UMEKITA Kunihiko

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Internal Medicine, Hematology, Respirology, Rheumatology, Infectious Diseases, and Neurology

Title

Associate Professor

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Degree 【 display / non-display

  • 博士(医学) ( 2009.5   宮崎大学 )

  • 学士(医学) ( 2002.3   宮崎医科大学 )

Research Areas 【 display / non-display

  • Life Science / Connective tissue disease and allergy

 

Papers 【 display / non-display

  • Seroprevalence of severe fever with thrombocytopenia syndrome virus in medium-sized wild mammals in Miyazaki, Japan Reviewed

    Kaneko C., Mekata H., Umeki K., Sudaryatma P.E., Irie T., Yamada K., Misawa N., Umekita K., Okabayashi T.

    Ticks and Tick-borne Diseases   14 ( 2 )   102115   2023.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Ticks and Tick-borne Diseases  

    Severe fever with thrombocytopenia syndrome (SFTS) is a fatal emerging tick-borne zoonotic disease caused by the SFTS virus (SFTSV). SFTSV infection in humans and companion animals is a matter of concern in endemic areas. Various wild animals are involved in the transmission cycle of SFTSV with vector ticks. Because the home range of medium-sized wild mammals commonly overlaps with humans’ living spheres, this study aimed to reveal the endemicity of SFTSV in such mammals. This study investigated the prevalence of antibodies against SFTSV and viral RNA in medium-sized wild mammals in Miyazaki Prefecture, Japan where human cases have been most frequently reported in Japan and performed a phylogenetic analysis to compare the detected SFTSV with those previously reported. Forty-three of 63 (68%) Japanese badgers (Meles anakuma) and 12 of 53 (23%) Japanese raccoon dogs (Nyctereutes procyonoides viverrinus) had antibodies against SFTSV. Japanese marten (n = 1), weasels (n = 4), and Japanese red fox (n = 1) were negative. Two of 63 (3%) badgers tested positive for SFTSV RNA, whereas the other species were negative. Phylogenetic analysis of the partial nucleotide sequence of SFTSV revealed that viral RNA detected from badgers exhibited 99.8% to 100% similarity to SFTSV, as previously reported in humans, cat, and ticks in the study area. This study demonstrated high seropositivity of antibodies in medium-sized wild mammals and suggested that SFTSV could be shared among these mammals, humans, and companion animals in endemic areas.

    DOI: 10.1016/j.ttbdis.2022.102115

    Scopus

    PubMed

  • Nosocomial Severe Fever with Thrombocytopenia Syndrome in Companion Animals, Japan, 2022 Reviewed

    Mekata H., Umeki K., Yamada K., Umekita K., Okabayashi T.

    Emerging Infectious Diseases   29 ( 3 )   614 - 617   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Emerging Infectious Diseases  

    In Japan, 2 cats that underwent surgery in a room where a sick dog had been euthanized became ill within 9 days of surgery. Severe fever with thrombocytopenia syndrome virus was detected in all 3 animals; nucleotide sequence identity was 100%. Suspected cause was an uncleaned pulse oximeter probe used for all patients.

    DOI: 10.3201/eid2903.220720

    Scopus

  • HAS-Flow May Be an Adequate Method for Evaluating Human T-Cell Leukemia Virus Type 1 Infected Cells in Human T-Cell Leukemia Virus Type 1-Positive Rheumatoid Arthritis Patients Receiving Antirheumatic Therapies: A Retrospective Cross-Sectional Observation Study Reviewed

    Umekita K., Hashikura Y., Takaki A., Kimura M., Kawano K., Iwao C., Miyauchi S., Kawaguchi T., Matsuda M., Hashiba Y., Hidaka T.

    Viruses   15 ( 2 )   2023.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Viruses  

    The study aims to assess the usefulness of human T-cell leukemia virus type 1 (HTLV-1)-infected cell analysis using flow cytometry (HAS-Flow) as a monitoring method for adult T-cell leukemia (ATL) development in HTLV-1-positive patients with rheumatoid arthritis (RA) under treatment with antirheumatic therapies. A total of 13 HTLV-1-negative and 57 HTLV-1-positive RA patients participated in this study, which was used to collect clinical and laboratory data, including HAS-Flow and HTLV-1 proviral load (PVL), which were then compared between the two groups. CADM1 expression on CD4+ cells in peripheral blood (PB) was used to identify HTLV-1-infected cells. The population of CADM1+ CD4+ cells was significantly higher in HTLV-1-positive RA patients compared to HTLV-1-negative RA patients. The population of CADM1+ CD4+ cells was correlated with HTLV-1 PVL values. There were no antirheumatic therapies affecting both the expression of CADM1 on CD4+ cells and PVLs. Six HTLV-1-positive RA patients who indicated both high HTLV-1 PVL and a predominant pattern of CADM1+ CD7neg CD4+ cells in HAS-Flow can be classified as high-risk for ATL progression. HAS-Flow could be a useful method for monitoring high-risk HTLV-1-positive RA patients who are at risk of developing ATL during antirheumatic therapies.

