by hot air and irradiated by UV-C and evaluated the effect of these treatments on the components. In general, the ergothioneine content did not change substantially, the total phenolic compound content decreased by hot-air drying, and the ergocalciferol content increased by UV-C irradiation. To the evaluate effect of mushroom powder on lipid oxidation and vitamin D content in fish meat, 5% of the hot air dried and UV-C-irradiated mushroom powder was added to fish meat and oxidized. Consequently, all six mushrooms prevented lipid oxidation, and ergocalciferol content in each mushroom powder remained between 58.2% and 69.7%. Overall, P. eryngii, L. edodes, and P. ostreatus strongly prevented the generation of lipid peroxide and aldehyde.

DOI： 10.1016/j.foodchem.2022.133917

Leg Muscle Activity and Joint Motion during Balance Exercise Using a Newly Developed Weight-Shifting-Based Robot Control System

Yamako G., Ito K., Muraoka T., Chosa E.

International Journal of Environmental Research and Public Health 20 ( 2 ) 2023.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：International Journal of Environmental Research and Public Health

A novel and fun exercise robot (LOCOBOT) was developed to improve balance ability. This system can control a spherical robot on a floor by changing the center of pressure (COP) based on weight-shifting on a board. The present study evaluated leg muscle activity and joint motion during LOCOBOT exercise and compared the muscle activity with walking and sit-to-stand movement. This study included 10 healthy male adults (age: 23.0 ± 0.9 years) and examined basic LOCOBOT exercises (front–back, left–right, 8-turn, and bowling). Electromyography during each exercise recorded 13 right leg muscle activities. Muscle activity was represented as the percentage maximal voluntary isometric contraction (%MVIC). Additionally, the joint motion was simultaneously measured using an optical motion capture system. The mean %MVIC differed among LOCOBOT exercises, especially in ankle joint muscles. The ankle joint was primarily used for robot control. The mean %MVIC of the 8-turn exercise was equivalent to that of walking in the tibialis anterior, and the ankle plantar flexors were significantly higher than those in the sit-to-stand motion. Participants control the robot by ankle strategy. This robot exercise can efficiently train the ankle joint muscles, which would improve ankle joint stability.

DOI： 10.3390/ijerph20020915

Efficacy of Diagnosing Carpal Tunnel Syndrome Using the Median Nerve Stenosis Rate Measured on Ultrasonographic Sagittal Imagery: Clinical Case-Control Study. Reviewed

Toshiyuki Okura, Tomohisa Sekimoto, Tomomi Matsuoka, Hajime Fukuda, Hiroaki Hamada, Takuya Tajima, Etsuo Chosa.

Hand (NY) 18 ( 1_suppl ) 133S - 138S 2023.1

Language：English Publishing type：Research paper (scientific journal)

重心移動で操作するLOCOBOTを使用した理学療法が人工股関節全置換術後の立位体重負荷率改善に及ぼす効果

宮﨑茂明, 山子剛, 荒川英樹, 坂本武郎, 川口翼, 伊東きらり, 帖佐悦男

運動器理学療法学 3 ( Supplement ) P-15 - P-15 2023

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人日本運動器理学療法学会

DOI： 10.57281/jofmpt.3.p-15

Medical Support for Rugby Sevens in Tokyo2020+1 Olympic Games

Tajima Takuya, Chosa Etsuo, Nakamura Akihiko

Japanese Journal of Orthopaedic Sports Medicine 43 ( 3 ) 105 - 110 2023

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Orthopaedic Socety for Sports Medicine

DOI： 10.34473/jossm.43.3_105

Weight-shifting-based robot control system improves the weight-bearing rate and balance ability of the static standing position in hip osteoarthritis patients: a randomized controlled trial focusing on outcomes after total hip arthroplasty

Miyazaki S., Yamako G., Arakawa H., Sakamoto T., Kawaguchi T., Ito K., Chosa E.

PeerJ 11 e15397 2023

Language：English Publishing type：Research paper (scientific journal) Publisher：PeerJ

Background. After a total hip arthroplasty (THA), standing and walking balance are greatly affected in the early stages of recovery, so it is important to increase the weight-bearing amount (WBA) on the operated side. Sometimes, traditional treatments may not be enough to improve WBA and weight-bearing ratio (WBR) on the operated side in a satisfactory way. To solve this problem, we came up with a new weight-shifting-based robot control system called LOCOBOT. This system can control a spherical robot on a floor by changing the center of pressure (COP) on a force-sensing board in rehabilitation after THA. The goal of this study was to find out how rehabilitation with the LOCOBOT affects the WBR and balance in a static standing position in patients with unilateral hip osteoarthritis (OA) who had a primary uncemented THA. Methods. This randomized controlled trial included 20 patients diagnosed with Kellgren-Lawrence (K-L) grade 3 or 4 hip OA on the operative side and K-L grade 0 normal hip on the nonoperative side. We used the minimization method for allocation and randomly assigned patients to either the LOCOBOT group or the control group. As a result, 10 patient seach were randomly assigned to the LOCOBOT and control groups. Both groups received 40 min of rehabilitation treatment. Out of the 40 min, the LOCOBOT group underwent treatment for 10 min with LOCOBOT. The control group performed COP-controlled exercises on a flat floor instead of using LOCOBOT for 10 of the 40 min. All theoutcome measures were performed pre-THA and 11.9 ± 1.6 days after THA (12 days after THA). The primary outcome measure included WBR in the static standing position. Results. After12 days of THA, the LOCOBOT group exhibited significantly higher mean WBR and WBA (operated side) values than the control group. Furthermore, the LOCOBOT group exhibited significantly lower mean WBA (non-operated side) and outer diameter area (ODA) values than the control group. From pre-THA to 12 days after THA, the LOCOBOT group exhibited a significant improvement in mean WBR and WBA (operated side). Moreover, the mean WBA (non-operated side) and ODA significantly decreased. From pre-THA to 12 days after THA, the control group showed a significant increase in total trajectory length and ODA. Conclusions. The most important finding of this study was that patients were able to perform the LOCOBOT exercise as early as the second day after THA, and that WBR and ODA significantly improved by the 12th day after THA. This result demonstrated that the LOCOBOT effectively improves WBR in a short period of time after THA and is a valuable system for enhancing balance ability. This expedites the acquisition of independence in activities of daily living after THA and may contribute to optimizing the effectiveness of medical care.

DOI： 10.7717/PEERJ.15397

Ureter position and risk of ureteral injury during lateral lumbar interbody fusion

Hamanaka H., Tajima T., Kurogi S., Higa K., Nagai T., Kuroki T., Takamori H., Mukai S., Kamoto T., Chosa E.

Journal of Orthopaedic Science 2023

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

Background: Ureteral injury during lateral lumbar interbody fusion (LLIF) is uncommon. However, it is a serious complication that may require additional surgery should it occur. The objective of this study was to evaluate whether there was any change in the position of the left ureter between preoperative biphasic contrast-enhanced CT scanned in the supine position and intraoperative scanning in the right lateral decubitus position after stent placement, to assess the risk of ureteral injury in the actual surgical position. Methods: The position of the left ureter scanned with the O-arm navigation system with the patient in the right lateral decubitus position and its position on preoperative biphasic contrast-enhanced CT images scanned with the patient in the supine position were investigated comparing their positions at the L2/3, L3/4, and L4/5 levels. Results: The ureter was located along the interbody cage insertion trajectory in 25 of 44 disc levels (56.8%) in the supine position, but in only 4 (9.5%) in the lateral decubitus position. The proportion of patients in whom the left ureter was located lateral to the vertebral body (along the LLIF cage insertion trajectory) at each level was 80% in the supine position and 15.4% in the lateral decubitus position at the L2/3 level, 53.3% in the supine position and 6.7% in the lateral decubitus position at the L3/4 level, and 33.3% in the supine position and 6.7% in the lateral decubitus position at the L4/5 level. Conclusion: The proportion of patients in whom the left ureter was located on the lateral surface of the vertebral body when the patient was in the actual surgical position (lateral decubitus position) was 15.4% at the L2/3 level, 6.7% at the L3/4 level, and 6.7% at the L4/5 level, suggesting that caution is required during LLIF surgery.

DOI： 10.1016/j.jos.2023.04.011

Development of a video camera-type kayak motion capture system to measure water kayaking

Miyazaki S., Yamako G., Kimura R., Punchihewa N.G., Kawaguchi T., Arakawa H., Chosa E.

PeerJ 11 e15227 2023

Language：English Publishing type：Research paper (scientific journal) Publisher：PeerJ

Background: In kayaking, trunk motion is one of the important factors that prevent injury and improve performance. Kinematic studies in kayaking have been reported in laboratory settings using paddling simulators and ergometers. However, such studies do not reflect kayaking on water, the actual competitive environment. Therefore, we developed a video camera-type kayak motion capture system (KMCS) wherein action cameras were fixed to a kayak to capture images of markers attached to an athlete’s body. This study aimed to compare the kinematic data between KMCS and an optical motion capture system (OMCS) in kayaking and to determine the accuracy of the KMCS analysis. Methods: In a competition, five elite junior female kayak athletes performed kayak paddling under the unloaded condition using a kayak. The kayak was secured using a tri-folding bench and a towel, and twenty strokes were recorded during maximal paddling. One stroke was defined as the period from right catch to left catch, and the first six strokes were used to evaluate the accuracy. Trunk angles (tilting, turning, and rotation) were examined with the simultaneous use of KMCS and OMCS, and the differences between these systems were evaluated. To ensure reliability, intraclass correlation coefficient (ICC; a two-way mixed model for absolute agreement) was calculated for each angle. Furthermore, Bland–Altman analysis was performed to understand the agreement between the two systems. Results: Root mean square errors (RMSEs) were 1.42̊ and 3.94̊ for turning and rotation, respectively, and mean absolute errors (MAEs) were 1.08̊ and 3.00̊ for turning and rotation, respectively. The RMSE and MAE for tilting were 2.43̊ and 1.76̊, respectively, which indicated that the validity was comparable to that of other angles. However, the range of motion in tilting was lower than that in turning and rotation. Bland–Altman analysis showed good agreement in the total range of motion, with mean bias values of −0.84̊, −0.07̊, and −0.41̊ for tilting, turning, and rotation, respectively. The ICCs for tilting, turning, and rotation were 0.966, 0.985, and 0.973, respectively, and showed excellent reliability. Conclusions: The newly developed KMCS effectively measured the trunk motion with good accuracy in kayaking. In future studies, we intend to use KMCS to measure kayaking on water and collect data for performance improvement and injury prevention.

DOI： 10.7717/peerj.15227

Age- and sex-related differences in upper-body joint and endpoint kinematics during a drinking task in healthy adults.

Nakatake J, Arakawa H, Tajima T, Miyazaki S, Chosa E

PeerJ 11 e16571 2023

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.7717/peerj.16571

Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration Reviewed

Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility. Reviewed

Shinichiro Shirouzu, Naohiro Sugita, Narantsog Choijookhuu, Yu Yamaguma, Kanako Takeguchi, Takumi Ishizuka, Mio Tanaka, Fidya, Kengo Kai, Etsuo Chosa, Yoshihiro Yamashita, Chihiro Koshimoto, Yoshitaka Hishikawa.

Journal of Ovarian Research 15 ( 1 ) 133 2022.12

Language：English Publishing type：Research paper (scientific journal)

Investigation of cryotherapy for pain relief after arthroscopic shoulder surgery Reviewed

Rinko Uchida, Amy Hombu, Yasuyuki Ishida, Makoto Nagasawa, Etsuo Chosa

Journal of Orthopaedic Surgery and Research 17 ( 1 ) 553 2022.12

Language：English Publishing type：Research paper (scientific journal)

Yano K., Choijookhuu N., Ikenoue M., Fidya , Fukaya T., Sato K., Lee D., Taniguchi N., Chosa E., Nanashima A., Hishikawa Y.

Scientific Reports 12 ( 1 ) 11962 2022.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Scientific Reports

Liver regeneration is an extraordinarily complex process involving a variety of factors; however, the role of chromatin protein in hepatocyte proliferation is largely unknown. In this study, we investigated the functional role of high-mobility group box 2 (HMGB2), a chromatin protein in liver regeneration using wild-type and HMGB2-knockout (KO) mice. Liver tissues were sampled after 70% partial hepatectomy (PHx), and analyzed by immunohistochemistry, western blotting and flow cytometry using various markers of cell proliferation. In WT mice, hepatocyte proliferation was strongly correlated with the spatiotemporal expression of HMGB2; however, cell proliferation was significantly delayed in hepatocytes of HMGB2-KO mice. Quantitative PCR demonstrated that cyclin D1 and cyclin B1 mRNAs were significantly decreased in HMGB2-KO mice livers. Interestingly, hepatocyte size was significantly larger in HMGB2-KO mice at 36–72 h after PHx, and these results suggest that hepatocyte hypertrophy appeared in parallel with delayed cell proliferation. In vitro experiments demonstrated that cell proliferation was significantly decreased in HMGB2-KO cells. A significant delay in cell proliferation was also found in HMGB2-siRNA transfected cells. In summary, spatiotemporal expression of HMGB2 is important for regulation of hepatocyte proliferation and cell size during liver regeneration.

DOI： 10.1038/s41598-022-16258-4

Biomechanical effect of metal augment and bone graft on cup stability for acetabular reconstruction of total hip arthroplasty in hip dysplasia: a finite element analysis Reviewed

Wang Y., Wang M., Li C., Nakamura Y., Deng L., Yamako G., Chosa E., Pan C.

BMC Musculoskeletal Disorders 23 ( 1 ) 277 2022.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：BMC Musculoskeletal Disorders

Background: Different methods of acetabular reconstruction with total hip arthroplasty (THA) for Crowe II and III of adult developmental dysplasia of the hip (DDH) acetabular bone defect have been implemented clinically. However, the biomechanical effect of different augmented materials for acetabular reconstruction in THA on shell stability has never been discussed. Methods: In the present study, autologous bone graft (BG)and metal (Ti6Al4V) augment (MA) were simulated with several acetabular bone defect models of DDH in THA. The contact pressure and micromotion between the shell and host bone were measured for evaluating the shell stability using a finite element method. Results: The peak contact stress between shell and host bone was higher in the MA situation (12.45 vs 8.71 MPa). And the load transfer path was different, for BG models, the high local contact stresses were found at the junction of bone graft and host bone while for MA models the concentrated contact stresses were at the surface of MA. The peak relative micromotion between shell and host bone was higher in the MA situation (12.61 vs 11.13 µm). However, the peak micromotion decreased in the contact interface of MA and cup compared to the BG models. Conclusions: The higher micromotion was found in MA models, however, enough for bone ingrowth, and direct stronger fixation was achieved in the MA-cup interface. Thus, we recommended the MA can be used as an option, even for Crowe III, however, the decision should be made from clinical follow-up results.

DOI： 10.1186/s12891-022-05168-1

Does the contralateral healthy ankle of patient with ipsilateral mechanical lateral ankle laxity show greater lateral ankle laxity? Evaluation of the anterior talofibular ligament by stress ultrasonography Reviewed

Yokoe T., Tajima T., Kawagoe S., Yamaguchi N., Morita Y., Chosa E.

BMC Musculoskeletal Disorders 23 ( 1 ) 887 2022.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：BMC Musculoskeletal Disorders

Background: A number of studies have evaluated risk factors for lateral ankle sprain (LAS) or chronic lateral ankle instability (CLAI). However, the definitive risk factors for LAS or CLAI remain controversial. The purpose of this study was to evaluate whether the contralateral healthy ankles of subjects with ipsilateral mechanical lateral ankle laxity (group I) show greater lateral ankle laxity in comparison to the healthy ankles of bilateral healthy controls (group B). Methods: From March 2020, anterior talofibular ligament (ATFL) lengths of young adult volunteers were cross-sectionally measured in non-stress and stress positions using a previously reported stress ultrasonography (US) procedure. The ATFL ratio (the ratio of stress ATFL/non-stress ATFL length) was calculated as an indicator of lateral ankle laxity. The manual anterior drawer test (ADT) was also performed. The US findings of healthy ankles from groups I and B were compared. Results: A total of 154 subjects in group B (mean age, 24.5 ± 2.8 years; male/female, 84/70) and 40 subjects in group I (mean age, 24.4 ± 2.3 years; male/female, 26/14) were included in the study. There was no significant difference in the ADT between the groups. There were no significant differences in the non-stress ATFL length (19.4 ± 1.8 vs. 19.3 ± 1.9, p = 0.84), stress ATFL length (20.8 ± 1.8 vs. 20.9 ± 1.9, p = 0.66), length change (1.5 ± 0.6 vs. 1.6 ± 0.6, p = 0.12) and ATFL ratio (1.08 ± 0.03 vs. 1.08 ± 0.03, p = 0.13) between the groups. Conclusion: No significant difference was detected between the contralateral healthy ankles of subjects with ipsilateral mechanical lateral ankle laxity and those of bilateral healthy controls.

DOI： 10.1186/s12891-022-05838-0

Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility

Shirouzu S., Sugita N., Choijookhuu N., Yamaguma Y., Takeguchi K., Ishizuka T., Tanaka M., Fidya F., Kai K., Chosa E., Yamashita Y., Koshimoto C., Hishikawa Y.

Journal of Ovarian Research 15 ( 1 ) 133 2022.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Ovarian Research

Background: High-Mobility Group Box 1 (HMGB1) and HMGB2 are chromatin-associated proteins that belong to the HMG protein family, and are involved in the regulation of DNA transcription during cell differentiation, proliferation and regeneration in various tissues. However, the role of HMGB2 in ovarian folliculogenesis is largely unknown. Methods: We investigated the functional role of HMGB1 and HMGB2 in ovarian folliculogenesis and fertilization using C57BL/6 wild type (WT) and HMGB2-knockout (KO) mice. Ovarian tissues were obtained from WT and HMGB2-KO mice at postnatal days 0, 3, 7, and 2, 6 months of age, then performed immunohistochemistry, qPCR and Western blotting analyses. Oocyte fertilization capability was examined by natural breeding and in vitro fertilization experiments. Results: In HMGB2-KO mice, ovary weight was decreased due to reduced numbers of oocytes and follicles. Natural breeding and in vitro fertilization results indicated that HMGB2-KO mice are subfertile, but not sterile. Immunohistochemistry showed that oocytes expressed HMGB2, but not HMGB1, in neonatal and adult WT ovaries. Interestingly, in HMGB2-KO ovaries, a compensatory increase in HMGB1 was found in oocyte nuclei of neonatal and 2-month-old mice; however, this was lost at 6 months of age. Conclusions: The depletion of HMGB2 led to alterations in ovarian morphology and function, suggesting that HMGB2 plays an essential role in ovarian development, folliculogenesis and fertilization.

DOI： 10.1186/s13048-022-01071-4

Investigation of cryotherapy for pain relief after arthroscopic shoulder surgery

Uchida R., Hombu A., Ishida Y., Nagasawa M., Chosa E.

Journal of Orthopaedic Surgery and Research 17 ( 1 ) 553 2022.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Surgery and Research

Background: Recently, cryotherapy has become a common practice for postoperative pain management. The current accepted practice in Japan is the use of cryotherapy at 5 °C after arthroscopic shoulder surgery. However, this therapy has been reported to be highly intense because the sustained low temperature causes discomfort for patients. The optimum temperature and duration of cooling required for comfortable and effective cryotherapy after arthroscopic shoulder surgery were investigated. Methods: Because pain levels might differ depending on the condition, we selected 52 patients with rotator cuff injuries, which were the most common disorders indicated for arthroscopic shoulder surgery. Patients were treated with cryotherapy at 5 °C or 10 °C for 16 h or 24 h. The pain level was determined using the visual analogue scale, and deep shoulder joint temperatures were recorded at different time points for analysis. Results: Pain after arthroscopic shoulder surgery was found to be related to the presence of a brachial plexus block using the interscalene approach during surgical anesthesia. To obtain effective analgesia with cryotherapy, the cooling temperature and duration of cryotherapy had to be changed based on the presence or absence of the brachial plexus block. Patients who received brachial plexus blocks had the lowest recorded pain scores after receiving cryotherapy at 5 °C for 24 h after surgery. Patients who did not receive the block had the lowest recorded pain scores when receiving cryotherapy at either 5 °C for 16 h or 10 °C for 24 h. Conclusions: Using universal cryotherapy intensity and duration settings regardless of the use of other interventions is likely to unintentionally increase postoperative pain levels. This study revealed that cryotherapy at 5 °C for 24 h was optimal for patients who received an anesthesia block and at 5 °C for 16 h or at 10 °C for 24 h for those who did not receive the anesthesia block. These results can be used as a reference for setting the temperature and duration of cryotherapy after arthroscopic shoulder surgery.

DOI： 10.1186/s13018-022-03404-x

特集腱板断裂治療のエキスパートを目指そう鏡視下腱板修復術:腱板断裂は何で縫うか Reviewed

長澤誠, 帖佐悦男

関節外科　基礎と臨床 41 ( 11 ) 1220 - 1228 2022.11

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000001198

特集腱板断裂治療のエキスパートを目指そう introduction Reviewed

帖佐悦男

関節外科　基礎と臨床 41 ( 11 ) 1157 - 1157 2022.11

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000001190

The Results of Orthopaedic Medical Examinations in Adolescent Amateur Weightlifters. Reviewed

Yokoe T, Tajima T, Yamaguchi N, Nagasawa M, Morita Y, Chosa E

International journal of environmental research and public health 19 ( 21 ) 2022.10

Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Environmental Research and Public Health

Few studies have reported injuries and physical characteristics in adolescent weightlifters. The purpose of this study was to report the results of orthopaedic medical examinations in adolescent amateur weightlifters that were performed cross-sectionally from 2012 to 2019. The orthopaedic medical examination included physical examinations, generalized joint laxity, muscle and joint tightness, static alignment, muscle volume of the lower extremities, and medial longitudinal arch of the foot (the height from the tip of the navicular tubercle to the ground surface). A questionnaire survey regarding pain in the spine and lower extremities was also performed. A total of 99 adolescent weightlifters were included (male/female, 71/28; mean age, 16.2 ± 0.2 years). A total of 9.1% had received orthopaedic treatments, with spine injuries being the most prevalent. Of those who had not received orthopaedic treatments, 31.1% had pain in the spine or lower extremities (for >4 weeks). There were no significant gender differences in the incidence of pain or positive findings of physical examinations. Female weightlifters had a more reduced dorsiflexion of the ankle joint than male weightlifters (p = 0.02). Male weightlifters had a lower flexibility of the quadriceps than female weightlifters. The results of orthopaedic medical examinations in this study may help clinicians and young weightlifters to prevent injuries in competitive weightlifting.

DOI： 10.3390/ijerph192113947

Fixation of an Osteochondral Lesion of the Femoral Intercondylar Groove Using Autogenous Osteochondral Grafts and Bioabsorbable Pins in a Patient with Open Physes: A Case Report. Reviewed

Yokoe T, Tajima T, Yamaguchi N, Morita Y, Chosa E

Medicina (Kaunas, Lithuania) 58 ( 11 ) 2022.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Medicina (Lithuania)

Osteochondral lesion (OCL) of the patellofemoral (PF) joint is not an uncommon cause of knee pain, and surgery is needed when conservative treatment fails. However, there is a lack of evidence regarding the optimal surgical treatment for OCL of the PF joint. Fixation of OCLs using autogenous osteochondral grafts has been reported to be effective for OCL of the knee. However, in this surgical technique, the biomechanical strength of osteochondral grafts may not be sufficient in patients with open physes due to the specific quality of the cartilage and subchondral bone given their age. There is a lack of studies reporting fixation of the OCL located in the PF joint using autogenous osteochondral grafts. We herein report a case of OCL of the femoral intercondylar groove where autogenous osteochondral grafts augmented with bioabsorbable pins were used to fix the lesion in a 14-year-old patient with open physes. Preoperative MRI revealed a completely detached OCL of the intercondylar groove (36 mm × 20 mm). Although a total of four osteochondral grafts were harvested from the non-weightbearing area of the lateral femoral condyle, cartilage detached from one of the grafts. The quality of the osteochondral grafts was considered to be insufficient for stabilization of the OCL; thus, two bioabsorbable pins were additionally inserted following fixation of the lesion using three osteochondral grafts. After two years of follow-up, postoperative functional scores were favorable without knee pain. The present case suggests that fixation of the OCL using autogenous osteochondral grafts may not be appropriate for young patients with open physes.

DOI： 10.3390/medicina58111528

HMM-Based Action Recognition System for Elderly Healthcare by Colorizing Depth Map Reviewed

Htet Y., Zin T.T., Tin P., Tamura H., Kondo K., Chosa E.

International Journal of Environmental Research and Public Health 19 ( 19 ) 2022.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：International Journal of Environmental Research and Public Health

Addressing the problems facing the elderly, whether living independently or in managed care facilities, is considered one of the most important applications for action recognition research. However, existing systems are not ready for automation, or for effective use in continuous operation. Therefore, we have developed theoretical and practical foundations for a new real-time action recognition system. This system is based on Hidden Markov Model (HMM) along with colorizing depth maps. The use of depth cameras provides privacy protection. Colorizing depth images in the hue color space enables compressing and visualizing depth data, and detecting persons. The specific detector used for person detection is You Look Only Once (YOLOv5). Appearance and motion features are extracted from depth map sequences and are represented with a Histogram of Oriented Gradients (HOG). These HOG feature vectors are transformed as the observation sequences and then fed into the HMM. Finally, the Viterbi Algorithm is applied to recognize the sequential actions. This system has been tested on real-world data featuring three participants in a care center. We tried out three combinations of HMM with classification algorithms and found that a fusion with Support Vector Machine (SVM) had the best average results, achieving an accuracy rate (84.04%).

DOI： 10.3390/ijerph191912055

頚椎前方固定術後の食道損傷2例 Reviewed

河野翔, 黒木智文, 李徳哲, 永井琢哉, 比嘉聖, 黒木修司, 濱中秀昭, 帖佐悦男

整形外科と災害外科 71 ( 3 ) 333 - 338 2022.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【はじめに】頸椎前方固定術の合併症である食道損傷の発生率は0.1～0.45%と報告されている．今回，我々は頸椎前方固定術後に発症した食道損傷の2例を経験したので文献的考察を加えて報告する．【症例1】41歳女性，頸椎椎間板ヘルニアの診断で頸椎前方除圧固定術を施行中にエアードリルが食道に接触した．術後に創部膿瘍から口腔内常在菌を検出し，嚥下造影検査にて食道損傷と診断した．保存的加療により術後56日で食事摂取が可能となった．【症例2】54歳女性，頸椎骨肉腫の診断で頸椎前方固定術及び術後放射線治療を施行された．術15年後に感染を伴う食道瘻のためプレート抜去されたが椎体の骨溶解像を認め，生検で口腔内常在菌が検出された．保存的加療によりプレート抜去後1年3ヶ月で食事摂取可能となった．【考察】頸椎前方固定術後の食道損傷は発症時期や穿孔部の大きさで治療が異なる．本症例では診断に嚥下造影検査が有用であった．長期絶食期間を要した．

DOI： 10.5035/nishiseisai.71.333

びまん性特発性骨増殖症に伴う腰椎骨折に対しDouble endplates penetrating screw（DEPS）法にて後方固定術を施行した一例 Reviewed

黒木啓吾, 黒木智文, 永井琢哉, 比嘉聖, 黒木修司, 濱中秀昭, 帖佐悦男

整形外科と災害外科 71 ( 3 ) 352 - 354 2022.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

要旨：びまん性特発性骨増殖症（以下DISH）に伴う椎体骨折は不安定性が強く，手術が必要な場合が多い．今回Double endplates penetrating screw（以下DEPS法）と5.5mmのチタンロッドを用いた後方固定で良好な成績を得たので報告する．症例は83歳男性，1週前に転倒し，疼痛のため体動困難となり，紹介入院となった．DISHに伴う第2腰椎骨折と診断し，手術を施行した．腹臥位で可及的に後弯を保持し，O-armナビ下に経皮的に3above-3belowのDEPSを刺入，5.5mmのチタンロッドで締結した．術直後は第2腰椎の終板角が20度と開大していたが，術後7ヶ月で7度と減弱し，スクリューの緩みはなく，骨癒合が得られた．DISHに伴う骨折には強固な固定力のあるDEPS法と術後のしなりによる整復を利用した5.5mmチタンロッドによる経皮的後方固定が有用と考える．

DOI： 10.5035/nishiseisai.71.352

股関節鏡での摘出術後にSurgical dislocationを用いて摘出を行った股関節滑膜性骨軟骨腫症の一例 Reviewed

山元楓子, 日吉優, 今里浩之, 平川雄介, 山口洋一朗, 中村嘉宏, 舩元太郎, 坂本武郎, 帖佐悦男

整形外科と災害外科 71 ( 4 ) 744 - 746 2022.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【はじめに】股関節滑膜性骨軟骨腫症の治療では鏡視下手術か外科的脱臼操作を伴う直視下手術が選択される．股関節鏡での摘出術後にSurgical dislocationを用いて再摘出を行った1例を報告する．【症例】38歳男性．10年前に誘因なく右股関節痛と可動域制限が出現．滑膜性骨軟骨腫症の診断で鏡視下に滑膜・遊離体を摘出した．疼痛改善したが一部残存を認め，再発に伴い疼痛増強しSurgical dislocationを用いて摘出した．術後再発なく経過している．【考察】鏡視下手術は低侵襲だが，体格や病変の位置により鏡視困難な場合，病変の残存・再発の可能性がある．Surgical dislocationを用いた直視下手術では寛骨臼への視野確保が可能だが，大腿骨頭壊死の危険性が指摘される．当院では側方アプローチでSurgical dislocationを行っており，大転子の骨切り量は少なく低侵襲で大腿骨頭壊死の危険性も低いという利点がある．本症例のように鏡視困難な位置に病変がある場合，Surgical dislocationを用いた手術は有用と考える．

DOI： 10.5035/nishiseisai.71.744

診断に時間を要したIliosacral screw挿入に伴う上殿動脈仮性動脈瘤の1例 Reviewed

森田恭史, 今里浩之, 日吉優, 山元楓子, 平川雄介, 山口洋一朗, 舩元太郎, 中村嘉宏, 坂本武郎, 帖佐悦男

整形外科と災害外科 71 ( 4 ) 842 - 844 2022.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【はじめに】Iliosacral screw（IS screw）挿入に伴う上殿動脈損傷は注意すべき合併症であり，術後に貧血の進行などを契機に早期発見される事が多い．今回診断に時間を要した上殿動脈仮性動脈瘤を経験したため報告する．【症例】68歳男性，40 m滑落し受傷．AO分類61B2. 1，Lateral compression 1の骨盤輪骨折と診断しIS screwによる骨接合術を施行した．術後9ヶ月で発熱と左臀部の著明な腫脹を認め当院救急搬送．造影CT検査で上殿動脈の仮性動脈瘤を認めた．動脈塞栓術，血腫除去術を施行し術後1年で再発を認めていない．【考察】IS screw挿入に伴う上殿動脈損傷は考慮しなければならない合併症である．本症例は貧血進行が緩徐であった事，単純CTのみで評価をした事が発見の遅れに繋がった．綿密な術前計画を立てること，上殿動脈損傷の可能性を考慮し合併症を見逃さない事が重要である．

DOI： 10.5035/nishiseisai.71.842

足部びまん性色素性絨毛結節性滑膜炎に対し，関節鏡下腫瘍切除術を施行した一例 Reviewed

外山宗樹, 横江琢示, 田島卓也, 山口奈美, 大田智美, 長澤誠, 森田雄大, 川越秀一, 帖佐悦男

整形外科と災害外科 71 ( 4 ) 725 - 729 2022.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【背景】色素性絨毛結節性滑膜炎（Pigmented villonodular Synovitis, PVS）は関節滑膜や腱鞘に発生する比較的稀な良性腫瘍である．多くは膝関節周囲に発生し，足関節発生症例は稀である．今回，足部びまん性PVSに対して関節鏡下腫瘍切除術を行い，良好な短期成績を得た一例を経験したので報告する．【症例】23歳女性．数年前から左足部外側に腫瘤を自覚していたが，放置していた．しかしながら，腫瘤の消退を認めず前医を受診し，PVSの疑いで当科紹介となった．当科では関節鏡下腫瘍切除術を施行した．足関節前方および後足部鏡視下併用で足関節，足関節周囲，距骨下に病変を認め，関節鏡視下に腫瘍を切除した．術後病理診断ではびまん性PVSの診断であった．術後26ヶ月経過し，再発なく経過している．【結語】足部びまん性PVSに対し，足関節前方および後足部鏡視下併用での関節鏡下腫瘍切除術を施行し，良好な短期成績を得た一例を経験した．

DOI： 10.5035/nishiseisai.71.725

転位の大きい上前腸骨棘裂離骨折に対してSuture anchorを用いて固定した3例 Reviewed

高橋巧, 帖佐悦男, 栗原典近, 小薗敬洋, 川野啓介, 石原和明, 木戸義隆

整形外科と災害外科 71 ( 4 ) 625 - 627 2022.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【目的】転位の大きい（15 mm以上）上前腸骨棘裂離骨折の治療方針に一定の見解は得られていない．今回Suture anchorを使用して骨接合術を施行した3例を経験したため報告する．【症例】（1）14歳男児．骨片は17 mm下方に転位．（2）13歳男児．骨片は19 mm下方に転位．（3）13歳男児．骨片は15mm下方に転位．受傷起点は全例ダッシュ時であった．いずれも転位が15 mm以上と大きく，手術加療を選択した．手術は骨片を整復しSuture anchorを1～2本使用し，骨片・骨腱移行部に縫合固定した．【結果】全例8週程度で骨癒合を認め，術後8～9週で部活動復帰が可能であった．1例外側大腿皮神経領域の知覚低下を認めた．【考察】上前腸骨棘裂離骨折の手術加療は，スクリュー固定が多く報告されている．しかし抜釘が必要なことや骨片が小さい時に固定困難である．Suture anchorでの固定は，スクリュー固定と比較して骨癒合，スポーツ復帰期間に遜色なく，有用である可能性がある．

DOI： 10.5035/nishiseisai.71.625

Head Injury Assessment in the Elite Level Rugby Union in Japan: Review of 3 Seasons Reviewed

Tajima T., Ota O., Nagayama M., Takahashi M., Yamada M., Ishiyama N., Yoshida I., Takemura M., Hara K., Akama T., Mitsumori N., Higashihara J., Toyama Y., Furuya M., Chosa E., Nakamura A.

International Journal of Sports Medicine 43 ( 10 ) 889 - 894 2022.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：International Journal of Sports Medicine

Head Injury Assessment (HIA) is the screening tool for head injury during a rugby game. The purpose of this study was to investigate the epidemiology of HIA in the Japan Rugby Top League (JRTL). The incidences of HIA, defined concussion (per 1,000 player-hours) and repeated concussions were evaluated in three seasons (2016-17, 2017-18, 2018-19; total 360 games). The HIA incidence rates were 12.7 (95% confidence interval 9.5-15.9), 20.8 (16.8-24.9), and 25.0 (20.5-29.5) in each season. HIA-1 criteria 2, which is applied for suspected concussion cases, was performed for 46 cases in the 2016-17 season, 81 cases in the 2017-18 season, and 88 cases in the 2018-19 season. The concussion incidence rates were significantly greater in the 2017-18 season (9.6/1000 player-hours, 95% confidence interval 6.8-12.4) and the 2018-19 season (14.4, 11-17.8) compared to the 2016-17 season (4.8, 2.8-6.8). The number of repeated concussion cases in the same season was 1 in the 2016-17 season and 4 in both the 2017-18 and 2018-19 seasons. This study confirmed significantly higher HIA and concussion incidence rates over time. Although the HIA system might have been established in the three seasons in JRTL, comprehensive management needs to be improved to prevent repeated concussions.

DOI： 10.1055/a-1810-6509

宮崎県の高校ラグビーにおけるメディカルサポート－３年間の外傷調査－ Reviewed

森田恭史,今里浩之,岩佐一真,横江琢示,森田雄大,比嘉聖,山口奈美,中村嘉宏,田島卓也,帖佐悦男,吉川大輔

九州・山口スポーツ医・科学研究会誌 33 37 - 40 2022.7

Language：Japanese Publishing type：Research paper (conference, symposium, etc.) Publisher：九州・山口スポーツ医・科学研究会

我々は宮崎県で開催されるラグビーの公式戦で要請のあった全試合にマッチデイドクター配備および後方支援病院を整備している．今回，15人制高校ラグビー宮崎県大会の外傷調査を行ったため報告する．

サーファー外来はじめました Reviewed

小島岳史,柏木輝行,岩佐一真,吉田尚紀,帖佐悦男

九州・山口スポーツ医・科学研究会誌 33 1 - 5 2022.7

Language：Japanese Publishing type：Research paper (conference, symposium, etc.) Publisher：九州・山口スポーツ医・科学研究会

女ともに日本人がメダルを取り，競技スポーツとしてようやく認知された．しかしまだメディカルサポートが充実しているとは言い難い．今回サーファー外来を訪れた症例についてまとめた．対象は2018年４月から2021年８月までに受診したサーファー36名43例．平均年齢は44.1歳，外傷が６例であった．手術を５例におこなった．サーフィンを長く続けることによって障害発生のリスクが増加すると報告されており，今回の調査でも年齢，サーフィン歴ともに他スポーツより高い傾向であった．

サーフィン競技会における医療体制の向上と重症事故発生予防を目的とした安全評価法の作成 Reviewed

石田翔太郎,小島岳史,帖佐悦男,田島卓也

九州・山口スポーツ医・科学研究会誌 33 6 - 11 2022.7

Language：Japanese Publishing type：Research paper (conference, symposium, etc.) Publisher：九州・山口スポーツ医・科学研究会

サーフィンは海上競技であり，陸上競技では助かる脳震盪でさえも死亡事故につながってしまう．そのため安全に競技会を開催するためにはドクター派遣だけではなくライフセーバー，救急車や後方支援病院との連携，AEDの設置が必要となる．しかし現在このような安全対策ができている競技会は少ない．今回安全度向上を目的としてサーフィン競技会専用の宮崎式安全評価法を作成した．

増大特集加齢とリハビリテーション第3部　加齢によって生じた課題への対応 2.骨粗鬆症と骨折 Reviewed

帖佐悦男

総合リハビリテーション 50 ( 6 ) 673 - 681 2022.6

Publishing type：Research paper (scientific journal) Publisher：株式会社医学書院

DOI： 10.11477/mf.1552202532

A longer duration from injury to surgery is associated with preoperative deterioration of an isolated meniscal tear in patients aged 40 years or older Reviewed

Elective one-stage all four-ligament reconstruction after open knee dislocation: A case report Reviewed

Takuji Yokoe, Takuya Tajima, Nami Yamaguchi, Etsuo Chosa

Journal of Orthopaedic Science 27 ( 3 ) 743 - 749 2022.5

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jos.2019.08.012

Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.

Journal of Orthopaedic Surgery 30 ( 2 ) 10225536221101692 2022.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Surgery

Purpose: To evaluate the preoperative deterioration of an isolated meniscal tear in patients aged 40 years or older, and whether time from injury to surgery is associated with worsening of a meniscal tear. Methods: Patients aged 40 years or older who underwent arthroscopic surgery for isolated meniscal tear between 2014 and 2019 were retrospectively reviewed. The diagnostic magnetic resonance imaging (MRI) findings and arthroscopic findings were compared to evaluate the deterioration of meniscal tears. Predictors of the development of meniscal tears; patient demographic factors, duration from injury to surgery (injury to MRI and MRI to surgery), and image findings were assessed. Results: A total of 58 patients (58 knees) were included (mean age, 55.9 ± 8.5 years; male/female, 31/27). An isolated meniscal tear deteriorated in 28 (48.3%). Compared patients with and without deteriorated meniscal tear, significant differences were found in the MRI grade of meniscal tear (p = 0.03), duration from injury to MRI (164.2 ± 167.9 vs 45.2 ± 48.7 days, p < 0.001), and from MRI to surgery (148.8 ± 91.1 vs 67.6 ± 56.7 days, p < 0.001). A multivariate regression analysis showed that the duration from injury to MRI (odds ratio [OR], 1.03; p < 0.001) and from MRI to surgery (OR, 1.02; p < 0.001) were independent predictors. Conclusion: Approximately 50% of isolated meniscal tears deteriorated preoperatively in patients aged 40 years or older. The duration from injury to surgery was an independent predictor of worsening of an isolated meniscal tear.

DOI： 10.1177/10225536221101692

Angiotensin II Induces Aortic Rupture and Dissection in Osteoprotegerin-Deficient Mice Reviewed

The impact of helicopter emergency medical services and craniocervical traction on the early reduction of cervical spine dislocation in a rural area of Japan Reviewed

Deokcheol Lee, Keisuke Kawano, Shotaro Ishida, Yoichiro Yamaguchi, Tomofumi Kuroki, Takuya Nagai, Kiyoshi Higa, Syuji Kurogi, Hideaki Hamanaka, Hidenobu Ochiai, Etsuo Chosa

Journal of Orthopaedic Science 27 ( 3 ) 606 - 613 2022.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jos.2021.03.008

Tsuruda T., Yamashita A., Otsu M., Koide M., Nakamichi Y., Sekita-Hatakeyama Y., Hatakeyama K., Funamoto T., Chosa E., Asada Y., Udagawa N., Kato J., Kitamura K.

Journal of the American Heart Association 11 ( 8 ) e025336 2022.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of the American Heart Association

BACKGROUND: The biological mechanism of action for osteoprotegerin, a soluble decoy receptor for the receptor activator of nuclear factor-kappa B ligand in the vascular structure, has not been elucidated. The study aim was to determine if osteopro-tegerin affects aortic structural integrity in angiotensin II (Ang II)-induced hypertension. METHODS AND RESULTS: Mortality was higher (P<0.0001 by log-rank test) in 8-week-old male homozygotes of osteoprotegerin gene-knockout mice given subcutaneous administration of Ang II for 28 days, with an incidence of 21% fatal aortic rupture and 23% aortic dissection, than in age-matched wild-type mice. Ang II-infused aorta of wild-type mice showed that osteo-protegerin immunoreactivity was present with proteoglycan. The absence of osteoprotegerin was associated with decreased medial and adventitial thickness and increased numbers of elastin breaks as well as with increased periostin expression and soluble receptor activator of nuclear factor-kappa B ligand concentrations. PEGylated human recombinant osteoprotegerin administration decreased all-cause mortality (P<0.001 by log-rank test), the incidence of fatal aortic rupture (P=0.08), and aortic dissection (P<0.001) with decreasing numbers of elastin breaks, periostin expressions, and soluble receptor activator of nuclear factor-kappa B ligand concentrations in Ang II-infused osteoprotegerin gene-knockout mice. CONCLUSIONS: These data suggest that osteoprotegerin protects against aortic rupture and dissection in Ang II-induced hypertension by inhibiting receptor activator of nuclear factor-kappa B ligand activity and periostin expression.

DOI： 10.1161/JAHA.122.025336

Association between the Beighton Score and Stress Ultrasonographic Findings of the Anterior Talofibular Ligament in Healthy Young Women: A Cross-Sectional Study Reviewed

Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.

Journal of Clinical Medicine 11 ( 7 ) 2022.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Clinical Medicine

The Beighton score (BS) is widely used to evaluate generalized joint laxity. However, the association between the BS and lateral ankle laxity is unclear. This study compared the ultrasono-graphic (US) findings of the anterior talofibular ligament (ATFL) between high-(≥6) and low-(≤3) BS groups of healthy young women. The ATFL lengths of healthy young women were measured in the stress and nonstress positions using the previously reported technique from March 2021 to January 2022. The ATFL ratio (ratio of stress to nonstress ATFL length) was used as an indicator of lateral ankle laxity. The anterior drawer test (ADT) was performed. The correlation between the BS and US findings was also examined. A total of 20 (high-BS group) and 61 (low-BS group) subjects with a mean age of 23.8 ± 1.0 years were included. The high-BS group showed a higher grade of ADT than the low-BS group. No significant differences were found in the nonstress and stress ATFL lengths and ATFL ratio (1.10 ± 0.05 vs. 1.09 ± 0.05, p = 0.19) between the groups. No correlation was found between the BS and US findings. In conclusion, this study did not detect significant differences in the US findings of the ATFL between the high-and low-BS groups.

DOI： 10.3390/jcm11071759

Symptomatic discoid lateral meniscus shows a relationship between types and tear patterns, and between causes of clinical symptom onset and the age distribution Reviewed

Nami Yamaguchi, Etsuo Chosa, Takuya Tajima, Yudai Morita, Takuji Yokoe

Knee Surg Sports Traumatol Arthrosc 30 ( 4 ) 1436 - 1442 2022.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00167-021-06635-3

学会を聞く第36回日本整形外科学会基礎学術集会

帖佐悦男

整形外科 73 ( 3 ) 283 - 287 2022.3

Publishing type：Research paper (scientific journal) Publisher：南江堂

DOI： 10.15106/j_seikei73_283

Crucial role of high-mobility group box 2 in mouse ovarian follicular development through estrogen receptor beta

Yamaguma Y., Sugita N., Choijookhuu N., Yano K., Lee D., Ikenoue M., Fidya , Shirouzu S., Ishizuka T., Tanaka M., Yamashita Y., Chosa E., Taniguchi N., Hishikawa Y.

Histochemistry and Cell Biology 157 ( 3 ) 359 - 369 2022.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Histochemistry and Cell Biology

High-mobility group box 2 (HMGB2) is a chromatin-associated protein that is an important regulator of gene transcription, recombination, and repair processes. The functional importance of HMGB2 has been reported in various organs, including the testis, heart, and cartilage. However, its role in the ovary is largely unknown. In this study, ovary tissues from wild-type (WT) and HMGB2-knock-out (KO) mice were examined by histopathological staining and immunohistochemistry. The ovary size and weight were significantly lower in HMGB2-KO mice than in age-matched WT littermates. Histopathological analysis revealed ovarian atrophy and progressive fibrosis in 10-month-old HMGB2-KO mouse ovaries. Compared to age-matched WT mice, the numbers of oocytes and developing follicles were significantly decreased at 2 months of age and were completely depleted at 10 months of age in HMGB2-KO mice. Immunohistochemistry revealed the expression of HMGB2 in the granulosa cells of developing follicles, oocytes, some corpora lutea, and stromal cells. Importantly, HMGB2-positive cells were co-localized with estrogen receptor beta (ERβ), but not ERα. Estrogen response element-binding activity was demonstrated by southwestern histochemistry, and it was decreased in HMGB2-KO mouse ovaries. Cell proliferation activity was also decreased in HMGB2-KO mouse ovaries in parallel with the decreased folliculogenesis. These results indicated that the depletion of HMGB2 induced ovarian atrophy that was characterized by a decreased ovarian size and weight, progressive fibrosis, as well as decreased oocytes and folliculogenesis. In conclusion, we demonstrated the crucial role of HMGB2 in mouse ovarian folliculogenesis through ERβ expression.

DOI： 10.1007/s00418-022-02074-4

Role of Mel1/Prdm16 in bone differentiation and morphology

原発性骨粗鬆症に対するロモソズマブの実臨床成績の検討 Reviewed

小牧亘, 深野木快士, 太田尾佑史, 福富雅子, 前原孝政, 内村裕起, 大久保節子, 植村貞仁, 帖佐悦男

日本骨粗鬆症学会雑誌 8 ( 1 ) 31 - 43 2022.2

Language：Japanese Publishing type：Research paper (scientific journal)

Kaneda-Nakashima K., Igawa K., Suwanruengsri M., Naoyuki F., Ichikawa T., Funamoto T., Kurogi S., Sekimoto T., Yamashita Y., Chosa E., Yamaguchi R., Morishita K.

Experimental Cell Research 410 ( 2 ) 112969 2022.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Experimental Cell Research

MEL1 (MDS1/EVI1-like gene 1/PRDM16), a zinc finger protein, is located near the chromosomal breakpoint at 1p36 in human acute myeloid leukemia (AML) cells with the t (1; 3) (p36; q21) translocation. Mel1/Prdm16 is not only a causative gene of leukemia, but also has multiple regulatory functions, such as the regulation of fat metabolism. To investigate the function of Mel1/Prdm16, we generated Mel1/Prdm16-deficient mice, but homozygous deficiency (Mel1/Prdm16−/−) was embryonic lethal at E 11.5. Heterozygous mice showed abnormal cartilage and bone formation in the postnatal skull and long bones, suggesting that Mel1/Prdm16 expression plays an important role in bone development. In osteoblast and chondrocyte cell lines, Mel1/Prdm16 promotes the differentiation of chondrocytes and regulates the differentiation of osteoblasts. Transient repression of the master regulator Runx2 is required for chondrocyte differentiation at an early stage of differentiation. However, in Mel1/Prdm16-suppressed ATDC5 cells, the initial suppression of Runx2 was lacking and its expression was upregulated at the beginning of differentiation, suggesting that chondrogenic differentiation is suppressed in Mel1/Prdm16+/− mesenchymal progenitor cells because Runx2 expression is upregulated during the early stage of differentiation. Thus, the Mel1/Prdm16 gene may be involved in the early repression of Runx2 expression during osteochondral differentiation and promote chondrogenic differentiation.

DOI： 10.1016/j.yexcr.2021.112969

Action Recognition System for Senior Citizens Using Depth Image Colorization

Htet Y., Zin T.T., Tamura H., Kondo K., Chosa E.

LifeTech 2022 - 2022 IEEE 4th Global Conference on Life Sciences and Technologies 494 - 495 2022

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：LifeTech 2022 - 2022 IEEE 4th Global Conference on Life Sciences and Technologies

This paper describes about the system which can be used at the care center for the purpose of elderly action recognition using depth camera. The depth image colorization is used for compression, visualization, and person detection process. The YOLOv5 (You Only Look Once) algorithm is used as object detector. The space-time features are extracted from depth sequences and they are recognized by linear SVM (Support Vector Machine) classifier. The random image sequences are generated for testing to recognize six actions. The results show that this system can detect the various actions with the average of 92% accuracy for different durations.

DOI： 10.1109/LifeTech53646.2022.9754900

EPLINβ Is Involved in the Assembly of Cadherin-catenin Complexes in Osteoblasts and Affects Bone Formation

Miyazaki Shihoko, Funamoto Taro, Sekimoto Tomohisa, Kurogi Syuji, Ohta Tomomi, Nagai Takuya, Tajima Takuya, Imasaka Mai, Yoshinobu Kumiko, Araki Kimi, Araki Masatake, Choijookhuu Narantsog, Hishikawa Yoshitaka, Chosa Etsuo

ACTA HISTOCHEMICA ET CYTOCHEMICA 55 ( 3 ) 99 - 110 2022

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

Epithelial protein lost in neoplasm (EPLIN) is an actin-associated cytoskeletal protein that plays an important role in epithelial cell adhesion. EPLIN has two isoforms: EPLINα and EPLINβ. In this study, we investigated the role of EPLINβ in osteoblasts using EPLINβ-deficient (EPLINβGT/GT) mice. The skeletal phenotype of EPLINβGT/GT mice is indistinguishable from the wildtype (WT), but bone properties and strength were significantly decreased compared with WT littermates. Histomorphological analysis revealed altered organization of bone spicules and osteoblast cell arrangement, and decreased alkaline phosphatase activity in EPLINβGT/GT mouse bones. Transmission electron microscopy revealed wider intercellular spaces between osteoblasts in EPLINβGT/GT mice, suggesting aberrant cell adhesion. In EPLINβGT/GT osteoblasts, α- and β-catenins and F-actin were observed at the cell membrane, but OB-cadherin was localized at the perinuclear region, indicating that cadherin-catenin complexes were not formed. EPLINβ knockdown in MC3T3-e1 osteoblast cells showed similar results as in calvaria cell cultures. Bone formation markers, such as RUNX2, Osterix, ALP, and Col1a1 mRNA were reduced in EPLINβ knockdown cells, suggesting an important role for EPLINβ in osteoblast formation. In conclusion, we propose that EPLINβ is involved in the assembly of cadherin-catenin complexes in osteoblasts and affects bone formation.

