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Faculty of Medicine College Hospital Department of Gastroenterology |
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HASUIKE Satoru
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Degree 【 display / non-display 】
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博士（医学） ( 2005.6 宮崎大学 )
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学士（医学） ( 1994.3 宮崎大学 )
Papers 【 display / non-display 】
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Reactivation of hepatitis C virus caused by steroid monotherapy for sudden deafness Reviewed
Kaneko H., Ozono Y., Iwakiri H., Hatada H., Uchiyama N., Komaki Y., Nakamura K., Hasuike S., Nagata K., Kawakami H.
Clinical Journal of Gastroenterology 17 ( 3 ) 505 - 510 2024.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Clinical Journal of Gastroenterology
Hepatitis C virus (HCV) reactivation has been reported to be caused due to several anticancer drugs and immunosuppressive agents; however, HCV reactivation after steroid monotherapy has rarely been reported. Here, we report the case of a 65-year-old Japanese man with HCV infection who developed HCV reactivation after the administration of prednisolone (PSL) for 6 days for sudden deafness. In the patient history, the positivity for anti-HCV antibody was observed, but serum level of HCV RNA was not measured. Two months after PSL administration, the patient experienced an alanine aminotransferase (ALT) flare and the serum level of HCV RNA was observed to be 6.2 log IU/mL; then, the patient was admitted to our hospital for hepatitis treatment. Based on the clinical course and laboratory findings, the patient was diagnosed with HCV reactivation. Although the ALT levels decreased spontaneously during follow-up, they did not drop to normal range; subsequently, sofosbuvir and ledipasvir treatments were started. A sustained virological response 24 weeks after the end of treatment was achieved. This case study suggests that HCV reactivation with hepatitis flare can occur even after a steroid monotherapy, and doctors should pay attention to HCV reactivation when administering PSL for patients with HCV infection.
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Hasuike S., Ozono Y., Uchida K., Ogawa S., Tamura H., Uchiyama N., Hatada H., Komaki Y., Nakamura K., Iwakiri H., Sueta M., Nagata K., Toyoki Nishimura , Matsuyama M., Sawada H., Oguri T., Sato Y., Kawakami H.
Medicine (United States) 103 ( 22 ) e38383 2024.5
Language：English Publishing type：Research paper (scientific journal) Publisher：Medicine (United States)
Background: Nonalcoholic steatohepatitis (NASH) is an important etiology of hepatocellular carcinoma (HCC), and there is no established therapy for this syndrome. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor (ROHHAD(NET)) is an extremely rare syndrome considered to be life-threatening, with death occurring around 10 years of age. We present the oldest known autopsy case of this syndrome that developed HCC. This case provided important information on not only improving the course of this syndrome, but also understanding the natural history and therapeutic modalities of NASH and HCC. Methods: The patient was diagnosed with ROHHAD(NET) syndrome in childhood, and liver cirrhosis due to NASH was diagnosed at age 17. HCC was detected at age 20, and embolization and irradiation were performed. At age 21, she died from accidental acute pancreatitis and subsequent liver failure and pulmonary hemorrhage. Results: Rapid onset of obesity, hypoventilation, and hypothalamic disturbance appeared in childhood and was diagnosed as this syndrome. At age 17, liver cirrhosis due to NASH was diagnosed by liver biopsy, and at age 20, HCC was diagnosed by imaging. Transarterial chemoembolization and irradiation were performed, and the HCC was well controlled for a year. Conclusion: At age 21, she died from accidental acute pancreatitis, subsequent liver failure and pulmonary hemorrhage. Autopsy revealed that the HCC was mostly necrotized. This case was valuable not only for other ROHHAD(NET) syndrome cases, but also in improving our understanding of the natural history of NASH and HCC.
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Inflammatory Hepatocellular Adenoma Mimicking Focal Nodular Hyperplasia that Grew during Pregnancy and Changed its Appearance on Magnetic Resonance Imaging after Delivery Reviewed
Hasuike Satoru, Nagata Kenji, Sasaki Haruka, Hirata Tomoya, Suzuki Sho, Komaki Yuri, Ozono Yoshinori, Nakamura Kenichi, Miike Tadashi, Iwakiri Hisayoshi, Sueta Mitsue, Yamamoto Shojiro, Maekawa Kazuya, Kawakami Hiroshi
Internal Medicine advpub ( 0 ) 2023.4
Authorship：Lead author Language：English Publishing type：Case report Publisher：The Japanese Society of Internal Medicine
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A case of hyperammonemia occurring during treatment of metastatic renal cell carcinoma with axitinib Reviewed
Kimura S., Fujisaki Y., Onizuka C., Hasuike S., Sato Y., Mukai S., Kamoto T.
