Papers - TAKEDA Ryuichiro
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Intrastriatal grafts of fetal ventral mesencephalon improve allodynia-like withdrawal response to mechanical stimulation in a rat model of Parkinson's disease. Reviewed
Takeda R, Ishida Y, Ebihara K, Abe H, Matsuo H, Ikeda T, Koganemaru G, Kuramashi A, Funahashi H, Magata Y, Kawai K, Nishimori T
Neurosci. Lett. 2014.6
Language：English Publishing type：Research paper (scientific journal)
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Changes in dopamine D2 receptors and 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine uptake in the brain of 6-hydroxydopamine-lesioned rats Reviewed
石田 康,川井 恵一,間賀田 泰寛,武田 龍一郎,橋口 浩志,安部 博史,Takahiro Mukai,佐治 英郎
Neurodegenerative Diseases 1 ( 2月3日 ) 109 - 112
Language：English Publishing type：Research paper (scientific journal)
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職場におけるメンタルヘルス対策～労働安全衛生法改正に伴うストレスチェックの導入～ Invited
武田龍一郎
CNSフロンティア 2014.7
Language：Japanese Publishing type：Research paper (other academic)
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ストレス負荷時の視床下部室傍核・内側前頭前野における一酸化窒素動態と機能の解析 Reviewed
石塚 雄太,石田 康,橋口 浩志,武田 龍一郎,中原 大一郎,西森 利數,河南 洋
精神薬療研究年報 36 196 - 202
Language：Japanese Publishing type：Research paper (scientific journal)
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The role of spinal serotonin receptor and alpha adrenoceptor on the antiallodynic effects induced by intrathecal milnacipran in chronic constriction injury rats. Reviewed
Nakamura T, Ikeda T, Takeda R, Igawa K, Naono-Nakayama R, Sakoda S, Nishimori T, Ishida Y
Eur J Pharmacol 2014.5
Language：English Publishing type：Research paper (scientific journal)
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Analgesic effect of milnacipran is associated with c-Fos expression in the anterior cingulate cortex in the rat neuropathic pain model （共著） Reviewed
Ryuichiro Takeda a,Yuko Watanabe, Tetsuya Ikeda, Hiroshi Abe, Kosuke Ebihara, Hisae Matsuo, Hiroi Nonaka, Hiroyuki Hashiguchi, Toshikazu Nishimori, Yasushi Ishida
Neuroscience research 64 380 - 384 2009.4
Language：English Publishing type：Research paper (scientific journal)
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Alteration of striatal [11C]raclopride and 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine uptake precedes development of methamphetamine-induced rotation following unilateral 6-hydroxydopamine lesions of medial forebrain bundle in rats.
石田 康,川井 恵一,間賀田 泰寛,安部 博史, ,武田 龍一郎,橋口 浩志, ,佐治 英郎
Neurosci. Lett. 389 ( 1 ) 30 - 34
Language：English Publishing type：Research paper (scientific journal)
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Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease. Reviewed
Ebihara K, Ishida Y, Takeda R, Abe H, Matsuo H, Kawai K, Magata Y, Nishimori T
Neurosci Lett 2011.6
Language：English Publishing type：Research paper (scientific journal)
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Unilateral lesions of mesostriatal dopaminergic pathway alters the withdrawal response of the rat hindpaw to mechanical stimulation.
武田 龍一郎,池田 哲也,津田 文子,安部 博史,橋口 浩志,石田 康,西森 利數
Neurosci. Res. 52 ( 1 ) 31 - 36
Language：English Publishing type：Research paper (scientific journal)
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Temperament and Character Inventory (TCI)を用いたうつ病・慢性疼痛併存患者におけるパーソナリティプロフィ－ルの検討 Reviewed
赤瀬川豊，武田龍一郎，長友慶子，船橋英樹，蛯原功介，松尾寿栄，安部博史，有森和彦，石田康
精神医学 2013.7
Language：Japanese Publishing type：Research paper (scientific journal)
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大規模災害発生時の精神保健医療活動にかかわる情報伝達・共有システムの構築 Reviewed
安部博史，武田龍一郎，松尾寿栄，長友慶子，河野次郎，渡路子，石田康
臨床精神医学 2012.9
Language：Japanese Publishing type：Research paper (scientific journal)
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Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain. （共著） Reviewed
Ikeda T, Ishida Y, Naono R, Takeda R, Abe H, Nakamura T, Nishimori T.