DOI： 10.1267/ahc.22-00027

Remnant-Preserved Single-Bundle Anterior Cruciate Ligament Augmentation in Multi-ligamentous Knee Reconstruction

Tajima T., Yamaguchi N., Morita Y., Yokoe T., Nagasawa M., Ota T., Kawagoe S., Nakamura Y., Chosa E.

Journal of Knee Surgery 36 ( 10 ) 1095 - 1101 2022

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Knee Surgery

This study was conducted to present remnant-preserving anterior cruciate ligament (ACL) augmentation as a useful option for partial ACL injury in multiligament knee injury (MLKI) cases, which may also contribute to conserving graft resources. The present study involved patients diagnosed with MLKI at our institute from Spring 2006 to February 2021. A total of 71 MLKI cases were provided surgery due to knee instability and disability. For every patient, an arthroscopic diagnostic was performed to ensure that ACL tear and a remnant were present. When the ACL remnant was classified into group 2, 3, or 4 of Nakamae's classification, remnant-preserved single bundle ACL augmentation was performed. Graft selection and the combination of injured ligaments were evaluated. The side-to-side difference under an anterior tibial load of 134 N with an arthrometer and the leg symmetry index at 60 degrees/s were measured. The present procedure was performed for five cases (male/female: 4/1, mean age: 33.6 years). The mean follow-up period was 26.4 months. The combination of torn ligaments was as follows: 3 cases of ACL + medial collateral ligament, one case of ACL + posterior cruciate ligament, and one case of ACL + posterolateral corner. An ACL augmentation graft was performed using an ipsilateral gracilis tendon in 2 cases, a contralateral full semitendinosus tendon in 2 cases, and the ipsilateral distal 1/2 of the semitendinosus tendon in 1 case. The mean side-to-side difference was 1.07 ± 0.4 mm. The mean leg symmetry index was 82.6 ± 12.2% in knee extension and 96.3 ± 9.9% in knee flexion. Although the present study was a small case series, the remnant-preserved single-bundle ACL augmentation for MLKI surgery provided good clinical outcome and conserved the graft resource. Even in the MLKI case, this technique is one of the useful surgical options. The level of evidence of this study is level IV (case series).

DOI： 10.1055/s-0042-1749603

Risk factors of loss of knee range of motion after primary anterior cruciate ligament reconstruction following preoperative recovery of knee range of motion

Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.

Journal of Knee Surgery 36 ( 13 ) 1365 - 1373 2022

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Knee Surgery

The loss of knee range of motion (ROM) is not an uncommon complication after anterior cruciate ligament reconstruction (ACLR). However, the risk factors of loss of knee ROM remain debatable. The purpose of this study was to evaluate the incidence and risk factors of loss of knee ROM at 12 months after primary ACLR performed after regaining full knee ROM preoperatively. Consecutive patients who underwent primary ACLR after regaining full ROM between January 2014 and January 2020 were retrospectively reviewed. Patients who received a surgical arthrolysis within 12 months after ACLR or those who had a loss of knee ROM at 12 months postoperatively were defined as the loss of ROM group. Possible risk factors of loss of knee ROM, including patient demographic, preoperative, surgical, and postoperative factors, were assessed. The notch wide index and radiographic parameters of the tibial spines; medial tibial spine height (MTSH)/tibial length (TL), lateral tibial spine height (LTSH)/TL, and tibial spine width (TSW)/TL, were also assessed. A total of 141 patients (141 knees) were included (mean age, 25.8 ± 11.4 years; male/female, 56/85). Of the 141 patients, 3 received surgical arthrolysis within 12 months, and 23 had a loss of knee ROM at 12 months after ACLR. Compared patients with and without loss of knee ROM, significant differences were found in the age (p = 0.04), LTSH/TL (p = 0.02), and TSW/TL (p = 0.02). A multivariate regression analysis showed that the age (odds ratio [OR]; 1.05, 95% confidence interval [CI]: 1.01-1.09, p = 0.02), LTSH/TL (OR: 1.44, 95% CI: 1.01-2.1, p = 0.04), and TSW/TL (OR: 0.79, 95% CI: 0.65-0.97, p = 0.02) were identified as significant independent risk predictors of loss of knee ROM. This study showed that the incidence of loss of knee ROM at 12 months after primary ACLR was 18.4% (26/141). An older age, a higher LTSH/TL and a smaller TSW/TL may be associated with loss of knee ROM at 12 months after ACLR.

DOI： 10.1055/a-1934-0776

The anterior talofibular ligament ratio was greater in young men with generalized joint laxity than in those without generalized joint laxity Reviewed

Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.

Knee Surgery, Sports Traumatology, Arthroscopy 31 ( 5 ) 1994 - 2000 2022

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Knee Surgery, Sports Traumatology, Arthroscopy

Purpose: This study aimed to evaluate the relationship between generalized joint laxity (GJL) and stress ultrasonographic (US) findings of the anterior talofibular ligament (ATFL) of healthy young men. Methods: The ATFL lengths of healthy young men were consecutively measured in the stress and nonstress positions. The ATFL ratio was calculated as an indicator of lateral ankle laxity. GJL was evaluated using the Beighton score (BS), and a BS of ≥ 5 was considered GJL. The manual anterior drawer test (ADT) was also performed. The results of stress US and ADT were compared between subjects with and without GJL, and the correlation between GJL and US findings was examined. Results: A total of 13 subjects with GJL and 95 without GJL were included in the study. The mean BSs in the GJL and no-GJL groups were 5.9 ± 0.9 and 1.1 ± 1.3, respectively (p < 0.0001). The GJL group showed a higher grade of ADT than the no-GJL group (p < 0.0001). Significant differences were found in the stress ATFL length (23.6 ± 1.8 mm vs. 21.7 ± 1.8 mm, p = 0.002) and ATFL ratio (1.15 ± 0.06 vs. 1.07 ± 0.03, p < 0.0001) between the GJL and no-GJL groups. Spearman’s correlation coefficients showed a moderate correlation between the BS and ATFL ratio (r = 0.45, p < 0.0001). Conclusion: The present study showed significant differences in the ATFL ratio and stress ATFL length between young men with and without GJL. The BS was moderately correlated with the lateral ankle laxity in this population. Level of evidence: Level IV.

DOI： 10.1007/s00167-022-07109-w

化膿性肩関節炎後にリバース型人工肩関節全置換術を施行した1例

泉俊彦, 長澤誠, 川越秀一, 大田智美, 帖佐悦男

肩関節 46 ( 1 ) 254 - 257 2022

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本肩関節学会

化膿性肩関節炎後の機能障害に対しリバース型人工肩関節全置換術（RSA）を施行する前には，感染制御状態を評価する必要があるがその評価に統一した見解は得られていない．今回74歳男性に対しRSAを実施するにあたり，関節リウマチの併存から感染制御判断に難渋した症例を経験した．現状単一の検査で感染を否定することは困難であるため，総合的な評価を行ったうえでRSAを含めた治療戦略を確立する必要がある

DOI： 10.11296/katakansetsu.46.254

Depletion of high-mobility group box 2 causes seminiferous tubule atrophy via aberrant expression of androgen and estrogen receptors in mouse testis†

Evaluation of a proposed knee brace on the basis of the changes in fot center of pressure and surface electromygraphy of lower limb muscle. Reviewed

Gang DENG　Etsuo CHOSA　Koki OUCHI　Shigeaki MIYAZAKI　Toshiki ABE　Hitonobu KOIKE

43 309 - 318 2022

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Clinical Biomechanics

Remnant-Rreserved Single-Bundle Anterior Cruciate Ligament Augmentation in Multi-ligamentous Knee Reconstruction Reviewed

Takuya Tajima,MD, PhD NamiYamaguchi,MD,PhD Yudai Morita,MD Takuji Yokoe,MD Makotot Nagasawa,MD Tomomi Ota,MD Shuichi Kawagoe,MD Yoshihiro Nakamura, MD Etsuo Chosa,MD,PhD

Thieme 2022

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1055/s-0042-1749603.

Sugita N., Choijookhuu N., Yano K., Lee D., Ikenoue M., Fidya , Taniguchi N., Chosa E., Hishikawa Y.

Biology of reproduction 105 ( 6 ) 1510 - 1520 2021.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biology of reproduction

High-mobility group box 2, a chromatin-associated protein that interacts with deoxyribonucleic acid, is implicated in multiple biological processes, including gene transcription, replication, and repair. High-mobility group box 2 is expressed in several tissues, including the testis; however, its functional role is largely unknown. Here, we elucidated the role of high-mobility group box 2 in spermatogenesis. Paraffin-embedded testicular tissues were obtained from 8-week-old and 1-year-old wild-type and knock-out mice. Testis weight and number of seminiferous tubules were decreased, whereas atrophic tubules were increased in high-mobility group box 2-depleted mice. Immunohistochemistry revealed that atrophic tubules contained Sertoli cells, but not germ cells. Moreover, decreased cell proliferation and increased apoptosis were demonstrated in high-mobility group box 2-depleted mouse testis. To elucidate the cause of tubule atrophy, we examined the expression of androgen and estrogen receptors, and the results indicated aberrant expression of androgen receptor and estrogen receptor alpha in Sertoli and Leydig cells. Southwestern histochemistry detected decreased estrogen response element-binding sites in high-mobility group box 2-depleted mouse testis. High-mobility group box 1, which has highly similar structure and function as high-mobility group box 2, was examined by immunohistochemistry and western blotting, which indicated increased expression in testis. These findings indicate a compensatory increase in high-mobility group box 1 expression in high-mobility group box 2 knock-out mouse testis. In summary, depletion of high-mobility group box 2 induced aberrant expression of androgen receptor and estrogen receptor alpha, leading to decreased germ cell proliferation and increased apoptosis which resulted in focal seminiferous tubule atrophy.

DOI： 10.1093/biolre/ioab187

Turner’s syndrome associated with discoid lateral meniscus and Blount’s disease: a case report

Clinical and Radiographic Outcomes of Double-Bundle Anterior Cruciate Ligament Reconstruction for Asian Patients with Bone-Patellar Tendon-Bone and Gracilis Tendon Grafts: A Matched-Control Comparison

Takuya Tajima, Nami Yamaguchi, Yudai Morita, Makoto Nagasawa, Tomomi Ota, Yoshihiro Nakamura, Takuji Yokoe, Etsuo Chosa

Journal of Knee Surgery 34 ( 14 ) 1545 - 1554 2021.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1055/s-0040-1710376.

Kita T., Tajima T., Chosa E.

BMC Musculoskeletal Disorders 22 ( 1 ) 449 2021.12

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Musculoskeletal Disorders

Background: Turner’s syndrome, discoid meniscus, and Blount’s disease have all been studied in isolation, but, to the best of our knowledge, there have been no studies reporting a patient with all three. Thus, the first case of Turner’s syndrome with discoid meniscus and Blount’s disease is presented. Case presentation: A 5-year-old Japanese girl with a history of Turner’s syndrome and Blount’s disease complained of pain in her left knee. Magnetic resonance imaging showed a discoid lateral meniscus tear, and arthroscopic partial meniscectomy was performed, providing a good outcome. Conclusions: In this report, some possible explanations regarding the concomitant presence of these three diseases are discussed. A possible explanation in this case is that the patient with Turner’s syndrome had a discoid lateral meniscus that might have been induced by some genetic factors associated with Turner’s syndrome, and then the discoid lateral meniscus might have been the mechanical stress that caused Blount’s disease.

DOI： 10.1186/s12891-021-04336-z

The current clinical practice of general orthopaedic surgeons in the treatment of lateral ankle sprain: a questionnaire survey in Miyazaki, Japan

Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.

BMC Musculoskeletal Disorders 22 ( 1 ) 636 2021.12

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Musculoskeletal Disorders

Background: Lateral ankle sprain (LAS) is one of the most common musculoskeletal injuries. Numerous studies regarding LAS have been performed. However, there are few studies evaluating the current clinical practice of orthopaedic surgeons regarding LAS. The purpose of this study was to evaluate the current clinical practice of general orthopaedic surgeons in the treatment of LAS. Methods: A questionnaire survey was conducted from September 2020 to December 2020 in Miyazaki, Japan, to evaluate the clinical practice of general orthopaedic surgeons in the treatment of LAS. The survey was composed of 12 questions that were developed with consideration of the recommendations in the current clinical practice guidelines (CPGs) published by the Dutch orthopaedic society. The questions in this study were focused on the diagnosis, conservative treatment, rehabilitation, and the criteria for return to sports (RTS). Results: The survey response rate was 82.7% (129/156). Among the respondents, 95.3% did not consider the Ottawa Ankle Rules in the decision to perform plain radiography for patients. Rehabilitation following LAS was performed in 58.9% of patients. Eighty-five (65.9%) of the surgeons used only one factor as the criterion for RTS. The absence of pain was the most frequently used criterion (45.7%). No objective criteria were used for the RTS decision in athletes with LAS. Conclusions: The present study suggested that most general orthopaedic surgeons do not provide the care for patients with LAS recommended by the current CPGs. No objective criteria for the RTS decision are used for athletes with LAS.

DOI： 10.1186/s12891-021-04527-8

Shadow pitching deviates ball release position: kinematic analysis in high school baseball pitchers. International journal

Shigeaki Miyazaki, Go Yamako, Koji Totoribe, Tomohisa Sekimoto, Yuko Kadowaki, Kurumi Tsuruta, Etsuo Chosa

BMC sports science, medicine & rehabilitation 13 ( 1 ) 26 - 26 2021.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Although shadow pitching, commonly called "towel drill," is recommended to improve the throwing motion for the rehabilitation of pitching disorders before the initiation of a throwing program aimed at returning to throwing using a ball, the motion differs from that of normal throwing. Learning improper motion during ball release (BR) may increase shoulder joint forces. Abnormal throwing biomechanics leads to injures. However, there has been no study of shadow pitching focusing on the BR position. The purpose of the present study was to evaluate the BR position and kinematic differences between shadow pitching and normal throwing. In addition, the effect of setting a target guide for BR position on throwing motion was examined in shadow pitching. METHODS: The participants included in this study were 20 healthy male students who were overhand right-handed pitchers with no pain induced by a throwing motion. Participants performed normal throwing (task 1), shadow pitching using a hand towel (task 2), and shadow pitching by setting a target of the BR position (task 3). A motion capture system was used to evaluate kinematic differences in throwing motions, respectively. Examination items comprised joint angles and the differences in BR position. RESULTS: BR position of task 2 shifted significantly toward the anterior, leftward, and downward directions compared with task 1. The distance of BR position between tasks 1 and 2 was 24 ± 10%. However, task 3 had decreased BR deviation compared with task 2 (the distance between 3 and 1 was 14 ± 7%). Kinematic differences were observed among groups at BR. For shoulder joint, task 2 showed the highest value in abduction and horizontal adduction among groups. In spine flexion, left rotation and thorax flexion, task 2 was significantly higher than task 1. Task 3 showed small differences compared with task 1. CONCLUSIONS: The BR position of shadow pitching deviated significantly in the anterior, leftward, and downward directions compared with normal throwing. Furthermore, we demonstrated that the setting of BR target reduces this deviation. Thus, the target of BR position should be set accurately during shadow pitching exercises in the process of rehabilitation.

DOI： 10.1186/s13102-021-00255-7

Biomechanical effect of intertrochanteric curved varus osteotomy on stress reduction in femoral head osteonecrosis: a finite element analysis

Wang Y., Yamako G., Okada T., Arakawa H., Nakamura Y., Chosa E.

Journal of Orthopaedic Surgery and Research 16 ( 1 ) 465 2021.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Surgery and Research

Background: Intertrochanteric curved varus osteotomy (CVO) has been widely used to remove the necrotic bone away from the weight-bearing portion in the treatment of osteonecrosis of the femoral head (ONFH). However, whether all types of necrosis will benefit from CVO, in terms of the stress level, the effect of different center-edge (CE) angles of acetabulum on stress distribution of necrosis after CVO, and the relationship between the intact ratio and the stress of necrosis, has never been addressed. The purpose of the study was to evaluate the influence of CVO on the stress reduction in necrotic bone using a finite element analysis (FEA) with different CE angles. Methods: CVO finite element models of the hip joint were simulated with a lesion of 60°. The osteotomy angles were divided into four configurations (15°, 20°, 25°, and 30°), and three types (A, B, and C1) of lesions were established based on the Japanese Investigation Committee (JIC) classification. In addition, two CE angles (18° and 33°) of acetabulum were considered. The maximum and mean von Mises stress were analyzed in terms of the necrotic bone by a physiological loading condition. Moreover, the correlation of the intact ratio measured in 3D and the stress distribution after CVO was analyzed. Results: Stress reduction was obtained after CVO. For type B, the CVO angle was 20° (0.61 MPa), and for type C1, the CVO angle was 30° (0.77 MPa), if the mean stress level was close to type A (0.61 MPa), as a standard. The maximum and mean von Mises stress were higher in the CE angle of 18°models, respectively. The intact ratio measured in 3D had a good negative correlation with stress after CVO and had more influence on stress distribution in comparison to other geometric parameters. Conclusions: For making decisions about the biomechanics of CVO, a CVO angle of > 20° was recommended for type B and > 30° was safe for type C1. The risk of progressive collapse was increased in the insufficient situation of the weight-bearing portion after CVO. The intact ratio could provide information about clinical outcomes and stress distribution after CVO.

DOI： 10.1186/s13018-021-02614-z

Hanging radiograph in idiopathic scoliosis patients: significance as a preoperative stress X-ray

Kuroki H., Nagai T., Chosa E., Tajima N.

Journal of Spine Surgery 7 ( 4 ) 495 - 501 2021.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Spine Surgery

Background: Before corrective surgery for idiopathic scoliosis, the stress X-rays are indispensable to collect information regarding the reducibility of deformity, deciding fusion levels, and categorizing curve types and so on. The hanging radiograph has not been conducted preoperatively so far as known. The objective of this study was to investigate retrospectively the significance of the hanging radiograph for prediction of the curve correction with surgical procedure by comparing with the side-bending and the traction radiographs. Methods: The subjects enrolled in current study were 22 cases of idiopathic scoliosis who performed posterior instrumentation and fusion by ISOLA method between 2008 and 2014. They included 2 males and 20 females, with a mean age of 16 years and 8 months. The type of curves by Lenke classification were type 1 in 20 cases, type 2 in 1 case, and type 3 in 1 case. We investigated the correction rates of main thoracic curves in side-bending, traction, and hanging positions and compared them with that after surgery. In addition, correction indices were also calculated and compared among these stress X-rays. Results: The correction rate after surgery was 65.9% that was statistically higher than those in side-bending (44.2%), traction (46.6%), and hanging (22.1%) positions. There were statistical correlations between the correction rates after surgery and in side-bending position (R=0.73) and those after surgery and in traction position (R=0.57). However, there was no statistical correlation between the correction rates after surgery and in hanging position (R=-0.01). With regard to the correction indices, that in hanging position (3.67) was statistically higher than those in side-bending (1.51) and traction (1.45) positions. Conclusions: The correction rates in side-bending and traction positions seem to be useful to estimate the amount of curve correction before surgery. Whereas, that in hanging position did not have any significance as preoperative evaluation.

DOI： 10.21037/jss-21-74

特集大腿骨近位部骨折治療のエキスパートを目指そう頚部骨折大腿骨頚部骨折の分類

日吉優, 帖佐悦男

関節外科　基礎と臨床 40 ( 11 ) 1129 - 1136 2021.11

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000000803

特集大腿骨近位部骨折治療のエキスパートを目指そう introduction

帖佐悦男

関節外科　基礎と臨床 40 ( 11 ) 1111 - 1111 2021.11

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000000800

特集整形外科領域におけるリアルワールドデータを用いた研究四肢長管骨開放骨折レジストリー

石井桂輔, 黒住健人, 鈴木卓, 渡部欣忍, 井口浩一, 帖佐悦男

整形･災害外科 64 ( 12 ) 1513 - 1521 2021.11

Publishing type：Research paper (scientific journal) Publisher：金原出版

DOI： 10.18888/se.0000001939

A case of nail-patella syndrome with osteochondral lesion of the lateral femoral condyle accompanied with anomalies of anterior horns of the menisci and lateral femoral condyle

28 ( 6 ) 1543 - 1547 2021.10

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jos.2021.09.004

特集運動器エコーのエキスパートを目指そう introduction

帖佐悦男

関節外科　基礎と臨床 40 ( 14 ) 7 - 7 2021.10

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000000770

Exploring whole-body kinematics when eating real foods with the dominant hand in healthy adults

Nakatake J., Totoribe K., Arakawa H., Chosa E.

PLoS ONE 16 ( 10 October ) e0259184 2021.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：PLoS ONE

Despite the importance of eating movements to the rehabilitation of neurological patients, information regarding the normal kinematics of eating in a realistic setting is limited. We aimed to quantify whole-body three-dimensional kinematics among healthy individuals by assessing movement patterns in defined phases while eating real food with the dominant hand in a seated position. Our cross-sectional study included 45 healthy, right-hand dominant individuals with a mean age of 27.3 ± 5.1 years. Whole-body kinematics (joint angles of the upper limb, hip, neck, and trunk) were captured using an inertial sensor motion system. The eating motion was divided into four phases for analysis: reaching, spooning, transport, and mouth. The mean joint angles were compared among the phases with Friedman’s analysis of variance. The maximum angles through all eating phases were 129.0° of elbow flexion, 32.4° of wrist extension, 50.4° of hip flexion, 6.8° of hip abduction, and 0.2° of hip rotation. The mean shoulder, elbow, and hip joint flexion angles were largest in the mouth phase, with the smallest being the neck flexion angle. By contrast, in the spooning phase, the shoulder, elbow, and hip flexion were the smallest, with the largest being the neck flexion angle. These angles were significantly different between the mouth and spooning phases (p < 0.008, Bonferroni post hoc correction). Our results revealed that characteristic whole-body movements correspond to each phase of realistic eating in healthy individuals. This study provides useful kinematic data regarding normal eating movements, which may inform whole-body positioning and movement, improve the assessment of eating abilities in clinical settings, and provide a basis for future studies.

DOI： 10.1371/journal.pone.0259184

高校空手選手における貧血調査

木戸義隆, 田島卓也, 山口奈美, 長澤誠, 大田智美, 森田雄大, 横江琢示, 川越秀一, 帖佐悦男

整形外科と災害外科 70 ( 4 ) 703 - 706 2021.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【目的】高校空手選手の貧血について調査したので報告する．【対象・方法】2012-2019年の宮崎県某高校空手部1年生68名（男子39名，女子29名）を対象とし，2015-2019年の国民体育大会宮崎県代表候補選手のうち高校1年生160名（男子114名，女子46名）と比較した．【結果】男子はHb＜13 g/dL，女子はHb＜12 g/dLを貧血とした．【結果】空手選手では30.8％（男子28.2％，女子34.5％）に貧血を認め，全例正球性貧血だった．他競技の貧血例は陸上女子選手1例だった．空手選手の貧血群と非貧血群で血清鉄，網赤血球，フェリチン，不飽和鉄結合能に有意差はなく，貧血と鉄欠乏に関連はなかった．【考察】空手部の貧血が全例正球性貧血であったことから，空手の突き動作に伴い頻回に足を踏み込む動作で足底血管にて溶血をきたしたと考えた．空手選手のメディカルサポートの際には，貧血を考慮する必要があると考えられた．

DOI： 10.5035/nishiseisai.70.703

上下肢3か所に多発した腱鞘巨細胞腫の治療経験

當瀬雅大, 大田智美, 坂本武郎, 田島卓也, 山口奈美, 長澤誠, 森田雄大, 横江琢示, 川越秀一, 帖佐悦男, 川野啓介

整形外科と災害外科 70 ( 4 ) 749 - 753 2021.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

〔はじめに〕腱鞘巨細胞腫は手指に多く発生することが知られているが，多発例の報告は稀である．上下肢3か所に多発した稀な腱鞘巨細胞腫の症例を経験したので報告する．〔症例〕45歳男性で，約4年前に左示指に釣り針が刺さった同時期より左示指，左肘，左膝の腫瘤を自覚した．MRIで3か所とも関節外にT1強調画像で等から軽度高信号，T2強調画像で低信号，造影で不均一に造影される境界明瞭な腫瘤を認めた．左膝腫瘤の切除生検を施行した結果，腱鞘巨細胞腫の診断に至った．生検と画像所見より，多発腱鞘巨細胞腫と判断し，3か所同時に腫瘍摘出術を施行し，最終診断もすべて腱鞘巨細胞腫であった．〔考察〕我々が渉猟しえた限りでは多発例は32報告で，上下肢に及ぶ2か所発生例，3病変の発生例はそれぞれ1例のみであった．本症例は上下肢に及ぶ3病変の多発例であり，稀な症例であると思われた．〔結語〕本症例は再発リスク因子が多く，今後の慎重な経過観察が必要と考える．

DOI： 10.5035/nishiseisai.70.749

点状軟骨異形成症に伴う環軸椎亜脱臼に対して手術した1例

帖佐直紀, 濱中秀昭, 黒木修司, 比嘉聖, 永井琢哉, 李徳哲, 黒木智文, 帖佐悦男

整形外科と災害外科 70 ( 3 ) 374 - 377 2021.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【抄録】乳児の頸椎疾患に対しての手術は稀で本邦でも報告数は少ない．今回，点状軟骨異形成症の乳児に対して手術を施行した稀な症例を経験したので報告する．【症例】生後50日，女児．妊娠37週2日で出生．胎児期から鼻の低形成が疑われていた．出生時に第1啼泣なく陥没呼吸が強いため人工呼吸器にて管理された．画像所見にて点状石灰化や環軸椎亜脱臼による脊髄圧迫の所見の他，鼻根部低形成などの特徴的顔貌から点状軟骨異形成症が疑われた．手術目的に転院となり，環椎後弓切除術と大後頭孔減圧術を施行した．術後は四肢の麻痺や筋力低下なく経過し，術後の画像所見でも圧迫が解除されていた．【考察】点状軟骨異形成症の頸椎病変に対する治療の基準は確立されていない．本症例では生後50日と乳児のため環椎後弓切除術と大後頭孔減圧術のみとし，今後不安定性が残存する場合は固定も考慮される．児の年齢や罹患場所に応じた治療を選択する事が重要である．

DOI： 10.5035/nishiseisai.70.374

長時間の砕石位手術後に下腿のWell-leg compartment syndromeを来した一例

神谷俊樹, 日吉優, 坂本武郎, 舩元太郎, 中村嘉宏, 山口洋一朗, 平川雄介, 今里浩之, 帖佐悦男

整形外科と災害外科 70 ( 4 ) 595 - 598 2021.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【はじめに】コンパートメント症候群の中でも下肢の不適切な体位が原因となるWell-leg compartment syndrome（WLCS）の一例を経験したので報告する．【症例】38歳男性の直腸カルチノイドに対して砕石位で腹腔鏡補助下低位前方切除術・回腸人工肛門造設術を施行した．手術時間は6時間39分，麻酔時間は8時間5分であった．覚醒時より左下腿の疼痛を自覚し，下肢挙上台（レビテーター）に一致した圧迫痕と腫脹を認めた．血液検査にて経時的なクレアチンキナーゼ（CK）の上昇，コンパートメント内圧の上昇を認め，同日筋膜切開を行った．切開術直後より疼痛は改善し，後遺症を残すことなく経過良好であった．【考察】WLCSは砕石位で最も多いと言われる．砕石位は他科で汎用されるが，コンパートメント症候群は他科では馴染みの少ない病態であり，我々整形外科医が率先して手術室スタッフを含めた知識の共有を行うことで，予防，早期発見・治療が可能と思われる．

DOI： 10.5035/nishiseisai.70.595

Real-time action recognition system for elderly people using stereo depth camera

Zin T.T., Htet Y., Akagi Y., Tamura H., Kondo K., Araki S., Chosa E.

Sensors 21 ( 17 ) 2021.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Sensors

Smart technologies are necessary for ambient assisted living (AAL) to help family mem-bers, caregivers, and health-care professionals in providing care for elderly people independently. Among these technologies, the current work is proposed as a computer vision-based solution that can monitor the elderly by recognizing actions using a stereo depth camera. In this work, we intro-duce a system that fuses together feature extraction methods from previous works in a novel combination of action recognition. Using depth frame sequences provided by the depth camera, the system localizes people by extracting different regions of interest (ROI) from UV-disparity maps. As for feature vectors, the spatial-temporal features of two action representation maps (depth motion appearance (DMA) and depth motion history (DMH) with a histogram of oriented gradients (HOG) descriptor) are used in combination with the distance-based features, and fused together with the automatic rounding method for action recognition of continuous long frame sequences. The experimental results are tested using random frame sequences from a dataset that was collected at an elder care center, demonstrating that the proposed system can detect various actions in real-time with reasonable recognition rates, regardless of the length of the image sequences.

DOI： 10.3390/s21175895

Internal Fixation of a Lateral Inverted Osteochondral Fracture of the Talus (LIFT) Lesion Using an Innovative Surgical Approach: Inverting the Capsulo-Lateral Fibulotalocalcaneal Ligament (LFTCL)–Fibular Periosteum Complex

Yokoe T., Tajima T., Yamaguchi N., Ota T., Nagasawa M., Morita Y., Chosa E.

Journal of Foot and Ankle Surgery 60 ( 5 ) 1054 - 1059 2021.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Foot and Ankle Surgery

Osteotomy of the distal fibula or anterolateral corner of the tibia is usually required to fix a displaced osteochondral fracture of the talus that is located central to posterior area of the lateral talar dome. However, osteotomy is an invasive procedure and is associated with complications, including nonunion, persistent pain, and hardware-related problems. Lateral inverted osteochondral fracture of the talus (LIFT) lesion is an extremely rare type of displaced osteochondral lesion of the talus. We describe a case in which a LIFT lesion was fixed using an innovative surgical approach, inverting capsulo-lateral fibulotalocalcaneal ligament (LFTCL)–fibular periosteum complex, with a favorable short-term clinical outcome.

DOI： 10.1053/j.jfas.2021.03.005

Locomotive Organ Disorder in Children and Prevention of Locomotive Syndrome

点状軟骨異形成症に伴う環軸椎亜脱臼に対して手術した1例 Reviewed

帖佐直紀, 濱中秀昭, 黒木修司, 比嘉聖, 永井琢哉, 李徳哲, 黒木智文, 帖佐悦男

整形外科と災害外科 70 ( 3 ) 374 - 377 2021.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

長時間の砕石位手術後に下腿のWell-leg compartment syndromeを来した一例 Reviewed

神谷俊樹, 日吉優, 坂本武郎, 舩元太郎, 中村嘉宏, 山口洋一朗, 平川雄介, 今里浩之, 帖佐悦男

整形外科と災害外科 70 ( 4 ) 595 - 598 2021.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

高校空手選手における貧血調査 Reviewed

木戸義隆, 田島卓也, 山口奈美, 長澤誠, 大田智美, 森田雄大, 横江琢示, 川越秀一, 帖佐悦男

整形外科と災害外科 70 ( 4 ) 703 - 706 2021.9

Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

上下肢3ヶ所に多発した腱鞘巨細胞腫の治療経験 Reviewed

當瀬雅大, 大田智美, 坂本武郎, 田島卓也, 山口奈美, 長澤誠, 森田雄大, 横江琢示, 川越秀一, 帖佐悦男, 川野啓介

整形外科と災害外科 70 ( 4 ) 749 - 753 2021.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

Chosa Etsuo

The Japanese Journal of Rehabilitation Medicine 58 ( 8 ) 925 - 932 2021.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association of Rehabilitation Medicine

DOI： 10.2490/jjrmc.58.925

Sarcopenia, Ectopic Fat Infiltration into the Lumbar Paravertebral Muscles, and Lumbo-Pelvic Deformity in Older Adults Undergoing Lumbar Surgery.

Lee D, Kuroki T, Nagai T, Kawano K, Higa K, Kurogi S, Hamanaka H, Chosa E

Spine 47 ( 2 ) E46 - E57 2021.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Spine

Study Design.A retrospective analysis of a prospective, non-randomized cohort dataset.Objective.To cross-sectionally examine the prevalence of sarcopenia and the association between spine-pelvic deformity and skeletal muscle volume loss and ectopic fat infiltration into lumbar paravertebral muscles (PVMs) in patients who underwent lumbar surgery.Summary of Background Data.Muscle quality deterioration has been considered the main pathology of sarcopenia, reducing muscle strength directly. The qualitative deterioration as well as volume loss in PVM, which contributes significantly to core body extension, might cause aging-related spine deformity.Methods.In total, 184 patients were included. Sarcopenia was diagnosed at baseline, and all patients underwent whole-body X-ray. The amount of fat in lumbar PVM was evaluated with the Goutallier classification in magnetic resonance imaging findings. The expression of adipogenesis- and atrophy-promoting factors in PVM was evaluated with quantitative polymerase chain reaction.Results.In total, 36.1% of adults aged ≥60 years were diagnosed with sarcopenia. The values of skeletal muscle indexes of the limb and trunk were inversely correlated with the sagittal vertical axis, pelvic tilt (PT), and pelvic incidence minus lumbar lordosis (PI-LL) values. The PT and PI-LL were greater, PVM area was smaller, and Goutallier grade was greater in sarcopenic adults than in non-sarcopenic older adults. Additionally, the PVM area correlated with the LL value, and Goutallier's grade correlated with the PT and PI-LL values. Moreover, the amount of ectopic fat in PVMs inversely correlated with skeletal muscle indexes. The expression levels of atrophy gene-1 and muscle ring-finger protein-1 did not differ between the groups and did not correlate with the PVM area. In contrast, the expression of Pparg and Cebpa was upregulated in sarcopenic older adults, where it correlated with Goutallier's grade.Conclusion.The volume loss of skeletal muscle, including lumbar PVM, and ectopic fat infiltration into the PVM, may cause the lumbo-pelvic deformity.Level of Evidence: 3.

DOI： 10.1097/BRS.0000000000004175

Total Knee Arthroplasty Improved Locomotive Syndrome in Knee Osteoarthritis Patients: A Prospective Cohort Study Focused on Total Clinical Decision Limits Stage 3

Miyazaki S., Yoshinaga S., Tsuruta K., Hombu A., Fujii Y., Arakawa H., Sakamoto T., Chosa E.

BioMed Research International 2021 3919989 2021.6

Language：English Publishing type：Research paper (scientific journal) Publisher：BioMed Research International

Purpose. The purpose of this study is to investigate the treatment efficacy of total knee arthroplasty (TKA) on locomotive syndrome (LS) focusing on total clinical decision limit (CDL) stage 3 leading to revealing the motor function indicators that can predict LS improvement in knee osteoarthritis patients who had received TKA. Methods. This prospective cohort study was conducted in 47 patients evaluated as total CDL stage 3 before TKA who received primary TKA on the operated side and were diagnosed with Kellgren-Lawrence grade 2, 3, or 4 knee osteoarthritis on the nonoperated side. LS was evaluated using stand-up test, two-step test, and 25-Question Geriatric Locomotive Function Scale. In addition, the motor function indicators which could predict the LS improvement were examined. All assessments were conducted before TKA and three months after TKA. Results. Of the 47 subjects who were evaluated to be in total CDL stage 3 before TKA, 13 patients (27.7%) were determined to show improvements in total CDL. From the result of the decision tree analysis, when the CDL of the two-step test before TKA was 1 or less, the improvement rate was 83.3%. Even if the CDL of the two-step test before TKA was higher than 1 and if the 3 m-Timed Up and Go test (3m-TUG) before TKA was 9.6 or less, the improvement rate was 50%. Conclusions. As of three months after surgery, TKA can improve LS in about 30% of knee osteoarthritis patients. A two-step test before TKA and 3m-TUG before TKA can be used as motor function indicators to predict LS improvement. This study provides useful information for setting the goal for rehabilitation prior to surgery.

DOI： 10.1155/2021/3919989

Symptomatic discoid lateral meniscus shows a relationship between types and tear patterns, and between causes of clinical symptom onset and the age distribution

Yamaguchi N., Chosa E., Tajima T., Morita Y., Yokoe T.

Knee Surgery, Sports Traumatology, Arthroscopy 30 ( 4 ) 1436 - 1442 2021.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Knee Surgery, Sports Traumatology, Arthroscopy

Purpose: Discoid meniscus is a congenital abnormality of the lateral meniscus and is seen more frequently in East Asia. The purpose of this study was to retrospectively assess the relationship between discoid lateral meniscus (DLM) types and tear patterns and causes of age-specific clinical symptom onset. Methods: Of 1650 arthroscopic surgeries over a 20-year period, 138 (105 patients) were performed for DLM and were evaluated in this study. The mean age at surgery was 21.5 ± 15.8 years. The DLM type was classified by Watanabe’s classification, and tear patterns were classified by the modified Bin’s classification as simple horizontal, complicated horizontal, longitudinal, radial, complex, and no tear. Additionally, patients were divided by age group (< 10, 10–19, 20–39, 40–59, and ≥ 60 years) and classified according to the causes of clinical symptom onset as follows: sports activities, minor trauma in daily living, and no traumatic episode. Results: The DLM was complete in 78 (56.5%) knees and incomplete in 60 (43.5%); no Wrisberg type DLM was observed. Simple horizontal and complicated horizontal tears were significantly more frequent in complete DLM, whereas radial tears and no tears were significantly more frequent in incomplete DLM (p < 0.0001). When classified by age group, 74 (53.6%) knees with DLMs were found in teenagers. Sports activities caused symptom onset significantly more often in teenagers, no traumatic episode caused symptom onset in patients aged < 10 years, and minor trauma in daily living caused symptom onset in patients aged 40–59 years and ≥ 60 years (p < 0.0001). No relationship was found between the age distribution and tear patterns; however, the absence of tears tended to be more common in teenaged patients, and complicated horizontal tears were more common in patients over 20 years of age. Conclusion: Symptomatic DLM occurred most often in teenagers. A relationship was identified between the DLM types and tear patterns, which could be helpful in preoperative planning. Causes of clinical symptom onset in patients with DLM were characterised by age group, which might help clinicians to suspect the presence of DLM. Level of evidence: Level IV.

DOI： 10.1007/s00167-021-06635-3

Non-anatomical placement adversely affects the functional performance of the meniscal implant: a finite element study

Shriram D., Yamako G., Kumar G.P., Chosa E., Cui F., Subburaj K.

Biomechanics and Modeling in Mechanobiology 20 ( 3 ) 1167 - 1185 2021.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Biomechanics and Modeling in Mechanobiology

Non-anatomical placement may occur during the surgical implantation of the meniscal implant, and its influence on the resulting biomechanics of the knee joint has not been systematically studied. The purpose of this study was to evaluate the biomechanical effects of non-anatomical placement of the meniscal implant on the knee joint during a complete walking cycle. Three-dimensional finite element (FE) analyses of the knee joint were performed, based on the model developed from magnetic resonance images and the loading conditions derived from the gait pattern of a healthy male subject, for the following physiological conditions: (i) knee joint with intact native meniscus, (ii) medial meniscectomized knee joint, (iii) knee joint with anatomically placed meniscal implant, and (iv) knee joint with the meniscal implant placed in four different in vitro determined non-anatomical locations. While the native menisci were modeled using the nonlinear hyperelastic Holzapfel–Gasser–Ogden (HGO) constitutive model, the meniscal implant was modeled using the isotropic hyperelastic neo-Hookean model. Placement of the meniscal implant in the non-anatomical lateral-posterior and lateral-anterior locations significantly increased the peak contact pressure in the medial compartment. Placement of the meniscal implant in non-anatomical locations significantly altered the tibial rotational kinematics and increased the total force acting at the meniscal horns. Results suggest that placement of the meniscal implant in non-anatomical locations may restrain its ability to be chondroprotective and may initiate or accelerate cartilage degeneration. In conclusion, clinicians should endeavor to place the implant as closest as possible to the anatomical location to restore the normal knee biomechanics.

DOI： 10.1007/s10237-021-01440-w

特集ロコモティブシンドロームの現況 Ⅵ.疾患とロコモ 8.人工股関節術後リハビリテーション

中村嘉宏, 帖佐悦男

整形外科 72 ( 6 ) 686 - 689 2021.5

Publishing type：Research paper (scientific journal) Publisher：南江堂

DOI： 10.15106/j_seikei72_686

特集ロコモティブシンドロームの現況 Ⅴ.ロコモ広報と地域活動･検診の実践 2.ロコモザワールド宮崎構想

帖佐悦男

整形外科 72 ( 6 ) 654 - 658 2021.5

Publishing type：Research paper (scientific journal) Publisher：南江堂

DOI： 10.15106/j_seikei72_654

連載創刊40周年記念特別企画オンライン座談会｢整形外科学×『関節外科』40年の歩み｣　後編

帖佐悦男, 筒井廣明, 吉矢晋一

関節外科　基礎と臨床 40 ( 5 ) 577 - 579 2021.5

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000000643

A hand-worn inertial measurement unit for detection of bat–ball impact during baseball hitting

Punchihewa N.G., Arakawa H., Chosa E., Yamako G.

Sensors 21 ( 9 ) 2021.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Sensors

Swinging a baseball bat at a pitched ball takes less than half of a second. A hitter uses his lower extremities to generate power, and coordination of the swing motion gradually transfers power through the trunk to the upper extremities during bat–ball impact. The most important instant of the baseball swing is at the bat–ball impact, after which the direction, speed, height, and distance of the hit ball determines whether runs can be scored. Thus, analyzing the biomechanical parameters at the bat–ball impact is useful for evaluating player performance. Different motion-capture systems use different methods to identify bat–ball impact. However, the level of accuracy to detect bat–ball impact is not well documented. The study aim was to examine the required accuracy to detect bat–ball impact timing. The results revealed that ±2 ms accuracy is required to report trunk and hand kinematics, especially for higher-order time-derivatives. Here, we propose a new method using a hand-worn inertial measurement unit to accurately detect bat–ball impact timing. The results of this study will be beneficial for analyzing the kinematics of baseball hitting under real-game conditions.

DOI： 10.3390/s21093002

Association between long-term hospitalization for mental illness and locomotive syndrome.

治療に難渋した浅大腿動脈損傷を伴う大腿骨転子下骨折の1例 Reviewed

福嶋研人, 塩月康弘, 今里浩之, 日吉優, 中村嘉宏, 帖佐悦男

骨折 43 ( 3 ) 702 - 704 2021.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本骨折治療学会

手関節疼痛のある関節リウマチ患者における脱着式保温素材を用いたリストサポーター装着時の即時効果に関する検討

前田翔吾, 濱田浩朗, 黒木友希, 横山茉未, 帖佐悦男, 鳥取部光司

日本ハンドセラピィ学会誌 13 ( 2 ) 107 - 110 2021.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本ハンドセラピィ学会

Yusuke Ishibashi, Hideki Arakawa, Sae Uezono, Sosuke Kitakaze, Munetsugu Kota, Shinichi Daikuya, Junichi Hirakawa, Takeshi Nakamura, Etsuo Chosa

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 27 ( 2 ) 473 - 477 2021.4

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Patients in psychiatric care wards face serious problems in terms of declining physical function due to aging and long-term hospitalization. This study aimed to determine the current status of locomotive syndrome (LS) in long-term inpatients in psychiatric care wards and to clarify the factors associated with LS risk severity. METHODS: The study included 84 patients admitted to psychiatric care wards who underwent the LS stage test. We investigated the participants' age, length of stay, antipsychotic drug use, body mass index, and activities of daily living were assessed and analyzed the correlations between the LS stage test and each assessment item. RESULTS: The participants' mean age was 60.0 ± 13.6 years, with those aged ≥60 years comprising nearly 60% of the sample. The participants' mean length of stay was 10.5 ± 12.0 years, and over half of the patients stayed >5 years: 17.9% stayed between 5 and 10 years, while 36.9% stayed ≥10 years. Nearly 90% of participants stayed for >1 year. The LS stage test showed that 60.7% of the participants were stage 3, 21.4% were stage 2, 14.3% were stage 1, and 3.6% had no risk. The results of the LS stage indicated significant correlations with age, length of stay, and the Barthel Index scores. CONCLUSIONS: Patients who stay in a psychiatric care unit for a long period experience declining physical function, which is associated with aging and long-term hospitalization and might affect their activities of daily living.

DOI： 10.1016/j.jos.2021.01.015

連載創刊40周年記念特別企画オンライン座談会｢整形外科学×『関節外科』40年の歩み｣

帖佐悦男, 筒井廣明, 吉矢晋一

関節外科　基礎と臨床 40 ( 4 ) 467 - 470 2021.4

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000000593

特集骨粗鬆症-指導に役立つエビデンス骨粗鬆症のインパクト

帖佐悦男

総合リハビリテーション 49 ( 4 ) 333 - 337 2021.4

Publishing type：Research paper (scientific journal) Publisher：株式会社医学書院

DOI： 10.11477/mf.1552202193

Predictors of Spondylolysis on Magnetic Resonance Imaging in Adolescent Athletes With Low Back Pain

Takuji Yokoe, Takuya Tajima, Hiroshi Sugimura, Shinichirou Kubo, Shotarou Nozaki, Nami Yamaguchi, Yudai Morita, Etsuo Chosa

Orthopaedic Journal of Sports Medicine 9 ( 4 ) 2021.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1177/2325967121995466

特集整形外科疾患の運動療法-最近の進歩ロコモティブシンドロームに対する運動療法

帖佐悦男

整形･災害外科 64 ( 4 ) 443 - 449 2021.4

Publishing type：Research paper (scientific journal) Publisher：金原出版

DOI： 10.18888/se.0000001683

The impact of helicopter emergency medical services and craniocervical traction on the early reduction of cervical spine dislocation in a rural area of Japan

Lee D., Kawano K., Ishida S., Yamaguchi Y., Kuroki T., Nagai T., Higa K., Kurogi S., Hamanaka H., Ochiai H., Chosa E.

Journal of Orthopaedic Science 27 ( 3 ) 606 - 613 2021.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

Background: Several studies have shown an association between achieving decompression of the spinal cord within a few hours and neurological recovery, even in patients with complete paralysis due to cervical spine dislocation. This study aimed to clarify the impact of helicopter emergency medical services (HEMSs) and craniocervical traction on the rapid reduction of lower cervical spine dislocation in rural Japan. Methods: The success rate of and factors inhibiting closed reduction, the time from injury to reduction and the functional prognosis of lower cervical spine dislocations treated between July 2012 and February 2020 were retrospectively analysed. Results: Fourteen patients were transported by HEMS (group H), seven by ambulance (group A) and two by themselves. Although the average traveled distance and injury severity score were significantly higher in group H (64.5 km, 28.0) than in group A (24.7 km, 18.6), there was no significant difference in the average time to admission or the time to initiation of craniocervical traction after admission between groups H (159.4 min, 52.2 min) and A (163.6 min, 53.2 min). The success rate of closed reduction was 95%, and neurological deterioration was not observed in any cases. The average traction time and weight for reduction were 30.3 min and 16.3 kg, respectively. Body size and fracture-dislocation type did not significantly affect the traction time or weight. The rate of reduction within 4 h after injury was higher in group H (79%) than in group A (33%). Inner fixations were treated an average of 5.7 days after admission. After treatment, three of nine AIS A patients recovered the ability to walk, and all three patients underwent successful closed reduction within 4 h after injury. Conclusion: HEMS and highly successful closed reduction contributed to the early reduction of cervical spine dislocation and can potentially improve complete paralysis.

DOI： 10.1016/j.jos.2021.03.008

Brown-Sequard型麻痺を呈した脊髄ヘルニアの一例

松本尊行, 濱中秀昭, 黒木修司, 比嘉聖, 永井琢哉, 李徳哲, 黒木智文, 帖佐悦男

整形外科と災害外科 70 ( 2 ) 195 - 198 2021.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

脊髄ヘルニアは稀な疾患であり，Brown-Sequard型麻痺を呈し手術加療で軽快した1例を経験したため文献的考察を加え報告する．【症例】59歳，女性【現病歴】来院19年前から左下肢の疼痛と痺れを自覚，徐々に症状増悪したため近医を受診した．MRIにてTh2/3に脊髄ヘルニアを疑う所見を認め手術加療目的で当科紹介となった．【身体所見】下肢MMTは3/5と右下肢で低下，痛覚は左Th7以下で5/10でありBrown-Sequard型麻痺を認めた．【MRI】Th2/3レベルで脊髄の腹側への偏位と右前方への脱出がみられた．【経過】脊髄ヘルニアの診断で，麻痺が進行するため手術加療の方針とした．手術は脊椎後方アプローチにて，硬膜を切開し腹側ヘルニア孔を確認，歯状靭帯を牽引しながらヘルニアを解除した．その後脱出孔を拡大し再度陥頓しないことを確認した．術後下肢筋力は改善，痛覚は左Th7以下で9/10と筋力，感覚ともに改善，MRIでもヘルニアの再発も認められなかった．

DOI： 10.5035/nishiseisai.70.195

Clinical results of vertebral fracture related to diffuse idiopathic skeletal hyperostosis (DISH) which underwent conservative treatment: Three case reports

Kuroki H., Higa K., Chosa E.

International Journal of Spine Surgery 15 ( 1 ) 195 - 202 2021.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：International Journal of Spine Surgery

Background: A vertebral fracture in a patient with diffuse idiopathic skeletal hyperostosis (DISH) is unstable due to larger moment via the long lever arm of an ankylosed spine. Therefore, surgical treatment is commonly recommended to avoid complications of nonunion and paralysis. In this report, we present 3 cases of vertebral fractures related to DISH which were primarily forced to undertake conservative treatment because of medical comorbidities and advanced age. Case 1: A 93-year-old woman suffered from T10 vertebral fracture by a ground-level fall on her back. A trunk cast for 6 weeks was followed by brace wear for 3 months with administration of daily teriparatide. Then complete bone union was confirmed at 2 years after injury without back pain. Case 2: An 84-year-old man suffered from T12 vertebral fracture by a fall on his back from a chair. A trunk cast for 12 weeks was followed by brace wear for 6 months with administration of daily teriparatide. Then acceptable bone union was confirmed at 1 year after the injury, and activities of daily living became independent. Case 3: An 87-year-old woman suffered from T10 vertebral fracture due to a ground-level fall on her back when doing pruning work. Conservative treatment by trunk cast was first initiated with administration of daily teriparatide. However, delayed paralysis developed at 2 weeks after casting, so minimally invasive spinal stabilization (MISt) was performed. Bone union was obtained at 1 year after the injury without any neurological impairment. Conclusions: Favorable clinical courses have been obtained in 2 cases, whereas MISt was required for delayed paralysis in 1 case. Although surgical stabilization is the first-line treatment for vertebral fracture with DISH, conservative treatment can also be one of the options in cases with high operative risk due to serious medical comorbidities. However, during conservative treatment, cautious observation is necessary not to overlook the occurrence of paralysis.

DOI： 10.14444/8025

Evaluation of cervical ossification of the posterior longitudinal ligament with 3D broadband IR-prepared ultrashort echo-time imaging: a pilot study.

Azuma M, Khant ZA, Yoneyama M, Ikushima I, Hamanaka H, Yokogami K, Chosa E, Takeshima H, Hirai T

Japanese journal of radiology 2021.1

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s11604-020-01081-6

Orthopaedic medical examination for young amateur athletes: a repeated cross-sectional study from 2014 to 2018

Yokoe T., Tajima T., Yamaguchi N., Nagasawa M., Ota T., Morita Y., Chosa E.

BMJ Open 11 ( 1 ) e042188 2021.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：BMJ Open

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objectives Medical examinations for adult elite athletes are performed all over the world, however, no studies in the relevant English literature have reported on orthopaedic medical examinations for young amateur athletes. The purpose of this study was to report the results of orthopaedic medical examinations of the spine and lower extremities in young amateur athletes. Methods This repeated cross-sectional study from 2014 to 2018 included a total of 323 young amateur athletes (age, 12-18 years) who were active in one of the following four sports: boxing, canoeing, weightlifting and track and field. The orthopaedic medical examination consisted of six assessments (physical examinations, the generalised joint laxity, muscle and joint tightness, static alignment and muscle volume of the lower extremities and the medial longitudinal arch of the foot). Questions regarding pain in the spine and lower extremities were also performed. Results Among 323 young amateur athletes, 17 (5.3%) had received orthopaedic treatment at the time of the medical examination, with spondylolysis being the most common cause (29.4%, 5/17). Among 306 young athletes who had not received orthopaedic treatment, 61 (19.9%) had at least one positive finding in physical examinations or had pain in the spine or lower extremities. Anterior drawer test of the ankle and Kemp test for the spine accounted for 34% and 28% of positive findings, respectively. Low back pain and knee pain accounted for 58% and 16% of pain, respectively. Conclusions The present study showed that approximately one-fifth of young amateur athletes who had not received orthopaedic treatment had pain in the spine and lower extremities and positive findings in physical examinations that may require orthopaedic treatments. In addition to the early detection of injuries, orthopaedic medical examinations for young amateur athletes provide an opportunity to educate such athletes.

