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Faculty of Agriculture Region of Veterinary Science |
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Professor |
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Related SDGs |
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IDA Takanori
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Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
Papers 【 display / non-display 】
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Metabolic Regulation of Body Size Determination by Genetic and Environmental Factors Reviewed
NEMOTO TAKAHIRO, SHIIMURA YUKI, IDA TAKANORI, SATO TAKAHIRO
The Kurume Medical Journal advpub ( 0 ) 2026.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Kurume University School of Medicine
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Okinishi R., Watanabe T., Ida T., Wong M.K.S., Izumi T., Tsuneoka Y., Tsukada T.
General and Comparative Endocrinology 381 114948 2026.4
Language：English Publishing type：Research paper (scientific journal) Publisher：General and Comparative Endocrinology
Natriuretic peptides (NPs) play critical roles in cardiovascular and osmoregulatory homeostasis via guanylyl cyclase-coupled natriuretic peptide receptors (NPRs). Although teleost fishes possess a diverse NP repertoire, their receptor systems remain incompletely understood. In the present study, we identified and characterized a novel npr1 paralog ( npr1a ) in the Japanese eel ( Anguilla japonica ), a representative of early-diverging lineages. Phylogenetic and synteny analyses revealed that eel npr1a and the previously reported npr1b (also known as npra) are teleost-specific paralogs generated by the third round of whole-genome duplication (3R). Functional analysis using COS-7 cells demonstrated distinct ligand responsiveness: Npr1a exhibited preferential responsiveness to VNP with lower signaling efficacy than Npr1b, whereas Npr1b responded broadly to cardiac NPs (eel ANP-NH<inf>2</inf> > VNP > BNP). In situ hybridization chain reaction revealed marked spatial divergence of these receptors in the eel brain: npr1a was predominantly localized in the parvocellular preoptic nucleus (Pp) and anterior tuberal nucleus (NAT), whereas npr1b was specifically expressed in the area postrema (AP). These regions are located at or near blood–brain barrier-deficient areas. Notably, RT-qPCR data showed that npr1b expression was significantly upregulated in seawater-acclimated eels, while npr1a levels remained stable, indicating distinct transcriptional regulation. Collectively, our findings demonstrate 3R-driven subfunctionalization of Npr1 in the Japanese eel and suggest that the retention of vnp in early-diverging lineages may have facilitated lineage-specific functional diversification of NP receptors during teleost evolution.
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Microinjection of Synthetic Peptides into Caenorhabditis elegans Reviewed
Ohno H, Ida T, Iino Y.
Bio Protoc. 2026
Authorship：Corresponding author Publishing type：Research paper (scientific journal)
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Metabolic Regulation of Body Size Determination by Genetic and Environmental Factors Reviewed
Nemoto T, Shiimura Y, Ida T, Sato T
Kurume Med J 2026
Publishing type：Research paper (scientific journal)
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Discovery of Feeding Regulatory Peptides and The Importance of Peptide Discovery Research
IDA TAKANORI, MATSUI KAZUMA, NAGATA SAYAKA, NAKAMACHI TOMOYA, SHIIMURA YUKI, SATO TAKAHIRO, KOJIMA MASAYASU
The Kurume Medical Journal 71 ( 3 ) 89 - 109 2024.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Kurume University School of Medicine
<b>Summary:</b> Bioactive peptides consist of multiple linked amino acids that are secreted from cells and act on specific receptors in order to transmit information from one cell to another. Through signal transduction, bioactive peptides regulate various physiological functions in the body, and the discovery of new bioactive peptides is therefore likely to lead to the development of various diagnostic and therapeutic agents. In this article, we have focused on the bioactive peptides that are known as feeding regulatory peptides. They are among the bioactive peptides discovered as ligands for G protein-coupled receptors (GPCRs), and we have reviewed their diverse functions. In addition, the status of structural analysis of GPCRs, which is necessary in the drug discovery process, and research on orphan GPCRs, for which new ligands are expected to be discovered in the future, is introduced to systematize modern peptide research and discuss future developments in bioactive peptide research.
MISC 【 display / non-display 】
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Discovery of feeding regulatory peptides and the importance of peptide discovery research Reviewed
Ida T, Matsui K, Nagata S, Nakamachi T, Shiimura Y, Sato T, Kojima M.
