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Faculty of Medicine School of Medicine Department of Medicine of Pathophysiological Diagnosis and Therapy, Emergency, Critical Care, and Disaster Medicine |
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OCHIAI Hidenobu
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Degree 【 display / non-display 】
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Ph.D (Medicine) ( 2005.3 University of Miyazaki )
Papers 【 display / non-display 】
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Novel Integration of Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy in Pediatric Patients With Severe Burns: A Case Report. Reviewed
Matsuoka H, Abe T, Yonaha T, Yano T, Taniguchi M, Nagano T, Tsuneyoshi I, Ochiai H
Cureus 18 ( 2 ) e102924 2026.2
Language：English Publishing type：Research paper (scientific journal)
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Koreeda H., Yoshikawa N., Sasaki A., Tasaki K., Itoh H., Ochiai H., Ikeda R.
European Journal of Hospital Pharmacy 2026
Language：English Publishing type：Research paper (scientific journal) Publisher：European Journal of Hospital Pharmacy
A 68-year-old male with severe burns was admitted for treatment. During the prolonged hospitalisation, discrepancies were observed between estimated glomerular filtration rate (eGFR) based on serum creatinine (eGFRcre) and actual renal function, as indicated by vancomycin therapeutic drug monitoring. Serum cystatin C measurement revealed a difference between eGFR based on serum cystatin C (eGFRcys) and eGFRcre. The patient experienced drug-induced liver injury, likely due to an inaccurate renal function assessment using serum creatinine. Adjusting drug doses based on eGFRcys improved clinical outcomes. Therefore, eGFRcre may overestimate renal function in patients with decreased muscle mass from prolonged hospitalisation and reduced physical activity. In emergency medicine, especially for patients with conditions affecting muscle mass, eGFRcys may be a more reliable marker for renal function evaluation than eGFRcre. Hence, alternative methods should be considered for assessing renal function in special populations to ensure appropriate drug dosing and prevent adverse effects.
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Sasaki A., Nakajima M., Shinozaki T., Sasabuchi Y., Ohbe H., Kaszynski R.H., Kimura Y., Morita K., Goto T., Aiyama Y., Nakayama I., Matsui H., Fushimi K., Ochiai H., Yasunaga H.
Journal of Intensive Care 13 ( 1 ) 57 2025.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Intensive Care
Background: In patients with pneumonia requiring mechanical ventilation, increased airway secretions are associated with prolonged mechanical ventilation, but the effect of mucoactive agents remains unclear. The present study aimed to investigate the association between early administration of mucoactive agents and in-hospital mortality in patients with pneumonia requiring mechanical ventilation. Methods: We conducted a retrospective cohort study using the Japanese Diagnosis Procedure Combination database, a nationwide inpatient database. Adult patients were eligible if they had a primary diagnosis of pneumonia and required invasive mechanical ventilation within 2 days of admission, with ventilation continued for ≥ 2 days between April 2012 and March 2023. Patients were divided into those who received at least one mucoactive agent within 2 days after the initiation of mechanical ventilation (mucoactive agent group) and those who did not (control group). Mucoactive agents included ambroxol (oral), bromhexine (oral, intravenous and nebulized), fudosteine (oral), carbocisteine (oral) and N-acetylcysteine (nebulized). We performed a propensity score overlap weighting analysis to compare in-hospital mortality. The number of ventilator-free days at 28 days was assessed as a secondary outcome. We also performed sensitivity analyses using inverse probability of treatment weighting, generalized estimating equations, and doubly robust methods. Results: Eligible patients (n = 10,942) were categorized into the mucoactive agent group (n = 2246) or control group (n = 8696). The most commonly prescribed mucoactive agent was carbocisteine (oral). After overlap weighting, in-hospital mortality was significantly lower in the mucoactive agent group than in the control group (25.2% vs. 27.5%; risk difference, − 2.3%; 95% confidence interval, − 4.4% to − 0.3%; p = 0.028). Ventilator-free days at 28 days did not significantly differ between the mucoactive agent group and the control group. Sensitivity analyses yielded similar results. Conclusions: In patients with ventilated pneumonia, early administration of mucoactive agents was associated with lower in-hospital mortality.
