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Affiliation |
Faculty of Medicine School of Medicine Department of Internal Medicine, Hematology, Respirology, Rheumatology, Infectious Diseases, and Neurology |
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Associate Professor |
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External Link |
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UMEKITA Kunihiko
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Degree 【 display / non-display 】
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博士（医学） ( 2009.5 宮崎大学 )
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学士（医学） ( 2002.3 宮崎医科大学 )
Research Areas 【 display / non-display 】
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Life Science / Connective tissue disease and allergy
Papers 【 display / non-display 】
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Kaneko C., Mekata H., Umeki K., Sudaryatma P.E., Irie T., Yamada K., Misawa N., Umekita K., Okabayashi T.
Ticks and Tick-borne Diseases 14 ( 2 ) 102115 2023.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Ticks and Tick-borne Diseases
Severe fever with thrombocytopenia syndrome (SFTS) is a fatal emerging tick-borne zoonotic disease caused by the SFTS virus (SFTSV). SFTSV infection in humans and companion animals is a matter of concern in endemic areas. Various wild animals are involved in the transmission cycle of SFTSV with vector ticks. Because the home range of medium-sized wild mammals commonly overlaps with humans’ living spheres, this study aimed to reveal the endemicity of SFTSV in such mammals. This study investigated the prevalence of antibodies against SFTSV and viral RNA in medium-sized wild mammals in Miyazaki Prefecture, Japan where human cases have been most frequently reported in Japan and performed a phylogenetic analysis to compare the detected SFTSV with those previously reported. Forty-three of 63 (68%) Japanese badgers (Meles anakuma) and 12 of 53 (23%) Japanese raccoon dogs (Nyctereutes procyonoides viverrinus) had antibodies against SFTSV. Japanese marten (n = 1), weasels (n = 4), and Japanese red fox (n = 1) were negative. Two of 63 (3%) badgers tested positive for SFTSV RNA, whereas the other species were negative. Phylogenetic analysis of the partial nucleotide sequence of SFTSV revealed that viral RNA detected from badgers exhibited 99.8% to 100% similarity to SFTSV, as previously reported in humans, cat, and ticks in the study area. This study demonstrated high seropositivity of antibodies in medium-sized wild mammals and suggested that SFTSV could be shared among these mammals, humans, and companion animals in endemic areas.
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Nosocomial Severe Fever with Thrombocytopenia Syndrome in Companion Animals, Japan, 2022 Reviewed
Mekata H., Umeki K., Yamada K., Umekita K., Okabayashi T.
Emerging Infectious Diseases 29 ( 3 ) 614 - 617 2023.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Emerging Infectious Diseases
In Japan, 2 cats that underwent surgery in a room where a sick dog had been euthanized became ill within 9 days of surgery. Severe fever with thrombocytopenia syndrome virus was detected in all 3 animals; nucleotide sequence identity was 100%. Suspected cause was an uncleaned pulse oximeter probe used for all patients.
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Umekita K., Hashikura Y., Takaki A., Kimura M., Kawano K., Iwao C., Miyauchi S., Kawaguchi T., Matsuda M., Hashiba Y., Hidaka T.
Viruses 15 ( 2 ) 2023.2
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Viruses
The study aims to assess the usefulness of human T-cell leukemia virus type 1 (HTLV-1)-infected cell analysis using flow cytometry (HAS-Flow) as a monitoring method for adult T-cell leukemia (ATL) development in HTLV-1-positive patients with rheumatoid arthritis (RA) under treatment with antirheumatic therapies. A total of 13 HTLV-1-negative and 57 HTLV-1-positive RA patients participated in this study, which was used to collect clinical and laboratory data, including HAS-Flow and HTLV-1 proviral load (PVL), which were then compared between the two groups. CADM1 expression on CD4+ cells in peripheral blood (PB) was used to identify HTLV-1-infected cells. The population of CADM1+ CD4+ cells was significantly higher in HTLV-1-positive RA patients compared to HTLV-1-negative RA patients. The population of CADM1+ CD4+ cells was correlated with HTLV-1 PVL values. There were no antirheumatic therapies affecting both the expression of CADM1 on CD4+ cells and PVLs. Six HTLV-1-positive RA patients who indicated both high HTLV-1 PVL and a predominant pattern of CADM1+ CD7neg CD4+ cells in HAS-Flow can be classified as high-risk for ATL progression. HAS-Flow could be a useful method for monitoring high-risk HTLV-1-positive RA patients who are at risk of developing ATL during antirheumatic therapies.