DOI： 10.1136/bmjopen-2020-042188

Significance of Physical Activities and Sports for Children

Chosa Etsuo

Japanese Journal of Orthopaedic Sports Medicine 41 ( 3 ) 126 - 131 2021

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Orthopaedic Socety for Sports Medicine

DOI： 10.34473/jossm.41.3_126

Biomechanical evaluation of artificial hip joint stem with Young's modulus gradation

NAKAI Ryosuke, OCHIAI Kiyohide, WASA Motoki, HANADA Shuji, CHOSA Etsuo, YAMAKO Go

The Proceedings of Conference of Kyushu Branch 74 ( 0 ) C52 2021

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers

DOI： 10.1299/jsmekyushu.2021.74.C52

Predictors of Spondylolysis on Magnetic Resonance Imaging in Adolescent Athletes With Low Back Pain

Yokoe T., Tajima T., Sugimura H., Kubo S., Nozaki S., Yamaguchi N., Morita Y., Chosa E.

Orthopaedic Journal of Sports Medicine 9 ( 4 ) 2325967121995466 2021

Language：English Publishing type：Research paper (scientific journal) Publisher：Orthopaedic Journal of Sports Medicine

Background: Spondylolysis and undiagnosed mechanical low back pain (UMLBP) are the main causes of low back pain (LBP) in adolescent athletes. No studies have evaluated the difference in clinical and radiographic factors between these 2 conditions. Furthermore, it remains unclear which adolescent athletes with LBP should undergo advanced imaging examination for spondylolysis. Purpose: To compare the clinical and radiographic factors of adolescent athletes with spondylolysis and UMLBP who did not have neurological symptoms or findings before magnetic resonance imaging (MRI) evaluation and to determine the predictors of spondylolysis findings on MRI. Study Design: Cohort study, Level of evidence, 3. Methods: The study population included 122 adolescent athletes aged 11 to 18 years who had LBP without neurological symptoms or findings and who underwent MRI. Of these participants, 75 were ultimately diagnosed with spondylolysis, and 47 were diagnosed with UMLBP. Clinical factors and the following radiographic parameters were compared between the 2 groups: spina bifida occulta, lumbar lordosis (LL) angle, and the ratio of the interfacet distance of L1 to that of L5 (L1:L5 ratio, %). A logistic regression analysis was performed to evaluate independent predictors of spondylolysis on MRI scans. Results: Significantly more athletes with spondylolysis were male (82.7% vs 48.9%; P <.001), had a greater LL angle (22.8° ± 8.1° vs 19.3° ± 8.5°; P =.02), and had a higher L1:L5 ratio (67.4% ± 6.3% vs 63.4% ± 6.6%; P =.001) versus athletes with UMLBP. A multivariate analysis revealed that male sex (odds ratio [OR], 4.66; P <.001) and an L1:L5 ratio of >65% (OR, 3.48; P =.003) were independent predictors of positive findings of spondylolysis on MRI scans. Conclusion: The study findings indicated that sex and the L1:L5 ratio are important indicators for whether to perform MRI as an advanced imaging examination for adolescent athletes with LBP who have no neurological symptoms and findings.

DOI： 10.1177/2325967121995466

Efficacy of Diagnosing Carpal Tunnel Syndrome Using the Median Nerve Stenosis Rate Measured on Ultrasonographic Sagittal Imagery: Clinical Case-Control Study

Okura T., Sekimoto T., Matsuoka T., Fukuda H., Hamada H., Tajima T., Chosa E.

Hand 18 ( 1_suppl ) 15589447211017225 - 138S 2021

Language：English Publishing type：Research paper (scientific journal) Publisher：Hand

Background: The purpose of the present study was to evaluate the usefulness of the median nerve stenosis rate (MNSR) measured on sagittal sonographic images of the median nerve in the diagnosis of carpal tunnel syndrome (CTS). Methods: The study population consisted of 45 hands from 37 patients with idiopathic CTS (CTS group), and 60 hands from 35 asymptomatic healthy subjects (control group). Carpal tunnel syndrome was diagnosed by clinical findings and positive electrophysiological study results. All patients and control subjects underwent ultrasonographic examination. At the carpal tunnel level, the transducer was placed longitudinally to the median nerve, and an image of the longitudinal median nerve was obtained. The minimum median nerve diameter (MND) was measured at the middle part of the capitate level, while the maximum MND was measured at the distal radioulnar joint level. The MNSR was calculated as (1 – minimum MND/maximum MND) × 100 (%). The cross-sectional area of the median nerve was also measured at the level of the pisiform. Results: On longitudinal sonographic images, the MNSR was significantly larger in the CTS group than the control group. When the cut-off value of the MNSR was 26.73%, the sensitivity and specificity were 91.1% and 80%, respectively. The area under the receiver operating characteristic curve was larger for the MNSR than for the cross-sectional area. Conclusion: The results suggest that the MNSR proposed in the present study may be useful as an auxiliary method for CTS diagnosis on ultrasonographic examination.

DOI： 10.1177/15589447211017225

Effect of total hip arthroplasty on improving locomotive syndrome in hip disease patients: A prospective cohort study focused on total clinical decision limits stage 3

Miyazaki S., Tsuruta K., Yoshinaga S., Yamaguchi Y., Fujii Y., Arakawa H., Ochiai M., Kawaguchi T., Unoki A., Sakamoto T., Tajima T., Nakamura Y., Funamoto T., Hiyoshi M., Chosa E.

Journal of Orthopaedic Science 27 ( 2 ) 408 - 413 2021

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

Background: In 2020, the Japanese Orthopaedic Association established a new stage 3 in clinical decision limits (CDL) to evaluate the stage of locomotive syndrome (LS). This study focused on total CDL stage 3 with the aim of investigating indicators related to improvements in total CDL by evaluating the improvement of LS in patients who underwent total hip arthroplasty (THA). Methods: Of the 125 patients who underwent THA at our hospital, the subjects of the analysis were 105 patients determined to be total CDL stage 3 in an evaluation performed before THA. LS was evaluated using the stand-up test, two-step test, and 25-Question Geriatric Locomotive Function Scale (GLFS-25). Indicators related to improvements in total CDL were also investigated. All evaluation items were measured before THA and three months after THA. Results: Before THA, all subjects (n = 105) were classified as total CDL stage 3. Three months after THA, improvements in total CDL were seen in 49 subjects (46.7%). The results of stepwise multiple logistic regression analysis showed that the before THA stand-up test and GLFS-25 were significantly related to improvements in total CDL. Conclusions: Three months after THA, improvements in LS were seen in approximately half of the subjects. The stand-up test and GLFS-25 can be used as indicators of improvement in total CDL. Design: Prospective cohort study design.

DOI： 10.1016/j.jos.2020.12.028

The Ratio of Stress to Nonstress Anterior Talofibular Ligament Length on Ultrasonography: Normative Values

Yokoe T., Tajima T., Kawagoe S., Yamaguchi N., Morita Y., Chosa E.

Orthopaedic Journal of Sports Medicine 9 ( 11 ) 23259671211056305 2021

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Orthopaedic Journal of Sports Medicine

Background: Stress ultrasonography (US) has been shown to be a valid procedure for evaluating chronic anterior talofibular ligament (ATFL) injury. The ratio of stress/nonstress ATFL length (ATFL ratio) as measured on US is clinically useful; however, there are no published normative data concerning this ratio. Purpose: To report a normative value of the ATFL ratio on US and evaluate the relationships between sex, generalized joint laxity (GJL), and the grade of anterior drawer test (ADT). Study Design: Cross-sectional study; Level of evidence, 3. Methods: The ATFL lengths were prospectively measured in the stress and nonstress positions (manual maximal anterior drawer position) for participants with noninjured ankles from March 2020 to March 2021. GJL was defined as a Beighton score ≥4. A manual ADT was also performed. The ATFL ratio was calculated, and the relationships between sex, GJL, and ADT grade were evaluated. Results: A total of 333 ankles in 184 participants (mean age, 24.5 ± 2.7 years; range, 20-33 years) were eligible for the analysis. GJL was found in 69 ankles (20.7%). The mean ATFL ratio was 1.08 ± 0.04 (95% CI, 1.08-1.09; range, 1.01-1.24), and there was a significant difference between male (1.07 ± 0.04; 95% CI, 1.07-1.08; range, 1.02-1.23) and female (1.09 ± 0.04; 95% CI, 1.08-1.10; range, 1.01-1.24) ankles (P =.001). In male ankles, the ATFL ratio was significantly greater in participants with GJL (1.11 ± 0.06 vs 1.07 ± 0.03; P =.02) or a higher grade of ADT (grade 2 vs grade 1: 1.11 ± 0.06 vs 1.07 ± 0.03, P =.002). These findings were not observed in female ankles. Conclusion: The normative value of the ATFL ratio on stress US was 1.07 ± 0.04 in men and 1.09 ± 0.04 in women. The ATFL ratio was affected by the presence of GJL in men but not in women. These findings will be useful for future studies seeking to establish the cutoff value of the ATFL ratio for diagnosing chronic lateral ankle stability on stress US.

DOI： 10.1177/23259671211056305

原発性骨粗鬆症に対するロモソズマブの実臨床成績の検討 Reviewed

帖佐悦男

日本骨粗鬆症学会雑誌 8 31 - 42 2021

Publishing type：Research paper (scientific journal)

手関節疼痛のある関節リウマチ患者における脱着式保温素材を用いたリストサポーター装着時の即時効果に関する検討 Reviewed

帖佐悦男

日本ハンドセラピィ学会誌 13 107 - 110 2021

Publishing type：Research paper (scientific journal)

Spectator medicine at an international mega sports event: Rugby World Cup 2019 in Japan Reviewed

Tajima T., Takazawa Y., Yamada M., Moriya T., Sato H., Higashihara J., Toyama Y., Chosa E., Nakamura A., Kono I.

Environmental Health and Preventive Medicine 25 ( 1 ) 72 2020.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Environmental Health and Preventive Medicine

© 2020, The Author(s). Background: The Rugby World Cup (RWC) is one of the biggest international mega sports events in the world. This study was conducted to identify and evaluate the volume, nature, and severity of spectator medical care in the stadiums of 12 venues across Japan during RWC 2019. Method: This was a retrospective review of medical records from spectator medical rooms of 45 official matches of RWC 2019 between September 20 and November 2, 2019. All patients in the stadium who visited the spectator medical room and were transferred to a hospital were included. The wet bulb globe temperature (WBGT) value at the kick-off time of each match, the number of visits to the spectator medical room, and the number of transfers to a hospital were reviewed and analyzed. The patient presentation rate (PPR) was calculated per 10,000 attendees. Severity categories were defined as mild or severe. Mild cases were considered non-life threatening requiring minimal medical intervention, and severe cases required transport to a hospital. Result: The total number of visits to the spectator medical room was 449 with a PPR of 2.63. Most cases (91.5%) were mild in severity. The PPR was significantly higher for the matches held with a WBGT over 25 °C than for the matches under 21 °C (PPR 4.27 vs 2.04, p = 0.04). Thirty-eight cases were transferred to a hospital by ambulance; the PPR was 0.22. The most common reasons for transfer to the hospital were heat illness and fracture/dislocation, at a rate of 15.8% each. The incidence rate of cardiopulmonary arrest per 10,000 attendees was 0.0059 during RWC 2019. Conclusion: Preparation and provision of appropriate medical service for spectators is a key factor for mass-gathering events. During RWC 2019, the majority (91.5%) of patients who sought medical attention did so for minor complaints, which were easily assessed and managed. On the other hand, a higher WBGT situation contributes significantly to an increased PPR (< 21 versus > 25, 2.04 versus 4.27, p = 0.04). Careful medical preparation, management, and development of public education programs for higher WBGT situations will be required in the future for similar international mega sports events.

DOI： 10.1186/s12199-020-00914-0

特集関節鏡(内視鏡)のエキスパートを目指そう introduction

帖佐悦男

関節外科　基礎と臨床 39 ( 11 ) 1161 - 1161 2020.11

Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社

DOI： 10.18885/jjs.0000000450

特集アキレス腱断裂診療のコツと最近のトピックスアキレス腱断裂の診断

田島卓也, 帖佐悦男

整形･災害外科 63 ( 12 ) 1627 - 1635 2020.11

Publishing type：Research paper (scientific journal) Publisher：金原出版

DOI： 10.18888/se.0000001518

Analysis of Suitable Cervical Spine Alignment and Muscle Strength Around The Neck of Collision Sports Players – To Prevent The Severe Head and Neck Injuries

Tajima Takuya, Yamaguchi Nami, Kuroki Syuji, Morita Yudai, Chosa Etsuo

DESCENTE SPORTS SCIENCE 41 ( 0 ) 135 - 144 2020.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION OF SPORTS SCIENCE

Severe head and neck injuries occasionally occur in collision sports such as Judo or Rugby football. Degenerative changes in the cervical spine including abnormal alignment, spur formation and disc space narrowing are risk factors for severe injuries. It is also well known that neck muscle strength is one of the important factors for the prevention of severe injuries and degenerative disorders. The aim of this study future was to assess the relationship between the neck muscle strength and radiographic findings of the cervical spine among collision sports players. We hypothesized that poor muscle strength and unbalanced neck muscle flexion/extension strength ratio maybe associated with degenerative cervical findings. 168 judo-players （22-32 years old） and 203 rugby football-players （18-30） underwent neck extension and flexion muscle strength measurement, and 55 judo-players and 58 rugby players underwent cervical radiographical examination. Cervical alignment was classified as normal, straight, kyphosis, and sigmoid according to the Borden & Rechitman method. Disc space narrowing and spur formation were also measured according to the Kondo method and the Nathan classification. Height, weight, neck flexion and extension strength, flexion/extension ratio of the judo group ware higher than that of the rugby group with stastical significance. However, there were no significant difference of result/weight value （Judo: flexion;2.39N, extension;3.38N. ratio;0.71, Rugby: flexion;2.37, extension; 3.41, ratio; 0.70）．In Judo group, sigmoid deformity group （420±50.2N） showed significantly higher neck extension strength compared with normal group （331.7±48.4N, p<0.05）．At the factor of flexion/extension muscle strength ratio, straight （0.67） and kyphosis （0.63） group showed significantly lower value compared with normal group （0.78. p<0.05） in Judo. In Rugby group, the presence of spur formation group （0.54） showed lesser flexion/extension muscle strength ratio compared with normal group （0.68）， significantly （p<0.05）．Neck muscle strength is one important factor to prevent and reduce the severe neck injury or cervical spine abnormal findings. From this study, not only the value of muscle strength, but also the flexion/extension ratio provide important contribution for these findings. Lower flexion/extension neck muscle strength ratio is one of the risk factors of cervical spine issues for collision sports players.

DOI： 10.57488/descente.41.0_135

Comparison of symptomatic spondylolysis in young soccer and baseball players Reviewed

Yokoe T., Tajima T., Sugimura H., Kubo S., Nozaki S., Yamaguchi N., Morita Y., Chosa E.

Journal of Orthopaedic Surgery and Research 15 ( 1 ) 378 2020.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Surgery and Research

© 2020 The Author(s). Background: Spondylolysis is the main cause of low back pain (LBP) in young athletes. There are few studies analyzing the difference of spondylolysis among young athletes with different sports activities. The purpose of this study was to compare the clinical factors and distribution of the lesions of spondylolysis on magnetic resonance imaging (MRI) scans in young soccer and baseball players with symptomatic spondylolysis. Methods: The medical records of 267 young athletes aged 7 to 18 years old who underwent MRI to evaluate the cause of LBP between 2017 and 2020 were retrospectively reviewed to identify patients with spondylolysis. Of the young athletes with symptomatic spondylolysis, clinical factors and MRI findings in soccer and baseball players were retrospectively evaluated. The clinical factors were age, sex, interval from onset of LBP to MRI, and side of the dominant leg in the sports field. MRI findings included number, lumbar level, and side of the lesions. Results: A total of 33 soccer players (mean age, 15.4 ± 1.4 years) and 49 baseball players (mean age, 15.4 ± 1.6 years) with symptomatic spondylolysis were enrolled. All patients were male. No significant differences were noted in age and the interval from onset of LBP to MRI between the groups. Soccer players had greater numbers of multiple (p < 0.001) and bilateral (p < 0.001) lesions than baseball players. The dominant side of the hand for pitching or batting was correlated with the contralateral-side lesions in baseball players (p = 0.001). Conclusions: The distribution of the lesions of spondylolysis differed in young soccer and baseball players. Pitching or batting with the dominant-side hand would be associated with contralateral-side lesions in baseball players. Sports-specific movements and the side of the dominant leg should be considered when treating young athletes with symptomatic spondylolysis.

DOI： 10.1186/s13018-020-01910-4

Googling musculoskeletal-related pain and ranking of medical associations' patient information pages: Google ads keyword planner analysis Reviewed

Yamaguchi Y., Lee D., Nagai T., Funamoto T., Tajima T., Chosa E.

Journal of Medical Internet Research 22 ( 8 ) e18684 2020.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Medical Internet Research

© 2020 Journal of Medical Internet Research. All rights reserved. Background: Most people currently use the internet to obtain information about many subjects, including health information. Thus, medical associations need to provide accurate medical information websites. Although medical associations have their own patient education pages, it is not clear if these websites actually show up in search results. Objective: The aim of this study was to evaluate how well medical associations function as online information providers by searching for information about musculoskeletal-related pain online and determining the ranking of the websites of medical associations. Methods: We conducted a Google search for frequently searched keywords. Keywords were extracted using Google Ads Keyword Planner associated with "pain" relevant to the musculoskeletal system from June 2016 to December 2019. The top 20 search queries were extracted and searched using the Google search engine in Japan and the United States. Results: The number of suggested queries for "pain" provided by Google Ads Keyword Planner was 930 in the United States and 2400 in Japan. Among the top 20 musculoskeletal-related pain queries chosen, the probability that the medical associations' websites would appear in the top 10 results was 30% in the United States and 45% in Japan. In five queries each, the associations' websites did not appear among the top 100 results. No significant difference was found in the rank of the associations' website search results (P=.28). Conclusions: To provide accurate medical information to patients, it is essential to undertake effective measures for search engine optimization. For orthopedic associations, it is necessary that their websites should appear among the top search results.

DOI： 10.2196/18684

Tajima T, Yamaguchi N, Morita Y, Nagasawa M, Ota T, Nakamura Y, Yokoe T, Chosa E

The journal of knee surgery 34 ( 14 ) 1545 - 1554 2020.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Knee Surgery

For anterior cruciate ligament (ACL)-deficient patients, using a single bone-patellar tendon-bone (BPTB) graft for the double-bundle concept is one of the suitable approaches for acquiring better stability and reducing bone tunnel enlargement compared with the use of hamstring grafts. At least 10-mm width of BPTB autograft is needed to achieve this concept; however, it is larger than one-third of the patellar tendon width for small or middle physique patients. This study aimed to assess the clinical and radiographic outcomes of BPTB and gracilis (G) composite autografts for primary double-bundle ACL reconstruction in Asian athletes. Thirty-two Asian patients undergoing double-bundle ACL reconstruction with 7.0 to 7.5 mm of BPTB and 5.0 to 5.5 mm of G composite grafts were compared with 43 double-bundle ACL reconstruction with hamstring graft cases. The BPTB graft was used for the anteromedial bundle (AMB), with the G graft for the posterolateral bundle (PLB). Percentage of femoral bone tunnel enlargement compared with the original size was determined by computed digital radiographs on the first postoperative day and at 12 months in the anteroposterior (AP) and lateral views. Standard clinical evaluations, including the limb symmetry index (LSI), were also performed. Less PLB tunnel enlargement was found in the BPTB + G group than in the hamstring group in the AP (101.9 ± 22.9 vs.113.7 ± 20.6%, p = 0.031) and lateral views (104.4 ± 18.1 vs. 120.6 ± 23.4%, p < 0.01).There was no significant difference between the groups in 12-month postoperative clinical outcomes (Lysholm's score, Tegner's activity level scale, and International Knee Documentation Committee subjective knee evaluation score).The side-to-side difference was significantly less in the BPTB + G group (0.2 ± 1.3 vs. 0.9 ± 1.1 mm, p = 0.026). Despite the small sizes of the BPTB and G grafts, there was no significant difference in the knee extensor LSI between the groups (92.9 ± 10.1 vs. 93.3 ± 12.2%, p = 0.707), whereas the knee flexor LSI was significantly higher in the BPTB + G group (97.7 ± 14.8 vs. 90.1 ± 13.3%, p = 0.033). Double-bundle ACL reconstruction with a small size BPTB and G composite graft procedure provided good clinical outcomes and significantly less femoral bone tunnel enlargement than the hamstring procedure 12 months after surgery. It is thus a useful surgical option for ACL-deficient Asian athletes. This study reflects level of evidence III.

DOI： 10.1055/s-0040-1710376

TKA術後CT評価によるPatient-Specific Instrumentationの正確性と術後成績 Reviewed

小島岳史、久保紳一郎、田島直也、野崎正太郎、三橋龍馬、三股奈津子、関本朝久、帖佐悦男

整形外科と災害外科 69 ( 2 ) 229 - 232 2020.3

Language：Japanese Publishing type：Research paper (scientific journal)

膝複合靱帯再建術にACL補強術を採用した小経験 Reviewed

田島卓也、山口奈美、大田智美、長澤誠、森田雄大、帖佐悦男

JOSKAS 45 ( 1 ) 74 - 75 2020.3

Language：Japanese Publishing type：Research paper (scientific journal)

当院の難治性創傷に対するNPWTの経験

小牧亘、深野木快士、外山貴彬、仲原ちづ子、濱田浩朗、帖佐悦男

宮崎整形外科研究会誌 ( 24 ) 4 - 6 2020.3

Language：Japanese Publishing type：Research paper (scientific journal)

頚椎神経障害性上肢痛と肩関節由来疼痛の鑑別

李徳哲、永井琢哉、川野啓介、比嘉聖、黒木修司、濱中秀昭、帖佐悦男

宮崎整形外科研究会誌 ( 24 ) 63 - 65 2020.3

Language：Japanese Publishing type：Research paper (scientific journal)

非定型大腿骨骨折のリスク因子の検討-当院独自のAFFリスク判定法を用いて-

小牧亘、深野木快士、太田尾祐史、福富雅子、李徳哲、濱田浩朗、帖佐悦男

宮崎整形外科研究会誌 ( 24 ) 60 - 62 2020.3

Language：Japanese Publishing type：Research paper (scientific journal)

寛骨臼骨折に対し急性期に一期的人工股関節置換術を施行した2症例

川越悠輔、帖佐悦男、坂本武郎、池尻洋史、中村嘉宏、舩元太郎、日吉優、川野啓介

宮崎整形外科研究会誌 ( 24 ) 9 - 11 2020.3

Language：Japanese Publishing type：Research paper (scientific journal)

特集知っていますか?小児科領域のスポーツ障害スポーツ関連トピックス　新たに開始された運動器検診の成績と課題　平成28(2016)年度以前との比較を含め

帖佐悦男

小児科診療 83 ( 2 ) 223 - 229 2020.2

Publishing type：Research paper (scientific journal) Publisher：(株)診断と治療社

DOI： 10.34433/j00642.2020136309

Correlation between playing position, elbow physical findings and elbow pain in elementary school baseball players: Results of a multi-regional study in Japan Reviewed

Surgical Wound Complications after Knee Cruciate Ligament Reconstruction in Patients with Atopic Dermatitis Reviewed

Yokoe T,Tajima T,Yamaguchi N,Morita Y,Chosa E

The Journal of Knee Surgery 2020.1

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1055/s-0040-1702186

Matsuura T., Chosa E., Tajika T., Masatomi T., Arimitsu S., Yamamoto A., Nagasawa M., Arisawa K., Takagishi K.

Journal of Orthopaedic Science 25 ( 1 ) 122 - 126 2020.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

© 2019 Background: Elbow injuries are common in young baseball players and evaluating the characteristics of young baseball players in a large-scale population is necessary. However, few studies have compared playing position, length of baseball experience, physical findings, and elbow pain in young baseball players. This retrospective multi-regional cohort study sought to document the physical findings at the elbow in Japanese elementary school baseball players and to examine the relationship between playing position, length of baseball experience, physical findings at the elbow, and elbow pain. Methods: In 2014, 720 fifth-grade baseball players from four regions in Japan were invited to participate in a questionnaire survey and undergo physical examination to obtain data on position played, length of baseball experience, presence of elbow pain, and physical findings at the elbow, including range of motion, tenderness, and valgus stress test results. Potential risk factors associated with elbow pain and correlations between physical findings and playing position, length of baseball experience, and elbow pain were investigated. Results: The 720 subjects had a mean age of 10.4 years and 29.4% reported having experienced elbow pain for ≥1 week. Risk factors for elbow pain included playing pitcher and catcher, playing pitcher and fielder, and length of baseball experience. The most frequent finding was limitation of flexion (21.1%) followed by tenderness of the medial epicondyle (18.3%) and a positive valgus stress test (14.3%). These three findings were also significantly associated with elbow pain. Elbow extension was limited in 14.9% of subjects but there was no correlation with length of baseball experience or elbow pain. Conclusions: Our data show that elementary school baseball players who experienced elbow pain are likely to have valgus stress overload. Elbow pain might be prevented by not playing pitcher and catcher.

DOI： 10.1016/j.jos.2019.02.020

デノスマブ投与後の骨巨細胞腫の1例

大栗伸行、山下篤、坂本武郎、帖佐悦男、浅田祐士郎、佐藤勇一郎

診断病理 37 ( 1 ) 15 - 19 2020.1

Language：Japanese Publishing type：Research paper (scientific journal)

The Mission of National Team Doctor for Providing Best Performance of Players

Tajima Takuya, Nakamura Akihiko, Chosa Etsuo

Japanese Journal of Orthopaedic Sports Medicine 40 ( 3 ) 229 - 235 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Orthopaedic Socety for Sports Medicine

DOI： 10.34473/jossm.40.3_229

TKA術後CT評価によるPatient-Specific Instrumentationの正確性と術後成績

小島岳史, 久保紳一郎, 田島直也, 野崎正太郎, 三橋龍馬, 三股奈津子, 関本朝久, 帖佐悦男

整形外科と災害外科 69 ( 2 ) 229 - 232 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【はじめに】我々は2016年4月よりPatient Specific Instrumentaion（PSI）を使用しTKAを施行している．その正確性をCTにて解析した．【対象】2016年4月から2018年8月までにPSIを使用したTKAを施行した34例40膝中，術後CTによる評価を行えた15例16膝．手術時平均年齢は69.9歳，原因疾患は全例内側型変形性膝関節症であった．【方法】術前後に全下肢CTを撮影．bone matching法で術前計画との誤差を測定し，目標設置角度より3°以上の誤差をoutlierとし評価した．術後成績はJOA scoreにて評価した．【結果】平均手術時間は104分，大腿骨側の内外反設置角度の正確性は0°±2.4°，outlier 19％（3/16），脛骨内外反設置角度0.8°±2.5°，outlier 38％（6/16），脛骨後傾設置角度1.3°±3.5°，outlier 50％（8/16）であった．JOA scoreは術前58.1±6.8点から術後80.3±7.2点に有意に改善した．【考察】大腿骨・脛骨側内外反・後傾ともに高率にoutlierを認めた．cutting block設置や特有のボーンソー使用法に関してlearning curveの存在があると考える．

DOI： 10.5035/nishiseisai.69.229

Reference values for the locomotive syndrome risk test quantifying mobility of 8681 adults aged 20–89 years: A cross-sectional nationwide study in Japan

Keiko Yamada, Yoichi M. Ito, Masao Akagi, Etsuo Chosa, Takeshi Fuji, Kenichi Hirano, Shinichi Ikeda, Hideaki Ishibashi, Yasuyuki Ishibashi, Muneaki Ishijima, Eiji Itoi, Norimasa Iwasaki, Ryoichi Izumida, Ken Kadoya, Masayuki Kamimura, Arihiko Kanaji, Hiroyuki Kato, Shunji Kishida, Naohiko Mashima, Shuichi Matsuda, Yasumoto Matsui, Toshiki Matsunaga, Naohisa Miyakoshi, Hiroshi Mizuta, Yutaka Nakamura, Ken Nakata, Go Omori, Koji Osuka, Yuji Uchio, Kazuteru Ryu, Nobuyuki Sasaki, Kimihito Sato, Masuo Senda, Akihiro Sudo, Naonobu Takahira, Hiroshi Tsumura, Satoshi Yamaguchi, Noriaki Yamamoto, Kozo Nakamura, Takashi Ohe

Journal of Orthopaedic Science 25 ( 6 ) 1084 - 1092 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.jos.2020.01.011

種子骨が嵌頓し整復阻害因子となった母趾趾節間関節脱臼の陳旧例の1例

今里浩之, 高橋巧, 松本尊行, 森治樹, 帖佐悦男, 坂本武郎, 濱田浩朗, 池尻洋史, 中村嘉宏, 舩元太郎, 日吉優, 山口洋一朗

整形外科と災害外科 69 ( 3 ) 612 - 614 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【はじめに】種子骨の背側陥入を認める母趾趾節間（IP）関節脱臼は稀である．今回4週経過した陳旧性のIP関節脱臼を経験したため，報告する．【症例】40歳男性．28日前，2mの高さから転落し左足をついて受傷．近医にて左母趾の裂創の処置を受けるも，疼痛は改善せず当院受診となった．単純X線にて母趾IP関節の脱臼を認め，CTでIP関節の背側に種子骨を認めた．徒手整復は不可能であった．同日背側アプローチで進入し，背側の種子骨と掌側板を底側に押し込むと脱臼を整復できたが，易脱臼性を認めIP関節固定と背側block pin施行した．術後は6週でPin抜去し，再脱臼なく経過し，最終JSSF score（6か月）は95点であった．【考察】IP関節脱臼で種子骨の背側嵌頓を認める場合，観血的整復が必要であり，本症例でも同様であった．

DOI： 10.5035/nishiseisai.69.612

診断に難渋した特発性硬膜下血腫の一例

川越隆行, 帖佐悦男, 濱中秀昭, 黒木修司, 比嘉聖, 川野啓介, 永井琢哉, 李徳哲, 高橋巧, 濱田浩朗

整形外科と災害外科 69 ( 4 ) 790 - 793 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【はじめに】非常に稀な特発性脊髄硬膜下血腫を経験したので報告する．【症例】78歳女性．突然の背部痛と呼吸困難感が出現し，前医に救急搬送された．MRIで胸椎レベルに脊髄硬膜外血腫を疑う所見があり，徐々に膝立て困難となったため，当院に転院搬送となった．当院初診時MMT4まで改善していたが，その後もMMT2まで動揺する下肢麻痺を認めた．再検MRIでTh4-L2の脊髄腹側に血腫があり，さらにT12/L1のT2高輝度変化を認めた．受傷後2週目の脊髄造影検査で，褐色の髄液を認め，特発性硬膜下血腫と診断した．保存加療にて血腫は自然消退，独歩可能となった．【考察】特発性硬膜下血腫の画像上の特徴はMRIで三日月型とされているが，その他の出血性病変と鑑別困難なこともあり，稀ではあるが脊髄硬膜下血腫を念頭に置いて診療することが必要である．

DOI： 10.5035/nishiseisai.69.790

観血的整復を要した第3・4・5外傷性MTP関節脱臼の1例

福永幹, 坂本武郎, 関本朝久, 濱田浩朗, 帖佐悦男, 今里浩之, 福嶋研人, 横江琢示, 山口洋一朗, 日吉優, 舩元太郎, 中村嘉宏, 池尻洋史

整形外科と災害外科 69 ( 3 ) 609 - 611 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

【はじめに】母趾以外の外傷性Metatarsophalangeal（以下，MTP）関節脱臼は稀とされ，大部分は徒手整復可能であるが不能例も存在する．今回，観血的整復を要したMTP関節脱臼の一例を経験したため報告する．【症例】18歳男性，バイク運転中に軽自動車へ衝突し受傷，当院搬送．Xp，CTにて第3～5趾MTP関節の背側脱臼と第2中足骨頚部骨折を認めた．透視下に徒手整復を施行し，第5趾のみ整復できたが，3～4趾は不能であった．同日，観血的整復へ移行し，第3・4趾間MTP関節に陥頓した関節包，虫様筋を認めた．整復阻害因子と考えられ，背側進入を選択し，陥頓の解除で容易に整復可能であった．4週MTP関節をこえるシーネ固定，踵部荷重を許可し，12週後の観察時，再脱臼は認めていない．【考察】観血的整復を要した第3・4・5外傷性MTP関節脱臼の一例を経験した．徒手整復不能例は速やかに観血的整復への移行が必要である．整復困難であった3・4足趾には関節内に陥頓した関節包及び虫様筋を認め整復阻害因子と思われた．

DOI： 10.5035/nishiseisai.69.609

ロコモティブシンドロームとリハビリテーション医学研究

荒川英樹, 宮崎茂明, 鳥取部光司, 帖佐悦男

The Japanese Journal of Rehabilitation Medicine 57 ( 12 ) 1183 - 1184 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：公益社団法人日本リハビリテーション医学会

DOI： 10.2490/jjrmc.57.1183

Biomechanical Evaluation of Isotropic and Shell-Core Composite Meniscal Implants for Total Meniscus Replacement: A Nonlinear Finite Element Study Reviewed

Shriram D., Yamako G., Chosa E., Subburaj K.

IEEE Access 7 140084 - 140101 2019.9

Language：English Publishing type：Research paper (scientific journal) Publisher：IEEE Access

© 2013 IEEE. Loss of meniscal function due to symptomatic meniscal tears or meniscectomy leads to biomechanical instability and articular cartilage degeneration. Synthetic meniscal implants ought to ideally restore normal joint contact mechanics and thus forfending the overlying cartilage from degeneration. The purpose of this study was to quantify the contact stresses in both tibiofemoral compartments and joint kinematics during a gait cycle after implantation of a synthetic meniscal implant. Anatomically-detailed finite element model of the knee joint was developed from magnetic resonance images of a healthy female volunteer. Gait analysis was conducted using a three-dimensional motion capture system and computed the knee joint forces and moments and quadriceps muscle forces for a complete walking cycle. The effects of a synthetic meniscal implant on joint mechanics during gait were studied by conducting finite element simulations for the following meniscus conditions: (i) intact meniscus, (ii) meniscus with complete radial posterior root tear, (iii) total meniscectomy, (iv) isotropic meniscal implant, and (v) shell-core composite meniscal implant. Posterior root tear and total meniscectomy caused substantially increased contact stresses in both tibiofemoral compartments and altered tibial kinematics. Compared to posterior root tear and total meniscectomy, the isotropic and composite meniscal implants reduced the peak contact stresses in both compartments and reduced the cartilage nodes with higher contact stresses by disseminating the load over a large surface area. The shell-core composite meniscal implant resulted in lower contact stresses in the medial compartment relative to the other meniscus conditions. This study demonstrated that posterior root tear and total meniscectomy leads to detrimental changes in joint mechanics. Superseding the injured meniscus with a synthetic meniscal implant restored the joint mechanics close to the intact meniscal state. This novel synthetic meniscal implantation approach appears to be a promising strategy for treating patients with severe meniscal injuries.

DOI： 10.1109/ACCESS.2019.2943689

Blockade of the angiotensin ll type 1 receptor increases bone mineral density and left ventricular contractility in a mouse model of juvenile Paget disease. Reviewed

脳性麻痺の股関節完全脱臼に対して筋解離術後に外固定を併用して治療を行った5例 Reviewed

梅﨑哲矢,川野彰裕,門内一郎,帖佐悦男

日本小児整形外科学会雑誌 28 ( 1 ) 94 - 98 2019.9

Language：Japanese Publishing type：Research paper (scientific journal)

妊娠後骨粗鬆症により多発椎体骨折をきたした2例 Reviewed

日高三貴、李徳哲、濱中秀昭、黒木修司、比嘉聖、川野啓介、永井琢哉、関本朝久、帖佐悦男

整形外科と災害外科 68 ( 4 ) 656 - 660 2019.9

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.5035/nishiseisai.68.656

Tsuruda T, Funamoto T, Udagawa N, Kurogi S, Nakamichi Y, Koide M, Chosa E, Asada Y, Kitamura K

European Journal of Pharmacology 859 172519 2019.9

Language：English Publishing type：Research paper (scientific journal) Publisher：European Journal of Pharmacology

© 2019 Juvenile Paget disease (JPD1), an autosomal-recessive disorder, is characterized by extremely rapid bone turnover due to osteoprotegerin deficiency. Its extra-skeletal manifestations, such as hypertension and heart failure, suggest a pathogenesis with shared skeletal and cardiovascular system components. In spite of this, the effects of anti-hypertensive drugs on bone morphometry remain unknown. We administered an angiotensin II type 1 receptor blocker, olmesartan (5 mg/kg/day) to 8-week-old male mice lacking the osteoprotegerin gene, with and without 1 μg/kg/min of angiotensin II infusion for 14 days. Olmesartan treatment decreased systolic blood pressure, and echocardiography showed increased left ventricular systolic contractility. Three-dimensional micro-computed tomography scans demonstrated that olmesartan treatment increased trabecular bone volume (sham, +176%; angiotensin II infusion, +335%), mineral density (sham, +150%; angiotensin II infusion, +313%), and trabecular number (sham, +407%; angiotensin II infusion, +622%) in the tibia. Olmesartan increased cortical mineral density (sham, +19%; angiotensin II infusion, +24%), decreased the cortical bone section area (sham, −16%; angiotensin II infusion, −18%), decreased thickness (sham, −18%; angiotensin II infusion, −31%), and decreased the lacunar area (sham, −41%; angiotensin II infusion, −27%) in the tibia. Similar trend was observed in the femur. Moreover, olmesartan decreased angiotensin II-induced increases in tartrate-resistant acid phosphatase concentrations in plasma, but it affected neither type I procollagen N-terminal propeptides, nor the receptor activator of nuclear factor kappa-B ligand. Our data suggest that blockade of the angiotensin II type 1 receptor improves bone vulnerability, and helps to maintain the heart's structural integrity in osteoprotegerin-deficient mice.

DOI： 10.1016/j.ejphar.2019.172519

Elective one-stage all four-ligament reconstruction after open knee dislocation: A case report Reviewed

Yokoe T., Tajima T., Yamaguchi N., Chosa E.

Journal of Orthopaedic Science 27 ( 3 ) 743 - 749 2019.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

DOI： 10.1016/j.jos.2019.08.012

Yoshinaga S, Shiomitsu T, Kamohara M, Fujii Y, Chosa E, Tsuruta K

Journal of Orthopaedic Science 24 ( 6 ) 1105 - 1109 2019.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

© 2019 The Japanese Orthopaedic Association Background: This study aimed to estimate the prevalence of locomotive syndrome (LS) risk in age groups using the LS risk test proposed by the Japanese Orthopaedic Association. Based on this, this study identified the lifestyle-related signs that lead to LS, by clarifying the association between LS risk and lifestyle factors. Methods: A total of 728 individuals aged 20–91 years who were without specific mobility disorders were evaluated. Participants were asked to perform the LS risk test and complete a self-administered original questionnaire survey for this study. The Mann–Whitney U test was used to examine the relationships of sex and age with LS. The prevalence of LS by sex and age was compared using the Chi-squared test or Student's t-test, as appropriate. The Mantel–Haenszel test was used to examine the relationship of each component of the lifestyle factors. Results: Overall, 36.4% of males and 49.1% of females were classified into the LS group; the prevalence of LS was significantly higher in females than males (p < .001). The prevalence of LS tended to increase with age in both males and females (p < .05). As for health condition, pain in the locomotive organs, knees, back, and hip joints was significantly associated with LS (p < .05). Of the lifestyle-related diseases, only hypertension (p < .05) was significantly associated with LS, and drug treatment was significantly associated with LS (p < .05). As for lifestyle, anxiety about physical fitness, self-assessed poor health, irregular dietary habits, and lack of exercise were also associated with LS (p < .05). Conclusions: Interventions to prevent LS are important during its early stages, especially for females, and lifestyle-related signs of LS, such as pain in the locomotive organs, lifestyle-related disease, drug treatment, and a lower subjective evaluation of health must not be overlooked.

DOI： 10.1016/j.jos.2019.08.005

Shoulder and elbow in junior high school baseball players: Results of a nationwide survey. Reviewed

Takagishi K, Matsuura T, Masatomi T, Chosa E, Tajika T, Iwama T, Watanabe M, Otani T, Inagaki K, Ikegami H, Aoki M, Okuwaki T, Kameyama Y, Akira M, Kaneoka K, Sakamoto M, Beppu M

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 24 ( 4 ) 708 - 714 2019.7

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jos.2018.12.018

Early weight-bearing after anterior cruciate ligament reconstruction with hamstring grafts induce femoral bone tunnel enlargement: A prospective clinical and radiographic study Reviewed

上腕骨小頭離断性骨軟骨炎手術例と野球検診の関係 Reviewed

岩佐一真、長澤誠、田島卓也、山口奈美、大田智美、森田雄大、帖佐悦男

九州・山口スポーツ医・科学研究会誌 31 35 - 37 2019.7

Language：Japanese Publishing type：Research paper (scientific journal)

Tajima T., Yamaguchi N., Nagasawa M., Morita Y., Nakamura Y., Chosa E.

BMC Musculoskeletal Disorders 20 ( 1 ) 274 2019.6

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Musculoskeletal Disorders

© 2019 The Author(s). Background: Bone tunnel enlargement following primary anterior cruciate ligament (ACL) reconstruction with soft tissue graft might be a severe disadvantage for revision surgery. The postoperative rehabilitation protocol including the non-weight-bearing periods were different depending on the surgeon or institute. To determine the relationship between femoral bone tunnel enlargement and the postoperative non-weight-bearing period after double-bundle ACL reconstruction with hamstring grafts. Methods: Forty-two patients who underwent primary double-bundle ACL reconstruction with hamstring grafts were divided into two postoperative non-weight-bearing protocol groups: 1-week non-weight-bearing postoperatively (group A, n = 19); and 2-week non-weight-bearing (group B, n = 18). Five cases were excluded due to additional knee injury, pregnancy, and lost to follow-up. Bone tunnel enlargement was evaluated by computed digital radiographs (anteroposterior (A-P) and lateral views) taken on the first postoperative day and at 12 months. Each tunnel diameter was shown as a percentage to the maximum joint width of the proximal tibia in the A-P view, or a percentage of the maximum diameter of the patella in the lateral view. To determine the incidence of tunnel enlargement, percentage diameter changes of more than 10% were defined as an enlarged tunnel. The magnitude of tunnel enlargement and the standard clinical evaluation were also evaluated. Results: There were no significant differences between groups in the incidences of anteromedial and posterolateral bone tunnel enlargement, both in the A-P and lateral views (2 × 2 Chi-squared test). The magnitude of femoral posterolateral bone tunnel enlargement was significantly greater in group A in the A-P view (p = 0.01) and lateral view (p = 0.03) (Mann Whitney U-test). Twelve months after surgery, the Lysholm score and Tegner activity level scale were not significantly different between the groups. Conclusions: This prospective, clinical and radiographical study showed that early weight-bearing protocol after double-bundle ACL reconstruction with hamstring grafts might have the potential risk of significant postoperative femoral bone tunnel enlargement of the posterolateral bundle. There was no significant difference in clinical outcomes by postoperative non-weight-bearing period. To reduce and prevent the femoral bone tunnel enlargement, the comprehensive management could be considered and required to establish the suitable early stage rehabilitation protocol after surgery. Trial registration: Trial registration number; UMIN000036212. Scientific title: Prospective comparisons of femoral tunnel enlargement with two different postoperative non weight bearing periods after double-bundle anterior cruciate ligament reconstruction with hamstring grafts. Registered date: 15 Mar 2019 (retrospectively registered).

DOI： 10.1186/s12891-019-2653-6

Effects of a valgus unloader brace in the medial meniscectomized knee joint: a biomechanical study Reviewed

サッカー日本女子代表（なでしこジャパン）のメディカルサポートを通して Invited Reviewed

山口奈美、田島卓也、長澤誠、森田雄大、帖佐悦男、園田典生

日本整形外科スポーツ医学会雑誌 39 ( 2 ) 10 - 14 2019.5

Language：Japanese Publishing type：Research paper (scientific journal)

全国レベルの高校空手道部の新入生メディカルチェック：3年間の結果より Reviewed

北堀貴史、森田雄大、長澤誠、黒木修司、山口奈美、田島卓也、石田康行、帖佐悦男

日本臨床スポーツ医学会誌 27 ( 2 ) 266 - 272 2019.4

Language：Japanese Publishing type：Research paper (scientific journal)

健康スポーツナース Reviewed

帖佐悦男

臨床整形外科 54 ( 4 ) 388 - 391 2019.4

Language：Japanese Publishing type：Research paper (scientific journal)

Identification of Key events in baseball hitting using inertial measurement units Reviewed

Journal of Biomechanics 87 ( 1 ) 157 - 160 2019.4

Language：English Publishing type：Research paper (scientific journal)

箸を用いた食事に必要な全身の関節角度と角度変化 Reviewed

中武潤, 鳥取部光司, 帖佐悦男

作業療法 38 ( 2 ) 163 - 170 2019.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人日本作業療法士協会

箸を用いた実際の食事に必要とされる正常な全身の関節角度と，その角度変化を検討することを目的に，三次元（3D）動作解析を行った．健常者45名の食事動作を，モーションキャプチャーシステムにて測定し，上下肢・頸部・体幹の関節角度を明らかにした．このうち，肘関節屈曲が最大約133°および最小約99°，手関節背屈が最大約30°および最小約10°であることを示した．また，関節角度の経時変化から，箸で食物を挟む時期に最も肩関節が内旋し，食物を口へ取り込む時期に最も肩関節が屈曲と外転し，頸部が伸展・右側屈・右回旋することがわかった．これらは，われわれが対象者の食事を評価し介入するための基礎知識になると考えられた．

DOI： 10.32178/jotr.38.2_163

姿勢重心計測機器を用いた健康づくり支援の検討 Reviewed

塩満智子,鶴田来美,帖佐悦男

日本整形外科スポーツ医学会雑誌 39 ( 1 ) 115 - 119 2019.3

Language：Japanese Publishing type：Research paper (scientific journal)

姿勢重心計測機器を用いた健康づくり支援の検討 Reviewed

塩満智子,鶴田来美,帖佐悦男

日本整形外科スポーツ医学会雑誌 39 ( 1 ) 115 - 119 2019.3

Language：Japanese Publishing type：Research paper (scientific journal)

ヘモグロビンは滑膜からADAMTS-5，-9の発現を亢進させる：関節血症の軟骨変性に及ぼす影響 Reviewed

田島卓也、谷口昇、山口奈美、帖佐悦男

日本関節鏡・膝・スポーツ整形外科学会雑誌 44 ( 1 ) 292 - 293 2019.3

Language：Japanese Publishing type：Research paper (scientific journal)

集中治療領域におけるリハビリテーションの役割:〜理学療法士の立場から考える〜 Invited Reviewed

小川灯子, 宮﨑茂明, 帖佐悦男, 鳥取部光司

循環制御 40 ( 1 ) 16 - 17 2019.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本循環制御医学会

DOI： 10.11312/ccm.40.16

実臨床における骨粗鬆症に対するイバンドロネート錠の短期臨床成績

小牧亘、深野木快士、福富雅子、上籠謙吏、大久保節子、前原孝政、帖佐悦男

宮崎整形外科研究会誌 ( 23 ) 8 - 11 2019.3

Language：Japanese Publishing type：Research paper (conference, symposium, etc.)

当院及び連携医療機関で投与した週1回テリパラチド製剤の治療成績

舩元太郎、帖佐悦男、川野啓一郎

宮崎整形外科研究会誌 ( 23 ) 44 - 45 2019.3

Language：Japanese Publishing type：Research paper (scientific journal)

組織学的所見を含めた非定型大腿骨骨折の骨癒合遷延に対する検討

小牧亘、深野木快士、曽根崎あけみ、福富雅子、舩元太郎、濱田浩朗、帖佐悦男、田中弘之、馬場貴

宮崎整形外科研究会誌 ( 23 ) 39 - 43 2019.3

Language：Japanese Publishing type：Research paper (conference, symposium, etc.)

Shriram D., Yamako G., Chosa E., Lee Y., Subburaj K.

Journal of orthopaedic surgery and research 14 ( 1 ) 44 2019.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of orthopaedic surgery and research

BACKGROUND: Patients undergoing total or partial arthroscopic meniscectomy for treating traumatic meniscal tears are at greater risk of developing knee osteoarthritis (OA) due to increased mechanical load. The purpose of this study was to evaluate the effects of a valgus unloader brace in the medial meniscectomized knee joint during the gait cycle. METHODS: A three-dimensional finite element model of the knee joint was developed using the substructures segmented from magnetic resonance images. Experimentally measured forces and moments for one complete gait cycle, without brace and with brace at three different alignment angles (0°, 4°, and 8°), were applied to the finite element model, and the changes in the tibiofemoral contact mechanics were estimated. RESULTS: The brace in 0°/4°/8° valgus alignment modes reduced the total contact force in the medial compartment by 16%/46%/82% at opposite toe off and 18%/17%/29% at opposite initial contact events, while it increased the total contact force in the lateral compartment by 31%/81%/110% at opposite toe off and 30%/38%/45% at opposite initial contact events, respectively, when compared to the unbraced meniscectomized knee. CONCLUSIONS: Increasing the valgus alignment from 0° to 4° and 8° resulted in a greater reduction of contact conditions (total contact force, total contact area, peak contact pressure) in the medial compartment and vice versa in the lateral compartment. This decrease in contact conditions in the medial compartment infers enhanced knee joint function due to a valgus unloader brace, which translates to increased knee-related confidence. Results suggest choosing a higher valgus alignment angle could potentially increase the risk for the onset of osteoarthritis in the lateral compartment, and this computational model could be used in validating the effectiveness of braces on joint health.

DOI： 10.1186/s13018-019-1085-1

Identification of key events in baseball hitting using inertial measurement units Reviewed

Punchihewa N., Yamako G., Fukao Y., Chosa E.

Journal of Biomechanics 87 157 - 160 2019.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Biomechanics

© 2019 Quantification of baseball hitting mechanics under game conditions help players to become successful batters and prevent injuries. Inertial measurement units (IMUs) can measure motion without any spatial restriction and are thus becoming a popular tool to investigate sports biomechanics. Biomechanical analysis of hitting requires the accurate detection of key events including “foot-off” while leaning back (F Off ), “foot-on” during forward swing (F On ), and ball impact. Ten male university baseball players hit a ball suspended on a T pole five times in kick-hitting and glide-hitting styles. Three IMUs were attached on mid-pelvis and on each hand to record acceleration and orientation data. The key events identified by the three IMUs were compared with those retrieved by an optical motion capture system with force platforms. The timings of the local peak acceleration of the pelvis in the direction of the pitcher that were recorded by the IMU closely matched those of F Off and F On events detected by the ground reaction force. Root mean square error (RMSE) between each measurement for the F Off and F On events were 0.024 and 0.031 s, respectively. The timing of the negative peak of acceleration in the proximal direction of the hands corresponded to the impact time determined by an optical motion capture system. RMSEs for the knob and barrel-side hand were 0.009 and 0.011 s, respectively. Our results demonstrate how IMUs can be useful for analyzing baseball hitting mechanics.

DOI： 10.1016/j.jbiomech.2019.02.001

Painful swelling of the arm due to a bizarre intramuscular vascular malformation Reviewed

Theodorou D., Theodorou S., Yano H., Chosa E., Marutsuka K., Kakitsubata Y.

