MARUTA Toyoaki



Faculty of Medicine College Hospital Anesthesiology



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Degree 【 display / non-display

  • 医学博士 ( 2008.3   宮崎大学 )

Research Areas 【 display / non-display

  • Life Science / Anesthesiology


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  • The usefulness of plasma levels of mature and total adrenomedullin as biomarkers indicating the magnitude of surgical stress responses: A single-center, prospective, observational study. International journal

    Go Otao, Toyoaki Maruta, Tetsu Yonaha, Koji Igarashi, Sayaka Nagata, Kazuo Kitamura, Isao Tsuneyoshi

    Journal of clinical and translational research   7 ( 3 )   302 - 310   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    Background and Aim: Adrenomedullin (AM), a vasodilatory peptide, is known for its pleiotropic actions. AM levels are increased under inflammatory conditions such as sepsis and can be useful as a prognostic biomarker. However, there are only a few reports on the physiological actions of AM in the perioperative period. The aim of this single-center, prospective, and observational study was to investigate the changes in the plasma levels of mature AM (mAM) and total AM (tAM) observed during the perioperative period. In addition, we aimed to determine the association between each AM level and immune-inflammatory parameters to explore the usefulness of AM as a biomarker of the magnitude of surgical stress responses. Methods: The levels of both mAM and tAM, in addition to the levels of presepsin, interleukin-6, procalcitonin, white blood cell, and C-reactive protein, were measured in blood samples obtained during the perioperative period. Other laboratory data, including sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation (APACHE) II scores, were obtained from individual clinical records. Correlations between each AM and clinical parameters were determined using Spearman's rank correlation. P<0.05 were considered statistically significant. Results: One hundred and twenty-three perioperative patients scheduled for three types of surgical procedures, including cardiopulmonary bypass surgery, abdominal surgery, and cervical laminoplasty, were included in this study. There was a moderate to strong correlation between each AM and immune-inflammatory parameters, SOFA score, and APACHE II score, as related to surgical trauma. Specifically, the strongest correlation was observed between each AM and SOFA score. Conclusions: These findings suggest that plasma AM levels may represent the most important inflammatory mediators that are evident in surgical stress responses. Relevance for patients: Since the levels of both tAM and mAM show the same trend, mAM and tAM may be equally used as biomarkers for the evaluation of the physiological status of surgical patients. Trial Registration: This observational study was retrospectively registered with Japanese Clinical Trial Registry "UMIN-CTR" on March 19, 2018, and was given a trial ID number UMIN000031792.



  • Comparison of opioid local anesthetic combination regimens using the number of self-administrated boluses in patient-controlled epidural analgesia after cesarean section A retrospective single-center study International journal

    Go Otao, Toyoaki Maruta, Isao Tsuneyoshi

    MEDICINE   100 ( 17 )   e25560   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    The aim of this study was to assess the efficacy of combined opioids by comparing four regimens of patient-controlled epidural analgesia (PCEA) after cesarean section. Parturient patients who underwent elective or emergent cesarean section under combined spinal and epidural anesthesia from April 2013 to March 2016 were retrospectively analyzed. Based on PCEA, they were assigned to one of 4 groups: local anesthetic alone (LA), epidural single morphine administration during surgery followed by local anesthetic alone (M), local anesthetic combined with fentanyl 10 mu g/h (F10), or local anesthetic combined with fentanyl 20 mu g/h (F20). The primary outcome was the number of PCEA boluses used. Secondary outcomes included the use of rescue analgesia, postoperative nausea and vomiting, and postoperative pruritus. A total of 250 parturients were analyzed. Whereas the number of PCEA boluses in the LA group was significantly higher than in the other combined opioid groups on the day of surgery and postoperative day 1 (LA: 3 [1-6] and 7 [4-9] vs M: 2 [0-4] and 4 [0-7] vs F10: 1 [0-4] and 3 [0-6] vs F20: 1 [0-3] and 2 [0-8], P = .012 and 0.010, respectively), within the combined opioid groups, the number was not significantly different. Significantly fewer patients in the F20 group required rescue analgesia on postoperative day 1 and 2 (25 and 55%) than those in the M (66 and 81%) and F10 (62 and 66%) groups (P P = .007, respectively). Postoperative nausea and vomiting and pruritus were significantly higher in the M group (P P = .024, respectively). The results of the present study suggest that local anesthetic alone after a single administration of morphine, or local anesthetic combined with fentanyl 10 mu g/h would generally be adequate for PCEA, whereas local anesthetic combined with fentanyl 20 mu g/h would be suitable for conventional epidural analgesia.

