XU Yan

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Medical Sciences, Chemistry

Title

Professor

External Link

Degree 【 display / non-display

  • Doctor(Medicine) ( 2004.3   Tokyo Medical and Dental University )

Research Areas 【 display / non-display

  • Nanotechnology/Materials / Chemical biology

 

Papers 【 display / non-display

  • ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis Reviewed International coauthorship International journal

    Ting Zhang, Chaoran Yin, Aleksandr Fedorov, Liangjun Qiao, Hongliang Bao, Nazar Beknazarov, Shiyu Wang, Avishekh Gautam, Riley M. Williams, Jeremy Chase Crawford, Suraj Peri, Vasily Studitsky, Amer A. Beg, Paul G. Thomas, Carl Walkley, Yan Xu, Maria Poptsova, Alan Herbert and Siddharth Balachandran

    Nature   1 - 9   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41586-022-04753-7

  • A Small Ligand That Selectively Binds to the G-quadruplex at the Human Vascular Endothelial Growth Factor Internal Ribosomal Entry Site and Represses the Translation Reviewed International coauthorship

    Xiao-Xia Hu, Sheng-Quan Wang, Shi-Quan Gan1, Lei Liu, Ming-Qing Zhong, Meng-Hao Jia, Fei Jiang, Yan Xu, Chao-Da Xiao*,and Xiang-Chun Shen*

    Frontiers in Chemistry   9   781198   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fchem.2021.781198

  • Systematic Approach to DNA Aptamer Design Using Amino Acid-Nucleic Acid Hybrids (ANHs) Targeting Thrombin Reviewed

    J. H.Yum, T. Ishizuka, H. L. Bao, K. Fukumoto, D.Hori, Y. Xu, H. Sugiyama, S. Park

    ACS Biomater Sci Eng.   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Observation of Z‐DNA Structure via the Synthesis of Oligonucleotide DNA Containing 8‐Trifluoromethyl‐2‐Deoxyguanosine Reviewed

    Hong‐Liang Bao, Yan Xu

    Current Protocols   1 ( e28 )   1 - 14   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cpz1.28

  • Improving Thermodynamic Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Incorporation of 8-trifluoromethyl-2′-deoxyguanosine Reviewed

    Hong-Liang Bao, Takumi Ishizuka, Atsushi Yamashita, Eiji Furukoji, Yujiro Asada, and Yan Xu*

    Journal of Medicinal Chemistry   64 ( 1 )   711 - 718   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jmedchem.0c01711

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Books 【 display / non-display

  • 核酸科学ハンドブック(第II部 核酸科学の最前線 3. グアニン四重鎖構造)

    徐岩( Role: Contributor ,  第II部 核酸科学の最前線 3. グアニン四重鎖構造)

    講談社  2020.12  ( ISBN:978-4065207864

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    Total pages:576   Language:Japanese Book type:Scholarly book

  • G-Quadruplex Nucleic Acids (Chapter 26: 19F NMR Spectroscopy for the Analysis of DNA G-Quadruplex Structures Using 19F-Labeled Nucleobase)

    T. Ishizuka, H. L. Bao, Y. Xu*( Role: Joint author)

    Springer  2019.8 

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    Total pages:pp 407-433   Language:English Book type:Scholarly book

  • Clipping of Telomere from Human Chromosomes Using a Chemistry-Based Artificial Restriction DNA Cutter(共著)

    Takumi Ishizuka, Yan Xu, Makoto Komiyama( Role: Joint author)

    John Wiley & Sons, Inc.  2015.6 

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    Language:English

  • DNA Conjugates and Sensors (Chapter 12: Covalent and Non-covalent Conjugates of Oligonucleotide as Artifical Restriction DNA Cutters)

    M. Komiyama, Y. Xu and J. Sumaoka( Role: Joint author)

    Royal Society of Chemistry  2012.10 

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    Language:English Book type:Scholarly book

  • Human Telomeres: Structure, Function and Targeting of Telomere DNA/RNA

    Yan Xu( Role: Sole author)

    Royal Society Of Chemistry  2011.11 

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    Language:English Book type:Scholarly book

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MISC 【 display / non-display

  • Human telomere DNA / RNA G-quadruplex and cancer therapy development Invited

    2020.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Human Telomere RNA Structure and Function Reviewed

    Y. Xu

    Telomere and Telomerase   3   2016.11

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.14800/tt.1455

  • 化学の目で、ヒトテロメアの謎を解く(共著)

