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Faculty of Medicine School of Medicine Department of Hemovascular Medicine and Artificial Organs |
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Degree 【 display / non-display 】
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博士(医学) ( 2000.3 宮崎医科大学 )
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学士(医学) ( 1992.3 宮崎医科大学 )
Papers 【 display / non-display 】
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Dissolving Amyloid Fibrils with Natural Deep Eutectic Solvents: Citric Acid-Glycerol Achieves Superior Solubilization and Partial Protein Refolding. Reviewed
Hirano S, Oshima T, Inada A, Tsuruda T
ACS applied bio materials 9 ( 7 ) 3564 - 3572 2026.4
Language:English Publishing type:Research paper (scientific journal)
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宮崎大学におけるJMECCの開催状況と課題 Reviewed
宮内俊一、力武雄幹、落合彰子、安部弘生、鶴田敏博、小松弘幸
宮崎県内科医会誌 2026.4
Publishing type:Research paper (scientific journal)
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A Single-Kindred Cluster of Val122Ile Transthyretin Amyloid Cardiomyopathy: Subclinical Case Series of Three Japanese Patients Reviewed
Tsuruda Toshihiro, Tanahashi Toshihiro, Kodama Narukuni, Suiko Yosuke, Komaki Soichi, Yamamoto Kinuko, Moribayashi Kohei, Terakawa Chiharu, Sakai Katsuya, Iwai Minayo, Terada Tamasa, Shiomi Kazutaka, Nakada Hiroshi, Tanaka Miyo, Yamashita Atsushi, Iida Hiroyuki, Matsuura Yunosuke, Kaikita Koichi, Ogata Miyuki
Internal Medicine advpub ( 0 ) 2026.3
Language:English Publishing type:Research paper (scientific journal) Publisher:The Japanese Society of Internal Medicine
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Matsuura Yunosuke, Tanaka Hiroki, Yamamoto Kinuko, Komaki Soichi, Yamaguchi Masashi, Moribayashi Kohei, Ideguchi Takeshi, Nakai Michikazu, Kaikita Koichi, Tsuruda Toshihiro
Circulation Reports 8 ( 3 ) 453 - 460 2026.3
Language:English Publishing type:Research paper (scientific journal) Publisher:The Japanese Circulation Society
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Basal inferoseptal longitudinal strain deformation may indicate early cardiac involvement in wild-type carpal ATTR Reviewed International journal
Toshihiro Tsuruda,Tomomi Ota,Tamasa Terada,Hiroshi Nakada,Miyuki Ogata,Miyo Tanaka,Yosuke Suiko,Yunosuke Matsuura,Soichi Komaki,Kohei Moribayashi,Rina Yamada,Atsushi Yamashita, Keisuke Yamamoto,Kensaku Nishihira,Yoshisato Shibata,Koichi Kaikita
ESC Heart Failure 13 ( 2 ) 2026.2
Authorship:Lead author Language:English Publishing type:Research paper (scientific journal) Publisher:Oxford University Press
BACKGROUND AND AIMS: Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) is now increasingly identified as a cause of heart failure in older adults. This study aimed to clarify the morphological and functional alterations of the left ventricle (LV) that define the early stage of this condition. METHODS: We prospectively evaluated 81 patients diagnosed with wild-type ATTR (ATTRwt) amyloidosis (mean age 77 ± 6 years; 88% male), categorized into three groups based on myocardial uptake on radioactive pyrophosphate scintigraphy and histological confirmation: (i) carpal ATTR without cardiac involvement (Group 1, n = 13), (ii) asymptomatic cardiac involvement (Group 2, n = 10) and (iii) overt heart failure (Group 3, n = 58). RESULTS: Compared with Group 3, Group 1 showed higher absolute global longitudinal strain (GLS) (median 19.0 [13.2-23.8]%, P < .001), a lower apical-sparing ratio (median 0.66 [0.55-1.04], P < .001) and lower brain natriuretic peptide (BNP) (median 13.5 [6-49] pg/mL, P < .001) and troponin-T concentrations (0.012 [0.006-0.022] ng/mL, P < .001), while the estimated glomerular filtration rate remained preserved (64 ± 9 mL/mL/1.73 m², P = .022). Segmental longitudinal strain (LS) differentiated Group 1 from Group 2, with basal inferoseptal LS significantly lower in patients with elevated troponin-T (> 0.014 ng/mL) than in those with lower values (13.9 ± 5.6% vs. 7.4 ± 1.8%, P = .046) in Group 1. A basal inferoseptal LS cutoff of 9.1% identified high troponin-T with an area under the curve (AUC) of 0.833 (P = .005), outperforming GLS (AUC 0.306, P = .217), BNP (AUC 0.667, P = .292), and LV ejection fraction (AUC 0.556, P = .743). CONCLUSIONS: Basal inferoseptal LS impairment may indicate early cardiac involvement in individuals with carpal tunnel syndrome carrying ATTRwt deposits.
