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Affiliation |
Faculty of Medicine College Hospital Department of radiology |
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JINNOUCHI Takashi
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Papers 【 display / non-display 】
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Yamada A., Kinoshita M., Kamimura S., Jinnouchi T., Azuma M., Yamashita S., Yokogami K., Takeshima H., Moritake H.
Pediatric Hematology and Oncology 40 ( 7 ) 629 - 642 2023
Language：English Publishing type：Research paper (scientific journal) Publisher：Pediatric Hematology and Oncology
Atypical teratoid/rhabdoid tumor (AT/RT) is a rare aggressive central nervous system tumor that typically affects children under three years old and has poor survival with a high risk for neurologic deficits. The primary purpose of this study was to successfully treat the disease and delay or avoid whole-brain radiotherapy for children with AT/RT. A retrospective analysis was performed for six children diagnosed with AT/RT and treated with multimodal treatment at a single institute between 2014 and 2020. Furthermore, germline SMARCB1 aberrations and MGMT methylation status of the tumors were analyzed. One patient who did not receive a modified IRS-III regimen replaced with ifosphamide, carboplatin, and etoposide (ICE) in induction chemotherapy was excluded from this analysis. Five patients who received ICE therapy were under three years old. After a surgical approach, they received intensive chemotherapy and high-dose chemotherapy with autologous peripheral blood stem cell transplantation (HDCT/autoPBSCT) followed by intrathecal topotecan maintenance therapy. Three patients underwent single HDCT/autoPBSCT, and the other two received sequential treatment. Two patients with germline SMARCB1 aberrations and metastases died of progressive AT/RT or therapy-related malignancy, while 3 with localized tumors without germline SMARCB1 aberrations remained alive. One survivor received local radiotherapy only, while the other two did not undergo radiotherapy. All three surviving patients were able to avoid whole-brain radiotherapy. Our results suggest that AT/RT patients with localized tumors without germline SMARCB1 aberrations can be rescued with multimodal therapy, including induction therapy containing ICE followed by HDCT/autoPBSCT and intrathecal topotecan maintenance therapy without radiotherapy. Further large-scale studies are necessary to confirm this hypothesis.
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Kuga N., Shirieda K., Sato Y., Shimotabira H., Kurogi Y., Jinnouchi T.
Journal of Medical Physics 47 ( 1 ) 79 - 85 2022.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Medical Physics
Purpose: The purpose of he study was to reduce setup errors during intensity-modulated radiation therapy (IMRT) with an original knee fixation device (KFD) and evaluate the clinical target volume (CTV) coverage. Methods: Participants were classified into two groups: knee flexion (KF) group (n = 16), wherein participants' knees were fixed in a flexed position using the proposed KFD during planning computed tomography, and knee extension group (KE; n = 15), wherein no KFD was used. We investigated the residual rotational errors and inter-fractional setup errors with or without KFD. Furthermore, inter-fractional margins were calculated using logistic regression analysis, and CTV coverage was evaluated. Results: The residual rotational errors in the yaw and roll directions (P < 0.02) and the inter-fractional error in the anterior-posterior (A-P) direction (P < 0.02) improved significantly in the KF group compared with the KE group. Repeatability was improved for the pitch direction. The inter-fractional margins were 6.68 mm and 4.87 mm in the A-P and superior-inferior (S-I) directions, respectively, in the KF group, representing reductions (mm) of 20.8% and 12.6% compared with the KE group, respectively. The odds ratios for CTV coverage in the KF group compared to the KE group were 2.76 (P < 0.001) and 1.74 (P < 0.05) in the A-P and S-I directions, respectively. Conclusions: The IMRT fixation method using an original KFD improved the residual rotational error in the three directions and the inter-fractional error in the A-P direction, reduced the interfractional margins in the A-P, and S-I directions and improved CTV coverage. Our original KFD may be a useful fixation method during prostate IMRT.
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けいれん重積型急性脳症と鑑別を要した乳児揺さぶり症候群の1例 Reviewed
服部洋平、門田善仁、東 美菜子、陣内 崇、平井俊範
宮崎県医師会医学会誌 42 ( 2 ) 207 - 211 2018.12
Publishing type：Research paper (scientific journal) Publisher：宮崎県医師会
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低管電圧撮影技術を用いた放射線治療計画CT の被ばく低減の有用性 Reviewed
鴻野拓哉、久家教幸、圓﨑将大、山下勇貴、北里裕美子、下田平春彦、陣内 崇、楠原和朗、川村慎二
日本放射線技術学会雑誌 71 ( 4 ) 308 - 315 2015.4
Publishing type：Research paper (scientific journal) Publisher：日本放射線技術学会
Presentations 【 display / non-display 】
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放射線療法概論
陣内 崇
令和4年度宮崎大学がんセミナー
Event date： 2022.10.19
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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放射線療法概論
陣内 崇
令和2年度 宮崎大学がんセミナー (宮崎県宮崎市)
Event date： 2020.10.28
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
Venue：宮崎県宮崎市
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当施設施行の頭頸部癌に対するIMRTによる放射線治療の評価
楠原和朗、井手貴一、陣内 崇、平井俊範、東野哲也、山下善弘
日本放射線腫瘍学会 第32回学術大会 (愛知県名古屋市)
Event date： 2019.11.21 - 2019.11.23
Language：Japanese Presentation type：Poster presentation
Venue：愛知県名古屋市
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放射線療法概論
陣内 崇
令和元年度 宮崎大学がんセミナー (宮崎県宮崎市)
Event date： 2019.11.13
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
Venue：宮崎県宮崎市
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放射線治療が奏功した肝細胞癌門脈塞栓の2症例
井手貴一、陣内 崇、楠原和朗、平井俊範
第187回日本医学放射線学会九州地方会 (熊本県熊本市)
Event date： 2018.6.23 - 2018.6.24
Language：Japanese Presentation type：Oral presentation (general)
Venue：熊本県熊本市
Other research activities 【 display / non-display 】
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放射線治療用固定具開発・作成
2010.04
放射線治療にける患者固定具に関し、より固定精度が高く、かつ安価な物品の開発、作成。