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Affiliation |
Faculty of Agriculture Department of Veterinary Science Animal clinical breeding study course |
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Title |
Associate Professor |
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External Link |
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KITAHARA Go
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Degree 【 display / non-display 】
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博士（獣医学） ( 2012.9 山口大学 )
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学士（獣医学） ( 2002.3 鹿児島大学 )
Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
Papers 【 display / non-display 】
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Profile of uterine flush lipid mediators in cows with subclinical endometritis: pilot study Reviewed
MAEHARA Toko, OSAWA Takeshi, KITAHARA Go, SATOH Hiroshi, MURATA Takahisa
Journal of Veterinary Medical Science advpub ( 0 ) 2024.3
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
DOI： 10.1292/jvms.23-0450
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Use of platelet lysate for in-vitro embryo production and treatment of repeat breeding in cows Reviewed International coauthorship
Hassaneen A.S.A., Rawy M.S., Yamanokuchi E., Elgendy O., Kawano T., Wakitani S., Kitahara G., Osawa T.
Theriogenology 210 199 - 206 2023.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Theriogenology
Platelet-rich plasma (PRP) is a biological hemocomponent derived from blood after the complete removal of red blood cells and the partial or complete removal of white blood cells to concentrate platelets in an appropriate volume of plasma. Platelets have important growth factors, cytokines, and active metabolites that improve the endometrial environment and positively affect implantation. This study evaluated the effect of the addition of activated PRP (platelets lysate; PL) on in vitro bovine oocyte maturation and embryonic development and the effect of intrauterine (IU) infusion of autologous PL in repeat breeder (RB) cows. Experiment 1 examined the effects of allogeneic PL, fetal calf serum (FCS), mixed PL + FCS, or platelet-poor plasma (PPP) supplementations to in vitro maturation and development media on in vitro oocyte maturation and embryo development in good- and poor-quality oocytes of Japanese Black cows. Experiment 2 examined the IU infusion of autologous PL, 24 h post-insemination, in 21 RB Holstein-Friesian dairy cows. The cleavage rate of good-quality oocytes was higher in the PL group (85.93 ± 2.50%) than in the PPP group (67.16 ± 3.41%) (P < 0.05), while the cleavage rate of the poor-quality oocytes was higher in the PL alone (76.13 ± 4.04%) and mixed PL + FCS treated (73.59 ± 4.22%) groups than in the PPP group (54.64 ± 2.93%) (P < 0.05). The blastocyst rate of the good-quality oocytes was higher in the PL group (40.97 ± 3.03%) than in the FCS (27.97 ± 3.31%) and PPP (25.33 ± 2.15%) groups (P < 0.05). The blastocyst rate of poor-quality oocytes and the hatching rates of both good and poor-quality oocytes showed no significant differences among all groups. The conception rate in the autologous PL-treated group was 41.67% (5/12), while it was 11.11% (1/9) in the control group. The platelets' count in the pregnant PL-treated cows (n = 5; mean ± SEM, 1.07 ± 0.10 × 109/mL) was higher than in the non-pregnant ones (n = 7; 0.67 ± 0.10 × 109/mL) (P < 0.05). In conclusion, allogeneic PL was effective in stimulating the in vitro oocyte maturation and embryonic development in both good and poor-quality bovine oocytes, and post-insemination IU infusion of autologous PL derived from high platelets’ count-PRP would be recommended for the treatment of RB cows.
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5-Aminolevulinic acid/sodium ferrous citrate improves the quality of heat-stressed bovine oocytes by reducing oxidative stress Reviewed
ELGENDY Omnia, KITAHARA Go, YAMADA Kentaro, TANIGUCHI Shin, OSAWA Takeshi
Journal of Reproduction and Development 69 ( 5 ) 261 - 269 2023.8
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：The Society for Reproduction and Development
DOI： 10.1262/jrd.2023-038
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Usefulness of computed tomography for cryptorchidism in bulls Reviewed
GODA Yoshimichi, MIZUTANI Shinya, MIZUTANI Yuko, KITAHARA Go, SISWANDI Riki, WAKABAYASHI Kenta, TORISU Shidow, KANEKO Yasuyuki, HIDAKA Yuichi, OSAWA Takeshi, ASANUMA Taketoshi, SATO Reiichiro, SATOH Hiroyuki
Journal of Veterinary Medical Science 84 ( 10 ) 1430 - 1436 2022.10
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
<p>Cryptorchidism is defined as the failure of the testis to descend into the scrotal position. Bulls with cryptorchidism have problems in both meat quality and husbandry management; thus, it is greatly important to accurately identify the retained testis and remove it during the early stage. Abdominal computed tomography (CT) was performed under general anesthesia in 34 bulls aged 3–9 months with cryptorchidism. All bulls underwent laparoscopic or incision approach for cryptorchidectomy, and 40 testes were dissected. The detection rates of retained testes were 64.5% in the abdominal cavity and 100% in the subcutaneous inguinal region, and the total detection rate was 72.5%. Furthermore, all cases in this study were suspected to have intra-abdominal cryptorchidism in primary care, but CT revealed that 22.5% of cases had cryptorchidism in the subcutaneous inguinal region. The CT value (mean ± standard deviation) of the retained testes was 20.96 ± 7.54 Hounsfield Unit, and the CT value and size of the retained testes showed a positive weak correlation with bovine age. Therefore, there is the demerit that general anesthesia and a huge device are necessary; nevertheless, CT is suggested to be useful in identifying the location of retained testes and selecting an appropriate surgical approach in bulls with cryptorchidism. Moreover, CT findings suggested that the maturation of the retained testes might depend not on the descending process but on age.</p>
DOI： 10.1292/jvms.22-0124
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Misaka M., Uematsu M., Hashimoto K., Kitahara G., Osawa T., Sasaki Y.
