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医学部 医学科 機能制御学講座循環動態生理学分野 |
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助教 |
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マドゥエスタ ハリーシャクマール (マドウエスタ ハリーシヤクマール)
MADHYASTHA HARISHKUMAR
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論文 【 表示 ／ 非表示 】
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In vitro apoptotic potential and ex vivo permeation analysis of ulipristal acetate loaded niosomes for management of uterine fibroids. 査読あり
Aparajay P, Madhyastha H, Bhowmik S, Dev A
Journal of microencapsulation 1 - 13 2025年5月
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Functionalized Niosomes for Co-Delivery of Curcumin and Imatinib Mesylate to Treat Breast Cancer: In Vitro and In Vivo Investigations. 査読あり
Aparajay P, Madhyastha H, Altamimi MA, Dev A, Hussain A, Bhowmik S
AAPS PharmSciTech 26 ( 5 ) 119 2025年4月
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Osteo-modulatory potential of biologically synthesized cis-resveratrol passivated gold nanoparticles. 査読あり
Gupta A, Madhyastha H, Kumar A, Singh S
International journal of pharmaceutics 664 124637 2024年10月
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Sharma S., Madhyastha H., Kirwale S.S., Sakai K., Katakia Y.T., Majumder S., Roy A.
Carbohydrate Polymers 298 2022年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Carbohydrate Polymers
None of the currently available wound dressings exhibit combined antibacterial and anti-inflammatory activity. Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells. The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production. Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production. Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis. In summary, this study exhibited that CH-CS PEC has substantial antibacterial and immunomodulatory properties.
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Mathiyazhagan J., Madhyastha H., Nalini E., Gothandam K.M.
Current Trends in Biotechnology and Pharmacy 16 56 - 63 2022年6月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Current Trends in Biotechnology and Pharmacy
Ocimum sanctum and Piper nigrum are medicinal plants traditionally used in Ayurveda and other ancient therapeutic systems. Till today people use these plants In one of the different aspects of their everyday life. This study revealed the combined effect of O. sanctum and P. nigrum (1:1) against diabetic-related enzymes in a cell-free system and breast cancer cell line (MCF-7). The HPLC analysis revealed that Eugenol and Piperine are the major phytocompounds in O. sanctum and P. nigrum, respectively. Digestive enzymes like a- amylase and a- glucos¡dase assays were carried out to find their antidiabetic effect. To determine the Interaction between Piperine and eugenol with enzymes involved in diabetes, the in silico molecular docking analysis was performed. The plant extracts alone and in combination, were checked for their cytotoxicity and reactive oxygen species levels in MCF-7 cells.
書籍等出版物 【 表示 ／ 非表示 】
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Nanotoxicology: Toxicity evaluation, risk assessment and management
Umapathi A, Kaphle A, Navya PN, Firdose N, Monnappa S, Jain D, Srinivas SP, Madhyastha HK, Madhyastha R, Daima HK（ 担当： 共著）
CRC Press, Taylor and Francis group 2017年5月
記述言語：英語 著書種別：学術書
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Polymeric nanocarriers for vaccine delivery.
Shakya A K and Madhyastha Harishkumar（ 担当： 共著）
In Integrating biologically inspired nanotechnology into medical practice 2016年8月
記述言語：英語 著書種別：学術書
MISC 【 表示 ／ 非表示 】
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Biogenesis and functional implications of extracellular vesicles in cancer metastasis.
Sekar S, Srikanth S, Mukherjee AG, Gopalakrishnan AV, Wanjari UR, Vellingiri B, Renu K, Madhyastha H
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 27 ( 7 ) 2913 - 2935 2025年7月
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Is periodontitis triggering an inflammatory response in the liver, and does this reaction entail oxidative stress?
Renu K, Gopalakrishnan AV, Madhyastha H
Odontology 113 ( 3 ) 889 - 902 2025年7月
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Unraveling the mystery of citrate transporters in Alzheimer's disease: An updated review.
Mukherjee AG, Mishra S, Gopalakrishnan AV, Kannampuzha S, Murali R, Wanjari UR, B S, Vellingiri B, Madhyastha H, Kanagavel D, Vijayan M
Ageing research reviews 107 102726 2025年5月
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Hair and Nail-On-Chip for Bioinspired Microfluidic Device Fabrication and Biomarker Detection.
Ray R, Rakesh A, Singh S, Madhyastha H, Mani NK
Critical reviews in analytical chemistry 55 ( 3 ) 434 - 460 2025年
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Understanding gut microbiome-based machine learning platforms: A review on therapeutic approaches using deep learning.
Malakar S, Sutaoney P, Madhyastha H, Shah K, Chauhan NS, Banerjee P
Chemical biology & drug design 103 ( 3 ) e14505 2024年3月
講演・口頭発表等 【 表示 ／ 非表示 】
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Silver primed nutraceutical hybrids: cellular and hematological evaluation 招待あり 国際会議
Madhyastha H, Madhyastha r., Nakajima Y., Maruyama M.
BioTERM
開催年月日： 2019年11月30日 - 2019年12月3日
記述言語：英語 会議種別：口頭発表（招待・特別）
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Silver primed nutraceutical hybrids: cellular and hematological evaluation 招待あり 国際会議
Madhyastha H, Madhyastha r., Nakajima Y., Maruyama M.
BioTERM
開催年月日： 2019年11月30日 - 2019年12月3日
記述言語：英語 会議種別：口頭発表（招待・特別）
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Phycocyanin hybridized silver conjugates in wound healing-cell toxicity evaluation 招待あり 国際会議
Madhyastha H, Madhyastha R., Nakajima Y., Maruyama M.
New Horizon in Biotechnology
開催年月日： 2019年11月20日 - 2019年11月29日
記述言語：英語 会議種別：口頭発表（招待・特別）
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Phycocyanin hybridized silver conjugates in wound healing-cell toxicity evaluation 招待あり 国際会議
Madhyastha H, Madhyastha R., Nakajima Y., Maruyama M.
New Horizon in Biotechnology
開催年月日： 2019年11月20日 - 2019年11月29日
記述言語：英語 会議種別：口頭発表（招待・特別）
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Potential of intracellular protein and its hydrolysates from epiphytic bacteria associated with brown algae, Sargassum sp. as anticancer agents.
Nur Asmi, Ahyar Ahmad, Hasnah Natsir, Muh. Nasrum Massi, Harishkumar Madhyastha, Radha Madhyastha, Yuichi Nakajima, Masugi Maruyama.
西日本生理学会 (宮崎大学)
開催年月日： 2019年11月1日 - 2019年11月2日
記述言語：英語 会議種別：口頭発表（一般）
開催地：宮崎大学
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
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FMR治療における病理、遺伝子発現機構からの検証に基づいた左房機能評価の意義の確立
研究課題/領域番号：23K08239 2023年04月 - 2027年03月
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
担当区分：研究分担者