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Faculty of Medicine School of Medicine Department of Infectious Diseases, Parasitology |
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Associate Professor |
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Related SDGs |
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NAGAYASU Eiji
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Degree 【 display / non-display 】
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博士（医学） ( 2002.3 東海大学 )
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学士（医学） ( 1998.3 宮崎医科大学 )
Papers 【 display / non-display 】
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Declining Seroprevalence of Strongyloidiasis in Okinawa, Japan: A Cross-Sectional Study Reviewed
Akihiro Kosuge, Naoyuki Fukuda, Asano Funakoshi, Naoko Yoshida, Eiji Nagayasu, Takashi Miida, Teruyuki Hachiman, Haruhiko Maruyama, Haruo Obara, Toshihiro Mita
American Journal of Tropical Medicine & Hygiene 2026.1
Language：English Publishing type：Research paper (scientific journal)
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Continuous occurrence of human thelaziasis in Fukushima Prefecture: An incidental case detected during cataract surgery Reviewed
Eiji Nagayasu, Makiko Ono, Hideo Hasegawa, Haruhiko Maruyama
36 ( 1 ) 28 - 32 2025.12
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Case report
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Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice Reviewed
Setia Y.D., Kokubo-Tanaka M., Tanaka R., Yoshida A., Nagayasu E., Ahmadi P., Yoshida A., Maruyama H.
Frontiers in Parasitology 4 2025.6
Publishing type：Research paper (scientific journal) Publisher：Frontiers in Parasitology
Introduction: Eimeria pragensis, an intestinal protozoa infecting mice, induces colitis and reduces goblet cell numbers in the large intestine. In the present study, we investigated the pathogenesis and the mechanisms underlying goblet cell down-regulation in the early phase of infection. Methods: Male C57BL/6 mice were orally infected with 300 oocysts. Fecal oocyst shedding and body weight were monitored daily. Colon tissues were collected at 3, 8, and 13 days post-infection (dpi) to assess pathological changes. Parasite burden was assessed by histological analysis (H&E staining) and qPCR targeting 5S rRNA. Goblet cells were visualized using PAS-Alcian Blue staining and Muc2 immunohistochemistry. To elucidate mechanisms of goblet cell dysfunction, we performed RNA sequencing of large intestine tissue to examine host as well as parasite transcriptomes. Results: Fecal oocyst excretion peaked at 8–9 dpi. Body weight decreased from 6 to 11 dpi, with recovery after 12 dpi. Maximal parasite accumulation in the proximal colon was observed at 8 dpi in histological examination as well as qPCR. Colon length was significantly shortened at 3 dpi. Goblet cell area significantly reduced at 8 dpi (p < 0.05). RNA sequencing of infected large intestines revealed that E. pragensis produced enzymes that were known to degrade mucin and tight junctions, and proteins that could activate the Notch–Hes1 signaling pathway. As for host responses, genes associated with Th1-type inflammation, epithelial barrier disruption, and immune regulation were up-regulated as early as 3 dpi. Discussion: Our findings suggested that E. pragensis infection induces a mucosal barrier dysfunction in the early phase of the infection, which possibly causes the tissue invasion of bacteria in the large intestine. Th1-type inflammatory response, thus induced, reduces goblet cell numbers and mucin production. This model provides valuable insight into the mechanisms of mucosal barrier disruption during protozoan infection.
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臨床報告 福島県内で感染したと推定される東洋眼虫症の1例 Reviewed
冨田 隆太郎, 長谷川 英男, 長安 英治, 小島 彰
臨床眼科 78 ( 12 ) 1393 - 1398 2024.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：株式会社医学書院
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A surgical case of inflammatory pseudotumor by hepatic anisakiasis. Reviewed
Kotaro Ito, Takao Ide, Tomokazu Tanaka, Eiji Nagayasu, Hideo Hasegawa, Hirokazu Noshiro
Clinical journal of gastroenterology 2023.12
Books 【 display / non-display 】
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さっと読めてパッとわかる！ 感染症診断メモ (分担:糞線虫症を疑った時、どのような検査を実施し、どのように提出すればよいでしょうか？
長安 英治（ Role： Sole author）
医学書院 2025.4
Total pages：4
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今日の診断指針 第9版
長安 英治（ Role： Contributor , 糞線虫症）
医学書院 2025.2
Language：Japanese Book type：Textbook, survey, introduction
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今日の治療指針 2025
長安 英治（ Role： Contributor , 糞線虫症）
医学書院 2024.1
Language：Japanese Book type：Textbook, survey, introduction
MISC 【 display / non-display 】
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【サッと読めてパッとわかる! 感染症診断メモ。】(3章)寄生虫感染症 糞線虫症を疑ったとき,どのような検査を実施し,どのように提出すればよいでしょうか? Invited
長安 英治, 小菅 顕大, 椎木 創一
臨床検査 69 ( 4 ) 364 - 367 2025.4
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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複数の抗原を用いた糞線虫抗体価測定法の開発
