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Affiliation |
Faculty of Medicine College Hospital Mother and child health center of integrated perinatal period |
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NAKAME Kazuhiko
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Degree 【 display / non-display 】
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Doctor of philosophy in Medical Science ( 2017.3 Kagoshima University )
Papers 【 display / non-display 】
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Physical growth and social prognosis of esophageal atresia after 15 years of age
Masuya R., Muto M., Sugita K., Murakami M., Yano K., Harumatsu T., Onishi S., Yamada K., Yamada W., Matsukubo M., Kawano T., Machigashira S., Nakame K., Torikai M., Mukai M., Kaji T., Ieiri S.
Annals of Pediatric Surgery 18 ( 1 ) 2022.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Pediatric Surgery
Background: The mortality rate of esophageal atresia (EA) has significantly improved, but late complications remain problematic. We evaluated the physical growth, late complications, and social prognosis of postoperative patients with EA who have reached 15 years of age. Methods: EA patients who were treated at our institution from 1984 to 2003 were enrolled. The follow-up, physical growth at the last visit, late complications and treatment, academic status, and employment situation were evaluated. Results: Twenty-nine EA patients were registered, and the 23 surviving patients (79.3%) were followed. Anthropometry at the latest visit tended to be below the standard values. Fundoplication was performed in 6 (26.1%) of 9 (39.1%) patients with gastroesophageal reflux. Anastomotic stenosis was found in 12 patients (52.2%), and 2 (8.7%) were treated with re-anastomosis. Thirteen patients were attending a regular school, and one was attending a school for disabled children. Four had jobs from 18 years of age. Follow-up was aborted during early childhood in nine patients. Conclusions: The physical size of EA was smaller than in the healthy population of the same age. Late complications had not affected the physical growth but were sometimes recognized in adolescence. The social prognosis of the patients was largely favorable.
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Laparoscopic dome resection for pediatric nonparasitic huge splenic cyst safely performed using indocyanine green fluorescence and percutaneous needle grasper.
Masuya R, Nakame K, Tahira K, Kai K, Hamada T, Yano K, Imamura N, Hiyoshi M, Nanashima A, Ieiri S
Asian journal of endoscopic surgery 15 ( 3 ) 693 - 696 2022.7
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The evaluation of eye gaze using an eye tracking system in simulation training of real-time ultrasound-guided venipuncture. International journal
Kaji Tatsuru, Yano Keisuke, Onishi Shun, Matsui Mayu, Nagano Ayaka, Murakami Masakazu, Sugita Koshiro, Harumatsu Toshio, Yamada Koji, Yamada Waka, Matsukubo Makoto, Muto Mitsuru, Nakame Kazuhiko, Ieiri Satoshi
The journal of vascular access 23 ( 3 ) 360 - 364 2022.5
Language：English Publishing type：Research paper (scientific journal)
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Impact of the Number of Board-Certified Pediatric Surgeons per Pediatric Population on the Outcomes of Laparoscopic Fundoplication for Neurologically Impaired Patients. International journal
Ryuta Masuya, Mitsuru Muto, Kazuhiko Nakame, Masakazu Murakami, Koshiro Sugita, Keisuke Yano, Shun Onishi, Toshio Harumatsu, Koji Yamada, Waka Yamada, Makoto Matsukubo, Tatsuru Kaji, Atsushi Nanashima, Satoshi Ieiri
Journal of laparoendoscopic & advanced surgical techniques. Part A 32 ( 5 ) 571 - 575 2022.5
Language：Japanese Publishing type：Research paper (scientific journal)
Background and Aim: The distribution of board-certified pediatric surgeons (BCPSs) in Japan is highly biased. While Prefecture M has one of the smallest numbers of BCPSs per pediatric population, neighboring Prefecture K has one of the largest numbers of BCPSs per pediatric population. We examined the effect of BCPSs population on laparoscopic surgery and postoperative management and outcomes. Materials and Methods: We compared postoperative duration to full-dose enteral nutrition, postoperative hospital stay, and complications of neurologically impaired patients who underwent laparoscopic fundoplication in two prefectures from 2006 to 2019. Results: Laparoscopic fundoplication was performed in 17 patients in Prefecture M and 63 in K. The mean operative time was 248.8 ± 79.9 minutes in Prefecture M and 260.8 ± 94.8 in K (P = .64). The median number of days to full-dose enteral nutrition was 11.5 in Prefecture M and 10 in K (P = .29). The median postoperative hospital stay was 14 days in Prefecture M and 15 days in K (P = .38). Postoperative complications occurred in 7 cases in Prefecture M and in 10 in K. The incidence was significantly higher in Prefecture M than in K (P = .041). Conclusion: Areas with insufficient numbers of BCPSs have a higher risk of complications in laparoscopic surgery than areas with sufficient numbers.
