Affiliation |
Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Pediatrics |
Title |
Assistant Professor |
External Link |
TANAKA Etsuko
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Papers 【 display / non-display 】
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Tanigawa S, Tanaka E, Miike K, Ohmori T, Inoue D, Cai CL, Taguchi A, Kobayashi A, Nishinakamura R
Nature communications 13 ( 1 ) 611 2022.2
Authorship:Lead author Language:English Publishing type:Research paper (scientific journal) Publisher:Nature Communications
Organs consist of the parenchyma and stroma, the latter of which coordinates the generation of organotypic structures. Despite recent advances in organoid technology, induction of organ-specific stroma and recapitulation of complex organ configurations from pluripotent stem cells (PSCs) have remained challenging. By elucidating the in vivo molecular features of the renal stromal lineage at a single-cell resolution level, we herein establish an in vitro induction protocol for stromal progenitors (SPs) from mouse PSCs. When the induced SPs are assembled with two differentially induced parenchymal progenitors (nephron progenitors and ureteric buds), the completely PSC-derived organoids reproduce the complex kidney structure, with multiple types of stromal cells distributed along differentiating nephrons and branching ureteric buds. Thus, integration of PSC-derived lineage-specific stroma into parenchymal organoids will pave the way toward recapitulation of the organotypic architecture and functions.
MISC 【 display / non-display 】
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Tanigawa S., Tanaka E., Miike K., Ohmori T., Inoue D., Cai C.L., Taguchi A., Kobayashi A., Nishinakamura R.
Nature Communications 14 ( 1 ) 2023.12
Publishing type:Rapid communication, short report, research note, etc. (scientific journal) Publisher:Nature Communications
The original version of the Supplementary Information associatedwith this Article contained an error in the legend of Supplementary Fig. 1d, which stated ‘Tamoxifen was injected at E9.5 and the mice were analyzed at E15.5’. The correct version of the legend now states ‘Tamoxifen was injected at E11.5 and the mice were analyzed at E15.5’ The HTML has been updated to include a corrected version of the Supplementary Information.
Awards 【 display / non-display 】
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優秀演題奨励賞
2022.5 日本小児腎臓病学会 間質前駆細胞の誘導法開発に基づく多能性幹細胞からの腎臓高次構造の再構築
田中 悦子
Award type:Award from Japanese society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
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ヒトiPS細胞由来腎臓オルガノイドを用いたLMX1B変異に伴う腎症の病態解明
Grant number:22K16246 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 若手研究
Authorship:Principal investigator
Available Technology 【 display / non-display 】
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遺伝性腎疾患の病態モデルを作製し、機序解明と治療法開発をする
生体外で血流をもつ腎臓オルガノイドを作製する<共同研究>
誘導腎臓上皮細胞(ポドサイト)を用いて、ポドサイト障害の機序を検討するRelated fields where technical consultation is available:ヒトiPS細胞から腎臓オルガノイドの作製
Message:ヒトiPS細胞由来腎臓オルガノイドを用いた研究に興味のある方と、臨床に生かせるような共同研究ができたらいいなと思っています。よろしくお願いいたします。