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Affiliation |
Faculty of Medicine College Hospital Psychiatry department |
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Related SDGs |
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FUNAHASHI Hideki
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Degree 【 display / non-display 】
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博士（医） ( 2015.3 宮崎大学 )
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学士（医学） ( 2002.3 宮崎医科大学 )
Papers 【 display / non-display 】
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Role of orexin receptors in histamine- and chloroquine-induced pruriceptive processing Reviewed
Kanemaru-Kawazoe A., Funahashi H., Kogoh Y., Haruta-Tsukamoto A., Miyahara Y., Nishimori T., Ishida Y., Hirano Y.
Neuroscience Research 219 104952 2025.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Neuroscience Research
It is known that orexin peptides are involved in nociceptive processing, while little is known about the roles of these peptides in itch processing. To reveal the functions of orexin peptides in pruriceptive processing, orexin A (OX-A) and orexin B (OX-B) were applied before histamine or chloroquine (CQ). The administration of OX-A reduced the numbers of scratching events and c-Fos positive cells induced by histamine and CQ, but not OX-B. To clarify the involvement of orexin receptors in pruriceptive processing, OX-A was administered after the injection of an orexin receptor type 1 (OX<inf>1</inf>) antagonist (SB334867) or an orexin receptor type 2 (OX<inf>2</inf>) antagonist (JNJ10397049) before histamine and CQ injections. The attenuating effects of OX-A on histamine- and CQ-induced scratching events were reversed by JNJ1039 and SB334867, respectively. To confirm the role of OX<inf>2</inf> receptor, an OX<inf>2</inf> receptor agonist (YNT185) was applied before the injection of histamine or CQ. Scratching events and c-Fos expression induced by histamine, but not CQ, were attenuated by the pretreatment with YNT185. These results indicate that OX-A elicits the attenuating effects in pruriceptive processing and that itch signals induced by histamine and CQ appear to be differentially regulated by the OX<inf>2</inf> receptors and OX<inf>1</inf> receptors.
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Role of orexin receptors in histamine- and chloroquine-induced pruriceptive processing Reviewed
金丸 杏奈, 船橋 英樹, 古郷 央一郎, 西森 利數, 平野 羊嗣
Neuroscience Research 219 104952 2025.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Ireland Ltd
It is known that orexin peptides are involved in nociceptive processing, while little is known about the roles of these peptides in itch processing. To reveal the functions of orexin peptides in pruriceptive processing, orexin A (OX-A) and orexin B (OX-B) were applied before histamine or chloroquine (CQ). The administration of OX-A reduced the numbers of scratching events and c-Fos positive cells induced by histamine and CQ, but not OX-B. To clarify the involvement of orexin receptors in pruriceptive processing, OX-A was administered after the injection of an orexin receptor type 1 (OX1) antagonist (SB334867) or an orexin receptor type 2 (OX2) antagonist (JNJ10397049) before histamine and CQ injections. The attenuating effects of OX-A on histamine- and CQ-induced scratching events were reversed by JNJ1039 and SB334867, respectively. To confirm the role of OX2 receptor, an OX2 receptor agonist (YNT185) was applied before the injection of histamine or CQ. Scratching events and c-Fos expression induced by histamine, but not CQ, were attenuated by the pretreatment with YNT185. These results indicate that OX-A elicits the attenuating effects in pruriceptive processing and that itch signals induced by histamine and CQ appear to be differentially regulated by the OX2 receptors and OX1 receptors.
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Development of a questionnaire for evaluating supporters’ skills in Hikikomori support Reviewed
Kubo H., Naono-Nagatomo K., Sakai M., Nonaka S., Funahashi H., Ishida Y., Hirano Y.
Current Psychology 44 ( 14 ) 13203 - 13221 2025.7
Publishing type：Research paper (scientific journal) Publisher：Current Psychology
Enhancing the skills of hikikomori supporters inherently contributes to improving the quality of support provided. However, a comprehensive skills assessment tool for these supporters has not yet been developed. This study aimed to develop a self-rated questionnaire, the Hikikomori Supporter’s Skills Checklist (HSSC). Based on a preliminary survey involving 43 supporters, the HSSC draft was revised. The revised version comprises 39 items addressing various aspects of consultation support. In the main survey, questionnaires were posted to 118 hikikomori community support centers. To assess convergent and discriminant validity and derive clinical insights, respondents completed the HSSC along with measures of stigmatic attitudes toward hikikomori and psychiatric patients, workplace psychological flexibility, burnout, and demographics, including prior experience in hikikomori-related learning and support. Analysis of 238 valid responses revealed a single-factor structure; however, 12 items were removed due to lower item factor loadings. The refined 27-item HSSC demonstrated acceptable internal consistency (Cronbach’s α = 0.74). HSSC scores showed a significant correlation with the number of training sessions undertaken (ρ = 0.24), along with other theoretically consistent but statistically non-significant correlations, supporting the checklist’s validity. Furthermore, in the comparison involving specific questions with relatively low correct response rate, a linear increase in the total HSSC score was observed across the low-, middle-, and high correct response rate groups. However, score distribution deviated from normality due to limited data from lower-scoring participants, restricting parametric analysis. Although further validation is necessary, the HSSC appears valuable for promoting self-reflection among hikikomori supporters and evaluating training outcomes.
