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Affiliation |
Faculty of Medicine College Hospital Department of Pathology |
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Title |
Assistant Professor |
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External Link |
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MORIGUCHI Sayaka
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Papers 【 display / non-display 】
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Prognostic analysis of smoldering ATLL with skin eruptions based on genomic aberrations. Reviewed
Mochida K, Nakahata S, Suzuki Y, Inoue K, Moriguchi S, Yamashita A, Amano M, Morishita K
Journal of dermatological science 2023.2
Language：English Publishing type：Research paper (scientific journal)
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Gi T., Kuwahara A., Yamashita A., Matsuda S., Maekawa K., Moriguchi-Goto S., Sato Y., Asada Y.
Arteriosclerosis, Thrombosis, and Vascular Biology 43 ( 1 ) 146 - 159 2023.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Arteriosclerosis, Thrombosis, and Vascular Biology
Background: Cancer-associated venous thromboembolism (VTE) is a critical complication in patients with cancer. However, the pathological findings of VTE are limited. Here, we investigated the histopathological features of cancer-associated VTE in human autopsy cases. Methods: We clinically examined the autopsy cases of VTE with (n=114) and without cancer (n=66) and immunohistochemically analyzed the expression of prothrombotic factors in intrathrombus cancer cells, the thrombus contents of erythrocytes, fibrin, platelets, citrullinated histone H3, and degree of organization. Results: Vascular wall invasion or small cell clusters of cancer cells was observed in thrombi in 27.5% of deep vein thrombosis and 25.9% of pulmonary embolism cases. The majority of the cancer cells in deep vein thrombi appeared to be invading the vessel wall, whereas the majority of pulmonary thrombi had cancer cell clusters, consistent with embolization via blood flow. These cancer cells were immunohistochemically positive for TF (tissue factors) or podoplanin in up to 88% of VTE cases. The frequency of TF-positive monocyte/macrophages in thrombi was higher in cancer-associated VTE than that in VTE without cancer. Citrullinated histone H3 was predominantly observed in the early stages of organizing thrombi. There was no significant difference in thrombus components between VTE with cancer and without cancer groups. Conclusions: Vascular wall invasion or cancer cell clusters in thrombi might influence thrombogenesis of cancer-associated VTE. TF and podoplanin in cancer cells and in monocyte/macrophages may induce coagulation reactions and platelet aggregation. Neutrophil extracellular traps may play a role in the early stages of VTE, regardless of cancer status.
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肺腫瘍塞栓症により呼吸不全を呈した子宮体部未分化癌の１剖検例 Reviewed
山本哲平，中村恵理子，盛口清香，山下篤，藤崎碧，大西淳仁，桂木真司，佐藤勇一郎
診断病理 2023
Publishing type：Case report
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Prognostic analysis of smoldering ATLL with skin eruptions based on genomic aberrations. Reviewed
2. Mochida K, Nakahata S, Suzuki Y, Inoue K, Moriguchi S, Yamashita A, Amano M, Morishita K.
J Dermatol Sci. 2023
Publishing type：Research paper (scientific journal)
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IgA 免疫組織化学的染色が診断に有用であった多中心性Castleman 病の1 例． Reviewed
1. 森愛菜，西元順子，後田優香，持田耕介，阿萬紫，盛口淸香，天野正宏
皮膚臨床 2023
Publishing type：Case report
MISC 【 display / non-display 】
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An autopsy case of elderly-onset acute necrotizing encephalopathy secondary to influenza.
Ishii N, Mochizuki H, Moriguchi-Goto S, Shintaku M, Asada Y, Taniguchi A, Shiomi K, Nakazato M.
Journal of neurological sciences 2015.7
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Elsevier.
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病理学の立場からみたDICの病態
盛口清香、丸塚浩助
血栓と循環 2015.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：メディカルレビュー社
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A case of myxoid smooth muscle tumor of the uterus.
Sayaka Moriguchi-Goto, Kazuko Fukushima, Hiroshi Samesima, Yujiro Asada, Yuichiro Sato
5 ( 2 ) 61 - 63 2014.5
Language：Japanese Publishing type：Research paper, summary (national, other academic conference)
Presentations 【 display / non-display 】
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真性癒着胎盤の臨床病理組織学的検討
佐藤勇一郎、盛口清香、山下 篤、浅田 祐士郎、鮫島 浩
第24回日本胎盤学会学術集会
Event date： 2016.11.25 - 2016.11.26
Language：Japanese Presentation type：Poster presentation
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神経内分泌細胞癌成分を伴った胃腺癌の1切除例
中尾大伸、河野文彰、田代耕盛、森浩貴、緒方祥吾、伊藤歌織、市成直樹、武野慎祐、池田拓人、七島篤志、中村都英、盛口淸香、佐藤勇一郎
第78回日本臨床外科学会総会
Event date： 2016.11.24 - 2016.11.26
Language：Japanese Presentation type：Poster presentation
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眼付属器に発生した低異型度B細胞性リンパ腫の4症例
野口裕史、徳満貴子、大野招伸、峰松映子、森田勝代、黒木栄輝、盛口清香、佐藤勇一郎
第56回日本臨床細胞学会
Event date： 2016.11.18 - 2016.11.19
Language：Japanese Presentation type：Poster presentation
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Atypical teratoid/rhabdoid tumorの2例
徳満貴子、野口裕史、大野招伸、峰松映子、森田勝代、黒木栄輝、福島剛、盛口清香、佐藤勇一郎
第55回日本臨床細胞学会
Event date： 2016.11.18 - 2016.11.19
Language：Japanese Presentation type：Poster presentation
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Pulmonary capillary hemangiomatosis (PCH) の一生検例
前川和也、佐藤勇一郎、鮫島直樹、山下篤、盛口清香、中村恵理子、魏峻洸、鬼塚、浅田祐士郎
第107回日本病理学会総会
Event date： 2016.5.12 - 2016.5.14
Language：English Presentation type：Poster presentation
Grant-in-Aid for Scientific Research 【 display / non-display 】
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重症熱性血小板減少症候群における血小板減少と血液凝固異常の病態解明
Grant number：23K06425 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator