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Affiliation |
Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Urology |
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Associate Professor |
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External Link |
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MUKAI Shoichiro
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Papers 【 display / non-display 】
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Serum IgG4 Concentration Is a Potential Predictive Biomarker in Glucocorticoid Treatment for Idiopathic Retroperitoneal Fibrosis. Reviewed
向井尚一郎 賀本敏行
J Clin Med 2022.6
Authorship：Lead author Publishing type：Research paper (scientific journal)
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En bloc removal of a large leiomyosarcoma arising from the inferior vena cava using retroperitoneal laparoscopic dissection of posterior vessels followed by cavectomy in a thoracoabdominal approach. Reviewed
Kida K, Terada N, Nakamura E, Mukai S, Nanashima A, Kamoto T
Urology Case Reports 2019.9
Language：English Publishing type：Research paper (scientific journal)
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Feasibility of laparoscopic adrenalectomy for metastatic adrenal tumors in selected patients: a retrospective multicenter study of Japanese populations. Reviewed
Goto T, Inoue T, Kobayashi T, Yamasaki T, Ishitoya S, Segawa T, Ito N, Shichiri Y, Okumura K, Okuno H, Kawakita M, Kanaoka T, Terada N, Mukai S, Sugi M, Kinoshita H, Kamoto T, Matsuda T, Ogawa O.
Intetnational Journal of Clinical Oncology 2019.8
Language：English Publishing type：Research paper (scientific journal)
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Expression of protease activating receptor-2 (PAR-2) is positively correlated with the recurrence of non-muscle invasive bladder cancer: an immunohistochemical analysis. Reviewed
Nakahara K, Yamasaki K, Nagai T, Fujii M, Akioka T, Takamori H, Terada N, Mukai S, Sato Y, Kamoto T.
Res Rep Urol. 2019.4
Language：English Publishing type：Research paper (scientific journal)
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Terada N., Kamoto T., Tsukino H., Mukai S., Akamatsu S., Inoue T., Ogawa O., Narita S., Habuchi T., Yamashita S., Mitsuzuka K., Arai Y., Kandori S., Kojima T., Nishiyama H., Kawamura Y., Shimizu Y., Terachi T., Sugi M., Kinoshita H., Matsuda T., Yamada Y., Yamamoto S., Hirama H., Sugimoto M., Kakehi Y., Sakurai T., Tsuchiya N.
BMC cancer 19 ( 1 ) 2019.3
Language：English Publishing type：Research paper (scientific journal) Publisher：BMC cancer
BACKGROUND: We analyzed the efficacy and toxicity of cabazitaxel (CBZ) at high and low initial doses in Japanese patients with docetaxel-resistant castration-resistant prostate cancer (CRPC). METHODS: We retrospectively evaluated 118 patients who received CBZ for docetaxel-resistant CRPC in 10 university hospitals in Japan between 2014 and 2016. The rate of decrease of prostate-specific antigen (PSA), adverse events, progression-free survival (PFS), and overall survival (OS) were compared between patients receiving initially high (≥22.5 mg/m2, n = 36) and low (≤20 mg/m2, n = 80) CBZ doses. Factors associated with survival and grade 4 neutropenia were evaluated. RESULTS: PSA values decreased by > 50% in 22 patients (19%), with a higher frequency in the high-dose group than in the low-dose group (29 and 14%, P = 0.073). The median PFS time for the all-patient, high- and low-dose groups was 2.8 months (95% confidence interval [CI] 1.9-4.4), 2.1 months (1.2-5.5), and 3.0 months (2.0-4.4), respectively (P = 0.904). The median OS times were 16.3 months (95% CI 9.7-30.9), 30.9 months (11.8-47.4), and 10.2 months (8.6-20), respectively (P = 0.020). In multivariate analyses, PFS was significantly associated with existing bone metastasis at diagnosis (P = 0.005) and OS with PSA > 100 ng/ml (P = 0.007), hemoglobin < 12 g/dl (P = 0.030), and low initial CBZ dose (P = 0.030). Grade 4 neutropenia occurred in 53 patients (45%) and was associated with a low CBZ dose (hazard ratio 0.21, 95% CI 0.08-0.59, P = 0.002). CONCLUSIONS: CBZ at a higher initial dose may have similar response rate and response duration, but longer survival duration after treatment with higher toxicity than a lower initial dose for docetaxel-resistant CRPC in Japanese patients.