Books 【 display / non-display 】
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バイスタンダーCPRの生命・機能予後に関する横断研究-宮崎市消防局管内で発生した心肺機能停止1,686年の解析-
鶴田敏博、濱畑貴晃、遠藤穣治、海北幸一( Role: Joint author)
宮崎県医師会 2023.10
Language:Japanese Book type:Scholarly book
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人々を繋ぎ、宮崎県から世界へ~これからの東九州メディカルバレー構想と宮崎大学の医工連携事業 Reviewed
鶴田敏博、平山麻美、小牧聡一、中村小夜子、宮田敬公、金子彰彦、福永千紗、岩本脩成、森田 徹、荒武 尚( Role: Joint author)
宮崎県医師会 2023.3
Responsible for pages:112-116 Language:Japanese Book type:Scholarly book
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宮崎大学学生の医療機器開発への関心についての調査
平山麻美、鶴田敏博、小牧聡一、中村小夜子、宮田敬公、金子彰彦、福永千紗、岩本脩成、森田 徹、荒武 尚( Role: Joint author)
宮崎県医師会 2023.3
Language:Japanese Book type:Scholarly book
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腎保護薬update 可溶性グアニル酸シクラーゼ刺激薬
鶴田敏博( Role: Sole author)
東京医学社 2021.8
Language:Japanese Book type:Scholarly book
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Current Therapy in Cardiovascular Diseases
( Role: Joint author)
2020.1
Total pages:3 Responsible for pages:295-297 Language:Japanese Book type:Scholarly book
MISC 【 display / non-display 】
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心不全の基礎研究.心不全の分子機序.神経体液性因子.アドレノメデュリン Invited
鶴田敏博、北村和雄
日本臨床社 76 ( 9 ) 136 - 143 2018
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal)
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骨と心血管を巡る破骨細胞形成抑制因子、「オステオプロテゲリン」 Invited
鶴田敏博、宇田川信之、北村和雄
循環制御 39 ( 3 ) 157 - 159 2018
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:日本循環制御学会
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What are the clinical consequences of hyperkalemia on the heart and what are the uses of electrocardiograms in hyperkalemia?
Ideguchi T, Tsuruda T
E-journal of Cardiology Practice 14 12 2016.6
Language:English Publishing type:Research paper, summary (national, other academic conference) Publisher:European society of cardiology
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Guanylate cyclase on renal protection; update
Tsuruda T, Kitamura K
Kidney and Dialysis 80 ( 4 ) 556 - 560 2016.4
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher:Tokyo-igakusha.co.jp
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ストローマからみた心血管病「序文」
北村和雄、鶴田敏博
循環器内科 74 123 - 124 2013.8
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:科学評論社
Presentations 【 display / non-display 】
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見逃さないATTR-CM、途切れさせない連携 宮崎での実践と最新データ Invited
鶴田敏博
第139回日本循環器学会九州地方会スイーツセミナー 2025.12.6
Event date: 2025.12.6
Language:Japanese Presentation type:Oral presentation (invited, special)
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Characterization of left ventricular 2-dimentional strain imaging in carpal tunnel syndrome associated with wild-type transthyretin amyloidosis International conference
Toshihiro Tsuruda
ESC Congress 2025
Event date: 2025.8.29 - 2025.9.1
Language:English Presentation type:Oral presentation (general)
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区域ストレイン解析からトランスサイレチン型心アミロイドーシスの病態を理解する
鶴田敏博、田中美与、尾方美幸、海野光佑、伊藤芽生、海北幸一
日本超音波医学会第98回学術集会 2025.5.30
Event date: 2025.5.30 - 2025.6.1
Presentation type:Oral presentation (general)
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Segmental Analysis of 2-dimensional Speckle-tracking Echocardiography in Clinical Spectrum of Transthyretin-derived Amyloid Cardiomyopathy.
鶴田敏博
第89回日本循環器学会学術集会 2025.3.30
Event date: 2025.3.28 - 2025.3.30
Presentation type:Poster presentation
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Basal inferior-septal segment is highly susceptible to deformation in the clinical spectrum of transthyretin-derived cardiomyopathy International conference
鶴田敏博
ESC Congress 2024 2024.8.31
Event date: 2024.8.30 - 2024.9.2
Language:English Presentation type:Oral presentation (general)
Awards 【 display / non-display 】
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第38回医学賞
2024.2 宮崎県医師会 バイスタンダーCPRの生命・機能予後に関する横断研究-宮崎市消防局管内で発生した心肺機能停止1,686件の解析-
鶴田敏博
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第53回高血圧関連疾患モデル学会会長賞
2017 高血圧関連疾患モデル学会
鶴田敏博
Award type:Award from Japanese society, conference, symposium, etc. Country:Japan
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第120回日本循環器学会九州地方会トランスレーショナルリサーチセッション優秀賞
2016.6 日本循環器学会九州支部
鶴田敏博
Award type:Award from Japanese society, conference, symposium, etc. Country:Japan
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Best Poster in the Basic/ Translational Domain ACC Geriatric Cardiology Member Section
2016.4 American College of Cardiology
Tsuruda T
Award type:Award from international society, conference, symposium, etc. Country:United States
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Best poster award (neurohormones) at European Society of Cardiology Congress
2015.8 European Society of Cardiology
Tsuruda T
Award type:Award from international society, conference, symposium, etc. Country:United Kingdom
Grant-in-Aid for Scientific Research 【 display / non-display 】
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新生児スクリーニングを契機に発見される家系内ファブリー病症例のコホート研究
Grant number:25K13371 2025.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship:Coinvestigator(s)
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骨芽細胞のビタミンD受容体が制御するCa・P代謝異常フレイル様病態の責任分子同定
Grant number:24K02618 2024.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship:Coinvestigator(s)
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ナトリウム利尿ペプチド(NPs)は心肥大を促進しうるか
Grant number:23K07581 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
加藤 丈司
Authorship:Coinvestigator(s)
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Role of Cardiac Troponin-T Expression in Cancer Tissues
Grant number:22K08128 2022.04 - 2025.03
Authorship:Principal investigator
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心不全・動脈瘤の発症/進展におけるオステオプロテゲリンの関与
Grant number:26461076 2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship:Principal investigator
心不全・動脈瘤の発症/進展におけるオステオプロテゲリンの関与