IJU Case Reports 2023
Language：English Publishing type：Case report Publisher：IJU Case Reports
Introduction: Although the incidence of hyperammonemia as an adverse event of tyrosine kinase inhibitors is quite low, several cases of tyrosine kinase inhibitor associated hyperammonemia have been reported. We report a case of hyperammonemia, that occurred during combined treatment with axitinib and pembrolizumab in a metastatic renal cell carcinoma patient without hepatic disorder or liver metastases. Case presentation: A 77-year-old Japanese woman was diagnosed with metastatic renal cell carcinoma and was treated with pembrolizumab and axitinib. Both agents were subsequently discontinued due to hyperammonemia with hypothyroidism. After recovery, the patient resumed single-agent therapy with axitinib. However, hyperammonemia and hypothyroidism occurred again, suggesting axitinib-inducible adverse event. After nephrectomy, a lower dose of axitinib was restarted and continued safely for residual metastases under prophylactic treatment with aminoleban, lactulose, and levothyroxine. Conclusion: The rare occurrence of hyperammonemia should be considered during treatment with VEGFR- targeted tyrosine kinase inhibitor including axitinib, and supportive prophylactic medication may be useful.
DOI： 10.1002/iju5.12586
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TAMURA Hotaka, OZONO Yoshinori, UCHIYAMA Naomi, HATADA Hiroshi, NAKAMURA Kenichi, IWAKIRI Hisayoshi, HASUIKE Satoru, NAGATA Kenji, KAWAKAMI Hiroshi
Nippon Shokakibyo Gakkai Zasshi 120 ( 6 ) 500 - 507 2023
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Gastroenterology
An 82-year-old female patient was admitted to our hospital for visual acuity loss in both eyes. The patient was diagnosed with invasive liver abscess syndrome and bilateral endophthalmitis due to <i>Klebsiella pneumoniae</i> 4 days after the onset of ocular symptoms. The liver abscess improved by broad-spectrum antibiotics and intravitreal injection, but bilateral blindness occurred. Most literature reported fever as the first symptom of invasive abscess syndrome, but this case had no fever at the onset of ocular symptoms. Delayed invasive liver abscess syndrome diagnosis might cause poor visual acuity prognosis.
Books 【 display / non-display 】
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看護のための最新医学講座 肝・胆・膵疾患
坪内 博仁,蓮池 悟（ Role： Joint author , 主要症候とその発生機序 黄疸、腹水、吐下血、肝脾腫、肝生脳症、出血傾向、皮膚症状）
中山書店 2005.3
Language：Japanese Book type：Scholarly book
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分子消化器病学研究会 第12回浜名湖シンポジウム記録集
坪内 佳子,井戸 章雄,宇都 浩文,沼田 政嗣,森内 昭博,金 一徳,蓮池 悟,永田 賢治,林 克裕,坪内 博仁（ Role： Joint author , 遺伝性高αフェトプロテイン血症の二家系における遺伝子解析）
アークメディア 2005.12
Language：Japanese Book type：Scholarly book
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敗血症の診断/治療の実状と病態・メカニズムをふまえた開発戦略
蓮池悟, 大園芳範, 下田和哉（ Role： Joint author）
技術情報協会 2013.8
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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Managements for chronic liver failure due to liver cirrhosis
Ido A,Hasuike S,Nagata K,Tsubouchi H
54 ( 3 ) 599 - 605 2005.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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Diagnosis and treatment strategy of fulminant hepatic failure