    DOI: 10.3390/v15020468

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    PubMed

  • Possible transmission of severe fever with thrombocytopenia syndrome virus (SFTSV) to a person who buried the corpus of a dead cat, which died of SFTSV infection Reviewed

    Mekata Hirohisa, Kawaguchi Takeshi, Iwao Kosho, Umeki Kazumi, Yamada Kentaro, Umekita Kunihiko, Okabayashi Tamaki

    Japanese Journal of Infectious Diseases   advpub ( 0 )   211 - 214   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:National Institute of Infectious Diseases  

    Severe fever with thrombocytopenia syndrome (SFTS) is caused by the severe fever with thrombocytopenia syndrome virus (SFTSV). Although SFTS is a fatal tick-borne zoonosis, it can infect humans without tick bite exposure. Recently, direct transmission of SFTSV from companion pets to humans has become a major problem. We present a case of SFTSV transmission from a dead community cat to a woman who buried the cat in Miyazaki Prefecture, Japan. The community cat died without a diagnosis of SFTS, and the woman buried it without taking any precautions. She developed symptoms of SFTS 9 days later. The woman tested positive for SFTS viral RNA and anti-SFTSV antibodies. The cat’s carcass was exhumed, and tissue samples were collected to confirm the viral infection. Numerous copies of viral RNA were detected. The SFTSV M segment sequences in the cat and the woman were 100% homologous. The woman claimed that she had touched blood that had leaked from the cat’s body while burying it. However, she could have been infected while transporting the cat to the animal hospital. This study highlights the risk of SFTSV infection from contact with sick or dead community cats.

    DOI: 10.7883/yoken.JJID.2022.425

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    CiNii Research

  • High incidence of serious infections requiring hospitalisation in human T-cell leukaemia virus type 1-positive rheumatoid arthritis: A case-controlled observational study. Reviewed International journal

    Yayoi Hashiba, Kunihiko Umekita, Masatoshi Kimura, Chihiro Iwao, Kosho Iwao, Yumi Kariya, Kazuyoshi Kubo, Shunichi Miyauchi, Risa Kudou, Yuki Rikitake, Takeshi Kawaguchi, Motohiro Matsuda, Ichiro Takajo, Eisuke Inoue, Toshihiko Hidaka, Akihiko Okayama

    Modern rheumatology   32 ( 5 )   866 - 874   2022.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: We aimed to assess the clinical features of human T-cell leukaemia virus type 1 (HTLV-1)-positive rheumatoid arthritis (RA) patients. Furthermore, we investigated the impact of HTLV-1 infection on incidences of serious infections requiring hospitalisation (SIH) and malignancies. METHODS: A total of 150 sex- and age-matched HTLV-1-negative and 50 HTLV-1-positive RA patients were enrolled from the HTLV-1 RA Miyazaki Cohort Study. Clinical and laboratory data were collected from this cohort database. The incidence rate (IR) for SIH and malignancies from 2015 to 2020 was analysed. RESULTS: The median age and female ratio in the study population were 70 years old and 80%, respectively. Although no differences were found in inflammatory marker values between the two groups, the patient global assessment and Health Assessment Questionnaire scores were higher in HTLV-1-positive RA patients. In HTLV-1-negative RA patients, the IR for SIH was 6.37/100 person-years (PY) and 1.32/100 PY for malignancies. In HTLV-1-positive RA patients, SIH occurred in 11.1/100 PY and malignancies in 2.46/100 PY. The crude IR ratio comparing SIH between two groups was 1.74 (95% confidence interval, 1.04-2.84), which was a significant increase. CONCLUSIONS: HTLV-1-positive RA patients may worsen RA symptoms. HTLV-1 may be a risk factor for SIH.

    DOI: 10.1093/mr/roab077

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Books 【 display / non-display

  • がんの臨床検査ハンドブック.

    梅北邦彦, 岡山昭彦.( Role: Joint author ,  1章 がんと日常的検査 5 がん関連ウイルス検査.)

    日本医事新報社.  2019.1 

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    Language:Japanese Book type:Scholarly book

  • 膠原病・リウマチ・アレルギー 研修ノート.

    梅北邦彦, 岡山昭彦.( Role: Contributor ,  第3章 診察と検査の手技を学ぶ B. 一般臨床検査 2. 末梢血.)

    診断と治療社  2016.4 

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    Language:Japanese Book type:Scholarly book

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  • Effect of HTLV-1 Infection on the Clinical Course of Patients with Rheumatoid Arthritis. Reviewed

    Umekita K.

    Viruses   14 ( 7 )   1460   2022.7

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 最新関節リウマチ学(第2 版 ―寛解・治癒を目指した研究と最新治療― V.関節リウマチの臓器障害と合併症・薬剤副作用対策 感染症(薬剤性日和見感染症を含む) 

    梅北邦彦、岡山昭彦

    日本臨牀   80 ( 4 )   614 - 619   2022.4

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  • 最新関節リウマチ学(第2 版 ―寛解・治癒を目指した研究と最新治療― V.関節リウマチの臓器障害と合併症・薬剤副作用対策 感染症(薬剤性日和見感染症を含む) 

    梅北邦彦、岡山昭彦

    最新関節リウマチ学(第2 版 ―寛解・治癒を目指した研究と最新治療― V.関節リウマチの臓器障害と合併症・薬剤副作用対策 感染症(薬剤性日和見感染症を含む)    2022.4

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  • 免疫・炎症疾患のすべて VI免疫・炎症疾患各論/病原微生物・新生物に惹起される免疫疾患ヒトT細胞白血病ウイルス1型(HTLV-1).

