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Affiliation |
Faculty of Medicine School of Medicine Department of Medical Sciences, Cardiovascular Physiology |
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Assistant Professor |
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Related SDGs |
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MADHYASTHA HARISHKUMAR
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Degree 【 display / non-display 】
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Ph. D ( 2006.10 Miyazaki Medical College )
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博士（植物学） ( 1996.12 サルダル パテル大学 )
Papers 【 display / non-display 】
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In vitro apoptotic potential and ex vivo permeation analysis of ulipristal acetate loaded niosomes for management of uterine fibroids. Reviewed
Aparajay P, Madhyastha H, Bhowmik S, Dev A
Journal of microencapsulation 1 - 13 2025.5
Language：English Publishing type：Research paper (scientific journal)
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Functionalized Niosomes for Co-Delivery of Curcumin and Imatinib Mesylate to Treat Breast Cancer: In Vitro and In Vivo Investigations. Reviewed
Aparajay P, Madhyastha H, Altamimi MA, Dev A, Hussain A, Bhowmik S
AAPS PharmSciTech 26 ( 5 ) 119 2025.4
Language：English Publishing type：Research paper (scientific journal)
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Osteo-modulatory potential of biologically synthesized cis-resveratrol passivated gold nanoparticles. Reviewed
Gupta A, Madhyastha H, Kumar A, Singh S
International journal of pharmaceutics 664 124637 2024.10
Language：English Publishing type：Research paper (scientific journal)
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Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin sulfate-based in-situ forming wound dressing Reviewed International coauthorship
Sharma S., Madhyastha H., Kirwale S.S., Sakai K., Katakia Y.T., Majumder S., Roy A.
Carbohydrate Polymers 298 2022.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Carbohydrate Polymers
None of the currently available wound dressings exhibit combined antibacterial and anti-inflammatory activity. Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells. The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production. Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production. Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis. In summary, this study exhibited that CH-CS PEC has substantial antibacterial and immunomodulatory properties.
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Mathiyazhagan J., Madhyastha H., Nalini E., Gothandam K.M.
Current Trends in Biotechnology and Pharmacy 16 56 - 63 2022.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Current Trends in Biotechnology and Pharmacy
Ocimum sanctum and Piper nigrum are medicinal plants traditionally used in Ayurveda and other ancient therapeutic systems. Till today people use these plants In one of the different aspects of their everyday life. This study revealed the combined effect of O. sanctum and P. nigrum (1:1) against diabetic-related enzymes in a cell-free system and breast cancer cell line (MCF-7). The HPLC analysis revealed that Eugenol and Piperine are the major phytocompounds in O. sanctum and P. nigrum, respectively. Digestive enzymes like a- amylase and a- glucos¡dase assays were carried out to find their antidiabetic effect. To determine the Interaction between Piperine and eugenol with enzymes involved in diabetes, the in silico molecular docking analysis was performed. The plant extracts alone and in combination, were checked for their cytotoxicity and reactive oxygen species levels in MCF-7 cells.
Books 【 display / non-display 】
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Nanotoxicology: Toxicity evaluation, risk assessment and management
Umapathi A, Kaphle A, Navya PN, Firdose N, Monnappa S, Jain D, Srinivas SP, Madhyastha HK, Madhyastha R, Daima HK（ Role： Joint author）
CRC Press, Taylor and Francis group 2017.5
Language：English Book type：Scholarly book
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Polymeric nanocarriers for vaccine delivery.
Shakya A K and Madhyastha Harishkumar（ Role： Joint author）
In Integrating biologically inspired nanotechnology into medical practice 2016.8
Language：English Book type：Scholarly book
MISC 【 display / non-display 】
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Biogenesis and functional implications of extracellular vesicles in cancer metastasis.
Sekar S, Srikanth S, Mukherjee AG, Gopalakrishnan AV, Wanjari UR, Vellingiri B, Renu K, Madhyastha H
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 27 ( 7 ) 2913 - 2935 2025.7
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Is periodontitis triggering an inflammatory response in the liver, and does this reaction entail oxidative stress?
Renu K, Gopalakrishnan AV, Madhyastha H
Odontology 113 ( 3 ) 889 - 902 2025.7
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Unraveling the mystery of citrate transporters in Alzheimer's disease: An updated review.
Mukherjee AG, Mishra S, Gopalakrishnan AV, Kannampuzha S, Murali R, Wanjari UR, B S, Vellingiri B, Madhyastha H, Kanagavel D, Vijayan M
Ageing research reviews 107 102726 2025.5
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Hair and Nail-On-Chip for Bioinspired Microfluidic Device Fabrication and Biomarker Detection.
Ray R, Rakesh A, Singh S, Madhyastha H, Mani NK
Critical reviews in analytical chemistry 55 ( 3 ) 434 - 460 2025
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Understanding gut microbiome-based machine learning platforms: A review on therapeutic approaches using deep learning.
Malakar S, Sutaoney P, Madhyastha H, Shah K, Chauhan NS, Banerjee P
Chemical biology & drug design 103 ( 3 ) e14505 2024.3
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
DOI： 10.1111/cbdd.14505
Presentations 【 display / non-display 】
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Silver primed nutraceutical hybrids: cellular and hematological evaluation Invited International conference
Madhyastha H, Madhyastha r., Nakajima Y., Maruyama M.
BioTERM
Event date： 2019.11.30 - 2019.12.3
Language：English Presentation type：Oral presentation (invited, special)
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Silver primed nutraceutical hybrids: cellular and hematological evaluation Invited International conference
Madhyastha H, Madhyastha r., Nakajima Y., Maruyama M.
BioTERM
Event date： 2019.11.30 - 2019.12.3
Language：English Presentation type：Oral presentation (invited, special)
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Phycocyanin hybridized silver conjugates in wound healing-cell toxicity evaluation Invited International conference
Madhyastha H, Madhyastha R., Nakajima Y., Maruyama M.
New Horizon in Biotechnology
Event date： 2019.11.20 - 2019.11.29
Language：English Presentation type：Oral presentation (invited, special)
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Phycocyanin hybridized silver conjugates in wound healing-cell toxicity evaluation Invited International conference
Madhyastha H, Madhyastha R., Nakajima Y., Maruyama M.
New Horizon in Biotechnology
Event date： 2019.11.20 - 2019.11.29
Language：English Presentation type：Oral presentation (invited, special)
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Potential of intracellular protein and its hydrolysates from epiphytic bacteria associated with brown algae, Sargassum sp. as anticancer agents.
Nur Asmi, Ahyar Ahmad, Hasnah Natsir, Muh. Nasrum Massi, Harishkumar Madhyastha, Radha Madhyastha, Yuichi Nakajima, Masugi Maruyama.
西日本生理学会 (宮崎大学)
Event date： 2019.11.1 - 2019.11.2
Language：English Presentation type：Oral presentation (general)
Venue：宮崎大学
Grant-in-Aid for Scientific Research 【 display / non-display 】
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FMR治療における病理、遺伝子発現機構からの検証に基づいた左房機能評価の意義の確立
Grant number：23K08239 2023.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Coinvestigator(s)