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Faculty of Medicine School of Medicine Department of Hemovascular Medicine and Artificial Organs |
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TSURUDA Toshihiro
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Degree 【 display / non-display 】
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博士（医学） ( 2000.3 宮崎医科大学 )
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学士（医学） ( 1992.3 宮崎医科大学 )
Papers 【 display / non-display 】
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Patient Characteristics and Diagnosis of Transthyretin Amyloid Cardiomyopathy in Japan Reviewed
Endo J., Tanzawa K., Sato Y., Watanabe H., Takashio S., Kubo T., Minamisawa M., Tanaka H., Hashimoto T., Kawano H., Sakata K., Kanamori H., Tsuruda T., Fukata M., Kitagawa T., Noma T., Okada A., Kitai T., Yajima A., Iwataki M., Kondo H., Yamada Y., Ishii S., Izumiya Y., Ieda M., Kuwahara K., Nakamura K., Tahara N., Ueda M., Sekijima Y., Naiki H., Tsujita K., Kitaoka H., Inomata T.
Jacc Asia 6 ( 8 ) 1553 - 1566 2026.8
Language：English Publishing type：Research paper (scientific journal) Publisher：Jacc Asia
Background Large-scale, nationwide data for patients with transthyretin amyloid cardiomyopathy (ATTR-CM) in Japan are limited. Objectives This multicenter observational, retrospective cohort study ( UMIN000056734 ) assessed the clinical characteristics and diagnostic landscape of patients with ATTR-CM in Japan. Methods A subcohort of patients with biopsy-proven ATTR-CM initiated on tafamidis from the J-COSSA (Japan Cohort Study of Systemic Amyloidosis) was evaluated (120 sites; April 2020 to January 2024). Baseline characteristics and investigations for the diagnosis of ATTR-CM were recorded. Results Overall, 1,506 patients with ATTR-CM (median [range, IQR] age, 78 [48-94, 74-82] years [n = 1,391]; men 88.9% [1,337 of 1,504]) were registered: wild-type transthyretin amyloidosis (ATTRwt), 97.9% (1,475 of 1,506); hereditary (variant) transthyretin amyloidosis (ATTRv), 2.0% (30 of 1,506); New York Heart Association (NYHA) functional class I or II, 86.6% (747 of 863); interventricular septum thickness, 15.3 ± 2.7 mm; left ventricular posterior wall thickness, 14.9 ± 2.8 mm; M protein test availability, 838 of 994 (84.3%; 30 [3.6%] tested positive); and endomyocardial biopsy, 858 (83.4% of 1,029 biopsy records). Among patients with evaluable records, technetium-99m (<sup>99m</sup>Tc)-labeled scintigraphy was performed in 796 (80.1%) of 994 patients, of whom single-photon emission computed tomography was performed in 652 (81.9%) patients (Perugini grade 3, 657 [82.5%]). Among the 993 patients with evaluable records, 521 (52.5%) had ≥5 symptoms among the 7 red-flag symptoms. Conclusions This nationwide study clarified the clinical characteristics and diagnostic landscape of patients with biopsy-proven ATTR-CM in Japan. The results indicate that noninvasive testing is implemented for early ATTR-CM diagnosis in clinical practice and reiterate the importance of biomarkers and imaging data for early disease diagnosis.