The Kurume Medical Journal 2025.3
Authorship：Lead author, Corresponding author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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消化管関連ペプチドが拓く恒常性フロンティア Invited
佐藤貴弘、井田隆徳、関口俊男、中町智哉、児島将康
実験医学 37 ( 3 ) 1 - 8 2019
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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Role of biological rhythms in the performance of physical activity Invited Reviewed
Sato T, Ida T, Kojima M
The Journal of Physical Fitness and Sports Medicine 6 ( 3 ) 125 - 134 2017.3
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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モデル生物を利用した新規摂食調節ペプチドの探索
井田隆徳
生物科学 2016.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：農山漁村文化協会
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Sano H., Nakamura A., Texada M., Truman J., Ishimoto H., Kamikouchi A., Nibu Y., Kume K., Ida T., Kojima M.
PLoS Genetics 11 ( 9 ) 2015.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：PLoS Genetics
Presentations 【 display / non-display 】
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New frontiers in comparative endocrinology through research into novel bioactive peptides in model organisms Invited International conference
Takanori Ida, Takahiro Sato, Masayasu Kojima
19th International congress of comparative endocrinology
Event date： 2025.7.8 - 2025.7.12
Language：English Presentation type：Oral presentation (general)
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動物介在活動から考えるOne Health Invited
井田隆徳
第１６６回日本獣医学会学術集会
Event date： 2023.9.5
Presentation type：Oral presentation (general)
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新規生理活性ペプチドの探索と応用 Invited
井田隆徳
第70回日本心臓病学会学術集会 2022.9.23
Event date： 2022.9.23
Language：Japanese Presentation type：Oral presentation (general)
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Orphan GPCRに対する内因性リガンドの探索と応用
井田隆徳、佐藤貴弘、長谷川和哉、矢澤隆志
第76回西日本生理学会
Event date： 2025.10.31
Presentation type：Oral presentation (general)
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オーファンGPCRに対する内因性リガンドの探索と応用
井田隆徳、佐藤貴弘、長谷川和哉、矢澤隆志
第51回日本神経内分泌学会学術集会
Event date： 2025.10.25
Presentation type：Poster presentation
Awards 【 display / non-display 】
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日本獣医学会生理学・生化学分科会奨励賞
2010.9 日本獣医学会
井田隆徳
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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11th International Conference on Human-Animal Interactions.Best Poster Award
2007.10 IAHAIO
Yoshidomi Y, Ikeda Y, Satoh H, Sekino R, Ida T, Hisatomi I, Nakatsuka K, Misawa N
Award type：Award from international society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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植物の耐寒性を増強する低温センシング機構の解明
Grant number：24K01683 2024.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship：Coinvestigator(s)
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運動によって生体内で産生される匂い物質の器官嗅覚受容体を介した生理作用の解明
Grant number：24K22277 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 挑戦的研究（萌芽）
Authorship：Coinvestigator(s)
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急速減量による急性腎障害発症メカニズムの解明とその抑制法の基盤研究
Grant number：23K27975 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship：Coinvestigator(s)
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摂食・エネルギー代謝を制御する新規生理活性ペプチドの発見と応用
Grant number：21K05958 2021.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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生体必須の金属補因子「鉄硫黄クラスター」の生合成機序と無細胞構築系の確立
Grant number：20H03196 2020.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
Authorship：Coinvestigator(s)
Other research activities 【 display / non-display 】
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食鳥処理施設での下垂体のサンプリング
2025.12
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テニュアトラック トロイカサポーター
2025.01
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食鳥処理施設での骨髄のサンプリング
2023.11
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食鳥処理施設での脳のサンプリング
2019.07
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食鳥処理施設での肝臓のサンプリング
2018.06
Available Technology 【 display / non-display 】
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新規生理活性ペプチドの探索
新規生理活性ペプチドの機能解析
病態モデル生物の作製Home Page： 獣医生理学教室
Related fields where technical consultation is available：ペプチド抽出
受容体発現細胞を用いたセカンドメッセンジャーアッセイMessage：宮崎大学の伝統あるペプチド研究を引き継ぎ、ペプチド研究におけるプラットフォームを目指しています。