Neuroscience Research 63 42 - 46 2009.1
Language：English Publishing type：Research paper (scientific journal)
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Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats Reviewed
Kuramashi A, Abe H, Koganemaru G, Matsuo H, Ikeda T, Ebihara K, Funahashi H, Takeda R, Nishimori T, Ishida Y
Neurosci Lett 2013.8
Language：English Publishing type：Research paper (scientific journal)
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Lamotrigine併用で，陰性症状や不安抑うつ症状が改善した統合失調症と統合失調感情障害の4症例 Reviewed
木村佳代，武田龍一郎，直野慶子，牧田昌平，室井千代，湯地博幸，倉山茂樹，石田康
最新精神医学 2013.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Naono-Nagatomo K., Naono H., Abe H., Takeda R., Funahashi H., Uchimura D., Ishida Y.
Asian Journal of Psychiatry 25 36 - 41 2017.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asian Journal of Psychiatry
© 2016 Elsevier B.V. Aim Aripiprazole (ARP) is a popular antipsychotic drug that has demonstrated ameliorative effects on hyperprolactinemia. However, no study to date has studied the utility of ARP in patients with a long history of schizophrenia and antipsychotic treatment. We therefore examined the effect of partial antipsychotic regimen replacement with ARP on hyperprolactinemia induced by chronic antipsychotic use in patients with schizophrenia. Methods Sixteen patients with a schizophrenia diagnosis (F2) based on the International Classification of Diseases (version 10) were recruited. At months 0, 1, 3, and 6 of the study, serum prolactin, body weight, and blood glucose were measured, and QOL and psychotic symptoms were assessed using Global Assessment of Functioning scores and Clinical Global Impressions of Improvement (CGI-I) scores. Results Nine patients with an average age of 46.7 ± 9.6 years and mean disease duration of 15.9 ± 10.4 years were included in the final analysis. Serum prolactin levels significantly decreased and GAF and CGI-I scores improved significantly over the 6-month period after partial replacement with ARP. Additionally, no changes were observed in body weight or blood glucose over the 6- month period. Conclusion Partial antipsychotic regimen replacement with ARP improves hyperprolactinemia, and may improve the QOL of patients with a long history of schizophrenia. Clinical trial registration number Japan Medical Association, Center for clinical trials D: JMA-IIA00245.
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Burnout in Japanese residents and its associations with temperament and character
Miyoshi R., Matsuo H., Takeda R., Komatsu H., Abe H., Ishida Y.
Asian Journal of Psychiatry 24 5 - 9 2016.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asian Journal of Psychiatry
© 2016 Elsevier B.V. Aim High risk of burnout in healthcare workers has long been recognized. However, there are no methods to predict vulnerability to burnout. Methods We examined whether temperament and character are associated with burnout and depressive state in residents by using the Temperament and Character Inventory (TCI). The TCI was used for residents at the beginning of clinical training and then the Maslach Burnout Inventory–General Survey (MBI–GS) and the Self-Rating Depression Scale (SDS) were administered at the beginning of clinical training and after four and ten months. Participants were 85 residents who started clinical training after graduating from the University of Miyazaki Hospital in April 2012 and 2013. Results After ten months, 23.5% of participants were newly identified with burnout using the MBI-GS and 15.3% of participants were newly diagnosed with depressive state using the SDS. We found that residents with high Cooperativeness were significantly more prone to burnout and that residents with high Harm Avoidance and low Self-Directedness were significantly more prone to depressive states. Conclusions Our results suggest that the TCI can predict not only the risk for future depressive state but also the risk for future burnout. We feel it is important for the resident education system to identify residents with these temperament and character traits and to help high-risk residents avoid burnout and depressive state.
