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医学部 医学科 発達泌尿生殖医学講座小児科学分野 |
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Tanigawa S, Tanaka E, Miike K, Ohmori T, Inoue D, Cai CL, Taguchi A, Kobayashi A, Nishinakamura R
Nature communications 13 ( 1 ) 611 2022年2月
担当区分:筆頭著者 記述言語:英語 掲載種別:研究論文(学術雑誌) 出版者・発行元:Nature Communications
Organs consist of the parenchyma and stroma, the latter of which coordinates the generation of organotypic structures. Despite recent advances in organoid technology, induction of organ-specific stroma and recapitulation of complex organ configurations from pluripotent stem cells (PSCs) have remained challenging. By elucidating the in vivo molecular features of the renal stromal lineage at a single-cell resolution level, we herein establish an in vitro induction protocol for stromal progenitors (SPs) from mouse PSCs. When the induced SPs are assembled with two differentially induced parenchymal progenitors (nephron progenitors and ureteric buds), the completely PSC-derived organoids reproduce the complex kidney structure, with multiple types of stromal cells distributed along differentiating nephrons and branching ureteric buds. Thus, integration of PSC-derived lineage-specific stroma into parenchymal organoids will pave the way toward recapitulation of the organotypic architecture and functions.
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Tanigawa S., Tanaka E., Miike K., Ohmori T., Inoue D., Cai C.L., Taguchi A., Kobayashi A., Nishinakamura R.
Nature Communications 14 ( 1 ) 2023年12月
掲載種別:速報,短報,研究ノート等(学術雑誌) 出版者・発行元:Nature Communications
The original version of the Supplementary Information associatedwith this Article contained an error in the legend of Supplementary Fig. 1d, which stated ‘Tamoxifen was injected at E9.5 and the mice were analyzed at E15.5’. The correct version of the legend now states ‘Tamoxifen was injected at E11.5 and the mice were analyzed at E15.5’ The HTML has been updated to include a corrected version of the Supplementary Information.
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優秀演題奨励賞
2022年5月 日本小児腎臓病学会 間質前駆細胞の誘導法開発に基づく多能性幹細胞からの腎臓高次構造の再構築
田中 悦子
受賞区分:国内学会・会議・シンポジウム等の賞
科研費(文科省・学振・厚労省)獲得実績 【 表示 / 非表示 】
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ヒトiPS細胞由来腎臓オルガノイドを用いたLMX1B変異に伴う腎症の病態解明
研究課題/領域番号:22K16246 2022年04月 - 2025年03月
独立行政法人日本学術振興会 科学研究費補助金 若手研究
担当区分:研究代表者