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Regional Myocardial Tissue Characterization by Cardiac Magnetic Resonance Is Associated With Heart Failure Development in Asymptomatic Transthyretin Amyloid Cardiomyopathy Reviewed
Tsuruda Toshihiro, Nakada Hiroshi, Suiko Yosuke, Matsuura Yunosuke, Komaki Soichi, Moribayashi Kohei, Tanaka Hiroki, Yamaguchi Masashi, Yamamoto Kinuko, Ideguchi Takeshi, Ogata Miyuki, Tanaka Miyo, Terada Tamasa, Kawano Masatsugu, Ota Tomomi, Yamashita Atsushi, Yamamoto Keisuke, Nishihira Kensaku, Shibata Yoshisato, Kaikita Koichi
Circulation Reports advpub ( 0 ) 2026.7
Language：English Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本循環器学会
<b><i>Background:</i></b> Because the number of asymptomatic individuals diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM) has been rising, it is important to identify myocardial tissue characteristics associated with heart failure (HF) development in asymptomatic patients with ATTR-CM.<b><i>Methods and Results:</i></b> Among 113 patients with ATTR-CM, 14 were asymptomatic (mean age 75±6 years; 79% male) and underwent echocardiography and cardiac magnetic resonance imaging (CMR). Over a median follow-up of 770 days, 6 patients developed HF. Compared with those who remained asymptomatic, these patients had a higher left ventricular mass index (LVMI) on echocardiography (P=0.020). On CMR, native T1 was significantly higher at the basal inferior (P=0.0277) and inferolateral (P=0.0017) segments, whereas the extracellular volume (ECV) fraction was significantly higher at the basal inferolateral (P=0.0296) and anterolateral (P=0.0092) segments. LVMI correlated with native T1 (r=0.599, P=0.024) and ECV at the basal inferolateral (r=0.780, P<0.001) and anterolateral (r=0.624, P=0.017) segments. Kaplan–Meier analysis showed that patients with higher LVMI, native T1 at the basal inferolateral segment, and ECV at the basal anterolateral segment had a higher incidence of HF development.<b><i>Conclusions:</i></b> In asymptomatic ATTR-CM patients, HF development was associated with increased LVMI and regional myocardial tissue abnormalities in the basal lateral wall detected by native T1 and ECV on CMR; however, these findings should be considered exploratory and require validation in larger studies.
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鶴田 敏博
European heart journal open 6 ( 3 ) oeag079 2026.5
Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press
Immune checkpoint inhibitors (ICIs) are a cornerstone of cancer therapy; however, immune-related adverse events, including myocarditis, pose significant challenges. Furthermore, limited data exist on the pathology of mild or asymptomatic cases. This study aimed to characterize the clinical, biomarker, and pathological features of ICI-associated cardiac toxicity, comparing symptomatic and asymptomatic cases within a Japanese multicentre registry./A nationwide, retrospective registry collected data from 90 patients across 23 hospitals between 2020 and 2022. Patients were classified according to the American Society of Clinical Oncology Clinical Practice Guidelines: Grade 1 (asymptomatic) and Grades 2-4 (symptomatic). Endomyocardial biopsy was performed in 24 patients (n = 19 symptomatic, n = 5 asymptomatic). Among the enrolled patients (mean age: 68 years; 76.7% male), 41.1% were classified as Grade 1, whereas 58.9% were symptomatic (Grades 2-4). Symptomatic cases exhibited significantly higher troponin I and creatine kinase levels at onset. Pathological analysis revealed more extensive lymphocytic infiltration (CD3+ T cells) in symptomatic cases, particularly with higher CD8+ and CD68+ cell counts. Continuation of ICI therapy was more frequent in the asymptomatic group, and only one patient experienced recurrence. In contrast, all seven myocarditis-related deaths occurred in symptomatic patients./This study provides one of the largest pathological and biomarker-based comparisons of symptomatic and asymptomatic ICI-associated cardiac toxicity. Our findings suggest that asymptomatic cases may represent a distinct, less aggressive inflammatory phenotype, characterized by lower CD8+ infiltration and limited myocardial damage.
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水光 洋輔, 尾方 美幸, 松浦 祐之介, 鶴田 敏博, 海北 幸一
Journal of the American Heart Association 15 ( 9 ) e042486 2026.4
Language：English Publishing type：Research paper (scientific journal) Publisher：Wolters Kluwer Health
Background
Left atrial functional parameters are established predictors of atrial fibrillation (AF), but the role of right atrial (RA) function, particularly RA peak longitudinal strain (LS), in transthyretin amyloid cardiomyopathy (ATTR‐CM) remains unclear. This study aimed to investigate the relationship between RA function and AF onset in ATTR‐CM.
Methods
The derivation cohort comprised 143 patients with ATTR‐CM without prior atrial arrhythmias at Kumamoto University Hospital. Association between baseline parameters and new‐onset AF during the follow‐up period was analyzed using Cox regression models. Discrimination was assessed using time‐dependent receiver operating characteristic analysis at 24 months.
