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Affiliation |
Frontier Science Research Center Life science field of inquiry physiology activator function analysis field |
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Associate Professor |
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External Link |
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AKIEDA Sayaka
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Papers 【 display / non-display 】
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Mechanism of muscle atrophy in a normal-weight rat model of type 2 diabetes established by using a soft-pellet diet Reviewed International coauthorship
Sayaka Akieda-Asai, Hao Ma, Wanxin Han, Junko Nagata, Fumitake Yamaguchi, Yukari Date
Scientific Reports 2024
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Maternal traits during lactation period reduce the anxiety-related behavior in male offspring: Results from a fostering study in hatano rats Reviewed
Horii Y, Nakajima S, Akieda-Asai S, Ohta R, Kawaguchi M
Physiol Behav 2020
Language：English Publishing type：Research paper (scientific journal)
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Palmitic acid induces guanylin gene expression through the Toll-like receptor 4/nuclear factor-κB pathway in rat macrophages.
Akieda-Asai S, Ma H, Date Y
American journal of physiology. Cell physiology 317 ( 6 ) C1239 - C1246 2019.12
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Influence of food texture on energy metabolism and adiposity in male rats. Reviewed
Han W, Utoyoma M, Akieda-Asai S, Hidaka A, Yamada C, Hasegawa K, Nunoi H, Date Y
Exp Physiol 103 ( 10 ) 1347 - 1356 2018.10
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1113/EP087072
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Akieda-Asai S., Ida T., Miyazato M., Kangawa K., Date Y.
Peptides 99 14 - 19 2018.1
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Peptides
Recently we found that guanylin (Gn) and its receptor, guanylyl cyclase C (GC-C), are uniquely expressed in the mesenteric macrophages of some diet-resistant rats and that double-transgenic (dTg) rats overexpressing Gn and GC-C in macrophages demonstrate reduced fatty acid synthase and fat accumulation in fat tissue even when fed a high-fat diet (HFD). Lipid accumulation and fatty acid synthase mRNA levels in cocultured dTg rat adipocytes and macrophages were reduced compared with those in adipocytes cultured with WT rat macrophages. Here, we investigated whether Interleukin-15 (IL-15) derived from Gn–GC-C-expressing macrophages regulates lipid accumulation in adipocytes. IL-15 inhibited fatty acid synthase and lipid accumulation via STAT5 in cultured adipocytes. IL-15 mRNA and protein levels in the mesenteric fat of HFD-fed dTg rats were significantly higher than those of HFD-fed WT rats. Phosphorylated STAT5 levels in the mesenteric fat of HFD-fed dTg rats were increased compared with those of HFD-fed WT rats. In addition, the mRNA level of fatty acid synthase in the mesenteric fat was lower in HFD-fed dTg rats than in HFD-fed WT rats. These results support the hypothesis that IL-15 secreted from Gn–GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance.
MISC 【 display / non-display 】
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糖尿病と食物性状の関わり Invited
秋枝さやか
DITN 2017.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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Cross-talk of periphery with central in feeding behavior.
Sayaka Akieda, Yukari Date.
Kagaku To Seibutsu 47 ( 11 ) 750 - 755 2009.11
Language：Japanese Publishing type：Research paper, summary (national, other academic conference) Publisher：Japan Scientific Societies Press
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Development of imaging mass spectrometry
Sayaka Asai, Mitsutoshi Setou.
Gendaikagaku 434 51 - 55 2007.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：Tokyo Kagaku Dojin
Presentations 【 display / non-display 】
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軟食摂取による肥満のない2型糖尿病の病態メカニズムの解明 Invited
秋枝さやか, 馬浩, 山口史剛, 伊達紫
第96回日本内分泌学会
Event date： 2023.6.3
Presentation type：Symposium, workshop panel (nominated)
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グアニリン・グアニル酸シクラーゼC発現マクロファージ由来のIL-15は脂肪の蓄積を抑制する Invited
秋枝さやか, 山口史剛, 伊達紫
第45回日本分子生物学会
Event date： 2022.12.2
Presentation type：Symposium, workshop panel (public)
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Mechanism of muscle atrophy in a normal-weight rat model of type 2 diabetes established by using a soft-pellet diet Invited International conference
Sayaka Akieda-Asai
Cognition Conference 2024.11.18
Event date： 2024.11.18 - 2024.11.20
Language：English Presentation type：Oral presentation (invited, special)
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軟食摂取による肥満のない2型糖尿病ラットモデルの病態メカニズムの解明
秋枝さやか, 山口史剛, 伊達紫
第71回日本実験動物学会総会
Event date： 2024.5.29 - 2024.5.31
Presentation type：Oral presentation (general)
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軟食摂取による2型糖尿病の病態解析
秋枝さやか, 山口史剛, 伊達紫
第46回日本分子生物学会年会
Event date： 2023.12.8
Presentation type：Poster presentation
Awards 【 display / non-display 】
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2016年度 ひと・健康・未来財団 助成研究発表会 優秀賞 食品分野
2016.11 公益財団法人ひと・健康・未来財団
秋枝さやか
Award type：Award from publisher, newspaper, foundation, etc. Country：Japan
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第155回日本獣医学会大会長賞受賞
2013.3 日本獣医学会
秋枝さやか
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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宮崎大学女性研究者奨励賞(研究部門）
2013.3 宮崎大学
秋枝さやか
Country：Japan
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コスモ・バイオ学術論文賞
2012.12 コスモ・バイオ株式会社
J Lipid Res, 2013 論文
Country：Japan
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第17回日本下垂体研究会, 優秀ポスター賞
2002.8 日本下垂体研究会
浅井さやか
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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胎児期の低栄養環境による行動異常の発症とその早期診断に有効なマーカーに関する研究
Grant number：24K14793 2024.04 - 2028.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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成長期の口腔育成から子どもロコモと高齢期オーラルフレイルを予防する新戦略
Grant number：23K02258 2023.04
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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肥満のない2型糖尿病の発症と進展機序の解明
Grant number：22K11806 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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軟らかい食べ物が招く生活習慣病の発症機序に関する研究
Grant number：22H00952 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
伊達 紫、
Authorship：Coinvestigator(s)
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日本人型糖尿病モデルラットの軟食飼育が糖尿病と咀嚼器官の発達と老化に及ぼす影響
Grant number：17K01905 2017.04 - 2020.03
科学研究費補助金 基盤研究(C)
Available Technology 【 display / non-display 】
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軟らかい食餌に起因する２型糖尿病の発症機構の解明
肥満を回避する生体メカニズムの解明
食欲•摂食調節機構の解明Home Page： フロンティア科学総合研究センター 生理活性物質機能解析分野
Related fields where technical consultation is available：食品成分、化合物、生理活性物質などの機能性評価や生体への影響
Message：生理活性物質を中心に内分泌、代謝、神経、行動など生体制御に関連する臓器間関連を解析しています。