陣内 崇 (ジンノウチ タカシ)

JINNOUCHI Takashi

写真a

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医学部 附属病院 放射線科

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  • Novel Strategy Involving High-Dose Chemotherapy with Stem Cell Rescue Followed by Intrathecal Topotecan Maintenance Therapy without Whole-Brain Irradiation for Atypical Teratoid/Rhabdoid Tumors 査読あり

    Yamada A., Kinoshita M., Kamimura S., Jinnouchi T., Azuma M., Yamashita S., Yokogami K., Takeshima H., Moritake H.

    Pediatric Hematology and Oncology   40 ( 7 )   629 - 642   2023年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Pediatric Hematology and Oncology  

    Atypical teratoid/rhabdoid tumor (AT/RT) is a rare aggressive central nervous system tumor that typically affects children under three years old and has poor survival with a high risk for neurologic deficits. The primary purpose of this study was to successfully treat the disease and delay or avoid whole-brain radiotherapy for children with AT/RT. A retrospective analysis was performed for six children diagnosed with AT/RT and treated with multimodal treatment at a single institute between 2014 and 2020. Furthermore, germline SMARCB1 aberrations and MGMT methylation status of the tumors were analyzed. One patient who did not receive a modified IRS-III regimen replaced with ifosphamide, carboplatin, and etoposide (ICE) in induction chemotherapy was excluded from this analysis. Five patients who received ICE therapy were under three years old. After a surgical approach, they received intensive chemotherapy and high-dose chemotherapy with autologous peripheral blood stem cell transplantation (HDCT/autoPBSCT) followed by intrathecal topotecan maintenance therapy. Three patients underwent single HDCT/autoPBSCT, and the other two received sequential treatment. Two patients with germline SMARCB1 aberrations and metastases died of progressive AT/RT or therapy-related malignancy, while 3 with localized tumors without germline SMARCB1 aberrations remained alive. One survivor received local radiotherapy only, while the other two did not undergo radiotherapy. All three surviving patients were able to avoid whole-brain radiotherapy. Our results suggest that AT/RT patients with localized tumors without germline SMARCB1 aberrations can be rescued with multimodal therapy, including induction therapy containing ICE followed by HDCT/autoPBSCT and intrathecal topotecan maintenance therapy without radiotherapy. Further large-scale studies are necessary to confirm this hypothesis.

    DOI: 10.1080/08880018.2023.2220734

    Scopus

    PubMed

  • Original knee fixation device as a useful fixation method during prostate intensity-modulated radiation therapy

    Kuga N., Shirieda K., Sato Y., Shimotabira H., Kurogi Y., Jinnouchi T.

    Journal of Medical Physics   47 ( 1 )   79 - 85   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Medical Physics  

    Purpose: The purpose of he study was to reduce setup errors during intensity-modulated radiation therapy (IMRT) with an original knee fixation device (KFD) and evaluate the clinical target volume (CTV) coverage. Methods: Participants were classified into two groups: knee flexion (KF) group (n = 16), wherein participants' knees were fixed in a flexed position using the proposed KFD during planning computed tomography, and knee extension group (KE; n = 15), wherein no KFD was used. We investigated the residual rotational errors and inter-fractional setup errors with or without KFD. Furthermore, inter-fractional margins were calculated using logistic regression analysis, and CTV coverage was evaluated. Results: The residual rotational errors in the yaw and roll directions (P < 0.02) and the inter-fractional error in the anterior-posterior (A-P) direction (P < 0.02) improved significantly in the KF group compared with the KE group. Repeatability was improved for the pitch direction. The inter-fractional margins were 6.68 mm and 4.87 mm in the A-P and superior-inferior (S-I) directions, respectively, in the KF group, representing reductions (mm) of 20.8% and 12.6% compared with the KE group, respectively. The odds ratios for CTV coverage in the KF group compared to the KE group were 2.76 (P < 0.001) and 1.74 (P < 0.05) in the A-P and S-I directions, respectively. Conclusions: The IMRT fixation method using an original KFD improved the residual rotational error in the three directions and the inter-fractional error in the A-P direction, reduced the interfractional margins in the A-P, and S-I directions and improved CTV coverage. Our original KFD may be a useful fixation method during prostate IMRT.

    DOI: 10.4103/jmp.jmp_117_21

    Scopus

    PubMed

  • けいれん重積型急性脳症と鑑別を要した乳児揺さぶり症候群の1例 査読あり

    服部洋平、門田善仁、東 美菜子、陣内 崇、平井俊範

    宮崎県医師会医学会誌   42 ( 2 )   207 - 211   2018年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:宮崎県医師会  

  • 低管電圧撮影技術を用いた放射線治療計画CT の被ばく低減の有用性 査読あり

    鴻野拓哉、久家教幸、圓﨑将大、山下勇貴、北里裕美子、下田平春彦、陣内 崇、楠原和朗、川村慎二

    日本放射線技術学会雑誌   71 ( 4 )   308 - 315   2015年4月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:日本放射線技術学会  

講演・口頭発表等 【 表示 / 非表示

  • 放射線療法概論

    陣内 崇

    令和4年度宮崎大学がんセミナー 

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    開催年月日: 2022年10月19日

    記述言語:日本語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

  • 放射線療法概論

    陣内 崇

    令和2年度 宮崎大学がんセミナー  (宮崎県宮崎市) 

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    開催年月日: 2020年10月28日

    記述言語:日本語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

    開催地:宮崎県宮崎市  

  • 当施設施行の頭頸部癌に対するIMRTによる放射線治療の評価

    楠原和朗、井手貴一、陣内 崇、平井俊範、東野哲也、山下善弘

    日本放射線腫瘍学会 第32回学術大会  (愛知県名古屋市) 

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    開催年月日: 2019年11月21日 - 2019年11月23日

    記述言語:日本語   会議種別:ポスター発表  

    開催地:愛知県名古屋市  

  • 放射線療法概論

    陣内 崇

    令和元年度 宮崎大学がんセミナー  (宮崎県宮崎市) 

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    開催年月日: 2019年11月13日

    記述言語:日本語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

    開催地:宮崎県宮崎市  

  • 放射線治療が奏功した肝細胞癌門脈塞栓の2症例

    井手貴一、陣内 崇、楠原和朗、平井俊範

    第187回日本医学放射線学会九州地方会  (熊本県熊本市) 

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    開催年月日: 2018年6月23日 - 2018年6月24日

    記述言語:日本語   会議種別:口頭発表(一般)  

    開催地:熊本県熊本市  

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その他研究活動 【 表示 / 非表示

  • 放射線治療用固定具開発・作成

    2010年04月 - 現在

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    放射線治療にける患者固定具に関し、より固定精度が高く、かつ安価な物品の開発、作成。