Results
During follow‐up (median, 30 months), 42 patients (29%) developed new‐onset AF. Lower RA peak LS was independently associated with incident AF and showed moderate discrimination (time‐dependent area under the curve, 0.72); the optimal cutoff at 24 months was 17.2%. Patients with RA peak LS <17.2% had significantly lower AF‐free survival. A novel risk score integrating RA and left atrial peak LS and LA volume index effectively stratified AF risk. External validation in an independent cohort of 81 patients from Oita and Miyazaki University Hospitals confirmed consistent associations between lower RA peak LS and higher AF incidence, supporting the reproducibility of the findings.
Conclusions
RA peak LS is a novel, robust predictor of new‐onset AF in ATTR‐CM and provides additional information alongside established clinical and left atrial parameters. Incorporating RA functional assessment may improve risk stratification and guide early interventions in high‐risk patients. -
Hirano S, Oshima T, Inada A, Tsuruda T
ACS applied bio materials 9 ( 7 ) 3564 - 3572 2026.4
Language：English Publishing type：Research paper (scientific journal) Publisher：ACS Applied Bio Materials
Amyloid protein aggregates pose a significant challenge due to their extreme insolubility and association with neurodegenerative diseases. To identify effective solvents for dissolving amyloid-forming proteins, a screening of deep eutectic solvents (DESs), including natural DESs (NADES), and related solvents was conducted. Aggregated lysozyme (LA) was reproducibly prepared under acidic and thermal conditions as a model of poorly soluble protein aggregates. Spectroscopic analyses using Thioflavin T fluorescence and circular dichroism (CD), along with morphological observations under polarized light and SEM, confirmed the formation of β-sheet-rich amyloid-like structures. The citric acid−glycerol DES showed the highest solubility for LA, outperforming other DESs and DMSO. Its performance was further enhanced by the addition of ∼5% water. This result also suggests a strong contribution of multivalent organic acids, such as citric and malic acid, to protein solubilization. CD analysis indicated that lysozyme recovered a native-like secondary structure, suggesting partial structural recovery after dissolution in this DES. These findings highlight the potential of DESs as effective media for dissolving protein aggregates and suggest their possible utility in protein refolding and related biotechnological applications, including potential future biomedical applications.
Books 【 display / non-display 】
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バイスタンダーCPRの生命・機能予後に関する横断研究－宮崎市消防局管内で発生した心肺機能停止1,686年の解析－
鶴田敏博、濱畑貴晃、遠藤穣治、海北幸一（ Role： Joint author）
宮崎県医師会 2023.10
Language：Japanese Book type：Scholarly book
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人々を繋ぎ、宮崎県から世界へ～これからの東九州メディカルバレー構想と宮崎大学の医工連携事業 Reviewed
鶴田敏博、平山麻美、小牧聡一、中村小夜子、宮田敬公、金子彰彦、福永千紗、岩本脩成、森田 徹、荒武 尚（ Role： Joint author）
宮崎県医師会 2023.3
Responsible for pages：112-116 Language：Japanese Book type：Scholarly book
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宮崎大学学生の医療機器開発への関心についての調査
平山麻美、鶴田敏博、小牧聡一、中村小夜子、宮田敬公、金子彰彦、福永千紗、岩本脩成、森田 徹、荒武 尚（ Role： Joint author）
宮崎県医師会 2023.3
Language：Japanese Book type：Scholarly book
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腎保護薬update 可溶性グアニル酸シクラーゼ刺激薬
鶴田敏博（ Role： Sole author）
東京医学社 2021.8
Language：Japanese Book type：Scholarly book
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Current Therapy in Cardiovascular Diseases
（ Role： Joint author）
2020.1
Total pages：3 Responsible for pages：295-297 Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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心不全の基礎研究．心不全の分子機序．神経体液性因子．アドレノメデュリン Invited
鶴田敏博、北村和雄
日本臨床社 76 ( 9 ) 136 - 143 2018
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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骨と心血管を巡る破骨細胞形成抑制因子、「オステオプロテゲリン」 Invited
鶴田敏博、宇田川信之、北村和雄
循環制御 39 ( 3 ) 157 - 159 2018
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本循環制御学会
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What are the clinical consequences of hyperkalemia on the heart and what are the uses of electrocardiograms in hyperkalemia?
