|
Affiliation |
Faculty of Medicine School of Medicine Department of Infectious Diseases, Parasitology |
|
Title |
Associate Professor |
|
External Link |
|
|
Related SDGs |
|
NAGAYASU Eiji
|
|
|
Degree 【 display / non-display 】
-
博士（医学） ( 2002.3 東海大学 )
-
学士（医学） ( 1998.3 宮崎医科大学 )
Papers 【 display / non-display 】
-
False-positive hepatitis C virus (HCV) antibody result associated with tapeworm infection: A potential emerging public health concern in HCV diagnosis-A case report. Reviewed International journal
Yusuke Ainoda, Eiji Nagayasu, Haruhiko Maruyama, Yuji Hirai
Diagnostic microbiology and infectious disease 116 ( 3 ) 117516 - 117516 2026.11
Language：English Publishing type：Research paper (scientific journal)
Various conditions, including schistosomiasis, have been reported as potential causes of false-positive hepatitis C virus (HCV) antibody test results; however, there have been few reports of false-positive results associated with cestodiasis or reports of HCV antibody test results turning negative following deworming. In this report, we describe a woman in her 30 s with tapeworm infection who showed a false-positive HCV antibody test result that turned negative after deworming. False-positive HCV antibody results associated with cestodiasis may represent a particular diagnostic challenge in developing countries, where confirmatory HCV genetic testing is less readily available.
-
Toxocariasis presenting with peripheral eosinophilia and eosinophilic pleural effusion: A case report. Reviewed International journal
Mizuki Nanri, Hiroki Tashiro, Yuta Kishikawa, Yuki Kuwahara, Teturo Haraguchi, Yuki Kurihara, Shinsuke Ogusu, Chiho Nakashima, Eiji Nagayasu, Mio Kokubo-Tanaka, Haruhiko Maruyama, Koichiro Takahashi
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 32 ( 8 ) 103019 - 103019 2026.8
Language：English Publishing type：Research paper (scientific journal)
Human toxocariasis is a parasitic infection caused by Toxocara species and is important in the differential diagnosis of patients presenting with unexplained eosinophilia. A case of toxocariasis with an eosinophilic pleural effusion is presented. A 67-year-old Japanese man presented with progressive dyspnea. Laboratory investigations showed marked peripheral eosinophilia and a markedly elevated serum immunoglobulin E level. Chest imaging demonstrated bilateral ground-glass opacities and a left-sided pleural effusion. Analysis of the pleural fluid showed eosinophil predominance without evidence of malignancy or bacterial infection. Extensive diagnostic evaluations, including autoimmune serology, bone marrow examination, and genetic analyses for myeloid neoplasms with eosinophilia, yielded negative results. Serological test using an enzyme-linked immunosorbent assay demonstrated elevated anti-Toxocara antibody level, which were subsequently confirmed by Western blot analysis, leading to a diagnosis of human toxocariasis presenting with visceral larva migrans. The patient had no clear history of animal contact or ingestion of raw meat or liver. Treatment with oral albendazole for four weeks resulted in marked clinical improvement, with resolution of the pleural effusion and pulmonary infiltrates, normalization of peripheral eosinophil counts, and a significant decrease in anti-Toxocara antibody level. This case emphasizes the importance of considering toxocariasis in the differential diagnosis of an eosinophilic pleural effusion and pulmonary infiltrates, even in the absence of identifiable exposure risks. Early serological testing can facilitate prompt diagnosis and appropriate anthelmintic therapy, potentially preventing unnecessary invasive procedures and delayed treatment.