    DOI: 10.1097/MD.0000000000025560

    Web of Science




  • 全身麻酔前後での握力の回復率は術後残存筋弛緩の予測となりえるか. Reviewed


    麻酔   69 ( 8 )   851 - 854   2020.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • がん薬物療法が引き起こす末梢神経障害のエビデンス. Reviewed

    丸田豊明,丸田 望,柳田俊彦,恒吉勇男

    臨床麻酔   44 ( 7 )   947 - 954   2020.7

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to ozaliplatin-induced chronic neuropathic pain. Reviewed

    Toyoaki Maruta, Takayuki Nemoto, Koutaro Hidaka, Tomohiro Koshida, Tetsuro Shirasaka, Toshihiko Yanagita, Ryu Takeya Isao Tsuneyoshi

    PLoS ONE   14 ( 11 )   e0225586   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PLoS ONE  

    © 2019 Maruta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Oxaliplatin is the first-line chemotherapy for metastatic colorectal cancer. Unlike other platinum anticancer agents, oxaliplatin does not result in significant renal impairment and ototoxicity. Oxaliplatin, however, has been associated with acute and chronic peripheral neuropathies. Despite the awareness of these side-effects, the underlying mechanisms are yet to be clearly established. Therefore, in this study, we aimed to understand the factors involved in the generation of chronic neuropathy elicited by oxaliplatin treatment. We established a rat model of oxaliplatin-induced neuropathic pain (4 mg kg-1 intraperitoneally). The paw withdrawal thresholds were assessed at different time-points after the treatment, and a significant decrease was observed 3 and 4 weeks after oxaliplatin treatment as compared to the vehicle treatment (4.4 ± 1.0 vs. 16.0 ± 4.1 g; P < 0.05 and 4.4 ± 0.7 vs. 14.8 ± 3.1 g; P < 0.05, respectively). We further evaluated the role of different mitogen-activated protein kinases (MAPKs) pathways in the pathophysiology of neuropathic pain. Although the levels of total extracellular signal-regulated kinase (ERK) 1/2 in the dorsal root ganglia (DRG) were not different between oxaliplatin and vehicle treatment groups, phosphorylated ERK (pERK) 1/2 was up-regulated up to 4.5-fold in the oxaliplatin group. Administration of ERK inhibitor PD98059 (6 μg day-1 intrathecally) inhibited oxaliplatin-induced ERK phosphorylation and neuropathic pain. Therefore, upregulation of p-ERK by oxaliplatin in rat DRG and inhibition of mechanical allodynia by an ERK inhibitor in the present study may provide a better understanding of intracellular molecular alterations associated with oxaliplatin-induced neuropathic pain and help in the development of potential therapeutics.

    DOI: 10.1371/journal.pone.0225586



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Books 【 display / non-display

MISC 【 display / non-display

  • 気管挿管における気管チューブの理想的なカフ圧‐時間曲線の検討

    河野太郎, 指宿昌一郎, 丸田豊明, 矢野武志, 児玉芳史, 石山健次郎, 新福玄二, 森信一郎, 恒吉勇男, 恒吉勇男

    日本集中治療医学会学術集会(Web)   45th ( Suppl. )   ROMBUNNO.P1‐1 (WEB ONLY) - 1]   2018.2

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:(一社)日本集中治療医学会  



  • 先天性QT延長症候群でフェニレフリンが多源性心室頻拍とS‐ICDの誘発試験に関与した1症例

    河野太郎, 丸田豊明, 児玉芳史, 長嶺佳弘, 内村修二, 溜渕昌美, 金丸容子, 恒吉勇男

    Cardiovascular Anesthesia   21 ( Suppl )   369 - 369   2017.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:(一社)日本心臓血管麻酔学会  



  • Postoperative analgesia after skin laser irradiation surgery in pediatrics: a single-center retrospective observational study

