論文 - 菱川 善隆
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Kyaw MNH*, Yamaguchi Y* (equally contributed), Choijookhuu N, Yano K, Takagi H, Takahashi N, Oo PS, Sato K, Hishikawa Y
Acta Histochemica et Cytochemica 52 ( 1 ) 1 - 8 2019年3月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本組織細胞化学会
Hepatoid adenocarcinoma (HAC) is a rare and aggressive gastrointestinal tract cancer that is characterized by hepatic differentiation and production of alpha-fetoprotein (AFP). Cisplatin is mainly used to treat HAC, but the efficacy is poor. Recently, the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), was approved as an anticancer agent. In this study, we investigated the anticancer effect of SAHA in combination with cisplatin in VAT-39 cells, a newly established HAC cell line. Cell viability and apoptosis were examined by MTT assay, flow cytometry and TUNEL assay. Expression of H3S10, cleaved caspase-3, Bax, and Bcl-2 were evaluated by immunohistochemistry and western blotting. AFP levels were examined in VAT-39 cells and culture medium. Combined treatment with cisplatin and SAHA efficiently inhibited cell proliferation and decreased cell viability. Apoptotic cells, but not necrotic cells, were significantly increased following the combined treatment, and an increase in the Bax/Bcl-2 ratio indicated that the combination of cisplatin and SAHA induced apoptosis through the mitochondrial pathway. VAT-39 cells treated with cisplatin and SAHA also partially lost their main characteristic of AFP production. We conclude that cisplatin and SAHA have a synergistic anticancer effect of inducing apoptosis, and that this combination treatment may be effective for HAC.
DOI： 10.1267/ahc.18044
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Fukaya T., Fukui T., Uto T., Takagi H., Nasu J., Miyanaga N., Arimura K., Nakamura T., Koseki H., Choijookhuu N., Hishikawa Y., Sato K.
Frontiers in Immunology 9 ( JUN ) 1418 2018年6月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Frontiers in Immunology
© 2018 Fukaya, Fukui, Uto, Takagi, Nasu, Miyanaga, Arimura, Nakamura, Koseki, Choijookhuu, Hishikawa and Sato. Disruption of skin homeostasis can lead to inflammatory cutaneous diseases resulting from the dysregulated interplay between epithelial keratinocytes and immune cells. Interleukin (IL)-22 signaling through membrane-bound IL-22 receptor 1 (IL-22R1) is crucial to maintain cutaneous epithelial integrity, and its malfunction mediates deleterious skin inflammation. While IL-22 binding protein (IL-22BP) binds IL-22 to suppress IL-22 signaling, how IL-22BP controls epithelial functionality to prevent skin inflammation remains unclear. Here, we describe the pivotal role of IL-22BP in mediating epithelial autoregulation of IL-22 signaling for the control of cutaneous pathogenesis. Unlike prominent expression of IL-22BP in dendritic cells in lymphoid tissues, epidermal keratinocytes predominantly expressed IL-22BP in the skin in the steady state, whereas its expression decreased during the development of psoriatic inflammation. Deficiency in IL-22BP aggravates psoriasiform dermatitis, accompanied by abnormal hyperproliferation of keratinocytes and excessive cutaneous inflammation as well as enhanced dermal infiltration of granulocytes and γδT cells. Furthermore, IL-22BP abrogates the functional alternations of keratinocytes upon stimulation with IL-22. On the other hand, treatment with IL-22BP alleviates the severity of cutaneous pathology and inflammation in psoriatic mice. Thus, the fine-tuning of IL-22 signaling through autocrine IL-22BP production in keratinocytes is instrumental in the maintenance of skin homeostasis.
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Critical role of plasmacytoid dendritic cells in induction of oral tolerance. 査読あり
Uto T., Takagi H., Fukaya T., Nasu J., Fukui T., Miyanaga N., Arimura K., Nakamura T., Choijookhuu N., Hishikawa Y., Sato K.
Journal of Allergy and Clinical Immunology. 141 ( 6 ) 2156 - 2167 2018年6月
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HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles 査読あり
Lee D, Taniguchi N, Sato K, Choijookhuu N, Hishikawa Y, Kataoka H, Morinaga H, Lotz M, Chosa E
Scientific Reports 8 ( 1 ) 9601 2018年6月
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Estrogen Regulates Mitochondrial Morphology through Phosphorylation of Dynamin-related Protein 1 in MCF7 Human Breast Cancer Cells 査読あり
Oo PS, Yamaguchi Y, Sawaguchi A, Kyaw MNH, Choijookhuu N, Ali MN, Srisowanna N, Hino SI, Hishikawa Y
Acta Histochemica et Cytochemica 51 ( 1 ) 21 - 31 2018年3月
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The HDAC Inhibitor, SAHA, Prevents Colonic Inflammation by Suppressing Pro-inflammatory Cytokines and Chemokines in DSS-induced Colitis. 査読あり
Ali MN, Choijookhuu N, Takagi H, Srisowanna N, Nguyen Nhat Huynh M, Yamaguchi Y, Synn Oo P, Tin Htwe Kyaw M, Sato K, Yamaguchi R, Hishikawa Y
Acta Histochemica et Cytochemica 51 ( 1 ) 33 - 40 2018年3月
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Photodynamic therapy of human biliary cancer cell line using combination of phosphorus porphyrins and light emitting diode 査読あり
Matsumoto J., Suzuki K., Yasuda M., Yamaguchi Y., Hishikawa Y., Imamura N., Nanashima A.