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熊本地震における宮崎県DPATの役割 災害時の支援者支援 Reviewed
松尾寿栄，三好良英，宮原裕，武田龍一郎，松田裕，高野吉輝，益留真由美，石田康
宮崎県医師会医学雑誌 40 ( 2 ) 185 - 191 2016
Language：Japanese Publishing type：Research paper (scientific journal)
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スボレキサントの使用経験 ―睡眠薬の単剤化を試みて― Reviewed
直野久雄，橋口浩志，河野次郎，直野慶子，武田龍一郎，石田康
最新精神医学 21 ( 5 ) 391 - 397 2016
Language：Japanese Publishing type：Research paper (scientific journal)
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インターフェロンによる精神症状発現の予測：気質・性格特性の関与 Reviewed
直野慶子，安部博史，武田龍一郎，岩切久芳，蓮池悟，永田賢治，下田和哉，石田康
精神医学 2015.6
Language：Japanese Publishing type：Research paper (scientific journal)
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宮崎大学医学部附属病院精神科におけるコンサルテーション・リエゾン精神医療の現状（第２報） Reviewed
塚本彩香，直野慶子，武田龍一郎，船橋英樹，宇田川充隆，三好良英，松尾寿栄，安部博史，石田康
宮崎県医師会医学会誌 2015.1
Language：Japanese Publishing type：Research paper (scientific journal)
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Risperidoneからpaliperidoneへ切替え後，糖尿病が増悪した統合失調症の1症例 Reviewed
木村 佳代，武田龍一郎，橘宣祥，倉山茂樹，石田康
精神医学 2014.7
Language：Japanese Publishing type：Research paper (scientific journal)
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Usher症候群患者の精神病症状にaripiprazoleが奏功した一例 Reviewed
倉増伸二，武田龍一郎，大塚和之，石田康
最新精神医学 2014.6
Language：Japanese Publishing type：Research paper (scientific journal)
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オランザピン速効型筋注製剤の投与後に拒薬が改善した統合失調症急性期の２症例 Reviewed
直野久雄，直野慶子，橋口浩志，船橋英樹，武田龍一郎，石田康
精神科 2014.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Blonanserin投与後の統合失調症患者の臨床症状および主観的評価の変化―Blonanserin非投与群を対象とした検討― Reviewed
直野慶子，直野久雄，安部博史，武田龍一郎，牧田昌平，船橋英樹，松尾寿栄，内村大介，石田康
精神科 2014.5
Language：Japanese Publishing type：Research paper (scientific journal)
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松田裕，宇田川充隆，武田龍一郎，橋口浩志，石田康：小児期の広汎性発達障害の興奮性に対し，アリピプラゾールが奏効した3症例 Reviewed
松田裕，宇田川充隆，武田龍一郎，橋口浩志，石田康
松田裕，宇田川充隆，武田龍一郎，橋口浩志，石田康 2014.2
Language：Japanese Publishing type：Research paper (scientific journal)
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三好良英,松尾寿栄,武田龍一郎,小松弘幸,岡山昭彦,石田康：卒後臨床研修期間中のバーンアウトや抑うつに関連する研修医の性格傾向についての前方視的研究（第一報） Reviewed
三好良英,松尾寿栄,武田龍一郎,小松弘幸,岡山昭彦,石田康
臨床精神医学 2013.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Kuramashi A., Abe H., Koganemaru G., Matsuo H., Ikeda T., Ebihara K., Funahashi H., Takeda R., Nishimori T., Ishida Y.