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Development of a questionnaire for evaluating supporters’ skills in Hikikomori support Reviewed
久保 浩明, 境 泉洋, 船橋 英樹, 石田 康, 平野 羊嗣
Current Psychology 44 ( 14 ) 13203 - 13221 2025.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Nature
Enhancing the skills of hikikomori supporters inherently contributes to improving the quality of support provided. However, a comprehensive skills assessment tool for these supporters has not yet been developed. This study aimed to develop a self-rated questionnaire, the Hikikomori Supporter’s Skills Checklist (HSSC). Based on a preliminary survey involving 43 supporters, the HSSC draft was revised. The revised version comprises 39 items addressing various aspects of consultation support. In the main survey, questionnaires were posted to 118 hikikomori community support centers. To assess convergent and discriminant validity and derive clinical insights, respondents completed the HSSC along with measures of stigmatic attitudes toward hikikomori and psychiatric patients, workplace psychological flexibility, burnout, and demographics, including prior experience in hikikomori-related learning and support. Analysis of 238 valid responses revealed a single-factor structure
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「嘘」を直面化した際に異なる反応を示した4症例 Invited
船橋英樹，藤元貴子，津曲麻依，鶴田健二，中尾周平，山下真由子，久保浩明，平野羊嗣，石田康
九州神経精神医学誌 69 ( 2 ) 101 - 107 2024.4
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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がん患者の精神症状はこう診る 向精神薬はこう使う
上村恵一,小川朝生,谷向仁,船橋英樹（ Role： Joint editor , 第2章 3．せん妄）
じほう 2015.6
Language：Japanese Book type：Scholarly book
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がん患者の精神症状はこう診る向精神薬はこう使う : 精神腫瘍医のアプローチが25のケースでわかる
上村 恵一, 小川 朝生, 谷向 仁, 船橋 英樹
じほう 2015
Language：Japanese
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うつ病治療のエクセレンス〜ミルナシプランの治療経験からみえてくるもの
石田康，武田龍一郎，安部博史，松尾寿栄，蛯原功介，船橋英樹，池田哲也，西森利數（ Role： Joint author , 81−84）
アルタ出版 2010.12
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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「嘘」を直面化した際に異なる反応を示した4症例 Invited Reviewed
船橋英樹*, 藤元貴子, 津曲麻依, 鶴田健二, 中尾周平, 山下真由子, 久保浩明, 平野羊嗣, 石田康
九州神経精神医学誌 69 101 - 107 2024.4
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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出産を契機に人格統合に至った解離性同一性障害の1症例 Reviewed
船橋英樹*, 金丸杏奈, 石本明実, 後田眞樹, 山下真由子, 吉田佳奈, 中尾周平, 山口朋音, 橘紗稀, 小佐井昌人, 久保浩明, 石田康
宮崎県医師会医学会誌 68 9 - 14 2022.9
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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がん患者にみられる通常の心理反応と精神疾患 怒りや否認へのアプローチ
船橋英樹
薬事 55 ( 12 ) 2190 - 2194 2013.11
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：じほう
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宮崎県内の緩和ケア普及への取り組み
船橋英樹、國枝良行
宮崎市郡医師会会報「一語一話」 ( 63 ) 10 - 11 2011.2
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other) Publisher：宮崎市郡医師会
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研修セミナー精神腫瘍医コースを終えて
船橋英樹
日本サイコオンコロジーニューズレター ( 63 ) 10 - 11 2010.11
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other) Publisher：日本サイコオンコロジー学会
Presentations 【 display / non-display 】
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A Mast cell stabilizer suppresses the induction of scratching behavior by subcutaneous administration of SP or HK-1
Japan Pain Week 2025.12.5
Event date： 2025.12.4 - 2025.12.6
Language：Japanese Presentation type：Poster presentation
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Exploring the Therapeutic Potential of Endokinin Peptides: A Promising Lead Compound for Anti-Inflammatory Drugs
Japan Pain Week 2025.12.5
Event date： 2025.12.4 - 2025.12.6
Language：Japanese Presentation type：Poster presentation
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A mast cell stabilizer reduced the induction of scratching behavior by subcutaneous administration of SP or HK-1 International conference
Funahashi H, Kogoh Y, Kanemaru-Kawazoe A, Uchida H, Haruta-Tsukamoto A, Miyahara Y, Hirano Y, Nishimori T, Ishida Y
12th World Congress on Itch 2023.11.5
Event date： 2023.11.4 - 2023.11.7
Language：English Presentation type：Poster presentation
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Role of PBN projecting CeApdyn amygdala neurons in nociception International coauthorship International conference
Funahashi H, Pavlenko D, Sakai K, Akiyama T
Sfn Global Connectome 2021.1
Event date： 2021.1.12
Language：English Presentation type：Oral presentation (general)
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Effect of [Leu11]-HK-1-derived peptides on scratching behavior in mice with chronic itch International conference
Funahashi H, Miyahara Y, Haruta-Tsukamoto A, Naono-Nakayama R, Nishimori T, Ishida Y
9th World Congress on Itch 2017.11
Event date： 2017.11.3 - 2017.11.5
Language：English Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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第6回DPA研究会
2010.1 第6回DPA研究会
船橋英樹, 武田龍一郎, 長友慶子, 松尾寿栄, 安部博史, 石田 康
Award type：Award from international society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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パーキンソン病モデルラットのアロディニアに関連した線条体アストロサイトの機能解析
Grant number：21K07503 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
石田 康
Authorship：Coinvestigator(s)
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痒みの伝達におけるヘモキニン-1の役割に関する研究
Grant number：26870451 2014.04 - 2016.03
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
痒みの伝達におけるヘモキニン-1の役割に関する研究