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Faculty of Medicine College Hospital Hemocatharsis treatment part |
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Associate Professor |
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Related SDGs |
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KIKUCHI Masao
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Papers 【 display / non-display 】
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Fujimoto K., Kikuchi M., Nakai M., Konta T., Iseki K., Tsuruya K., Yamagata K., Narita I., Moriyama T., Shibagaki Y., Kasahara M., Kondo M., Asahi K., Watanabe T., Kaikita K., Fujimoto S.
American Journal of Hypertension 38 ( 7 ) 476 - 484 2025.7
Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Hypertension
BACKGROUND Rapid decline in estimated glomerular filtration rate (eGFR) is linked to increased mortality and morbidity in chronic kidney disease (CKD). Few studies have focused on the risk of rapid eGFR decline. This study evaluates the association between antihypertensive drug use, blood pressure (BP) levels, and rapid eGFR decline in Japanese CKD patients. METHODS Data from 100,746 Japanese individuals aged 40-74 years with CKD were analyzed. Rapid eGFR decline was defined as an annual reduction > 25%. Logistic regression was used to assess associations between antihypertensive drug use, BP levels, and rapid eGFR decline, stratified by eGFR and urinary proteinuria. RESULTS Rapid eGFR decline occurred in 5.8% of participants. Higher BP levels increased the risk compared to normal BP: high-normal + elevated BP (odds ratio [OR], 1.26; 95% CI: 1.12-1.41) and high BP (OR, 1.79; 95% CI: 1.59-2.02). Controlling BP to high-normal or elevated levels in patients receiving antihypertensives reduced this risk. Overall, antihypertensive drug users had approximately twice the risk of rapid eGFR decline compared to nonusers. However, in proteinuric patients with preserved eGFR, the risk increase was lower (1.27 times) in the high-normal + elevated BP group compared to that in the overall cohort. CONCLUSIONS The risk of rapid eGFR decline increased with increasing BP and decreased with controlling BP. Antihypertensive treatment was associated with a higher risk of rapid eGFR decline at all BP levels. For CKD patients with proteinuria, maintaining BP in the high-normal or elevated range may further mitigate this risk.
DOI： 10.1093/ajh/hpaf041
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Ishizaki Y.S., Kikuchi M., Kaikita K., Fujimoto S.
Physiological Reports 12 ( 21 ) e70121 2024.11
Language：English Publishing type：Research paper (scientific journal) Publisher：Physiological Reports
The kidneys are essential for glucose homeostasis, as they perform gluconeogenesis, utilize glucose, and reabsorb glucose. Reabsorption is performed by SGLT2, which is responsible for about 90%. However, little is known about how renal glucose handling is altered in patients with chronic kidney disease (CKD). SGLT2 inhibitors have demonstrated efficacy in suppressing CKD progression in clinical trials, but their mechanisms are not fully understood. Therefore, this study aimed to evaluate how each uninephrectomy (UNx) and SGLT2 inhibitor affects blood glucose concentrations and SGLTs dynamics in rats with type 2 diabetes mellitus. Male rats were divided into four treatment groups: sham + placebo, sham + dapagliflozin, UNx + placebo, and UNx + dapagliflozin. There were few group differences in food intake or body weight, but blood glucose concentrations continued to rise in the sham + placebo, whereas this rise was delayed for several weeks in the UNx + placebo, and largely suppressed by dapagliflozin. SGLT2 mRNA expression was significantly lower in the UNx group, but SGLT1 mRNA expression did not significantly differ. Dapagliflozin did not alter SGLT1 or SGLT2 mRNA expression. In animal models of diabetes, renal glucose reabsorption appears likely to be a major contributor to the development of hyperglycemia.
DOI： 10.14814/phy2.70121
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Ochiai S., Kikuchi M., Kaikita K.
Kidney360 5 ( 6 ) 927 - 928 2024.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Kidney360
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落合 彰子, 菊池 正雄, 海北 幸一, 藤元 昭一
Journal of Nephrology 2024.2
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Nature
Citation:
Ochiai, S., Kikuchi, M., Kaikita, K. et al. Rapidly progressive glomerulonephritis due to IgA nephropathy accompanied by collagenofibrotic glomerulopathy. A nephrology picture. J Nephrol (2024). https://doi.org/10.1007/s40620-023-01875-7 -
Ochiai S., Kikuchi M., Kaikita K., Fujimoto S.