Journal of Orthopaedic Science 27 ( 2 ) 504 - 507 2019

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

DOI： 10.1016/j.jos.2019.07.011

Analysis of Young's modulus gradation of femoral stem for reducing bone loss after total hip arthroplasty

NAKAI Ryosuke, OCHIAI Kiyohide, HANADA Shuji, CHOSA Etsuo, YAMAKO Go

The Proceedings of the JSME Conference on Frontiers in Bioengineering 2019 ( 0 ) 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers

DOI： 10.1299/jsmebiofro.2019.30.1B23

Measuring joint kinematics of baseball hitting using inertial measurement units

PUNCHIHEWA Niroshan G., GOTO Kazuki, CHOSA Etsuo, YAMAKO Go

The Proceedings of the JSME Conference on Frontiers in Bioengineering 2019 ( 0 ) 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers

DOI： 10.1299/jsmebiofro.2019.30.2C26

当科における頚椎ペディクルスクリュー法の術後成績と安全性の検討－O-arm、CTナビ、フリーハンドの刺入精度の比較検討－ Reviewed

濱中秀昭、黒木修司、比嘉聖、川野啓介、永井琢哉、李徳哲、帖佐悦男

Jouenal of Spine Research 9 ( 12 ) 1727 - 1730 2018.12

Language：Japanese Publishing type：Research paper (scientific journal)

ロコモティブシンドローム対策としてのPush-up法の意義 Reviewed

田島直也、野﨑正太郎、吉田暁生、大野源太、川門直記、島原千夏子、帖佐悦男

運動器リハビリテーション 29 ( 4 ) 435 - 439 2018.12

Language：Japanese Publishing type：Research paper (scientific journal)

Acetabular reinforcement ring with additional hook improves stability in three- dimensional finite element analyses of dysplastic hip arthroplasty Reviewed

Koji Totoribe, Etsuo Chosa, Go Yamako, Xin Zhao, Koki Ouchi, Hiroaki Hamada, Gang Deng

Journal of Orthopaedic Surgery and Research 13 ( 1 ) 313 2018.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Surgery and Research

© 2018 The Author(s). Background: The stability of acetabulum reconstructions using reinforcement rings and hooks is important for successful replacement surgery. The objective of this study was to biomechanically determine the effects of the hook on stress and the related micromotions of the acetabular reinforcement ring during the immediate postoperative period. Methods: Acetabular reinforcement ring models were developed using a nonlinear, three-dimensional, finite element method. Using a pre-prepared template, we constructed without-hook and bone graft models of varying volumes and material properties. Results: The stress on the inferior margin of the acetabulum was higher in the with-hook model than in the without-hook model, especially with increased bone graft volumes, and the stiffness of the bone graft material was decreased. Relative micromotions in the without-hook model were higher than in the with-hook models. The highest relative micromotion was observed in the model with increased bone graft volume and lower stiffness of bone graft material. Conclusions: In biomechanical analyses, the hook effectively dispersed stress and improved the initial fixation strength of the acetabular reinforcement ring.

DOI： 10.1186/s13018-018-1023-7

硬膜欠損を伴う脳表へモジデリン沈着症に対して硬膜閉鎖術を施行し、良好な経過をたどった1例 Reviewed

病理所見より検討した非定型大腿骨骨折の骨癒合遷延の要因 Reviewed

小牧亘、深野木快士、濱田浩朗、帖佐悦男、田中弘之、片岡寛章

骨折 41 ( 1 ) 267 - 272 2018.12

Language：Japanese Publishing type：Research paper (scientific journal)

当院における4例の非定型大腿骨骨折の組織学的所見の検討 Reviewed

小牧亘、深野木快士、舩元太郎、濱田浩朗、帖佐悦男、田中弘之、馬場貴

日本骨粗鬆症学会雑誌 4 ( 4 ) 485 - 495 2018.11

Language：Japanese Publishing type：Research paper (scientific journal)

成長期・育成世代のラグビー選手に対する外傷・脳振盪後の復帰プロトコル Reviewed

田島卓也，帖佐悦男

Monthly Book MEDICAL REHABILITATION 228 108 - 115 2018.10

Language：Japanese Publishing type：Research paper (scientific journal)

黒木智文、永井琢哉、北島潤弥、李徳哲、川野啓介、比嘉聖、黒木修司、関本朝久、濱中秀昭、帖佐悦男

整形外科と災害外科 67 ( 4 ) 819 - 822 2018.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

保存加療に抵抗性の硬膜欠損を伴う特発性脳表ヘモジデリン沈着症に対し，硬膜閉鎖術を施行し，良好な経過をたどった1例を経験した．症例は64歳，男性．1995年頃に騒音性難聴と診断されたが，日常生活に支障はなかった．2012年から歩行時のふらつき，2013年から右難聴，耳鳴が出現した．2014年に健康診断の頭部MRIにて，小脳萎縮と脳表へのヘモジデリン沈着を指摘された．2015年に止血剤投与，2016年にブラッドパッチ施行されるも，徐々に症状は増悪し，2017年当科紹介となった．入院時，両側感音難聴と体幹失調を認め，頚椎MRIのCISS法にてTh4/5レベルの硬膜腹側左傍正中部に6 mm×3 mm大の硬膜欠損，C6からTh7の脊柱管腹側硬膜外腔への液体貯留を認めた．後方進入による硬膜閉鎖術を施行し，歩行時のふらつきが改善した．硬膜欠損に伴う脳表ヘモジデリン沈着症に対しては，観血的な硬膜閉鎖術が有効であると考えられた．

DOI： 10.5035/nishiseisai.67.819

Double crushを呈していた橈尺骨骨幹部骨折後尺骨神経障害の1例 Reviewed

藤田貢司、石田康行、谷口昇、田島卓也、山口奈美、長澤誠、森田雄大、関本朝久、帖佐悦男

整形外科と災害外科 67 ( 4 ) 674 - 676 2018.9

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.5035/nishiseisai.67.674

高齢者の腱板断裂に伴う偽性麻痺肩に対する鏡視下手術の成績 Reviewed

石田康行, 長澤誠, 谷口昇, 帖佐悦男

肩関節 42 ( 2 ) 474 - 477 2018.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本肩関節学会

高齢者の腱板断裂に伴う偽性麻痺肩に対して，RSAを推奨する報告がある．今回70歳以上，自動挙上90度未満の腱板断裂例に対する鏡視下手術の成績を調査した．術後12ヶ月以上観察できた32肩を対象とした．年齢は平均73.9歳，観察期間は平均25.1ヶ月であった．手術法は一次修復術27肩，部分修復術3肩，パッチ法2肩であった．一次修復例の腱板修復状態を術後1年時MRIで調査し，菅谷分類別の術前後のJOAスコア，自動挙上角度（aAE）を調査した．部分修復術，パッチ法のJOAスコア，aAEも調査した．腱板修復状態はtype1，15肩，type3，1肩，type4，4肩，type5，7肩であった．JOAスコア，aAEは概ね改善していたがtype5とパッチ法が他より劣っていた．部分修復術は良好であった．RSAは最終手術である認識が必要である．低侵襲な鏡視下手術は有効で，今後さらに見直されるべきものと考える．

DOI： 10.11296/katakansetsu.42.474

野球検診で発見された上腕骨小頭離断性骨軟骨炎例の特徴 Reviewed

長澤誠, 石田康行, 谷口昇, 帖佐悦男

肩関節 42 ( 2 ) 552 - 554 2018.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本肩関節学会

近年，小頭離断性骨軟骨炎（以下OCD）の早期発見を目的とした野球検診が全国的に広がっている．我々も平成22年度より宮崎県少年野球検診を行っている． 　7年間で合計3051名が検診を受診し，OCDと診断されたのは84名（2.8%）であった．我々はOCDは投球機会の多い投手・捕手をしている体格のいいチームの中心選手に多い印象をもっている． 　それを検討するために体格（身長・体重）とポジション（投手・捕手をしているか），加えて投球時痛・小頭部圧痛・肘関節可動域制限の有無に関し，OCD群とコントロール群の2群間で検討したので報告する． 　結果は身長・体重に関しては有意差はなかった．投手・捕手の割合，投球時痛・小頭部圧痛・可動域制限がある割合はすべてOCD群で有意に高かった． 　OCDは投手捕手をしている選手に多く発生していた．ポジションや投球数を考慮した予防活動が必要である．

DOI： 10.11296/katakansetsu.42.552

Lumbar intervertebral disc degeneration in professional surfers Reviewed

Kojima T., Kubo S., Tajima N., Mitsuhashi R., Nozaki S., Chosa E.

Sports Orthopaedics and Traumatology 34 ( 3 ) 261 - 264 2018.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Sports Orthopaedics and Traumatology

© 2018 Elsevier GmbH Background: Surfing was added as an official event of the Tokyo Olympics in 2020. There are many surfers troubled by low back pain, but there is no scientific analysis until now. This time, we took MRI on the lumbar vertebrae in 20 official professional surfers and examined the relationship between the low back pain and the rate of the lumbar disc degeneration. Materials and methods: Subjects are 20 people (16 men, 4 women) of 17 Japan official professional surfers and 3 Japan official professionals bodydoaders in total, average age 29.8 years old (17–57 years), we investigated by use of the lumbar vertebrae T2-weighted magnetic resonance imaging. Results: 11 people (55%) had the low back pain, 10 people (50%)had the lumbar disc degeneration (more than Grade III of Pfirrmann classification), 2 people (10%) had the lumbar spondylolysis. There is no relationship between the low back pain and the rate of the disc degeneration. Conclusions: The prevalence rate of low back pain in the professional surfers was approximately equal to previous report. The prevalence rate of the lumbar disc degeneration was 50%, and it was not high rate particularly in comparison with baseball and the swimming. The surfing competition is easy to cause the low back pain, but is not easy to cause the disc degeneration.

DOI： 10.1016/j.orthtr.2018.06.006

Biomechanical analysis of supra-acetabular insufficiency fracture using finite element analysis Reviewed

Tanaka H., Yamako G., Kurishima H., Yamashita S., Mori Y., Chiba D., Chosa E., Itoi E.

Journal of orthopaedic science 23 ( 5 ) 825 - 833 2018.9

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jos.2018.04.005

遠隔医療システムを用いたラグビー新サポートシステムの可能性～ITシステムが新たな安全対策のソリューションになり得るか～ Reviewed

中村嘉宏、帖佐悦男、田島卓也、吉川大輔、黒木修司、比嘉聖

日本整形外科スポーツ医学会雑誌 38 ( 3 ) 44 - 50 2018.7

Language：Japanese Publishing type：Research paper (scientific journal)

サッカー日本女子代表：メディカルサポートの実際と課題 Invited Reviewed

山口奈美、石田康行、田島卓也、森田雄大、帖佐悦男、園田典生

日本整形外科スポーツ医学会雑誌 38 ( 3 ) 5 - 9 2018.7

Language：Japanese Publishing type：Research paper (scientific journal)

VISSLA ISA World Junior Surfing Championship 2017 in Hyugaのメディカルサポート報告 Reviewed

小島岳史，三股奈津子，三橋龍馬，田島直也，岩田昌，大野源太，郷之原愛，尾崎勝博，市井竜弥，出口綾乃，河原勝博，石田翔太郎，永井琢哉，帖佐悦男，中野有貴，今村秋雄，落合優

九州・山口スポーツ医・科学研究会誌 30 21 - 25 2018.7

Language：Japanese Publishing type：Research paper (scientific journal)

School scoliosis screening by Moiré topography – Overview for 33 years in Miyazaki Japan Reviewed

Hiroshi Kuroki、Takuya Nagai、Etsuo Chosa、Naoya Tajima

Journal of Orthopaedic Science 23 ( 4 ) 609 - 613 2018.7

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jos.2018.03.005

橈骨茎状突起部骨折に大菱形骨骨折を伴うCM関節脱臼骨折を合併した1例 Reviewed

小牧亘、深野木快士、濱田浩朗、帖佐悦男

骨折 40 ( 3 ) 627 - 630 2018.6

Language：Japanese Publishing type：Research paper (scientific journal)

HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles Reviewed

Lee D, Taniguchi N, Sato K, Choijookhuu N, Hishikawa Y, Kataoka H, Morinaga H, Lotz M, Chosa E

Scientific Reports 8 ( 1 ) 9601 - 9613 2018.6

Language：English Publishing type：Research paper (scientific journal)

Finite element analysis of the tibial bone graft in cementless total knee arthroplasty Reviewed

Koji Totoribe, Etsuo Chosa, Go Yamako, Hiroaki Hamada, Koki Ouchi, Shutaro Yamashita and Gang Deng

Journal of Orthopaedic Surgery and Research 13 ( 1 ) 113 - 120 2018.5

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s13018-018-0830-1

A new scale measuring translation of the humeral head as a prognostic factor for the treatment of large and massive rotator cuff tears Reviewed

麻酔下ストレステスト（evaluation under anesthesia;EUA)が有用であった寛骨臼後壁骨折の2症例 Reviewed

日吉優，川野啓介，中村嘉宏，池尻洋史，帖佐悦男

骨折 40 ( 2 ) 400 - 401 2018.4

Language：Japanese Publishing type：Research paper (scientific journal)

Laeson変法を用いた膝後外側支持機構再建術 Reviewed

山口奈美,田島卓也,石田康行,谷口昇,大田智美,長澤誠,帖佐悦男

日本関節鏡・膝・スポーツ整形外科學會雑誌 43 ( 2 ) 506 - 507 2018.4

Language：Japanese Publishing type：Research paper (scientific journal)

宮崎県少年野球検診−検診結果と可動域の関係− Reviewed

長澤誠、石田康行、谷口昇、田島卓也、山口奈美、三橋龍馬、川野啓介、帖佐悦男

日本関節鏡・膝・スポーツ整形外科學會雑誌 43 ( 2 ) 562 - 563 2018.4

Language：Japanese Publishing type：Research paper (scientific journal)

ロボットスーツＨＡＬの使用で歩行能力の改善を認めた不全頚髄損傷患者の1例 Reviewed

鳥取部光司, 帖佐悦男, 濱田浩朗, 李徳哲, 深尾悠, 山口洋一朗

宮崎県医師会医学会誌 42 ( 1 ) 78 - 81 2018.3

Language：Japanese Publishing type：Research paper (scientific journal)

Quantitative assessment of locomotive syndrome in Japanese office workers Reviewed

Tsuruta Kurumi, Yoshinaga Saori, Shiomitsu Tomoko, Tamura Hiroki, Fujii Yoshinori, Chosa Etsuo

The Journal of Physical Fitness and Sports Medicine 7 ( 2 ) 143 - 149 2018.3

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.7600/jpfsm.7.143

膝関節内側半月後角損傷に対し一期的に半月縫合とＨＴＯを施行した1例 Reviewed

小島岳史，齊藤由紀子，三橋龍馬，帖佐悦男

日本関節鏡・膝・スポーツ整形外科學會雑誌 43 ( 1 ) 230 - 231 2018.3

Language：Japanese Publishing type：Research paper (scientific journal)

脛骨付着部を温存した自家半健様筋健グラフトによるＭＣＬ再建術の術後短期成績 Reviewed

田島卓也、山口奈美、谷口昇、石田康行、大田智美、長澤誠、帖佐悦男

日本関節鏡・膝・スポーツ整形外科學會雑誌 43 ( 1 ) 180 - 181 2018.3

Language：Japanese Publishing type：Research paper (scientific journal)

前十字靭帯後外側線維束脛骨付着部裂離骨折に対しULTRABRAIDを用いたsuture fixationにて手術を施行した1症例 Reviewed

三橋龍馬，小島岳史，齊藤由紀子，帖佐悦男

日本関節鏡・膝・スポーツ整形外科學會雑誌 43 ( 1 ) 176 - 177 2018.3

Language：Japanese Publishing type：Research paper (scientific journal)

外側広範型上腕骨小頭離断性骨軟骨炎の手術成績を左右する因子 Reviewed

石田康行、長澤誠、谷口昇、田島卓也、山口奈美、大田智美、帖佐悦男

日本関節鏡・膝・スポーツ整形外科學會雑誌 43 ( 1 ) 16 - 17 2018.3

Language：Japanese Publishing type：Research paper (scientific journal)

Quantitative assessment of locomotive syndrome in Japanese office workers Reviewed

Kurumi Tsuruta、Saori Yoshinaga、Tomoko Shiomitsu、Hiroki Tamura、Yoshinori Fujii、Etsuo Chosa

The Journal of Physical Fitness and Sports Medicine 7 ( 2 ) 143 - 149 2018.3

Language：English Publishing type：Research paper (scientific journal)

当院における高齢者大腿骨頚部骨折に対するカラードステム人工骨頭置換術の治療成績 Reviewed

戸田雅,森治樹,河野勇泰喜,山口洋一朗,関本朝久,帖佐悦男

整形外科と災害外科 67 ( 2 ) 322 - 324 2018.3

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.5035/nishiseisai.67.322

ＩＰ関節の色素沈着を伴い発症した関節リウマチ症例

濱田浩朗、古結英樹、関本朝久、田島卓也、天野正宏、帖佐悦男

宮崎県医師会医学会誌 42 ( 1 ) 97 - 104 2018.3

Language：Japanese Publishing type：Research paper (bulletin of university, research institution)

Taniguchi N, D'Lima DD, Suenaga N, Chosa E

Journal of Shoulder and Elbow Surgery 27 ( 2 ) 196 - 203 2018.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Shoulder and Elbow Surgery

© 2017 Journal of Shoulder and Elbow Surgery Board of Trustees Background Failure rates after rotator cuff repair remain high in patients with massive tears. Although superior translation of the humeral head has been used to assess the severity of rotator cuff tears, the relevance of anterior migration of the humeral head to clinical outcomes has not been established. The purpose of this study was to investigate the potential role of the T-scale, a measure of the anterolateral translation of the humeral head, as a prognostic factor for rotator cuff repair. Methods One hundred twenty consecutive patients with full-thickness rotator cuff tears underwent primary rotator cuff repair. The T-scale and acromiohumeral interval (AHI) were measured preoperatively on axial computed tomography scans and radiographs, respectively. The correlations of the T-scale and AHI with previously published scores and active forward elevation (FE) were investigated. The outcome of rotator cuff repairs was compared between patients with positive and patients with negative preoperative T-scale values. Results The preoperative T-scale but not AHI correlated significantly with postoperative FE and clinical scores in patients with large to massive tears but not in those with small to medium tears. Postoperative FE and clinical scores were significantly higher in patients with positive T-scale values than in those with negative T-scale values. The relative risk of retear was 2.0 to 7.9 times greater in patients with negative T-scale values. Conclusion Patie nts with large to massive tears and negative T-scale values had poorer clinical outcomes and higher retear rates. A negative T-scale value represents a useful prognostic factor for considering reverse shoulder arthroplasty in patients at greater risk of retear after rotator cuff repair.

DOI： 10.1016/j.jse.2017.08.026

Translation of the humeral head scale is associated with success of rotator cuff repair for large-massive tears. Reviewed

原発性骨粗鬆症に対するイバンドロネート錠の短期臨床成績の検討 Reviewed

小牧亘,深野木快士,福富雅子,上籠謙吏,大久保節子,前原孝政,帖佐悦男

新薬と臨床 67 ( 1 ) 3 - 11 2018.1

Language：Japanese Publishing type：Research paper (scientific journal)

ロコモティブシンドロームの現状と対策

帖佐　悦男

体力科学 67 ( 1 ) 18 - 18 2018

Language：Japanese Publishing type：Research paper (scientific journal)

放射線照射後に生じた股関節障害に対し寛骨臼再建を併用して人工股関節置換術を施行した1例 Reviewed

吉留綾, 川野啓介, 藤田貢司, 帖佐悦男, 坂本武郎, 関本朝久, 濱田浩朗, 池尻洋史, 中村嘉宏, 舩元太郎, 日吉優

整形外科と災害外科 67 ( 2 ) 315 - 317 2018

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.5035/nishiseisai.67.315

Taniguchi N, D'Lima DD, Suenaga N, Ishida Y, Lee D, Goya I, Chosa E

BMC Musculoskeletal Disorders 18 ( 1 ) 511 - 519 2017.12

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Musculoskeletal Disorders

© 2017 The Author(s). Background: Although a loss of rotator cuff integrity leads to the superior migration of the humeral head, the parameters that characterize the anterolateral migration of the humeral head have not been established. The purpose of this study was to investigate the correlation between the translation of the humeral head scale (T-scale) and clinical outcomes of rotator cuff repair, as well as the correlation between the T-scale and radiologic parameters. Methods: One hundred thirty-five consecutive patients with full-Thickness rotator cuff tears underwent primary rotator cuff repair. The T-scale, which indicates the distance from the center of the humeral head to the lateral coracoacromial arch, was measured on axial computed tomography scans, and the acromiohumeral interval (AHI) was measured radiographically. The correlation of the two parameters with the clinical scores of the Japanese Orthopaedic Association and University of California-Los Angeles scores and active forward elevation (FE) were evaluated at the preoperative and postoperative stages, respectively. Results: The postoperative T-scale and AHI correlated well with the postoperative FE and clinical scores in the patients with large-massive tears but not in those patients with small-medium tears and preoperative large-massive tears. A significant correlation was observed between the postoperative T-scale and AHI. The T-scale was subject to cuff repair integrity. Conclusions: We demonstrated that the postoperative T-scale was well correlated with the clinical results and postoperative AHI after rotator cuff repair for large-massive tears, indicating that poor outcomes are associated with combined superior and anterolateral migration of the humeral head following retears.

DOI： 10.1186/s12891-017-1874-9

Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells; a possible cause of articular cartilage damage after intra-articular hemorrhage Reviewed

宮崎県における側弯症学校検診の過去15年間の変遷 Reviewed

黒木浩史,永井琢哉,帖佐悦男,田島直也

Journal of spine research 8 ( 11 ) 1712 - 1715 2017.11

Language：Japanese Publishing type：Research paper (scientific journal)

Tajima T., Sekimoto T., Yamaguchi N., Taniguchi N., Kurogi S., Maruyama M., Chosa E.

BMC Musculoskeletal Disorders 18 ( 1 ) 449 - 457 2017.11

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Musculoskeletal Disorders

© 2017 The Author(s). Background: ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stage osteoarthritis. To determine the effect of hemoglobin (Hb) on the ability of synovial tissues to produce ADAMTS family members, we examined the influence of Hb by synovial cells in an in vitro experimental system. Methods: Synovial tissues were obtained from five young patients with meniscal injury under arthroscopic surgery. Primary cultures of human knee synovial cells were treated with different doses of human Hb (0, 25, 50, 100 μg/ml). The culture media were collected 24 h after Hb-treatment. In the time-course studies, cells were treated with and without 100 μg/ml Hb, and culture media were taken at 6, 12, and 24 h. To identify the proteins responsible for aggrecanase activity, Western blot analysis using antibodies against human ADAMTS-5, -8, -9, and -10; enzyme-linked immunosorbent assay (ELISA); and gene ex pression for ADAMTS-5 and -9 were examined. Statistical comparisons between each group were performed using paired t-tests. Results: Western blot analysis revealed that Hb-treatment resulted in the expression of ADAMTS-5 and -9. Neither control group nor Hb-treated medium showed immunoreactivity against ADAMTS-8 or -10. In a dose-dependency study, the Hb-treated group showed significantly higher levels of ADAMTS-5 and -9 compared with the control (p < 0.05). There was no significant difference between 25, 50, and 100 μg/ml Hb-treated groups. In a time-course study, the ADAMTS-5 and -9 levels in the conditioned medium had significantly increased expression at 6, 12, and 24 h in the Hb-treated group (p < 0.05). Hb evoked significant expression of ADAMTS-9 mRNA at 12 and 24 h (p < 0.05). Conclusions: These findings indicate that Hb induces the expression of ADAMTS-5 and -9 by synovial cells at low doses, even at an acute phase, and suggests a possible role for Hb in cartilage damage after intra-articular hemorrhage. The results also suggest a new potential therapeutic target by inhibiting the activities of ADAMTS-5 and -9 to prevent cartilage damage after intra-articular hemorrhage.

DOI： 10.1186/s12891-017-1815-7

Ultrasonographic evaluation of changes in the muscle architecture of the gastrocnemius with botulinum toxin treatment for lower extremity spasticity in children with cerebral palsy. Reviewed

Kawano A, Yanagizono T, Kadouchi I, Umezaki T, Chosa E

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 23 ( 2 ) 389 - 393 2017.11

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jos.2017.10.012

Quantification of the sit-to-stand movement for monitoring age-related motor deterioration using the Nintendo Wii Balance Board Reviewed

Yamako G., Chosa E., Totoribe K., Fukao Y., Deng G.

PLoS ONE 12 ( 11 ) e0188165 2017.11

Language：English Publishing type：Research paper (scientific journal) Publisher：PLoS ONE

© 2017 Yamako et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Simple methods for quantitative evaluations of individual motor performance are crucial for the early detection of motor deterioration. Sit-to-stand movement from a chair is a mechanically demanding component of activities of daily living. Here, we developed a novel method using the ground reaction force and center of pressure measured from the Nintendo Wii Balance Board to quantify sit-to-stand movement (sit-to-stand score) and investigated the age-related change in the sit-to-stand score as a method to evaluate reduction in motor performance. The study enrolled 503 participants (mean age ± standard deviation, 51.0 ± 19.7 years; range, 20–88 years; male/female ratio, 226/277) without any known musculoskeletal conditions that limit sit-to-stand movement, which were divided into seven 10-year age groups. The participants were instructed to stand up as quickly as possible, and the sit-to-stand score was calculated as the combination of the speed and balance indices, which have a tradeoff relationship. We also performed the timed up and go test, a well-known clinical test used to evaluate an individual’s mobility. There were significant differences in the sit-to-stand score and timed up and go time among age groups. The mean sit-to-stand score for 60s, 70s, and 80s were 77%, 68%, and 53% of that for the 20s, respectively. The timed up and go test confirmed the age-related decrease in mobility of the participants. In addition, the sit-to-stand score measured using the Wii Balance Board was compared with that from a laboratory-graded force plate using the Bland–Altman plot (bias = −3.1 [ms] -1 , 95% limit of agreement: −11.0 to 3.9 [ms] -1 ). The sit-to-stand score has good inter-device reliability (intraclass correlation coefficient = 0.87). Furthermore, the test–retest reliability is substantial (intraclass correlation coefficient = 0.64). Thus, the proposed STS score will be useful to detect the early deterioration of motor performance.

DOI： 10.1371/journal.pone.0188165

Improving stress shielding following total hip arthroplasty by using a femoral stem made of β type Ti-33.6Nb-4Sn with a Young's modulus gradation Reviewed

ロコモ予防としての子どもの運動器検診―なぜ子どものころからロコモ予防が必要か―

帖佐悦男

THE BONE 31 ( 3 ) 83 - 88 2017.10

Language：Japanese Publishing type：Research paper (scientific journal)

Yamako G., Janssen D., Hanada S., Anijs T., Ochiai K., Totoribe K., Chosa E., Verdonschot N.

Journal of Biomechanics 63 135 - 143 2017.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Biomechanics

© 2017 Elsevier Ltd Stress shielding-related bone loss occurs after total hip arthroplasty because the stiffness of metallic implants differs from that of the host femur. Although reducing stem stiffness can ameliorate the bone resorption, it increases stress at the bone–implant interface and can inhibit fixation. To overcome this complication, a novel cementless stem with a gradient in Young's modulus was developed using Ti-33.6Nb-4Sn (TNS) alloy. Local heat treatment applied at the neck region for increasing its strength resulted in a gradual decrease in Young's modulus from the proximal to the distal end, from 82.1 to 51.0 GPa as calculated by a heat transfer simulation. The Young's modulus gradient did not induce the excessive interface stress which may cause the surface debonding. The main purpose of this study was to evaluate bone remodeling with the TNS stem using a strain-adaptive bone remodeling simulation based on finite element analysis. Our predictions showed that, for the TNS stem, bone reduction in the calcar region (Gruen zone 7) would be 13.6% at 2 years, 29.0% at 5 years, and 45.8% at 10 years postoperatively. At 10 years, the bone mineral density for the TNS stem would be 42.6% higher than that for the similar Ti-6Al-4V alloy stem. The stress–strength ratio would be lower for the TNS stem than for the Ti-6Al-4V stem. These results suggest that although proximal bone loss cannot be eliminated completely, the TNS stem with a Young's modulus gradient may have bone-preserving effects and sufficient stem strength, without the excessive interface stress.

DOI： 10.1016/j.jbiomech.2017.08.017

アテトーゼ型脳性麻痺患者の肩痛に対して鏡視下バンカート修復術が有効であった1例 Reviewed

関節リウマチの薬物療法 Reviewed

濱田浩朗, 帖佐悦男

関節外科 34 ( 10月増刊号 ) 52 - 56 2017.10

Language：Japanese Publishing type：Research paper (scientific journal)

胸椎硬膜外に発生した血管脂肪腫の1例 Reviewed

川越秀一、濱中秀昭、黒木修司、比嘉聖、川野啓介、永井琢哉、李徳哲、関本朝久、帖佐悦男

整形外科と災害外科 66 ( 4 ) 715 - 717 2017.9

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.5035/nishiseisai.66.761

石田康行, 長澤誠, 谷口昇, 大田智美, 中村志保子, 帖佐悦男

肩関節 41 ( 2 ) 613 - 615 2017.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本肩関節学会

　アテトーゼ型脳性麻痺の32歳女性で単回の右肩亜脱臼後に肩痛が持続した．運動療法で改善しなかったため，鏡視下デブリードマンを行った．術後4か月で右肩痛が再発した．不随意運動のため，肩関節不安定性が運動療法で制御できないものと考え，鏡視下バンカート修復術を行った．術後右肩痛は改善した．不随意運動を伴う肩痛は，微小な肩関節不安定性が原因である可能性があることを念頭に置く必要がある．

DOI： 10.11296/katakansetsu.41.613

超音波検査による小児股関節炎の検討

小島岳史、柏木輝行、花堂祥治、矢野良英、帖佐悦男

宮崎県医師会医学会誌 41 ( 2 ) 82 - 84 2017.9

Language：Japanese Publishing type：Research paper (conference, symposium, etc.)

Summary of Medical Support Reporting - 3 Season to the Professional Team Spring Training Camp in Miyazaki Prefecture(2014-2016)- Reviewed

37 ( 3 ) 57 - 62 2017.7

Language：Japanese Publishing type：Research paper (scientific journal)

Copy number loss in the region of the ASPN gene in patients with acetabular Dysplasia Reviewed

Sekimoto T., Ishii M., Emi M., Kurogi S., Funamoto T., Yonezawa Y., Tajima T., Sakamoto T., Hamada H., Chosa E.

Bone and Joint Research 6 ( 7 ) 439 - 445 2017.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Bone and Joint Research

© 2017 Cao et al. Objectives: We have previously investigated an association between the genome copy number variation (CNV) and acetabular dysplasia (AD). Hip osteoarthritis is associated with a genetic polymorphism in the aspartic acid repeat in the N-terminal region of the asporin (ASPN) gene; therefore, the present study aimed to investigate whether the CNV of ASPN is involved in the pathogenesis of AD. Methods: Acetabular coverage of all subjects was evaluated using radiological findings (Sharp angle, centre-edge (CE) angle, acetabular roof obliquity (ARO) angle, and minimum joint space width). Genomic DNA was extracted from peripheral blood leukocytes. Agilent's regiontargeted high-density oligonucleotide tiling microarray was used to analyse 64 female AD patients and 32 female control subjects. All statistical analyses were performed using EZR software (Fisher's exact probability test, Pearson's correlation test, and Student's t-test). Results: CNV analysis of the ASPN gene revealed a copy number loss in significantly more AD patients (9/64) than control subjects (0/32; p = 0.0212). This loss occurred within a 60 kb region on 9q22.31, which harbours the gene for ASPN. The mean radiological parameters of these AD patients were significantly worse than those of the other subjects (Sharp angle, p = 0.0056; CE angle, p = 0.0076; ARO angle, p = 0.0065), and all nine patients required operative therapy such as total hip arthroplasty or pelvic osteotomy. Moreover, six of these nine patients had a history of operative or conservative therapy for developmental dysplasia of the hip. Conclusions: Copy number loss within the region harbouring the ASPN gene on 9q22.31 is associated with severe AD. A copy number loss in the ASPN gene region may play a role in the aetiology of severe AD.

DOI： 10.1302/2046-3758.67.BJR-2016-0094.R1

アマチュアサーファーの腰痛に関するアンケート調査 Reviewed

石田翔太郎、帖佐悦男、小島岳史

九州・山口スポーツ医・科学研究会誌 29 28 - 31 2017.7

Language：Japanese Publishing type：Research paper (scientific journal)

サッカー選手の鎖骨骨幹部骨折―骨接合術で早期復帰は可能か？― Reviewed

小島岳史、久保紳一郎、齊藤由希子、三橋龍馬、野崎正太郎、田島直也、帖佐悦男

九州・山口スポーツ医・科学研究会誌 29 75 - 80 2017.7

Language：Japanese Publishing type：Research paper (scientific journal)

下腿長を考慮した立ち上がり能力測定およびその測定結果と年齢との相関 Reviewed

鄧鋼, 帖佐悦男, 鳥取部光司, 山子剛

運動器リハビリテーション = The journal of musculoskeletal medicine : 日本運動器科学会誌 28 ( 1 ) 68 - 75 2017.5

Language：Japanese Publishing type：Research paper (scientific journal)

Shoulder and elbow pain in elementary school baseball players: The_results from a nation-wide survey in Japan. Reviewed

Takagishi K, Matsuura T, Masatomi T, Chosa E, Tajika T, Watanabe M, Iwama T, Otani T, Inagaki K, Ikegami H, Aoki M, Kato K, Okuwaki T, Sairyo K, Kameyama Y, Maeda A, Beppu M

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 22 ( 4 ) 682 - 686 2017.5

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jos.2017.03.016

Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models Reviewed

開放性膝関節脱臼後に前十字、後十字、内側側副靭帯　および　後外側支持機構を同時再建した１例 Reviewed

田島卓也、山口奈美、谷口昇、石田康行、大田智美、長澤誠、帖佐悦男

Journal of Japanese Orthopaedic Society of Knee, Arthoroscopy and Sports Medicine JOSKAS 42 ( 2 ) 372 - 373 2017.4

Language：Japanese Publishing type：Research paper (scientific journal)

当院における Fibrin Clot を用いた関節鏡視下半月縫合術の治療経験（共著） Reviewed

戸田雅, 田島卓也, 山口奈美, 帖佐悦男

整形外科と災害外科 66 ( 2 ) 254 - 257 2017.3

Language：Japanese Publishing type：Research paper (scientific journal)

仙骨骨巨細胞腫の2例（共著） Reviewed

濱中秀昭, 黒木修司, 比嘉聖, 永井琢哉, 川野啓介, 李徳哲, 戸田雅, 川越秀一, 帖佐悦男

整形外科と災害外科 66 ( 1 ) 165 - 169 2017.3

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.5035/nishiseisai.66.165

スポーツ活動者の外傷性肩関節前方不安定症に対する鏡視下バンカート修復術の成績（共著） Reviewed

横江琢示, 石田康行, 田島卓也, 帖佐悦男

日本整形外科スポーツ医学会雑誌 37 ( 1 ) 59 - 63 2017.3

Language：Japanese Publishing type：Research paper (scientific journal)

ラグビーワールドカップ2019におけるメディカルネットワーク構築（共著） Reviewed

田島卓也, 中村明彦, 帖佐悦男

臨床スポーツ医学 34 ( 2 ) 106 - 110 2017.2

Language：Japanese Publishing type：Research paper (scientific journal)

Kurogi S., Sekimoto T., Funamoto T., Ota T., Nakamura S., Nagai T., Nakahara M., Yoshinobu K., Araki K., Araki M., Chosa E.

Scientific Reports 7 40692 2017.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports

© The Author(s) 2017.Despite numerous genetic studies on bone metabolism, understanding of the specific mechanisms is lacking. We developed an efficient screening system to identify novel genes involved in bone metabolism using mutant mouse strains registered with the Exchangeable Gene Trap Clones (EGTC) database. From 1278 trap clones in the EGTC database, 52 candidate lines were selected in the first screening, determined based on "EST profile", "X-gal", "Related article", and "Novel gene". For the second screening, bone morphometric analysis, biomechanical strength analysis, bone X-gal staining, etc. were performed on candidate lines. Forty-two male trap lines (80.8%) showed abnormalities with either bone morphometric analysis or biomechanical strength analysis. In the screening process, X-gal staining was significantly efficient (P = 0.0057). As examples, Lbr and Nedd4 trap lines selected using the screening system showed significant bone decrease and fragility, suggesting a relationship with osteoblast differentiation. This screening system using EGTC mouse lines is extremely efficient for identifying novel genes involved in bone metabolism. The gene trap lines identified as abnormal using this screening approach are highly likely to trap important genes for bone metabolism. These selected trap mice will be valuable for use as novel bio-resources in bone research.

DOI： 10.1038/srep40692

多発性に肺結節を伴いゾレドロネート併用化学療法を施行した骨肉腫 Reviewed

子どもには運動（外遊び）が必要 -なぜ子どもの頃からロコモ予防が必要か-（平成28年度からの学童期運動器検診の開始を受けて） Reviewed

帖佐悦男

臨床スポーツ医学 34 ( 1 ) 82 - 84 2017.1

Language：Japanese Publishing type：Research paper (scientific journal)

運動ロコモティブシンドローム予防・改善のために必要な健康スポーツ・運動 Invited Reviewed

帖佐悦男

臨床スポーツ医学 34 ( 1 ) 2017.1

Language：Japanese Publishing type：Research paper (scientific journal)

陳旧性小指PIP関節橈側側副靱帯損傷に対する治療経験 Reviewed

大田智美, 中村志保子, 帖佐悦男, 矢野浩明

日本手外科学会雑誌 33 ( 4 ) 510 - 513 2017.1

Language：Japanese Publishing type：Research paper (scientific journal)

黒木純, 盛武浩, 山田愛, 木下真理子, 澤大介, 上村幸代, 中村嘉宏, 帖佐悦男, 中田博, 盛口淸香, 浅田祐士郎, 布井博幸

日本小児血液・がん学会雑誌 54 ( 1 ) 54 - 57 2017

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本小児血液・がん学会

骨肉腫は小児骨悪性腫瘍で最も多い疾患である．限局例の治療成績は向上したが，転移例に確立された治療法はなく極めて予後不良である．近年，海外においてビスフォスフォネート製剤併用の臨床研究が行われ注目されている．我々は診断時多発性肺結節を認めゾレドロネート併用化学療法を施行した症例を経験した．症例は左大腿骨原発骨肉腫の14歳男児．切断患肢の病理で腫瘍細胞は完全壊死を示し術前化学療法への感受性は極めて良好であった．全治療終了時，肺結節は多くは変化なく残存したが一部消失した．血液毒性以外の重篤な副作用は認めなかった．多発性肺結節が肺内リンパ節であった可能性が高く有効性評価は困難であるが，骨肉腫に対するビスフォスフォネート製剤併用化学療法の安全性は確認できた．今後，本邦での症例蓄積により安全性や有効性の確認が望まれる．

DOI： 10.11412/jspho.54.54

Influence of Gender Differences on Range of Motion and Joint Angles During Eating in Young, Healthy Japanese Adults Reviewed

Nakatake Jun, Totoribe Koji, Chosa Etsuo, Yamako Go, Miyazaki Shigeaki

Progress in Rehabilitation Medicine 2 ( 0 ) 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：公益社団法人日本リハビリテーション医学会

Objective: Eating is important in rehabilitation and is evaluated using joint angles that serve as kinematic information. Joint angles of the upper extremities during eating have been reported for men and for women; however, no study has investigated these joint angles in terms of gender differences. At present, no information is available on gender differences as individual factors of upper extremity joint angles during eating. Therefore, the present study investigated gender differences in upper limb joint angles during eating tasks involving a spoon or chopsticks. Methods: We examined eating motions in 12 healthy Japanese men and 13 healthy Japanese women (aged 20–39 years) and compared the two groups. Motions were assessed using inertial sensors and three-dimensional motion analysis. Results: We established, separately for men and women, the maximum angle and the range of motion (RoM) for each upper limb joint. Women generally had greater RoMs for all upper limb joints than men did. When subjects used a spoon, statistically significant differences and large effect sizes were observed for the maximum elbow joint flexion angle and the RoMs of the shoulder joint in abduction, flexion, and internal rotation. When subjects used chopsticks, statistically significant differences and large effect sizes were observed for maximum angles of shoulder joint internal rotation, elbow joint flexion, and wrist joint radial flexion and for the RoM of shoulder joint abduction. Conclusions: We concluded that there are significant gender differences in upper limb joint angles during eating, and that these differences are influenced by numerous factors.

DOI： 10.2490/prm.20170011

変形性関節症のリハビリテーション（共著） Reviewed

鳥取部光司, 帖佐悦男, 宮﨑茂明

The　Japanese　Journal　of　Rehabilitation Medicine 53 ( 12 ) 922 - 927 2016.12

Language：Japanese Publishing type：Research paper (scientific journal)

地域における運動の啓発活動　-ロコモザワールド宮崎 Reviewed

帖佐悦男

日本医師会雑誌 145 ( 9 ) 1865 - 1868 2016.12

Language：Japanese Publishing type：Research paper (scientific journal)

宮崎県における側彎症専門外来の診療状況とその変遷（共著） Reviewed

黒木浩史, 猪俣尚規, 永井琢哉, 帖佐悦男, 田島直也

Journal of Spine Research 7 ( 11 ) 1605 - 1608 2016.11

Language：Japanese Publishing type：Research paper (scientific journal)

大腿骨転子部骨折術後に巨大血腫を併発し骨溶解した１例

小牧亘, 深野木快士, 濱田浩朗, 帖佐悦男

宮崎整形外科懇話会論文集 21 9 - 12 2016.11

Language：Japanese Publishing type：Research paper (conference, symposium, etc.)

液体窒素処理骨を用いて再建を行った骨軟部組織腫瘍の治療成績

中村嘉宏、帖佐悦男、坂本武郎、池尻洋史、舩元太郎、日吉　優、川野啓介

宮崎整形外科懇話会論文集 21 67 - 70 2016.11

Language：Japanese Publishing type：Research paper (conference, symposium, etc.)

大腿骨近位部病的骨折に対して腫瘍用人工骨頭を用いた治療成績

日吉　優、帖佐悦男、坂本武郎、濱田浩朗、池尻洋史、中村嘉宏、舩元太郎、川野啓介、三股奈津子、北島潤弥

宮崎整形外科懇話会論文集 21 59 - 61 2016.11

Language：Japanese Publishing type：Research paper (conference, symposium, etc.)

宮崎大学整形外科関連病院における学会活動と論文執筆活動−でキャリアアップは可能なのか’外病院‘いわゆる−

小島岳史、久保紳一郎、田島直也、野﨑正太郎、三橋龍馬、帖佐悦男

宮崎整形外科懇話会論文集 21 55 - 57 2016.11

Language：Japanese Publishing type：Research paper (conference, symposium, etc.)

骨粗鬆症に対する本院の地域における取り組み

小牧　亘、深野木快士、大久保節子、山内三和、前原孝政、福富雅子、吉村美樹、井料田光浩、濱田浩朗、帖佐悦男　　

宮崎整形外科懇話会論文集 21 35 - 39 2016.11

Language：Japanese Publishing type：Research paper (conference, symposium, etc.)

疲労骨折の画像診断 Reviewed

帖佐悦男

整形・災害外科 59 ( 11 ) 1411 - 1418 2016.10

Language：Japanese Publishing type：Research paper (scientific journal)

ロコモティブシンドロームの国民的認知度向上とエビデンス構築に向けた活動-地域におけるロコモ認知度向上と前向き介入研究 Reviewed

帖佐悦男

日本整形外科學曾雑誌 90 ( 10 ) 813 - 820 2016.10

Language：Japanese Publishing type：Research paper (scientific journal)

Duechenne跛行が股関節接触位置と臼蓋部応力状態に及ぼす影響の評価に関する検討（共著） Reviewed

大内宏輝, 鄧鋼, 鳥取部光司, 帖佐悦男, 山子剛

臨床バイオメカニクス 37 69 - 76 2016.10

Language：Japanese Publishing type：Research paper (scientific journal)

リアルタイムMEPモニタリング下に腸腰筋に浸潤した後腹膜腫瘍を摘出した1例（共著） Reviewed

平川雄介, 帖佐悦男, 濱中秀昭, 猪俣尚規, 黒木修司, 比嘉聖, 永井琢哉, 李徳哲, 横江琢示

整形外科と災害外科 65 ( 3 ) 561 - 564 2016.9

Language：Japanese Publishing type：Research paper (scientific journal)

骨巨細胞腫2例に対するDenosumabを用いた治療経験（共著） Reviewed

戸田雅, 帖佐悦男, 坂本武郎, 関本朝久, 渡邊信二, 濱田浩朗, 池尻洋史, 中村嘉宏, 舩元太朗, 日吉優, 川野啓介, 齊藤由希子

整形外科と災害外科 65 ( 4 ) 655 - 657 2016.9

Language：Japanese Publishing type：Research paper (scientific journal)

肩鎖関節脱臼に対する新しい手術デバイス”Zip TightⓇ”の使用経験（共著） Reviewed

小島岳史, 久保紳一郎, 田島直也, 野崎正太郎, 三橋龍馬, 帖佐悦男

整形外科と災害外科 65 ( 4 ) 756 - 760 2016.9

Language：Japanese Publishing type：Research paper (scientific journal)

寛骨臼球骨切り（SAO）後の関節症進行に対する治療戦略～骨切り術から人工関節に至るまでの治療の軌跡～（共著） Reviewed

中村嘉宏, 帖佐悦男, 坂本武郎, 渡邊信二, 関本朝久, 池尻洋史, 舩元太郎, 日吉優, 川野啓介

整形外科と災害外科 65 ( 3 ) 396 - 399 2016.9

Language：Japanese Publishing type：Research paper (scientific journal)

Surgical Treatment for Hemodialysis Associated Cervical Spondyloarthropahy（共著） Reviewed

H.Kuroki,H Hamanaka,N Inomata,T Nagai,E Chosa

Clinics in Surgery 1 1 - 5 2016.9

Language：English Publishing type：Research paper (scientific journal)

Screening for musculoskeletal problems in Japanese schoolchildren: a cross-sectional study nested in a cohort（共著） Reviewed

N.Yamaguchi，E.Chosa，K.Yamamoto，K.Kawahara，H.Hamada，N.Taniguchi，T.Tajima，T.Funamoto，S.Kurogi，T.Ota，S.Nakamura

Public Health 139 189 - 197 2016.8

Language：English Publishing type：Research paper (scientific journal)

A novel protocol to test age-related decreases in sit-to-stand movement abilities in healthy subjects

Yamako G., Deng G., Totoribe K., Chosa E.

Journal of Orthopaedic Science 21 ( 4 ) 517 - 523 2016.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

© 2016 The Japanese Orthopaedic AssociationBackground The development of simple approaches to quantitatively estimate functional motor performance in a wide range of ages is crucial for early detection of locomotive syndrome (LS). Sit-to-stand (STS) movements from a chair are important in activities of daily living (ADL), although such tasks are the most mechanically demanding among all ADL. Here, we propose a novel test to score STS abilities to estimate individual functional motor status and investigated age-related changes in STS scores as a method to evaluate reduction in performance. Methods A total of 606 healthy subjects (average age, 48.4 years; age range, 20–87 years) without neuromusculoskeletal disorders participated in the study. We designed a test to score STS abilities, based on STS determinant variables, including seat height, foot positioning, and both-leg- or one-leg-standing tasks. STS scores ranged from 0 to 14 points, depending on the difficulty or mechanical demands of the STS task. We evaluated the STS score of the subjects divided into seven 10-year age groups. Results A significant and negative correlation was observed between STS scores and subject age (men: r = −0.65, P < 0.001; women: r = −0.62, P < 0.001). The proportion of subjects able to stand on one leg from a chair seat height of 100% of knee height decreased with age from 100% for both men and women aged 20–29 years to 0.0% and 7.1% for men and women aged 80–87 years, respectively. A large variation in STS scores was observed for subjects aged >60 years. There was a negative linear correlation between mean STS score per age group and mean age (men: R2 = 0.93, slope = −0.10, intercept = 16.63 points; women: R2 = 0.92, slope = −0.08, intercept = 14.76 points). Conclusions The ability to perform STS was negatively correlated with age among healthy subjects aged 20–87 years. For subjects aged >60 years, STS abilities decreased, but within-group variability increased. This test was useful to identify the deterioration of functional motor performance and prevent early LS.

DOI： 10.1016/j.jos.2016.04.006

宮崎大学医学部整形外科のスポーツイベントへの帯同状況

膝関節外側滑膜ヒダ障害による弾発膝を来した1例 Reviewed

三股奈津子, 石田康行, 谷口昇, 田島卓也, 山口奈美, 大田智美, 帖佐悦男

九州・山口スポーツ医・科学研究会誌 28 78 - 80 2016.7

Language：Japanese Publishing type：Research paper (scientific journal)

MRIによるプロサーファーの椎間板変性の検討～第1報～ Reviewed

小島岳史, 久保紳一郎, 三橋龍馬, 野崎正太郎, 田島直也, 原田昭彦, 尾崎勝博, 落合錠, 横田薫, 帖佐悦男

九州・山口スポーツ医・科学研究会誌 28 56 - 60 2016.7

Language：Japanese Publishing type：Research paper (scientific journal)

非定型大腿骨骨折の検討 Reviewed

小牧亘, 深野木快士, 濱田浩朗, 帖佐悦男

骨折 38 ( 3 ) 704 - 708 2016.6

Language：Japanese Publishing type：Research paper (scientific journal)

障害者スポーツの病態解析と機器の開発の研究-バイオメカニクス研究を中心に-（共著） Reviewed

帖佐悦男, 鳥取部光司, 田村宏樹, 黒木洋美, 山子剛

デサントスポーツ 37 35 2016.6

Language：Japanese Publishing type：Research paper (scientific journal)

Remnant-preserving, selective single-bundle augmentation of the anterior cruciate ligament using a bone-patellar tendon-bone autograft: A technical note. Reviewed

Tajima T, Chosa E, Yamaguchi N, Taniguchi N, Ishida Y.