Neuroscience Letters 549 97 - 102 2013.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neuroscience Letters
To clarify the psychopharmacological profile of blonanserin, a novel antipsychotic, we examined its effect on the methamphetamine-induced disruption of latent inhibition (LI) and the neural activation related to this effect in rats. To evaluate the LI, we used a conditioned emotional response in which a tone (conditioned stimulus) was paired with a mild foot shock (unconditioned stimulus). This paradigm was presented to rats licking water. Methamphetamine-induced (1.0. mg/kg, i.p.) disruption of LI was significantly improved by the administration of a higher dose (3.0. mg/kg, i.p.) of blonanserin and tended to be improved by 1 .0-mg/kg blonanserin and 0.2-mg/kg haloperidol but not by a lower dose (0.3. mg/kg) of blonanserin. Immunohistochemical examination showed blonanserin (3.0. mg/kg, i.p.) increased c-Fos expression in the shell area but not in the core area of the nucleus accumbens while methamphetamine (3.0. mg/kg, i.p.) produced the opposite expression pattern. Blonanserin also increased the number of c-Fos expressions in the central amygdala nucleus but not in the basolateral amygdala nucleus or the prefrontal cortex. Blonanserin ameliorates the methamphetamine-induced disruption of LI, as other antipsychotics do, and a neuronal activation and/or modulation of neurotransmission in the nucleus accumbens is related to the disruption of LI by methamphetamine and to its amelioration by blonanserin. © 2013 Elsevier Ireland Ltd.
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東日本大震災に伴う精神疾患の発症・症状増悪 被災遠隔地における実態調査 Reviewed
長友慶子，直野久雄，武田龍一郎，船橋英樹，松尾寿栄，安部博史，牧田昌平，河野次郎，内村大介，倉山茂樹，高宮眞樹，石田康
臨床精神医学 2012.9
Language：Japanese Publishing type：Research paper (scientific journal)
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統合失調症の多飲症に対してquetiapineが奏効した2症例 Reviewed
長友 慶子，武田龍一郎，牧田 昌平，木村 佳代，湯地 博幸，米良 誠剛，倉山 茂樹，石田 康
精神医学 2012.5
Language：Japanese Publishing type：Research paper (scientific journal)
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アリピプラゾールおよび抑肝散が攻撃性等の精神症状に奏功したミトコンドリア病疑いの１症例 Reviewed
倉増伸二，武田龍一郎，河野尚子，塩見一剛，石田康
精神科 2012.3
Language：Japanese Publishing type：Research paper (scientific journal)
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シロスタゾールによって誤嚥性肺炎の頻度が減少した慢性期の脳梗塞の4症例
船橋 英樹, 武田 龍一郎, 松尾 寿栄, 塩入 重正, 荒木 竜二, 尾薗 和彦, 谷口 浩, 三山 吉夫, 石田 康
九州神経精神医学 58 ( 1 ) 14 - 21 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Association of Kyushu Neuropsychiatry
慢性期の脳梗塞を有する入院患者4症例において，シロスタゾール100mg/日の投与を行った。いずれの症例も誤嚥性肺炎の頻度は減少し，有害事象は認めなかった。誤嚥性肺炎の予防にはリハビリテーションなどに加えて，シロスタゾールの少量投与が有用であることが示唆された。
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Effect of aripiprazole on methamphetamine-induced disruption of latent inhibition in rats. Reviewed
Matsuo H, Abe H, Ikeda T, Ebihara K, Takeda R, Nishimori T, Ishida Y
J Behav Brain Sci 2011.8
Language：English Publishing type：Research paper (scientific journal)
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Ebihara K., Ishida Y., Takeda R., Abe H., Matsuo H., Kawai K., Magata Y., Nishimori T.
Neuroscience Letters 496 ( 2 ) 90 - 94 2011.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neuroscience Letters
A study was carried out to examine the effects of acute and chronic l-DOPA treatment on the distribution of the immediate-early gene (IEG) proteins (FosB, c-Fos, and Zif268) in forebrain regions in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease. During a course of chronic l-DOPA treatment (15. mg/day, 15 days), rats with a 6-OHDA lesion developed abnormal involuntary movements. Compared with the rats in the acute l-DOPA treatment group, those in the chronic treatment group had significantly more FosB-immunopositive cells in the anterior cingulate (Cg) and the dorsolateral caudate-putamen ipsilateral to the lesion and significantly fewer c-Fos-immunopositive cells in the Cg, the nucleus accumbens shell, and the basolateral nucleus of amygdala ipsilateral to the lesion. No significant difference was observed in the number of Zif268-immunopositive cells between the acute and chronic l-DOPA groups. In summary, differential expression of three IEG proteins was observed in the forebrain regions during a course of chronic l-DOPA treatment of 6-OHDA-treated hemiparkinsonian rats. © 2011 Elsevier Ireland Ltd.