Journal of Nephrology 37 ( 5 ) 1383 - 1386 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Nephrology
Books 【 display / non-display 】
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第7章 患者管理。慢性腎臓病に伴う骨・ミネラル代謝異常
藤元昭一、菊池 正雄（ Role： Contributor）
医歯薬出版株式会社 2019.3
Language：Japanese Book type：Scholarly book
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第7章 患者管理。慢性腎臓病に伴う骨・ミネラル代謝異常
藤元昭一、菊池 正雄（ Role： Contributor）
医歯薬出版株式会社 2019.3
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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閉塞性動脈硬化症に対する腸骨動脈ステント留置後長期経過して感染性動脈瘤を発症し、コイル塞栓術を行った長期血液透析患者の一例
黒田彩加、落合彰子、植村倫行、海老原尚、佐藤祐二、菊池正雄、藤元昭一
九州人工透析研究会誌 2020.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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両側腎動脈狭窄症に対する治療
菊池正雄、古郷博紀、石﨑友梨、菅井亜希、新屋琴子、麻生久美子、皆川明大、西園隆三、稲垣浩子、石川哲憲、佐藤祐二、北村和雄、藤元昭一
宮崎県医師会医学会誌 2020.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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A case of encephalopathy presenting the lentiform fork sign on MRI in a diabetic dialysis patient - diabetic
Yuri Ishizaki, Ryuzoh Nishizono, Masao Kikuchi, Hiroko Inagaki, Yuji Sato, Shouichi Fujimoto
F1000Reserch 2020.8
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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IgA腎症
菊池正雄、佐藤祐二、藤元昭一
腎と透析 2020.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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急速進行性糸球体腎炎
菊池正雄
medicina 2020.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
Presentations 【 display / non-display 】
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Urine aquaporin-2 messenger RNA predicts global glomerulosclerosis and renal outcome in anti-neutrophil cytoplasmic antibody-associated vasculitis
Kikuchi M, Fukuda A, Minakawa A, Sato Y, Fujimoto S
ASN kidney Week 2019
Event date： 2019.11
Language：English Presentation type：Poster presentation
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両側大脳基底核病変を呈する代謝性脳症をきたした血液透析患者の一例
黒田彩加、石﨑友梨、西園隆三、菊池正雄、稲垣浩子、佐藤祐二、藤元昭一
第49回日本腎臓学会西部学術大会
Event date： 2019.10
Language：Japanese Presentation type：Poster presentation
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免疫チェックポイント阻害薬関連心筋炎との鑑別に苦慮したトロポニンＴ産生篩骨洞がんの一例
鶴田敏博、佐藤勇一郎、梶原啓、川畑隆之、久富木庸子、菊池正雄、石川哲憲、東野哲也、北村和雄
第2回日本腫瘍循環器学会学術集会
Event date： 2019.9.21 - 2019.9.22
Language：Japanese Presentation type：Poster presentation
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Ⅰ型糖尿病，微小変化型ネフローゼ症候群をほぼ同時期に発症し急性腎不全を呈した1例
櫛間菜津美、古郷博紀、石﨑友梨、新屋琴子、日髙竜太郎、崎原久美子、西園隆三、菊池正雄、佐藤祐二、藤元昭一
日本内科学会第326回九州地方会
Event date： 2019.8
Language：Japanese Presentation type：Poster presentation
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両側大脳基底核病変を呈する代謝性脳症をきたした血液透析患者の一例
石﨑友梨、西園隆三、菊池正雄、稲垣浩子、佐藤祐二、藤元昭一
第47回宮崎県人工透析研究会
Event date： 2019.7.27
Language：Japanese Presentation type：Poster presentation
Grant-in-Aid for Scientific Research 【 display / non-display 】
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新生児スクリーニングを契機に発見される家系内ファブリー病症例のコホート研究
Grant number：25K13371 2025.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Coinvestigator(s)
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循環器疾患の臓器障害におけるビッグアンジオテンシン-25の役割と生成機構の解明
Grant number：19K08543 2019.04 - 2022.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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循環器疾患の臓器障害におけるビッグアンジオテンシン-25の役割と生成機構の解明
Grant number：19K08543 2019.04 - 2022.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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循環器疾患の臓器障害におけるビッグアンジオテンシン-25の役割と生成機構の解明
Grant number：19K08543 2019.04 - 2022.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)