The Knee 23 ( 3 ) 554 - 558 2016.6

Language：English Publishing type：Research paper (scientific journal)

当科における仙骨脊索腫の手術成績 Reviewed

濱中秀昭, 猪俣尚規, 黒木修司, 比嘉聖, 永井琢哉, 李徳哲, 平川雄介, 横江琢示, 帖佐悦男

Journal of Spine Research 7 ( 5 ) 955 - 959 2016.5

Language：Japanese Publishing type：Research paper (scientific journal)

骨頭骨折を合併した寛骨臼後壁骨折に対する治療戦略　Surgical dislocationの有用性 Reviewed

中村嘉宏, 帖佐悦男, 池尻洋史, 日吉優, 川野啓介

骨折 38 ( 2 ) 341 - 345 2016.4

Language：Japanese Publishing type：Research paper (scientific journal)

BTBと薄筋腱を併用した2重束ACL再建術の臨床成績と画像評価 Reviewed

田島卓也、石田康行、谷口昇、山口奈美、帖佐悦男

JOSKAS 41 ( 1 ) 116 - 117 2016.3

Language：Japanese Publishing type：Research paper (scientific journal)

Angiotensin II Stimulation of Cardiac Hypertrophy and Functional Decompensation in Osteoprotegerin-Deficient Mice. Reviewed

Toshihiro Tsuruda, Yoko Sekita-Hatakeyama, Yilin Hao, Sumiharu Sakamoto, Syuji Kurogi, Midori Nakamura, Nobuyuki Udagawa, Taro Funamoto, Tomohisa Sekimoto, Kinta Hatakeyama, Etsuo Chosa, Johji Kato, Yujiro Asada, Kazuo Kitamura

Hypertension 2016.3

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1161/HYPERTENSIONAHA.115.06689

Clinical result of terrible triad of the shoulder without operation Reviewed

The Shoulder Joint 39 ( 3 ) 783 - 786 2016.3

Language：Japanese Publishing type：Research paper (scientific journal)

Empty can test

石田康行、帖佐悦男

関節外科 35 ( 3 ) 324 - 325 2016.2

Language：Japanese Publishing type：Research paper (scientific journal)

Remnant-preservint, selective single-bundle augmentation of the anterior cruciate ligament using a bone-patellar tendon-bone autograft: a technical note(共著) Reviewed

Takuya Tajima, Etsuo Chosa, Nami Yamaguchi, Noboru Taniguchi, Yasuyuki Ishida

The Knee 2016.2

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.knee.2015.11.024

Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene Reviewed

Yilin Hao, Toshihiro Tsuruda, Yoko Sekita-Hatakeyama, Syuji Kurogi, Keishi Kubo, Sumiharu Sakamoto, Midori Nakamura, Nobuyuki Udagawa, Tomohisa Sekimoto, Kinta Hatakeyama, Etsuo Chosa, Yujiro Asada, Kazuo Kitamura

Cardiovascular Research 2016.1

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/cvr/cvw025

豆状骨脱臼を合併した橈骨遠位端骨折の1例 Reviewed

小牧亘、濱田浩朗、永井琢哉、帖佐悦男

骨折 38 ( 1 ) 36 - 41 2016.1

Language：Japanese Publishing type：Research paper (scientific journal)

横江琢示, 田島卓也, 中村嘉宏, 山口奈美, 黒木修司, 帖佐悦男

整形外科と災害外科 65 ( 1 ) 54 - 57 2016

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

宮崎大学医学部整形外科は宮崎県と連携し，積極的にスポーツイベントへのメディカルサポートを行なっている．平成25年度に当科が行ったメディカルサポート状況につき調査した．宮崎大学医学部整形外科所属の医師が出務した宮崎県外・海外へのチーム帯同や医事運営は10件でその期間は3日間から32日間であった．内訳としては，U-17女子サッカー日本代表帯同が3件，国民体育大会（国体）宮崎県選手団帯同が3件，国体サッカー少年の部帯同が3件，全国高校ラグビー大会帯同が1件であった．宮崎県内で開催されたスポーツイベントのマッチドクター，医事運営への出務は46競技会62日間であった．内訳としては，ラグビー32日，サッカー11日，柔道8日，マラソン2日でその他競技が9日であった．出務医師総数は15人で8人はスポーツドクター資格保持者であった．当科でのスポーツイベントへの医師派遣の現状および課題について報告する．

DOI： 10.5035/nishiseisai.65.54

当科における外傷性肩関節前方不安定症に対する 鏡視下バンカート修復術の成績

石田康行, 長澤誠, 谷口昇, 大田智美, 中村志保子, 帖佐悦男

肩関節 40 ( 3 ) 843 - 847 2016

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本肩関節学会

　外傷性肩関節前方脱臼に対する鏡視下バンカート修復術（ABR）の術後成績を調査し，その問題点を検討した．2005年から2014年までにABRを行い，術後12ヶ月以上観察できた74肩を対象とした．年齢は平均27.6歳．経過観察期間は平均20.6ヶ月，追加手術は腱板疎部縫縮術，SLAP修復術，関節包断裂修復術であった．臨床成績を術前術後のJSS-SIS，Rowe scoreで評価し，術後関節可動域を自動前方挙上，他動下垂位外旋（ER1），90°外転位外旋（ER2），結帯（ADD）で評価した．再脱臼の有無を調査した．JSS-SIS，Rowe scoreは術前と比べ術後に有意に改善した．術後日常生活に支障をきたす可動域制限はなかった．術後健側と比較して患側のER1，ER2，ADDが低下していた．追加手術の有無で可動域に差はなかった．再脱臼は4肩に認め，全例ラグビーでの再受傷であった．コリジョンアスリート例では再受傷の危険性があり，鏡視下手術を行う際にはABRに加え，Remplissage等のより強固な補強術が必要と思われた．

DOI： 10.11296/katakansetsu.40.843

寛骨臼球状骨切り（SAO）後の関節症進行に対する治療戦略　～骨切り術から人工関節に至るまでの治療の軌跡～

中村嘉宏, 帖佐悦男, 坂本武郎, 渡邊信二, 関本朝久, 池尻洋史, 舩元太郎, 日吉優, 川野啓介

整形外科と災害外科 65 ( 3 ) 396 - 399 2016

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会

寛骨臼球状骨切り後に股関節症の進行を来した症例への人工関節置換術に関し報告する．

DOI： 10.5035/nishiseisai.65.396

Surgical Outcomes for Osteochondritis Dissecans of the Humeral Capitellum in Adolescent Baseball Players

Ishida Yasuyuki, Chosa Etsuo, Nagasawa Makoto, Taniguchi Noboru, Yamaguchi Nami, Oota Tomomi, Nakamura Shihoko

Journal of Japan Elbow Society 23 ( 2 ) 366 - 370 2016

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Elbow Society

DOI： 10.24810/jelbow.23.2_366

Intracalvarial Penetration of a Halo Pin During Treatment of an Odentoid Fracture in an Elderly Patient: A Cace Report(共著) Reviewed

Hiroshi Kuroki, Takuya Hagai, Hideaki Hamanaka, Naoki Inomata, Kiyoshi Higa, Etsuo Chosa, Shinji Yamashita, Hideo Takeshima.

MEDICAL SCIENCE CASE REPORTS 2 58 - 63 2015.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.12659/MSCR.896183

人工股関節の緩みに対する臼蓋再建の治療戦略

戸田雅, 帖佐悦男, 坂本武郎, 渡邊信二, 関本朝久, 濱田浩朗, 池尻洋史, 中村嘉宏, 舩元太郎, 日吉優, 川野啓介, 斎藤由希子

宮崎整形外科懇話会論文集 ( 20 ) 65 - 66 2015.12

Language：Japanese Publishing type：Research paper (scientific journal)

非定型大腿骨骨折の検討

小牧亘, 深野木快士, 濱田浩朗, 帖佐悦男

宮崎整形外科懇話会論文集 ( 20 ) 39 - 42 2015.12

Language：Japanese Publishing type：Research paper (scientific journal)

肩鎖関節脱臼に対する新しい手術デバイス+B42“Zip Tight”の使用経験

小島岳史, 岡村龍, 松岡篤, 黒田宏, 帖佐悦男

宮崎整形外科懇話会論文集 ( 20 ) 5 - 6 2015.12

Language：Japanese Publishing type：Research paper (scientific journal)

Clinical Results of Subacute and Chronic Atlantoaxial Rotatory Fixation Reviewed

Takuya Nagai, Hideaki Hamanaka, Naoki Inomata, Kiyoshi Higa, Lee Deok Cheol, Hiroyuki Imazato, Etsuo Chosa

6 ( 12 ) 1758 - 1760 2015.12

Language：Japanese Publishing type：Research paper (scientific journal)

J0230401 Optimal clearance on sliding surface of metal-on-metal hip prostheses processed by EL1D grinding system

OTSUKA Yuki, YAMAKO Go, DENG Gang, TOTORIBE Kouzi, CHOSA Etsuo, ISHIZAKA Naoto, WASA Motoki, FUJITA Masahiro

Mechanical Engineering Congress, Japan 2015 "J0230401 - 1"-"J0230401-3" 2015.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers

In total hip arthroplasty, the use of metal-on-metal bearings (MOM) had been increasing with expansion of demand for higher physical activities in young patients before clinical studies reported that metal ion release caused by wear leads to metal allergy and pseudotumour. Using ELID grinding system we have developed low friction and wear MOM to reduce these adverse reactions. The ELID system produces thick oxide layer on bearing surface that can inhibit metal ion release. The lubrication performance on friction and wear depends on geometric design and surface feature. Therefore, this study demonstrated the optimal clearance of the newly developed MOM for reducing metal ion release. We evaluated the influence of diametrical clearance on friction using a hip friction simulator. The nine φ36 mm femoral heads and 9 liners were prepared with 13 nm in roughness (Ra), and 2 μm in sphericity and were divided into three bearing groups based on the diametrical clearance (C_d = 20, 50, 70 μm). The frictional moment generated in each bearing under walking was measured and the frictional coefficient was calculated. The frictional coefficient decreased with reducing in the clearance but, maximum value was observed in C_d = 20 μm. In the clearance group of 20 μm, we expected the hydrodynamic lubrication because the Λ value defined as the ratio between lubricant thickness and average roughness is almost 3.0. Too small clearance induced the severe contact. Thus, our results suggest that the optimal clearance of new MOM is 50 μm to enhance lubrication performance.

Influence of leg-length discrepancy on anterior acetabular coverage using false profile image(共著) Reviewed

Masaki Kudo, Tomohisa Sekimoto, Takero Sakamoto, Etsuo Chosa.

Journal of Orthopaedic Science 20 ( 5 ) 861 - 867 2015.9

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00776-015-0738-0

Trade-off between stress shielding and initial stability on an anatomical cementless stem shortening: In-vitro biomechanical study

Yamako G., Chosa E., Totoribe K., Watanabe S., Sakamoto T.

Medical Engineering and Physics 37 ( 8 ) 820 - 825 2015.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Medical Engineering and Physics

© 2015 IPEM.Shortened cementless femoral stems have become popular with the advent of minimally invasive total hip arthroplasty (THA). Successful THA requires initial stem stability and prevention of stress shielding-mediated bone loss, although the effect of stem shortening is controversial. Here we experimentally examined whether stem shortening affects stress shielding and initial stability. Anatomical stems (length, 120mm) were cut to an 80mm or 50mm length. Ten tri-axial strain gauges measured the cortical strain on each stem-implanted femur to evaluate stress shielding. Two transducers measured axial relative displacement and rotation under single-leg stance loading. The 50mm stem increased the equivalent strains with respect to the original stem in the proximal calcar region (31.0% relative to intact strain), proximal medial region (63.1%), and proximal lateral region (53.9%). In contrast, axial displacement and rotation increased with a decreasing stem length. However, the axial displacement of the 50mm stem was below a critical value of 150μm for bone ingrowth. Our findings indicate that, with regard to a reduction in stem length, there is a tradeoff between stress shielding and initial stability. Shortening the stem up to 50mm can promote proximal load transfer, but bone loss would be inevitable, even with sufficient initial stability for long-term fixation.

DOI： 10.1016/j.medengphy.2015.05.017

jointly worked Reviewed

37 ( 8 ) 820 - 825 2015.8

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.medengphy.2015.05.017.

宮崎県における2014春季キャンプに対するメディカルサポート報告－キャンプの地の総合的メディカルサポート体制の構築にむけて－(共著)

小島岳史, 田島卓也, 帖佐悦男, 石田康行, 河原勝博, 山口奈美, 日吉優, 永井琢哉, 園田典生, 松岡知己, 井上篤, 田島直也, 山本惠太郎, 樋口潤一

九州・山口スポーツ医・科学研究会志 ( 27 ) 4 - 7 2015.7

Language：Japanese Publishing type：Research paper (scientific journal)

Morphologic changes of anchor holes by using full-thread anchors after the suture bridge technique"jointly worked" Reviewed

Journal of Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine 40 ( 3 ) 587 - 590 2015.6

Language：Japanese Publishing type：Research paper (scientific journal)

Two siblings with neuropathic scoliosis caused by Chiari malformation type I with syringomyelia(共著) Reviewed

Hiroshi Kuroki, Naoki Inomata, Hideaki Hamanaka, Kiyoshi Higa, Etsuo Chosa, Naoya Tajima.

Journal of Orthopaedic Science 20 ( 3 ) 579 - 583 2015.5

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00776-013-0520-0

Clinical Courses of Osteochondritis Dissecans of the Humeral Capitellum Found by Medical Checkup for Child and Adolescent Baseball Players Reviewed

Japanese Journal of ORTHOPAEDIC SPORTS MEDICINE 35 ( 2 ) 139 - 143 2015.5

Language：Japanese Publishing type：Research paper (scientific journal)

Pseudoaneurysm as a complication of shoulder arthroscopy Reviewed

Yasuyuki Ishida, Ethuo Chosa, Noboru Taniguchi

Knee Surgery, Sports Traumatology, Arthroscopy 23 ( 5 ) 1549 - 1551 2015.5

Language：English Publishing type：Research paper (scientific journal)

Pseudoaneurysm as a complication of shoulder arthroscopy.

Ishida Y, Chosa E, Taniguchi N

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 23 ( 5 ) 1549 - 51 2015.5

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00167-014-2956-y

Possible association of single nucleotide polymorphisms in the 3' untranslated region of HOXB9 with acetabular overcoverage

Treatment Strategy for Cervical Myelopathy in Patients with Athetoid Cerebral Palsy(共著) Reviewed

Hiroshi Kuroki, Shinichiro Kubo, Hideaki Hamanaka, Naoki Inomata, Kiyoshi Higa, Etsuo Chosa.

International Journal of Orthopaedics 2 ( 2 ) 243 - 249 2015.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.6051/j.issn.2311-5106.2015.02.60

Efficacy of the Osaka Medical College(OMC) brace in the treatment of adolescent idiopathic scoliosis following Scoliosis Research Society brace studies criteria(共著) Reviewed

Hiroshi Kuroki, Naoki Inomata, Hideaki Hamanaka, Kiyoshi Higa, Etsuo Chosa, Naoya Tajima.

Scoliosis 10 ( 12 ) 2015.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s13013-015-0036-9

Predictive factors of Osaka Medical College(OMC) brace treatment in patients with adolescent idiopathic scoliosis(共著) Reviewed

Hiroshi Kuroki, Naoki Inomata, Hideaki Hamanaka, Kiyoshi Higa, Etsuo Chosa, Naoya Tajima.

Scoliosis 10 ( 11 ) 2015.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s13013-015-0038-7

Surgical treatment of femoral trochanteric fractures using the 120°nail -About poor result cases-"jointly worked" Reviewed

Journal of Japanese Society for Fracture Repair 37 ( 3 ) 720 - 724 2015.4

Language：Japanese Publishing type：Research paper (scientific journal)

Prospective Comparisons of Femoral Tunnel Enlargement With 3 Different Postoperative Immobilization Periods After Double-Bundle Anterior Cruciate Ligament Reconstruction With Hamstring Grafts(共著) Reviewed

Takuya Tajima, Etsuo Chosa, Katsuhiro Kawahara, Nami Yamaguchi.

Arthroscopy 31 ( 4 ) 651 - 658 2015.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.arthro.2014.10.015

Possible association of single nucleotide polymorphisms in the 3' untranslated region of HOXB9 with acetabular overcoverage(共著) Reviewed

T Sekimoto, S Kurogi, T Funamoto, T Ota, S Watanabe, T Sakamoto, H Hamada, E Chosa.

Bone & Joint Research 4 ( 4 ) 50 - 55 2015.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1302/2046-3758.44.2000349

Sekimoto T., Kurogi S., Funamoto T., Ota T., Watanabe S., Sakamoto T., Hamada H., Chosa E.

Bone and Joint Research 4 ( 4 ) 50 - 55 2015.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Bone and Joint Research

© 2015 The British Editorial Society of Bone and Joint Surgery.Objectives: Excessive acetabular coverage is the most common cause of pincer-type femoroacetabular impingement. To date, an association between acetabular over-coverage and genetic variations has not been studied. In this study we investigated the association between single nucleotide polymorphisms (SNPs) of paralogous Homeobox (HOX)9 genes and acetabular coverage in Japanese individuals to identify a possible genetic variation associated with acetabular overcoverage. Methods: We investigated 19 total SNPs in the four HOX9 paralogs, then focused in detail on seven of those located in the 3' untranslated region of HOXB9 (rs8844, rs3826541, rs3826540, rs7405887, rs2303485, rs2303486, rs79931349) using a case-control association study. The seven HOXB9 SNPs were genotyped in 316 subjects who had all undergone radiological examination. The association study was performed by both single-locus and haplotypebased analyses. Results: The genotype and allele frequencies of the five HOXB9 SNPs showed significant association with acetabular over-coverage compared with controls (rs7405887 OR = 3.16, p = 5.29E-6, 95% CI 1.91 to 5.25). A significant difference was also detected when haplotypes were evaluated (OR = 2.59, p = 2.61E-5, 95% CI 1.65 to 4.08). The two HOXB9 SNPs (rs2303485, rs2303486) were associated with decreased acetabular coverage (rs2303485 OR = 0.524, p = 0.0091, 95% CI 0.322 to 0.855; rs2303486 OR = 0.519, p = 0.011, 95% CI 0.312 to 0.865). Conclusions: The five HOXB9 SNPs (rs8844, rs3826541, rs3826540, rs7405887, rs79931349) were associated with acetabular over-coverage. On the other hand, the two SNPs (rs2303485 and rs2303486) were associated with the lower acetabular coverage. The association of rs2303486 would be consistent with the previous study. Therefore, the HOXB9 SNPs might be involved in the morphogenesis of acetabular coverage, and could be an independent risk factor for developing pincer-type femoroacetabular impingement.

DOI： 10.1302/2046-3758.44

1A32 Biomechanical evaluation of Ganz ring in total hip arthroplasty

多発性硬化症（MS）を合併した頚髄症に手術療法を施行した1例 Reviewed

濱中秀昭, 猪俣尚規, 比嘉聖, 永井琢哉, 山口洋一朗, 今里浩之, 帖佐悦男

整形外科と災害外科 64 ( 1 ) 25 - 28 2015.3

Language：Japanese Publishing type：Research paper (scientific journal)

自家ハムストリング腱を用いたbi-socket法によるPCL再建術の術後短期成績 Reviewed

田島卓也, 河原勝博, 山口奈美, 石田康行, 谷口昇, 帖佐悦男

日本関節鏡・膝・スポーツ整形外科学会雑誌（JOSKAS） 40 ( 1 ) 176 - 177 2015.3

Language：Japanese Publishing type：Research paper (scientific journal)

NAKAMURA Kosuke, YAMAKO Go, DENG Gang, OTSUKA Hiroki, TOTORIBE Koji, SAKAMOTO Takero, CHOSA Etsuo

2015 ( 27 ) 29 - 30 2015.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers

2F23 Characteristics of hip joint contact for different gait patterns

OUCHI Koki, DENG Gang, YAMAKO Go, CHOSA Etsuo, TOTORIBE Koji

2015 ( 27 ) 523 - 524 2015.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers

Bosworth型足関節脱臼骨折の2例:―術後長期経過例―

小島岳史, 黒田宏, 岡村龍, 松岡篤, 帖佐悦男

整形外科と災害外科 64 ( 4 ) 837 - 841 2015

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

腓骨遠位部骨折に伴う整復困難な足関節脱臼骨折であるBosworth骨折を2例経験し術後長期経過したので報告する．【症例1】18歳男性．交通外傷後近医に搬送．徒手整復できず直達牽引施行されたが整復不能．受傷5日目に当院紹介入院．同日腰麻下にORIF施行．術後4週で全荷重歩行開始し，術後10ヶ月で疼痛，可動域制限なく骨癒合得られ抜釘術を行った．術後9年でJSSF scale 100点であった．【症例2】53歳男性．2 mの高さより転落し受傷．同日腰麻下に，観血的整復術施行．受傷後10日目にORIF施行．術後6週で全荷重歩行とし，術後10ヶ月で疼痛，可動域制限なく骨癒合得られ抜釘術を行った．術後3年で軽度の不安定性を認めJSSF scale 92点であった．【考察】本症例は1947年にBosworthが報告した腓骨遠位部骨折を伴った足関節の脱臼骨折で，腓骨近位骨片が脛骨後方に転位し固定され整復が障害されるものである．Lauge-HansenのSupination-External rotation損傷（以下SER損傷）と診断してしまうと，初期治療を誤る可能性があり注意が必要である．

DOI： 10.5035/nishiseisai.64.837

手術を行わなかった腋窩神経麻痺を伴った腱板広範囲断裂の経過

石田康行, 帖佐悦男, 矢野浩明, 谷口昇, 大田智美, 中村志保子

肩関節 39 ( 3 ) 783 - 786 2015

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Shoulder Society

　腱板断裂に伴った腋窩神経麻痺の多くが自然回復することから，早期の腱板修復術を推奨する報告がある．しかし，一次修復不能な断裂では治療方針に苦慮する．手術を行わなかった腋窩神経麻痺を伴った腱板広範囲断裂の経過を調査した．症例は5肩．年齢は69～79歳，経過観察期間12～44ヵ月であった．全例肩関節前方脱臼に伴った腱板広範囲断裂と腋窩神経麻痺であった．麻痺回復徴候を認めた時期，受傷前の自動挙上角度に回復した時期と，初診時と最終観察時のJOA scoreの疼痛，機能，可動域で調査した．全例，受傷前の挙上角度に回復し，麻痺回復徴候を認めた時期は2～6ヵ月，受傷前の挙上に回復した時期は5～12ヵ月であった．JOA scoreは初診時平均32.5点が最終観察時平均60.5点へ有意に改善していた．腋窩神経麻痺を伴った腱板断裂に対する手術は絶対適応ではなく，断裂腱板の状態で検討すべきと考える．

DOI： 10.11296/katakansetsu.39.783

Temporal trends in characteristics of newly diagnosed nontraumatic osteonecrosis of the femoral head from 1997 to 2011: A hospital-based sentinel monitoring system in Japan

Takahashi S., Fukushima W., Yamamoto T., Iwamoto Y., Kubo T., Sugano N., Hirota Y., Matsuno T., Ito H., Kishida S., Nakamura J., Nakamura Y., Kishiya M., Yasunaga Y., Yamasaki T., Takahashi D., Asano T., Majima T., Komiya S., Ishidou Y., Arishima Y., Kabata T., Matsumoto T., Kaneuji A., Ohzono K., Itoman M., Nishiyama T., Fujishiro T., Higuchi F., Okawa T., Fujioka M., Ueshima K., Motomura G., Sudo A., Chosa E., Osaki M., Hasegawa Y., Endo N., Tokunaga K., Kaku N., Nishii T., Sakai T., Takao M., Takaoka K., Nakamura H., Iwaki H., Miki H., Hotokebuchi T., Mawatari M., Ninomiya S., Taneda H., Nagoya S., Kodaira H., Atsumi T., Kobayashi S., Tanaka S., Ito H., Yamamoto K., Jinno T., Koga D., Takagi M., Sasaki K., Inaba Y., Kobayashi N.

Journal of Epidemiology 25 ( 6 ) 437 - 444 2015

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Epidemiology

© 2015 Shinji Takahashi et al. Background: Nontraumatic osteonecrosis of the femoral head (ONFH) is a rare disorder caused by ischemic necrosis of unknown etiology. A few studies have demonstrated trends in the number of patients with ONFH. However, there are no data on temporal trends in characteristics such as age, gender, and causative factors. To investigate this, we examined data from a multicenter hospital-based sentinel monitoring system in Japan. Methods: A total of 3041 newly-diagnosed ONFH patients from 34 participating hospitals who were reported to the system from 1997-2011 were analyzed. We examined age at diagnosis, potential causative factors, and underlying diseases for which patients received systemic steroid administration. Their temporal trends were assessed according to date of diagnosis in 5-year intervals (1997-2001, 2002-2006, and 2007-2011). Results: The gender ratio and distribution of potential causative factors did not change. Regarding underlying diseases requiring steroid administration, the proportion of patients with systemic lupus erythematosus decreased in males (10% to 6.4%) and in females (37% to 29%). Proportion of patients with renal transplantation fell consistently across the study period in both males (3.8% to 1.2%) and females (3.2% to 0.8%). In contrast, the proportion of patients receiving steroids for pulmonary disease (except asthma) significantly increased in both males (0.5% to 5.5%) and females (0.5% to 3.6%). Conclusions: This large descriptive study is the first to investigate temporal trends in the characteristics of ONFH, which provide useful information for future studies.

DOI： 10.2188/jea.JE20140162

当科におけるsuture bridge法による鏡視下腱板修復術 －suture bridgeの縫合法の違いによる比較－

Tajima T, Chosa E, Kawahara K, Yamaguchi N.

Arthroscopy 864 - 870 2014.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.arthro.2014.10.014.

Bone marow stimulation at the footprint of arthroscopic surface-holding repair advances cuff repair integrity.(共著) Reviewed

Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Yamaguchi H, Inoue K, Chosa E.

Journal of Shoulder and Elbow Surgery 24 ( 6 ) 860 - 866 2014.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jse.2014.09.031

検診で発見された上腕骨小頭離断性骨軟骨炎の特徴 Reviewed

石田康行, 帖佐悦男, 矢野浩明, 山口奈美, 大田智美, 中村志保子

日本肘関節学会雑誌 21 ( 2 ) 177 - 180 2014.12

Language：Japanese Publishing type：Research paper (scientific journal)

In-vitro biomechanical evaluation of stress shielding and initial stability of a low-modulus hip stem made of β type Ti-33.6Nb-4Sn alloy. Reviewed

Yamako G, Chosa E, Totoribe K, Hanada S, Masahashi N, Yamada N, Itoi E.

Medical Engineering & Physics 1665 - 1671 2014.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.medengphy.2014.09.002.

Comprehensive Safety Manegement and Assessment at Rugby Football Competitions. Invited Reviewed

Tajima T, Chosa E, Kawahara K, Nakamura Y, Yoshikawa D, Yamaguchi N, Kashiwagi T.

International Journal of sports medicine 35 1012 - 1016 2014.12

Language：English Publishing type：Research paper (scientific journal)

Treatment of osteochondritis dissecans of humeral capitellum Invited Reviewed

Journal of Joint Surgery 33 ( 11 ) 39 - 43 2014.11

Language：Japanese Publishing type：Research paper (scientific journal)

Medical check up for youth baseball players in Miyazaki. Reconsideration and improvement. Invited Reviewed

Journal of Joint Surgery 33 ( 11 ) 86 - 91 2014.11

Language：Japanese Publishing type：Research paper (scientific journal)

腰痛・膝痛のリハビリテーション Invited Reviewed

.帖佐悦男

臨床と研究 91 ( 11 ) 1460 - 1464 2014.11

Language：Japanese Publishing type：Research paper (scientific journal)

肩関節 Invited Reviewed

石田康行, 宮﨑茂明, 帖佐悦男

Monthy Book Medical Rehabilitation 176 87 - 95 2014.11

Language：Japanese Publishing type：Research paper (scientific journal)

Chronic sports injuries of the pelvis,hip and thigh Invited Reviewed

4 ( 4 ) 633 - 640 2014.10

Language：Japanese Publishing type：Research paper (scientific journal)

在宅ロコモ対策支援（ロコモコール）の意義と効果 Invited Reviewed

帖佐悦男, 中村耕三, 藤野圭司, 安村誠司, 高岸憲二, 石田健司, 遠藤直人, 石橋英明, 千田益生, 島田洋一, 阿久根徹

整形・災害外科 57 ( 11 ) 1433 - 1439 2014.10

Language：Japanese Publishing type：Research paper (scientific journal)

地域密着の介護予防支援活動の戦略　－ロコモコール（厚労省班研究）を中心に－ Reviewed

帖佐悦男, 中村耕三, 藤野圭司, 安村誠司, 高岸憲二, 遠藤直人, 石田健司, 石橋英明, 千田益生, 島田洋一, 阿久根徹

日本整形外科学会雑誌 88 ( 10 ) 743 - 749 2014.10

Language：Japanese Publishing type：Research paper (scientific journal)

Bone marrow stimulation at the footprint of arthroscopic surface-holding repair advances cuff repair integrity. Reviewed

Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Yamaguchi H, Inoue K, Chosa E.

Journal of Shoulder and Elbow Surgery 530 - 538 2014.9

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jse.2014.09.031.

Motor function diagnosis using a motion analysis system Invited Reviewed

Journal of Joint Surgery 33 ( 10 ) 14 - 19 2014.9

Language：Japanese Publishing type：Research paper (scientific journal)

ランニング障害とその対策：股関節 Invited Reviewed

田島卓也, 帖佐悦男

臨床スポーツ医学 31 ( 9 ) 884 - 889 2014.9

Language：Japanese Publishing type：Research paper (scientific journal)

Pelvic motion analysis while paddling a kayak. Reviewed

Japanese Journal of Clinical Biomechanics 35 297 - 302 2014.9

Language：Japanese Publishing type：Research paper (scientific journal)

当院における人口股関節置換術の検討 Reviewed

柏木輝行, 矢野良英, 花堂祥治, 小島岳史, 帖佐悦男

宮崎県医師会医学会誌 38 ( 2 ) 69 - 72 2014.9

Language：Japanese Publishing type：Research paper (scientific journal)

足底腱膜演 Invited Reviewed

河原勝博, 帖佐悦男

臨床スポーツ医学 31 ( 7 ) 623 - 627 2014.7

Language：Japanese Publishing type：Research paper (scientific journal)

春シーズンに開催されたラグビー競技会で発生した熱中症の2例 Reviewed

山口洋一朗, 山口奈美, 田島卓也, 帖佐悦男

九州・山口スポーツ医・科学研究会誌 26 100 - 102 2014.7

Language：Japanese Publishing type：Research paper (scientific journal)

Os acromialeを伴った腱板断裂に対する鏡視下腱板修復，Os acromiale切除術 Reviewed

石田康行, 帖佐悦男, 谷口昇, 田島卓也, 山口奈美, 大田智美, 中村志保子

JOSKAS 39 ( 3 ) 564 - 568 2014.6

Language：Japanese Publishing type：Research paper (scientific journal)

Load-transfer analysis after insertion of cementless anatomical femoral stem using pre- and post-operative CT images based patient-specific finite element analysis. Reviewed

Yamako G, Chosa E, Zhao X, Totoribe K, Watanabe S, Sakamoto T, Nakane N.

Medical Engineering & Physics 36 ( 6 ) 694 - 700 2014.6

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.medengphy.2014.02.018

Comprehensive Safety Manegement and Assessment at Rugby Football Competitions. Reviewed

Tajima T, Chosa E, Kawahara K, Nakamura Y, Yoshikawa D, Yamaguchi N, Kashiwagi T.

International Journal of sports medicine 2014.5

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1055/s-0034-1372634

後上方型腱板断裂に対する鏡視下手術 Invited Reviewed

石田康行, 帖佐悦男

Monthly Book Orthopaedics 27 ( 5 ) 21 - 27 2014.5

Language：Japanese Publishing type：Research paper (scientific journal)

発育期のスポーツ障害－整形外科系 Invited Reviewed

帖佐悦男

日医雑誌 143 ( 2 ) 279 - 282 2014.5

Language：Japanese Publishing type：Research paper (scientific journal)

少年野球検診におけるフィードバック方法の改良　過去の反省から Reviewed

石田康行, 帖佐悦男, 河原勝博, 長澤誠

日本整形外科スポーツ医学会雑誌 34 ( 2 ) 211 - 214 2014.5

Language：Japanese Publishing type：Research paper (scientific journal)

Surface-holding repair: an original arthroscopic rotator cuff repair technique. Reviewed

Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Araki N, Chosa E.

Journal of Shoulder and Elbow Surgery 23 ( 5 ) 620 - 627 2014.5

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jse.2014.01.007

子どもからのロコモ予防の重要性－運動器検診を通して－ Invited Reviewed

山口奈美, 山本惠太郎, 河原勝博, 石田康行, 田島卓也, 帖佐悦男

日本臨床スポーツ医学会誌 22 ( 2 ) 250 - 253 2014.4

Language：Japanese Publishing type：Research paper (scientific journal)

Prevention of the Cervical Degenerative Changes in Rugby Football Players:The Effect of Core Muscle Strength Exercise Reviewed

Japanese Journal of ORTHOPAEDIC SPORTS MEDICINE 34 ( 1 ) 80 - 84 2014.3

Language：Japanese Publishing type：Research paper (scientific journal)

前十字靭帯不全膝における半月縫合術の成績 Reviewed

森田雄大, 河原勝博, 田島卓也, 山口奈美, 矢野浩明, 石田康行, 村上恵美, 大田智美, 中村志保子, 大塚記史, 帖佐悦男

整形外科と災害外科 63 ( 2 ) 260 - 262 2014.3

Language：Japanese Publishing type：Research paper (scientific journal)

ハムストリング腱を用いた2重束ACL再建術後の膝固定期間の相違と骨孔拡大の関係 Reviewed

田島卓也, 石田康行, 山口奈美, 帖佐悦男, 山本惠太郎

JOSKAS　日本関節鏡・膝・スポーツ整形外科学会雑誌 39 170 - 171 2014.3

Language：Japanese Publishing type：Research paper (scientific journal)

Pseudoaneurysm as a complication of shoulder arthroscopy Reviewed

Yasuyuki Ishida,Ethuo Chosa,Noboru Taniguchi

Knee Surgery, Sports Traumatology, Arthroscopy 2014.3

Language：English Publishing type：Research paper (scientific journal)

宮崎県における関節リウマチに対する生物学的製剤の使用実態調査～第2報～ Reviewed

濱田浩朗, 梅北邦彦, 岡山昭彦, 日高利彦, 甲斐睦章, 上田章, 税所幸一郎, 村井幸一, 大平卓, 松山幹太郎, 金井一男, 坂田師通, 佐々木隆, 岡本将幸, 安藤徹, 秋元正樹, 首藤敏秀, 三股恒夫, 田中弦一, 松本英裕, 吉永一春, 谷口博信, 福田健二, 川野啓一郎, 木屋博昭, 市原正彬, 谷畠満, 佐保修二, 宮本義明, 帖佐悦男

宮崎県医師会医学会誌別冊 38 ( 1 ) 26 - 33 2014.3

Language：Japanese Publishing type：Research paper (scientific journal)

Measures to Prevent Locomotive Syndrome in Childhood: Why We Must Act Reviewed

51 ( 2 ) 113 - 119 2014.2

Language：Japanese Publishing type：Research paper (scientific journal)

Two siblings with neuropathic scoliosis caused by Chiari malformation type I with syringomyelia. Reviewed

Kuroki H, Inomata N, Hamanaka H, Higa K, Chosa E, Tajima N.

Journal of orthopaedic science 2014.1

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00776-013-0520-0

石田康行, 帖佐悦男, 矢野浩明, 谷口昇, 大田智美, 中村志保子, 大塚記史

肩関節 38 ( 2 ) 532 - 536 2014

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Shoulder Society

　鏡視下腱板修復術はsuture bridge（SB）法へと進化してきた．われわれもSB法を導入し腱板の整復を意識した修復を行っている．今回，滑液包側にknotがでないSB法群（－群），knotがでるSB法群（＋群）の臨床成績，腱板修復状態，術後肩峰下骨形態を検討したので報告する．－群29肩，＋群20肩を対象とした．両群間で性差，年齢，断裂形態に有意差はなかった．臨床成績を術前，術後1年時のJOA scoreで，腱板修復状態を術後1年時MRIで評価した．肩峰下骨形態は術後1年時CTで，一部が浸食されたimpingement type，腱板の形に適合したcongruity type，変化がないnormal typeに分類し評価した．臨床成績は－群，術前平均60.1点が術後平均92.9点へ，＋群，術前平均63.1点が術後平均94.4点へと有意に改善した．腱板修復状態は再断裂率が－群，21%，+群25%であった．肩峰下骨形態は－群でcongruity type，＋群でimpingement type，congruity typeの割合が高かった．臨床成績，腱板修復状態は概ね良好であった．肩峰下骨形態に関してはknotの有無，糸の質が影響していた．

DOI： 10.11296/katakansetsu.38.532

Quadrilateral spaceへの骨棘による腋窩神経障害が原因と考えられた肩甲骨体部骨折後遺残痛の一例

大塚記史, 石田康行, 矢野浩明, 谷口昇, 大田智美, 中村志保子, 帖佐悦男

肩関節 38 ( 2 ) 496 - 498 2014

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Shoulder Society

　肩甲骨骨折後遺残痛の原因がquadrilateral spaceへの骨棘と考えられ，骨棘切除にて疼痛が消失した一例であった．症例は49歳，男性．通勤労災事故で右肩甲骨体部骨折を受傷した．近医で保存療法され骨癒合したが右肩痛が残存した．受傷後13ヶ月後，鏡視下デブリドマン施行，術後右肩痛軽快したが特定の肢位での疼痛，右肩外側への放散痛を認めた．CTでquadrilateral spaceへの骨棘を認めた．受傷22ヶ月後，観血的骨棘切除術施行し，術後直後，右肩痛は消失した．

DOI： 10.11296/katakansetsu.38.496

314 Initial Stability and Strain Distribution of Cementless Hip Stems as a Function of Stem Design

ABE Junichi, OUCHI Koki, YAMAKO Go, GANG Deng, TOTORIBE Koji, CHOSA Etsuo

2014 ( 67 ) "314 - 1"-"314-2" 2014

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers

In-vitro biomechanical evaluation of stress shielding and initial stability of a low-modulus hip stem made of β type Ti-33.6Nb-4Sn alloy

Yamako G., Chosa E., Totoribe K., Hanada S., Masahashi N., Yamada N., Itoi E.

Medical Engineering and Physics 36 ( 12 ) 1665 - 1671 2014

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Medical Engineering and Physics

© 2014 IPEM.Stress shielding-related proximal femoral bone loss after total hip arthroplasty occurs because of the different stiffness of metallic alloy stems and host bone. To overcome this, we fabricated a low-modulus cementless hip stem from β-type Ti-33.6Nb-4Sn alloy (TNS). Then we evaluated its stiffness, stress shielding, and initial stability compared with a similar Ti-6Al-4V alloy stem. Stiffness was determined by axial compression and cantilever-bending tests. Thirteen triaxial strain gages measured cortical strain. Stress shielding was defined as the percentage of intact strain after stem insertion. To evaluate initial stability, displacement transducers measured axial relative displacement and rotation. Intact and implanted femurs underwent single-leg-stance loading. Axial stiffness was 56% lower in the TNS stem than in the Ti-6Al-4V stem, and bending stiffness of the TNS stem decreased gradually from the proximal region to the distal region, being ≤53% that of the Ti-6Al-4V stem, indicating gradation of Young's modulus. The TNS stem decreased stress shielding in the proximal calcar region (A1: 83%, B1: 85% relative to intact cortical strain) without affecting the proximal lateral region (B3: 53%). The initial stabilities of the stems were comparable. These findings indicate that the TNS stem with gradation of Young's modulus minimizes proximal femoral bone loss and biological fixation, improving long-term stability.

DOI： 10.1016/j.medengphy.2014.09.002

Evaluation of stress shielding for three types of implanted femurs based on stress distribution

肘頭骨端線閉鎖不全に対する骨移植術の工夫 Reviewed

石田康行、帖佐悦男、矢野浩明、山口奈美、大田智美、中村志保子

日本肘関節学会雑誌 20 ( 2 ) 122 - 124 2013.12

Language：Japanese Publishing type：Research paper (scientific journal)

Effect of Acetabular Reinforcement Ring With Hook for Acetabular Dysplasia Clarified by Three-Dimensional Finite Element Analysis Reviewed

Xin Zhao, Etsuo Chosa, GoYamako, Shinji Watanabe, Gang Deng, Koji Totoribe

The Journal of Arthroplasty 28 1765 - 1769 2013.12

Language：English Publishing type：Research paper (scientific journal)

Relationship between Muscle Activity in the Shoulder Girdle Area and Trunk Rotation during Pitching Reviewed

28 ( 6 ) 703 - 708 2013.12

Language：Japanese Publishing type：Research paper (scientific journal)

Ouchi K., Deng G., Yamako G., Chosa E., Nakanishi T.

Applied Mechanics and Materials 459 524 - 529 2013.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Applied Mechanics and Materials

This research investigates the stress distribution of the three types of implanted femurs using the finite element method analysis. The comparisons of the stress distribution between the implanted femursand the healthy femur were performed and the characteristics in the stress shielding of each casewere clarified. Since the load is transferred on the contact surface between the implant and the inner surface of the femur in the case of the total hip arthroplasty, the stress in the intertrochanteric zone (Gruen zone 7) become very small, and the phenomenon of the stress shielding is confirmed obviously. The stress distributions of the femurs afterthe resurfacing hiparthroplasty and the thrust plate prosthesis are about the same with that of the healthy femur, so, the possibility of the stress shielding is considered lower compared with the femur after the total hip arthroplasty. However, considering the stress concentration thatwill increase the risk of femoral fracture caused by the screws for the fixation of the implant in the thrust plate prosthesis, the resurfacing hiparthroplastymay beconcluded as the best method among these three types of implants to avoid stress shielding. © (2014)Trans Tech Publications,Switzerland.

DOI： 10.4028/www.scientific.net/AMM.459.524

足底部の血管奇形に対して硬化療法施行後に切除術を行った1例

Operative indication and procedure for postero-superior rotator cuff tear Reviewed

11 711 - 716 2013.10

Language：Japanese Publishing type：Research paper (scientific journal)

関節リウマチ診療における超音波検査の注意点 Reviewed

濱田浩朗, 帖佐悦男, 梅北邦彦, 岡山昭彦

九州リウマチ 33 ( 2 ) 64 - 67 2013.9

Language：Japanese Publishing type：Research paper (scientific journal)

足底部の血管奇形に対して硬化治療施行後に切除術を行った1例 Reviewed

大塚記史, 坂本武郎, 関本朝久, 渡邊信二, 濱田浩朗, 榮建文, 池尻洋史, 中村嘉宏, 小牧亘, 舩元太郎, 梅崎哲矢, 日吉優, 李徳哲, 帖佐悦男

整形外科と災害外科 62 ( 3 ) 623 - 625 2013.9

Language：Japanese Publishing type：Research paper (scientific journal)

咽後膿瘍が疑われた石灰沈着性頚長筋炎の一例 Reviewed

森田雄大, 黒木浩史, 濱中秀昭, 猪俣尚規, 増田寛, 帖佐悦男

整形外科と災害外科 62 ( 3 ) 532 - 535 2013.9

Language：Japanese Publishing type：Research paper (scientific journal)

幼小児側弯症に対するgrowing rod法の経験 Reviewed

黒木浩史, 猪俣尚規, 濱中秀昭, 増田寛, 森田雄大, 帖佐悦男

整形外科と災害外科 62 ( 3 ) 421 - 425 2013.9

Language：Japanese Publishing type：Research paper (scientific journal)

大塚記史, 坂本武郎, 関本朝久, 渡邊信二, 濱田浩朗, 榮建文, 池尻洋史, 中村嘉宏, 小牧亘, 舩元太郎, 梅崎哲矢, 日吉優, 李徳哲, 帖佐悦男

整形外科と災害外科 62 ( 3 ) 623 - 625 2013.9

Language：Japanese Publishing type：Research paper (scientific journal)

Comparison of range of motion after arthroscopic rotator cuff repair between the continuous and the tenporary interscalene block Invited Reviewed

37 ( 2 ) 761 - 764 2013.9

Language：Japanese Publishing type：Research paper (scientific journal)

学校健診における運動器検診の普及に向けて－宮崎方式：なぜ子供の頃からロコモティブシンドローム予防が必要か・課題とその対策－ Reviewed

帖佐悦男, 山口奈美, 河原勝博, 山本惠太郎

日本臨床スポーツ医学会誌 3 ( 21 ) 574 - 580 2013.8

Language：Japanese Publishing type：Research paper (scientific journal)

ラグビー選手における頚椎退行変性の予防－頚部体幹コアトレーニング導入の効果－ Reviewed

田島卓也, 帖佐悦男, 河原勝博, 山口奈美, 中村嘉宏

日本整形外科スポーツ医学会雑誌 34 80 - 84 2013.8

Language：Japanese Publishing type：Research paper (scientific journal)

Medical Checkup for Child and Adolescent Baseball Players in Miyazaki Reviewed

33 ( 1 ) 7 - 11 2013.8

Language：Japanese Publishing type：Research paper (scientific journal)

学校健診における運動器検診の普及に向けて : 宮崎方式:なぜ子供の頃からロコモティブシンドローム予防が必要か・課題とその対策

帖佐悦男, 山口奈美, 河原勝博, 山本惠太郎

日本臨床スポーツ医学会誌 = The journal of Japanese Society of Clinical Sports Medicine 21 ( 3 ) 574 - 580 2013.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本臨床スポーツ医学会

宮崎県国体少年男子サッカーチームに対するメディカルサポート Reviewed

日吉優, 樋口潤一, 小島岳史, 山口奈美, 永井琢哉, 宮本浩幸, 原田昭彦, 帖佐悦男

九州・山口スポーツ医・科学研究会誌 ( 25 ) 40 - 43 2013.8

Language：Japanese Publishing type：Research paper (scientific journal)

Distal Biceps Tendon Reconstruction for Rugby Football Player Using Autologous Hamstring Graft and EndoButton Technique:A Case Report Reviewed

33 ( 3 ) 321 - 326 2013.7

Language：Japanese Publishing type：Research paper (scientific journal)

Segmental Copy Number Loss in the Region of Semaphorin 4D Gene in Patiants with Acetabular Dysplasia Reviewed

Tomohisa Sekimoto, Miho Isii, Mitsuru Emi, Syuji Kurogi, Taro Funamoto, Hiroaki Hamada, Etsuo Chosa

Journal of Orthopaedic Research 31 ( 6 ) 957 - 961 2013.6

Language：English Publishing type：Research paper (scientific journal)

Segmental copy number loss in the region of Semaphorin 4D gene in patients with acetabular dysplasia

Sekimoto T., Ishii M., Emi M., Kurogi S., Funamoto T., Hamada H., Chosa E.

Journal of Orthopaedic Research 31 ( 6 ) 957 - 961 2013.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Research

Acetabular dysplasia (AD) appears to be a multi-factorial disease, which may involve both genetic and environmental factors and whose pathogenesis remains obscure. The present study aims to identify a genetic variation that might confer risk of AD. We performed whole-genome screening of a copy number variation (CNV) using a deCODE-Illumina CNV beadchip with 20 female AD patients and 131 control subjects. Subsequently, Agilent's region-targeted high-density oligonucleotide tiling microarray was used to analyze 64 female AD patients and 32 female control subjects. By sequential analyses, we found a copy number loss in 18 of 64 AD patients, but none in the 32 controls. The loss occurred within a 472 kb region on 9q22.2, which harbors the gene for Semaphorin 4D (Sema4D; 18/64 vs. 0/32, p = 4.81 × 10-4, OR = 25.86). We suggest that a copy number loss of the Sema4D gene region may play a role in the etiology of AD. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

DOI： 10.1002/jor.22310

Three cases tibialplateau fractures and nonunion of tibial shaft fracture treated with TKA

Growing rod 法にて治療したvon Recklinghausen病による症候群性側弯症の1例 Reviewed

黒木浩史, 猪俣尚規, 濱中秀昭, 増田寛, 戚美玲, 帖佐悦男

Journal of Spine Research 4 ( 5 ) 941 - 945 2013.5

Language：Japanese Publishing type：Research paper (scientific journal)

Three cases tibialplateau franctures and nonunion of tibial shaft fracture treated with TKA Reviewed

38 ( 2 ) 244 - 245 2013.4

Language：Japanese Publishing type：Research paper (scientific journal)

BTBと薄筋腱を併用した2重束ACL再建術 Reviewed

田島卓也, 山本惠太郎, 河原勝博, 石田康行, 山口奈美, 大田智美, 帖佐悦男

JOSKAS　日本関節鏡・膝・スポーツ整形外科学会雑誌 38 54 - 55 2013.4

Language：Japanese Publishing type：Research paper (scientific journal)

KOJIMA Takeshi

38 ( 2 ) 244 - 245 2013.4

Language：Japanese Publishing type：Research paper (scientific journal)

非定型大腿骨骨折の治療経験 Reviewed

小牧ゆか、小牧宏和、小牧一麿、帖佐悦男

整形外科と災害外科 62 ( 2 ) 312 - 315 2013.3

Language：Japanese Publishing type：Research paper (scientific journal)

膝外側円板状半月に合併した大腿骨内顆離断性骨軟骨炎の治療経験 Reviewed

山口奈美、山本惠太郎、石田康行、河原勝博、田島卓也、大田智美、帖佐悦男

Journal of Japanese Orthopaedic Society of Knee, Arthroscopy and Sports Medicine 38 ( 1 ) 150 - 151 2013.3

Language：Japanese Publishing type：Research paper (scientific journal)

ＢＴＢと薄筋腱を併用した２重束ＡＣＬ再建術 Reviewed

田島卓也、山本惠太郎、河原勝博、石田康行、山口奈美、大田智美、帖佐悦男

Journal of Japanese Orthopaedic Society of Knee, Arthroscopy and Sports Medicine 38 ( 1 ) 54 - 55 2013.3

Language：Japanese Publishing type：Research paper (scientific journal)

鏡視下腱板修復術後における非吸収性アンカー孔の検討 Reviewed

石田康行、帖佐悦男、山本惠太郎、田島卓也、山口奈美、大田智美

Journal of Japanese Orthopaedic Society of Knee, Arthroscopy and Sports Medicine 38 ( 1 ) 16 - 17 2013.3

Language：Japanese Publishing type：Research paper (scientific journal)

高齢者の大腿骨頚部骨折に対する骨接合術の治療成績　～成績不良例の検討～ Reviewed

吉川大輔、園田典生、田邊龍樹、帖佐悦男

整形外科と災害外科 62 ( 2 ) 285 - 290 2013.3

Language：Japanese Publishing type：Research paper (scientific journal)

高齢者の大腿骨頚部骨折に対する骨接合術の治療成績 : 成績不良例の検討

吉川大輔, 園田典生, 田邊龍樹, 帖佐悦男

整形外科と災害外科 62 ( 2 ) 285 - 290 2013.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

60歳以上の大腿骨頚部骨折に対して骨接合術を施行した症例の治療成績ならびに成績不良因子に関し検討した．2007年1月から2011年12月までに行った症例のうち術後3カ月以上観察できた24例を対象とした．男性7例，女性17例で，手術は全例ハンソンピンを用いて行った．手術時平均年齢は80.3歳（60歳～99歳），骨折型はGarden分類でStage I：5例，II：10例，III：6例，IV：3例であった．これらの症例に対し，再手術率，術後合併症，術後のGarden alignment index（GAI），ピン刺入位置，telescoping量について検討した．骨癒合率は79.1％（Stage I：100％，II：100％，III：50％，IV：33％）で，術後合併症は偽関節5例，late segmental collapse 1例であった．再手術率は12.5％（3例）であった．成績不良因子は骨折型，ピン刺入位置，telescoping量であった．治療成績向上のために，technical errorを最小限に抑えること，術前評価を的確に行い手術法を選択することが重要と考えられた．

DOI： 10.5035/nishiseisai.62.285

当科における化膿性脊椎炎の検討 Reviewed

猪俣尚規、黒木浩史、濱中秀昭、増田寛、樋口誠二、深尾悠、大塚記史、帖佐悦男

整形外科と災害外科 62 ( 1 ) 5 - 8 2013.3

Language：Japanese Publishing type：Research paper (scientific journal)

宮崎県における少年野球検診の実際 Reviewed

石田康行、帖佐悦男、長澤誠

Japanese Journal of Orthopaedic sports medicine 33 ( 1 ) 7 - 11 2013.3

Language：Japanese Publishing type：Research paper (scientific journal)

A diclofenac suppository-nabumetone combination therapy for arthritic pain relief and a monitoring method for the diclofenac binding capacity of HSA site II in rheumatoid arthritis

Setoguchi N., Takamura N., Fujita K., Ogata K., Tokunaga J., Nishio T., Chosa E., Arimori K., Kawai K., Yamamoto R.

Biopharmaceutics and Drug Disposition 34 ( 2 ) 125 - 136 2013.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biopharmaceutics and Drug Disposition

Diclofenac suppository, a non-steroidal anti-inflammatory drug (NSAID), is used widely in rheumatoid arthritis (RA) patients with severe arthritic pain. As the binding percentage of diclofenac to serum proteins is high, its free (unbound) concentration after rectal administration is low. To increase temporarily the free concentration of diclofenac and to enhance its analgesic effect by inhibiting the protein binding of diclofenac, the analgesic effect of diclofenac was examined before and after the start of an inhibitor administration to RA patients with insufficient control of arthritic pain, and the protein binding capacity of diclofenac was evaluated. Binding experiments were performed by ultrafiltration, and arthritic pain was recorded by the face scale. Free fractions of diazepam and diclofenac were augmented by increasing 6-methoxy-2-naphthylacetic acid (6-MNA; the active metabolite of the NSAID nabumetone) concentrations. The free fraction of diazepam increased after the start of nabumetone administration to RA patients, and arthritic pain relief was observed. These results suggest that 6-MNA has an inhibitory effect on the protein binding of diclofenac and the free fraction of diazepam can be used to evaluate the binding capacity of diclofenac. It is considered that diclofenac suppository-nabumetone combination therapy and the method for protein binding monitoring by diazepam can positively benefit RA patients with insufficient control of arthritic pain. Copyright © 2013 John Wiley & Sons, Ltd. Copyright © 2013 John Wiley & Sons, Ltd.

