AKIEDA Sayaka

写真a

Affiliation

Frontier Science Research Center Life science field of inquiry physiology activator function analysis field

Title

Associate Professor

External Link

Degree 【 display / non-display

  • 博士(獣医学) ( 2005.3   岐阜大学 )

 

Papers 【 display / non-display

  • Maternal traits during lactation period reduce the anxiety-related behavior in male offspring: Results from a fostering study in hatano rats Reviewed

    Horii Y, Nakajima S, Akieda-Asai S, Ohta R, Kawaguchi M

    Physiol Behav   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.physbeh.2020.113209

  • Palmitic acid induces guanylin gene expression through the Toll-like receptor 4/nuclear factor-κB pathway in rat macrophages.

    Akieda-Asai S, Ma H, Date Y

    American journal of physiology. Cell physiology   317 ( 6 )   C1239 - C1246   2019.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpcell.00081.2019

    PubMed

  • Influence of food texture on energy metabolism and adiposity in male rats. Reviewed

    Han W, Utoyoma M, Akieda-Asai S, Hidaka A, Yamada C, Hasegawa K, Nunoi H, Date Y

    Exp Physiol   103 ( 10 )   1347 - 1356   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/EP087072

  • Interleukin-15 derived from Guanylin–GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes Reviewed

    Akieda-Asai S., Ida T., Miyazato M., Kangawa K., Date Y.

    Peptides   99   14 - 19   2018.1

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Peptides  

    Recently we found that guanylin (Gn) and its receptor, guanylyl cyclase C (GC-C), are uniquely expressed in the mesenteric macrophages of some diet-resistant rats and that double-transgenic (dTg) rats overexpressing Gn and GC-C in macrophages demonstrate reduced fatty acid synthase and fat accumulation in fat tissue even when fed a high-fat diet (HFD). Lipid accumulation and fatty acid synthase mRNA levels in cocultured dTg rat adipocytes and macrophages were reduced compared with those in adipocytes cultured with WT rat macrophages. Here, we investigated whether Interleukin-15 (IL-15) derived from Gn–GC-C-expressing macrophages regulates lipid accumulation in adipocytes. IL-15 inhibited fatty acid synthase and lipid accumulation via STAT5 in cultured adipocytes. IL-15 mRNA and protein levels in the mesenteric fat of HFD-fed dTg rats were significantly higher than those of HFD-fed WT rats. Phosphorylated STAT5 levels in the mesenteric fat of HFD-fed dTg rats were increased compared with those of HFD-fed WT rats. In addition, the mRNA level of fatty acid synthase in the mesenteric fat was lower in HFD-fed dTg rats than in HFD-fed WT rats. These results support the hypothesis that IL-15 secreted from Gn–GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance.

    DOI: 10.1016/j.peptides.2017.10.012

    Scopus

  • Guanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue. Reviewed

    Yasuda M, Kawabata J, Akieda-Asai S, Nasu T, Date Y

    J Vet Sci.   18 ( 3 )   341 - 348   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.4142/jvs.2017.18.3.341.

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MISC 【 display / non-display

  • 糖尿病と食物性状の関わり Invited

    秋枝さやか

    DITN   2017.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

  • Cross-talk of periphery with central in feeding behavior.

    Sayaka Akieda, Yukari Date.

    Kagaku To Seibutsu   47 ( 11 )   750 - 755   2009.11

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)   Publisher:Japan Scientific Societies Press  

  • Development of imaging mass spectrometry

    Sayaka Asai, Mitsutoshi Setou.

    Gendaikagaku   434   51 - 55   2007.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:Tokyo Kagaku Dojin  

Presentations 【 display / non-display

  • 軟食摂取による腸内細菌叢の変化

    秋枝さやか, 伊達紫

    第11回ペプチド・ホルモン研究会  軟食摂取による腸内細菌叢の変化

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    Event date: 2020.12.5

    Language:Japanese   Presentation type:Oral presentation (general)  

  • グアニリン・グアニル酸シクラーゼC発現マクロファージ由来のIL-15による脂肪蓄積抑制機構 International conference

    秋枝さやか, 伊達紫

    第40回日本肥満学会 

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    Event date: 2019.11.2

    Language:Japanese  

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  • Influence of food texture on energy metabolism and adiposity in male rats. International conference

    Influence of food texture on energy metabolism and adiposity in male rats. 

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    Event date: 2018.8.18

    Language:Japanese  

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  • グアニリンおよびグアニル酸シクラーゼC高発現マクロファージ由来のIL-15は脂肪細胞の脂肪酸合成を抑制する International conference

    秋枝さやか, 井田隆徳, 宮里幹也, 伊達紫

    第91回日本内分泌学会 

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    Event date: 2018.4.28

    Language:Japanese  

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  • 農と食の未来を切り拓け!ホルモン研究-「食物の性状が糖代謝や脂質代謝に及ぼす影響」 Invited

    秋枝さやか, 伊達紫

    ConBio2017 

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    Event date: 2017.12.6 - 2017.12.8

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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Awards 【 display / non-display

  • 2016年度 ひと・健康・未来財団 助成研究発表会 優秀賞 食品分野

    2016.11   公益財団法人ひと・健康・未来財団  

    秋枝さやか

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

  • 第155回日本獣医学会大会長賞受賞

    2013.3   日本獣医学会  

    秋枝さやか

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 宮崎大学女性研究者奨励賞(研究部門)

    2013.3   宮崎大学  

    秋枝さやか

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    Country:Japan

  • コスモ・バイオ学術論文賞

    2012.12   コスモ・バイオ株式会社  

    J Lipid Res, 2013 論文

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    Country:Japan

  • 第17回日本下垂体研究会, 優秀ポスター賞

    2002.8   日本下垂体研究会  

    浅井さやか

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • 肥満のない2型糖尿病の発症と進展機序の解明

    Grant number:22K11806  2022.04 - 2025.03

    科学研究費補助金  科学研究費 基盤研究(C)

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    Authorship:Principal investigator 

  • 軟らかい食べ物が招く生活習慣病の発症機序に関する研究

    Grant number:22H00952  2022.04 - 2025.03

    科学研究費補助金  科学研究費 基盤研究(B)

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    Authorship:Coinvestigator(s) 

  • 日本人型糖尿病モデルラットの軟食飼育が糖尿病と咀嚼器官の発達と老化に及ぼす影響

    Grant number:17K01905  2017.04 - 2020.03

    科学研究費補助金  基盤研究(C)

  • マクロファージのグアニリンとその受容体によるエネルギー代謝調節機構の解明

    2016.04 - 2019.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • マクロファージ由来の生理活性物質による脂肪蓄積制御機構の解明

    2014.04 - 2016.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

    マクロファージ由来の生理活性物質による脂肪蓄積制御機構の解明

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