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Faculty of Medicine School of Medicine Department of Medicine of Pathophysiological Diagnosis and Therapy, Anesthesiology and Intensive Care |
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TUNEYOSHI Isao
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Degree 【 display / non-display 】
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博士（医学） ( 1996.3 鹿児島大学 )
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医学士 ( 1990.3 鹿児島大学 )
Papers 【 display / non-display 】
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Misidentification of medical devices with radiographic contrast functions os retained foreign bodies on postoperative radiographs: a report of twe cases. Reviewed
Shuji Uchimura, Toyoaki Maruta, Rintarou Kamada, Akiko Tomita, Isao Tsuneyoshi
Cureus 17 ( 1 ) 2025.1
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.7759/cureus.78154
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Maruta T., Kouroki S., Kurogi M., Hidaka K., Koshida T., Miura A., Nakagawa H., Yanagita T., Takeya R., Tsuneyoshi I.
Journal of Neuroscience Research 102 ( 10 ) 2024.10
Publishing type：Research paper (scientific journal) Publisher：Journal of Neuroscience Research
Voltage-gated sodium channels, including NaV1.7, NaV1.8, and NaV1.9, play important roles in pain transmission and chronic pain development. However, the specific mechanisms of their action remain unclear, highlighting the need for in vivo stimulation studies of these channels. Optogenetics, a novel technique for targeting the activation or inhibition of specific neural circuits using light, offers a promising solution. In our previous study, we used optogenetics to selectively excite NaV1.7-expressing neurons in the dorsal root ganglion of mice to induce nocifensive behavior. Here, we further characterize the impact of nocifensive behavior by activation of NaV1.7, NaV1.8, or NaV1.9-expressing neurons. Using CRISPR/Cas9-mediated homologous recombination, NaV1.7–iCre, NaV1.8–iCre, or NaV1.9–iCre mice expressing iCre recombinase under the control of the endogenous NaV1.7, NaV1.8, or NaV1.9 gene promoter were produced. These mice were then bred with channelrhodopsin-2 (ChR2) Cre–reporter Ai32 mice to obtain NaV1.7–ChR2, NaV1.8–ChR2, or NaV1.9–ChR2 mice. Blue light exposure triggered paw withdrawal in all mice, with the strongest response in NaV1.8–ChR2 mice. These light sensitivity differences observed across NaV1.x–ChR2 mice may be dependent on ChR2 expression or reflect the inherent disparities in their pain transmission roles. In conclusion, we have generated noninvasive pain models, with optically activated peripheral nociceptors. We believe that studies using optogenetics will further elucidate the role of sodium channel subtypes in pain transmission.
DOI： 10.1002/jnr.25386
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Effect of intravenous administration of hydroxyzine hydrochloride on intrathecal morphine-induced pruritus after cesarean section. Reviewed
Shuji Uchimura, Takeshi Yano, Isao Tsuneyoshi
Minerva anestesiologica 90 ( 3 ) 219 - 221 2024.3
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Measuring intraoperative anesthetic parameters during hepatectomy with inferior vena cava clamping Reviewed
Nanashima A., Hiyoshi M., Imamura N., Hamada T., Tsuchimochi Y., Shimizu I., Ota Y., Furukawa K., Tsuneyoshi I.
Langenbeck's Archives of Surgery 408 ( 1 ) 2023.12
Publishing type：Research paper (scientific journal) Publisher：Langenbeck's Archives of Surgery
Purpose: Uncontrollable bleeding remained problematic in anatomical hepatectomy exposing hepatic veins. Based on the inferior vena cava (IVC) anatomy, we attempted to analyze the hemodynamic and surgical effects of the combined IVC-partial clamp (PC) accompanied with the Trendelenburg position (TP). Methods: We prospectively assessed 26 consecutive patients who underwent anatomical hepatectomies exposing HV trunks between 2020 and 2023. Patients were divided into three groups: use of IVC-PC (group 1), no use of IVC-PC (group 2), and use of IVC-PC accompanied with TP (group 3). In 10 of 26 patients (38%), hepatic venous pressure was examined using transhepatic catheter insertion. Results: IVC-PC was performed in 15 patients (58%). Operating time and procedures did not significantly differ between groups. A direct hemostatic effect on hepatic veins was evaluated in 60% and 70% of patients in groups 1 and 3, respectively. Group 1 showed significantly more unstable vital status and vasopressor use (p < 0.01). Blood or fluid transfusion and urinary output were similar between groups. Group 2 had a significantly lower baseline central venous pressure (CVP), while group 3 showed a significant increase in CVP in TP. CVP under IVC-PC seemed lower than under TP; however, not significantly. Hepatic venous pressure did not significantly differ between groups. Systolic arterial blood pressure significantly decreased via IVC-PC in group 1 and to a similar extent in group 3. Heart rate significantly increased during IVC-PC (p < 0.05). Conclusion: IVC-PC combined with the TP may be an alternative procedure to control intrahepatic venous bleeding during anatomical hepatectomy exposing hepatic venous trunks.
