MISC - NISHITOH Hideki
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褐色脂肪細胞の熱産生とエネルギー代謝
西頭英起
「臨床免疫・アレルギー科」科学評論社 2021.2
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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小胞体から発信されるストレスシグナルによるミトコンドリア制御 Invited
加藤裕紀, 西頭英起
「ミトコンドリアと疾患・老化」実験医学増刊 37 45 - 51 2019.7
Authorship：Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【タンパク質・核酸の分子修飾】細胞質/オルガネラでの分子修飾 タンパク質機能・品質管理 NEDD化
加藤 裕紀, 西頭 英起
生体の科学 69 ( 5 ) 460 - 461 2018.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：(公財)金原一郎記念医学医療振興財団
<文献概要>ユビキチン様タンパク質NEDD8による翻訳後修飾NEDD化は,標的タンパク質の安定化,活性化,局在化などに関与する.加えて,近年NEDD化修飾は,転写,細胞周期制御,クロマチン構成,ストレス顆粒形成などにも重要な役割を果たしている.本稿では,NEDD8修飾システムおよびその機能,がんとの関連性を概説する.
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成体ニューロン新生を介した記憶学習制御における小胞体品質管理機構の役割
村尾直哉, 西頭英起
Pharma Medica 35 ( 12 ) 93 - 93 2017.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：(株)メディカルレビュー社
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プロテオスタシス制御の新展開と疾患 ミトコンドリア-小胞体間のオルガネラ連携による細胞機能制御
西頭 英起
生命科学系学会合同年次大会 2017年度 [2AW19 - 5] 2017.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：生命科学系学会合同年次大会運営事務局
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褐色脂肪細胞のミトコンドリア機能制御における小胞体センサーPERKの新規役割
加藤裕紀, 西頭英起
日本生化学会大会(Web) 90th ROMBUNNO.1P‐0330 (WEB ONLY) - 0330] 2017.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：生命科学系学会合同年次大会運営事務局
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小胞体からはじまる多彩なシグナルと包括的生命機能制御 記憶学習における小胞体品質管理機構の役割
村尾 直哉, 西頭 英起
生命科学系学会合同年次大会 2017年度 [3PW17 - 4] 2017.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：生命科学系学会合同年次大会運営事務局
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門脇寿枝, 西頭英起
日本細胞生物学会大会(Web) 69th ROMBUNNO.T5‐05(P2‐017) (WEB ONLY) - 0143] 2017.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：生命科学系学会合同年次大会運営事務局
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中枢神経組織における小胞体品質機構の破綻に起因する運動障害のメカニズム
杉山崇史, 村尾直哉, 西頭英起
日本生化学会大会(Web) 90th ROMBUNNO.2P‐1209 (WEB ONLY) - 1209] 2017.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：生命科学系学会合同年次大会運営事務局
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加藤裕紀, 西頭英起
Pharma Medica 35 ( 11 ) 82 - 82 2017.11
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：(株)メディカルレビュー社
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褐色脂肪細胞における小胞体センサーPERKを介したミトコンドリア機能制御
加藤裕紀, 西頭英起
日本獣医学会学術集会講演要旨集 160th 267 2017.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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オルガネラから疾患を考える 褐色脂肪細胞における小胞体センサーPERKを介したミトコンドリア機能制御
加藤 裕紀, 西頭 英起
日本獣医学会学術集会講演要旨集 160回 267 - 267 2017.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：(公社)日本獣医学会
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門脇寿枝, 西頭英起
日本生化学会大会(Web) 90th ROMBUNNO.3P‐0143 (WEB ONLY) - 53 2017.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：(一社)日本細胞生物学会
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村尾直哉, 西頭英起
日本生化学会大会(Web) 90th ROMBUNNO.3PW17‐4 (WEB ONLY) 2017
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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成体ニューロン新生を介した記憶学習制御における小胞体品質管理機構の役割
村尾直哉, 西頭英起
臨床ストレス応答学会大会抄録集 12th 53 2017
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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Stress responses from the endoplasmic reticulum in cancer.
Kato H, Nishitoh H.
Frontiers in Oncology 5 93 - 93 2015.4
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Frontiers Media
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西頭 英起
上原記念生命科学財団研究報告集 28 1 - 4 2014
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：上原記念生命科学財団
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ALSにおける変異型SOD1に共通の構造変化を特異的に認識する新規モノクローナル抗体の作製
西頭 英起
第一三共生命科学研究振興財団研究報告集 30 149 - 162 2014
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：第一三共生命科学研究振興財団
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Signaling Pathways from the Endoplasmic Reticulum and their Role in Diseases.
