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Affiliation |
Faculty of Medicine College Hospital Mother and child health center of integrated perinatal period |
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NAKAME Kazuhiko
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Degree 【 display / non-display 】
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Doctor of philosophy in Medical Science ( 2017.3 Kagoshima University )
Papers 【 display / non-display 】
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Masuya R., Muraji T., Harumatsu T., Machigashira S., Iwamoto Y., Ogata M., Takada L., Nishida N., Kedoin C., Nagano A., Matsui M., Murakami M., Sugita K., Yano K., Onishi S., Yamada K., Yamada W., Matsukubo M., Kawano T., Muto M., Nakame K., Kaji T., Nanashima A., Ieiri S.
Surgery Today 54 ( 5 ) 452 - 458 2024.5
Language：English Publishing type：Research paper (scientific journal) Publisher：Surgery Today
Purpose: We compared the clinical features of patients with biliary atresia (BA) associated with a bleeding tendency (BT) at the time of the diagnosis with those of patients without a bleeding tendency (NBT). Methods: The patients’ background characteristics, age in days at the first visit, Kasai portoenterostomy (KPE), and postoperative course were retrospectively analyzed. Results: Nine of the 93 BA patients (9.7%) showed a BT, including 7 with intracranial hemorrhaging (ICH), 1 with gastrointestinal bleeding, and 1 with a prothrombin time (PT) of 0%. The age at the first visit was 62 ± 12 days old for BT patients and 53 ± 27 days old for NBT patients (p = 0.4); the age at KPE was 77 ± 9 days old for BT patients and 65 ± 24 days old for NBT patients (p = 0.2); the time from the first visit to surgery was 13 ± 7 days for BT patients and 11 ± 10 days for NBT patients (p = 0.5); and the native liver survival rate was 56% for BT patients and 58% for NBT patients (p = 1), with no significant difference in any of the parameters. The neurological outcomes of survivors of ICH were favorable. Conclusions: Appropriate BT correction allowed early KPE even after ICH, resulting in native liver survival rates comparable to those of NBT patients without significant neurological complications.
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特集 小児領域におけるGLP-2アナログ製剤(テデュグルチド)の応用 総論 GLP-2の基礎研究
矢野 圭輔, 杉田 光士郎, 武藤 充, 大西 峻, 岩元 祐実子, 緒方 将人, 高田 倫, 祁答院 千寛, 村上 雅一, 松久保 眞, 川野 孝文, 中目 和彦, 加治 建, 家入 里志
小児外科 56 ( 4 ) 320 - 325 2024.4
Publishing type：Research paper (scientific journal) Publisher：東京医学社
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Nakame Kazuhiko, Masuya Ryuta, Nakazawa Shun, Nakagawa Midori, Yamada Ai, Kinoshita Mariko, Kamimura Sachiyo, Moritake Hiroshi, Ieiri Satoshi, Nanashima Atushi
Journal of the Japanese Society of Pediatric Surgeons 60 ( 2 ) 158 - 165 2024.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Pediatric Surgeons
<i>Purpose</i>: Central venous catheters (CVCs) are used in the treatment of pediatric hematological and oncological diseases. Recently, the ultrasound (US)-guided supraclavicular approach to brachiocephalic vein cannulation with in-plane views has been described as a safe central venous catheterization technique.<i>Methods</i>: A retrospective study was performed on patients who underwent US-guided tunneled CVC insertion into the internal jugular vein with out-of-plane views (IJV group) and the brachiocephalic vein with in-plane views (BCV group). The patients’ background characteristics, surgical outcomes, and complications were compared retrospectively.<i>Results</i>: A total of 40 tunneled CVCs (IJV group: n = 15, BCV group: n = 25) were inserted in 34 patients. The patients’ background characteristics were not significantly different between the two groups. The operative times were 30 min (range: 27–33 min) in the IJV group and 25.8 min (range: 22–27 min) in the BCV group. The BCV group had a significantly shorter operative time (p = 0.0026). Intraoperative complications were observed in one patient (6.7%) in the IJV group and none of the patients in the BCV group. Complications during maintenance were observed in 10 patients (66.7%) in the IJV group and 17 patients (68%) in the BCV group. Catheter-related bloodstream infection was noted in 10 patients (66.7%) in the IJV group and 12 patients (52%) in the BCV group; these infection rates were not significantly different. The periods of CVC implantation were 273 days (172–363.5 days) in the IJV group and 152 days (101–280 days) in the BCV group, which were not significantly different.<i>Conclusions</i>: A real-time US-guided supraclavicular approach to brachiocephalic catheterization was considered a safe technique for pediatric patients with hematological and oncological diseases.
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Kedoin C., Muto M., Nagano A., Matsui M., Sugita K., Baba T., Miyoshi K., Masuya R., Murakami M., Yano K., Onishi S., Harumatsu T., Yamada W., Yamada K., Matsukubo M., Kawano T., Kuda M., Nakame K., Torikai M., Ieiri S.
