TANAKA Etsuko

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Pediatrics

Title

Assistant Professor

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Degree 【 display / non-display

  • 医学博士 ( 2021.3   熊本大学 )

 

Papers 【 display / non-display

  • Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma. Reviewed

    Tanigawa S, Tanaka E, Miike K, Ohmori T, Inoue D, Cai CL, Taguchi A, Kobayashi A, Nishinakamura R

    Nature communications   13 ( 1 )   611   2022.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nature Communications  

    Organs consist of the parenchyma and stroma, the latter of which coordinates the generation of organotypic structures. Despite recent advances in organoid technology, induction of organ-specific stroma and recapitulation of complex organ configurations from pluripotent stem cells (PSCs) have remained challenging. By elucidating the in vivo molecular features of the renal stromal lineage at a single-cell resolution level, we herein establish an in vitro induction protocol for stromal progenitors (SPs) from mouse PSCs. When the induced SPs are assembled with two differentially induced parenchymal progenitors (nephron progenitors and ureteric buds), the completely PSC-derived organoids reproduce the complex kidney structure, with multiple types of stromal cells distributed along differentiating nephrons and branching ureteric buds. Thus, integration of PSC-derived lineage-specific stroma into parenchymal organoids will pave the way toward recapitulation of the organotypic architecture and functions.

    DOI: 10.1038/s41467-022-28226-7

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Awards 【 display / non-display

  • 優秀演題奨励賞

    2022.5   日本小児腎臓病学会   間質前駆細胞の誘導法開発に基づく多能性幹細胞からの腎臓高次構造の再構築

    田中 悦子

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    Award type:Award from Japanese society, conference, symposium, etc. 

Grant-in-Aid for Scientific Research 【 display / non-display

  • ヒトiPS細胞由来腎臓オルガノイドを用いたLMX1B変異に伴う腎症の病態解明

    Grant number:22K16246  2022.04 - 2025.03

    独立行政法人日本学術振興会  科学研究費補助金  若手研究

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    Authorship:Principal investigator 

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