-
Unusual aspect of cuticular morphology in human pulmonary dirofilariasis. Reviewed
Nagayasu E, Kasai T, Ishikura H, Hasegawa H, Kokubo-Tanaka M, Maruyama H
Parasitology international 116 103337 2026.7
Language：English Publishing type：Research paper (scientific journal)
-
Ikenaga Eri, Nagayasu Eiji, Hasegawa Hideo, Murota Hiroyuki, Kuwatsuka Yutaka
Parasite 33 23 2026.4
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：EDP Sciences
Zoonotic onchocerciasis is a rare human infection caused by Onchocerca species that normally parasitize non-human mammals. In Japan, all previously reported human cases have been attributed to Onchocerca japonica and have presented as localized, non-migratory subcutaneous nodules. Here, we report the first human infection caused by Onchocerca takaokai Uni et al., 2015. A 24-year-old male presented with linear migratory erythema on the forearm, clinically consistent with creeping eruption. Histopathological examination revealed an adult female filarial nematode with polymyarian-coelomyarian musculature, without internal cuticular ridges in the lateral cords, and lacking transverse ridges on the cuticle. Molecular analyses of the mitochondrial 12S rRNA and cytochrome c oxidase subunit I (cox1) genes confirmed that the parasite was O. takaokai, a parasite of wild boars in Japan. This case demonstrates a clinical presentation distinct from that of O. japonica and suggests that O. takaokai should be considered in the differential diagnosis of creeping eruption in endemic areas.
-
Declining Seroprevalence of Strongyloidiasis in Okinawa, Japan: A Cross-Sectional Study Reviewed
Akihiro Kosuge, Naoyuki Fukuda, Asano Funakoshi, Naoko Yoshida, Eiji Nagayasu, Takashi Miida, Teruyuki Hachiman, Haruhiko Maruyama, Haruo Obara, Toshihiro Mita
American Journal of Tropical Medicine & Hygiene 2026.1
Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
-
さっと読めてパッとわかる！ 感染症診断メモ (分担:糞線虫症を疑った時、どのような検査を実施し、どのように提出すればよいでしょうか？
長安 英治（ Role： Sole author）
医学書院 2025.4
Total pages：4
-
今日の診断指針 第9版
長安 英治（ Role： Contributor , 糞線虫症）
医学書院 2025.2
Language：Japanese Book type：Textbook, survey, introduction
-
今日の治療指針 2025
長安 英治（ Role： Contributor , 糞線虫症）
医学書院 2024.1
Language：Japanese Book type：Textbook, survey, introduction
MISC 【 display / non-display 】
-
【サッと読めてパッとわかる! 感染症診断メモ。】(3章)寄生虫感染症 糞線虫症を疑ったとき,どのような検査を実施し,どのように提出すればよいでしょうか? Invited
長安 英治, 小菅 顕大, 椎木 創一
臨床検査 69 ( 4 ) 364 - 367 2025.4
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
-
複数の抗原を用いた糞線虫抗体価測定法の開発
日向 綾子, Nzou Samson Muuo, 森保 妙子, 田中 美緒, 濱野 真二郎, 長安 英治, 丸山 治彦, 金子 聰
日本寄生虫学会・日本臨床寄生虫学会合同大会プログラム・抄録集 90回・32回 83 - 83 2021.4
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本寄生虫学会・日本臨床寄生虫学会
-
ヒトとイヌに由来するStrongyloides stercoralisの分子系統解析
29 ( 1 ) 21 - 23 2018.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
-
【多様化する感染症研究】 熱帯寄生虫症に対する集団投薬の最適化の必要性(解説/特集) Invited
長安 英治
細胞 49 ( 14 ) 704 - 707 2017.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
-
【寄生虫症(II)】 糞線虫症研究の新展開(解説/特集) Invited
長安 英治, 菊池 泰生, 丸山 治彦
医学と薬学 74 ( 11 ) 1407 - 1414 2017.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
-
Elucidating the Phylogeny of Strongyloides: inclusion of Latin American species International coauthorship
Eiji Nagayasu, Laura Florita Trujillo Mundo, Mirle Cachique Pinche, Jorge Manuel Cardenas Callirgos, Jose Iannacone Oliver, and Haruhiko Maruyama
第15回蠕虫研究会 2024.8.20