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投稿 症例 細菌性髄膜炎の経過中に低カリウム血症を契機にBrugada症候群様の心電図異常を呈し,心室細動をきたした1例 Reviewed
法化図 陽一, 中平 孝明, 日髙 颯之介, 北條 健人, 落合 秀信
内科 135 ( 6 ) 1397 - 1400 2025.6
Publishing type：Research paper (scientific journal) Publisher：南江堂
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What should acute care surgery be like in regional facilities? Reviewed
Kawano Fumiaki, Tashiro Kousei, Ikenoue Makoto, Munakata Shun, Suzuki Yasuto, Takeno Shinsuke, Furukawa Kouji, Ochiai Hidenobu, Nanashima Atsushi
Japanese Journal of Acute Care Surgery advpub ( 0 ) 97 - 100 2025.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for the Acute Care Surgery
We looked back on the 10 years of acute care surgery 〈ACS） at our department and discussed what type of ACS is required in facilities in regional cities. In our department, the emergency and critical care unit started in 2012, which required major changes in the surgical emergency treatment system. At the regional level, we focused on maintaining the existing emergency system, and we established a system in which severe injuries and trauma cases were concentrated in our department. At the facility level, ACS team was formed with existing surgeons to facilitate trauma care and actively intervene in trauma care. In addition, to maintain the team, we improved the on-call system and implemented complete division of labor in perioperative management. At the individual level, we performed daily surgical tasks with a specialty to maintain surgical skills and motivation. In addition, we made efforts to encourage young surgeons and residents to intervene in the practice in order to foster the Acute care surgeons. In this way, we believe that ACS in regional cities can be established by maintaining the existing emergency system and having existing surgeons create a system that is suited to the facilities.
DOI： 10.50840/jjacs.15-1
Books 【 display / non-display 】
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今日の治療指針2023年版 私はこう治療している
落合 秀信（ Role： Contributor , 【中毒性疾患】塩素ガス中毒）
医学書院 2023.1
Responsible for pages：143-143 Book type：Scholarly book
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今日の治療指針2022年版 私はこう治療している
落合 秀信（ Role： Contributor , 【中毒性疾患】シアン中毒）
医学書院 2022.1
Responsible for pages：143-143 Book type：Scholarly book
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今日の治療指針2021年版 私はこう治療している
落合 秀信（ Role： Contributor , 【中毒性疾患】酸・アルカリ化学損傷）
医学書院 2021.1
Responsible for pages：146-147 Book type：Scholarly book
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今日の治療指針2020年版 私はこう治療している
落合 秀信（ Role： Contributor , 【中毒性疾患】グリホサート・グルホシネート中毒）
医学書院 2020.1
Responsible for pages：134-135 Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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Azuma M., Nakada H., Takei M., Nakamura K., Katsuragawa S., Shinkawa N., Terada T., Masuda R., Hattori Y., Ide T., Kimura A., Shimomura M., Kawano M., Matsumura K., Meiri T., Ochiai H., Hirai T.
Emergency Radiology 29 ( 2 ) 425 2022.4
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Emergency Radiology
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Complement-mediated thrombotic microangiopathy secondary to sepsis-induced disseminated intravascular coagulation successfully treated with eculizumab: A case report.
Abe T, Sasaki A, Ueda T, Miyakawa Y, Ochiai H.
Wolters Kluwer Health 96 ( 6 ) e6056 2017.2
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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ノロウイルス性胃腸炎に合併した劇症型Clostridium perfringens感染症の1例 Reviewed
長野健彦, 安部智大, 長嶺育弘, 今井光一, 松岡博史, 金丸勝弘, 落合秀信, 牧原真治, 廣兼民徳
宮崎県医師会医学会誌 40 ( 1 ) 60 - 64 2016.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【E Word 私が大切にしている言葉】及ばざるは過ぎたるよりまされり 平常心
落合秀信
Emergency Care 26 ( 8 ) 1 - 1 2013.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：メディカ出版
Presentations 【 display / non-display 】
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地域医療機関と宮崎大学救命救急センターとの連携の過去・現在・未来について
落合秀信
第23回宮崎生協病院地域連携懇談会 (宮崎)
Event date： 2023.3.24
Presentation type：Oral presentation (invited, special)
Venue：宮崎
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宮崎大学における重度四肢外傷治療の実情と今後の課題
日吉優，帖佐悦男，中村嘉宏，今里浩之，平川雄介，山口洋一朗，森田雄大，落合秀信
第57回宮崎救急医学会 (宮崎)
Event date： 2023.3.18
Presentation type：Oral presentation (general)
Venue：宮崎
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宮崎県北部地域精神科救急疾患対応の現状と課題について
長嶺育弘，森久保裕，島津志帆子，岩本和樹，佐藤由佳子，出口ゆかり，木佐貫ゆかり，金丸勝弘，落合秀信
第57回宮崎救急医学会 (宮崎)
Event date： 2023.3.18
Presentation type：Oral presentation (general)
Venue：宮崎
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宮崎県北部地域救急医療体制の変化及び今後の課題について
長嶺育弘，森久保裕，島津志帆子，岩本和樹，木佐貫ゆかり，金丸勝弘，落合秀信
第57回宮崎救急医学会 (宮崎)
Event date： 2023.3.18
Presentation type：Oral presentation (general)
Venue：宮崎
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胃石形成により循環不全が遷延したアムロジピン中毒に対して上部消化管内視鏡を用いて洗浄・胃石除去を施行した1例
畠中健吾, 工藤陽平, 落合秀信
第6回日本臨床・分析中毒学会総会・学術集会 (川崎)
Event date： 2023.3.11
Presentation type：Oral presentation (general)
Venue：川崎