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Faculty of Medicine School of Medicine Department of Hemovascular Medicine and Artificial Organs |
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TSURUDA Toshihiro
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Degree 【 display / non-display 】
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博士（医学） ( 2000.3 宮崎医科大学 )
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学士（医学） ( 1992.3 宮崎医科大学 )
Papers 【 display / non-display 】
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Fujimoto S., Koremoto M., Yamamoto S., Umeno H., Sano Y., Tsuruda T.
Artificial Organs 2025
Language：English Publishing type：Research paper (scientific journal) Publisher：Artificial Organs
Background: Several studies have evaluated the biocompatibility of dialysis membranes. The use of vitamin E-coated membranes has been reported multilaterally in in vitro and clinical studies. Nevertheless, the effect of vitamin E-coated membranes on the redox state of serum albumin, which forms the largest fraction of reactive sulfhydryl groups, has not been reported. Methods: Hemodiafiltration (HDF) with and without a vitamin E-coated hemodiafilter (V-RATM group and ABHTM groups, respectively) was performed in an acute kidney injury pig model to determine whether changes in the serum albumin, the oxidized albumin (OxiALB), and the reduced albumin (RedALB) levels differ between the two groups. Results: Analyses were conducted 22–24 times in the V-RATM group and 16–18 times in the ABHTM group, excluding missing data. The serum albumin levels decreased in both groups after nephrectomy; however, the decrease observed in the V-RATM group was significantly lesser than that in the ABHTM group. RedALB levels were significantly higher in the V-RATM group; in contrast, OxiALB levels did not differ between the two groups. A significant positive correlation was observed between the serum albumin and RedALB levels. Conclusions: The present study demonstrated that HDF performed using a vitamin E-coated hemodiafilter effectively minimized the reduction in serum albumin and RedALB levels compared to the vitamin E-non-coated hemodiafilter in an acute kidney injury pig model.
DOI： 10.1111/aor.14982
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野生型トランスサイレチン心アミロイドーシス診療の現在と未来 Reviewed
鶴田敏博
宮崎県内科医会誌 100 2024.10
Authorship：Lead author Publishing type：Research paper (scientific journal)
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Tsuruda T., Nakada H., Yamamura Y., Matsuura Y., Ogata M., Tanaka M., Suiko Y., Komaki S., Tanaka H., Moribayashi K., Ideguchi T., Terada T., Ota T., Yamamoto K., Nishihira K., Shibata Y., Kaikita K.
European Heart Journal Open 4 ( 5 ) oeae076 2024.9
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：European Heart Journal Open
Aims. While the prevalence of transthyretin-derived amyloid cardiomyopathy (ATTR-CM) is on the rise, detailed understanding of its morphological and functional characteristics within the left ventricle (LV) across heart failure (HF) remains limited. Methods and results. Utilizing two-dimensional (2D) speckle-tracking echocardiography, we assessed longitudinal strain (LS) in 63 histology-confirmed ATTR-CM patients. Additionally, cardiac magnetic resonance (CMR) images measured native T1 and extracellular volume (ECV), compared with LS across 18 LV segments. Patients were categorized into three groups based on HF status: Group 1 (no HF symptoms), Group 2 (HF with preserved LV ejection fraction), and Group 3 (HF with reduced LV ejection fraction). LS analysis unveiled susceptibility to deformation in the basal inferoseptal segment, persisting even in asymptomatic cases. CMR demonstrated increasing native T1 deviation, particularly evident in segments distant from the inferoseptal region. Contrastingly, maximal ECV was consistently observed in the basal and mid-ventricular inferior-septum, even in asymptomatic individuals. Segmental LS decline correlated with ECV expansion but not with native T1 values. Conclusion. Our findings suggest that the inferoseptal segment is highly susceptible to amyloid infiltration, and 2D speckle-tracking echocardiography and CMR may serve as a valuable tool for its early detection.
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ビタミンE固定化血液透析濾過器（ヴィエラV-RA)による両腎摘出ブタを用いた貧血抑制作用の検討 Reviewed
佐野裕介、梅野浩、加藤佳久、山本集士、五田嘉倫、藤元昭一、鶴田敏博
腎と透析 97巻別冊 HDF療法2024 97 2024.8
Authorship：Last author Publishing type：Research paper (scientific journal)
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Rewiring of the dissected branch along the jailed balloon technique in provisional stenting for true coronary bifurcation lesions Reviewed
Shintaro Izumoto , Kazumasa Kurogi , Kohei Moribayashi , Soichi Komaki , Yunosuke Matsuura , Nobuyasu Yamamoto , Toshihiro Tsuruda , Koichi Kaikita
Cardiovascular Revascularization Medicine: Interesting Cases Volume 2 2024.6
Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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バイスタンダーCPRの生命・機能予後に関する横断研究－宮崎市消防局管内で発生した心肺機能停止1,686年の解析－
鶴田敏博、濱畑貴晃、遠藤穣治、海北幸一（ Role： Joint author）
宮崎県医師会 2023.10
Language：Japanese Book type：Scholarly book
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人々を繋ぎ、宮崎県から世界へ～これからの東九州メディカルバレー構想と宮崎大学の医工連携事業 Reviewed
鶴田敏博、平山麻美、小牧聡一、中村小夜子、宮田敬公、金子彰彦、福永千紗、岩本脩成、森田 徹、荒武 尚（ Role： Joint author）
宮崎県医師会 2023.3
Responsible for pages：112-116 Language：Japanese Book type：Scholarly book
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宮崎大学学生の医療機器開発への関心についての調査
平山麻美、鶴田敏博、小牧聡一、中村小夜子、宮田敬公、金子彰彦、福永千紗、岩本脩成、森田 徹、荒武 尚（ Role： Joint author）
宮崎県医師会 2023.3
Language：Japanese Book type：Scholarly book
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腎保護薬update 可溶性グアニル酸シクラーゼ刺激薬
鶴田敏博（ Role： Sole author）
東京医学社 2021.8
Language：Japanese Book type：Scholarly book
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Current Therapy in Cardiovascular Diseases
（ Role： Joint author）
2020.1
Total pages：3 Responsible for pages：295-297 Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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心不全の基礎研究．心不全の分子機序．神経体液性因子．アドレノメデュリン Invited
鶴田敏博、北村和雄
日本臨床社 76 ( 9 ) 136 - 143 2018
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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骨と心血管を巡る破骨細胞形成抑制因子、「オステオプロテゲリン」 Invited
鶴田敏博、宇田川信之、北村和雄
循環制御 39 ( 3 ) 157 - 159 2018
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本循環制御学会
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What are the clinical consequences of hyperkalemia on the heart and what are the uses of electrocardiograms in hyperkalemia?
Ideguchi T, Tsuruda T
E-journal of Cardiology Practice 14 12 2016.6
Language：English Publishing type：Research paper, summary (national, other academic conference) Publisher：European society of cardiology
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Guanylate cyclase on renal protection; update
Tsuruda T, Kitamura K
Kidney and Dialysis 80 ( 4 ) 556 - 560 2016.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：Tokyo-igakusha.co.jp
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ストローマからみた心血管病「序文」
北村和雄、鶴田敏博
循環器内科 74 123 - 124 2013.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：科学評論社
Presentations 【 display / non-display 】
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Basal inferior-septal segment is highly susceptible to deformation in the clinical spectrum of transthyretin-derived cardiomyopathy International conference
鶴田敏博
ESC Congress 2024 2024.8.31
Event date： 2024.8.30 - 2024.9.2
Language：English Presentation type：Oral presentation (general)
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Bystander cardiopulmonary resuscitation by nonfamily is associated with neurologically favorable survival after out-of-hospital cardiac arrest in Miyazaki city district
Tsuruda T, Endo GJ, Kaikita K
第87回日本循環器学会学術集会 2023.3.10
Event date： 2023.3.10 - 2023.3.12
Language：English Presentation type：Poster presentation
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Cardiac troponin-T is expressed in lung cancer tissues and is associated with pathological severity
Tsuruda T, Hatakeyama K, Asada Y, Kaikita K
第86回日本循環器学会学術集会 2022.3.11
Event date： 2022.3.10 - 2022.3.13
Language：English Presentation type：Oral presentation (general)
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心血管保護因子としてのオステオプロテゲリン Invited
鶴田敏博、小出雅則、中道裕子、中村美どり、宇田川信之、北村和雄
第62回歯科基礎医学会学術大会 2020.9.11
Event date： 2020.9.11 - 2020.9.13
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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ショックを呈した頻脈性心房細動 －確実な一手でバイタル管理－
山村善政、竹内貴哉、黒木建吾、小山彰平、井手口武史、鬼塚久充、鶴田敏博、石川哲憲、北村和雄
第127回 日本循環器学会九州地方会
Event date： 2019.12.7
Language：Japanese Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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第38回医学賞
2024.2 宮崎県医師会 バイスタンダーCPRの生命・機能予後に関する横断研究－宮崎市消防局管内で発生した心肺機能停止1,686件の解析－
鶴田敏博
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第53回高血圧関連疾患モデル学会会長賞
2017 高血圧関連疾患モデル学会
鶴田敏博
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第120回日本循環器学会九州地方会トランスレーショナルリサーチセッション優秀賞
2016.6 日本循環器学会九州支部
鶴田敏博
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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Best Poster in the Basic/ Translational Domain ACC Geriatric Cardiology Member Section
2016.4 American College of Cardiology
Tsuruda T
Award type：Award from international society, conference, symposium, etc. Country：United States
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Best poster award (neurohormones) at European Society of Cardiology Congress
2015.8 European Society of Cardiology
Tsuruda T
Award type：Award from international society, conference, symposium, etc. Country：United Kingdom
Grant-in-Aid for Scientific Research 【 display / non-display 】
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骨芽細胞のビタミンD受容体が制御するCa・P代謝異常フレイル様病態の責任分子同定
Grant number：24K02618 2024.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship：Coinvestigator(s)
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ナトリウム利尿ペプチド（NPs）は心肥大を促進しうるか
Grant number：23K07581 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
加藤 丈司
Authorship：Coinvestigator(s)
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Role of Cardiac Troponin-T Expression in Cancer Tissues
Grant number：22K08128 2022.04 - 2025.03
Authorship：Principal investigator
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心不全・動脈瘤の発症/進展におけるオステオプロテゲリンの関与
Grant number：26461076 2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
心不全・動脈瘤の発症/進展におけるオステオプロテゲリンの関与
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腹部大動脈瘤の病態解明と細胞内エネルギー制御による内科的治療法の基盤確立
Grant number：23591052 2011.04 - 2014.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
（１） 腹部大動脈瘤壁の炎症基盤をPositron emission tomography-computed tomography (PET-CT)で評価し、瘤壁の組織学的・分子生物学的な解析と併せて、腹部大動脈瘤の発症、進展・破裂の病態・機序を明らかにする。
（２） 瘤壁内の炎症細胞（特にマクロファージ）のエネルギー産生調節（グルコース・トランスポーターの発現・糖代謝機能調節）に着眼した新規内科的治療法開発の基盤を確立する。