Preventive Veterinary Medicine 207 105716 2022.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Preventive Veterinary Medicine
Calf mortality severely affects productivity in the beef industry. The present study was conducted to assess the calf mortality risk (CMR) in Japanese Black calves and investigate potential associations between calf/cow information and the CMR. Records for calves born between April 2006 and March 2010 were extracted from an existing database, which included production data on commercial cow-calf operations in Miyazaki, Japan. The study group comprised 40,462 calves born to 15,600 cows on 908 farms. Because calves on the studied farms were weaned at approximately 4 months of age, the calf records were collected from birth to 120 days. The CMR was calculated as the number of dead calves divided by the number of surviving calves. Mixed-effect multivariable logistic regression modeling was used to determine potential associations between the CMR and the factors hypothesized to influence that risk. CMR analyses were performed separately for the following production stages: days 0–30, days 31–60, days 61–90 and days 91–120 after birth. Of the 40,462 calves, 1465 died during days 0–120 after birth, and the CMR was 3.6 %. Of the 1465 dead calves, 35.9 % died within 10 days after birth. During the 0–30-day period, the CMR was associated with dam parity, calving status, gestation length, sex, birth season and twin births (P < 0.05), but not with the number of inseminations to conception. Low parity, dystocia, gestation lengths < 280 days and > 301 days, male calves, calves born in autumn and winter and twin births yielded higher CMRs. Low dam parity also yielded higher CMRs during the 31–60-day, 61–90-day and 91–120-day periods (P < 0.05), but no other factors were associated with the CMR during these periods. Thus, various cow and calf factors were shown to be associated with CMRs in Japanese Black calves, and calves with these factors should be considered high-risk calves.
Books 【 display / non-display 】
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獣医繁殖学第5版
獣医繁殖学教育協議会（ Role： Contributor , 泌乳の生理、生殖器の先天異常、泌乳の異常）
文永堂出版株式会社 2023.9
Language：Japanese Book type：Scholarly book
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牛のマタニティハンドブック
大澤健司・三宅陽一編（ Role： Contributor , P40-45, 54-60）
文永堂出版株式会社 2022.11
Language：Japanese Book type：Scholarly book
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大・中・小動物実験プロトコール
宮崎大学動物実験プロトコール編集委員会（ Role： Joint author）
宮日文化情報センター 2016.3
Language：Japanese Book type：Scholarly book
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畜産ハンドブック 2.6 性の役割と性分化
北原 豪（ Role： Sole author）
（株）講談社サイエンティフィク 2014.7
Language：Japanese Book type：Dictionary, encyclopedia
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子牛の医学 第7章泌尿・生殖器疾患 第4節 生殖器の異常
北原 豪（ Role： Supervisor (editorial)）
緑書房 2014.3
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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海外テクニカルニュース：繁殖状況と性別を含めた牛の生殖道におけるマイクロバイオームの解明 Invited
北原 豪
臨床獣医 42 ( 3 ) 64 - 65 2024.3
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：緑書房
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海外テクニカルニュース：乳用経産および未経産牛における妊娠による子宮の異なる部位での超音波画像の見え方 Invited
北原 豪
臨床獣医 42 ( 2 ) 64 - 65 2024.2
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：緑書房
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海外テクニカルニュース：乳用未経産牛の妊娠後期における難産を予測するための体内外の計測による臨床応用の可能性 Invited
北原 豪
臨床獣医 42 ( 1 ) 60 - 61 2024.1
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：緑書房
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海外テクニカルニュース：スコットランドの乳牛群における超音波検査で診断された子宮内膜炎のリスク因子とその繁殖性に及ぼす影響 Invited
北原 豪
臨床獣医 41 ( 12 ) 68 - 69 2023.12
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：緑書房
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海外テクニカルニュース：総説：乳牛の乳房炎が繁殖性に影響を与えるメカニズム Invited