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Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease Reviewed
Ebihara K, Ishida Y, Takeda R, Abe H, Matsuo H, Kawai K, Magata Y, Nishimori T.
Neuroscience Letters 496 90 - 94 2011.4
Language：English Publishing type：Research paper (scientific journal)
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Perospironeへの切り替えが統合失調症の精神症状，心理社会的機能，錐体外路症状を改善する：22例の後方視的検討． Reviewed
安部博史，長友慶子，安藤一博，橋口浩志，槙英俊，船橋英樹，武田龍一郎，松尾寿栄，石田康
精神科 2011.4
Language：Japanese Publishing type：Research paper (scientific journal)
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新燃岳噴火の精神疾患への影響＊被災2ケ月時点における精神科診療現場からの報告 Reviewed
長友慶子，直野久雄，船橋英樹，倉増亜紀，石田裕一郎，武田龍一郎，石塚雄太，内村大介，石田康
最新精神医学 2011.4
Language：Japanese Publishing type：Research paper (scientific journal)
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石田 康, 武田 龍一郎, 船橋 英樹
精神神經學雜誌 = Psychiatria et neurologia Japonica 112 ( 6 ) 622 - 624 2010.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本精神神経学会
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潜在性肝性脳症の1例 Reviewed
松尾寿栄,武田龍一郎,船橋英樹,楠元寿典,山賀昌治,石田康
精神科 16 87 - 92 2010.1
Language：Japanese Publishing type：Research paper (scientific journal)
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虚偽性障害の妊婦の1症例
船橋英樹，松尾寿栄，長友慶子，武田龍一郎，瀬戸雄飛，山田直史，山内憲之，木許恭宏，石田康
宮崎県医師会医学会誌 34 67 - 71 2010.1
Language：Japanese Publishing type：Research paper (scientific journal)
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診療の風景 曖昧な宮崎 Invited Reviewed
武田龍一郎
九州神経精神医学 55 189 - 192 2009.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Takeda R., Watanabe Y., Ikeda T., Abe H., Ebihara K., Matsuo H., Nonaka H., Hashiguchi H., Nishimori T., Ishida Y.
Neuroscience Research 64 ( 4 ) 380 - 384 2009.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neuroscience Research
The objective of the present study was to examine whether milnacipran, a serotonin-noradrenaline reuptake inhibitor, has an analgesic effect in rats with neuropathic pain. In addition, the c-Fos expression was investigated in the supraspinal sites of the brain and in the spinal dorsal horn in association with the nociceptive processing in rats with neuropathic pain produced by chronic constriction injury (CCI) in the sciatic nerve. In the CCI-induced neuropathic rats, behavioral testing for determining the change in the withdrawal threshold to mechanical stimulation and immunohistochemical detection of c-Fos were both performed. The anti-allodynic effect derived from milnacipran gradually increased over the observation period, indicating that the delayed-onset analgesia might be elicited by the continuous administration of milnacipran. The increased level of c-Fos expression in the anterior cingulate cortex (ACC) induced by noxious mechanical stimulation was significantly inhibited by the continuous administration of milnacipran, indicating that milnacipran might cause a functional modification in the nociceptive processing in the ACC. © 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society.
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IKEDA Tetsuya, ISHIDA Yasushi, NAONO Rumi, TAKEDA Ryuichiro, ABE Hiroshi, NAKAMURA Tadashi, NISHIMORI Toshikazu
Neuroscience research : the official journal of the Japan Neuroscience Society 63 ( 1 ) 42 - 46 2009.1
Language：Japanese Publishing type：Research paper (scientific journal)
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当院における修正型電気けいれん療法の現状
牧田昌平,船橋英樹,長友慶子,武田龍一郎,松尾寿栄,野中博意,植田勇人,石田康
宮崎県医師会医学会誌 33 14 - 18 2009.1
Language：Japanese Publishing type：Research paper (scientific journal)
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Ikeda T., Ishida Y., Naono R., Takeda R., Abe H., Nakamura T., Nishimori T.