Journal of Pediatric Surgery 59 ( 4 ) 566 - 570 2024.4
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Pediatric Surgery
Background: Most cases of intestinal malrotation appear in neonates with bilious vomiting due to midgut volvulus, whereas in cases that develop beyond infancy, the initial symptoms vary. This study investigated the clinical features of these two populations and identified issues that should be considered in daily practice. Methods: A retrospective chart review was conducted from January 1, 2010, to December 31, 2022. Data on patients with intestinal malrotation were collected in an anonymized fashion from five pediatric surgical hub facilities in the Southern Kyushu and Okinawa areas of Japan. Results: Of the 80 subjects, 57 (71.3%) were neonates (Group N) and 23 (28.7%) were infants and schoolchildren (Group I). The frequencies of initial symptoms, such as abdominal distention (Group N: 19.3% vs. Group I: 13.0%), bilious vomiting (59.6% vs. 43.5%), and hematochezia (8.8% vs. 21.7%), were not skewed by the age of onset (p = 0.535, 0.087, and 0.141, respectively). Midgut volvulus was significantly more frequent in Group N (71.9% [41/57] vs. 34.8% [8/23]; p = 0.005), while the degree of torsion was greater in group I (median 360° [interquartile range: 180–360°] vs. 450° [360–540°]; p = 0.029). Although the bowel resection rate was equivalent (7.0% [4/57] vs. 4.3% [1/23]; p = 1.000), half of the patients in Group N presented with 180° torsion. The neonatal intestine has been highlighted as being more susceptible to ischemia than that in older children. Conclusions: The incidence of midgut volvulus is higher in neonates than in older children. Even relatively mild torsion can cause ischemic bowel changes during the neonatal period. Level of Evidence: LEVEL III.
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特集 胆道閉鎖症の研究update 患児末梢血中の母親由来キメラ細胞の検出とその臨床的意義
桝屋 隆太, 連 利博, Sami B.Kanaan, 春松 敏夫, 武藤 充, 東間 未来, 矢内 俊裕, Anne M Stevens, J Lee Nelson, 中目 和彦, 七島 篤志, 家入 里志
小児外科 56 ( 2 ) 117 - 121 2024.2
Publishing type：Research paper (scientific journal) Publisher：東京医学社
MISC 【 display / non-display 】
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胃穿孔による汎発性腹膜炎を生じた急性胃軸捻転の1小児例
桝屋 隆太, 中目 和彦, 西牟田 雅人, 長友 謙三, 和田 敬, 甲斐 健吾, 池ノ上 実, 田代 耕盛, 市原 明子, 河野 文彰, 池田 拓人, 武野 慎祐, 七島 篤志
日本腹部救急医学会雑誌 40 ( 2 ) 313 - 313 2020.2
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本腹部救急医学会
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鹿児島県内の後天性声門下腔狭窄症例発生状況と患者背景からの考察
武藤 充, 連 利博, 永井 太一郎, 大西 峻, 春松 敏夫, 山田 耕嗣, 松久保 眞, 町頭 成郎, 中目 和彦, 向井 基, 加治 建, 家入 里志
日本小児外科学会雑誌 56 ( 1 ) 132 - 132 2020.2
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本小児外科学会
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声門下嚢胞による反復性クループ様症状を呈した1幼児例
永井 太一朗, 連 利博, 大西 峻, 武藤 充, 中目 和彦, 家入 里志
日本小児科学会雑誌 124 ( 1 ) 91 - 91 2020.1
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(公社)日本小児科学会
Presentations 【 display / non-display 】
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呼吸管理に難渋した先天性気管狭窄を合併した 超低出生体重児の一例
中目 和彦,當瀬 ちひろ,桝屋 隆太,村岡 純輔,山田 直史, 青木良則,牧 洋平,牧 愛美 ,山内 綾 , 山下 理絵,金子政時 ,児玉 由紀,桂木 真司 ,七島 篤志森田 圭一,畠山 理
第58回日本周産期・新生児医学会学術集会 2022.7.12
Event date： 2022.7.10 - 2022.7.12
Language：Japanese Presentation type：Oral presentation (general)
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臍帯ヘルニアから見えた腹壁破裂の遷延性貧血 国内5施設の後方視的観察研究
杉田 光士郎, 武藤 充, 大城 清哲, 久田 正昭, 金城 僚, 桝屋 隆太, 町頭 成郎, 川野 孝文, 中目 和彦, 鳥飼 源史, 茨 聡, 加治 建, 家入 里志
第59回日本小児外科学会学術集会 2022.5.21
Event date： 2022.5.19 - 2022.5.21
Language：Japanese Presentation type：Oral presentation (general)
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地域医療を支える小児外科医の働き方改革はどうあるべきか? 宮崎県の場合
永田 公二, 林田 真, 三好 きな, 谷口 直之, 桝屋 隆太, 中目 和彦, 七島 篤志, 家入 里志, 田尻 達郎
第59回日本小児外科学会学術集会 2022.5.20
Event date： 2022.5.19 - 2022.5.21
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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新生児消化管穿孔と動脈管開存の関連性に関する検討 過去10年間の経験症例をもとに
武藤 充, 生駒 真一郎, 村上 雅一, 川野 正人, 杉田 光士郎, 山田 和歌, 桝屋 隆太, 松久保 眞, 川野 孝文, 町頭 成郎, 坂本 浩一, 中目 和彦, 新山 新, 鳥飼 源史, 池江 隆正, 野口 啓幸, 茨 聡, 家入 里志
第59回日本小児外科学会学術集会 2022.5.20
Event date： 2022.5.19 - 2022.5.21
Language：Japanese Presentation type：Oral presentation (general)
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術前に判明した右肝動脈の破格を伴う先天性胆道拡張症に対する腹腔鏡手術の工夫
桝屋 隆太, 中目 和彦, 三好 きな, 松久保 眞, 七島 篤志, 家入 里志
第59回日本小児外科学会学術集会 2022.5.21
Event date： 2022.5.19 - 2022.5.21
Language：Japanese Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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GVHD誘導マウスでのサイトカイン阻害による胆道閉鎖症の炎症標的型治療法の開発
Grant number：23K08052 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究（C）
桝屋 隆太
Authorship：Coinvestigator(s)
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新生児壊死性腸炎の死亡0を目指した核酸医薬RAGEアプタマーによる革新的治療法の開発
Grant number：23K07281 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究（C）
Authorship：Coinvestigator(s)