北原 豪
臨床獣医 41 ( 11 ) 72 - 73 2023.11
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：緑書房
Presentations 【 display / non-display 】
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難産牛の分娩後 2 週までにおける血清アミロイドA（SAA）濃度と悪露中の炎症関連サイトカインの動態
谷田部 陽美、小東 史織、金丸 和之、北原 豪、上松 瑞穂、大澤 健司
第41回日本獣医師会獣医学術学会年次大会 (Web) 日本獣医師会
Event date： 2023.12.1 - 2023.12.3
Language：Japanese Presentation type：Oral presentation (general)
Venue：Web
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黒毛和種経産牛の正常分娩に伴う子宮頸管熟化における炎症性サイトカインmRNAの動態
金丸 和之、北原 豪、上松瑞穂、邉見 広一郎、小林 郁雄、大澤 健司
第116回日本繁殖生物学会大会 (Web) 日本繁殖生物学会
Event date： 2023.9.24 - 2023.9.27
Language：Japanese Presentation type：Oral presentation (general)
Venue：Web
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難産牛の分娩後1週から2週における悪露中の炎症性サイトカインの動態
谷田部 陽美、小東 史織、金丸 和之、北原 豪、上松 瑞穂、大澤 健司
第166回日本獣医学会学術集会 (Web) 日本獣医学会
Event date： 2023.9.5 - 2023.9.8
Language：Japanese Presentation type：Oral presentation (general)
Venue：Web
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黒毛和種妊娠牛における妊娠関連糖タンパク質およびエストロンサルフェートによる難産予測の可能性
前田 崇史、北原 豪、大澤 健司
第166回日本獣医学会学術集会 (Web) 日本獣医学会
Event date： 2023.9.5 - 2023.9.8
Language：Japanese Presentation type：Oral presentation (general)
Venue：Web
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黒毛和種牛の子宮頸管粘液中炎症性サイトカインによる長期在胎および難産の予測
金丸 和之、北原 豪、上松瑞穂、邉見 広一郎、小林 郁雄、大澤 健司
第166回日本獣医学会学術集会 (Web) 日本獣医学会
Event date： 2023.9.5 - 2023.9.8
Language：Japanese Presentation type：Oral presentation (general)
Venue：Web
Awards 【 display / non-display 】
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第166回日本獣医学会学術集会優秀発表賞
2023.9 日本獣医学会
小東 史織、北原 豪、上松 瑞穂、大澤 健司
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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English Presentation Award
2019.3
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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平成30年度日本獣医師会獣医学術学会年次大会学会長賞
2019.2 日本産業動物獣医学会
鳥巣至道、保坂悠歩、金子泰之、北原豪、日髙勇一、桐野有美、水谷真也、山本集士
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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平成30年度獣医学術九州地区学会産業動物獣医学会地区学会長賞
2018.10 日本産業動物獣医学会九州地区学会
保坂悠歩、鳥巣至道、金子泰之、北原豪、佐藤裕之、水谷真也、山本集士、Benedict Huai Ern ONG、水谷祐子、桐野有美、日髙勇一、浅沼武敏、永延清和
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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平成29年家畜診療賞
2018.2 全国農業共済協会
佐藤知広，北原 豪，大澤健司
Award type：Honored in official journal of a scientific society, scientific journal Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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牛の子宮頚管熟化機構の解明と分娩後早期の一過性炎症惹起による子宮疾患制御
Grant number：21H02362 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
大澤 健司
Authorship：Coinvestigator(s)
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ウシ潜在性子宮内膜炎の病態解明と治療・予防ストラテジーの確立
Grant number：16H05038 2016.04 - 2020.03
科学研究費補助金 基盤研究(B)
Authorship：Coinvestigator(s)
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GhrelinとNeuromedin U/Sの自律神経様作用の解明と応用への研究
Grant number：16H05043 2016.04 - 2020.03
科学研究費補助金 基盤研究(B)
Authorship：Coinvestigator(s)
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バイオマーカーによる家畜の卵巣機能の質および量的評価法の確立
Grant number：16K18805 2016.04 - 2019.03
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
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抗ミューラー管ホルモンを用いた新しい繁殖管理技術の開発
Grant number：25850209 2013.04 - 2016.03
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
これまで国内外で調べられていない雌ウシの春機発動時期と周産期におけるAMHの動態を明らかにし、初産分娩月齢や分娩後の空胎日数などの繁殖効率の指標となる繁殖成績との関係を解析して、AMHをバイオマーカーとした生時より備わっている繁殖能力や周産期における非生産時の繁殖機能を評価する新しい繁殖管理技術の開発に挑む。
Available Technology 【 display / non-display 】
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臨床バイオマーカーを活用した産業動物の繁殖機能評価の開発
効率的な体外胚作出のための培養環境の開発
妊娠期の母牛の栄養状態と胎子・新生子の将来に及ぼす影響に関する研究Related fields where technical consultation is available：産業動物の繁殖機能の評価
胚発生に関わる研究Message：掲げた研究テーマにご興味のある方は、是非、ご連絡ください。