DOI： 10.1002/bdd.1829

Nonlinear stress analysis of the supraspinatus tendon using three-dimensional finite element analysis

A diclofenac suppository-nabumetone combination therapy for arthritic pain relief and a monitoring method for the diclofenac binding capacity of HSA site II in rheumatoid arthritis. Reviewed

Setoguchi N, Takamura N, Fujita K, Ogata K, Tokunaga J, Nishio T, Chosa E, Arimori K, Kawai K, Yamamoto R.

Biopharmaceutics & Drug Disposition 34 ( 2 ) 125 - 136 2013.1

Language：English Publishing type：Research paper (scientific journal)

Inoue A., Inoue A., Chosa E., Goto K., Tajima N.

Knee Surgery, Sports Traumatology, Arthroscopy 21 ( 5 ) 1151 - 1157 2013

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Knee Surgery, Sports Traumatology, Arthroscopy

Purpose: No studies have used stress analysis with finite element analysis (FEA) to determine the causes of and mechanisms underlying rotator cuff tears. Therefore, we performed a biomechanical evaluation of the changes in stress distribution on the rotator cuff using three-dimensional (3-D) FEA. Methods: The 3-D FEA model of shoulder joint allowed for abduction angles of 0°, 45° and 90° from the plane of the scapula and included the anatomical insertion points of the three major rotator cuff tendons and the middle fibres of the deltoid muscle. Stress distribution of the supraspinatus tendon on 3-D FEA was validated by a comparison with cadaveric and two-dimensional finite element model. Results: The principal stress peaked in the region approximately 1 cm proximal to the insertion of the supraspinatus tendon. Furthermore, the stress on the joint side increased at the anterior edge of the supraspinatus tendon at abduction angles of 45° and 90°. Conclusion: There are differences in stress changes between the joint side and bursal side of the supraspinatus tendon within the angles of abduction. The maximal tensile stress was observed on the articular side of the anterior edge of the supraspinatus tendon at 90° abduction. Our results indicate that the difference in tensile stress between the two layers results in delamination and causes partial-thickness tears. Level of evidence: Decision analysis, Level II. © 2012 Springer-Verlag.

DOI： 10.1007/s00167-012-2008-4

Locomotive Syndrome, Musculoskeletal Ambulation Disorder Symptom Complex, Frailty and Sarcopenia:Prevention and Rehabilitation

CHOSA Etsuo

The Japanese Journal of Rehabilitation Medicine 50 ( 1 ) 48 - 54 2013

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association of Rehabilitation Medicine

As Japan has become a super-aging society a new focus has been placed on locomotive syndrome (Locomo), musculoskeletal ambulation disorder symptom complex (MADS), frailty and sarcopenia. Locomo is a condition whereby long-term care or support is needed or may be needed in the future due to weakness of the locomotive organs. MADS is a condition presenting with unstable balance or walking difficulty, which leads to a high risk of the patient falling down or giving up excursions outside the home. In a broad sense, MADS patients also belong in the Locomo category. The prevention and treatment of Locomo and MADS are very important, because these conditions typically result in deterioration of the exercise function and loss of mental and physical health. The aim of Locomotive syndrome exercises is to reduce pain, and to restore and improve joint function. We need to take a comprehensive approach to Locomotive syndrome, including lifestyle modification, muscle exercise, stretching and therapeutic exercise. Two basic, simple and commonly used exercises are single-leg standing and squats exercises.

DOI： 10.2490/jjrmc.50.48

Single-group study to explore the optimal management of neuropathic acoliosis caused by neural axis abnormalities based on its clinical features Reviewed

Hiroshi Kuroki, Naoki Inomata, Hideaki Hamanaka, Etsuo Chosa, Naoya Tajima

The Open Spine Journal 4 28 - 33 2012.12

Language：English Publishing type：Research paper (scientific journal)

脊柱側弯症に対する後方矯正固定術におけるinstrumentation failureの検討 Reviewed

黒木浩史、猪俣尚規、濱中秀昭、増田寛、樋口誠二、川野啓介、李徳哲、帖佐悦男　　

Journal of Spine Research 3 ( 12 ) 1604 - 1609 2012.12

Language：Japanese Publishing type：Research paper (scientific journal)

変形性膝関節症に対するヒアルロン酸製剤の維持投与療法の有効性　－前向き多施設共同比較試験－ Reviewed

廣瀬隼、水田博志、片岡晶志、津村弘、渡邊信二、帖佐悦男

整形外科 63 ( 13 ) 1321 - 1326 2012.12

Language：Japanese Publishing type：Research paper (scientific journal)

Single-group study to explore the optimal management of neuropathic scoliosis caused by neural axis abnormalities based on its clinical features

Kuroki H., Inomata N., Hamanaka H., Chosa E., Tajima N.

Open Spine Journal 4 ( 1 ) 28 - 33 2012.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Open Spine Journal

Although it is not easy to differentiate neuropathic scoliosis caused by neural axis abnormalities (NAAs) from idiopathic scoliosis for lack of neurological signs, neuropathic scoliosis caused by NAAs has some specific clinical findings. The purpose of this study was to investigate the characteristics of neuropathic scoliosis caused by NAAs and to discuss the essential points of diagnosis and treatment. From 1998 through 2008, 622 new patients visited our scoliosis outpatient clinic. Of those, 12 patients with neuropathic scoliosis caused by NAAs diagnosed by cervical MRI were involved in this study. They included 5 boys and 7 girls with a mean age of 10 years and 5 months. We investigated the relationship of NAAs, treatment methods for scoliosis, and effects of neurosurgical treatment for prognosis of outcome. There were 10 cases of syringomyelia with Chiari malformation type I, 1 case of syringomyelia alone, and 1case of spinal cord tumor. Surgery was performed in 3 cases, an under arm brace was prescribed in 6 cases, and observation was selected in 3 cases. Scoliotic curves were improved in 4 out of the 11 cases on whom neurosurgical intervention for the relationship of NAAs were performed. The Cobb angles before surgery of these 4 cases were less than 30° and 3 of the 4 cases were 8 years old or less. We would emphasize that early treatment for the relationship of NAAs at younger age (≤8 yrs) and before curve progression (<30°) should be actively enforced for favorable prognosis of neuropathic scoliosis caused by NAAs. © Kuroki et al.; Licensee Bentham Open.

DOI： 10.2174/1876532701204010028

Use of 2-Octyl Cyanoacrylate (Dermabond HV) for Skin Closure in Cervical Laminoplasty

当科側弯症外来における脊柱側弯症初診時進行例　－初診時Cobb角50°以上の症例での検討－ Reviewed

黒木浩史、猪俣尚規、帖佐悦男、田島直也

Journal of Spine Research 3 ( 11 ) 1426 - 1429 2012.11

Language：Japanese Publishing type：Research paper (scientific journal)

有限要素法による人工股関節置換術のバイオメカニクス研究 Reviewed

山子剛、帖佐悦男、鳥取部光司、趙昕、坂本武郎

整形・災害外科 55 ( 11 ) 1365 - 1374 2012.10

Language：Japanese Publishing type：Research paper (scientific journal)

アナトミカル型セメントレス・ステムにおける荷重伝達様式の術後評価　～術前・術後CT画像に基づいた患者別有限要素解析～ Reviewed

山子剛、帖佐悦男、趙昕、鳥取部光司

臨床バイオメカニクス 33 271 - 278 2012.10

Language：English Publishing type：Research paper (scientific journal)

TSB下腿義足とPTB下腿義足の接触圧力解析 Reviewed

鳥取部光司、帖佐悦男、趙昕、山子剛、渡邊信二、鄧鋼

臨床バイオメカニクス 33 423 - 426 2012.10

Language：English Publishing type：Research paper (scientific journal)

頚椎椎弓形成術手術創に対するダーマボンドRHVの使用経験 Reviewed

増田寛、黒木浩史、濱中秀昭、猪俣尚規、樋口誠二、川野啓介、李徳哲、帖佐悦男

整形外科と災害外科 61 ( 3 ) 506 - 508 2012.9

Language：Japanese Publishing type：Research paper (scientific journal)

MASUDA Hiroshi, KUROKI Hiroshi, HAMANAKA Hideaki, INOMATA Naoki, HIGUCHI Seiji, KAWANO Keisuke, LEE DeogChoel, CHOSA Etsuo

Orthopedics & Traumatology 61 ( 3 ) 506 - 508 2012.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

To compare the efficacy of 2-octylcyanoacrylate (Dermabond; Ethicon Inc) with standard suture repair in the management of cervical laminoplasty. Fourty-five patients were enrolled in this study. Twenty-two patients were using Dermabond, and 23 were repaired using standard suture. All patients underwent surgery in 2010 and were observed three months or more after operation. Operation time, prone position time, incision length, intraoperative blood loss, days of drain and gauze removal and times to replace the gauze were examined. There were no adverse events in both groups. Significant difference in operation and prone position time, intraoperative blood loss, days of drain removal were not observed. The average days required for gauze removal using Dermabond was 6.73 days, which was significantly less than that required for suture repair (11.87 days) (p<0.05). And the average number of times to replace the gauze using Dermabond was 3.86, which was significantly less than that required for suture repair (5.22 times) (p<0.05). In the management of cervical laminoplasty, Dermabond is an effective repair technique.

DOI： 10.5035/nishiseisai.61.506

宮崎県における関節リウマチに対する生物学的製剤の使用実態調査～第１報～ Reviewed

梅北邦彦　濱田浩朗　岡山昭彦　日高利彦　甲斐睦章　上田章　税所幸一郎　村井幸一　大平卓　松山幹太郎　坂田師通　佐々木隆　岡本将幸　安藤徹　秋元正樹　首藤敏秀　黒沢冶　田中弦一　松本英裕　吉永一春　谷口博信　福田健二　川野啓一郎　木屋博昭　市原正彬　谷畠満　佐保修二　宮本義明　帖佐悦男

宮崎県医師会医学会誌 36 ( 2 ) 172 - 180 2012.9

Language：Japanese Publishing type：Research paper (scientific journal)

学校における運動器検診の役割と実際　－宮崎県の場合－ Reviewed

帖佐悦男、山本惠太郎、山口奈美

臨床スポーツ医学 29 15 - 21 2012.9

Language：Japanese Publishing type：Research paper (scientific journal)

手術適応厳選前後の鏡視下腱板修復術の成績 Reviewed

石田康行、矢野浩明、山本惠太郎、河原勝博、田島卓也、山口奈美、大田智美、中村志保子、帖佐悦男

整形外科と災害外科　別冊 61 ( 3 ) 346 - 349 2012.9

Language：Japanese Publishing type：Research paper (scientific journal)

鏡視下腱板修復術後の腱板修復状態と可動域推移の関係 Reviewed

石田康行、帖佐悦男、矢野浩明、大田智美、中村志保子

肩関節 36 ( 2 ) 511 - 514 2012.8

Language：Japanese Publishing type：Research paper (scientific journal)

Ｅｆｆｅct of genu recurvatum on the anterior cruciate ligament-deficient knee during gait Reviewed

Katsuhiro Kawahara,Tomohisa Sekimoto,Shinji Watanabe,Keitaro Yamamoto,Takuya Tajima,Nami Yamaguchi, Etsuo Chosa

Knee Surgery, Sports Traumatology, Arthroscopy 20 ( 8 ) 1479 - 1487 2012.8

Language：English Publishing type：Research paper (scientific journal)

Ｍenisｃo Capsular Separationに対する鏡視下半月縫合術の検討 Reviewed

小島岳史、花堂祥治、矢野良英、柏木輝行、塩﨑猛、田島卓也、帖佐悦男

九州・山口スポーツ医・科学研究会誌 24 89 - 92 2012.8

Language：Japanese Publishing type：Research paper (scientific journal)

関節リウマチ膝滑液包炎にリンパ管腫を合併した１例 Reviewed

濱田浩朗、帖佐悦男、税所幸一郎

日本関節病学会誌 31 ( 2 ) 147 - 151 2012.7

Language：English Publishing type：Research paper (scientific journal)

鏡視下腱板修復術後における吸収性アンカー孔の拡大 Reviewed

石田康行、山本惠太郎、田島卓也、山口奈美、大田智美、帖佐悦男

Journal of Japanese Orthopaedic Society of knee, Arthroscopy and Sports Medicine 37 ( 3 ) 391 - 394 2012.6

Language：Japanese Publishing type：Research paper (scientific journal)

当科における体外衝撃波治療の経験 Reviewed

河野勝博、帖佐悦男、﨑濵智美、長澤誠、川野啓介、永井琢哉、宮元修子

宮崎整形外科懇話会論文集 ( 16 ) 1 - 2 2012.6

Language：Japanese Publishing type：Research paper (scientific journal)

Menisco Capsular Separation に対する鏡視下半月縫合術の検討 Reviewed

小島岳史、花堂祥冶、矢野良英、柏木輝行、田島卓也、帖佐悦男

宮崎整形外科懇話会論文集 ( 16 ) 43 - 44 2012.6

Language：Japanese Publishing type：Research paper (scientific journal)

肘関節部脂肪腫による後骨間神経麻痺を呈した１例 Reviewed

吉川大輔、園田典生、田邊龍樹、矢野浩明、帖佐悦男

宮崎整形外科懇話会論文集 ( 16 ) 27 - 28 2012.6

Language：Japanese Publishing type：Research paper (scientific journal)

Posterior occipito-axial fixation applied C2 laminar screws for pediatric atlantoaxial instability caused by Down syndrome: Report of 2 cases Reviewed

Hiroshi Kuroki, Shinichiro Kubo, Hideaki Hamanaka, Etsuo Chosa

International Journal of Spine Surgery 6 210 - 215 2012.6

Language：English Publishing type：Research paper (scientific journal)

ラグビ―競技会における医療体制向上と重症事故発生予防を目的とした安全度評価法の活用 Reviewed

田島卓也、帖佐悦男、山本惠太郎、中村嘉宏、山口奈美、柏木輝行

日本整形外科スポーツ医学会雑誌 32 ( 2 ) 35 - 40 2012.5

Language：Japanese Publishing type：Research paper (scientific journal)

80歳以上の脊椎疾患の治療戦略　当科における超高齢者の頚椎手術の術後成績 Reviewed

濱中秀昭、黒木浩史、猪俣尚規、増田寛、黒木修司、菅田耕、樋口誠二、川野啓介、李德哲、帖佐悦男

Journal of Spine Research 3 ( 5 ) 761 - 764 2012.5

Language：Japanese Publishing type：Research paper (scientific journal)

変形性股関節症の原因としての股関節インピンジメント（Femoroacetabular Impingement : FAI）の概念と治療 Reviewed

帖佐悦男

臨床整形外科 47 ( 4 ) 307 - 314 2012.4

Language：Japanese Publishing type：Research paper (scientific journal)

膝複合靭帯修復・再建術症例の検討 Reviewed

田島卓也、山本惠太郎、石田康行、山口奈美、﨑濱智美、帖佐悦男

Journal of Japanese Orthopaedic Society of Knee, Arthroscopy and Sports Medicine 37 126 - 127 2012.4

Language：Japanese Publishing type：Research paper (scientific journal)

ロコモティブシンドロームの基礎疾患としての変形性関節症～虚弱（Frailty)との係わりも含めて～ Invited Reviewed

帖佐悦男

CLINICAL　CALCIUM 22 ( 4 ) 49 - 57 2012.4

Language：Japanese Publishing type：Research paper (scientific journal)

[Locomotive syndrome and frailty. Locomotive syndrome due to the underlying disease of degenerative arthritis].

Chosa E.

Clinical calcium 22 ( 4 ) 49 - 57 2012.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Clinical calcium

Japan became a superaging society. We have been putting a new focus on locomotive syndrome and frailty. The prevention and treatment of locomotive syndromes, such as osteoarthritis, degenerative spondylosis, lumbar canal stenosis, osteoporosis, upper extremity diseases, rheumatoid arthritis, and many other disorders of the locomotive organs are important. Because, the locomotive syndrome results in deterioration of the exercise function and loss of mental and physical health. The aim of locomotive syndrome exercises are: to reduce pain, to restore and improve joint function. We need to take a comprehensive approach to locomotive syndrome, including lifestyle modification, muscle exercise, stretching and therapeutic exercise.

Approach to the Management of Sports Injuries in Miyazaki Prefecture

ロコモティブシンドロームの基礎疾患としての変形性関節症～虚弱（Frailty)との係わりも含めて～ Invited Reviewed

帖佐悦男

CLINICAL CALCIUM 22 ( 4 ) 49(503) - 57(511) 2012.3

Language：Japanese Publishing type：Research paper (scientific journal)

Significance of hanging total spine x-ray to estimate the indicative correction angle by brace wearing in idiopathic scoliosis patients Reviewed

Hiroshi Kuroki, Naoki Inomata, Hideaki Hamanaka, Etsuo Chosa, Naoya Tajima

Scoliosis 7 ( 8 ) 2012.3

Language：English Publishing type：Research paper (scientific journal)

Arthroscopic anatomical double-bundle anterior cruciate ligament　reconstruction for Asian patient using a bone-patellar tendon-bone and gracilis　tendon composite autograft: a technical note Invited Reviewed

Takuya Tajima,Etsuo Chosa,Keitarou Yamamoto,Nami Yamaguchi

Sports Medicine, Arthroscopy,Rehabilitation, Therapy &Technology 4 ( 9 ) 2012.3

Language：English Publishing type：Research paper (scientific journal)

Adrenomedullin Concentration in the Cerebrospinal Fluid in Patients with Spinal Disease-Especially Adrenomedullin Production fron Schwannoma- Reviewed

Hamanaka H,Hiroshi K,Hiroaki H,Chosa E

Journal of Spine Research 3 ( 2 ) 140 - 143 2012.2

Language：English Publishing type：Research paper (scientific journal)

変形性膝関節症に対する運動療法 Invited Reviewed

帖佐悦男

BoneJointNerve 2 ( 1 ) 91 - 97 2012.1

Language：Japanese Publishing type：Research paper (scientific journal)

Nonlinear stress analysis of the supraspinatus tendon using three-dimensional element analysis Reviewed

Atsushi Inoue Etsuo Chosa Keisuke Goto Naoya Tajima

Knee Surgery, Sports Traumatology, Arthroscopy 20 ( 1 ) 2012.1

Language：English Publishing type：Research paper (scientific journal)

CHOSA Etsuo

The Journal of Japanese Physical Therapy Association 38 ( 8 ) 573 - 575 2011.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Physical Therapy Association (JPTA)

Effect of genu recurvatum on the anterior cruciate ligamaent-deficient knee during gait Reviewed

Katsuhiro Kawahara,Tomohisa Sekimoto,Shinji Watanabe,Keitaro Yamamoto,,Takuya Tajima,Nami Yamaguchi,Etsuo Chosa

Knee Surg Sports Traumatol Arthrosc 9 2011.11

Language：English Publishing type：Research paper (scientific journal)

脊髄疾患に起因した神経原性側弯症の検討 Reviewed

黒木浩史，猪俣尚規，帖佐悦男，田島直也

Journal of Spine Research 2 ( 11 ) 1805 - 1810 2011.11

Language：Japanese Publishing type：Research paper (scientific journal)

人工股関節置換術におけるサポートリングの応力解析 Reviewed

趙昕，帖佐悦男，鳥取部光司，渡邊信二，河原勝博，鄧鋼

臨床バイオメカニクス 32 365 - 369 2011.10

Language：Japanese Publishing type：Research paper (scientific journal)

人工股関節置換術におけるサポートリングの応力解析 Reviewed

趙昕、帖佐悦男、鳥取部光司、渡邊信二、河原勝博、鄧鋼

臨床バイオメカニクス 32 365 - 369 2011.10

Language：Japanese Publishing type：Research paper (scientific journal)

有限要素法を用いた人工股関節再置換術におけるステム固定性の検討 Reviewed

鳥取部光司，帖佐悦男，趙昕，渡邊信二，河原勝博，鄧鋼

臨床バイオメカニクス 32 371 - 375 2011.10

Language：Japanese Publishing type：Research paper (scientific journal)

反張膝が前十字靭帯再建術前後の歩行様式に与える影響 Reviewed

河原勝博，帖佐悦男，鳥取部光司，渡邊信二，石田康行，宮崎茂明，趙昕

臨床バイオメカニクス 32 377 - 383 2011.10

Language：Japanese Publishing type：Research paper (scientific journal)

投球動作における身体運動と肩甲帯周囲の筋活動特性 Reviewed

宮崎茂明，石田康行，鳥取部光司，河原勝博，帖佐悦男

臨床バイオメカニクス 32 167 - 172 2011.10

Language：Japanese Publishing type：Research paper (scientific journal)

アテトーゼ型脳性麻痺に伴った頚髄症の治療成績 Reviewed

黒木浩史，濱中秀昭，猪俣尚規，増田寛，福嶋秀一郎，帖佐悦男，久保紳一郎

Journal of Spine Research 2 ( 10 ) 1572 - 1577 2011.10

Language：Japanese Publishing type：Research paper (scientific journal)

Roles of the endoplasmic reticulum stress transducer OASIS in ｆracture healing Reviewed

Taro Funamoto,Tomohisa Sekimoto,Tomohiko Murakami,Syuji Kurogi,Kazunori Imaizumi,Etsuo Chosa

Bone 49 ( 4 ) 724 - 732 2011.10

Language：English Publishing type：Research paper (scientific journal)

Roles of the endoplasmic reticulum stress transducer OASIS in fracture healing.

Funamoto T, Sekimoto T, Murakami T, Kurogi S, Imaizumi K, Chosa E

Bone 49 ( 4 ) 724 - 32 2011.10

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bone.2011.06.012

E24 Acetabular Dysplasia Evaluation with Load-Displacement Characteristic

OUCHI Koki, DENG Gang, NAKANISHI Tsutomu, CHOUSA Etsuo

2011 153 - 154 2011.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers

大腿骨転子部骨折に対する120˚,125˚Gamma3Nailの比較 Reviewed

小島岳史，柏木輝行，花堂祥治，矢野良英，帖佐悦男

整形外科と災害外科 60 ( 3 ) 502 - 508 2011.9

Language：Japanese Publishing type：Research paper (scientific journal)

上腕骨骨頭に発生した軟骨芽細胞腫の１症例 Reviewed

宮元修子，矢野浩明，山本惠太郎，石田康行，田島卓也，山口奈美，﨑濵智美，長澤誠，帖佐悦男

整形外科と災害外科 60 ( 4 ) 692 - 696 2011.9

Language：Japanese Publishing type：Research paper (scientific journal)

鏡視下腱番修復術々後再断裂例の検討 Reviewed

石田康行，帖佐悦男，矢野浩明，山本惠太郎，河原勝博，田島卓也，山口奈美，﨑濵智美，長澤誠，川野啓介

整形外科と災害外科 60 ( 3 ) 373 - 377 2011.9

Language：Japanese Publishing type：Research paper (scientific journal)

馬尾症候群を呈した腰椎椎間板ヘルニアの検討 Reviewed

猪俣尚規，黒木浩史，濱中秀昭，増田寛，福嶋秀一郎，黒木修司，比嘉聖，樋口誠二，永井琢哉，久保紳一郎，帖佐悦男

整形外科と災害外科 60 ( 3 ) 440 - 445 2011.9

Language：Japanese Publishing type：Research paper (scientific journal)

A Study of Re-tear Cases after ARCR

ISHIDA Yasuyuki, CHOSA Etsuo, YANO Hiroaki, YAMAMOTO Keitaro, KAWAHARA Katsuhiro, TAJIMA Takuya, YAMAGUCHI Nami, SAKIHAMA Tomomi, NAGASAWA Makoto, KAWANO Keisuke

60 ( 3 ) 373 - 377 2011.9

Language：Japanese Publishing type：Research paper (scientific journal)

透析中の関節リウマチ患者に対するミゾリビンの使用経験 Reviewed

税所幸一郎，坂田勝美，小牧ゆか，濱田浩朗，帖佐悦男

九州リウマチ 31 ( 2 ) 98 - 103 2011.9

Language：Japanese Publishing type：Research paper (scientific journal)

膝関節捻挫 Invited Reviewed

帖佐悦男

医学と薬学 66 ( 3 ) 423 - 428 2011.9

Language：Japanese Publishing type：Research paper (scientific journal)

スポーツと腰痛　疫学調査から Invited Reviewed

帖佐悦男

脊椎脊髄ジャーナル 24 ( 9 ) 840 - 845 2011.9

Language：Japanese Publishing type：Research paper (scientific journal)

Follow-up of the Conservative Treatment for the Rotator Cuff Tear Reviewed

35 ( 2 ) 535 - 537 2011.8

Language：Japanese Publishing type：Research paper (scientific journal)

TKA手術手技の習得と指導

柏木輝行，矢野良英，花堂祥治，小島岳史，帖佐悦男

宮崎整形外科懇話会論文集 ( 15 ) 3 - 4 2011.7

Language：Japanese Publishing type：Research paper (other academic)

当科における鏡視下腱板修復術（ＡＲＣＲ）の成績

石田康行、矢野浩明、山本惠太郎、河原勝博、田島卓也、山口奈美、﨑濵智美、長澤誠、宮元修子、帖佐悦男

宮崎整形外科懇話会論文集 ( 15 ) 83 - 84 2011.7

Language：Japanese Publishing type：Research paper (international conference proceedings)

膝蓋腱断裂に対し、Ｅｃｋｅｒ法にて治療した1例

小島岳史、花堂祥治、矢野良英、柏木輝行、塩﨑猛、田島卓也、帖佐悦男

宮崎整形外科懇話会論文集 ( 15 ) 61 - 63 2011.7

Language：Japanese Publishing type：Research paper (international conference proceedings)

K-015 宮崎県におけるスポーツ外傷・障害に対する取り組み : スポーツ人材育成システムの紹介を含め(スポーツ理学療法としての地域貢献〜スポーツランドみやざき構想・スポーツメディカルサポートシステムの紹介〜,大会特別企画公開講演スポーツリハ編,第46回日本理学療法学術大会)

帖佐悦男

理学療法学 38 ( 1 ) 2011.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：公益社団法人日本理学療法士協会

Clinical outcome and the postoperative MRI findings of arthroscopic rotator cuff repair

ISHIDA Yasuyuki, YAMAMOTO Keitaro, TAJIMA Takuya, YAMAGUCHI Nami, SAKIHAMA Tomomi, CHOSA Etsuo

JOSKAS 36 ( 2 ) 212 - 216 2011.5

Language：Japanese Publishing type：Research paper (scientific journal)

Bone apposition of the acetabular rim in deep hips: A distinct finding of global pincer impingement

Corten K., Ganz R., Chosa E., Leunig M.

Journal of Bone and Joint Surgery - Series A 93 ( SUPPL. 2 ) 10 - 16 2011.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Bone and Joint Surgery - Series A

Background: Hips with coxa profunda can develop a pincer-type impingement with linear impact between the proximal part of the femur and the acetabulum, leading to bone apposition on the acetabular rim. Methods: Twenty hips with radiographic features of rim ossification were isolated from a pilot cohort of 220 patients for histologic assessment of the acetabular rim and the labrum. In the second part of the study, the prevalence of radiographic signs of bone apposition in a cohort of 148 hips treated for femoroacetabular impingement was assessed. Results: Histologic analysis confirmed that the labrum may become displaced and replaced by the appositional bone formation. The double-line sign and the recess sign are suggestive of an ongoing process of this bone formation, and the described phenotypes of bone apposition indicate the site of the impingement problem. Morphological anomalies of the proximal part of the femur, such as a low neck-shaft angle or a short femoral neck, may further contribute to the mechanism of pincer impingement. Conclusions: In later stages, this bone formation cannot be distinguished from the native bone and the labrum may appear to be nearly absent on imaging studies. While the bone apposition on the rim is first reactive to chronic impingement, the impingement then increases and may lead to further bone apposition. Copyright © 2011 by the Journal of Bone and Joint Surgery, Incorporated.

DOI： 10.2106/JBJS.J.01799

Gait Analysis of Patients with Clubfoot following Posteromedial Release Procedure

当科における鏡視下腱板修復術の成績　術後1年のMRI像と臨床成績 Reviewed

石田康行, 山本惠太郎, 田島卓也, 山口奈美, 崎濱智美, 帖佐悦男

JOSKAS 36 ( 2 ) 212 - 216 2011.5

Language：Japanese Publishing type：Research paper (scientific journal)

膝前十字靭帯再再建術症例の検討 Reviewed

田島卓也，山本惠太郎，石田康行，山口奈美，崎濵智美，帖佐悦男

JOSKAS 36 258 - 268 2011.5

Language：Japanese Publishing type：Research paper (scientific journal)

学校における運動器検診の実施について Invited Reviewed

山本惠太郎、帖佐悦男、山口奈美、福嶋麻里、稲倉正孝、佐藤雄一、高村一志、中村典生、岡田光司、田島直也、平川俊一

宮崎県医師会医学会誌 35 ( 1 ) 49 - 54 2011.3

Language：Japanese Publishing type：Research paper (scientific journal)

見過ごしやすい整形外科疾患～骨折の画像診断を中心に～ Invited Reviewed

矢野浩明、帖佐悦男

宮崎県医師会医学会誌 35 ( 1 ) 55 - 60 2011.3

Language：Japanese Publishing type：Research paper (scientific journal)

KADOUCHI Ichiro, YANAGIZONO Taiichiro, KAWANO Akihiro, KATSUSHIMA Yoko, WATANABE Shinji, CHOSA Etsuo

60 ( 1 ) 135 - 138 2011.3

Language：Japanese Publishing type：Research paper (scientific journal)

外偏平足に対する踵骨延長術前後の歩行分析評価 Reviewed

勝嶌葉子、門内一郎、川野彰裕、渡邊信二、柳園賜一郎、帖佐悦男

整形外科と災害外科 60 ( 1 ) 130 - 134 2011.3

Language：Japanese Publishing type：Research paper (scientific journal)

単純Xせんによる股関節疾患の画像診断 Invited Reviewed

帖佐悦男

Orthopaedicｓ 24 ( 2 ) 1 - 7 2011.2

Language：Japanese Publishing type：Research paper (scientific journal)

変形性膝関節症に対する運動療法・体操　-ロコモ予防への取組 Invited Reviewed

帖佐悦男、宮崎茂明、渡辺将成

週刊　医学のあゆみ 236 ( 5 ) 383 - 387 2011.1

Language：Japanese Publishing type：Research paper (scientific journal)

スポーツと腰痛-疫学的調査- Reviewed

帖佐悦男

第２１回腰痛シンポジウム　スポーツと腰痛-最新の知見-　講演記録集 5 - 13 2011.1

Language：Japanese Publishing type：Research paper (scientific journal)

橈骨頭亜脱臼を伴う上腕骨小頭部離断性骨軟部骨炎の2症例 Reviewed

石田康行、帖佐悦男、矢野浩明、山口奈美、﨑濵智美、

日本肘関節学会雑誌 17 ( 2 ) 97 - 104 2011.1

Language：Japanese Publishing type：Research paper (scientific journal)

Comparison of Clinical Results of 120.DEG. and 125.DEG. Gamma 3 Nail for Trochanteric Fracture

Kojima Takeshi, Kashiwagi Teruyuki, Hanado Shoji, Yano Yoshihide, Chosa Etsuo

Orthopedics & Traumatology 60 ( 3 ) 502 - 508 2011

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

We compared the clinical results of trochanteric fractures treated with Gamma 3 nails with CCD angles of 120° and 125°. Twenty cases that were treated by a single surgeon from January 2010 to August 2010. They consisted of three males and 17 females with average age or 83.3 years old. Their medical reports were reviewed for number of days to operation, operating time, Tip-Apex Distance (TAD), position of lag screw and the amount slid by the lag screw (after 1 week or after 2 weeks). As a result, there was no significant difference in the four parameters. Regarding the lag screw position in the femoral head, in eight cases treated with 120° Gamma 3 nails, the lag screw was positioned at the center or inferiorly in the AP view; and in two cases treated with 120° Gamma 3 nails, the lag screw was positioned posteriorly in the ML view. With Gamma 3 nail of 125° CCD angle, in eight cases the lag screw was positioned at the center or inferiorly in the AP view, and in two cases, the lag screw was positioned posteriorly in the ML view. Gamma 3 nails of 120° CCD angle enables the lag screw to be placed more easily into the inferior part of the femoral head than the 125° CCD angle, and they do not have any negative impact on lag screw sliding. These results suggest that Gamma 3 nails with 120° CCD angle can sene as an efficient method for treating trochanteric fractures.

DOI： 10.5035/nishiseisai.60.502

Gait Analysis in Patient with Pes Planovalgus Deformity of the Hindfoot after Calcaneal Lengthening

Katsushima Yoko, Kadouchi Ichiro, Kawano Akihiro, Watanabe Shinji, Yanagizono Taiichiro, Chosa Etsuo

Orthopedics & Traumatology 60 ( 1 ) 130 - 134 2011

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

Pes planovalgus is a common deformity in children and calcaneal lengthning osteotomy is an useful operation. We performed the operation on a 9-year-old female patient with bilateral planovalgus feet and evaluated her pre and post operative states. Three- dimensional gait data was collected with the ANIMA motion analysis system (MA2000). Four force plates (MG-1090) were used for kinematic analysis. The data of the patient was compared to our data for normal adults before operation and at six months after surgery. The kinetic and kinematic parameter had normalized after treatment. Improvement of feet alignment caused hyperextension of her knees. We have to observe the course of her knees carefully hereafter.

DOI： 10.5035/nishiseisai.60.130

投球動作における3次元動作解析と肩甲帯周囲の筋活動特性:wavelet変換による動的周波数解析

宮崎茂明, 石田康行, 渡辺将成, 平安堅吾, 常盤直孝, 加藤浩, 帖佐悦男, 鳥取部光司, 河原勝博

日本理学療法学術大会 2010 ( 0 ) CcOF2064 - CcOF2064 2011

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：JAPANESE PHYSICAL THERAPY ASSOCIATION

【目的】 近年，投球障害肩の原因についての様々な研究，報告がなされており，一定の成果を挙げている．しかし，従来の筋力評価は腱板の筋活動に関する報告が多く，肩甲帯周囲の筋活動に関しての報告は少ない．また，wavelet変換（以下，WT）を用いた表面筋電図（以下，EMG）周波数解析により投球動作時の筋活動を報告したものはない．本研究の目的は，投球動作時の肩関節，胸椎，骨盤の各角度と身体重心移動距離を3次元動作解析装置にて測定し，WTを用いたEMG周波数解析による肩甲帯周囲筋の動的EMG周波数特性との関連性について検討することである． 【方法】 対象は硬式高校野球選手の投手8名とした．対象の条件として，測定前1ヶ月以内に投球動作による肩関節痛が生じた経験があり，かつ測定時には肩関節痛が生じなかった選手とした．疼痛発生部位は肩関節前方部，疼痛発生位相はacceleration期であった．この8名を対象群とした．コントロール群として，投球時に肩関節痛のない硬式高校野球選手の投手10名とした．投球動作解析は3次元動作分析装置Vicon Nexus（Vicon Motion Systems社製）と赤外線カメラMX-3（Vicon Motion Systems社製）7台を用いた．サンプリング周波数は100Hzとした．筋活動の測定には表面筋電計テレマイオ2400T（Noraxon社製）を用い，サンプリング周波数は1.5kHzとした．検討項目は，3次元動作解析は肩関節（外転，水平伸展，外旋）角度，胸椎（屈曲，伸展）角度，骨盤（前傾，後傾）角度と身体重心移動距離とした．EMG解析は僧帽筋上部線維，僧帽筋中部線維，僧帽筋下部線維，前鋸筋，三角筋後部線維について連続WTを用いた時間周波数解析を行った．投球動作各位相時の平均周波数を算出し，各位相間での平均周波数の最小値と最大値を求め，その差分（以下，MPFR）を算出した．また，得られたEMG周波数パワースペクトルを12.5～60Hz，61～120Hz，121～200Hzの3つの帯域に分類し，各周波数パワースペクトル帯域の累積パワー（平均値）を算出した．統計処理はMann-Whitney's U testを行い，有意水準は5％未満とした． 【説明と同意】 研究の内容については宮崎大学医学部倫理委員会の承認を得た．対象者には研究の目的と内容を説明し，文書にて同意を得て行った． 【結果】 対象群はコントロール群と比し，肩関節外旋角度はacceleration期のボールリリース時において有意に低値を示した．肩関節最大外旋角度（以下，MER）は有意差を認めなかった．胸椎伸展角度はacceleration期，骨盤前傾角度はcocking期，acceleration期においてそれぞれ有意に低値を示した．身体重心移動距離はcocking期において前方移動距離，acceleration期においてステップ脚方向移動距離で有意に低値を示した．MPFRはcocking期の僧帽筋上部線維において有意に高値を示し, acceleration期の僧帽筋下部線維において有意に低値を示した．累積パワーは各位相において有意差を認めなかった． 【考察】 MERに関わる要因として，肩関節外旋運動は肩甲上腕関節外旋運動，肩甲骨後傾運動，胸椎伸展運動などの連動により遂行される．今回，対象群はコントロール群と比し，MERは有意差を認めず，胸椎伸展角度，骨盤前傾角度，身体重心移動距離において有意に低値を示した．このことから肩甲上腕関節外旋角度が増加していると推測され，負荷が増大したと考えられた．また，ボールリリース時の肩関節外旋角度が低下していることから，重心後方荷重傾向により体幹回旋からの連動が減少し，肩関節水平内転運動で肩関節外旋運動を誘導したと考えられた．肩甲帯周囲の筋活動特性について，対象群はコントロール群と比し，MPFRがcocking期の僧帽筋上部線維において有意に高値を示し, acceleration期の僧帽筋下部線維において有意に低値を示した．このことから，胸椎伸展角度，骨盤前傾角度の低下による僧帽筋上部線維，下部線維のインバランスの影響が考えられ，僧帽筋下部線維において積極的なtype2筋線維の筋活動が引き起こされず， cocking期からacceleration期の肩関節外転時に必要な肩甲骨内転，上方回旋，後傾作用が低下したと推察された．これにより，代償的に僧帽筋上部線維におけるtype2筋線維の筋活動が優位になり，cocking期において肩甲骨挙上作用が増加したと推察された． 【理学療法学研究としての意義】 投球障害肩の予防，改善には，投球動作の改善と身体機能の向上が必要とされる．本研究の結果より，投球障害肩のリハビリテーションでは，肩甲骨を含めた胸郭，上部体幹の柔軟性と肩甲帯周囲の筋活動バランスの改善が必要であると考えられた．なお本研究は，平成21年度宮崎県理学療法士会研究助成事業の採択を受けて実施したものである．

DOI： 10.14900/cjpt.2010.0.CcOF2064.0

橈骨頭亜脱臼を伴う上腕骨小頭部離断性骨軟骨炎の2症例 Reviewed

石田康行, 帖佐悦男, 矢野浩明, 山口奈美, 崎濱智美

日本肘関節学会雑誌 17 ( 2 ) 97 - 100 2010.12

Language：Japanese Publishing type：Research paper (scientific journal)

骨盤・股関節・大腿部のスポーツ傷害とメディカルチェックのポイント Invited

帖佐悦男

整形・災害外科 53 ( 13 ) 1593 - 1599 2010.12

Language：Japanese Publishing type：Research paper (scientific journal)

外側型腰椎椎間板ヘルニアの術後成績 Reviewed

濱中秀昭、久保紳一郎、黒木浩史、猪俣尚規、福嶋秀一郎、黒木修司、比嘉聖、長澤誠、帖佐悦男

Journal of Spine Research 1 ( 12 ) 2144 - 2147 2010.12

Language：Japanese Publishing type：Research paper (scientific journal)

競技スポーツ帯同時に役立つ外傷初期治療ガイド　頻発するスポーツ外傷に対する処置・治療の実際「ラグビー」 Invited Reviewed

田島卓也、帖佐悦男

臨床スポーツ医学 27 ( 臨時増刊号 ) 277 - 282 2010.12

Language：Japanese Publishing type：Research paper (scientific journal)

橈骨頭亜脱臼を伴う上腕骨小頭部離断性骨軟骨炎の2症例 Reviewed

石田康行，帖佐悦男，矢野浩明，山口奈美，崎濱智美

日本肘関節学会雑誌 17 ( 2 ) 97 - 100 2010.12

Language：Japanese Publishing type：Research paper (scientific journal)

突発性側弯症に対する装具矯正能の評価　ぶら下がり全脊椎単純Ｘ線撮影の応用 Reviewed

黒木浩史、猪俣尚規、久保紳一郎、帖佐悦男、田島直也

Journal of Spine Research 1 ( 11 ) 1955 - 1959 2010.11

Language：Japanese Publishing type：Research paper (scientific journal)

Posterior Occipito-axial Fixation with C2 Laminar Screws for Pediatric Atlanto-axial Instability in Down Syndrome : Two Cases Report

KUROKI Hiroshi, KUBO Shinichiro, HAMANAKA Hideaki, INOMATA Naoki, HANADO Shoji, CHOSA Etsuo

Journal of spine research 1 ( 10 ) 1780 - 1785 2010.10

Language：Japanese Publishing type：Research paper (scientific journal)

股関節の手術的脱臼法 Invited Reviewed

帖佐悦男

整形・災害外科 53 ( 11 ) 1306 - 1307 2010.10

Language：Japanese Publishing type：Research paper (scientific journal)

反張膝に対する歩行分析-正常および前十字靭帯損傷膝の検討- Reviewed

河原勝博、帖佐悦男、鳥取部光司、渡邊信二

臨床バイオメカニクス 31 415 - 420 2010.10

Language：Japanese Publishing type：Research paper (scientific journal)

肩関節過外転で生じたbony PASTA lesion の1例 Reviewed

石田康行、帖佐悦男、矢野浩明、山本惠太郎、河原勝博、田島卓也、山口奈美、﨑濵智美

日本関節鏡・膝・スポーツ整形外科学会雑誌 35 468 - 471 2010.10

Language：Japanese Publishing type：Research paper (scientific journal)

棘窩切痕部ガングリオンに対する肩峰下滑液包からの鏡視下除圧術の短期成績 Reviewed

石田康行、帖佐悦男、矢野浩明、山本惠太郎、河原勝博、田島卓也、山口奈美、﨑濵智美

日本関節鏡・膝・スポーツ整形外科学会雑誌 35 338 - 341 2010.10

Language：Japanese Publishing type：Research paper (scientific journal)

臼蓋形成不全に対する寛骨臼骨切り術における回転角度の力学的検討 Reviewed

趙昕、帖佐悦男、鳥取部光司、渡邊信二、河原勝博、鄧鋼

臨床バイオメカニクス 31 137 - 141 2010.10

Language：Japanese Publishing type：Research paper (scientific journal)

ダウン症候群に起因した環軸椎不安定症小児例に対する後頭軸椎後方固定術の経験　laminar screw法の応用 Reviewed

黒木浩史、久保紳一郎、濱中秀昭、猪俣尚規、花堂祥治、帖佐悦男

Journal of Spine Research 1 ( 10 ) 1780 - 1785 2010.10

Language：Japanese Publishing type：Research paper (scientific journal)

人工関節置換術におけるロングステム固定性の有限要素解析 Reviewed

鳥取部光司、帖佐悦男、趙昕、渡邊信二、河原勝博、鄧鋼

臨床バイオメカニクス 31 289 - 292 2010.10

Language：Japanese Publishing type：Research paper (scientific journal)

ダウン症候群に起因した環軸椎不安定症小児例に対する後頭軸椎後方固定術の経験 Reviewed

黒木浩史，久保紳一郎，濱中秀昭，猪俣尚規，花堂祥治，帖佐悦男

Journal of Spine Research 1 ( 10 ) 1780 - 1785 2010.10

Language：Japanese Publishing type：Research paper (scientific journal)

ダウン症候群に起因した環軸椎不安定症小児例に対する後頭軸椎後方固定術の経験 Reviewed

黒木浩史、久保紳一郎、濱中秀昭、猪俣尚規、花堂祥治、帖佐悦男

Journal of Spine Research 1 ( 10 ) 1780 - 1785 2010.10

Language：Japanese Publishing type：Research paper (scientific journal)

関節リウマチの合併症 Invited Reviewed

帖佐悦男

はまゆう(社団）日本リウマチ友の会宮崎支部 ( 36 ) 8 - 12 2010.9

Language：Japanese Publishing type：Research paper (scientific journal)

A Case Report of Endoscopic Iliotibial Band Release for Contracture of Tensor Fasciae Latae Muscle-Iliotibial Band

NAGASAWA Makoto, CHOSA Etsuo, SAKAMOTO Takero, WATANABE Shinji, SEKIMOTO Tomohisa, HAMADA Hiroo, NOZAKI Shotaro, IKEJIRI Hiroshi, NAKAMURA Yoshihiro, FUKUDA Hajime, HIYOSHI Masaru

Orthopedics & Traumatology 59 ( 4 ) 788 - 791 2010.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

We report a case of endoscopic iliotibial band release for contracture of the tensor fasciae latae muscle-iliotibial band. A 20-year-old female consulted our hospital complaining of abduction and flexion contracture of the hip joint. We could not confirm any history of intramuscular injection in her childhood. We performed operation after she resisted conservative therapy. Endoscopic iliotibial band release for the contracture of the tensor fasciae latae muscle-iliotibial band improved excursion and claudication. Use of the endscope is generally good for intra-articular treatments. In this case it was useful for the treatment of hypodermic tissue. This operation confirms contracture under movement and minimally invasive surgery.

DOI： 10.5035/nishiseisai.59.788

Finite element analysis of the long femoral stem fixation in hip arthroplasty

TOTORIBE Koji, CHOSA Etsuo, ZHAO Xin, WATANABE Shinji, KAWAHARA Katsuhiro, DENG Gang

Japanese journal of clinical biomechanics 31 289 - 292 2010.9

Language：Japanese Publishing type：Research paper (scientific journal)

Gait analysis of back knee : Examination of sound knee and anterior cruciate ligament deficient knee

KAWAHARA Katsuhiro, CHOSA Etsuo, TOTORIBE Koji, WATANABE Shinji

Japanese journal of clinical biomechanics 31 415 - 420 2010.9

Language：Japanese Publishing type：Research paper (scientific journal)

当科における超高年齢者の頚椎手術の術後成績 Reviewed

黒木修司、久保紳一郎、黒木浩史、花堂祥治、濱中秀昭、猪俣尚規、福嶋秀一郎、比嘉聖、長澤誠、帖佐悦男

整形外科と災害外科 59 ( 4 ) 757 - 760 2010.9

Language：Japanese Publishing type：Research paper (scientific journal)

脊椎手術を施行した透析患者症例の検討 Reviewed

濱中秀昭、久保紳一郎、黒木浩史、猪俣尚規、福嶋秀一郎、黒木修司、比嘉聖、長澤誠、帖佐悦男

整形外科と災害外科 59 ( 4 ) 432 - 436 2010.9

Language：Japanese Publishing type：Research paper (scientific journal)

変形性肘関節症に対する鏡視下手術の治療経験 Reviewed

﨑濵智美、石田康行、矢野浩明、山本惠太郎、河原勝博、田島卓也、山口奈美、深尾悠、河野雅充、帖佐悦男

整形外科と災害外科 59 ( 4 ) 533 - 535 2010.9

Language：Japanese Publishing type：Research paper (scientific journal)

大腿筋膜張筋-腸脛靭帯拘縮に対し内視鏡を用いた腸脛靭帯節理術を施行した一例 Reviewed

長澤誠、帖佐悦男、坂本武郎、渡邊信二、関本朝久、濱田浩朗、野﨑正太郎、池尻洋史、中村嘉宏、福田一、日吉優

整形外科と災害外科 59 ( 4 ) 788 - 791 2010.9

Language：Japanese Publishing type：Research paper (scientific journal)

スポーツと腰痛　 Invited Reviewed

帖佐悦男

CLINICIAN　運動器の10年 57 ( 9 ) 974 - 975 2010.9

Language：Japanese Publishing type：Research paper (other academic)

Effect of periacetabular osteotomy for acetabular dysplasia clarified　by three-dimensional finite element analysis Reviewed

XIN ZHAO1, ETSUO CHOSA1, KOJI TOTORIBE1, and GANG DENG

Journal of Orthopaedic science 15 632 - 640 2010.9

Language：English Publishing type：Research paper (scientific journal)

宮崎県高校女子バスケットボール国体候補選手10名に対するメディカルチェック-3年間の調査結果と問題点- Reviewed

山口奈美、山本惠太郎、石田康行、河原勝博、田島卓也、帖佐悦男、田島直也

日整会スポーツ医学会雑誌 30 ( 2 ) 79 - 86 2010.9

Language：Japanese Publishing type：Research paper (scientific journal)

肩下筋負荷テストと鏡視所見の検討 Reviewed

石田康行、帖佐悦男、矢野浩明、﨑濵智美

肩関節 34 ( 3 ) 609 - 611 2010.8

Language：Japanese Publishing type：Research paper (scientific journal)

肩甲下筋負荷テストと鏡視所見の検討 Reviewed

石田康行、帖佐悦男、矢野浩明、﨑濵智美

肩関節　別冊 34 ( 3 ) 609 - 611 2010.8

Language：Japanese Publishing type：Research paper (scientific journal)

Locomotive Syndromeを予防するためのスポーツ医・科学的アプローチ　-サポートシステムの構築- Invited Reviewed

帖佐悦男

日整会スポーツ医学会雑誌 30 ( 3 ) 151 - 155 2010.8

Language：Japanese Publishing type：Research paper (scientific journal)

Plasma adrenomedullin and proadrenomedullin N-terminal 20 peptide in patients diagnosed as having early rheumatoid arthritis.

Hamada H., Saisyo K., Sekimoto T., Chosa E.

Modern rheumatology / the Japan Rheumatism Association 20 ( 4 ) 389 - 395 2010.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Modern rheumatology / the Japan Rheumatism Association

The aim of this study was to investigate plasma adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) level in patients diagnosed with early rheumatoid arthritis (RA). Furthermore, several inflammatory cytokines were measured in those patients to clarify the roles of AM and PAMP. Forty patients diagnosed with early RA (women 46 +/- 8.5 years old) and 10 healthy controls (women 57 +/- 5 years old) were studied. Plasma levels of AM, PAMP, matrix metalloprotease 3 (MMP-3), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and C-reactive protein (CRP) were measured using an immunoradiometric assay and enzyme-linked immunosorbent asay (ELISA) methods. The plasma levels of AM (17.5 +/- 8.4 fmol/ml) and PAMP (2.01 +/- 0.57 fmol/ml) in patients exceeded those in healthy controls (AM 8.6 +/- 1.7, PAMP 1.17 +/- 0.34 fmol/ml). Moreover, plasma AM and PAMP levels demonstrated a significantly positive correlation with plasma MMP-3 and IL-6 levels. Nevertheless, CRP and TNF-alpha levels in these patients showed no significant correlation with plasma AM and PAMP levels. These data support the possible role for AM and PAMP in the pathophysiology of early RA.