    梅北邦彦, 岡山昭彦.

    免疫・炎症疾患のすべて VI免疫・炎症疾患各論/病原微生物・新生物に惹起される免疫疾患ヒトT細胞白血病ウイルス1型(HTLV-1).   2020.10

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  • 特集 HTLV-1母子感染をもっと知ろう HTLV-関連疾患 ATL,HAM以外の関連疾患.

    梅北邦彦, 岡山昭彦.

    特集 HTLV-1母子感染をもっと知ろう HTLV-関連疾患 ATL,HAM以外の関連疾患.   2020.10

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Presentations 【 display / non-display

  • 重症熱性血小板減少症候群(SFTS)に侵襲性肺アスペルギルス症が合併した 1 剖検例

    住吉誠、木村賢俊、力武雄幹、岩尾千紘、力武真央、岩尾浩昭、仮屋裕美、川口剛、 松田基弘、宮内俊一、梅北邦彦、髙城一郎、宮崎泰可

    第89回九州真菌懇話会・第4回日本医真菌学会九州・中四国支部会 

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    Event date: 2022.7.31

    Presentation type:Oral presentation (general)  

  • Immunological response to anti-SARS-CoV-2 mRNA vaccines in patients with rheumatoid arthritis

    Kazuko Yamamoto, Tomohiro Koga, Kunihiro Ichinose, Remi Sumiyoshi, Shota Kurushima, Toshimasa Shimizu, Tohru Michitsuji, Toshika Tsuji, Shinya Nishihata, Naoki Iwamoto, Masataka Umeda, Tomoki Origuchi, Mami Tamai Akitomo Okada, Masako Furuyama, Kunihiko Umekita, Yuya Fuujita, Kiyoshi Migita, Atsushi Kawakami, Hiroshi Mukae

    International Concurrent Workshop 

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    Event date: 2022.4.25 - 2022.4.27

    Presentation type:Oral presentation (general)  

  • 低用量ステロイド治療が継続可能であったあ皮膚筋炎/多発性筋炎の臨床的特徴

    木村賢俊、相澤彩子、工藤理紗、力武雄幹、岩尾千紘、力武真央、岩尾浩昭、仮屋裕美、川口剛、松田基弘、宮内俊一、髙城一郎、梅北邦彦

    第66回日本リウマチ学会総会・学術集会 

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    Event date: 2022.4.25 - 2022.4.27

    Presentation type:Oral presentation (general)  

  • ヒトT細胞白血病ウイルス1型(HTLV-1)陽性関節リウマチにおけるHTLV-1感染細胞のフローサイトメトリーによる評価方法の検討.

    梅北邦彦,高木 覚,橋倉悠輝

    第68回日本臨床検査医学会学術集会.  

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    Event date: 2021.11.11 - 2021.11.14

    Presentation type:Oral presentation (general)  

  • ヒトT細胞白血病ウイルス1型感染細胞由来のエクソソーム精製におけるウイルス粒子分離排除法の検討.

    河野克海,橋倉悠輝,梅北邦彦,岡山昭彦

    第7回日本HTLV-1学会学術集会.  

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    Event date: 2021.11.5 - 2021.11.7

    Presentation type:Oral presentation (general)  

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Awards 【 display / non-display

  • 西日本地方会「感染症優秀論文賞」

    2020.10   日本感染症学会   Human T-cell Leukemia Virus Type 1 May Invalidate T-SPOT. TB Assay Results in Rheumatoid Arthritis Patients: A Retrospective Case-Control Observational Study.

    梅北邦彦

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • International Concurrent Workshop

    2015.4  

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  • JCR-EULAR Young Rheumatologist Training Program

    2012.6  

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    Country:Japan

  • 平成24年度海外派遣研修医

    2012.5   日本リウマチ財団  

    梅北邦彦

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    Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • HAMならびに類縁疾患の患者レジストリによる診療連携体制および相談機能の強化と診療ガイドラインの改訂

    Grant number:22FC1013  2022.04 - 2025.03

    厚生労働省  厚生科研  難治性疾患政策研究事業

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    Authorship:Coinvestigator(s) 

  • 治療抵抗性関節リウマチ患者におけるHTLV-1感染の影響

    Grant number:26860754  2014.04 - 2017.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

    治療抵抗性関節リウマチ患者におけるHTLV-1感染の影響

  • 重症熱性血小板減少症候群における血小板減少と血液凝固異常の病態解明

    Grant number:23K06425  2023.04 - 2026.03

    独立行政法人日本学術振興会  科学研究費基金  基盤研究(C)

    盛口 清香

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    Authorship:Coinvestigator(s) 

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