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胸腺腫による心圧排所見を伴う発作性心房細動に対してランジオロールが奏効した1症例 Reviewed
興梠 聡志, 矢野 武志, 村社 瑞穂, 長嶺 佳弘, 古澤 高廣, 長濵 真澄, 與那覇 哲, 谷口 正彦, 恒吉 勇男
麻酔 72 ( 3 ) 285 - 290 2023.3
Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：克誠堂出版
Books 【 display / non-display 】
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麻酔科研修ノート（第４版）
恒吉勇男（ Role： Joint author , 麻酔法選択に関する考え方）
診断と治療社 2024.11
Responsible for pages：86-88 Language：Japanese Book type：Scholarly book
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臨床麻酔科学書
荒川英樹，恒吉勇男（ Role： Joint author , 術後早期離床・リハビリテーション）
中山書店 2022.7
Responsible for pages：712-714 Language：Japanese Book type：Scholarly book
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臨床麻酔科学書
山下幸貴，恒吉勇男（ Role： Joint author , 術後せん妄対策）
中山書店 2022.7
Responsible for pages：710-711 Language：Japanese Book type：Scholarly book
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臨床麻酔科学書
恒吉勇男（ Role： Joint author , 術後循環管理）
中山書店 2022.7
Responsible for pages：708-709 Language：Japanese Book type：Scholarly book
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臨床麻酔科学書
恒吉勇男（ Role： Joint author , 術後呼吸管理）
中山書店 2022.7
Responsible for pages：706-707 Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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Uchimura S., Yano T., Tsuneyoshi I.
Minerva Anestesiologica 90 ( 3 ) 219 - 221 2024.3
Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Minerva Anestesiologica
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挿管チューブ固定テープによる皮膚損傷について（Q＆A）． Invited Reviewed
村瀬玲子，山田高成、森崎 浩、恒吉勇男
臨床麻酔 43 ( 6 ) 881 - 884 2019.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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各歳人口構成による年間手術件数の解析．
指宿昌一郎，恒吉勇男
日本手術医学会誌 38 ( 1 ) 40 - 43 2017.2
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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デスフルランの上手な使い方 各科手術での使用：高齢者手術―高齢者への応用の長所・短所―．
矢野武志，恒吉勇男
日本臨床麻酔学会誌 36 ( 4 ) 479 - 483 2016.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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デスフルランの上手な使い方 各科手術での使用：頭頚部外科手術・眼科手術―眼内圧，咽頭喉頭筋群（SAS）への影響―
森 信一郎，恒吉勇男
日本臨床麻酔学会誌 36 ( 4 ) 460 - 463 2016.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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難治性後頭部痛に対して，大後頭神経へのパルス高周波法が有効であった一症例．
吉海瑞穂，日髙康太郎，渡部由美，山賀昌治，恒吉勇男
日本ペインクリニック学会第２回九州支部学術集会
Event date： 2022.2.28 - 2022.3.13
Language：Japanese Presentation type：Oral presentation (general)
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帯状疱疹後神経痛モデルラットにおける高周波パルス療法の作用機序の検討．
日髙康太郎，丸田豊明，越田智広，興梠聡志，白阪哲朗，恒吉勇男
第43回日本疼痛学会
Event date： 2021.12.10 - 2021.12.11
Language：Japanese Presentation type：Oral presentation (general)
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年齢のロクロニウムの作用発現時間と作用持続時間に及ぼす影響．
押川 隆，白阪哲朗，恒吉勇男
日本臨床麻酔学会第41回大会
Event date： 2021.11.5 - 2021.11.7
Language：Japanese Presentation type：Oral presentation (general)
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人工呼吸器HAMILTON-G5に内蔵された高流量酸素投与機能の使用経験．
村社瑞穂，長嶺佳弘，矢野武志，谷口正彦，恒吉勇男
日本臨床麻酔学会第41回大会
Event date： 2021.11.5 - 2021.11.7
Language：Japanese Presentation type：Oral presentation (general)
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腹臥位療法後にICU-acquired weaknessを発症した重症COVID-19の１症例．
古澤高廣，矢野武志，村社瑞穂，深尾麻由，與那覇 哲，山下幸貴，谷口正彦，恒吉勇男
日本臨床麻酔学会第41回大会
Event date： 2021.11.5 - 2021.11.7
Language：Japanese Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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ヒト臍帯動脈におけるmyogenic response の検討
Grant number：16K10943 2016.04 - 2019.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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ヒト血管の反応性；正常反応から病態変化に関する研究
Grant number：24592346 2012.04 - 2015.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
ヒト血管の反応性；正常反応から病態変化に関する研究
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麻酔ならびにショック時の血管反応性に関する研究
Grant number：21592018 2009.04 - 2012.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
麻酔ならびにショック時の血管反応性に関する研究
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ヒト血管平滑筋を用いた敗血症ならびに人工心肺時における血管反応性に関する研究
Grant number：17591644 2005.04 - 2008.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
ショック患者の血管および平滑筋細胞レベルでの内部環境の変化を理解し，その背後にある複雑な病態ネットワークを解明，解析する
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敗血症性ショックならびに多臓器不全時における血管反応性に関する研究
Grant number：14571453 2002.04 - 2004.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
ショック時における1）血管弛緩，収縮因子の発現状況および各因子間の相互作用，2）内因性ホルモンの分泌と循環動態との関連性，3）血管反応性低下のメカニズムを分析・解析し，血管反応性を回復させうる新しい治療法の研究・開発を勤めることを目的とした研究