DOI： 10.1007/s10165-010-0295-5

Sports Medical and Scientific Approaches to Prevent "the Locomotive Syndrome"

CHOSA Etsuo

30 ( 3 ) 151 - 155 2010.7

Language：Japanese Publishing type：Research paper (scientific journal)

地域におけるロコモティブシンドローム Invited Reviewed

帖佐悦男

治療学 44 ( 7 ) 71 - 74 2010.7

Language：Japanese Publishing type：Research paper (scientific journal)

肩関節過外転で生じたbony PASTA lesion の1例 Invited Reviewed

石田康行、帖佐悦男、矢野浩明、山本惠太郎、河原勝博、山口奈美、﨑濵智美

日本関節鏡・膝・スポーツ整形外科学会雑誌 35 468 - 471 2010.5

Language：Japanese Publishing type：Research paper (scientific journal)

Medical Check for 10 Female High-school Basketball Players in Miyazaki who Take Part of the Japan National Sports Festival : Results and Problems for Three Years

YAMAGUCHI Nami, YAMAMOTO Keitaro, ISHIDA Yasuyuki, KAWAHARA Katsuhiro, TAJIMA Takuya, CHOSA Etsuo, TAJIMA Naoya

30 ( 2 ) 79 - 86 2010.5

Language：Japanese Publishing type：Research paper (scientific journal)

「運動器の10年」事業報告　学校における運動器検診の実施について Reviewed

山本惠太郎、山口奈美、福嶋麻里、山口志保子、帖佐悦男、田島直也、岡田光司

宮崎整形外科懇話会論文集 ( 14 ) 93 - 97 2010.5

Language：Japanese Publishing type：Research paper (scientific journal)

前十字靭帯付着部裂離骨折の３症例 Reviewed

山口奈美、矢野浩明、山本惠太郎、石田康行、河原勝博、田島卓也、﨑濵智美、深尾悠、山口志保子、帖佐悦男

宮崎整形外科懇話会論文集 ( 14 ) 79 - 81 2010.5

Language：Japanese Publishing type：Research paper (scientific journal)

Damage Control Orthopaedicsの概念に基づいた多発外傷患者への治療戦略 Reviewed

中村嘉宏、帖佐悦男、野﨑正太郎

宮崎整形外科懇話会論文集 ( 14 ) 65 - 65 2010.5

Language：Japanese Publishing type：Research paper (scientific journal)

棘上筋腱大結節付着部関節面側裂離骨折後の肩インピンジメント症候群に対する鏡視下手術の経験 Reviewed

石田康行、帖佐悦男、矢野浩明、山本惠太郎、河原勝博、田島卓也、﨑濵智美、日吉優

宮崎整形外科懇話会論文集 ( 14 ) 19 - 21 2010.5

Language：Japanese Publishing type：Research paper (scientific journal)

Sacral insufficiency fracture の治療経験 Reviewed

猪俣尚規、久保紳一郎、黒木浩史、濱中秀昭、花堂祥治、海田博志、梅崎哲也、深尾悠、帖佐悦男

宮崎整形外科懇話会論文集 ( 14 ) 13 - 15 2010.5

Language：Japanese Publishing type：Research paper (scientific journal)

Modified Stoppa Approachが有用と思われた臼蓋底骨折の２症例 Reviewed

野﨑正太郎、帖佐悦男、坂本武郎、関本朝久、渡邊信二、濱田浩朗、前田和徳、池尻洋史、中村嘉宏、福田一、山口志保子、河野雅充、酒井健

宮崎整形外科懇話会論文集 ( 14 ) 11 - 11 2010.5

Language：Japanese Publishing type：Research paper (scientific journal)

股関節疾患 Invited Reviewed

帖佐悦男

関節外科 29 ( 4月増刊 ) 88 - 98 2010.4

Language：Japanese Publishing type：Research paper (scientific journal)

Plasma adrenomedullin and proadrenomedullin N-terminal20 peptide in patients diagnosed as having early rheumatoid　arthritis Reviewed

Hiroaki Hamada,Koihiro Saisyo,Tomohisa Sekimoto, Etsuo Chosa

Mod Rheumatol 20 ( 4 ) 389 - 395 2010.4

Language：English Publishing type：Research paper (scientific journal)

腸恥滑液包炎により大腿神経障害を生じた関節リウマチの一例 Reviewed

税所幸一郎、坂田勝美、吉川大輔、帖佐悦男、久保紳一郎、濱田浩朗

日本関節病学会誌 29 ( 1 ) 95 - 100 2010.3

Language：Japanese Publishing type：Research paper (scientific journal)

Study of the Approach to Treatment of Combined Ligament Injury Involving Posterior Cruciate Ligament of the Knee

FUKAO Yu, YAMAMOTO Keitaro, YANO Hiroaki, KAWAHARA Katsuhiro, ISHIDA Yasuyuki, TAJIMA Takuya, YAMAGUCHI Nami, SAKIHAMA Tomomi, YAMAGUCHI Shihoko, CHOSA Etsuo

59 ( 1 ) 178 - 182 2010.3

Language：Japanese Publishing type：Research paper (scientific journal)

膝複合靭帯損傷例における後十字靭帯治療法の検討（共著） Reviewed

深尾悠, 山本惠太郎, 矢野浩明, 河原勝博, 石田康行, 田島卓也, 山口奈美, 﨑濵智美, 山口志保子, 帖佐悦男

整形外科と災害外科 59 ( 1 ) 178 - 182 2010.3

Language：Japanese Publishing type：Research paper (scientific journal)

環椎外側塊スクリュー法の安全性評価（共著） Reviewed

久保紳一郎, 黒木浩史, 花堂祥治, 濱中秀昭, 猪俣尚規, 黒木修司, 帖佐悦男

整形外科と災害外科 59 ( 1 ) 14 - 17 2010.3

Language：Japanese Publishing type：Research paper (scientific journal)

Evaluation of Surgical Site Infection in Spinal Surgery. "jointly worked" Reviewed

59 ( 1 ) 1 - 7 2010.3

Language：Japanese Publishing type：Research paper (scientific journal)

Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis Reviewed

Shin-ichiro Hino,Shinichi Kondo,Kazuya Yoshinaga,Atsushi Saito,Tomohiko Murakami, Soshi Kanemoto, Hiroshi Sekiya, Kazuyasu Chihara,Yuji Aikawa,Hideaki Hara,Takashi Kudo,Tomohisa Sekimoto,Taro Funamoto, Etsuo Chosa,Kazunori Imaizumi

J Bone Miner Metab 28 131 - 138 2010.3

Language：English Publishing type：Research paper (scientific journal)

宮崎県少年選手におけるメディカルチェック-障害・外傷と関節弛緩性・筋柔軟性との関連について- Reviewed

河原勝博、帖佐悦男、山本惠太郎、田島卓也、園田典夫、田島直也

日本臨床スポーツ医学会誌 18 ( 1 ) 59 - 66 2010.1

Language：Japanese Publishing type：Research paper (scientific journal)

Relationship between athletic disability, injury and joint laxity, muscle tightness for young athletes of medical check-up in Miyazaki

KAWAHARA K., CHOSA E., YAMAMOTO K., TAJIMA T., SONODA N., TAJIMA N.

Japanese journal of clinical sports medicine 18 ( 1 ) 59 - 66 2010.1

Language：Japanese Publishing type：Research paper (scientific journal)

宮崎県少年選手におけるメディカルチェック-障害・外傷と関節弛緩性・筋柔軟性との関連について-（共著） Reviewed

河原勝博, 帖佐悦男, 山本惠太郎, 田島卓也, 園田典夫, 田島直也

日本臨床スポーツ医学会誌 18 ( 1 ) 59 - 66 2010.1

Language：Japanese Publishing type：Research paper (scientific journal)

Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cells

Yoshikawa N., Yoshikawa N., Nemoto T., Satoh S., Maruta T., Yanagita T., Chosa E., Wada A.

Neurochemistry International 56 ( 1 ) 42 - 50 2010.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neurochemistry International

Multiple signaling pathways via insulin receptor substrate-1 and -2 play crucial roles in health, diseases, and therapeutics (i.e., longevity, tumorigenesis, and neuroprotection). The 90-kDa heat-shock protein (Hsp90) is an emerging target molecule of therapeutics, Hsp90 inhibitors being promising against various diseases (e.g., cancer, brain and cardiac ischemia, and neurodegenerative diseases). Much remains, however, unknown whether Hsp90 could regulate insulin receptor substrate-1 and -2 signaling pathways. In cultured bovine adrenal chromaffin cells, we observed that 24-h treatment with 1 μM geldanamycin (an inhibitor of Hsp90) decreased insulin receptor substrate-1 level, while increasing insulin receptor substrate-2 level; besides, geldanamycin lowered phosphoinositide 3-kinase, phosphoinositide-dependent kinase-1, Akt, glycogen synthase kinase-3β, and Raf-1 levels, without changing extracellular signal-regulated kinase and its upstream kinase levels. Chronic (≥12 h) treatment with 0.1-10 μM Hsp90 inhibitor (geldanamycin, 17-allylamino-17-demethoxy-geldanamycin, herbimycin A, and radicicol) decreased insulin receptor substrate-1 level by ∼66%, while increasing insulin receptor substrate-2 level by ∼160%. These effects of geldanamycin (IC 50 155 nM, EC 50 177 nM) and 17-allylamino-17-demethoxy-geldanamycin (IC 50 310 nM, EC 50 260 nM) were time- and concentration-dependent. Geldanamycin-induced decrease of insulin receptor substrate-1 was attenuated by lactacystin, β-lactone or MG132 (proteasome inhibitor), but not by calpastatin (calpain inhibitor) or leupeptin (lysosome inhibitor); geldanamycin did not affect heteroprotein complex formation between insulin receptor substrate-1 or -2 and Hsp90. Geldanamycin-induced increase of insulin receptor substrate-2 was prevented by cycloheximide or actinomycin D. Geldanamycin lowered insulin receptor substrate-1 mRNA level by ∼39%, while raising insulin receptor substrate-2 mRNA level by ∼109% between 3 and 24 h, without changing the stability of insulin receptor substrate-1 and -2 mRNAs. Nuclear run-on assay revealed that geldanamycin retarded insulin receptor substrate-1 gene transcription by 42%, while accelerating insulin receptor substrate-2 gene transcription by 41%. Hsp90 inhibitors oppositely altered insulin receptor substrate-1 and -2 levels via proteasomal degradation and gene transcription. © 2009 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.neuint.2009.08.013

宮崎県におけるスポーツ活動サポートのための人材育成への取り組み（第1報）

井﨑守, 大山史朗, 房野絹可, 児玉祐二, 尾﨑勝博, 常盤直孝, 椋田俊博, 宮崎茂明, 田島直也, 帖佐悦男

日本理学療法学術大会 2009 ( 0 ) C4P1123 - C4P1123 2010

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：JAPANESE PHYSICAL THERAPY ASSOCIATION

【目的】 宮崎県理学療法士会（以下、宮崎県士会）では、スポーツ健康増進部を中心に、スポーツ現場でのサポート活動を行なってきた。しかし、「サポート活動に関わる人材不足」「人材の局在化によりネットワークが構築できない」「活動に携わるための環境不備」などの問題点があり、その解決が課題であった。これらに対し、平成20年11月「みやざきトレーナーズセミナー（以下、MTS）」を設立し、隔月開催で2年間、計13回の育成プログラムを開始している。今回、活動から1年を迎えるにあたり、MTSの課題と展望について検証を行なった。 【方法】 MTS会員を対象に、サポート活動に関するアンケート調査を開始時（以下、初回調査）と平成21年9月開催時（以下、中間調査）に実施した。調査項目は所属地域、理学療法士経験年数、活動の有無・年数・形態・意欲・展望とし、回答は選択方式とした。一部の調査項目については回答率の変化を、χ2検定にてクロス集計表を用い検討し、有意水準は5％未満とした。 【説明と同意】 回答は無記名とし、調査結果を今後の検証に役立てることを説明した上で実施した。 【結果】 1.MTS登録会員は99名で、アンケート回収率は初回調査が65％、中間調査が98％であった。 2.MTS会員は宮崎県市郡部の広域から構成されていた。 3.サポート活動を行っている会員の割合は「初回調査18％（n=62）、中間調査35％（n=51）」で、有意差を認めた（p<0.05）。 4.活動を行っていない主な理由の内、「業務との両立困難」「方法が分からない」「活動の場がない」とした割合の合計は「初回調査70％（n=51）、中間調査73％（n=33）」で変化はなかった。 5.今後サポート活動を行いたい会員の割合は「初回調査72％（n=57）、中間調査94％（n=31）」で、有意差を認めた（p<0.05）。 6.理学療法士として宮崎県のサポート活動に貢献したい会員の割合は「初回調査89％（n=57）、中間調査96％（n=50）」で、有意差は認めなかった。 【考察】 今回の調査からMTS会員は、サポート活動や宮崎県への貢献度に高い関心と意欲を持っていることが窺えた。一方で、サポート活動が行えない理由の内容から、知識や技術の提供のみでは実際のサポート活動の拡大にはならないということが示唆された。医師をはじめとする他職種との交流や県を中心とするスポーツ関連機関との連携により、我々の認知度を高めながら活動現場を確保していくこともMTSが果たす役割であると思われた。 宮崎県士会における現在のサポート活動の流れは、平成13年より宮崎県体育協会（以下、県体協）医務班トレーナー帯同活動にアスレティックトレーナー（以下、AT）資格を有する理学療法士の参加が契機となり、スポーツ医科学委員会への委員就任、宮崎大学医学部整形外科教室との研究協力など、種々の県機関との連携が基礎になっている。その経過と実績をMTSの活動に取り込むことにより、会員へのサポート活動の方法論や活動現場の提供が可能になると思われた。既にMTS会員はATを頂点とするネットワークの一員として見込まれており、サポート活動を行う上で個々のスキルの標準化を図るため、宮崎県独自のトレーナー認定資格運用という新たな道筋も見えてきている。 将来、MTS修了会員がそれぞれの生活圏でのサポート活動に挑戦し、MTSによって構築されるネットワークを最大限活用し、県内地域で活動するスポーツに関わる理学療法士という職能の可能性が期待されている。 【理学療法学研究としての意義】 育成の過程で情意活動を捉えるひとつの手段として有用であると同時に、このような取り組みは職能的視点から地域における社会貢献、即ち社会に認知され、県民の健康増進に寄与できるのではないかと期待される。

DOI： 10.14900/cjpt.2009.0.C4P1123.0

特発性側彎症に対するぶら下がり単純X線撮影の意義（共著） Reviewed

黒木浩史, 久保紳一郎, 帖佐悦男, 田島直也

脊柱変形　 24 ( 1 ) 94 - 99 2009.12

Language：Japanese Publishing type：Research paper (scientific journal)

一般診療でスポーツ傷害（外傷・障害）を見逃さないために Reviewed

帖佐悦男

日本医事新報 4462 62 - 68 2009.10

Language：Japanese Publishing type：Research paper (scientific journal)

Long-term results of intertrochanteric valgus osteotomy for bilateral advanced osteoarthritis of the hip

MATSUOKA Tomomi

35 305 - 308 2009.10

Language：Japanese Publishing type：Research paper (scientific journal)

下肢　股関節の痛み Reviewed

帖佐悦男

ペインクリニック 30 ( 10 ) 1331 - 1339 2009.10

Language：Japanese Publishing type：Research paper (scientific journal)

Idiopathic Spinal Epidural Lipomatosis : A Case Report

HIYOSHI Masaru, KUBO Shinichiro, KUROKI Hiroshi, HAMANAKA Hideaki, HANADO Shoji, KAIDA Hiroshi, INOMATA Naoki, YAMAGUCHI Shihoko, CHOSA Etsuo

58 ( 3 ) 411 - 414 2009.9

Language：Japanese Publishing type：Research paper (scientific journal)

前十字靭帯再建術前後の歩行分析（共著） Reviewed

河原勝博, 帖佐悦男, 鳥取部光司, 渡邊信二

臨床バイオメカニクス 30 431 - 435 2009.9

Language：Japanese Publishing type：Research paper (scientific journal)

股関節臼蓋形成不全の応力解析における臼蓋縁形態の影響（共著） Reviewed

鳥取部光司, 帖佐悦男, 趙昕, 渡邊信二, 鄧鋼　

臨床バイオメカニクス 30 209 - 213 2009.9

Language：Japanese Publishing type：Research paper (scientific journal)

臼蓋形成不全に対する寛骨臼骨切り術の応力解析（共著） Reviewed

趙昕, 帖佐悦男, 鳥取部光司, 渡邊信二, 鄧鋼

臨床バイオメカニクス 30 203 - 207 2009.9

Language：Japanese Publishing type：Research paper (scientific journal)

上肢における見過ごされやすいスポーツ外傷・障害

矢野浩明, 帖佐悦男, 山本惠太郎, 石田康行, 河原勝博, 田島卓也, 山口奈美, 崎濱智美

臨床スポーツ医学 = The journal of clinical sports medicine 26 ( 8 ) 975 - 983 2009.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：文光堂

上肢における見過ごされやすいスポーツ外傷・障害-画像診断の特徴とピットフォール-（共著） Reviewed

矢野浩明, 帖佐悦男, 山本惠太郎, 石田康行, 河原勝博, 田島卓也, 山口奈美, 﨑濵智美

臨床スポーツ医学 26 ( 8 ) 975 - 983 2009.8

Language：Japanese Publishing type：Research paper (scientific journal)

見過ごされやすいスポーツ傷害-外傷と障害- Reviewed

帖佐悦男

日本整形外科学会雑誌 83 ( 7 ) 487 - 495 2009.8

Language：Japanese Publishing type：Research paper (scientific journal)

腱板断裂後の棘下筋筋委縮に対する筋電図による検討（共著） Reviewed

石田康行, 帖佐悦男, 矢野浩明, 﨑濵智美

肩関節 33 ( 2 ) 463 - 465 2009.7

Language：Japanese Publishing type：Research paper (scientific journal)

MX-2000ステム使用3年経過例の検討（共著） Reviewed

坂本武郎, 帖佐悦男, 渡邊信二, 関本朝久, 濱田浩朗, 野崎正太郎, 前田和徳, 中村嘉宏, 舩元太郎

第17回MX人工股関節研究会記録集 49 - 52 2009.7

Language：Japanese Publishing type：Research paper (scientific journal)

前十字靭帯損傷患者のジョギングにおける動作分析 : 関節弛緩性の有無での比較

河原勝博, 帖佐悦男, 鳥取部光司, 山本惠太郎, 田島卓也, 宮崎茂明

運動療法と物理療法 = The Journal of physical medicine 20 ( 2 ) 2009.6

Language：Japanese Publishing type：Research paper (scientific journal)

宮崎県で開催された高校ラグビー競技会に対する安全度評価（共著） Reviewed

吉川大輔, 帖佐悦男, 山本惠太郎, 田島卓也

九州・山口スポーツ医・科学会誌 21 135 - 139 2009.6

Language：Japanese Publishing type：Research paper (scientific journal)

側彎症診療における腹皮反射の意義（共著） Reviewed

黒木浩史, 猪俣尚規, 久保紳一郎, 濱中秀昭, 花堂祥治, 帖佐悦男　

西日本脊椎研究会誌 35 ( 1 ) 2 - 5 2009.6

Language：Japanese Publishing type：Research paper (scientific journal)

環軸椎亜脱臼に対するGoel(Harms)technique（共著） Reviewed

濱中秀昭, 久保紳一郎, 黒木浩史, 花堂祥治, 猪俣尚規, 桐谷　力, 小島岳史, 福島克彦, 近藤梨紗, 帖佐悦男

宮崎整形外科懇話会論文集 ( 13 ) 23 - 25 2009.6

Language：Japanese Publishing type：Research paper (scientific journal)

認知症患者の大腿骨転子部骨折に対する術後予後の比較検討?重症度別の比較検討?（共著） Reviewed

公文崇詞, 園田典生, 帖佐悦男　

宮崎整形外科懇話会論文集 ( 13 ) 5 - 7 2009.6

Language：Japanese Publishing type：Research paper (scientific journal)

Prognosis of trochanteric fractures of the femur in dements

KUMON T., SONODA N., CHOSA E.

31 ( 2 ) 399 - 401 2009.5

Language：Japanese Publishing type：Research paper (scientific journal)

認知症患者の大腿骨転子部骨折に対する術後予後の比較検討?重症度別の比較検討?（共著） Reviewed

公文崇詞, 園田典生, 帖佐悦男　

骨折 31 ( 2 ) 399 - 401 2009.5

Language：Japanese Publishing type：Research paper (scientific journal)

見過ごされやすいスポーツ傷害-外傷と障害-（共著） Reviewed

帖佐悦男

マルホ整形外科セミナー 193 24 - 30 2009.3

Language：Japanese Publishing type：Research paper (scientific journal)

Clinical Result of Microsurgical Posterior Foraminotomy with Laminoplasty for Cervical Spondylotic Amyotrophy

KONDO Risa, KUBO Shinichiro, KUROKI Hiroshi, HANADO Shoji, HAMANAKA Hideaki, INOMATA Naoki, KAIDA Hiroshi, KOJIMA Takeshi, FUKUSHIMA Katsuhiko, CHOSA Etsuo

58 ( 2 ) 245 - 248 2009.3

Language：Japanese Publishing type：Research paper (scientific journal)

Anterior Cruciate Ligament Reconstruction for Middle-Aged Female Patients Reviewed

58 ( 2 ) 192 - 198 2009.3

Language：Japanese Publishing type：Research paper (scientific journal)

当科における中高年女性に対する膝十字靭帯再建術の治療成績（共著） Reviewed

山口志保子, 山本惠太郎, 矢野浩明, 河原勝博, 石田康行, 田島卓也, 三橋龍馬, 帖佐悦男

整形外科と災害外科別冊 58 ( 2 ) 192 - 198 2009.3

Language：Japanese Publishing type：Research paper (scientific journal)

棘窩切痕部ガングリオンに対する肩峰下滑液包からの鏡視下除圧術（共著） Reviewed

石田康行, 帖佐悦男, 矢野浩明, 山本惠太郎, 河原勝博, 田島卓也

整形外科 60 ( 2 ) 155 - 160 2009.2

Language：Japanese Publishing type：Research paper (scientific journal)

棘窩切痕部ガングリオンに対する肩峰下滑液包からの鏡視下除圧術（共著） Reviewed

石田康行, 帖佐悦男, 矢野浩明, 山本惠太郎, 河原勝博, 田島卓也

整形外科 60 ( 2 ) 155 - 160 2009.2

Language：Japanese Publishing type：Research paper (scientific journal)

学校における運動器検診モデル事業の成果と課題 : 宮崎県

山本惠太郎, 帖佐悦男

臨床スポーツ医学 = The journal of clinical sports medicine 26 ( 2 ) 171 - 181 2009.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：文光堂

学校における運動器検診モデル事業の成果と課題-宮崎県-（共著） Reviewed

山本惠太郎, 帖佐悦男

臨床スポーツ医学 26 ( 2 ) 171 - 181 2009.2

Language：Japanese Publishing type：Research paper (scientific journal)

変形性膝関節症に対する運動療法とヒアルロン酸の短期臨床効果の検討 Reviewed

鳥取部光司, 帖佐悦男, 田邉龍樹, 迫田勇一郎, 河原勝博

運動・物理療法 20 ( 1 ) 28 - 32 2009.1

Language：Japanese Publishing type：Research paper (scientific journal)

鏡視下腱板修復術後における理学療法の追跡調査

宮崎茂明, 石田康行, 帖佐悦男, 鳥取部光司, 日高隆, 新藤灯子, 渡辺将成, 屋嘉部愛子, 大城雅哉, 後藤由佳

日本理学療法学術大会 2008 ( 0 ) C3P1387 - C3P1387 2009

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：JAPANESE PHYSICAL THERAPY ASSOCIATION

【目的】鏡視下腱板修復術（Arthroscopic Rotator Cuff Repair：ARCR）後の理学療法が術後成績に及ぼす影響を明らかにする目的で、術後成績と成績に影響を及ぼす因子について経時的に調査したので報告する． 【対象】2007年6月から2007年12月に、当院にてARCRを施行し、9ケ月以上経過観察が可能であった20例20肩を対象とした．内訳は、男性18肩、女性2肩で、手術時平均年齢は61．7歳（51～73歳）であった．対象には本研究の目的と内容を説明し、同意を得た後、測定を行った． 【方法】評価法としては、術前、術後3ヶ月、6ヶ月、9ヶ月の、日整会肩関節疾患治療成績判定基準(JOAスコア)、American Shoulder and Elbow Surgeons（ASES）shoulder index、 University of California at Los Angeles（UCLA） rating scaleを使用し、スコアの推移について検討した．統計学的検討にはFriedman順位検定およびBonferroni補正Wilcoxon検定を用い、危険率1％未満を有意差ありとした． 【結果】JOAスコアの推移は、術前より術後6ヶ月で57.25点から89点（中央値）と改善し、統計学的有意差を認めた．また、各項目別のスコアの推移は、疼痛スコアで術前から術後3ヶ月で有意に改善した．機能スコアは、術前から術後6ヶ月の各期間で有意に改善した．可動域スコアは、術後3から6ヶ月で有意に改善した．ASES shoulder indexの推移は、術前より術後6ヶ月で29点から82点と改善し、統計学的有意差を認めた．また、各項目別のスコアの推移は、疼痛スコアで術前から術後3ヶ月で有意に改善した．機能スコアは、術前から術後6ヶ月の各期間で有意に改善した．UCLA rating scaleの推移は、術前より術後6ヶ月で12点から27.5点と改善し、統計学的有意差を認めた．また、各項目別のスコアの推移は、疼痛、筋力、可動域の各スコアにおいて術前から術後3ヶ月で有意に改善した．機能スコアは、術前から術後6ヶ月の各期間で有意に改善した． 【考察】今回の結果より、術後理学療法の効果は術後6ヶ月までの術後成績に強く影響を及ぼしていることが示唆された．また、疼痛と筋力が術後3ヶ月まで、機能と可動域が術後6ヶ月まで有意な改善を示した．このことから、筋力改善にはARCRによる解剖学的連続性の再獲得により、腱板相互の筋収縮を可能にしたことが、機能と可動域改善には、肩甲骨固定化機能の改善が影響を及ぼしていると推察され、腱板機能と肩甲胸郭関節機能の神経筋協調性獲得を考慮した理学療法の実施が重要であると考えられる．

DOI： 10.14900/cjpt.2008.0.C3P1387.0

Safe and Simple Techniques for Cervical Pedicle Screw Insertion

KUBO Shinichiro

19 ( 4 ) 719 - 723 2008.12

Language：Japanese Publishing type：Research paper (scientific journal)

総説

帖佐悦男

臨床スポーツ医学 = The journal of clinical sports medicine 25 ( 12 ) 1343 - 1344 2008.12

Language：Japanese Publishing type：Research paper (scientific journal)

安全かつ簡便な頸椎椎弓根スクリューの刺入手技（共著） Reviewed

久保紳一郎, 帖佐悦男, 黒木浩史, 花堂祥治, 濱中秀昭

日本脊椎脊髄病学会雑誌 19 ( 4 ) 719 - 723 2008.12

Language：Japanese Publishing type：Research paper (scientific journal)

皮切にこだわらないMIS人工股関節置換術（共著） Reviewed

帖佐悦男, 坂本武郎, 渡邊信二, 関本朝久, 濱田浩朗, 前田和徳, 野﨑正太郎, 中村嘉宏, 舩元太郎, 柏木輝行

Hip Joint 34 479 - 482 2008.11

Language：Japanese Publishing type：Research paper (scientific journal)

臼蓋形成不全症におけるSNP解析（共著） Reviewed

関本朝久, 帖佐悦男, 舩元太郎, 濱田浩朗, 坂本武郎, 渡邊信二, 野﨑正太郎, 前田和徳, 中村嘉宏

Hip Joint 34 520 - 523 2008.11

Language：Japanese Publishing type：Research paper (scientific journal)

SNP finding analysis of the acetabular dysplasia

SEKIMOTO Tomohisa

34 520 - 523 2008.11

Language：Japanese Publishing type：Research paper (scientific journal)

Thurapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits. "jointly worked" Reviewed

Toshiyuki Okura, Kousuke Marutsuka, Hiroaki Hamada, Tomohisa Sekimoto, Tsuyoshi Fukushima, Yujiro Asada, Kazuo Kitamura, Etsuo Chosa

Arthritis Research & Therapy 10 ( 6 ) R133 - R142 2008.11

Language：English Publishing type：Research paper (scientific journal)

Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits

Okura T., Marutsuka K., Hamada H., Sekimoto T., Fukushima T., Asada Y., Kitamura K., Chosa E.

Arthritis Research and Therapy 10 ( 6 ) R133 2008.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Arthritis Research and Therapy

Introduction: Adrenomedullin is a potent vasodilatory and hypotensive peptide as well as an endogenous immunomodulatory factor with predominantly anti-inflammatory effects. The purpose of the present study was to evaluate the therapeutic effects of adrenomedullin in rabbits with antigen-induced arthritis, an experimental model of rheumatoid arthritis. Methods: Following the induction of arthritis in both knee joints by ovalbumin injection into the joint spaces of pre-immunized rabbits, increasing daily doses of adrenomedullin were injected into the knee joint spaces or saline was injected into the contralateral knee joint spaces as the control. For time-course experiments, adrenomedullin and saline were injected into the knee joint spaces daily for 7 days and 20 days. The degree of joint swelling and the histological change in the knee joints injected with adrenomedullin were compared with the control knee joints. Histological evaluation of the infrapatellar fat pads and synovial tissue was performed. TNFα, IL-6, vascular endothelial growth factor and transforming growth factor-beta mRNA levels in the synovial tissue were measured using real-time quantitative PCR. Results: Daily injections of adrenomedullin into the knee joint spaces of rabbits with antigen-induced arthritis decreased joint swelling. Histological examination revealed that adrenomedullin reduced edematous changes and the infiltration of inflammatory cells in the synovial tissues. Analysis of mRNA levels showed that adrenomedullin significantly reduced TNFα mRNA expression by 21% to 49% in a dose-dependent manner, and dose-dependently increased IL-6 mRNA expression by 45% to 121%. Conclusions: These results suggest that daily injections of adrenomedullin into the knee joint spaces of rabbits with antigen-induced arthritis ameliorated the inflammatory response in arthritic joints. Adrenomedullin may thus be useful as a treatment for rheumatoid arthritis; however, the effect of adrenomedullin on IL-6 production in the synovial tissue may be an undesirable adverse effect in rheumatoid arthritis therapy. © 2008 Okura et al.; licensee BioMed Central Ltd.

DOI： 10.1186/ar2550

Stress analysis of the glenohumeral joint using the three-dimensional finite element method

3次元有限要素法による肩関節の応力解析（共著） Reviewed

井上篤, 後藤啓輔, 田島直也, 帖佐悦男

日本臨床バイオメカニクス学会誌 29 77 - 80 2008.11

Language：Japanese Publishing type：Research paper (scientific journal)

Finite element analysis on the acetabular labrum Reviewed

Koji TOTORIBE,MD.,Etsuo CHOSA,MD.,Xin ZHAO,Shinji WATANABE,MD.,Gang DENG,PhD.

29 317 - 320 2008.11

Language：Japanese Publishing type：Research paper (scientific journal)

Finite element analysis on the acetabular head coverage Reviewed

Xin ZHAO,Etsuo CHOSA,MD.,KojiTOTORIBE,MD.,Shinji WATANABE,MD.,GangDENG,PhD.

29 321 - 324 2008.11

Language：Japanese Publishing type：Research paper (scientific journal)

INOUE Atsushi, GOTO Keisuke, TAJIMA Naoya, CHOSA Etsuo

29 77 - 80 2008.11

Language：Japanese Publishing type：Research paper (scientific journal)

Orthopaedic medical care in the provinces in the near future Reviewed

The Journal of the Japanese Orthopaedic Association 82 ( 10 ) 868 - 870 2008.10

Language：Japanese Publishing type：Research paper (scientific journal)

【上肢の外科　最近の進歩】手関節・手疾患の治療　母指手根中手変形性関節症の治療　母指手根中手関節症に対する固定術の経験（共著） Reviewed

﨑濵智美, 矢野浩明, 帖佐悦男

別冊整形外科 ( 54 ) 199 - 202 2008.10

Language：Japanese Publishing type：Research paper (scientific journal)

腰痛症に対するジブカイン塩酸塩配合薬によるトリガーポイント注射の治療効果（共著） Reviewed

公文崇詞, 久保伸一郎, 黒木浩史, 濱中秀昭, 帖佐悦男

整形・災害外科 51 ( 11 ) 1477 - 1481 2008.10

Language：Japanese Publishing type：Research paper (scientific journal)

Expression of hepatocyte growth factor activator inhibitor type 1 on the epithelial cell surface is regulated by hypoxic and oxidative stresses

Komaki W., Komaki W., Fukushima T., Tanaka H., Itoh H., Chosa E., Kataoka H.

Virchows Archiv 453 ( 4 ) 347 - 357 2008.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Virchows Archiv

Hepatocyte growth factor activator inhibitor type 1 (HAI-1)/spint-1 is a membrane-bound protease inhibitor that is thought to regulate the activities of hepatocyte growth factor activator, matriptase, hepsin, and prostasin. In this study, we show that the membrane form of HAI-1 was significantly upregulated immunohistochemically in epithelial cells under adverse conditions including tissue injury, necroinflammatory reactions, and invasion of carcinomas. To analyze the mechanism underlying these in vivo observations, we examined the effects of hypoxia and oxidative stress on HAI-1 expression in vitro, using three human cell lines, HLC-1, WiDr, and HeLa. Hypoxic condition significantly enhanced the expression of HAI-1 in these cells. Oxidative stress also enhanced HAI-1 expression. Promoter analyses of the human HAI-1/spint-1 gene revealed overlapping binding site for Egr-1-3 and Sp1 near the transcription start site as the key domain for HAI-1/spint-1 transcription. This site was also critical in both hypoxic- and oxidative stress-induced HAI-1 upregulation. In fact, in vivo immunohistochemical studies indicated that areas with HAI-1 upregulation tended to express markers associated with hypoxia and oxidative stress. These observations suggest that the tissue microenvironment regulates the cell surface expression of HAI-1, and thereby may regulate proteolysis and processing of bioactive molecules on the cellular surface. © 2008 Springer-Verlag.

DOI： 10.1007/s00428-008-0662-1

Lumbar Ligamentum Flavum Hematoma : A Case Report

KOJIMA Takeshi, KUROKI Hiroshi, HAMANAKA Hideaki, KUBO Shinichiro, HANADO Shoji, INOMATA Naoki, KIRIYA Riki, FUKUSHIMA Katsuhiko, KOMAKI Wataru, CHOSA Etsuo

57 ( 4 ) 567 - 571 2008.9

Language：Japanese Publishing type：Research paper (scientific journal)

Expression of 　hepatocyte growth factor inhibitor type 1 on the epithelial cellsurface is regulated by hypoxic and oxidative. "jointly worked" Reviewed

Wataru Komaki, Tsuyoshi Fukushima, Hiroyuki Tanaka, Hiroshi Itoh, Etsuo Chosa, Hiroaki Kataoka

Virchows Arch 453 347 - 357 2008.9

Language：English Publishing type：Research paper (scientific journal)

反復性肩関節脱臼を呈する骨性Bankart病変に対する鏡視下修復術 Reviewed

石田康行, 帖佐悦男, 矢野浩明, 山本惠太郎, 河原勝博, 田島卓也, 﨑濵智美, 三橋龍馬

宮崎県医師会医学会誌 32 ( 2 ) 78 - 85 2008.9

Language：Japanese Publishing type：Research paper (scientific journal)

腰椎黄色靭帯内血腫の1例（共著） Reviewed

小島岳史, 黒木浩史, 濱中秀昭, 久保紳一郎, 花堂祥治, 猪俣尚規, 桐谷力, 福島克彦, 小牧亘, 帖佐悦男

整形外科と災害外科 57 ( 4 ) 567 - 571 2008.9

Language：Japanese Publishing type：Research paper (scientific journal)

Bilateral congenital separation of the lateral meniscus. A case report Reviewed

Komatsu, N., Yamamoto,K., Chosa, E.

The Knee 15 ( 4 ) 330 - 332 2008.8

Language：English Publishing type：Research paper (scientific journal)

Safety evaluation for rugby-football competitions held in the Kyushu area Reviewed

16 ( 3 ) 402 - 407 2008.8

Language：Japanese Publishing type：Research paper (scientific journal)

Pathological Finding og The Excised Synovial Tissue under Administration of Inflixibmab in The Patient with Rheumatoid Arthritis, Compared with The Past Specimens: A Case Report Reviewed

27 ( 2 ) 171 - 175 2008.7

Language：Japanese Publishing type：Research paper (scientific journal)

皮切にこだわらないMIS人工股関節置換術（共著） Reviewed

帖佐悦男, 坂本武郎, 渡邊信二, 関本朝久, 濱田浩朗, 前田和徳, 野崎正太郎, 中村嘉宏, 舩元太郎, 柏木輝行

第16回MX人工股関節研究会記録集 81 - 84 2008.7

Language：Japanese Publishing type：Research paper (scientific journal)

MX-2000ステムの検討（共著） Reviewed

坂本武郎, 帖佐悦男, 渡邊信二, 関本朝久, 濱田浩朗, 野崎正太郎, 前田和徳, 中村嘉宏, 舩元太郎

第16回MX人工股関節研究会記録集 49 - 52 2008.7

Language：Japanese Publishing type：Research paper (scientific journal)

遅発性筋痛症に対する消炎鎮痛スプレー剤の効果についての検討（共著） Reviewed

三橋龍馬, 帖佐悦男, 山本惠太郎, 河原勝博, 田島卓也

九州・山口スポーツ医・科研究会誌 20 58 - 62 2008.6

Language：Japanese Publishing type：Research paper (scientific journal)

1-3-2 変形性膝関節症に対するヒアルロン酸製剤と運動療法の評価検討(骨関節(下肢),口演,一般演題,リハビリテーション医学の進歩"評価から治療介入へ",第45回日本リハビリテーション医学会学術集会)

鳥取部光司, 帖佐悦男, 濱田浩朗, 坂本武郎, 野崎正太郎, 河原勝博, 川野啓一郎

リハビリテーション医学 : 日本リハビリテーション医学会誌 45 ( 0 ) 2008.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：社団法人日本リハビリテーション医学会

Surgical Result of Arthroscopic Rotator Cuff Repair : a view of operative indications

ISHIDA Yasuyuki, CHOSA Etsuo, YANO Hiroaki, YAMAMOTO Keitaro, KAWAHARA Katsuhiro, TAJIMA Takuya

33 ( 2 ) 153 - 158 2008.4

Language：Japanese Publishing type：Research paper (scientific journal)

腰痛症に対するジブカイン塩酸塩配合薬によるトリガーポイント注射の治療効果（共著） Reviewed

公文崇詞, 久保紳一郎, 黒木浩史, 濱中秀昭, 帖佐悦男

整形・災害外科 51 ( 11 ) 1477 - 1481 2008.4

Language：Japanese Publishing type：Research paper (scientific journal)

手術適応別の鏡視下腱板修復術の成績（共著） Reviewed

石田康行, 帖佐悦男, 矢野浩明, 山本惠太郎, 河原勝博, 田島卓也

関節鏡 33 ( 2 ) 153 - 158 2008.4

Language：Japanese Publishing type：Research paper (scientific journal)

特発性側彎症患者における装具装着状況の検討（共著） Reviewed

黒木浩史, 久保伸一郎, 帖佐悦男, 田島直也

日本側彎症学会 22 ( 1 ) 42 - 46 2008.4

Language：Japanese Publishing type：Research paper (scientific journal)

モアレ法による側彎症学校検診の検証　-小学5年時検診陰性，中学2年時検診陽性症例の解析-（共著） Reviewed

黒木浩史, 久保紳一郎, 帖佐悦男, 田島直也

The Journal of Japanese Scoliosis Society 23 ( 1 ) 14 - 19 2008.4

Language：Japanese Publishing type：Research paper (scientific journal)

環軸椎亜脱臼に対するGoel-Harms technique Reviewed

樋口誠二，猪俣尚規，桐谷力，濱中秀昭，花堂祥治，黒木浩史，久保紳一郎，帖佐悦男

整形外科と災害外科 57 ( 2 ) 211 - 217 2008.3

Language：Japanese Publishing type：Research paper (scientific journal)

当科でのオーバーヘッドトラクションによる先天性股関節脱臼の治療経験 Reviewed

小牧ゆか，帖佐悦男，坂本武郎，関本朝久，渡邊信二，濱田浩朗，野﨑正太郎，前田和徳，中村嘉宏，舩元太郎

整形外科と災害外科 57 ( 2 ) 242 - 247 2008.3

Language：Japanese Publishing type：Research paper (scientific journal)

当科でのオーバーヘッドトラクションによる先天性股関節脱臼の治療経験 Reviewed

小牧ゆか，帖佐悦男，坂本武郎，関本朝久，渡邊信二，濱田浩朗，野﨑正太郎，前田和徳，中村嘉宏，舩元太郎

整形外科と災害外科 57 ( 2 ) 242 - 247 2008.3

Language：Japanese Publishing type：Research paper (scientific journal)

Image diagnosis of arthrosis of the hip joint Reviewed

Journal of Joint Surgery 27 ( 6 ) 23 - 30 2008.1

Language：Japanese Publishing type：Research paper (scientific journal)

合併したC型慢性肝炎にインターフェロンを投与した関節リウマチの1例 Reviewed

税所幸一郎,有住祐一, 江夏剛, 加藤順也, 帖佐悦男

九州リウマチ 28 ( 1 ) 32 - 37 2008.1

Language：Japanese Publishing type：Research paper (scientific journal)

Pathological Findings of The Excised Synovial Tissue under Administration of Infliximab in The Patient with Rheumatoid Arthritis, Compared with The Past Specimens: A Case Report

FUNAMOTO Taro

Japanese Journal of Joint Diseases 27 ( 2 ) 171 - 175 2008

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Joint Diseases

Treatment of anti-tumor necrosis factor-alpha (TNF-α) antibody has been administered to patients with Rheumatoid Arthritis (RA) . Anti-TNF α therapy is effective for most of RA patients, however, joint symptoms last with some cases. In these years, some reports have mentioned that synovectomy is one of the effective methods for such cases. We report that synovectomy was useful for the patient having polyarthralgia despite infliximab treatment, and inflammatory cell infiltration decreased in the synovial tissue compared with the past specimens. The patient was 50 years old woman who was diagnosed as RA in 1986. She was treated by prednisolone and methotrexate (MTX), and attained remission once. In 2001, however, she was diagnosed as RA due to reappearance of polyarthritis again. She began to take prednisolone at 10mg in a day because she hoped pregnancy. For her symptoms became worse, we performed synovectomy in 2002. After the delivery, she began to take MTX at 8 mg in a week in 2005, and then infliximab therapy was administered to her in 2006. Her CRP (C-reactive protein) level had decreased by this therapy, but joint swelling and tenderness still lasted. Therefore, we performed synovectomy for some joints which had been severely swollen. In the pathological findings of this excised synovial tissue, it was observed that synovia increase and inflammatory cells infiltrate. However, compared with the specimens of synovial tissue excised four years ago, the degree of the cell infiltration decreased. After that synovectomy, her symptoms and DAS28-CRP score improved. Thus, it is supposed that decrease of cell infiltration into synovial tissue is an evidence of inf liximab treatment being effective, and to raise an efficacy of that therapy, synovectomy is one of the useful methods.

DOI： 10.11551/jsjd2008.27.171

循環器疾患に対する維持期リハビリテーションの実態調査:通所リハビリテーション施設へのアンケート調査

花田智, 帖佐悦男, 鳥取部光司, 濱田浩朗, 日高隆, 宮﨑茂明

日本理学療法学術大会 2007 ( 0 ) D1249 - D1249 2008

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：公益社団法人日本理学療法士協会

【目的】本県における維持期リハビリの中心的な施設の1つである通所リハビリテーション（以下通所リハ）において、維持期における循環器疾患へのリハビリ（以下循環器リハ）の現状を明らかにすることである。 【方法】宮崎県PT会員名簿・WAM－NETより抽出した41施設へ、郵送による自記式アンケート調査を実施した。調査項目は、「運動前・中のモニタリングの項目」「運動処方の項目」を調査し、更に「循環器リハの経験の有無」による紹介状の「項目」「活用方法」との関連を、クロス集計及びχ2検定により評価し、危険率5％未満を有意とした。 【結果】回収率は80％であり、32施設65人より回答を得た。循環器リハ経験者は29％、PT経験年数は平均6.19±3.7年であった。循環器リハ実施者中、「運動前・運動中モニタリング」を実施している人は84％であり、細目は、運動前が血圧（100％）・脈拍（94％）息切れ等（88％）であり、運動中は自覚症状（100％）顔色等（94％）脈拍（88％）をモニターしていた。運動処方作成は53％が実施しており、細目はBorg指数（90％）・Karvonenの式等（50％）であった。紹介状の必要性は全員が感じており、「循環器リハの経験の有無」と「紹介状の各項目」においては関連を認めなかったが、活用方法で「リスクマネジメントへの活用」において関連を認めた。 【考察】今回の結果から、モニタリングに関して、上村らの報告と同様に脈拍変動は継時的な変化を追っていたものの、運動中は自覚症状などの主観的評価を主に実施していることが明らかとなった。運動処方作成が50％であったが、細目でBorg指数が最も多かった事と合わせると、運動強度は主観的評価により多く決定されていることが示唆された。これらの理由として、主観的評価が血圧などの客観的評価と比べて瞬時に判断できること、PTのマンパワー不足が考えられる。しかし、主観的評価が必ずしも患者の状態を捉えているとは言い難く、山田らは慢性心不全では、特に運動中の血圧反応と不整脈をモニタリングする必要があると言っている。今後は客観的評価の実施と合わせて、より正確な運動による循環動態状況を捉えていく必要があると考える。紹介状は、経験者ほどリスクマネジメントへの意識が高いことが伺え、疾病管理状況のモニタリングの参考として非常に有意義に活用されていることが示唆される。特に、通所リハでは施設の性格上、病院の様な豊富な検査データは獲得しづらい。よって、紹介状の情報が、患者の循環器リハにおける運動処方に非常に大きな役割を果たす。維持期循環器リハの重要性は近年言われてきている。安全性を高める為の客観的モニタリングとPT間の情報交換が、今後循環器リハを行うPTが増加するためにも必要であることが伺える。

DOI： 10.14900/cjpt.2007.0.D1249.0

Compliance of Brace Treatment for Patients with Idiopathic Scoliosis

KUROKI Hiroshi

22 ( 1 ) 42 - 46 2007.12

Language：Japanese Publishing type：Research paper (scientific journal)

Pharmaceutical Skill Using Displacement of Protein Binding for Pharmacists

TAKAMURA Norito, TOKUNAGA Jin, CHOSA Etsuo, KAWAI Keiichi, FUJITA Ken-ichi, ARIMORI Kazuhiko

YAKUGAKU ZASSHI 127 ( 11 ) 1805 - 1811 2007.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Society of Japan

In pharmacotherapy, to alleviate pains of patients and to provide comforts to patients, pharmacists should improve their pharmaceutical skills of their clinical sense involving pharmaceutical investigational outcomes. Without pharmaceutical skills, pharmacists cannot apply the essence of drug therapies for patients in the most urgent 24 hours treatment. To cope with these drug therapies, we have developed search methods which easily identify the diachronic change of protein binding and the factors in serum (=a new pharmaceutical distribution diagnostic method). This method can speculate diachronic change factors in serum, by monitoring diachronically binding capacities of drug binding sites on human serum albumin (HSA) and α1-acid glycoprotein (AGP) molecules in patient sera (add each site probe to each patient serum, and measure the free level of each probe by using TDX/FLX® analyzer and HPLC detector), and considering the binding capacities and values of HSA, AGP, free fatty acids, bilirubin (Bil) and blood urea nitrogen (BUN) associating with the amounts of uremic toxins laboratory tests. In addition, the diagnostic method could attempt effective administration by using the protein binding displacement of drugs that have a high protein binding capacity and small distribution volume, or high targeting (=the pharmaceutical skill of protein binding displacement). We have practiced pain control of patients with rheumatoid arthritis by the pharmaceutical skill. It is important for pharmacists to master the pharmaceutical skill in pharmacotherapy.

DOI： 10.1248/yakushi.127.1805

[Need for pharmaceutical skill in using displacement of protein binding].

Takamura N, Tokunaga J, Chosa E, Kawai K, Fujita K, Arimori K

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 127 ( 11 ) 1805 - 11 2007.11

Language：Japanese Publishing type：Research paper (scientific journal)

3-P2-40 前十字靭帯損傷膝に対する歩行分析(骨関節疾患・運動学運動生理学,ポスター,一般演題,実学としてのリハビリテーションの継承と発展,第44回日本リハビリテーション医学会学術集会)

エビデンスに基づいたアキレス腱断裂の診断手順

帖佐悦男, 山本惠太郎, 河原勝博, 園田典生

臨床スポーツ医学 = The journal of clinical sports medicine 24 ( 10 ) 1057 - 1064 2007.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：文光堂

エビデンスに基づいたアキレス腱断裂の診断手順 Reviewed

帖佐悦男,山本惠太郎,河原勝博,園田典生

臨牀スポーツ医学 24 ( 10 ) 1057 - 1064 2007.10

Language：Japanese Publishing type：Research paper (scientific journal)

皮切りにこだわらないMIS人工関節置換術 Reviewed

帖佐悦男,坂本武郎,渡邉信二,関本朝久,濱田浩朗,前田和徳,野崎正太郎,中村嘉宏,舩元太郎,柏木輝行

MX人工股関節研究会 2007.7

Language：Japanese Publishing type：Research paper (scientific journal)

MX-2000ステムの検討 Reviewed

坂本武郎,帖佐悦男,渡邊信二,関本朝久,濱田浩朗,野崎正太郎,前田和徳,中村嘉宏,舩元太郎

MX人工股関節研究会 2007.7

Language：Japanese Publishing type：Research paper (scientific journal)

緩みが原因で前十字靱帯再々建術を行った症例の検討

河原勝博, 帖佐悦男, 鳥取部光司, 田島直也

運動療法と物理療法 = The Journal of physical medicine 18 ( 2 ) 2007.6

Language：Japanese Publishing type：Research paper (scientific journal)

棘突起縦割式脊柱管拡大術の術後成績とHAスペーサーの改良 Reviewed

濱中秀昭, 久保紳一郎, 黒木浩史, 花堂祥治, 桐谷力, 黒木修司, 帖佐悦男

西日本脊椎研究会誌 33 ( 1 ) 29 - 34 2007.6

Language：Japanese Publishing type：Research paper (scientific journal)

ラグビー競技における宮崎大学式大会安全度評価について　ラグビー現場におけるAEDの必要性も含め Reviewed

中村嘉宏, 帖佐悦男, 山本恵太郎, 河原勝博, 田島卓也, 吉川大輔, 吉川教恵

九州・山口スポーツ医・科研究会誌 19 144 - 149 2007.6

Language：Japanese Publishing type：Research paper (scientific journal)

医学部ラグビー部員引退後の頸椎変化 Reviewed

中村嘉宏, 帖佐悦男, 山本恵太郎, 河原勝博, 田島卓也, 吉川大輔, 吉川教恵

九州・山口スポーツ医・科研究会誌 19 133 - 137 2007.6

Language：Japanese Publishing type：Research paper (scientific journal)

腰部脊柱管狭窄症に対する顕微鏡視下拡大開窓術の術後成績 Reviewed

桐谷力, 久保紳一郎, 黒木浩史, 濱中秀昭, 花堂祥治, 甲斐糸乃, 帖佐悦男

西日本脊椎研究会誌 33 ( 1 ) 158 - 162 2007.6

Language：Japanese Publishing type：Research paper (scientific journal)

椎弓根スクリューを用いた頸椎後方固定術の経験 Reviewed

久保紳一郎, 黒木浩史, 花堂祥治, 桐谷力, 黒木修司, 帖佐悦男

西日本脊椎研究会誌 33 ( 1 ) 65 - 70 2007.6

Language：Japanese Publishing type：Research paper (scientific journal)

河原勝博, 帖佐悦男, 鳥取部光司, 濱田浩朗, 山本惠太郎

リハビリテーション医学 : 日本リハビリテーション医学会誌 44 ( 0 ) 2007.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：社団法人日本リハビリテーション医学会

特発性側弯症患者における装具装着状況の検討 Reviewed

黒木浩史，久保紳一郎，帖佐悦男，田島直也

脊柱変形 22 42 - 46 2007.4

Language：Japanese Publishing type：Research paper (scientific journal)

Treatment of Giant Bone Defect for Osteofibrous Dysplasia with Only β-TCP:3 Case Reports Reviewed

Orthopedics & Traumatology 56 ( 3 ) 458 - 461 2007.4

Language：Japanese Publishing type：Research paper (scientific journal)

薬剤師が"薬術"を獲得することの重要性 : 薬学的分布診断法（血清内探索法）と攻めの薬物投与法

髙村徳人,德永仁,帖佐悦男,川井恵一,有森和彦,大井一弥

医薬ジャーナル 43 ( 3 ) 963 - 973 2007.3

Language：Japanese Publishing type：Research paper (scientific journal)

Revision arthroplasties for rhematoid knee Reviewed

Koichiro Saisho, Hideho Uchida, Hiroshi Murakami, Yuich Arizumi, Tsuyoshi Enatsu, Koji Totoribe, Etsuo Chosa

Kyushu Rheumatology 26 ( 2 ) 96 - 101 2007.3

Language：Japanese Publishing type：Research paper (scientific journal)

人工膝関節再置換術の経験

税所幸一郎,内田秀穂,村上弘,有住裕一,鳥取部光司,帖佐悦男

九州リウマチ 26 ( 2 ) 96 - 101 2006.12

Language：Japanese Publishing type：Research paper (scientific journal)

Effect on the sagittal alignment of the brace treatment for idiopathic scoliosis

KUROKI Hiroshi

21 ( 1 ) 50 - 55 2006.12

Language：Japanese Publishing type：Research paper (scientific journal)

Meniscus Abnormality (double-layer meniscus and separated meniscus ; a newly meniscus anomaly) in Family

YAMAMOTO Keitaro, CHOSA Etsuo, KOMATSU Nami

31 ( 3 ) 165 - 170 2006.10

Language：Japanese Publishing type：Research paper (scientific journal)

Evaluation of the operated Perthes' disease

SEKIMOTO Tomohisa

32 293 - 297 2006.10

Language：Japanese Publishing type：Research paper (scientific journal)

01P2-153 臨床検査値を薬学的に解釈するための血清内探索法 : 薬学的分布診断法(薬物動態(TDM・投与設計等),医療薬学の扉は開かれた)

高村徳人, 徳永仁, 藤田健一, 帖佐悦男, 緒方賢次, 古屋弓子, 甲斐晃弘, 黒木教彰, 興梠靖幸, 千代反田晋, 日高宗明, 永田将司, 本屋敏郎, 平井正巳, 松岡俊和, 川井恵一, 有森和彦

日本医療薬学会年会講演要旨集 16 2006.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本医療薬学会

Evaluation of knee strength in elite high school athletes

KAWAHARA K., CHOSA E., YAMAMOTO K., TAJIMA N., SONODA N.

