IDA Takanori

写真a

Affiliation

Frontier Science Research Center Life science field of inquiry physiology activator search condition analysis field

Title

Associate Professor

External Link

Degree 【 display / non-display

  • 博士(獣医学) ( 2004.3   山口大学 )

Research Areas 【 display / non-display

  • Life Science / Veterinary medical science

 

Papers 【 display / non-display

  • Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats Reviewed

    Jiang D., Matsuzaki M., Ida T., Kitamura K., Tsuruda T., Kaikita K., Kato J.

    Peptides   166   171035   2023.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Peptides  

    Excessive activation of the sympathetic nervous system is involved in cardiovascular damage including cardiac hypertrophy. Natriuretic peptides are assumed to exert protective actions for the heart, alleviating hypertrophy and/or fibrosis of the myocardium. In contrast to this assumption, we show in the present study that both atrial and C-type natriuretic peptides (ANP and CNP) potentiate cardiac hypertrophic response to noradrenaline (NA) in rats. Nine-week-old male Wistar rats were continuously infused with subcutaneous 30 micro-g/h NA without or with persistent intravenous administration of either 1.0 micro-g/h ANP or CNP for 14 days. Blood pressure (BP) was recorded under an unrestrained condition by a radiotelemetry system. Cardiac hypertrophic response to NA was evaluated by heart weight/body weight (HW/BW) ratio and microscopic measurement of myocyte size of the left ventricle. Mean BP levels at the light and dark cycles rose by about 20 mmHg following NA infusion for 14 days, with slight increases in HW/BW ratio and ventricular myocyte size. Infusions of ANP and CNP had no significant effects on mean BP in NA-infused rats, while two natriuretic peptides potentiated cardiac hypertrophic response to NA. Cardiac hypertrophy induced by co-administration of NA and ANP was attenuated by treatment with prazosin or atenolol. In summary, both ANP and CNP potentiated cardiac hypertrophic effect of continuously infused NA in rats, suggesting a possible pro-hypertrophic action of natriuretic peptides on the heart.

    DOI: 10.1016/j.peptides.2023.171035

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  • Root-knot nematode modulates plant CLE3-CLV1 signaling as a long-distance signal for successful infection Reviewed

    Nakagami S., Notaguchi M., Kondo T., Okamoto S., Ida T., Sato Y., Higashiyama T., Tsai A.Y.L., Ishida T., Sawa S.

    Science advances   9 ( 22 )   eadf4803   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Science advances  

    Plants use many long-distance and systemic signals to modulate growth and development, as well as respond to biotic and abiotic stresses. Parasitic nematodes infect host plant roots and cause severe damage to crop plants. However, the molecular mechanisms that regulate parasitic nematode infections are still unknown. Here, we show that plant parasitic root-knot nematodes (RKNs), Meloidogyne incognita, modulate the host CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION (CLE)-CLV1 signaling module to promote the infection progression. Plants deficient in the CLE signaling pathway show enhanced RKN resistance, whereas CLE overexpression leads to increased susceptibility toward RKN. Grafting analysis shows that CLV1 expression in the shoot alone is sufficient to positively regulate RKN infection. Together with results from the split-root culture system, infection assays, and CLE3-CLV1 binding assays, we conclude that mobile root-derived CLE signals are perceived by CLV1 in the shoot, which subsequently produce systemic signals to promote gall formation and RKN reproduction.

    DOI: 10.1126/sciadv.adf4803

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  • Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian Species. Reviewed

    Yazawa T, Islam MS, Imamichi Y, Watanabe H, Yaegashi K, Ida T, Sato T, Kitano T, Matsuzaki S, Umezawa A, Muranishi Y

    Animals : an open access journal from MDPI   13 ( 4 )   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Animals  