Bioorganic & Medicinal Chemistry. 25 ( 24 ) 6536 - 6541 2017年12月
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Novel role of Rac-Mid1 signaling in medial cerebellar development 査読あり
Nakamura T, Ueyama T, Ninoyu Y, Sakaguchi H, Choijookhuu N, Hishikawa Y, Kiyonari H, Kohta M, Sakahara M, de Curtis I, Kohmura E, Hisa Y, Aiba A, Saito N
Development (Cambridge, England) 144 ( 10 ) 1863 - 1875 2017年5月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1242/dev.147900
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Flexible adaptation of male germ cells from female iPSCs of endangered Tokudaia osimensis. 査読あり
Honda A, Choijookhuu N, Izu H, Kawano Y, Inokuchi M, Honsho K, Lee AR, Nabekura H, Ohta H, Tsukiyama T, Ohinata Y, Kuroiwa A, Hishikawa Y, Saitou M, Jogahara T, Koshimoto C.
Science advances 3 ( 5 ) e1602179 2017年5月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Naïve Conversion. 査読あり
Honda A, Kawano Y, Izu H, Choijookhuu N, Honsho K, Nakamura T, Yabuta Y, Yamamoto T, Takashima Y, Hirose M, Sankai T, Hishikawa Y, Ogura A, Saitou M.
Sci Rep. 7 45285 2017年3月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1038/srep45285
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Estrogen accelerates cell proliferation through estrogen receptor alpha during rat liver regeneration after partial hepatectomy. 査読あり
Baatarsuren Batmunkh, Narantsog Choijookhuu, Naparee Srisowanna, Uugantsetseg Byambatsogt, Phyu Synn Oo, Mohmand Noor Ali, Yuya Yamaguchi, Yoshitaka Hishikawa
Acta Histochem. Cytochem 50 ( 1 ) 39 - 48 2017年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Frequency of CD4+CD161+ T cell and interleukin-10 expression in inflammatory bowel diseases. 査読あり
Kazuyo Tsuchiya, Takuto Ikeda, Baatarsuren Batmunkh, Narantsog Choijookhuu, Hidenobu Ishizaki, Masayuki Hotokezaka, Yoshitaka Hishikawa and Atsushi Nanashima
Acta Histochem. Cytochem 50 ( 1 ) 21 - 28 2017年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Arsenic trioxide induces ROS activity and DNA damage, leading to G0/G1 extension in skin fibroblasts through the ATM-ATR-associated Chk pathway. 査読あり
Jutapon Chayapong, Harishkumar Madhyastha,Radha Madhyastha,Queen Intan Nurrahmah,Yuichi Nakajima,Narantsog Choijookhuu,Yoshitaka Hishikawa,Masugi Maruyama
Environ Sci Pollut Res Int. 24 ( 6 ) 5316 - 5325 2017年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation Mucosal Immunol. 査読あり
K Arimura, H Takagi, T Uto, T Fukaya, T Nakamura, N Choijookhuu, Y Hishikawa, Y Yamashita and K Sato
Mucosal Immunol 10 ( 4 ) 957 - 970 2016年11月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1038/mi.2016.96
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Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation. 査読あり
Takagi H, Arimura K, Uto T, Fukaya T, Nakamura T, Choijookhuu N, Hishikawa Y, Sato K.
Scientific Reports 6 1 - 18 2016年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1038/srep24477
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The role of estrogen receptors in intestinal homeostasis and disease 査読あり
Choijookhuu N, Hino SI, Oo PS, Batmunkh B, Hishikawa Y
Receptors Clin Investig 3 ( 1 ) 2016年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.14800/rci.1109
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Hyperbaric Oxygen Therapy Suppresses Apoptosis and Promotes Renal Tubular Regeneration After Renal Ischemia/Reperfusion Injury in Rats. 査読あり
Heihachi Migita, Shigenori Yoshitake,Yoshihiro Tange,Narantsog Choijookhuu,andYoshitaka Hishikawa
Nephro-Urology Monthly (International Bimonthy Medical Journal) 8 ( 1 ) e34421 2016年1月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway. 査読あり
Yamaguchi Y, Madhyastha H, Madhyastha R, Choijookhuu N, Hishikawa Y, Pengjam Y, Nakajima Y, Maruyama M
J Toxicol Sci. 41 ( 1 ) 105 - 113 2016年1月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.2131/jts.41.105
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Transplanted fibroblast cell sheets promote migration of hepatic progenitor cells in the incised host liver in allogenic rat model. 査読あり
Muraoka I, Takatsuki M, Sakai Y, Tomonaga T, Soyama A, Hidaka M, Hishikawa Y, Koji T, Utoh R, Ohashi K, Okano T, Kanematsu T, Eguchi S
J Tissue Eng Regen Med 11 E108 - E115 2015年11月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1002/term.1718.
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Ontogenetic changes in the expression of estrogen receptor β in mouse duodenal epithelium.（共著） 査読あり
Choijookhuu N, Hino SI, Oo PS, Batmunkh B, Ali MN, Kyaw MTH, Hishikawa Y
Clinics and research in hepatology and gastroenterology 39 ( 4 ) 499 - 507 2015年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）