DOI： 10.3390/v15020468
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Mekata Hirohisa, Kawaguchi Takeshi, Iwao Kosho, Umeki Kazumi, Yamada Kentaro, Umekita Kunihiko, Okabayashi Tamaki
Japanese Journal of Infectious Diseases advpub ( 0 ) 211 - 214 2023.1
Language：English Publishing type：Research paper (scientific journal) Publisher：National Institute of Infectious Diseases
Severe fever with thrombocytopenia syndrome (SFTS) is caused by the severe fever with thrombocytopenia syndrome virus (SFTSV). Although SFTS is a fatal tick-borne zoonosis, it can infect humans without tick bite exposure. Recently, direct transmission of SFTSV from companion pets to humans has become a major problem. We present a case of SFTSV transmission from a dead community cat to a woman who buried the cat in Miyazaki Prefecture, Japan. The community cat died without a diagnosis of SFTS, and the woman buried it without taking any precautions. She developed symptoms of SFTS 9 days later. The woman tested positive for SFTS viral RNA and anti-SFTSV antibodies. The cat’s carcass was exhumed, and tissue samples were collected to confirm the viral infection. Numerous copies of viral RNA were detected. The SFTSV M segment sequences in the cat and the woman were 100% homologous. The woman claimed that she had touched blood that had leaked from the cat’s body while burying it. However, she could have been infected while transporting the cat to the animal hospital. This study highlights the risk of SFTSV infection from contact with sick or dead community cats.
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High incidence of serious infections requiring hospitalisation in human T-cell leukaemia virus type 1-positive rheumatoid arthritis: A case-controlled observational study. Reviewed International journal
Yayoi Hashiba, Kunihiko Umekita, Masatoshi Kimura, Chihiro Iwao, Kosho Iwao, Yumi Kariya, Kazuyoshi Kubo, Shunichi Miyauchi, Risa Kudou, Yuki Rikitake, Takeshi Kawaguchi, Motohiro Matsuda, Ichiro Takajo, Eisuke Inoue, Toshihiko Hidaka, Akihiko Okayama
Modern rheumatology 32 ( 5 ) 866 - 874 2022.9
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
OBJECTIVES: We aimed to assess the clinical features of human T-cell leukaemia virus type 1 (HTLV-1)-positive rheumatoid arthritis (RA) patients. Furthermore, we investigated the impact of HTLV-1 infection on incidences of serious infections requiring hospitalisation (SIH) and malignancies. METHODS: A total of 150 sex- and age-matched HTLV-1-negative and 50 HTLV-1-positive RA patients were enrolled from the HTLV-1 RA Miyazaki Cohort Study. Clinical and laboratory data were collected from this cohort database. The incidence rate (IR) for SIH and malignancies from 2015 to 2020 was analysed. RESULTS: The median age and female ratio in the study population were 70 years old and 80%, respectively. Although no differences were found in inflammatory marker values between the two groups, the patient global assessment and Health Assessment Questionnaire scores were higher in HTLV-1-positive RA patients. In HTLV-1-negative RA patients, the IR for SIH was 6.37/100 person-years (PY) and 1.32/100 PY for malignancies. In HTLV-1-positive RA patients, SIH occurred in 11.1/100 PY and malignancies in 2.46/100 PY. The crude IR ratio comparing SIH between two groups was 1.74 (95% confidence interval, 1.04-2.84), which was a significant increase. CONCLUSIONS: HTLV-1-positive RA patients may worsen RA symptoms. HTLV-1 may be a risk factor for SIH.
DOI： 10.1093/mr/roab077
Books 【 display / non-display 】
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がんの臨床検査ハンドブック.
梅北邦彦, 岡山昭彦.（ Role： Joint author , 1章 がんと日常的検査 5 がん関連ウイルス検査.）
日本医事新報社. 2019.1
Language：Japanese Book type：Scholarly book
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膠原病・リウマチ・アレルギー 研修ノート.
梅北邦彦, 岡山昭彦.（ Role： Contributor , 第３章 診察と検査の手技を学ぶ B. 一般臨床検査 ２. 末梢血.）
診断と治療社 2016.4
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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Effect of HTLV-1 Infection on the Clinical Course of Patients with Rheumatoid Arthritis. Reviewed
Umekita K.
Viruses 14 ( 7 ) 1460 2022.7
Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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最新関節リウマチ学(第2 版 ―寛解・治癒を目指した研究と最新治療― V．関節リウマチの臓器障害と合併症・薬剤副作用対策 感染症(薬剤性日和見感染症を含む)
梅北邦彦、岡山昭彦
日本臨牀 80 ( 4 ) 614 - 619 2022.4
Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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最新関節リウマチ学(第2 版 ―寛解・治癒を目指した研究と最新治療― V．関節リウマチの臓器障害と合併症・薬剤副作用対策 感染症(薬剤性日和見感染症を含む)
梅北邦彦、岡山昭彦
最新関節リウマチ学(第2 版 ―寛解・治癒を目指した研究と最新治療― V．関節リウマチの臓器障害と合併症・薬剤副作用対策 感染症(薬剤性日和見感染症を含む) 2022.4
Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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免疫・炎症疾患のすべて VI免疫・炎症疾患各論／病原微生物・新生物に惹起される免疫疾患ヒトT細胞白血病ウイルス1型(HTLV-1).