    During mammalian gestation, large amounts of progesterone are produced by the placenta and circulate for the maintenance of pregnancy. In contrast, primary plasma estrogens are different between species. To account for this difference, we compared the expression of ovarian and placental steroidogenic genes in various mammalian species (mouse, guinea pig, porcine, ovine, bovine, and human). Consistent with the ability to synthesize progesterone, CYP11A1/Cyp11a1, and bi-functional HSD3B/Hsd3b genes were expressed in all species. CYP17A1/Cyp17a1 was expressed in the placenta of all species, excluding humans. CYP19A/Cyp19a1 was expressed in all placental estrogen-producing species, whereas estradiol-producing HSD17B1 was only strongly expressed in the human placenta. The promoter region of HSD17B1 in various species possesses a well-conserved SP1 site that was activated in human placental cell line JEG-3 cells. However, DNA methylation analyses in the ovine placenta showed that the SP1-site in the promoter region of HSD17B1 was completely methylated. These results indicate that epigenetic regulation of HSD17B1 expression is important for species-specific placental sex steroid production. Because human HSD17B1 showed strong activity for the conversion of androstenedione into testosterone, similar to HSD17B1/Hsd17b1 in other species, we also discuss the biological significance of human placental HSD17B1 based on the symptoms of aromatase-deficient patients.

    DOI: 10.3390/ani13040622

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  • A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon-derived peptide levels. Reviewed

    Kobayashi M, Maruyama N, Yamamoto Y, Togawa T, Ida T, Yoshida M, Miyazato M, Kitada M, Hayashi Y, Kashiwagi A, Kitamura T

    Journal of diabetes investigation   14 ( 5 )   648 - 658   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Diabetes Investigation  

    Aims/Introduction: Glucagon, a peptide hormone produced from proglucagon, is involved in the pathophysiology of diabetes. Plasma glucagon levels are currently measured by sandwich enzyme-linked immunosorbent assay (ELISA), but the currently used sandwich ELISA cross-reacts with proglucagon-derived peptides, thereby providing incorrect results in subjects with elevated plasma proglucagon-derived peptide levels. We aimed to develop a more broadly reliable ELISA for measuring plasma glucagon levels. Materials and Methods: A new sandwich ELISA was developed using newly generated monoclonal antibodies against glucagon. After its validation, plasma glucagon levels were measured with the new ELISA and the currently used ELISA in subjects who underwent laparoscopic sleeve gastrectomy (LSG) and in outpatients with suspected glucose intolerance. The ELISA results were compared with those from liquid chromatography-high resolution mass (LC-HRMS) analysis, which we previously established as the most accurate measuring system. Results: The new ELISA has high specificity (<1% cross-reactivities) and high sensitivity (a lower range of 0.31 pmol/L). Plasma glucagon values in the subjects who underwent laparoscopic sleeve gastrectomy and some outpatients with suspected glucose intolerance differed between the new ELISA and the currently used ELISA. These subjects also showed markedly high plasma glicentin levels. Despite the elevated plasma glicentin levels, the new ELISA showed better positive correlation with LC-HRMS than did the currently used ELISA. Conclusions: The new ELISA enables more accurate measurement of plasma glucagon than the currently used ELISA, even in subjects with elevated proglucagon-derived peptide levels. It should be clinically useful in elucidating the pathophysiology of individual diabetic patients.

    DOI: 10.1111/jdi.13986

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  • Insights into the Regulation of Offspring Growth by Maternally Derived Ghrelin Reviewed

    Sato T, Ida T, Shimura Y, IMatsui K, Oishi K, Kojima M

    Frontiers in Endocrinology   13   852636   2022

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Frontiers in Endocrinology  

    The regulation of fetal development by bioactive substances such as hormones and neuropeptides derived from the gestational mother is considered to be essential for the development of the fetus. On the other hand, it has been suggested that changes in the physiological state of the pregnant mother due to various factors may alter the secretion of these bioactive substances and induce metabolic changes in the offspring, such as obesity, overeating, and inflammation, thereby affecting postnatal growth and health. However, our knowledge of how gestational maternal bioactive substances modulate offspring physiology remains fragmented and lacks a systematic understanding. In this mini-review, we focus on ghrelin, which regulates growth and energy metabolism, to advance our understanding of the mechanisms by which maternally derived ghrelin regulates the growth and health of the offspring. Understanding the regulation of offspring growth by maternally-derived ghrelin is expected to clarify the fetal onset of metabolic abnormalities and lead to a better understanding of lifelong health in the next generation of offspring.