日向 綾子, Nzou Samson Muuo, 森保 妙子, 田中 美緒, 濱野 真二郎, 長安 英治, 丸山 治彦, 金子 聰
日本寄生虫学会・日本臨床寄生虫学会合同大会プログラム・抄録集 90回・32回 83 - 83 2021.4
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本寄生虫学会・日本臨床寄生虫学会
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ヒトとイヌに由来するStrongyloides stercoralisの分子系統解析
29 ( 1 ) 21 - 23 2018.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【多様化する感染症研究】 熱帯寄生虫症に対する集団投薬の最適化の必要性(解説/特集) Invited
長安 英治
細胞 49 ( 14 ) 704 - 707 2017.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【寄生虫症(II)】 糞線虫症研究の新展開(解説/特集) Invited
長安 英治, 菊池 泰生, 丸山 治彦
医学と薬学 74 ( 11 ) 1407 - 1414 2017.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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Elucidating the Phylogeny of Strongyloides: inclusion of Latin American species International coauthorship
Eiji Nagayasu, Laura Florita Trujillo Mundo, Mirle Cachique Pinche, Jorge Manuel Cardenas Callirgos, Jose Iannacone Oliver, and Haruhiko Maruyama
第15回蠕虫研究会 2024.8.20
Event date： 2024.8.19 - 2024.8.20
Language：Japanese Presentation type：Oral presentation (general)
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ネズミ糞線虫およびベネズエラ糞線虫宿主体内移行経路の再検討
田中 美緒、加藤 さらさ、Yulia Dwi Setia、Safira Rosalina、田中 龍聖、長安 英治、 吉田 彩子、丸山 治彦
第15回蠕虫研究会 2024.8.19
Event date： 2024.8.19 - 2024.8.20
Language：Japanese Presentation type：Oral presentation (general)
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A Case of Sparganosis Mansoni
Hiromi Narita, Yujiro Asada, Eiji Nagayasu, Haruhiko Maruyama
The Japanese Dermatological Association 164th Miyazaki regional meeting
Event date： 2024.4.6 - 2024.4.7
Language：Japanese Presentation type：Oral presentation (general)
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On the evolutionary scenario of Strongyloides spp. of primates: discovery of a novel member in the stercoralis-procyonis clade in Gabon International coauthorship
Eiji Nagayasu, Patrice Makouloutou Nzassi, Larson Boundenga, Haruhiko Maruyama
第93回日本寄生虫学会大会 2024.3
Event date： 2024.3.9 - 2024.3.10
Language：Japanese Presentation type：Oral presentation (general)
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Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice
Setia Yulia Dwi, 田中 美緒, 田中 龍聖, 長安 英治, Parinian Ahmadi, 入江 隆夫, 吉田 彩子, 丸山 治彦
第93回日本寄生虫学会大会 2024.3
Event date： 2024.3.9 - 2024.3.10
Language：English Presentation type：Poster presentation
Grant-in-Aid for Scientific Research 【 display / non-display 】
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ネコ型亜目動物寄生性糞線虫の多様性・系統関係・異種宿主間感染に関する実態解明調査
Grant number：25K10336 2025.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator
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Elucidation of pathophysiology of proliferative sparganosis-like Spirometra infection by whole genome re-sequencing and expression profiling of infecting worms
Grant number：24K10192 2024.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Coinvestigator(s)
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寄生虫の分子同定と系統解析のための統一標準法の確立
Grant number：21H02725 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
丸山 治彦、長安 英治
Authorship：Coinvestigator(s)
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ヒト糞線虫の起源：アジア、アフリカ、南米の霊長類を中心としたサンプリングから
Grant number：20K07464 2020.04 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator
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Investigation of seroprevalence and transmission routes for Paragonimus westermani infection in sika deer
Grant number：17K08082 2017.04 - 2020.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Yoshida Ayako
Authorship：Coinvestigator(s)
Seroprevalence of Paragonimus infection in sika deer was evaluated to assess the risk of paragonimiasis through venison consumption. Total 1,546 blood samples collected from sika deer from February 2013 to March 2020 in western Japan were tested by pre-adsorbed ELISA, and 1.4 % of them were positive for anti-Paragonimus antibodies. Our results suggested that venison can be a risk of the infection in the endemic areas of paragonimiasis, although the infection risk of venison would be lower than that of wild boar meat considering the positive rate in wild boars in these areas (9.1-43.0%). In addition, the leg of Japanese freshwater crab, Geothelphusa dehaani, was found in the rumen of sika deer, suggesting sika deer got Paragonimus infection by the ingestion of Japanese freshwater crab, the first intermediate host.
Other research activities 【 display / non-display 】
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ミャンマーにおける糞線虫症フィールド調査
2015.01
ミャンマーにおける糞線虫症のフィールド調査
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ウガンダにおける寄生虫症フィールドワーク
2014.10 - 2014.11
ウガンダにおけるフィラリア症の流行状況の調査
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ウガンダにおける寄生虫症フィールドワーク
2014.05
ウガンダにおけるマラリア感染者及び非感染者における腸内細菌叢の解析
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ミャンマーにおける寄生虫症共同研究
2014.01 - 2014.02
University of Medicine (1), Yangonにおける寄生虫症に関するセミナー及び共同研究の実施
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ウガンダにおける寄生虫症フィールドワーク
2013.10 - 2013.11
Gulu大学との国際共同研究