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Faculty of Medicine College Hospital Psychiatry department |
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FUNAHASHI Hideki
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Degree 【 display / non-display 】
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博士（医） ( 2015.3 宮崎大学 )
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学士（医学） ( 2002.3 宮崎医科大学 )
Papers 【 display / non-display 】
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Role of kainate receptors in pruriceptive processing in the mouse spinal cord Reviewed
Haruta-Tsukamoto A., Kanemaru-Kawazoe A., Kogoh Y., Miyahara Y., Funahashi H., Hirano Y., Nishimori T., Ishida Y.
European Journal of Pharmacology 957 175998 2023.10
Language：English Publishing type：Research paper (scientific journal) Publisher：European Journal of Pharmacology
Pruritus, including neuropathic and psychogenic pruritus, is an unpleasant feeling that causes a desire to scratch, which negatively impacts physical and psychological aspects of daily life. Nonetheless, little is known about the neural mechanisms involved in pruritus. Glutamate is a predominant excitatory neurotransmitter in the mammalian central nervous system and exerts its effects by binding to various glutamate receptors, including kainate (KA) receptors; however, the precise involvement of each glutamate receptor in pruriceptive processing remains unclear, particularly that of KA receptors. Therefore, the roles of KA receptors in histamine-dependent and -independent itch were investigated using CNQX, an AMPA/KA receptors antagonist, UBP310 and UBP302, antagonists of KA receptors, and small interfering (si)RNAs against KA receptor subunits in mice with acute and chronic pruritus. The effects of KA receptor antagonists on histamine-induced c-Fos expression in the spinal cord were also examined. The intrathecal administration of CNQX reduced the number of scratching events induced by histamine and chloroquine. On the other hand, UBP310 or UBP302 and the siRNAs of KA receptor subunits 1–3 significantly inhibited the induction of scratching events in mice treated with histamine, while no significant change was observed in the induction of spontaneous scratching events in mice with chronic pruritus. In addition, antagonists of KA receptors attenuated c-Fos expression in the superficial layers of the dorsal horn induced by histamine. These results indicate that KA receptors are involved in acute pruriceptive processing in the spinal cord induced by histamine, but not chloroquine or chronic itch.
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Dynorphinergic Projections from the Central Amygdala to the Parabrachial Nucleus Regulate Itch Reviewed
Funahashi H., Pavlenko D., Sakai K., Verpile R., Sanders K.M., Akiyama T.
Journal of Neuroscience 43 ( 29 ) 5340 - 5349 2023.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Neuroscience
The amygdala plays a key role in the processing of itch and pain signals as well as emotion. A previous study revealed that the central nucleus of the amygdala (CeA)-parabrachial nucleus (PBN) pathway is involved in pain regulation. The same pathway might also control itch. To test this possibility, prodynorphin (Pdyn)-Cre mice were used to optogenetically manipulate Pdyn1 CeA-to-PBN projections. We found that optogenetic stimulation of Pdyn1 amygdala neurons or Pdyn1 CeA-to-PBN projections inhibited histamine-evoked and chloroquine-evoked scratching. The number of Fos-positive neurons in the PBN increased following intradermal injection of chloroquine. Optogenetic stimulation of Pdyn1 CeA-to-PBN projections suppressed the increase in Fos expression in the PBN. Optogenetic stimulation of Pdyn1 CeA-to-PBN projections increased thermal and mechanical thresholds without affecting anxiety-like behavior. These results highlight the importance of dynorphinergic projections from the central amygdala to the parabrachial nucleus in the regulation of itch signaling.
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Tsurue A., Funahashi H., Tsurue K., Kawano M., Ishida Y., Hirano Y.
