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Affiliation |
Frontier Science Research Center Life science field of inquiry physiology activator search condition analysis field |
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Associate Professor |
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External Link |
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IDA Takanori
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Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
Papers 【 display / non-display 】
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Jiang D, Matsuzaki M, Ida T, Kitamura K, Kato J
Hypertension research : official journal of the Japanese Society of Hypertension 47 ( 4 ) 1017 - 1023 2024.2
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Nature
Increased blood pressure variability (BPV) was shown to be associated with cardiovascular morbidities and/or mortalities. There are various types of BPV depending on time intervals of BP measurements, ranging from beat-to-beat to visit-to-visit or year-to-year. We previously found that continuous infusion of noradrenaline (NA) for 14 days increased short-term BPV every 15 min in rats. The aims of this study were to examine (1) whether NA infusion increases very short-term beat-to-beat BPV, (2) the effects of azelnidipine and hydralazine on NA-induced BPV, and (3) whether baroreceptor reflex sensitivity (BRS) is affected by NA or NA plus those vasodilators. Nine-week-old Wistar rats infused subcutaneously with 30 μg/h NA were orally treated with or without 9.7 mg/day azelnidipine or 5.9 mg/day hydralazine over 14 days. BP levels were continuously monitored via abdominal aortic catheter with a telemetry system in an unrestrained condition. Standard deviations (SDs) were used to evaluate beat-to-beat BPV and BPV every 15 min which was obtained by averaging BP levels for 10-s segment at each time point. BRS was determined by a sequence analysis. Continuous NA infusion over 14 days increased average BP, beat-to-beat BPV, and BPV every 15 min, lowering BRS. Comparing the two vasodilators, hydralazine reduced BP elevation by NA; meanwhile, azelnidipine alleviated BPV augmentation, preserving BRS, despite a smaller BP reduction. Thus, NA infusion increased both very short- and short-term BPV concomitantly with impaired BRS, while azelnidipine had an inhibitory effect, possibly independent of BP-lowering, on those types of BPV and impairment of BRS.
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Diversity of Androgens; Comparison of Their Significance and Characteristics in Vertebrate Species Reviewed
Yazawa T., Imamichi Y., Sato T., Ida T., Umezawa A., Kitano T.
Zoological Science 41 ( 1 ) 77 - 86 2024.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Zoological Science
Androgen(s) is one of the sex steroids that are involved in many physiological phenomena of vertebrate species. Although androgens were originally identified as male sex hormones, it is well known now that they are also essential in females. As in the case of other steroid hormones, androgen is produced from cholesterol through serial enzymatic reactions. Although testis is a major tissue to produce androgens in all species, androgens are also produced in ovary and adrenal (interrenal tissue). Testosterone is the most common and famous androgen. It represents a major androgen both in males and females of almost vertebrate species. In addition, testosterone is a precursorforproducingsignificantandrogenssuchas11-ketotestosterone,5α-dihydrotestosterone, 11-ketodihydrotestosterones and 15α-hydroxytestosterone in a species- or sex-dependent manner for their homeostasis. In this article, we will review the significance and characteristics of these androgens, following a description of the history of testosterone discovery and its synthetic pathways.
DOI： 10.2108/zs230064
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Izumi T., Saito A., Ida T., Mukuda T., Katayama Y., Wong M.K.S., Tsukada T.