Hisae Kadowaki, Hideki Nishitoh
Genes 4 ( 3 ) 306 - 333 2013.7
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：MDPI
DOI： 10.3390/genes4030306
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CHOP is a multifunctional transcription factor in the ER stress response
Hideki Nishitoh
The Journal of Biochemistry 151 ( 3 ) 217 - 219 2012.12
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：The Journal of Biochemistry
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The Role of Zinc and ER Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis
TSUBURAYA Naomi, HOMMA Kengo, NISHITOH Hideki, ICHIJO Hidenori
Biomedical research on trace elements 23 ( 1 ) 14 - 23 2012.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：日本微量元素学会
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西頭 英起
助成研究報告集 44 2012
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：病態代謝研究会
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西頭 英起
助成研究報告集 44 ( 0 ) 2012
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：病態代謝研究会
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The Role of Zinc and ER Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis
Tsuburaya Naomi, Homma Kengo, Nishitoh Hideki, Ichijo Hidenori
Biomedical Research on Trace Elements 23 ( 1 ) 14 - 23 2012
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Japan Society for Biomedical Research on Trace Elements
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the selective loss of upper and lower motoneurons. Approximately 10% of all ALS cases are genetically inherited, and a mutation in the Cu, Zn superoxide dismutase (SOD1) gene is thought to be a cause of motoneuron dysfunction. Importantly, the motoneuron toxicity appears to result from a toxic gain-of-function mutation in SOD1 and not from the loss of superoxide dismutase activity. Transgenic mice overexpressing several types of SOD1 mutant show the ALS-like phenotype and are widely accepted as animal models of ALS. However, no common toxic mechanism has been identified among these SOD1 mutants. Studies using autopsies of ALS patients or model mouse have suggested multiple causes of ALS including oxidative stress, mitochondrial dysfunction, excitotoxicity, neurofilaments abnormality and protein aggregation. Endoplasmic reticulum (ER) stress mediated motoneuron death is also suggested to be included in the pathogenesis of ALS. ALS-related mutant SOD1 evokes ER stress through the specific interaction with Derlin-1, a component of ER associated degradation (ERAD) machinery, leading to the subsequent motoneuron death. Zinc plays an important role in the function of nervous system and its dyshomeostasis is also thought to be one of the causes of ALS. In fact, zinc accumulation is observed in the brains and the spinal cords of mutant SOD1 transgenic mice. Moreover, zinc chelation extends the life span of these mise. There seems to be relationships between zinc dysregulation and several pathogenic processes of ALS. In this review, we will focus on the pathological role of ER stress and zinc in ALS.
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Apoptosis signaling kinases: from stress response to health outcomes（共著）
Kohsuke Takeda, Isao Naguro, Hideki Nishitoh, Atsushi Matsuzawa, Hidenori Ichijo
Antioxidants & Redox Signaling 15 ( 3 ) 719 - 761 2011.8
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Antioxidants & Redox Signaling
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西頭 英起
医科学応用研究財団研究報告 29 302 - 305 2010
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：鈴木謙三記念医科学応用研究財団
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[Molecular mechanisms of ALS-linked mutant SOD1-induced motor neuron death].
Nishitoh H, Ichijo H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54 ( 3 ) 237 - 244 2009.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：3
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[Molecular mechanisms of ER stress-induced apoptosis]
Nishitoh H, Ichijo H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 49 ( 7 Suppl ) 1006 - 1009 2004.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：7 Suppl
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小胞体ストレス誘導性アポトーシスの分子機構 (細胞における 蛋白質の一生--生成・成熟・輸送・管理・分解・病態) -- (蛋白質の品質管理)
西頭英起, 一條秀憲
蛋白質核酸酵素 49 ( 7 ) 1006 - 1009 2004.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：共立出版
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基礎 アポトーシスとシグナル伝達 (特集 シグナル伝達の基礎と臨床応用)
門脇寿枝, 一條秀憲, 西頭英起
現代医療 35 ( 12 ) 2835 - 2843 2003.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：現代医療社
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ASK1を介した小胞体ストレスによるJNK活性化ならびにアポトーシスの分子機構
西頭英起
歯科基礎医学会雑誌 45 ( 5 ) 2003.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：歯科基礎医学会
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公田有子, 西頭英起, 一條秀憲
歯科基礎医学会雑誌 44 ( 5 ) 2002.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：歯科基礎医学会
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マウスApoptosis Signal-regulating Kinase(ASK)2の遺伝子構造解析
邊見麻希, 飛梅圭, 畑井多喜子, 西頭英起, 武田弘資, 大山紀美栄, 一條秀憲
歯科基礎医学会雑誌 44 ( 5 ) 2002.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：歯科基礎医学会
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MAPキナーゼを介した小胞体ストレス誘導性アポトーシスのメカニズム (特集 小胞体ストレスとアポトーシス:オルガネラから発信される新たな死のシグナル)
西頭英起
細胞工学 21 ( 4 ) 377 - 381 2002.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：秀潤社
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Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
西頭 英起
Antioxid Redox Signal. 4(3):415-25. 2002
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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西頭英起, 一條秀憲
口腔病学会雑誌 68 ( 4 ) 2001.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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482 インフルエンザウイルス(IV)感染によるASK1/MAP kinase活性化機構の解析
丸岡秀一郎, 橋本修, 水村賢司, 権寧博, 浅井保清, 清水一史, 西頭英起, 一條秀憲, 堀江孝至
アレルギー 50 ( 9 ) 2001.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：日本アレルギー学会
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Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.