Neuropsychopharmacology Reports 43 ( 2 ) 272 - 276 2023.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Neuropsychopharmacology Reports
Background: The optimal treatment strategy for patients with treatment-resistant schizophrenia (TRS) associated with 22q11.2 deletion syndrome (DS) remains a subject of debate. Case Presentation: We present the case of a 40-year-old female patient diagnosed with TRS and 22q11.2DS who was effectively treated with clozapine. She was diagnosed with schizophrenia and mild intellectual disability during her adolescence; despite being hospitalized for a period of 10 years beginning in her 30s, she continued to exhibit symptoms of impulsivity, and explosive behavior, requiring periods of isolation. We ultimately decided to switch her medication to clozapine, which was administered with caution and gradually titrated upward, with no discernable adverse effects, resulting in a marked improvement in her symptoms and obviated the need for isolation. Subsequently, the patient's history of congenital heart disease and facial abnormalities prompted initial suspicions of a 22q11.2DS diagnosis, which was subsequently confirmed through genetic testing. Conclusion: Clozapine may serve as an efficacious pharmacological intervention for TRS patients with 22q11.2DS, including those of Asian descent.
DOI： 10.1002/npr2.12333
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Haruta Tomotaka, Ishimoto Akemi, Haruta-Tsukamoto Ayaka, Funahashi Hideki, Ishida Yasushi
Kyushu Neuropsychiatry 68 ( 2 ) 47 - 52 2023.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Association of Kyushu Neuropsychiatry
We encountered a case in which a combination of venlafaxine and cognitive behavioral therapy alleviated intractable trigeminal neuralgia. The patient was a 72-year-old woman. Despite treatment for trigeminal neuralgia with various types of medications, nerve blocks, and neurovascular decompression, she reported pain that repeatedly flared up. The patient was transferred to our department and received treatment with a combination of venlafaxine and cognitive behavioral therapy. As a result,the pain was alleviated. Chronic pain tends to be intractable due to physical and psychosocial factors; thus, it is important to combine pharmacotherapy and non-pharmacotherapy to achieve effective treatment. Venlafaxine has no indications for pain in Japan; however, it may be efficacious for treating chronic pain.
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Okahara K., Ohsawa M., Haruta-Tsukamoto A., Miyoshi R., Funahashi H., Fukutani Y., Makita S., Matsuo H., Ishida Y., Numomura A.
Journal of Alzheimer's Disease Reports 7 ( 1 ) 107 - 117 2023
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Alzheimer's Disease Reports
Background: Alzheimer's disease (AD) and dementia have increasingly been conceived of as 'complex diseases of aging', determined by multiple, simultaneous, interacting pathophysiological processes. The condition known as frailty is a phenotype of aging and its comprehensive pathophysiology is thought to be closely related to the incidence of mild cognitive impairment (MCI) and the exacerbation of dementia. Objective: This study aimed to investigate the effect of the multicomponent drug, ninjin'yoeito (NYT), on frailty in MCI and mild AD patients. Methods: This study was an open-label trial. A total of 14 patients, including 9 with MCI and 5 with mild AD, were enrolled. Among them, 11 were frail while 3 were prefrail. NYT (6-9 g/day) was administered orally for 24 weeks, and assessments were carried out at baseline (week 0), and at 4, 8, 16, and 24 weeks. Results: In the primary endpoint, significant early improvements were observed in the anorexia scores according to the Neuropsychiatric Inventory after four weeks of treatment with NYT. The Cardiovascular Health Study score was significantly improved, and no frailty was observed after 24 weeks. The fatigue visual analog scale scores also significantly improved. The Clinical Dementia Rating and the Montreal Cognitive Assessment scores remained at baseline levels during the NYT treatment period. Conclusion: The results suggest that NYT may be effective in the treatment of frailty, especially for anorexia and fatigue, in both MCI and mild AD patients, which would be beneficial for the prognosis of dementia.