Cell and Tissue Research 396 ( 2 ) 197 - 212 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：Cell and Tissue Research
The natriuretic peptide (NP) family consists of cardiac NPs (ANP, BNP, and VNP) and brain NPs (CNPs) in teleosts. In addition to CNP1-4, a paralogue of CNP4 (named CNP4b) was recently discovered in basal teleosts including Japanese eel. Mammals have lost most Cnps during the evolution, but teleost cnps were conserved and diversified, suggesting that CNPs are important hormones for maintaining brain functions in teleost. The present study evaluated the potency of each Japanese eel CNP to their NP receptors (NPR-A, NPR-B, NPR-C, and NPR-D) overexpressed in CHO cells. A comprehensive brain map of cnps- and nprs-expressing neurons in Japanese eel was constructed by integrating the localization results obtained by in situ hybridization. The result showed that CHO cells expressing NPR-A and NPR-B induced strong cGMP productions after stimulation by cardiac and brain NPs, respectively. Regarding brain distribution of cnps, cnp1 is engaged in the ventral telencephalic area and periventricular area including the parvocellular preoptic nucleus (Pp), anterior/posterior tuberal nuclei, and periventricular gray zone of the optic tectum. cnp3 is found in the habenular nucleus and prolactin cells in the pituitary. cnp4 is expressed in the ventral telencephalic area, while cnp4b is expressed in the motoneurons in the medullary area. Such CNP isoform-specific localizations suggest that function of each CNP has diverged in the eel brain. Furthermore, the Pp lacking the blood-brain barrier expressed both npra and nprb, suggesting that endocrine and paracrine NPs interplay for regulating the Pp functions in Japanese eels.
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Acyl modifications in bovine, porcine, and equine ghrelins Reviewed
Ida T., Tominaga H., Iwamoto E., Kurogi A., Okura A., Shimada K., Kato J., Kuwano A., Ode H., Nagata S., Kitamura K., Yazawa T., Sato-Hashimoto M., Yasuda M., Miyazato M., Shiimura Y., Sato T., Kojima M.
Frontiers in Endocrinology 15 1411483 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers in Endocrinology
Ghrelin is a peptide hormone with various important physiological functions. The unique feature of ghrelin is its serine 3 acyl-modification, which is essential for ghrelin activity. The major form of ghrelin is modified with n-octanoic acid (C8:0) by ghrelin O-acyltransferase. Various acyl modifications have been reported in different species. However, the underlying mechanism by which ghrelin is modified with various fatty acids remains to be elucidated. Herein, we report the purification of bovine, porcine, and equine ghrelins. The major active form of bovine ghrelin was a 27-amino acid peptide with an n-octanoyl (C8:0) modification at Ser3. The major active form of porcine and equine ghrelin was a 28-amino acid peptide. However, porcine ghrelin was modified with n-octanol (C8:0), whereas equine ghrelin was modified with n-butanol (C4:0) at Ser3. This study indicates the existence of structural divergence in ghrelin and suggests that it is necessary to measure the minor and major forms of ghrelin to fully understand its physiology.
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Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats Reviewed
Jiang D., Matsuzaki M., Ida T., Kitamura K., Tsuruda T., Kaikita K., Kato J.
Peptides 166 171035 2023.8
Language：English Publishing type：Research paper (scientific journal) Publisher：Peptides
Excessive activation of the sympathetic nervous system is involved in cardiovascular damage including cardiac hypertrophy. Natriuretic peptides are assumed to exert protective actions for the heart, alleviating hypertrophy and/or fibrosis of the myocardium. In contrast to this assumption, we show in the present study that both atrial and C-type natriuretic peptides (ANP and CNP) potentiate cardiac hypertrophic response to noradrenaline (NA) in rats. Nine-week-old male Wistar rats were continuously infused with subcutaneous 30 micro-g/h NA without or with persistent intravenous administration of either 1.0 micro-g/h ANP or CNP for 14 days. Blood pressure (BP) was recorded under an unrestrained condition by a radiotelemetry system. Cardiac hypertrophic response to NA was evaluated by heart weight/body weight (HW/BW) ratio and microscopic measurement of myocyte size of the left ventricle. Mean BP levels at the light and dark cycles rose by about 20 mmHg following NA infusion for 14 days, with slight increases in HW/BW ratio and ventricular myocyte size. Infusions of ANP and CNP had no significant effects on mean BP in NA-infused rats, while two natriuretic peptides potentiated cardiac hypertrophic response to NA. Cardiac hypertrophy induced by co-administration of NA and ANP was attenuated by treatment with prazosin or atenolol. In summary, both ANP and CNP potentiated cardiac hypertrophic effect of continuously infused NA in rats, suggesting a possible pro-hypertrophic action of natriuretic peptides on the heart.