Japanese journal of clinical sports medicine 14 ( 3 ) 339 - 345 2006.8

Language：Japanese Publishing type：Research paper (scientific journal)

当科における膝前十字靭帯再建術後の筋力回復の因子について

河原勝博, 帖佐悦男, 鳥取部光司, 田島直也, 樋口潤一

運動療法と物理療法 = The Journal of physical medicine 17 ( 2 ) 2006.6

Language：Japanese Publishing type：Research paper (scientific journal)

アドレノメデュリン

帖佐悦男,濱田浩朗

リウマチ科 35 ( 6 ) 555 - 558 2006.5

Language：Japanese Publishing type：Research paper (scientific journal)

3-6-10 関節リウマチ患者のCHARTによる社会的不利の検討(リウマチ(2),口演,一般演題,リハビリテーション医学の進歩と実践,第43回日本リハビリテーション医学会学術集会)

鳥取部光司, 帖佐悦男, 濱田浩朗, 野崎正太郎, 坂本武郎, 税所幸一郎

リハビリテーション医学 : 日本リハビリテーション医学会誌 43 ( 0 ) 2006.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：社団法人日本リハビリテーション医学会

3-6-11 CHART式評価法を用いた関節リウマチ患者に対する介護に関する検討(リウマチ(2),口演,一般演題,リハビリテーション医学の進歩と実践,第43回日本リハビリテーション医学会学術集会)

野崎正太郎, 帖佐悦男, 鳥取部光司, 濱田浩朗, 坂本武郎

リハビリテーション医学 : 日本リハビリテーション医学会誌 43 ( 0 ) 2006.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：社団法人日本リハビリテーション医学会

Comparative study of hands-on therapy with active exercises vs education with active exercises for the management of upper back pain.

Mary S Pesco,Etsuo Chosa,Naoya Tajima

J Maipulative Physionl 29 ( 3 ) 228 - 235 2006.4

Language：English Publishing type：Research paper (scientific journal)

（脊椎疾患における鑑別診断と治療法選択の根拠）頸椎頸椎症性脊髄症　棘突起縦割式椎弓形成術（double door laminoplasty)の生体力学的根拠 Reviewed

久保紳一郎，帖佐悦男

別冊整形外科 ( 50 ) 62 - 68 2006.4

Language：Japanese Publishing type：Research paper (scientific journal)

Abnormality of Meniscus in Family

55 ( 1 ) 95 - 99 2006.3

Language：Japanese Publishing type：Research paper (scientific journal)

Comparative Study of Hands-On Therapy With Active Exercises vs Education With Active Exercises for the Management of Upper Back Pain

Pesco M., Chosa E., Tajima N.

Journal of Manipulative and Physiological Therapeutics 29 ( 3 ) 228 - 235 2006.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Manipulative and Physiological Therapeutics

Objective: The aim of this study was to compare hands-on therapy, including heat, massage, and active exercises with postural education that emphasized increased self-efficacy and postural self-awareness along with education about the physiology of the disorder, and prescribed daily active exercises. Subjects: Twenty-four randomly selected women, 12 custodians and 12 students, with neck and shoulder pain and stiffness. Methods: All subjects received a medical examination and x-ray before the study to rule out any pre-existing neurologic deficits and an evaluation that included history taking and self-reporting of pain according to a numeric pain scale. Student participants received education and exercise instructions to be continued daily. The custodial workers received once-per-week hands-on treatment. Results: Data were compared using a nonparametric analysis (Wilcoxon signed rank test) and showed evidence of statistically significant reductions in neck, shoulder, and back stiffness and shoulder muscle tension for most of the study subjects. Conclusion: Treatment of repetitive stress injuries that combines maintenance of daily active exercises prescribed and modeled by a professional therapist, which emphasize postural awareness to correct poor posture and provide a basic physiological understanding of the disorder, is as crucial to reducing upper back and neck pain and stiffness as hands-on therapy with active exercise provided in a clinical setting. © 2006 National University of Health Sciences.

DOI： 10.1016/j.jmpt.2006.02.001

Adrenomedullinとpreadrenomedullin N-terminal peptide

帖佐悦男,濱田浩朗

整形外科 57 ( 1 ) 70 - 70 2005.12

Language：English Publishing type：Research paper (scientific journal)

Results of Osaka Medical College (OMC) brace treatment for idiopathic scoliosis

KUROKI Hiroshi

20 ( 1 ) 102 - 110 2005.12

Language：Japanese Publishing type：Research paper (scientific journal)

Hip-spine syndrome : Spinopelvic alignment in secondary hip-spine syndrome

CHOSA Etsuo

Hip Joint 31 235 - 238 2005.10

Language：Japanese Publishing type：Research paper (scientific journal)

Periacetabular osteotomy for treatment of advanced coxarthrosis with large acetabular bone cyst

CHOSA Etsuo

Hip Joint 31 56 - 58 2005.10

Language：Japanese Publishing type：Research paper (scientific journal)

P-202 血清蛋白分子上の各サイトの結合変化を基に血清内の変動要因を推察するための薬学的分布診断法(9.薬物動態(TDM・投与設計等)1,医療薬学の未来へ翔(はばた)く-薬剤師の薬剤業務・教育・研究への能動的関わり-)

高村徳人, 徳永仁, 藤田健一, 帖佐悦男, 奥村学, 山崎啓之, 緒方賢次, 日高宗明, 古屋弓子, 永田将司, 興梠靖幸, 黒木教彰, 甲斐晃弘, 千代反田普, 門田直哉, 本屋敏郎, 平井正巳, 松岡俊和, 川井恵一, 有森和彦

日本医療薬学会年会講演要旨集 15 2005.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本医療薬学会

Safety Evaluation of Rugby Football Competition

TAJIMA Takuya

25 ( 1 ) 2005.6

Language：Japanese Publishing type：Research paper (scientific journal)

Medical Support on High School Karate Players

KAWAHARA Katsuhiro

25 ( 1 ) 2005.6

Language：Japanese Publishing type：Research paper (scientific journal)

Hip joint radiographic technique: radiographic technique for false profile view (a study of optimum foot position)

Kudo M., Ushibana K., Oshikawa M., Shimoshinbara S., Shigaki S., Chosa E.

Nippon Hoshasen Gijutsu Gakkai zasshi 61 ( 5 ) 691 - 700 2005.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Nippon Hoshasen Gijutsu Gakkai zasshi

PURPOSE: To establish a more effective false profile (FP) radiography standard via theoretical consideration of patients' non-inspection-side foot position. PROBLEM: Existing FP radiography admits to two difficulties: 1) A 65-degree pelvic rotation results in differing inter-femoral head distances in individual patients, and 2) the desired angle of rotation of the pelvis is difficult to maintain throughout the examination period. METHOD: The following investigations were performed in this study: 1) inter-femoral head distance using computed tomography (CT) images; 2) optimum outside rotation angle of the non-inspection side for standing comfort; and 3) optimum foot position of the non-inspection side. RESULTS: 1) CT examination revealed an average inter-femoral head distance of 28.7 mm in males and 40.3 mm in females, with a maximum distance of 57.5 mm and minimum distance of 44.1 mm. 2) Investigation established the optimum outside angle of rotation to be 60 degrees. 3) Investigation revealed that the optimum foot position requires that the patient's heel be retracted 3 cm along the axis created by a pelvic rotation of 65 degrees. CT was used to verify the accuracy of the FP view method. CT comparison revealed that X-rays are able to obtain a view quite similar in quality to that of CT. CONCLUSION: It is of utmost importance in FP radiography to establish the optimum foot position for a pelvic rotation value of 65 degrees.

Hip Joint Radiographic Technique : A Radiographic Technique for False Profile View(A Study of Optimum Foot Position)

KUDO MASAKI, USHIBANA KENJI, OSHIKAWA MIWA, SHIMOSHINBARA SHIGERU, SHIGAKI SEIYA, CHOSA ETSUO

Japanese journal of radiological technology 61 ( 5 ) 691 - 700 2005.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Radiological Technology (JSRT)

Purpose : To establish a more effective false profile (FP) radiography standard via theoretical consideration of patients' non-inspection-side foot position. Problem : Existing FP radiography admits to two difficulties : 1) A 65-degree pelvic rotation results in differing inter-femoral head distances in individual patients, and 2) the desired angle of rotation of the pelvis is difficult to maintain throughout the examination period. Method : The following investigations were performed in this study : 1) inter-femoral head distance using computed tomography (CT) images; 2) optimum outside rotation angle of the non-inspection side for standing comfort; and 3) optimum foot position of the non-inspection side. Results : 1) CT examination revealed an average inter-femoral head distance of 28.7 mm in males and 40.3mm in females, with a maximum distance of 57.5 mm and minimum distance of 44.1mm. 2) Investigation established the optimum outside angle of rotation to be 60 degrees. 3) Investigation revealed that the optimum foot position requires that the patient's heel be retracted 3 cm along the axis created by a pelvic rotation of 65 degrees. CT was used to verify the accuracy of the FP view method. CT comparison revealed that X-rays are able to obtain a view quite similar in quality to that of CT. Conclusion : It is of utmost importance in FP radiography to establish the optimum foot position for a pelvic rotation value of 65 degrees.

[Hip joint radiographic technique: radiographic technique for false profile view (a study of optimum foot position)].

Kudo M, Ushibana K, Oshikawa M, Shimoshinbara S, Shigaki S, Chosa E

Nihon Hoshasen Gijutsu Gakkai zasshi 61 ( 5 ) 691 - 700 2005.5

Language：Japanese Publishing type：Research paper (scientific journal)

A Case Report of Lumbar Discal Cyst at L5/S1 Level

MASUDA Hiroshi, KUBO Shinichiro, KUROKI Hiroshi, HAMANAKA Hideaki, GOTO Eiichi, KOJIMA Takeshi, CHOSA Etuo

54 ( 1 ) 56 - 59 2005.3

Language：Japanese Publishing type：Research paper (scientific journal)

Knee Muscle Strength Following Anterior Cruciate Ligament Reconstruction in Female : A Comparison of Bone-Patellar Tendon-Bone Autograft and Semitendinosus-Gracilis Tendon Autograft

FUNAMOTO Taro, CHOSA Etsuo, SONODA Norio, YAMAMOTO Keitaro

Orthopedics & Traumatology 54 ( 2 ) 247 - 250 2005.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

The purpose of this study was to evaluate knee muscle strength following anterior cruciate ligament (ACL) reconstruction in female. We treated 12 female patients with a bone-patellar tendon-bone autograft (BTB) and 29 female patients with a semitendinosus-gracilis autograft (STG) in ACL reconstruction. Knee extensor and flexor strength were measured by KIN-COM before operation, and 3 months, 6 months and 9-12 months after operation. The angular velocity was set at 60 and 180 degrees/second. The results showed that the STG group was better than BTB group on extensor and flexor muscle strength after 3 and 6 months, but there were no significant differences after 9 to 12 months. BTB group patients over 30 years of age showed the worst recovery of extensor muscle strength after 9 to 12 months. The results suggest a delay or deficit in the recovery of knee muscle strength in middle-aged female with BTB in ACL reconstruction.

DOI： 10.5035/nishiseisai.54.247

Evaluation of circulatory compromise in the leg in lumbar spinal canal stenosis.

Chosa E, Sekimoto T, Kubo S, Tajima N

Clinical orthopaedics and related research ( 431 ) 129 - 33 2005.2

Language：Japanese Publishing type：Research paper (scientific journal)

Medical practice in lumbar sports injuries and disorders

Tajima N., Chosa E.

Japan Medical Association Journal 48 ( 1 ) 16 - 19 2005.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Medical Association Journal

In Japan, sports medicine has developed significantly in conjunction with goals to improve athletic levels. Moreover, Japan has become an aging society where promoting health and preventing disease through sports have become commonplace. However, due to the participation by people of all ages in many sports activities, the occurrence of low back pain has increased. Low back pain is classified into several types, and the absence of adequate treatment will have a significant impact on prognosis. Therefore, early and adequate diagnosis of low back pain is very important. When low back pain is caused by sports, the specificity of each sport event should be noted. This paper describes the lumbar sport injuries and disorders such as sprains, fractures of the lumbar vertebrae, disc herniation, spondylolysis, and vertebral end-plate disorder during the growth period. In sports disorders, precise diagnosis and adequate treatment are necessary, and it is essential to avoid continuing treatment aimlessly when symptoms persist.

A Case of Abnormality of the Bilateral Medial Meniscus and Lateral Meniscus

Komatsu Nami, Chosa Etsuo, Sakamoto Takero, Watanabe Shinji, Sekimoto Tomohisa, Hamada Hiroaki, Yamamoto Keitaro, Maeda Kazunori, Yoshikawa Daisuke

Orthopedics & Traumatology 54 ( 4 ) 672 - 675 2005

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

We report a case of abnormality of the bilateral lateral meniscus and medial meniscus. A ten-year-old boy complained of pain and locking of the right knee. On magnetic resonance imaging of the right knee, there was a longitudinal tear on the posterior portion of the lateral meniscus. In arthroscopic findings, the medial meniscus had abnormality of attachment on the anterior portion, and the lateral meniscus comprised of two parts which were completly separeted and duplicated at the midportion. The anterior part was connected to the capsule and the posterior part to the cartilage surface of the tibia plateau at the midportion. We peformed meniscorrhaphy for longitudinal tear on the posterior portion. We checked his left knee for bilateral congental abnormalities. In the arthroscopic findings of the left knee, the shape of the lateral meniscus was almost the same as the right knee, and the medial meniscus had two layers on the anterior portion (double-layers medial meniscus). We found a horizontal tear on the posterior portion, and peformed partial menisectomy on it. We could not find literature on this abnormality of the lateral meniscus and double-layers medial meniscus.

DOI： 10.5035/nishiseisai.54.672

A Case of Osteochondral Autologous Graft Transplantation with Mosaicplasty for Osteochondral Lesion of the Talar Dome

Katsushima Yoko, Chosa Etsuo, Kuroki Ryuji, Yano Hiroaki, Yamamoto Keitaro, Kawahara Katsuhiro, Kono Ryu

Orthopedics & Traumatology 54 ( 3 ) 488 - 492 2005

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

We performed osteochondral grafting with mosaicplasty on a patient diagnosed with ankle sprain in spite of osteochondral lesion of the talar dome. A 14-year-old boy sprained his left ankle during a volleuball practice game when he landed on the floor after spiking the ball and his ankle was forced to a varus position. He was diagnosed with ankle sprain and only prescribed compresses. But because of persistent ankle pain at sports, he consulted our hospital six months after injury. The X-ray films showed osteochondral lesion (Berndt and Harty's classification Stage III ) at the antero-lateral part of the talus. Although we performed a preliminary arthroscopic survey of the ankle and osteochondralsynthesis (PDS pin) for the lesion in combination with autograft transplantation six months after injury, it resulted in nonuinon. We performed osteochondral graft with mosaicplasty on the lesion two years after the first operation and gained good results after the re-operation. When traumatic osteochondral lesion of the talus is diagnosed, it is important to differentiate it from ankle sprain. Osteochondral graft with mosaicplasty seems useful in salvage treatment for osteochondral lesion.

DOI： 10.5035/nishiseisai.54.488

A Case Report: Cauda Equina Syndrome as a Postoperative Complication of Lumbar Disc Herniation

Okura Toshiyuki, Tajima Naoya, Goto Keisuke, Higuchi Junichi, Inoue Atushi, Kubo Shinichiro, Kuroki Hiroshi, Chosa Etuo

Orthopedics & Traumatology 54 ( 4 ) 710 - 713 2005

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

We experienced a case of cauda equina syndrome as a postoperative complication of lumbar disc herniation. The patient was a 57-year-old man and suffered from left leg pain and lumbago. We diagnosed lumbar disc herniation at L4-5 and L5-6 and performed L4-5 and L5-L6 discectomy and posterolateral fusion. Three days after operation, he did not complain of leg pain and lumbago, but he experienced numbness in the perineum and urinary retention. We carried out emergency MR imaging study, but no compressive findings were demonstrated. The patient was expected to recover spontaneously, and numbness in the perineum and urinary retention were resolved three months postoperatively. Vascular insufficiency of the cauda equina was suspected.

DOI： 10.5035/nishiseisai.54.710

3 Case Report of Hypertrophic Pachymeningitis

Fukushima Shuichiro, Chosa Etsuo, Kubo Shinichiro, Kuroki Hiroshi, Hamanaka Hideaki, Kumon Takashi

Orthopedics & Traumatology 54 ( 3 ) 558 - 562 2005

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology

Hypertrophic pachymeningitis is a rare disorder that causes intracranial or spinal thickening of the dura mater. We report three cases of hypertrophic pachymeningitis. All these patients presented symptoms such as back pain, paraparesis, and bladder-bowel disturbance. The cases of hypertrophic pachymeningitis include infections such as tuberculosis, fungal and meningococcal meningitis, and autoimmune diseases such as rheumatoid arthritis, Wegener's granulomatosis, and sarcoidosis. Serologic test results for RA factor were positive in two patients, and no arthritis was found. One patient was diagnosed as meningitis, which was considered to be a field disease. MRI scan revealed marked dural thickening with circumference. It was hypointense on both T1 and T2WI, and contrast enhancement was prominent. All patients were successively cured by steroid therapy. The patients showed initially good response to steroid therapy, but in one patient, symptoms recurred when the steroid dosage was reduced. Laminectomy and markedly thickened dura compression were performed, and the cord was noted. This was partially excised for the purpose of curing and diagnosis. Echo proved useful for the diagnosis of hypertrophic pachymeningitis.

DOI： 10.5035/nishiseisai.54.558

Cement augmentation for avascular necrosis of the femoral head

CHOSA Etsuo

30 48 - 51 2004.10

Language：Japanese Publishing type：Research paper (scientific journal)

P-539 アルブミン分子上におけるサイトII結合阻害薬ナブメトン(レリフェン)と脂肪酸の変化を利用した投与法に関する基礎的検討(10.TDM・投与設計,"薬剤師がつくる薬物治療"-薬・薬・学の連携-)

徳永仁, 高村徳人, 帖佐悦男, 藤田健一, 奥村学, 山崎啓之, 横田崇, 緒方賢次, 日高宗明, 黒木教彰, 甲斐晃弘, 千代反田晋, 中村禎志, 川井恵一, 有森和彦

日本医療薬学会年会講演要旨集 14 2004.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本医療薬学会

P-540 薬物血清蛋白結合変化を敏速に予測するための薬学的分布診断法(動態学的血管内聴診法)の基礎的原理と病態時の診断事例(10.TDM・投与設計,"薬剤師がつくる薬物治療"-薬・薬・学の連携-)

高村徳人, 帖佐悦男, 徳永仁, 藤田健一, 奥村学, 山崎啓之, 緒方賢次, 日高宗明, 黒木教彰, 甲斐晃弘, 千代反田晋, 本屋敏郎, 平井正己, 松岡俊和, 川井恵一, 有森和彦

日本医療薬学会年会講演要旨集 14 2004.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本医療薬学会

圧潰を生じた大腿骨頭壊死に対する新しい骨頭温存手術-セメント充填補強術- Reviewed

帖佐悦男，坂本武郎，渡邊信二，黒沢治，前田和徳，濱田浩朗

Hip Joint ( 30 ) 48 - 51 2004.9

Language：Japanese Publishing type：Research paper (scientific journal)

急速破壊型股関節症の病因検討 Reviewed

前田和徳，帖佐悦男，坂本武郎，渡邊信二，濱田浩朗，黒沢治

Hip Joint ( 30 ) 374 - 377 2004.9

Language：Japanese Publishing type：Research paper (scientific journal)

Hip-spine syndrome X-P像の撮影時の肢位・股関節症の状態による変化 Reviewed

坂本武郎，帖佐悦男，渡邊信二，濱田浩朗，黒沢治，前田和徳

Hip Joint ( 30 ) 305 - 307 2004.9

Language：Japanese Publishing type：Research paper (scientific journal)

年長児ペルテス病に対する大腿骨骨切り術とSalter骨盤骨切り術併用の検討 Reviewed

黒沢治，帖佐悦男，坂本武郎，渡邊信二，濱田浩朗，前田和徳

Hip Joint ( 30 ) 230 - 233 2004.9

Language：Japanese Publishing type：Research paper (scientific journal)

Arthroscopic Subtotal Meniscectomy for Discoid Results in Sports

YAMAMOTO Keitarou

24 ( 1 ) 2004.6

Language：Japanese Publishing type：Research paper (scientific journal)

当科におけるWatson法の短期成績 Reviewed

吉川教恵，帖佐悦男，黒木龍二，矢野浩明，河野立，谷畠満

整形外科と災害外科 53 ( 4 ) 806 - 809 2004.4

Language：Japanese Publishing type：Research paper (scientific journal)

A biomechanical study of lumbar fusion based on a three-dimensional nonlinear finite element method.

Totoribe K, Chosa E, Tajima N

Journal of spinal disorders & techniques 17 ( 2 ) 147 - 53 2004.4

Language：Japanese Publishing type：Research paper (scientific journal)

Analysis of the effect of lumbar spine fusion on the superior adjacent intervertebral disk in the presence of disk degeneration, using the three-dimensional finite element method.

Chosa E, Goto K, Totoribe K, Tajima N

Journal of spinal disorders & techniques 17 ( 2 ) 134 - 9 2004.4

Language：Japanese Publishing type：Research paper (scientific journal)

Posterolateral lumbar fusion Reviewed

Tajima N，Chosa E，Watanabe S

Journal of orthopaedic sience 9 ( 3 ) 327 - 333 2004.3

Language：English Publishing type：Research paper (scientific journal)

３本スパイクセメントレス人工股関節(JOHP)の経験 Reviewed

甲斐糸乃，帖佐悦男，渡邊信二，坂本武郎，福元洋一，濱田浩朗，黒沢治，前田和徳

整形外科と災害外科 53 ( 3 ) 546 - 549 2004.3

Language：Japanese Publishing type：Research paper (scientific journal)

Analysis of the effect of lumbar spine fusion on the superior adjacent intervertebral disk in the presence of disk degeneration， using the three-dimensional finite element method Reviewed

Chosa E，Goto K，Totoribe K，Tajima N

Journal of spinal disorders & techniques 17 ( 2 ) 134 - 139 2004.2

Language：English Publishing type：Research paper (scientific journal)

A biomechanical study of lumbar fusion based on a three-dimensional nonlinear finite element method Reviewed

Totoribe K，Chosa E，Tajima N

Journal of spinal disorders & techniques 17 ( 2 ) 147 - 153 2004.2

Language：English Publishing type：Research paper (scientific journal)

A biomechanical study of lumbar spondylolysis based on a three-dimensional finite-element method Reviewed

Chosa E，Totoribe K，Tajima N

Journal of orthopaedic research 22 ( 1 ) 158 - 163 2004.1

Language：English Publishing type：Research paper (scientific journal)

脊髄損傷患者に対するアンケート調査による社会的不利の検討 Reviewed

鳥取部光司，帖佐悦男，濱田浩朗，久保紳一郎，黒木浩史，渡部正一，田島直也

宮崎県医師会医学会誌 28 ( 1 ) 37 - 40 2004.1

Language：Japanese Publishing type：Research paper (scientific journal)

整形外科手術におけるAcutrak screwの使用経験〜成績不良例の検討〜 Reviewed

山本惠太郎，帖佐悦男，園田典生，黒木龍二，矢野浩明，田島直也

整形外科と災害外科 53 ( 1 ) 199 - 202 2004.1

Language：Japanese Publishing type：Research paper (scientific journal)

RAの臼底突出に対するAcetaburlar reinforcement ring with hook使用例の成績 Reviewed

桐谷力，帖佐悦男，坂本武郎，渡邊信二，黒沢治，内田秀穂，前田和徳，黒木修司，田島直也

整形外科と災害外科 53 ( 1 ) 111 - 115 2004.1

Language：Japanese Publishing type：Research paper (scientific journal)

四肢に多発したSchwannomatosisの症例報告 Reviewed

黒木修司，帖佐悦男，坂本武郎，渡邊信二，黒沢治，内田秀穂

整形外科と災害外科 53 ( 1 ) 71 - 74 2004.1

Language：Japanese Publishing type：Research paper (scientific journal)

A biomechanical study of lumbar spondylolysis based on a three-dimensional finite element method.

Chosa E, Totoribe K, Tajima N

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 22 ( 1 ) 158 - 63 2004.1

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1016/S0736-0266(03)00160-8

Posterolateral lumbar fusion.

Tajima N, Chosa E, Watanabe S

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 9 ( 3 ) 327 - 33 2004

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00776-004-0773-8

Increased plasma and joint tissue adrenomedullin concentrations in patients with rheumatoid arthritis compared to those with osteoarthritis Reviewed

Chosa E, Hamada H, Kitamura K, Eto T, Tajima N

J Rheumatol 30 ( 12 ) 2553 - 2556 2003.12

Language：English Publishing type：Research paper (scientific journal)

Increased plasma and joint tissue adrenomedullin concentrations in patients with rheumatoid arthritis compared to those with osteoarthritis.

Chosa E, Hamada H, Kitamura K, Eto T, Tajima N

The Journal of rheumatology 30 ( 12 ) 2553 - 6 2003.12

Language：Japanese Publishing type：Research paper (scientific journal)

Posterior releasing techniques for idiopathic scoliosis: microscopic discectomy and transverse process resection: a technical note.

Kubo S, Tajima N, Chosa E, Kuroki H, Goto K

Journal of spinal disorders & techniques 16 ( 6 ) 528 - 33 2003.12

Language：Japanese Publishing type：Research paper (scientific journal)

股関節の手術的脱臼法の経験

帖佐悦男，田島直也，坂本武郎，渡邊信二，黒沢　治

Hip Joint 29 232 - 235 2003.9

Language：English Publishing type：Research paper (scientific journal)

TKAにおける骨移植の脛骨コンポーネントの安定性に及ぼす影響　有限要素法を用いて Reviewed

鳥取部光司，帖佐悦男，園田典生，後藤啓輔，田島直也

日本臨床バイオメカ二クス学会誌 ( 24 ) 299 - 303 2003.9

Language：Japanese Publishing type：Research paper (scientific journal)

Anterior acetabular head index of the hip on false-profile views. New index of anterior acetabular cover.

Chosa E, Tajima N

The Journal of bone and joint surgery. British volume 85 ( 6 ) 826 - 9 2003.8

Language：Japanese Publishing type：Research paper (scientific journal)

Anterior acetabular head index of the hip on false-profile views

Chosa E., Tajima N.

Journal of Bone and Joint Surgery - Series B 85 ( 6 ) 826 - 829 2003.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Bone and Joint Surgery - Series B

The vertical-centre-anterior margin (VCA) angle quantifies the anterior cover of the femoral head. However, when the femoral head is deformed it may be difficult to identify its centre. We have therefore created a new index, the anterior acetabular head index (AAHI) which is measured on the false-profile radiograph. We measured the VCA and AAHI angles in 312 hips in which the centre-edge angle was >25°. There were 250 patients, 86 men and 164 women, whose ages ranged from 20 to 65 years. The mean AAHI was 84.1% (81.7% in women and 88.5% in men). There was a correlation between the AAHI and VCA angles. Our data suggest that the AAHI is useful in the evaluation of anterior acetabular cover and that it is higher in men than in women.

Evaluation of human beta-enolase as a serum marker for exercise-induced muscle damage.

Chosa E, Sekimoto T, Sonoda N, Yamamoto K, Matsuda H, Takahama K, Tajima N

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 13 ( 4 ) 209 - 12 2003.7

Language：Japanese Publishing type：Research paper (scientific journal)

Evaluation of human β-enolase as a serum marker for exercise-induced muscle damage

Chosa E., Chosa E., Sekimoto T., Sonoda N., Yamamoto K., Matsuda H., Takahama K., Tajima N.

Clinical Journal of Sport Medicine 13 ( 4 ) 209 - 212 2003.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Clinical Journal of Sport Medicine

Objective: To evaluate whether the serum β-enolase level is a useful indicator of exercise-induced muscle damage in athletes. Design: Blood samples were taken from 49 adult amateur marathon runners before and immediately after a marathon race, and the serum levels of β-enolase and creatine phosphokinase were measured. Setting: The Aoshima Taiheiyo Marathon 2000, Miyazaki, Japan, on a cloudy day in December with an ambient temperature of 18°C. Subjects: Forty-nine adult amateur marathon runners (42 men and 7 women) who regularly participated in runs. Intervention: The intervention was a marathon run. Main Outcome Measures: Serum β-enolase was measured using a sensitive sandwich enzyme-linked immunosorbent assay. Serum creatine phosphokinase was measured using a standard procedure. Results: The mean β-enolase concentration was 9.45 ± 3.11 ng/mL before the race. It increased to 22.11 ± 8.80 ng/mL after the race, representing a proportional increase of 1.57 ± 1.46. The serum concentration of β-enolase after the race was significantly higher than that before the race (P < 0.0001). Moreover, the serum β-enolase level increased as much as the creatine phosphokinase level after the race, and strongly correlated with creatine phosphokinase (r = 0.828, P < 0.0001). The proportional increase of β-enolase also correlated with that of creatine phosphokinase (r = 0.441, P < 0.005). Conclusions: Our data suggest that the absolute values of the serum β-enolase are more appropriate to relate to muscle damage.

DOI： 10.1097/00042752-200307000-00003

Influence of head mass on the acceleration of the head and neck complex in automobile rear-end collisions using a three-dimensional finite element method

Anterior acetabular head index of the hip on false-profile views.New index of anterior acetabular cover Reviewed

Chosa E, Tajima N

J Bone Joint Surg Br 85 ( 6 ) 826 - 829 2003.6

Language：English Publishing type：Research paper (scientific journal)

Posterior releasing techniques for idiopathic scoliosis:microscopic discectomy and transverse process resection :a technical note Reviewed

Kubo S, Tajima N, Chosa E, Kuroki H, Goto K

J Spinal Disord Tech 16 ( 6 ) 528 - 533 2003.6

Language：English Publishing type：Research paper (scientific journal)

Chosa E., Totoribe K., Tajima N.

Journal of Musculoskeletal Research 7 ( 2 ) 151 - 156 2003.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Musculoskeletal Research

This study evaluated the influence of head mass on the acceleration of the head and neck complex in automobile rear-end collisions using a three-dimensional finite element method. The geometry of the finite element model is based on a cervical (C2-7) motion segment of a 20-year-old man that was obtained by computed tomography. Four types of models were prepared by changing the parameters of mass for an examination of the effects of head mass. Simulated loads were applied at the lower end of the C7 vertebra, with the axial direction constrained. Each model was loaded, and the head acceleration and distribution of von Mises stress were analyzed. Stress was observed to concentrate on the C2/3, C5/6 and C6/7 intervertebral discs. With a large head mass, the delay of the initial rise of the acceleration curve was large and the value of acceleration was small. On the contrary, when the head mass was small, the acceleration curve started to rise earlier. The acceleration curve of the model with the head mass of 1.0 kg was the closest to that of the experiments by Severy. Head mass is an important factor which influences the dynamic response of the head in rear-end collisions.

DOI： 10.1142/S0218957703001071

Evaluation of Human bate-Enolase as a Serum Marker for Exercise-induced Muscle Damage Reviewed

Chosa E, Sekimoto T, Sonoda N, Yamamoto K, Matsuda H, Takahama K, Tajima N

Clin J Sport Med 13 ( 4 ) 209 - 2012 2003.4

Language：English Publishing type：Research paper (scientific journal)

Expression of adrenomedullin and its receptor by chondrocyte phenotype cells.

Chosa E, Hamada H, Kitamura K, Kuwasako K, Yanagita T, Eto T, Tajima N

Biochemical and biophysical research communications 303 ( 1 ) 379 - 86 2003.3

Language：Japanese Publishing type：Research paper (scientific journal)

関節リウマチ（RA）患者に対する鎮痛薬ナブメトンの効果的な投与法 Reviewed

高村徳人，帖佐悦男，奥村　学，横田　崇，藤田健一，日高宗明，緒方賢次，山崎啓之，徳永　仁，津田聖一，川井恵一，有森和彦

医薬ジャーナル 39 ( 3 ) 1041 - 1046 2003.3

Language：Japanese Publishing type：Research paper (scientific journal)

宮崎県高校野球選手に対する傷害調査 Reviewed

大倉俊之，園田典生，黒木龍二，矢野浩明，山本惠太郎，帖佐悦男，田島直也

整形外科と災害外科 52 ( 2 ) 287 - 289 2003.2

Language：Japanese Publishing type：Research paper (scientific journal)

Expression of adrenomedullin and its receptor by chondrocyte phenotype cells Reviewed

Chosa E, Hamada H, Kitamura K, Kuwasako K, Yanagita T, Eto T, Tajima N

Biochem Biophys Res Commun 303 ( 1 ) 379 - 386 2003.1

Language：English Publishing type：Research paper (scientific journal)

Biomechanical analysis for stress fractures of the anterior middle third of the tibia in athletes: nonlinear analysis using a three-dimensional finite element method.

Sonoda N, Chosa E, Totoribe K, Tajima N

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 8 ( 4 ) 505 - 13 2003

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00776-003-0671-5

Effects of lumbar spinal fusion on the other lumbar intervertebral levels (three-dimensional finite element analysis).

Goto K, Tajima N, Chosa E, Totoribe K, Kubo S, Kuroki H, Arai T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 8 ( 4 ) 577 - 84 2003

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00776-003-0675-1

Adrenomedullin stimulates the growth of cultured normal human osteoblasts as an autocrine/paracine regulator Reviewed

mada H, Kitamura K, Chosa E, Eto T, Tajima N.

Peptides 23 ( 12 ) 2163 - 2168 2002.12

Language：English Publishing type：Research paper (scientific journal)

Effect of direct angiogenesis inhibition in rheumatoid arthritis using a soluble vascular endothelial growth factor receptor 1 chimeric protein Reviewed

Sekimoto T, Hamada K, Oike Y, Matsuoka T, Matsumoto M, Chosa E, Suda T,Tajima N, Yamamura K

The Journal of Rheumatology ( 29 ) 240 - 245 2002.9

Language：English Publishing type：Research paper (scientific journal)

慢性関節リウマチにおけるsoluble VEGFR1-Fcを用いた血管新生抑制療法の効果 Reviewed

関本朝久，渡部正一，帖佐悦男，谷脇功一，市原正彬，田島直也

リウマチ 42 ( 2 ) 421 - 421 2002.9

Language：Japanese Publishing type：Research paper (scientific journal)

HATCPコーティング人工骨頭の術後５年以上のＸ線学的検討 Reviewed

黒沢　治，帖佐悦男，坂本武郎，渡邊信二，村上恵美，田島直也

整形外科と災害外科 51 ( 1 ) 709 - 712 2002.8

Language：Japanese Publishing type：Research paper (scientific journal)

HATCPコーティング人工骨頭の５年以上の成績について Reviewed

坂本武郎，帖佐悦男，渡邊信二，村上恵美，田島直也

Hip Joint ( 28 ) 388 - 390 2002.8

Language：Japanese Publishing type：Research paper (scientific journal)

医学部ラグビー部員の頚部周囲筋力 Reviewed

田島卓也，田島直也，帖佐悦男，園田典生，山本惠太郎

日本臨床スポーツ医学会誌 10 ( 3 ) 490 - 494 2002.6

Language：Japanese Publishing type：Research paper (scientific journal)

Hydroxyapatite block for use in posterolateral lumbar fusion: a report of four cases.

Totoribe K, Tajima N, Chosa E, Matsumoto M, Kataoka H, Koono M

Clinical orthopaedics and related research ( 399 ) 146 - 51 2002.6

Language：Japanese Publishing type：Research paper (scientific journal)

Hydroxyapatite block for use in posterolateral lumbar fusion: a report of four cases Reviewed

Koji Totoribe, Naoya Tajima, Etsuo Chosa, Masanori Matsumoto, Hiroaki Kataoka, Masashi Koono

Ｃｌｉｎｉｃａｌ Orthopaedics and Related Research ( 399 ) 146 - 151 2002.5

Language：English Publishing type：Research paper (scientific journal)

Mechanical analysis of the lumbar vertebrae in a three-dimensional finite element method model in which intradiscal pressure in the nucleus pulposus was used to establish the model

Keisuke Goto, Naoya Tajima, Etsuo Chosa, Koji Totoribe, Hiroshi Kuroki, Yuichi Arizumi, Takashi Arai

Jounal of Orthopaedic Science 7 ( 2 ) 243 - 246 2002.5

Language：English Publishing type：Research paper (scientific journal)

骨接合術に対するAcutrak screw(ACUMED)の使用経験 Reviewed

山本惠太郎，帖佐悦男，園田典生，黒木龍二，矢野浩明，田島直也

整形外科と災害外科 51 ( 1 ) 189 - 192 2002.4

Language：Japanese Publishing type：Research paper (scientific journal)

Influence of bioresorbable, unsintered hydroxyapatite/poly-L-lactide composite films on spinal cord, nerve roots, and epidural space.

Matsumoto M, Chosa E, Nabeshima K, Shikinami Y, Tajima N

Journal of biomedical materials research 60 ( 1 ) 101 - 9 2002.4

Language：Japanese Publishing type：Research paper (scientific journal)

Influence of bioresorbable, unsintered hydroxyapatite/poly-L-lactide composite films on spinal cord, nerve roots, and epidural space

Matsumoto M., Chosa E., Nabeshima K., Shikinami Y., Tajima N.

Journal of Biomedical Materials Research 60 ( 1 ) 101 - 109 2002.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Biomedical Materials Research

The effect of forged unsintered hydroxyapatite/poly-L-lactide (u-HA/PLLA) composite films on spinal cord and nerve roots and its degradation behavior and osteoconductivity in epidural space were compared with those of calcined HA (c-HA)/PLLA and unfilled PLLA films. Partial laminectomy was performed on 20 rabbits, and u-HA/PLLA and PLLA films were implanted in the intervertebral space. Total laminectomy was performed on 30 rabbits to implant u-HA/PLLA, c-HA/PLLA, and PLLA films in both epidural and subcutaneous spaces. For up to 50 weeks, there were no histological changes in the spinal cord or nerve root, and no inflammatory cell infiltration into the epidural space around the films. The rate of decrease in viscosity average molecular weight of both composite films was initially higher than that of PLLA but eventually became lower, although there was no difference in the degradation behavior of the three films in either the epidural or subcutaneous spaces after 50 weeks. Scanning electron microscopic and energy-dispersive X-ray analysis indicated calcium phosphate deposits on the surface of composite films with new bone formation from 4 weeks. The u-HA/PLLA composite film therefore has good biocompatibility, osteoconductivity, and fast primary degradation rate, which may prove compatible with application to spinal surgery. © 2002 John Wiley & Sons, Inc.

DOI： 10.1002/jbm.1283

Effect of direct angiogenesis inhibition in rheumatoid arthritis using a soluble vascular endothelial growth factor receptor 1 chimeric protein.

Sekimoto T, Hamada K, Oike Y, Matsuoka T, Matsumoto M, Chosa E, Suda T, Tajima N, Yamamura K

The Journal of rheumatology 29 ( 2 ) 240 - 5 2002.2

Language：Japanese Publishing type：Research paper (scientific journal)

Mechanical analysis of the lumbar vertebrae in a three-dimensional finite element method model in which intradiscal pressure in the nucleus pulposus was used to establish the model.

Goto K, Tajima N, Chosa E, Totoribe K, Kuroki H, Arizumi Y, Arai T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 7 ( 2 ) 243 - 6 2002

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1007/s007760200040

Biochemical and morphological changes in herniated human intervertebral disc

AHSAN RASHEDUL, TAJIMA NAOYA, CHOSA ETSUO, SUGAMATA MASAO, SUMIDA MICHIHIRO, HAMADA MINORU

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 6 ( 6 ) 510 - 518 2001.12

Language：Japanese Publishing type：Research paper (scientific journal)

Biochemical and morphological changes in herniated human intervertebral disc

Ahsan R., Tajima N., Chosa E., Sugamata M., Sumida M., Hamada M.

Journal of Orthopaedic Science 6 ( 6 ) 510 - 518 2001.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

The molecular and morphologic features of herniated human intervertebral disc tissues are of particular importance to clarify the pathogenesis. The present study analyzed the biochemical and morphological features of herniated intervertebral disc tissues to determine the constituent factors responsible for intervertebral disc herniation. A total of 32 herniated disc specimens and 4 control disc samples were analyzed. Collagen subunit composition, collagenase activity, lipid peroxidation level, caspase-3 activity, metal levels, morphologic studies, and genetic analysis were performed on herniated disc tissues of chronic (group A) and acute (group B) group and compared with findings of control group. Nick translation analysis in situ revealed apoptotic-positive stained DNA fragments as black-brown spots in herniated disc tissues. The presence of type II collagen in control disc samples and its absence in herniated samples were confirmed immunohistochemically. The increased caspase-3 activity, the apoptotic-positive stained DNA fragments, and the electron microscopic findings suggest enhanced programmed cell death in herniated discs. The significant increase in lipid peroxidation levels and collagenase activity, and the low metal levels suggest the enhancement of cell death signals in herniated discs, caused by oxygen stress. Linkage analysis of herniated disc tissues in Japanese individuals may suggest ethnic variation. These findings may be helpful in understanding the pathogenesis of herniated disc disease.

DOI： 10.1007/s007760100006

Biomechanical analysis of effects of foot placement with varying chair height on the motion of standing up

Kawagoe S., Tajima N., Chosa E.

Journal of Orthopaedic Science 5 ( 2 ) 124 - 133 2000.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

Individual experience reveals that posterior foot placement enables one to stand up easily from a chair. However, the way in which foot placement affects this motion has not been investigated in detail. This study was performed to examine the effects of foot placement in the initial stage of the dynamics of standing up from a chair. Subjects wearing light-emitting diode markers and surface electrodes stood up from a chair over force plates, and ground reaction force, joint angle, and muscle activity were measured. The motions required to stand up from chairs 30, 40, or 50 cm in height were analyzed with anterior, vertical, and posterior foot placement. With anterior foot placement, the forward-acceleration components of the ground reaction force were recorded with simultaneous and long-sustained activity of the muscles in order to shift the center of gravity of the body forward even more after lift-off. Our findings indicate that the distance between the center of gravity and the point of application of ground reaction force at lift-off are critical factors in the standing-up motion, and that chairs should be of adequate height as well as having sufficient space under the seat to permit the backward movement of the lower legs.

Thoracic microdiscectomy and arthrolysis of costotransverse joint as a means of releasing technique for idiopathic scoliosis

Kubo S., Tajima N., Chosa E., Goto K.

Studies in Health Technology and Informatics 59 285 - 288 1999.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Studies in Health Technology and Informatics

The purpose of this study is to evaluate the effects of thoracic microdiscectomy(anterior release) and arthrolysis of costotransverse joint(partial resection of transverse process) as additional technique in posterior procedure for scoliosis. Subjects consisted of 11 idiopathic scoliosis patients (1 male and 10 females) aged 12 to 17 years(average:15.3), operated posteriorly using CD technique. The subjects were divided into 3 groups ; group A: three patients operated without release, group B: four patients with arthrolysis of costotransverse joint, group C ; four patients with microdiscectomy of three discs around the apical vertebra and arthrolysis of costotransverse joint, the average preoperative Cobb angle were, respectively, 56, 52 and 55 degrees. Cobb angle and disc wedge angle were measured. The correction rates of Cobb angle in the group A,B and C were 77%, 65%, and 53%, respectively. Improvement in the disc wedge angle was obtained especially in-group A. Microdiscectomy appeared to be effective to de-stabilize the thoracic curve. This additional technique provide excellent correction in one stage posterior procedure. Concerning to the arthrolysis of the costotransverse joint,more detailed study and biomechanical examination are needed for accurate evaluation.

DOI： 10.3233/978-1-60750-903-5-285

A biomechanical study of posterolateral lumbar fusion using a three- dimensional nonlinear finite element method

Totoribe K., Tajima N., Chosa E.

Journal of Orthopaedic Science 4 ( 2 ) 115 - 126 1999.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

Biomechanical analyses under compressive load, flexion, and extension torque were performed, using a nonlinear three-dimensional finite element method, to evaluate stability in posterolateral fusion. Effects of facet fusion and disc denucleation on posterolateral fusion were also examined. Using an initially prepared L4-5 motion segment model, we prepared a denucleation model, posterolateral fusion models classified by presence or absence of denucleation and facet fusion, and an interbody fusion model. In the denucleation model, rigidity was less than in the normal model, and maximum rigidity was analyzed for the interbody fusion model. The effect of denucleation on posterolateral fusion was also analyzed. Taking into account the instability of the anterior elements, including the intervertebral disc, appears to be clinically important. In the posterolateral fusion model under compressive load, the axis of rotation moved principally toward the fusion mass, and axial displacement and flexion rotation were induced. Sagittal rotation angles under flexion and extension torque were 1.5°-2.3°at a maximum moment of 15N-m, demonstrating elasticity of posterolateral fusion. When combined with facet fusion, posterolateral fusion yielded increase of load transfer across the lamina and decrease of rotation angle of about 10% under flexion-extension torque. Adjunctive clinical use of facet fusion should permit more solid posterolateral fusion.

DOI： 10.1007/s007760050083

Segmental square spinal instrumentation for posterior lumbar spinal fixation

Tajima N., Tajima N., Chosa E., Kubo S., Kuroki H., Matsumoto M.

Journal of Spinal Disorders 12 ( 3 ) 240 - 244 1999.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Spinal Disorders

The purpose of this study is to evaluate the clinical results of operations using a new spinal instrumentation for posterior fixation, called segmental square spinal (3-S) instrumentation. The 3-S instrument consists of two pairs of hooks to clasp the interarticular portion of the lamina bilaterally, two horizontal bars to connect the hooks on the fight and left, and rods to connect the hooks side by side on the top and bottom. Twenty- seven patients who had degenerative lumbar disorders underwent operations with the 3-S instrument. Rigid fixation was obtained in all cases immediately after the operation. Bone union rates were 91% (21/23) with posterolateral fusion. The 3-S instrument seems to be suitable for spinal disorders in which anterior spinal fusion is not necessary, especially for degenerative spinal disorders.

A cement spacer for two-stage revision of infected implants of the hip joint

Leunig M., Leunig M., Chosa E., Speck M., Ganz R.

International Orthopaedics 22 ( 4 ) 209 - 214 1998.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：International Orthopaedics

We report the technical details and clinical results of twelve patients who had deep infections of implants in the hip joint and were treated by two-stage revision, using a gentamicin-loaded, hand-moulded cement spacer inserted for the period between resection and reimplantation arthroplasty. During management with the spacer, usually for 4 months, patients were almost free of pain and mobile with good leg control, spending 2/3 of the treatment period at home. Six of twelve spacers failed locally due to dislocation [5] or cement fracture [1], and more than two further episodes of surgery were required in 3 patients. Problems with dislocation of the spacer were significantly higher when the head to neck offset was lacking (P < 0.05) or when anchorage in the femoral shaft was poor. Nevertheless, infection after reimplantation arthroplasty did not occur by the time of follow-up (2.2 years). Based on these data, we consider that the use of the cement spacer is a promising approach to the treatment of complicated infections of the hip joint.

DOI： 10.1007/s002640050244

Posterolateral lumbar fusion - Biomechanical study and clinical results

Tajima N., Chosa E., Totoribe K., Kubo S., Kuroki H.

Journal of Musculoskeletal Research 2 ( 2 ) 101 - 107 1998.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Musculoskeletal Research

This paper discusses the biomechanics and long-term results of posterolateral (PL) lumbar fusion for degenerative lumbar spinal diseases. In the biomechanical study, the geometry of the finite element model is based on the L4-5 motion segment. The disc degeneration model was simulated by changing the interbody material properties. The behavior of the PL fusion model and the effects of the anterior elements on PL lumbar fusion were studied in compression, flexion, and extension. In the clinical study, 40 patients with a mean age of 39 years (19 to 63) were treated with PL fusion and the mean follow-up period was 14 years. Clinical evaluation was made by the Japanese Orthopaedic Association (J.O.A.) score. Fusion success was determined by X-ray radiographs. Stress distribution results indicate that there were high stresses in the upper part of the grafted bone for PL fusion. The axial displacement of the L4 vertebral body and the stress of the grafted bone for PL fusion increased in the disc degeneration model. In flexion, the extension load stress concentrated on the L4 side of PL fusion model between transverse processes. Clinically, the J.O.A. score improved by 24 points postoperatively. Radiographically, the success rate of the fusion was 93%. The long-term results were so good that this technique can be recommended. It is suggested that the instability including the degree of disc degeneration is one of the important factors in PL lumbar fusion. © World Scientific Publishing Company.

Cement Spacer Technique in 2-stage Revision for Infected Hip Implants

CHOSA E., LEUNIG M, GANZ R

72 ( 2 ) 1998.2

Language：Japanese Publishing type：Research paper (scientific journal)

Biomechanical study of the lumbar spondylolysis using a three-dimensional finite element model and 3D-CT images

Tajima N., Totoribe K., Chosa E.

Studies in Health Technology and Informatics 37 185 - 188 1997.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Studies in Health Technology and Informatics

Biomechanical characteristics of the interarticular portion of the lumbar vertebra were investigated using a three-dimensional finite element method. Stress distribution results indicate that there were high stresses in the pars interarticularis, especially the ventral cortical bone of it, and the anterior shear force had an increasing effect on the magnitude of the stress in the pars interarticularis. 3D-CT is helpful in understanding the complex anatomy such as the spine. The results of finite-element studies and 3D-CT were in good agreement with each other. It is suggested that the stress on the interarticular portion of lumbar vertebra is an important factor in the etiology of spondylolysis.

DOI： 10.3233/978-1-60750-881-6-185