DOI： 10.3233/ADR-220074
Books 【 display / non-display 】
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がん患者の精神症状はこう診る 向精神薬はこう使う
上村恵一,小川朝生,谷向仁,船橋英樹（ Role： Joint editor , 第2章 3．せん妄）
じほう 2015.6
Language：Japanese Book type：Scholarly book
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がん患者の精神症状はこう診る向精神薬はこう使う : 精神腫瘍医のアプローチが25のケースでわかる
上村 恵一, 小川 朝生, 谷向 仁, 船橋 英樹
じほう 2015
Language：Japanese
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うつ病治療のエクセレンス〜ミルナシプランの治療経験からみえてくるもの
石田康，武田龍一郎，安部博史，松尾寿栄，蛯原功介，船橋英樹，池田哲也，西森利數（ Role： Joint author , 81−84）
アルタ出版 2010.12
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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がん患者にみられる通常の心理反応と精神疾患 怒りや否認へのアプローチ
船橋英樹
薬事 55 ( 12 ) 2190 - 2194 2013.11
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：じほう
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宮崎県内の緩和ケア普及への取り組み
船橋英樹、國枝良行
宮崎市郡医師会会報「一語一話」 ( 63 ) 10 - 11 2011.2
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other) Publisher：宮崎市郡医師会
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研修セミナー精神腫瘍医コースを終えて
船橋英樹
日本サイコオンコロジーニューズレター ( 63 ) 10 - 11 2010.11
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other) Publisher：日本サイコオンコロジー学会
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虚偽性障害の妊婦の１症例
船橋英樹 、松尾寿栄、長友慶子、武田龍一郎、瀬戸雄飛、山田直史、山内憲之、木許恭宏、石田康
宮崎県医師会医学会誌 34 ( 1 ) 67 - 71 2010.7
Language：Japanese Publishing type：Research paper, summary (national, other academic conference) Publisher：宮崎県医師会
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疼痛治療における抗うつ薬の役割
石田康, 武田龍一郎, 船橋英樹
精神神経学雑誌 112 ( 6 ) 622 - 624 2010.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other) Publisher：日本精神神経学会
Presentations 【 display / non-display 】
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Intranasal administration of [ Leu11] -HK-1-derived peptides has the antipruriceptive effect in rats
Intranasal administration of [ Leu11] -HK-1-derived peptides has the antipruriceptive effect in rats
日本生物学的精神医学会 (福岡県福岡市) 日本生物学的精神医学会
Event date： 2016.9.9
Language：English Presentation type：Poster presentation
Venue：福岡県福岡市
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脊髄におけるオーファン受容体GPR83は痒み伝達機構に関与する
中山-直野留美、船橋英樹、西森利數、高宮考悟
第42 回日本脳科学会 (宮崎県宮崎市) 第42 回日本脳科学会
Event date： 2015.11.13
Language：English Presentation type：Oral presentation (general)
Venue：宮崎県宮崎市
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ラットの三叉神経節および三叉神経感覚核におけるサブスタンスPおよびヘモキニン-1の分布 International conference
井川加織、西森利數、船橋英樹、宮原裕、松尾寿栄、石田康
第42回日本脳科学会 (宮崎県宮崎市) 第42回日本脳科学会
Event date： 2015.11.13
Language：Japanese Presentation type：Oral presentation (general)
Venue：宮崎県宮崎市
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[ Leu11] -HK-1-derived peptides with D-Trp have the prolonged antipruriceptive effects in rats. International conference
Hideki Funahashi, Rumi Naono-Nakayama, Yu Miyahara, Toshikazu Nishimori, Yasushi Ishida
8th World Congress of Itch (Nara, Japan) World Congress of Itch
Event date： 2015.9.27
Language：English Presentation type：Poster presentation
Venue：Nara, Japan
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虚言への直面化に異なる反応を示す3症例の診断的検討
船橋英樹、倉増亜紀、小金丸剛、松尾寿栄、武田龍一郎、安部博史、石田康
第32回日本精神科診断学会 (沖縄県宜野湾市) 日本精神科診断学会
Event date： 2012.11.22 - 2012.11.23
Language：Japanese Presentation type：Poster presentation
Venue：沖縄県宜野湾市
Awards 【 display / non-display 】
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第6回DPA研究会
2010.1 第6回DPA研究会
船橋英樹, 武田龍一郎, 長友慶子, 松尾寿栄, 安部博史, 石田 康
Award type：Award from international society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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パーキンソン病モデルラットのアロディニアに関連した線条体アストロサイトの機能解析
Grant number：21K07503 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
石田 康
Authorship：Coinvestigator(s)
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痒みの伝達におけるヘモキニン-1の役割に関する研究
2014.04 - 2016.03
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
痒みの伝達におけるヘモキニン-1の役割に関する研究