Neuroscience Research 63 ( 1 ) 42 - 46 2009.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neuroscience Research
Antidepressants, especially tricyclic antidepressants (TCAs) are widely used for the treatment of various types of chronic and neuropathic pain. The antinociceptive effects of TCAs are, however, complicated. Therefore, two kinds of newer antidepressants whose functions have been more fully clarified were selected, milnacipran, a serotonin and noradrenaline reuptake inhibitor (SNRI) and paroxetine and fluvoxamine, which are selective serotonin reuptake inhibitors (SSRIs). The antiallodynic effects of intrathecal administration of these newer antidepressants were examined in two rat models of neuropathic pain, chronic constriction injury (CCI) of the sciatic nerve and streptozotocin (STZ)-induced diabetic neuropathy. The antiallodynic effect of these antidepressants was evaluated using the von Frey test. The intrathecal administration of milnacipran had an antiallodynic effect in both CCI and STZ-induced diabetic rats in a dose-dependent manner. On the other hand, the intrathecal administration of either paroxetine or fluvoxamine elicited little antiallodynic effect in CCI rats, while both SSRIs had antiallodynic effects in the STZ-induced diabetic rats in a dose-dependent manner. These results indicate a considerable difference to exist in the development and/or maintenance between these two animal models of neuropathic pain and suggest that each of these three antidepressants may be effective for the treatment of diabetic neuropathic pain. © 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society.
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Differential expression of Fos and Zif268 in the nigrostriatal system after methamphetamine administration in a rat model of Parkinson’s disease.（共著 Reviewed
「Ishida Y」「Kawai K」「Magata Y」「Ebihara K」「Takeda R」「Abe H」「Yoshimoto M」「Hashiguchi H」「Odagiri K」「Matsuo H」and 「Nishimori T」
Synapse ６２ ９２０ - ９２６ 2008.12
Language：English Publishing type：Research paper (scientific journal)
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Ishida Y., Kawai K., Magata Y., Ebihara K., Takeda R., Abe H., Yoshimoto M., Hashiguchi H., Odagiri K., Matsuo H., Nishimori T.
Synapse 62 ( 12 ) 920 - 926 2008.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Synapse
The goal of this study was to examine the topological specificity of methamphetamine-induced activation of the immediate-early gene proteins, Fos and Zif268, in the nigrostriatal system in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease with or without intrastriatal grafts of fetal ventral mesencephalon. Methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI) dominantly in the striatum and the globus pallidus (GP) on the intact side as well as in the substantia nigra pars reticulata (SNr) on the lesioned side in the 6-OHDA rats. Lower levels of methamphetamine-induced FLI in the striatum and GP on the lesioned side were restored by intrastriatal grafts which could completely suppress the methamphetamine-induced rotation. In the striatum, a similar tendency could be observed between Fos and Zif268 immunoreactivity following methamphetamine. However, sparse immunoreactivity of Zif268 could be detected in the GP and SNr on both sides in the 6-OHDA rats. Intrastriatal grafts had little influence on Zif268 expression in these two regions. The differential expression of Fos and Zif268 was observed among the three regions of the nigrostriatal system following methamphetamine in the 6-OHDA rats. This may suggest that Fos and Zif268 therefore possess gene-specific and region-specific functions in the basal ganglia nuclei. © 2008 Wiley-Liss, Inc.