梅北邦彦, 岡山昭彦.
免疫・炎症疾患のすべて VI免疫・炎症疾患各論／病原微生物・新生物に惹起される免疫疾患ヒトT細胞白血病ウイルス1型(HTLV-1). 2020.10
Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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特集 HTLV-1母子感染をもっと知ろう HTLV-関連疾患 ATL,HAM以外の関連疾患.
梅北邦彦, 岡山昭彦.
特集 HTLV-1母子感染をもっと知ろう HTLV-関連疾患 ATL,HAM以外の関連疾患. 2020.10
Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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重症熱性血小板減少症候群（SFTS）に侵襲性肺アスペルギルス症が合併した 1 剖検例
住吉誠、木村賢俊、力武雄幹、岩尾千紘、力武真央、岩尾浩昭、仮屋裕美、川口剛、 松田基弘、宮内俊一、梅北邦彦、髙城一郎、宮崎泰可
第89回九州真菌懇話会・第4回日本医真菌学会九州・中四国支部会
Event date： 2022.7.31
Presentation type：Oral presentation (general)
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Immunological response to anti-SARS-CoV-2 mRNA vaccines in patients with rheumatoid arthritis
Kazuko Yamamoto, Tomohiro Koga, Kunihiro Ichinose, Remi Sumiyoshi, Shota Kurushima, Toshimasa Shimizu, Tohru Michitsuji, Toshika Tsuji, Shinya Nishihata, Naoki Iwamoto, Masataka Umeda, Tomoki Origuchi, Mami Tamai Akitomo Okada, Masako Furuyama, Kunihiko Umekita, Yuya Fuujita, Kiyoshi Migita, Atsushi Kawakami, Hiroshi Mukae
International Concurrent Workshop
Event date： 2022.4.25 - 2022.4.27
Presentation type：Oral presentation (general)
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低用量ステロイド治療が継続可能であったあ皮膚筋炎/多発性筋炎の臨床的特徴
木村賢俊、相澤彩子、工藤理紗、力武雄幹、岩尾千紘、力武真央、岩尾浩昭、仮屋裕美、川口剛、松田基弘、宮内俊一、髙城一郎、梅北邦彦
第66回日本リウマチ学会総会・学術集会
Event date： 2022.4.25 - 2022.4.27
Presentation type：Oral presentation (general)
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ヒトT細胞白血病ウイルス1型（HTLV-1）陽性関節リウマチにおけるHTLV-1感染細胞のフローサイトメトリーによる評価方法の検討.
梅北邦彦，高木 覚，橋倉悠輝
第68回日本臨床検査医学会学術集会.
Event date： 2021.11.11 - 2021.11.14
Presentation type：Oral presentation (general)
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ヒトT細胞白血病ウイルス1型感染細胞由来のエクソソーム精製におけるウイルス粒子分離排除法の検討．
河野克海，橋倉悠輝，梅北邦彦，岡山昭彦
第7回日本HTLV-1学会学術集会.
Event date： 2021.11.5 - 2021.11.7
Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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西日本地方会「感染症優秀論文賞」
2020.10 日本感染症学会 Human T-cell Leukemia Virus Type 1 May Invalidate T-SPOT. TB Assay Results in Rheumatoid Arthritis Patients: A Retrospective Case-Control Observational Study.
梅北邦彦
Award type：Award from Japanese society, conference, symposium, etc.
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International Concurrent Workshop
2015.4
Award type：Award from international society, conference, symposium, etc. Country：Japan
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JCR-EULAR Young Rheumatologist Training Program
2012.6
Country：Japan
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平成24年度海外派遣研修医
2012.5 日本リウマチ財団
梅北邦彦
Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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HAMならびに類縁疾患の患者レジストリによる診療連携体制および相談機能の強化と診療ガイドラインの改訂
Grant number：22FC1013 2022.04 - 2025.03
厚生労働省 厚生科研 難治性疾患政策研究事業
Authorship：Coinvestigator(s)
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治療抵抗性関節リウマチ患者におけるHTLV-1感染の影響
Grant number：26860754 2014.04 - 2017.03
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
治療抵抗性関節リウマチ患者におけるHTLV-1感染の影響
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重症熱性血小板減少症候群における血小板減少と血液凝固異常の病態解明
Grant number：23K06425 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
盛口 清香
Authorship：Coinvestigator(s)
Available Technology 【 display / non-display 】
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ヒトT細胞白血病ウイルス1型陽性膠原病リウマチ性疾患のレジストリ研究
重症熱性血小板減少症（SFTS）を主としたダニ媒介感染症の診断・治療の開発
新興・再興感染症の研究推進に資するバイオリソースの構築Message：共同研究の希望テーマ：ウイルス感染症の迅速診断試薬の共同開発，抗炎症物質の探索による膠原病リウマチ性疾患およびウイルス感染症の新規治療薬の開発