    徐岩

    日本化学会生体関連部会ニュースレター   26 ( 1 )   3 - 6   2011.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)   Publisher:日本化学会  

  • G-カルテット安定化分子でテロメラーゼを阻害する

    Shinohara,K., Xu,Y., Sugiyama,H

    化学   60 ( 7 )   68 - 69   2005.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:化学同人  

Presentations 【 display / non-display

  • Dimerization of COVID-19 mRNA formed by an unusual topological RNA G-quadruplex International conference

    Yi Song, Shiyu Wang, Yan Xu

    第48回国際核酸化学シンポジウム  2021.11.11 

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    Event date: 2021.11.10 - 2021.11.12

    Language:English   Presentation type:Poster presentation  

  • Phase Transitions in the Assembly of Trifluoromethylated G-quadruplex RNA by shorter CGG Trinucleotide Repeats International conference

    Shiyu Wang, Yan Xu

    第48回国際核酸化学シンポジウム  2021.11.11 

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    Event date: 2021.11.10 - 2021.11.12

    Language:English   Presentation type:Oral presentation (general)  

  • RNA二重鎖から形成される新規RNA G-quadruplex:COVID-19 mRNAの二量体化への影響

    徐岩、宋藝、王詩宇

    第15回バイオ関連化学シンポジウム  2021.9.10 

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    Event date: 2021.9.8 - 2021.9.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 8-Trifluoromethylated RNA composed of CGG trinucleotide repeats: synthesis, structure and

    Shiyu Wang, Hongliang Bao, Yan Xu

    日本ケミカルバイオロジー学会第15回年会  2021.6.22 

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    Event date: 2021.6.21 - 2021.6.23

    Language:English   Presentation type:Poster presentation  

  • A novel architecture of RNA G-quadruplex formed by SARS Cov-2 RNA

    Yi Song, Shi-Yu Wang, Hong-Liang Bao, Yan Xu

    日本ケミカルバイオロジー学会第15回年会  2021.6.23 

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    Event date: 2021.6.21 - 2021.6.23

    Language:English   Presentation type:Oral presentation (general)  

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Awards 【 display / non-display

  • 宮崎大学ハイステップ研究者

    2019.2   宮崎大学  

    徐岩

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    Award type:International academic award (Japan or overseas)  Country:Japan

  • 光科学技術研究振興財団研究奨励金

    2018.2   光科学技術研究振興財団  

    徐岩

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

  • 宮崎大学ハイステップ研究者

    2016.12   宮崎大学  

    徐岩

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    Country:Japan

  • 武田科学振興財団研究奨励金

    2013.8   武田科学振興財団  

    徐岩

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

  • 内藤記念科学振興財団研究奨励金

    2011.12   内藤記念科学振興財団  

    徐岩

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

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Grant-in-Aid for Scientific Research 【 display / non-display

  • テロメアRNA構造と反応性及びそれを活用したテロメアを標的とする新規癌治療の開発

    2017.04 - 2020.03

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  • 19F NMR分子技術の開発によるヒト細胞内DNA及びRNA高次構造の解明

    Grant number:21H02081  2021.04 - 2024.03

    独立行政法人日本学術振興会  基盤研究(B)

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    Authorship:Principal investigator 

  • 分子結合技術を用いた造影剤による革新的がんCT 画像化技術の開発

    2019.04 - 2022.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • 胆管癌の局所制御増強と光線過敏軽減による普及を目指した次世代光線力学的療法の開発

    Grant number:19K09178  2019.04 - 2022.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • 化学ツールを活用したヒトゲノムの修飾・損傷の精密検出とニュー・ゲノム科学の創成

    2015.04 - 2018.03

    科学研究費補助金  基盤研究(A)

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    Authorship:Coinvestigator(s) 

    第2世代のスーパー制限酵素の構成要素となるPNAの化学修飾法ならびにDNA切断後のアフィニティー分離法を最適化し、高収率かつ高純度にDNA断片を得る方法を確立する。さらに、得られたDNA断片を解析し修飾塩基や酸化損傷塩基の定量的な情報を入手し、本手法の妥当性ならびに有用性を実証する。

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Other research activities 【 display / non-display

  • Advisory Board of Sci

    2018.01

  • Editorial Board of Molecules

    2017.04

  • "Faculty of 1000"のメンバー

    2008.04

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    "Faculty of 1000" とは、生物学と医学研究の出版物において、最も重要だと思われる論文を認定し評価を与える国際学術組織です。