DOI： 10.1002/syn.20558
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Psychological prenatal stress reduced the number of BrdU immunopositive cells in the dorsal hippocampus without affecting the open field behavior of male and female rats at one month of age. （共著） Reviewed
「Odagiri K」「Abe H」「Kawagoe C」「Takeda R」「Ikeda T」「Matsuo H」「Nonaka H」「Ebihara K」「Nishimori T」「Ishizuka Y」「Hashiguchi H」「Ishida Y」
Neuroscience Letters 2008.11
Language：English Publishing type：Research paper (scientific journal)
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Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain.
Ikeda T, Ishida Y, Naono R, Takeda R, Abe H, Nakamura T, Nishimori T.
Neuroscience research 2008.10
Language：English Publishing type：Research paper (scientific journal)
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Prenatal psychological stress causes higher emotionality, depression-like behavior, and elevated activity in the hypothalamo-pituitary-adrenal axis. Reviewed
Abe H, Hidaka N, Kawagoe C, Odagiri K, Watanabe Y, Ikeda T, Ishizuka Y, Hashiguchi H, Takeda R, Nishimori T, Ishida Y.
Neuroscience Research 59 145 - 151 2007.6
Language：English Publishing type：Research paper (scientific journal)
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執拗な身体的愁訴に対してフルボキサミンが著効した高齢者の４症例 Reviewed
船橋英樹, 武田龍一郎,松尾寿栄,安部博史,尾薗和彦,谷口浩,三山吉夫,石田康
精神科 11 ( 3 ) 260 - 266 2007.3
Language：Japanese Publishing type：Research paper (scientific journal)
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疼痛治療における抗うつ薬の役割
石田 康，武田龍一郎，安部博史，松尾寿栄，池田哲也，西森利數
臨床と研究 84(2)：99-101（2007） 84 ( 2 ) 99 - 101 2007.2
Language：English Publishing type：Research paper (scientific journal)
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器質性感情障害に対するバルプロ酸ナトリウムの使用経験 Reviewed
鶴衛 亜里砂，植田 勇人，武田 龍一郎，山崎 啓之，児玉 裕文，有森 和彦，石田 康
九州神経精神医学 51 122 - 125 2005.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Ishida Y., Kawai K., Magata Y., Abe H., Yoshimoto M., Takeda R., Hashiguchi H., Mukai T., Saji H.
Neuroscience Letters 389 ( 1 ) 30 - 34 2005.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neuroscience Letters
We studied the positron emission tomography (PET) tracer distributions of ligands for dopamine D 1 receptors ([ 11 C]SCH23390) and D 2 receptors ([ 11 C]raclopride) and of the dopamine precursor analog 6-[ 18 F]fluoro-l-3,4-dihydroxyphenylalanine ([ 18 F]FDOPA) in the brain after 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle in rats. The number of methamphetamine-induced rotation was higher at 14 days than at 3 days after the 6-OHDA lesions. The brains of 6-OHDA-treated rats were analyzed by tissue dissection following i.v. bolus of each tracer at 3 days (acute stage) or 3 weeks (chronic stage) postlesion. [ 11 C]Raclopride, but not [ 11 C]SCH23390, showed higher accumulation in the striatum on the lesion side than on the non-lesion (intact) side both at 3 days and 3 weeks postlesion. On the other hand, lower accumulation of [ 18 F]FDOPA was observed in the striatum on the lesion side at 3 days postlesion and in both the striatum and cerebral cortex on the lesion side at 3 weeks postlesion. Our studies demonstrate that an increase in [ 11 C]raclopride and a decrease in [ 18 F]FDOPA uptake in the denervated striatum is evident even at 3 days after the 6-OHDA lesions when the methamphetamine-induced rotational behavior is not established. © 2005 Elsevier Ireland Ltd. All rights reserved.
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TAKEDA Ryuichiro, IKEDA Tetsuya, TSUDA Fumiko, ABE Hiroshi, HASHIGUCHI Hiroyuki, ISHIDA Yasushi, NISHIMORI Toshikazu
Neuroscience research : the official journal of the Japan Neuroscience Society 52 ( 1 ) 31 - 36 2005.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Ishida Y., Kawai K., Magata Y., Takeda R., Hashiguchi H., Abe H., Mukai T., Saji H.