西頭 英起
Cancer Res. 61(14):5432-40. 2001
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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ストレスシグナルにおけるApoptosis Signal-Regulating Kinase(ASK)1の活性化機構の解明
西頭英起, 一條秀憲
歯科基礎医学会雑誌 42 ( 5 ) 2000.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：歯科基礎医学会
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ASK1-MAPキナーゼ系によるアポトーシスシグナルの制御機構
一條秀憲, 西頭英起, 武田弘資
歯科基礎医学会雑誌 42 ( 5 ) 2000.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：歯科基礎医学会
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ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.
西頭 英起
J Biol Chem. 275(13):9805-13. 2000
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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0909 Apoptosis signal-regulating kinase 1(ASK1)は心筋細胞にアポトーシスを誘導する
相川竜一, 小室一成, 山崎力, 矢崎義雄, 西頭英起, 一條秀憲
Japanese circulation journal 63 ( 1 ) 1999.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：社団法人日本循環器学会
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ストレスによる細胞死:ASK1-MAPK経路を介したシグナル伝達 (特集 アポト-シス実行のカスケ-ド--細胞死のシグナル伝達経路)
一條秀憲, 斉藤正夫, 西頭英起
細胞工学 17 ( 6 ) 914 - 921 1998.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：秀潤社
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ASKI is essential for JNK/SAPK activation by Traf 2
NISHITOH Hideki
Molecular Cell (Cell press) 2 ( 3 ) 389 1998
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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新規MAPKKK, ASK1によるアポトーシスシグナル伝達機構ならびにその硬組織形態形成における役割の解析
一條秀憲, 稲毛稔彦, 斉藤正夫, 西頭英起, 飛梅圭, 金本尚志, 丸岡豊, 澤田泰宏, 武田弘資, 宮園浩平
日本骨代謝学会雑誌 = Japanese journal of bone metabolism 15 ( 2 ) 1997.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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MAPキナ-ゼカスケ-ドと細胞死 (特集・最近のMAPキナ-ゼ系)
一条秀憲, 斉藤正夫, 西頭英起
生体の科学 48 ( 2 ) 124 - 129 1997.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：金原一郎記念医学医療振興財団
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骨形成因子(Bone Morphogenetic Proteins)受容体の同定
西頭英起
口腔病学会雑誌 64 ( 1 ) 24 - 37 1997.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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Growth/Differentiation Factor-5受容体の同定と機能解析
西頭英起, 一條秀憲, 宮園浩平, 牧島房夫, 木村道夫
日本分子生物学会年会プログラム・講演要旨集 19 1996.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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斉藤正夫, 西頭英起, 宮園浩平, 一條秀憲
日本骨代謝学会雑誌 = Japanese journal of bone metabolism 14 ( 2 ) 1996.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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Growth/Differentiation Factor-5 受容体の同定と機能解析
西頭英起, 一條秀憲, 宮園浩平, 牧島房夫, 木村道夫
日本骨代謝学会雑誌 = Japanese journal of bone metabolism 14 ( 2 ) 1996.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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森正次, 立川敬子, 小山治彦, 西頭英起, 三木貴司, 櫻井規雄, 織田光夫, 榎本昭二, 高橋浩一郎
日本骨代謝学会雑誌 = Japanese journal of bone metabolism 13 ( 2 ) 1995.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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西頭英起, 斉藤正夫, 宝田雅規, 瞿亦文, 朝比奈泉, 宮園浩平, 榎本昭二, 高木実, 一條秀憲
日本骨代謝学会雑誌 = Japanese journal of bone metabolism 13 ( 2 ) 1995.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)