TSURUDA Toshihiro

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Hemovascular Medicine and Artificial Organs

Title

Professor

External Link

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Degree 【 display / non-display

  • 博士(医学) ( 2000.3   宮崎医科大学 )

  • 学士(医学) ( 1992.3   宮崎医科大学 )

Research Areas 【 display / non-display

  • Life Science / Cardiology

 

Papers 【 display / non-display

  • Dissolving Amyloid Fibrils with Natural Deep Eutectic Solvents: Citric Acid-Glycerol Achieves Superior Solubilization and Partial Protein Refolding. Reviewed

    Hirano S, Oshima T, Inada A, Tsuruda T

    ACS applied bio materials   9 ( 7 )   3564 - 3572   2026.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsabm.5c02553

    PubMed

  • 宮崎大学におけるJMECCの開催状況と課題 Reviewed

    宮内俊一、力武雄幹、落合彰子、安部弘生、鶴田敏博、小松弘幸

    宮崎県内科医会誌   2026.4

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    Publishing type:Research paper (scientific journal)  

  • A Single-Kindred Cluster of Val122Ile Transthyretin Amyloid Cardiomyopathy: Subclinical Case Series of Three Japanese Patients Reviewed

    Tsuruda Toshihiro, Tanahashi Toshihiro, Kodama Narukuni, Suiko Yosuke, Komaki Soichi, Yamamoto Kinuko, Moribayashi Kohei, Terakawa Chiharu, Sakai Katsuya, Iwai Minayo, Terada Tamasa, Shiomi Kazutaka, Nakada Hiroshi, Tanaka Miyo, Yamashita Atsushi, Iida Hiroyuki, Matsuura Yunosuke, Kaikita Koichi, Ogata Miyuki

    Internal Medicine   advpub ( 0 )   2026.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Internal Medicine  

    DOI: 10.2169/internalmedicine.6926-25

    PubMed

    CiNii Research

  • Clinical Determinants and Prognostic Significance of Circulating Angiopoietin-Like Protein 3 Levels in Patients With Chronic Coronary Syndrome

    Matsuura Yunosuke, Tanaka Hiroki, Yamamoto Kinuko, Komaki Soichi, Yamaguchi Masashi, Moribayashi Kohei, Ideguchi Takeshi, Nakai Michikazu, Kaikita Koichi, Tsuruda Toshihiro

    Circulation Reports   8 ( 3 )   453 - 460   2026.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Circulation Society  

    DOI: 10.1253/circrep.CR-25-0264

    PubMed

    CiNii Research

  • Basal inferoseptal longitudinal strain deformation may indicate early cardiac involvement in wild-type carpal ATTR Reviewed International journal

    Toshihiro Tsuruda,Tomomi Ota,Tamasa Terada,Hiroshi Nakada,Miyuki Ogata,Miyo Tanaka,Yosuke Suiko,Yunosuke Matsuura,Soichi Komaki,Kohei Moribayashi,Rina Yamada,Atsushi Yamashita, Keisuke Yamamoto,Kensaku Nishihira,Yoshisato Shibata,Koichi Kaikita

    ESC Heart Failure   13 ( 2 )   2026.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press  

    BACKGROUND AND AIMS: Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) is now increasingly identified as a cause of heart failure in older adults. This study aimed to clarify the morphological and functional alterations of the left ventricle (LV) that define the early stage of this condition. METHODS: We prospectively evaluated 81 patients diagnosed with wild-type ATTR (ATTRwt) amyloidosis (mean age 77 ± 6 years; 88% male), categorized into three groups based on myocardial uptake on radioactive pyrophosphate scintigraphy and histological confirmation: (i) carpal ATTR without cardiac involvement (Group 1, n = 13), (ii) asymptomatic cardiac involvement (Group 2, n = 10) and (iii) overt heart failure (Group 3, n = 58). RESULTS: Compared with Group 3, Group 1 showed higher absolute global longitudinal strain (GLS) (median 19.0 [13.2-23.8]%, P < .001), a lower apical-sparing ratio (median 0.66 [0.55-1.04], P < .001) and lower brain natriuretic peptide (BNP) (median 13.5 [6-49] pg/mL, P < .001) and troponin-T concentrations (0.012 [0.006-0.022] ng/mL, P < .001), while the estimated glomerular filtration rate remained preserved (64 ± 9 mL/mL/1.73 m², P = .022). Segmental longitudinal strain (LS) differentiated Group 1 from Group 2, with basal inferoseptal LS significantly lower in patients with elevated troponin-T (> 0.014 ng/mL) than in those with lower values (13.9 ± 5.6% vs. 7.4 ± 1.8%, P = .046) in Group 1. A basal inferoseptal LS cutoff of 9.1% identified high troponin-T with an area under the curve (AUC) of 0.833 (P = .005), outperforming GLS (AUC 0.306, P = .217), BNP (AUC 0.667, P = .292), and LV ejection fraction (AUC 0.556, P = .743). CONCLUSIONS: Basal inferoseptal LS impairment may indicate early cardiac involvement in individuals with carpal tunnel syndrome carrying ATTRwt deposits.

    DOI: 10.1093/eschf/xvag055

    Scopus

    PubMed

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Books 【 display / non-display

  • バイスタンダーCPRの生命・機能予後に関する横断研究-宮崎市消防局管内で発生した心肺機能停止1,686年の解析-

    鶴田敏博、濱畑貴晃、遠藤穣治、海北幸一( Role: Joint author)

    宮崎県医師会  2023.10 

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    Language:Japanese Book type:Scholarly book

  • 人々を繋ぎ、宮崎県から世界へ~これからの東九州メディカルバレー構想と宮崎大学の医工連携事業 Reviewed

    鶴田敏博、平山麻美、小牧聡一、中村小夜子、宮田敬公、金子彰彦、福永千紗、岩本脩成、森田 徹、荒武 尚( Role: Joint author)

    宮崎県医師会  2023.3 

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    Responsible for pages:112-116   Language:Japanese Book type:Scholarly book

  • 宮崎大学学生の医療機器開発への関心についての調査

    平山麻美、鶴田敏博、小牧聡一、中村小夜子、宮田敬公、金子彰彦、福永千紗、岩本脩成、森田 徹、荒武 尚( Role: Joint author)

    宮崎県医師会  2023.3 

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    Language:Japanese Book type:Scholarly book

  • 腎保護薬update 可溶性グアニル酸シクラーゼ刺激薬

    鶴田敏博( Role: Sole author)

    東京医学社  2021.8 

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    Language:Japanese Book type:Scholarly book

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  • Current Therapy in Cardiovascular Diseases

    ( Role: Joint author)

    2020.1 

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    Total pages:3   Responsible for pages:295-297   Language:Japanese Book type:Scholarly book

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MISC 【 display / non-display

  • 心不全の基礎研究.心不全の分子機序.神経体液性因子.アドレノメデュリン Invited

    鶴田敏博、北村和雄

    日本臨床社   76 ( 9 )   136 - 143   2018

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 骨と心血管を巡る破骨細胞形成抑制因子、「オステオプロテゲリン」 Invited

    鶴田敏博、宇田川信之、北村和雄

    循環制御   39 ( 3 )   157 - 159   2018

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:日本循環制御学会  

  • What are the clinical consequences of hyperkalemia on the heart and what are the uses of electrocardiograms in hyperkalemia?

    Ideguchi T, Tsuruda T

    E-journal of Cardiology Practice   14   12   2016.6

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    Language:English   Publishing type:Research paper, summary (national, other academic conference)   Publisher:European society of cardiology  

  • Guanylate cyclase on renal protection; update

    Tsuruda T, Kitamura K

    Kidney and Dialysis   80 ( 4 )   556 - 560   2016.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:Tokyo-igakusha.co.jp  

  • ストローマからみた心血管病「序文」

    北村和雄、鶴田敏博

    循環器内科   74   123 - 124   2013.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:科学評論社  

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Presentations 【 display / non-display

  • 見逃さないATTR-CM、途切れさせない連携 宮崎での実践と最新データ Invited

    鶴田敏博

    第139回日本循環器学会九州地方会スイーツセミナー  2025.12.6 

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    Event date: 2025.12.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • Characterization of left ventricular 2-dimentional strain imaging in carpal tunnel syndrome associated with wild-type transthyretin amyloidosis International conference

    Toshihiro Tsuruda

    ESC Congress 2025 

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    Event date: 2025.8.29 - 2025.9.1

    Language:English   Presentation type:Oral presentation (general)  

  • 区域ストレイン解析からトランスサイレチン型心アミロイドーシスの病態を理解する

    鶴田敏博、田中美与、尾方美幸、海野光佑、伊藤芽生、海北幸一

    日本超音波医学会第98回学術集会  2025.5.30 

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    Event date: 2025.5.30 - 2025.6.1

    Presentation type:Oral presentation (general)  

  • Segmental Analysis of 2-dimensional Speckle-tracking Echocardiography in Clinical Spectrum of Transthyretin-derived Amyloid Cardiomyopathy.

    鶴田敏博

    第89回日本循環器学会学術集会  2025.3.30 

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    Event date: 2025.3.28 - 2025.3.30

    Presentation type:Poster presentation  

  • Basal inferior-septal segment is highly susceptible to deformation in the clinical spectrum of transthyretin-derived cardiomyopathy International conference

    鶴田敏博

    ESC Congress 2024  2024.8.31 

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    Event date: 2024.8.30 - 2024.9.2

    Language:English   Presentation type:Oral presentation (general)  

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Awards 【 display / non-display

  • 第38回医学賞

    2024.2   宮崎県医師会   バイスタンダーCPRの生命・機能予後に関する横断研究-宮崎市消防局管内で発生した心肺機能停止1,686件の解析-

    鶴田敏博

  • 第53回高血圧関連疾患モデル学会会長賞

    2017   高血圧関連疾患モデル学会  

    鶴田敏博

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 第120回日本循環器学会九州地方会トランスレーショナルリサーチセッション優秀賞

    2016.6   日本循環器学会九州支部  

    鶴田敏博

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • Best Poster in the Basic/ Translational Domain ACC Geriatric Cardiology Member Section

    2016.4   American College of Cardiology  

    Tsuruda T

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    Award type:Award from international society, conference, symposium, etc.  Country:United States

  • Best poster award (neurohormones) at European Society of Cardiology Congress

    2015.8   European Society of Cardiology  

    Tsuruda T

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    Award type:Award from international society, conference, symposium, etc.  Country:United Kingdom

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Grant-in-Aid for Scientific Research 【 display / non-display

  • 新生児スクリーニングを契機に発見される家系内ファブリー病症例のコホート研究

    Grant number:25K13371  2025.04 - 2028.03

    独立行政法人日本学術振興会  科学研究費基金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • 骨芽細胞のビタミンD受容体が制御するCa・P代謝異常フレイル様病態の責任分子同定

    Grant number:24K02618  2024.04 - 2028.03

    独立行政法人日本学術振興会  科学研究費基金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

  • ナトリウム利尿ペプチド(NPs)は心肥大を促進しうるか

    Grant number:23K07581  2023.04 - 2026.03

    独立行政法人日本学術振興会  科学研究費基金  基盤研究(C)

    加藤 丈司

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    Authorship:Coinvestigator(s) 

  • Role of Cardiac Troponin-T Expression in Cancer Tissues

    Grant number:22K08128  2022.04 - 2025.03

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    Authorship:Principal investigator 

  • 心不全・動脈瘤の発症/進展におけるオステオプロテゲリンの関与

    Grant number:26461076  2014.04 - 2017.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    心不全・動脈瘤の発症/進展におけるオステオプロテゲリンの関与

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