    丸田豊明, 興梠聡志, 黒木俊介, 長嶺佳弘, 児玉芳史, 門田瑶子, 恒吉勇男

    日本小児麻酔学会誌   23 ( 1 )   169‐173 - 173   2017.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:日本小児麻酔学会  




  • PICCにより右房内血栓を形成し開心術を行った1症例

    児玉芳史, 君安貴寛, 丸田豊明, 太田尾剛, 白阪哲朗, 恒吉勇男

    日本循環制御医学会総会(Web)   38th   ROMBUNNO.O‐11 (WEB ONLY) - 70   2017.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:日本循環制御医学会  



  • 当施設における末梢挿入型中心静脈カテーテル留置症例の安全性の検討‐がん患者と非がん患者の後ろ向き比較‐

    丸田望, 丸田豊明, 高橋稔之, 和田徹也

    Palliative Care Research (Web)   12 ( 1 )   169‐174(J‐STAGE) - 174   2017.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:(NPO)日本緩和医療学会  

    【目的】末梢挿入型中心静脈カテーテル(peripherally inserted central venous catheter:PICC)留置症例をがん患者と非がん患者で比較し,安全性の検討を行った.【方法】PICCを留置した患者で留置目的・留置期間・合併症の有無などを後ろ向きに比較した.【結果】がん患者は88例,非がん患者は69例であった(以下,がん患者vs.非がん患者).留置目的は高カロリー輸液投与が45 vs. 51例,末梢静脈路確保困難が40 vs. 12例であった(p=0.0022).留置期間は15(6-39) vs. 21(12-40)日であった(p<0.0001).PICC留置に伴う合併症を認めたのは8 vs. 9例で有意差はなかったが,カテーテル関連血流感染は非がん患者で多かった(0.9 vs. 2.0件/1000カテーテル日,p=0.041).【考察】PICCによる合併症発生率はどちらも低く,PICCの安全性が示された.(著者抄録)

    DOI: 10.2512/jspm.12.169



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Presentations 【 display / non-display

  • オプトジェネティクスを用いた末梢神経疼痛モデル動物の開発(優秀演題(基礎編))


    第42回日本疼痛学会  2020.12.4 

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    Event date: 2020.12.4 - 2020.12.5

    Language:Japanese   Presentation type:Oral presentation (general)  

  • ロボット支援腹腔鏡下前立腺摘出術で生じた全身性皮下気腫の一例.

    永田悠紀子,川﨑祐子,押川 隆,加藤彩鳥,丸田豊明,恒吉勇男

    日本臨床麻酔学会第40回大会  2020.11 

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    Event date: 2020.11.6 - 2020.12.14


  • キサリプラチン誘発神経障害性疼痛に関連する細胞内シグナル分子の解析.

    根本隆行,丸田豊明,武谷 立,恒吉勇男,岩本隆宏

    第49回日本心脈管作動物質学会  2020.2.7 

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    Event date: 2020.2.7 - 2020.2.8

    Language:Japanese   Presentation type:Poster presentation  

  • オキサリプラチン誘発性神経障害性疼痛におけるERKシグナルの関与.


    第72回日本薬理学会西南部会  (沖縄)  第72回日本薬理学会西南部会

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    Event date: 2019.11.16

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  • 食道癌が左肺に穿破した患者で高頻度ジェット換気を併用した分離肺換気を行った麻酔経験.

    菓子野里奈,澤田 修,佐藤文明,緑川沙樹,丸田豊明,恒吉勇男

    九州麻酔学会第57回大会  (福岡)  九州麻酔学会

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    Event date: 2019.9.14

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Grant-in-Aid for Scientific Research 【 display / non-display

  • オプトジェネティクスを用いた神経障害性疼痛モデルマウスの作製と疼痛機序の解明

    Grant number:21K08925  2021.04 - 2024.03

    独立行政法人日本学術振興会  基盤研究(C)

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    Authorship:Principal investigator 

  • オプトジェネティクスを用いた光による痛み制御 ~実験動物の開発と疼痛機序の解明~

    2018 - 2021.03

    科学研究費補助金  基盤研究(C)

Other research activities 【 display / non-display

  • BAOJ Medical and Nursing


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  • SDRP Journal Of Anesthesia & Surgery


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