Ideguchi T, Tsuruda T
E-journal of Cardiology Practice 14 12 2016.6
Language：English Publishing type：Research paper, summary (national, other academic conference) Publisher：European society of cardiology
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Guanylate cyclase on renal protection; update
Tsuruda T, Kitamura K
Kidney and Dialysis 80 ( 4 ) 556 - 560 2016.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：Tokyo-igakusha.co.jp
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ストローマからみた心血管病「ストローマをターゲットとした心血管病の治療」
北村和雄、鶴田敏博
循環器内科 74 125 - 131 2013.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：科学評論社
Presentations 【 display / non-display 】
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手根管症候群とトランスサイレチン型心アミロイドーシス:手外科医が担う早期診断の鍵
鶴田敏博
第69回日本手外科学会学術集会 2026.4.9
Event date： 2026.4.9 - 2026.4.10
Presentation type：Public lecture, seminar, tutorial, course, or other speech
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見逃さないATTR-CM、途切れさせない連携 宮崎での実践と最新データ Invited
鶴田敏博
第139回日本循環器学会九州地方会スイーツセミナー 2025.12.6
Event date： 2025.12.6
Language：Japanese Presentation type：Oral presentation (invited, special)
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Characterization of left ventricular 2-dimentional strain imaging in carpal tunnel syndrome associated with wild-type transthyretin amyloidosis International conference
Toshihiro Tsuruda
ESC Congress 2025
Event date： 2025.8.29 - 2025.9.1
Language：English Presentation type：Oral presentation (general)
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区域ストレイン解析からトランスサイレチン型心アミロイドーシスの病態を理解する
鶴田敏博、田中美与、尾方美幸、海野光佑、伊藤芽生、海北幸一
日本超音波医学会第98回学術集会 2025.5.30
Event date： 2025.5.30 - 2025.6.1
Presentation type：Oral presentation (general)
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Segmental Analysis of 2-dimensional Speckle-tracking Echocardiography in Clinical Spectrum of Transthyretin-derived Amyloid Cardiomyopathy.
鶴田敏博
第89回日本循環器学会学術集会 2025.3.30
Event date： 2025.3.28 - 2025.3.30
Presentation type：Poster presentation
Awards 【 display / non-display 】
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第38回医学賞
2024.2 宮崎県医師会 バイスタンダーCPRの生命・機能予後に関する横断研究－宮崎市消防局管内で発生した心肺機能停止1,686件の解析－
鶴田敏博
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第53回高血圧関連疾患モデル学会会長賞
2017 高血圧関連疾患モデル学会
鶴田敏博
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第120回日本循環器学会九州地方会トランスレーショナルリサーチセッション優秀賞
2016.6 日本循環器学会九州支部
鶴田敏博
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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Best Poster in the Basic/ Translational Domain ACC Geriatric Cardiology Member Section
2016.4 American College of Cardiology
Tsuruda T
Award type：Award from international society, conference, symposium, etc. Country：United States
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Best poster award (neurohormones) at European Society of Cardiology Congress
2015.8 European Society of Cardiology
Tsuruda T
Award type：Award from international society, conference, symposium, etc. Country：United Kingdom
Grant-in-Aid for Scientific Research 【 display / non-display 】
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新生児スクリーニングを契機に発見される家系内ファブリー病症例のコホート研究
Grant number：25K13371 2025.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Coinvestigator(s)
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骨芽細胞のビタミンD受容体が制御するCa・P代謝異常フレイル様病態の責任分子同定
Grant number：24K02618 2024.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship：Coinvestigator(s)
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ナトリウム利尿ペプチド（NPs）は心肥大を促進しうるか
Grant number：23K07581 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
加藤 丈司
Authorship：Coinvestigator(s)
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Role of Cardiac Troponin-T Expression in Cancer Tissues
Grant number：22K08128 2022.04 - 2025.03
Authorship：Principal investigator
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心不全・動脈瘤の発症/進展におけるオステオプロテゲリンの関与
Grant number：26461076 2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
心不全・動脈瘤の発症/進展におけるオステオプロテゲリンの関与