|
Affiliation |
Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Pediatrics |
|
Title |
Assistant Professor |
|
External Link |
|
|
Related SDGs |
|
TANAKA Etsuko
|
|
|
Papers 【 display / non-display 】
-
Tanigawa S, Tanaka E, Miike K, Ohmori T, Inoue D, Cai CL, Taguchi A, Kobayashi A, Nishinakamura R
Nature communications 13 ( 1 ) 611 2022.2
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Nature Communications
Organs consist of the parenchyma and stroma, the latter of which coordinates the generation of organotypic structures. Despite recent advances in organoid technology, induction of organ-specific stroma and recapitulation of complex organ configurations from pluripotent stem cells (PSCs) have remained challenging. By elucidating the in vivo molecular features of the renal stromal lineage at a single-cell resolution level, we herein establish an in vitro induction protocol for stromal progenitors (SPs) from mouse PSCs. When the induced SPs are assembled with two differentially induced parenchymal progenitors (nephron progenitors and ureteric buds), the completely PSC-derived organoids reproduce the complex kidney structure, with multiple types of stromal cells distributed along differentiating nephrons and branching ureteric buds. Thus, integration of PSC-derived lineage-specific stroma into parenchymal organoids will pave the way toward recapitulation of the organotypic architecture and functions.
-
第1土曜特集 My Medicine(マイ･メディシン)--オルガノイド研究が拓く新しい医療のかたち 基礎研究の観点から マイ･メディシン実現に向けた中胚葉オルガノイド研究の最新動向
田中 悦子, 小林 明雄, 西中村 隆一
医学のあゆみ 276 ( 6 ) 562 - 568 2021.2
Publishing type：Research paper (scientific journal) Publisher：医歯薬出版
DOI： 10.32118/ayu27606562
MISC 【 display / non-display 】
-
Tanigawa S., Tanaka E., Miike K., Ohmori T., Inoue D., Cai C.L., Taguchi A., Kobayashi A., Nishinakamura R.
Nature Communications 14 ( 1 ) 2023.12
Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Nature Communications
The original version of the Supplementary Information associatedwith this Article contained an error in the legend of Supplementary Fig. 1d, which stated ‘Tamoxifen was injected at E9.5 and the mice were analyzed at E15.5’. The correct version of the legend now states ‘Tamoxifen was injected at E11.5 and the mice were analyzed at E15.5’ The HTML has been updated to include a corrected version of the Supplementary Information.
Presentations 【 display / non-display 】
-
In vitro reconstitution of higher order kidney structure solely from pluripotent stem cells by establishing stromal progenitor induction protocol Invited International coauthorship International conference
Etsuko Tanaka
The 18th Congress of Asian Society for Pediatric Research (ASPR) 2023.11.11
Event date： 2023.11.11 - 2023.11.12
Language：English Presentation type：Symposium, workshop panel (nominated)
Awards 【 display / non-display 】
-
森田賞
2023.6 日本小児腎臓病学会 Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma
田中悦子
Award type：Award from Japanese society, conference, symposium, etc.
-
優秀演題奨励賞
2023.6 日本小児腎臓病学会 NPHS1にp.Val822Metを伴い自然寛解を反復した小児ネフローゼ症候群
田中悦子
Award type：International academic award (Japan or overseas)
-
優秀演題奨励賞
2022.5 日本小児腎臓病学会 間質前駆細胞の誘導法開発に基づく多能性幹細胞からの腎臓高次構造の再構築
田中 悦子
Award type：Award from Japanese society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
-
オルガノイド血管化・灌流によるヒト腎糸球体構造・機能の生体外再現法の開発
Grant number：24K22384 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 挑戦的研究（萌芽）
Authorship：Coinvestigator(s)
-
ヒトiPS細胞由来腎臓オルガノイドを用いたLMX1B変異に伴う腎症の病態解明
Grant number：22K16246 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 若手研究
田中 悦子
Authorship：Principal investigator
Available Technology 【 display / non-display 】
-
遺伝性腎疾患の病態モデルを作製し、機序解明と治療法開発をする
生体外で血流をもつ腎臓オルガノイドを作製する＜共同研究＞
誘導腎臓上皮細胞（ポドサイト）を用いて、ポドサイト障害の機序を検討するRelated fields where technical consultation is available：ヒトiPS細胞から腎臓オルガノイドの作製
Message：ヒトiPS細胞由来腎臓オルガノイドを用いた研究に興味のある方と、臨床に生かせるような共同研究ができたらいいなと思っています。よろしくお願いいたします。