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Affiliation |
Faculty of Medicine College Hospital Hemocatharsis treatment part |
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Associate Professor |
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Related SDGs |
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KIKUCHI Masao
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Papers 【 display / non-display 】
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Ishizaki Y.S., Kikuchi M., Kaikita K., Fujimoto S.
Physiological Reports 12 ( 21 ) e70121 2024.11
Language：English Publishing type：Research paper (scientific journal) Publisher：Physiological Reports
The kidneys are essential for glucose homeostasis, as they perform gluconeogenesis, utilize glucose, and reabsorb glucose. Reabsorption is performed by SGLT2, which is responsible for about 90%. However, little is known about how renal glucose handling is altered in patients with chronic kidney disease (CKD). SGLT2 inhibitors have demonstrated efficacy in suppressing CKD progression in clinical trials, but their mechanisms are not fully understood. Therefore, this study aimed to evaluate how each uninephrectomy (UNx) and SGLT2 inhibitor affects blood glucose concentrations and SGLTs dynamics in rats with type 2 diabetes mellitus. Male rats were divided into four treatment groups: sham + placebo, sham + dapagliflozin, UNx + placebo, and UNx + dapagliflozin. There were few group differences in food intake or body weight, but blood glucose concentrations continued to rise in the sham + placebo, whereas this rise was delayed for several weeks in the UNx + placebo, and largely suppressed by dapagliflozin. SGLT2 mRNA expression was significantly lower in the UNx group, but SGLT1 mRNA expression did not significantly differ. Dapagliflozin did not alter SGLT1 or SGLT2 mRNA expression. In animal models of diabetes, renal glucose reabsorption appears likely to be a major contributor to the development of hyperglycemia.
DOI： 10.14814/phy2.70121
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Ochiai S., Kikuchi M., Kaikita K.
Kidney360 5 ( 6 ) 927 - 928 2024.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Kidney360
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落合 彰子, 菊池 正雄, 海北 幸一, 藤元 昭一
Journal of Nephrology 2024.2
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Nature
Citation:
Ochiai, S., Kikuchi, M., Kaikita, K. et al. Rapidly progressive glomerulonephritis due to IgA nephropathy accompanied by collagenofibrotic glomerulopathy. A nephrology picture. J Nephrol (2024). https://doi.org/10.1007/s40620-023-01875-7 -
Ochiai Shoko, Iwakiri Takashi, Kikuchi Masao, Kaikita Koichi, Fujimoto Shouichi
Nihon Toseki Igakkai Zasshi 57 ( 1 ) 29 - 35 2024
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Dialysis Therapy
A 71-year-old male presented in 2012 with symptoms of alveolar hemorrhage, abnormal urine analysis, and renal dysfunction (serum creatinine level：4 mg/dL). The patient was positive for MPO-ANCA. Renal biopsy revealed crescentic glomerulonephritis, and he was diagnosed with ANCA-associated vasculitis. Treatment with prednisolone and various immunosuppressive drugs resolved the alveolar hemorrhage and improved the creatinine level to around 2 mg/dL. In March 2017, the patient was treated for alveolar hemorrhage with methylprednisolone pulse therapy. His renal function gradually worsened, and in October 2017, hemodialysis was initiated. At the time of initiation, alveolar hemorrhage was present, and the patient received methylprednisolone pulse therapy. Within a few days, the bloody sputum disappeared, and there were no respiratory symptoms. He had been taking trimethoprim-sulfamethoxazole to prevent pneumocystis pneumonia for a prolonged period and continued to take the drug after admission (80 mg of trimethoprim twice a week). However, on the 19<sup>th</sup> day, a nodule shadow appeared in the right middle lung field on plain chest X-ray and it was enlarging. No respiratory symptoms were present, but <i>Nocardia</i> was identified via sputum culture, ultimately leading to a diagnosis of pulmonary nocardiosis. The background of steroid therapy and induction of dialysis were considered to be the trigger for pulmonary nocardiosis in this case. Treatment with trimethoprim-sulfamethoxazole was initiated, and the nodule shadow reduced. In the early stages of dialysis initiation, there is a well-known higher incidence of tuberculosis due to cellular immunosuppression. In dialysis-initiated patients undergoing immunosuppressive therapy, <i>Nocardia</i> infection should also be considered.