Hasuike S,Ido A,Uto H,Tsubouchi H
51 ( 1 ) 37 - 45 2005.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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Streptococcus constellatusによる肝膿瘍をきたした小腸GISTの１例 （共著）
三池忠, 山本章二朗, 田原良博, 蓮池悟, 船ヶ山まゆみ, 前原直樹, 田中弘之, 秋山裕, 千々岩一男, 下田和哉
日本消化器病学会雑誌 2014.7
Language：Japanese Publishing type：Research paper, summary (national, other academic conference) Publisher： 一般財団法人 日本消化器病学会
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Portal vein thrombosis during eltrombopag treatment for immune thrombocytopenic purpura in a patient with liver cirrhosis due to hepatitis C viral infection
Kawano N,Hasuike S, Iwakiri H, Nakamura K, Ozono Y, Kusumoto H, Nagata K,Kikuchi I, Yoshida S, Kuriyama T,Yamashita K, Muranaka T, Kawaguchi T, Sata M, Okamura T, Ueda A, Shimoda K
Journal of Clinical and Experimental Hematopathology .53(2) 2013.8
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本リンパ網内系学会
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Reactivation of hepatitis B virus in a hepatitis B surface antigen-negative patient with membranous nephropathy treated with immunosuppression ["jointly worked"]
54 ( 1 ) 74 - 80 2013.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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潰瘍性大腸炎術後13年目に発症し、インフリキシマブが奏功した重度の回腸嚢炎の1例
佐々木良子、山本章二朗、安倍弘生、野田裕子、野田貴穂、鈴木翔、上原なつみ、竹田幸子、坂口舞、夏田朱一郎、橋本神奈、前村幸輔、山路卓巳、三池忠、岩切久芳、田原良博、蓮池悟、永田賢治、下田和哉
第104回日本消化器病学会九州支部例会 (大分市) 日本消化器病学会九州支部
Event date： 2014.12.5 - 2014.12.6
Language：Japanese Presentation type：Oral presentation (general)
Venue：大分市
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テラプレビル3剤併用療法施行患者におけるHCV薬剤耐性遺伝子変異と治療成績に関する検討
大園芳範、永田賢治、山田優里、土持舞依、岩切久芳、末田光恵、蓮池悟、楠元寿典、下田和哉
第104回日本消化器病学会九州支部例会 (大阪市) 日本消化器病学会九州支部
Event date： 2014.12.5 - 2014.12.6
Language：Japanese Presentation type：Oral presentation (general)
Venue：大阪市
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胃全摘後に生じた食道空腸吻合部静脈瘤の1例
野田貴穂、岩切久芳、野田裕子、山田優里、大園芳範、土持舞依、山本章二朗、蓮池悟、永田賢治、下田和哉
第104回日本消化器病学会九州支部例会 (大分市) 日本消化器病学会九州支部
Event date： 2014.12.5 - 2014.12.6
Language：Japanese Presentation type：Oral presentation (general)
Venue：大分市
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家族性地中海熱非典型例の加療中に腸管ベーチェット病を合併した1幼児例
平田智也、山本章二朗、野田貴穂、野田裕子、鈴木翔、上原なつみ、竹田幸子、夏田朱一郎、坂口舞、前村幸輔、橋本神奈、山路卓巳、三池忠、安倍弘生、岩切久芳、田原良博、蓮池悟、永田賢治、下田和哉
第104回日本消化器病学会九州支部例会 (大分市) 日本消化器病学会九州支部
Event date： 2014.12.5 - 2014.12.6
Language：Japanese Presentation type：Oral presentation (general)
Venue：大分市
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本態性血小板増多症により肝外門脈閉塞症をきたし、繰り返す静脈瘤出血に対して脾摘術後ハイドレアを投与した1例
興梠聡志、永田賢治、山田優里、大園芳範、土持舞依、岩切久芳、末田光恵、蓮池悟、大谷和広、近藤千博、下田和哉
第104回日本消化器病学会九州支部例会 (大分市) 日本消化器病学会九州支部
Event date： 2014.12.5 - 2014.12.6
Language：Japanese Presentation type：Oral presentation (general)
Venue：大分市
Grant-in-Aid for Scientific Research 【 display / non-display 】
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遺伝子改変動物を用いたオステオアクチビンの肝発癌・線維化に及ぼす影響の解析
Grant number：17790456 2005.04 - 2006.03
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
遺伝子改変動物を用いたオステオアクチビンの肝発癌・線維化に及ぼす影響の解析を行った。
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遺伝子改変動物を用いたオステオアクチビンの肝発癌・線維化に及ぼす影響の解析
Grant number：17790456 2005.04
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
遺伝子改変動物を用いたオステオアクチビンの肝発癌・線維化に及ぼす影響の解析を行った。