Event date： 2024.8.19 - 2024.8.20
Language：Japanese Presentation type：Oral presentation (general)
-
ネズミ糞線虫およびベネズエラ糞線虫宿主体内移行経路の再検討
田中 美緒、加藤 さらさ、Yulia Dwi Setia、Safira Rosalina、田中 龍聖、長安 英治、 吉田 彩子、丸山 治彦
第15回蠕虫研究会 2024.8.19
Event date： 2024.8.19 - 2024.8.20
Language：Japanese Presentation type：Oral presentation (general)
-
A Case of Sparganosis Mansoni
Hiromi Narita, Yujiro Asada, Eiji Nagayasu, Haruhiko Maruyama
The Japanese Dermatological Association 164th Miyazaki regional meeting
Event date： 2024.4.6 - 2024.4.7
Language：Japanese Presentation type：Oral presentation (general)
-
On the evolutionary scenario of Strongyloides spp. of primates: discovery of a novel member in the stercoralis-procyonis clade in Gabon International coauthorship
Eiji Nagayasu, Patrice Makouloutou Nzassi, Larson Boundenga, Haruhiko Maruyama
第93回日本寄生虫学会大会 2024.3
Event date： 2024.3.9 - 2024.3.10
Language：Japanese Presentation type：Oral presentation (general)
-
Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice
Setia Yulia Dwi, 田中 美緒, 田中 龍聖, 長安 英治, Parinian Ahmadi, 入江 隆夫, 吉田 彩子, 丸山 治彦
第93回日本寄生虫学会大会 2024.3
Event date： 2024.3.9 - 2024.3.10
Language：English Presentation type：Poster presentation
Grant-in-Aid for Scientific Research 【 display / non-display 】
-
ネコ型亜目動物寄生性糞線虫の多様性・系統関係・異種宿主間感染に関する実態解明調査
Grant number：25K10336 2025.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator
-
Elucidation of pathophysiology of proliferative sparganosis-like Spirometra infection by whole genome re-sequencing and expression profiling of infecting worms
Grant number：24K10192 2024.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Coinvestigator(s)
-
寄生虫の分子同定と系統解析のための統一標準法の確立
Grant number：21H02725 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
丸山 治彦、長安 英治
Authorship：Coinvestigator(s)
-
ヒト糞線虫の起源：アジア、アフリカ、南米の霊長類を中心としたサンプリングから
Grant number：20K07464 2020.04 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator
-
Investigation of seroprevalence and transmission routes for Paragonimus westermani infection in sika deer
Grant number：17K08082 2017.04 - 2020.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Yoshida Ayako
Authorship：Coinvestigator(s)
Seroprevalence of Paragonimus infection in sika deer was evaluated to assess the risk of paragonimiasis through venison consumption. Total 1,546 blood samples collected from sika deer from February 2013 to March 2020 in western Japan were tested by pre-adsorbed ELISA, and 1.4 % of them were positive for anti-Paragonimus antibodies. Our results suggested that venison can be a risk of the infection in the endemic areas of paragonimiasis, although the infection risk of venison would be lower than that of wild boar meat considering the positive rate in wild boars in these areas (9.1-43.0%). In addition, the leg of Japanese freshwater crab, Geothelphusa dehaani, was found in the rumen of sika deer, suggesting sika deer got Paragonimus infection by the ingestion of Japanese freshwater crab, the first intermediate host.
Other research activities 【 display / non-display 】
-
ミャンマーにおける糞線虫症フィールド調査
2015.01
ミャンマーにおける糞線虫症のフィールド調査
-
ウガンダにおける寄生虫症フィールドワーク
2014.10 - 2014.11
ウガンダにおけるフィラリア症の流行状況の調査
-
ウガンダにおける寄生虫症フィールドワーク
2014.05
ウガンダにおけるマラリア感染者及び非感染者における腸内細菌叢の解析
-
ミャンマーにおける寄生虫症共同研究
2014.01 - 2014.02
University of Medicine (1), Yangonにおける寄生虫症に関するセミナー及び共同研究の実施
-
ウガンダにおける寄生虫症フィールドワーク
2013.10 - 2013.11
Gulu大学との国際共同研究