Books 【 display / non-display 】
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術式の選択基準と周術期アセスメント1．副腎腫瘍 泌尿器Care & Cure Uro-Lo
向井尚一郎（ Role： Sole author）
メディカ出版 2019
Language：Japanese
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Urologic Surgery Next１腹腔鏡手術 Ⅳ前立腺・膀胱の手術「腹腔鏡下前立腺全摘除術」
向井尚一郎，髙森大樹，賀本敏行（ Role： Joint author）
メジカルビュー社 2018
Language：Japanese Book type：Textbook, survey, introduction
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Urologic Surgery Next１腹腔鏡手術 Ⅳ前立腺・膀胱の手術「腹腔鏡下前立腺全摘除術」
向井尚一郎，髙森大樹，賀本敏行（ Role： Joint author）
メジカルビュー社 2018
Language：Japanese Book type：Textbook, survey, introduction
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精巣癌の治療 3. (2) 救済化学療法 日本臨床
向井尚一郎（ Role： Sole author）
日本臨床社 2017
Language：Japanese
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精巣癌の治療 3. (2) 救済化学療法 日本臨床
向井尚一郎（ Role： Sole author）
日本臨床社 2017
Language：Japanese
MISC 【 display / non-display 】
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前立腺がんの放射線療法（外照射、内照射）ってどんな治療法？
向井尚一郎
泌尿器care&cure Uro-Lo 21 ( 1 ) 41 - 44 2016.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：メディカ出版
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がん微小環境におけるtype Ⅱ transmembrane serine protease (TTSP) の働きについて (肝細胞増殖因子の活性化酵素とその制御機構を中心に)
向井尚一郎、月野浩昌
西日本泌尿器科 77 ( 10 ) 365 - 373 2015.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：西日本泌尿器科
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Laparoscopic anterior pelvic exenteration for locoregionally advanced rectal cancer directly invading the urinary bladder: A case report of low anterior resection with en bloc cystectomy for sphincter preservation.
石崎秀信、向井尚一郎他
Asian J Endosc Surg 2015.8
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Wiley Online Library
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RCCにおける分子標的治療の総括
向井尚一郎、賀本敏行
西日本泌尿器科 77 ( 4 ) 115 - 123 2015.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：西日本泌尿器科
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下大静脈塞栓を伴う腎細胞癌に対する手術戦略（症例検討会）
北悠希、向井尚一郎、賀本敏行
宮崎県医師会医学雑誌 38 ( 1 ) 49 - 52 2014.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other) Publisher：宮崎県医師会
Presentations 【 display / non-display 】
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大きな褐色細胞腫, 後腹膜腫瘍へのアプローチ～腹腔鏡の利用について
向井尚一郎
第32回日本泌尿器内視鏡学会総会
Event date： 2018.11.27 - 2018.11.29
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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ロボット時代の若手教育 標準術式の習得について
向井尚一郎
第106回日本泌尿器科学会総会
Event date： 2018.4.19 - 2018.4.22
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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骨盤内蔵全摘における泌尿器科の関わりについて
向井尚一郎，武田将司，賀本敏行，西田卓弘，河野文彰，池田拓人，七島篤志，石崎秀信，魏峻洸
第30回日本内視鏡外科学会総会
Event date： 2017.12.7 - 2017.12.9
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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超高齢時代のCRPC患者に対する骨マネジメントについて
向井尚一郎，藤井将人，月野浩昌，賀本敏行
第69回西日本泌尿器科学会
Event date： 2017.11.9 - 2017.11.12
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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HAI-2 regulates the growth of RCC cells in bone metastasis through suppression of matripatese International conference
Mukai S
The 34th Korea –Japan Urological Congress
Event date： 2017.10.23
Language：Japanese
Grant-in-Aid for Scientific Research 【 display / non-display 】
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ヒト化マウスを用いた腎細胞癌PDXモデルの樹立とMET阻害薬効果予測因子の同定
Grant number：22K09506 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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腎癌骨転移における膜結合型タンパクの機能解析と新規治療法の確立
2015.04 - 2018.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
腎癌骨転移における膜結合型タンパクの機能解析と新規治療法の確立