MISC 【 display / non-display 】
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消化管関連ペプチドが拓く恒常性フロンティア Invited
佐藤貴弘、井田隆徳、関口俊男、中町智哉、児島将康
実験医学 37 ( 3 ) 1 - 8 2019
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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Role of biological rhythms in the performance of physical activity Invited Reviewed
Sato T, Ida T, Kojima M
The Journal of Physical Fitness and Sports Medicine 6 ( 3 ) 125 - 134 2017.3
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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モデル生物を利用した新規摂食調節ペプチドの探索
井田隆徳
生物科学 2016.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：農山漁村文化協会
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Sano H., Nakamura A., Texada M., Truman J., Ishimoto H., Kamikouchi A., Nibu Y., Kume K., Ida T., Kojima M.
PLoS Genetics 11 ( 9 ) 2015.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：PLoS Genetics
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摂食調節ペプチドと飢餓応答
佐藤貴弘、井田隆徳、児島将康
The lipid 26 ( 1 ) 35 - 39 2015.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：メディカルレビュー社
Presentations 【 display / non-display 】
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動物介在活動から考えるOne Health Invited
井田隆徳
第１６６回日本獣医学会学術集会
Event date： 2023.9.5
Presentation type：Oral presentation (general)
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新規生理活性ペプチドの探索と応用 Invited
井田隆徳
第70回日本心臓病学会学術集会 2022.9.23
Event date： 2022.9.23
Language：Japanese Presentation type：Oral presentation (general)
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ホルモンとライフステージ：生物の生理学的変化と適応のダイナミズム
井田隆徳、長谷川和哉
第101回日本生理学会大会
Event date： 2024.3.28
Presentation type：Symposium, workshop panel (public)
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ウナギ脳に作用するナトリウム利尿ペプチドの内分泌・傍分泌経路の特定
和泉知輝、齋藤あみ、井田隆徳、椋田崇生、片山侑駿、Marty Kwok-Shing Wong、塚田岳大
第47回日本比較内分泌学会大会
Event date： 2023.11.17
Presentation type：Oral presentation (general)
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新規生理活性ペプチドの探索
井田隆徳
第１3回ペプチド・ホルモン研究会
Event date： 2023.9.30
Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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日本獣医学会生理学・生化学分科会奨励賞
2010.9 日本獣医学会
井田隆徳
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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11th International Conference on Human-Animal Interactions.Best Poster Award
2007.10 IAHAIO
Yoshidomi Y, Ikeda Y, Satoh H, Sekino R, Ida T, Hisatomi I, Nakatsuka K, Misawa N
Award type：Award from international society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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摂食・エネルギー代謝を制御する新規生理活性ペプチドの発見と応用
Grant number：21K05958 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究C
Authorship：Principal investigator
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生体必須の金属補因子「鉄硫黄クラスター」の生合成機序と無細胞構築系の確立
Grant number：20H03196 2020.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究（B）
Authorship：Coinvestigator(s)
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難治性の神経因性疼痛を抑制する脳由来新規生理活性物質の構造決定と生理作用の解析
Grant number：20K07768 2020.04 - 2023.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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新規NPY様RYamideペプチドの発見と食欲調節機構の解析
2017.04 - 2020.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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昆虫における食欲促進/減退を引き起こす生理活性ペプチドの発見
2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
昆虫における食欲促進/減退を引き起こす生理活性ペプチドの発見し解析する
Other research activities 【 display / non-display 】
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食鳥処理施設での骨髄のサンプリング
2023.11
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食鳥処理施設での脳のサンプリング
2019.07
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食鳥処理施設での肝臓のサンプリング
2018.06
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食肉処理施設における膵臓のサンプリング
2017.07
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食鳥処理施設での脳のサンプリング
2017.05
Available Technology 【 display / non-display 】
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新規生理活性ペプチドの探索
新規生理活性ペプチドの機能解析
病態モデル生物の作製Related fields where technical consultation is available：ペプチド抽出
受容体発現細胞を用いたセカンドメッセンジャーアッセイMessage：宮崎大学の伝統あるペプチド研究を引き継ぎ、ペプチド研究におけるプラットフォームを目指しています。