DOI： 10.4009/jsdt.57.29
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Ochiai S., Kikuchi M., Kaikita K., Fujimoto S.
Journal of Nephrology 37 ( 5 ) 1383 - 1386 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Nephrology
Books 【 display / non-display 】
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第7章 患者管理。慢性腎臓病に伴う骨・ミネラル代謝異常
藤元昭一、菊池 正雄（ Role： Contributor）
医歯薬出版株式会社 2019.3
Language：Japanese Book type：Scholarly book
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第7章 患者管理。慢性腎臓病に伴う骨・ミネラル代謝異常
藤元昭一、菊池 正雄（ Role： Contributor）
医歯薬出版株式会社 2019.3
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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閉塞性動脈硬化症に対する腸骨動脈ステント留置後長期経過して感染性動脈瘤を発症し、コイル塞栓術を行った長期血液透析患者の一例
黒田彩加、落合彰子、植村倫行、海老原尚、佐藤祐二、菊池正雄、藤元昭一
九州人工透析研究会誌 2020.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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両側腎動脈狭窄症に対する治療
菊池正雄、古郷博紀、石﨑友梨、菅井亜希、新屋琴子、麻生久美子、皆川明大、西園隆三、稲垣浩子、石川哲憲、佐藤祐二、北村和雄、藤元昭一
宮崎県医師会医学会誌 2020.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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A case of encephalopathy presenting the lentiform fork sign on MRI in a diabetic dialysis patient - diabetic
Yuri Ishizaki, Ryuzoh Nishizono, Masao Kikuchi, Hiroko Inagaki, Yuji Sato, Shouichi Fujimoto
F1000Reserch 2020.8
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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IgA腎症
菊池正雄、佐藤祐二、藤元昭一
腎と透析 2020.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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急速進行性糸球体腎炎
菊池正雄
medicina 2020.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
Presentations 【 display / non-display 】
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Urine aquaporin-2 messenger RNA predicts global glomerulosclerosis and renal outcome in anti-neutrophil cytoplasmic antibody-associated vasculitis
Kikuchi M, Fukuda A, Minakawa A, Sato Y, Fujimoto S
ASN kidney Week 2019
Event date： 2019.11
Language：English Presentation type：Poster presentation
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両側大脳基底核病変を呈する代謝性脳症をきたした血液透析患者の一例
黒田彩加、石﨑友梨、西園隆三、菊池正雄、稲垣浩子、佐藤祐二、藤元昭一
第49回日本腎臓学会西部学術大会
Event date： 2019.10
Language：Japanese Presentation type：Poster presentation
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免疫チェックポイント阻害薬関連心筋炎との鑑別に苦慮したトロポニンＴ産生篩骨洞がんの一例
鶴田敏博、佐藤勇一郎、梶原啓、川畑隆之、久富木庸子、菊池正雄、石川哲憲、東野哲也、北村和雄
第2回日本腫瘍循環器学会学術集会
Event date： 2019.9.21 - 2019.9.22
Language：Japanese Presentation type：Poster presentation
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Ⅰ型糖尿病，微小変化型ネフローゼ症候群をほぼ同時期に発症し急性腎不全を呈した1例
櫛間菜津美、古郷博紀、石﨑友梨、新屋琴子、日髙竜太郎、崎原久美子、西園隆三、菊池正雄、佐藤祐二、藤元昭一
日本内科学会第326回九州地方会
Event date： 2019.8
Language：Japanese Presentation type：Poster presentation
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両側大脳基底核病変を呈する代謝性脳症をきたした血液透析患者の一例
石﨑友梨、西園隆三、菊池正雄、稲垣浩子、佐藤祐二、藤元昭一
第47回宮崎県人工透析研究会
Event date： 2019.7.27
Language：Japanese Presentation type：Poster presentation
Grant-in-Aid for Scientific Research 【 display / non-display 】
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循環器疾患の臓器障害におけるビッグアンジオテンシン-25の役割と生成機構の解明
Grant number：19K08543 2019.04 - 2022.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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循環器疾患の臓器障害におけるビッグアンジオテンシン-25の役割と生成機構の解明
Grant number：19K08543 2019.04 - 2022.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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循環器疾患の臓器障害におけるビッグアンジオテンシン-25の役割と生成機構の解明
Grant number：19K08543 2019.04 - 2022.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)