Neurodegenerative Diseases 1 ( 2-3 ) 109 - 112 2004.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neurodegenerative Diseases
We studied tracer distributions in positron emission tomography of ligands for dopamine D 1 receptors ([ 11 C]SCH23390) and D 2 receptors ([ 11 C]raclopride) and the dopamine precursor analog 6-[ 18 F]fluoro-L-3,4-dihydroxyphenylalanine ([ 18 F]FDOPA), as a measurement of presynaptic dopaminergic function, in the brain after 6-hydroxydopamine lesioning of the medial forebrain bundle in rats. The unilateral lesions were confirmed behaviorally by methamphetamine- induced rotation 2 weeks after lesioning, and the brains were analyzed by tissue dissection following an intravenous bolus of each tracer 3 weeks after lesioning. [ 11 C]Raclopride, but not [ 11 C]SCH23390, showed a higher accumulation in the striatum on the lesion side compared with that on the non-lesioned (intact) side. On the other hand, a lower accumulation of [ 18 F]FDOPA was found in the striatum and cerebral cortex on the lesion side. Our studies demonstrate upregulation of dopamine D 2 receptors in the striatum and a decrease in FDOPA uptake in both the striatum and cerebral cortex ipsilateral to the 6-hydroxydopamine lesions. Therefore, the combination of a D 2 antagonist and FDOPA may provide a potentially useful method for assessing the effects of dopamine depletion in Parkinson's disease. Copyright © 2004 S. Karger AG, Basel.
DOI： 10.1159/000080051
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パーキンソン病モデルラットにおける痛覚過敏 Reviewed
武田龍一郎，石田康，橋口浩志，西森利數
Progress in medicine 22 ( 11 ) 2905 - 2909 2002.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Ishida Y., Hashiguchi H., Takeda R., Ishizuka Y., Mitsuyama Y., Kannan H., Nishimori T., Nakahara D.
Synapse 45 ( 1 ) 46 - 51 2002.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Synapse
Many studies have demonstrated that physical or psychological stress can increase Fos expression in brainstem monoaminergic nuclei. Little is known, however, about the extent to which stress increases the expression of Fos in monoaminergic and nonmonoaminergic neurons in the brainstem. We examined the effects of conditioned-fear (CF) stress following mild footshock (FS) as unconditioned stress on Fos expression in the monoaminergic and GABAergic neurons of the ventral tegmental area (VTA), locus coeruleus (LC), and dorsal raphe nucleus (DR) in rats. The CF stress significantly increased the number of Fos-positive (Fos+) cells in both the LC and DR, whereas it did not increase the number in the VTA. Using a double-labeling technique, we combined Fos immunostaining with that for tyrosine hydroxylase (TH), serotonin (5-HT), or GABA for histochemical identification of the CF stress-induced Fos+ neurons. The percentage of TH/Fos double-labeled cells resulting from CF stress was 63% of the Fos+ cells in the LC, whereas 52% of the Fos+ cells contained 5-HT in the DR. We also found that approximately 60% of the CF stress-induced Fos+ cells were GABAergic neurons in these brain regions. These results indicate that CF stress induces intense Fos expression in the noradrenergic LC and serotonergic DR neurons, but not in the dopaminergic VTA neurons. They also indicate that not only monoaminergic neurons but also GABAergic neurons within the LC and DR are activated by the stress. © 2002 Wiley-Liss, Inc.
DOI： 10.1002/syn.10086
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フェノバルビタールとの相互作用によりフェニトイン中毒を呈したと診断された１症例 Reviewed
武田 龍一郎，植田 勇人，武藤 仁，熊谷 有紀，児玉 裕文，有森 和彦，三山 吉夫
九州精神神経医学雑誌:-; 2001. 47 83 - 90 2001.12
Language：Japanese Publishing type：Research paper (scientific journal)
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精神障害者の身体合併症への対応 Reviewed
武田龍一郎、三山吉夫
精神医学 41 ( 5 ) 547 - 552 1999.5
Language：Japanese Publishing type：Research paper (scientific journal)