    DOI: 10.3389/fendo.2022.852636

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  • 消化管関連ペプチドが拓く恒常性フロンティア Invited

    佐藤貴弘、井田隆徳、関口俊男、中町智哉、児島将康

    実験医学   37 ( 3 )   1 - 8   2019

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • Role of biological rhythms in the performance of physical activity Invited Reviewed

    Sato T, Ida T, Kojima M

    The Journal of Physical Fitness and Sports Medicine   6 ( 3 )   125 - 134   2017.3

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  • モデル生物を利用した新規摂食調節ペプチドの探索

    井田隆徳

    生物科学   2016.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:農山漁村文化協会  

  • Correction: The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster [PLoS Genet, 11(9), (2015)]

    Sano H., Nakamura A., Texada M., Truman J., Ishimoto H., Kamikouchi A., Nibu Y., Kume K., Ida T., Kojima M.

    PLoS Genetics   11 ( 9 )   2015.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:PLoS Genetics  

    DOI: 10.1371/journal.pgen.1005481

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  • 摂食調節ペプチドと飢餓応答

    佐藤貴弘、井田隆徳、児島将康

    The lipid   26 ( 1 )   35 - 39   2015.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:メディカルレビュー社  

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Presentations 【 display / non-display

  • 新規生理活性ペプチドの探索と応用 Invited

    井田隆徳

    第70回日本心臓病学会学術集会  2022.9.23 

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    Event date: 2022.9.23

    Language:Japanese   Presentation type:Oral presentation (general)  

  • ブタ副腎における11-ケトテストステロン産生経路の解明

    矢澤隆志、佐藤貴弘、井田隆徳

    第27回日本生殖内分泌学会  2022.12.17 

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    Event date: 2022.12.17

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 新規生理活性ペプチドの探索

    井田隆徳

    第12回ペプチド・ホルモン研究会  2022.11.12 

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    Event date: 2022.11.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  • ヒトとウナギの血中アンドロゲンと産生経路の比較

    井田隆徳、佐藤貴弘、矢澤隆志

    日本動物学会第93回大会  2022.9.8 

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    Event date: 2022.9.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  • モデル生物を用いた新規生理活性ペプチドの探索と応用

    井田隆徳、佐藤貴弘、矢澤隆志

    第165回日本獣医学会学術集会  2022.9.6 

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    Event date: 2022.9.6 - 2022.9.8

    Language:Japanese   Presentation type:Oral presentation (general)  

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Awards 【 display / non-display

  • 日本獣医学会生理学・生化学分科会奨励賞

    2010.9   日本獣医学会  

    井田隆徳

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 11th International Conference on Human-Animal Interactions.Best Poster Award

    2007.10   IAHAIO  

    Yoshidomi Y, Ikeda Y, Satoh H, Sekino R, Ida T, Hisatomi I, Nakatsuka K, Misawa N

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • 摂食・エネルギー代謝を制御する新規生理活性ペプチドの発見と応用

    Grant number:21K05958  2021.04 - 2024.03

    独立行政法人日本学術振興会  科学研究費補助金  基盤研究C

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    Authorship:Principal investigator 

  • 生体必須の金属補因子「鉄硫黄クラスター」の生合成機序と無細胞構築系の確立

    Grant number:20H03196  2020.04 - 2024.03

    独立行政法人日本学術振興会  科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

  • 難治性の神経因性疼痛を抑制する脳由来新規生理活性物質の構造決定と生理作用の解析

    Grant number:20K07768  2020.04 - 2023.03

    独立行政法人日本学術振興会  科学研究費補助金  基盤研究(C)

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  • 新規NPY様RYamideペプチドの発見と食欲調節機構の解析

    2017.04 - 2020.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • 昆虫における食欲促進/減退を引き起こす生理活性ペプチドの発見

    2014.04 - 2017.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    昆虫における食欲促進/減退を引き起こす生理活性ペプチドの発見し解析する

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Other research activities 【 display / non-display

  • 食鳥処理施設での脳のサンプリング

    2019.07

  • 食鳥処理施設での肝臓のサンプリング

    2018.06

  • 食肉処理施設における膵臓のサンプリング

    2017.07

  • 食鳥処理施設での脳のサンプリング

    2017.05

  • 食鳥処理場における新規生理活性ペプチド、ステロイドホルモンの探索

    2017.03

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    食鳥処理場においてウシ、ブタ、ニワトリから様々な臓器をサンプリングし、新規生理活性ペプチド、ステロイドホルモンの探索を行う。

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