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Biliary atresia: Graft-versus-host disease with maternal microchimerism as an etiopathogenesis. International journal
Ryuta Masuya, Toshihiro Muraji, Toshio Harumatsu, Mitsuru Muto, Kazuhiko Nakame, Atsushi Nanashima, Satoshi Ieiri
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 61 ( 2 ) 103410 - 103410 2022.4
Language：Japanese Publishing type：Research paper (scientific journal)
Biliary atresia (BA) is an inflammatory disease of the biliary system in newborns and infants. The etiology is largely unknown. Approximately half of BA patients require liver transplantation by 20 years of age, even after surgical correction due to progressive fibrosis of the liver. Regarding the disease mechanism, there is circumstantial evidence to support the hypothesis of graft-versus-host disease because of the existence of maternal cells in the liver (maternal microchimerism, MMC), histopathological similarity of the liver and an intense maternal response to the BA patient with mixed lymphocyte culture. Immune dysregulation with decreased Treg and increased Th1 and Th17 cells are the pathogenic features of BA, which are homologous to the pathogenic features of GvHD. Further elucidation of the etiopathogenetic mechanism of BA is warranted for development of new therapeutic strategies for native liver survival.
MISC 【 display / non-display 】
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胃穿孔による汎発性腹膜炎を生じた急性胃軸捻転の1小児例
桝屋 隆太, 中目 和彦, 西牟田 雅人, 長友 謙三, 和田 敬, 甲斐 健吾, 池ノ上 実, 田代 耕盛, 市原 明子, 河野 文彰, 池田 拓人, 武野 慎祐, 七島 篤志
日本腹部救急医学会雑誌 40 ( 2 ) 313 - 313 2020.2
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本腹部救急医学会
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鹿児島県内の後天性声門下腔狭窄症例発生状況と患者背景からの考察
武藤 充, 連 利博, 永井 太一郎, 大西 峻, 春松 敏夫, 山田 耕嗣, 松久保 眞, 町頭 成郎, 中目 和彦, 向井 基, 加治 建, 家入 里志
日本小児外科学会雑誌 56 ( 1 ) 132 - 132 2020.2
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本小児外科学会
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声門下嚢胞による反復性クループ様症状を呈した1幼児例
永井 太一朗, 連 利博, 大西 峻, 武藤 充, 中目 和彦, 家入 里志
日本小児科学会雑誌 124 ( 1 ) 91 - 91 2020.1
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(公社)日本小児科学会
Presentations 【 display / non-display 】
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呼吸管理に難渋した先天性気管狭窄を合併した 超低出生体重児の一例
中目 和彦,當瀬 ちひろ,桝屋 隆太,村岡 純輔,山田 直史, 青木良則,牧 洋平,牧 愛美 ,山内 綾 , 山下 理絵,金子政時 ,児玉 由紀,桂木 真司 ,七島 篤志森田 圭一,畠山 理
第58回日本周産期・新生児医学会学術集会 2022.7.12
Event date： 2022.7.10 - 2022.7.12
Language：Japanese Presentation type：Oral presentation (general)
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臍帯ヘルニアから見えた腹壁破裂の遷延性貧血 国内5施設の後方視的観察研究
杉田 光士郎, 武藤 充, 大城 清哲, 久田 正昭, 金城 僚, 桝屋 隆太, 町頭 成郎, 川野 孝文, 中目 和彦, 鳥飼 源史, 茨 聡, 加治 建, 家入 里志
第59回日本小児外科学会学術集会 2022.5.21
Event date： 2022.5.19 - 2022.5.21
Language：Japanese Presentation type：Oral presentation (general)
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地域医療を支える小児外科医の働き方改革はどうあるべきか? 宮崎県の場合
永田 公二, 林田 真, 三好 きな, 谷口 直之, 桝屋 隆太, 中目 和彦, 七島 篤志, 家入 里志, 田尻 達郎
第59回日本小児外科学会学術集会 2022.5.20
Event date： 2022.5.19 - 2022.5.21
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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新生児消化管穿孔と動脈管開存の関連性に関する検討 過去10年間の経験症例をもとに
武藤 充, 生駒 真一郎, 村上 雅一, 川野 正人, 杉田 光士郎, 山田 和歌, 桝屋 隆太, 松久保 眞, 川野 孝文, 町頭 成郎, 坂本 浩一, 中目 和彦, 新山 新, 鳥飼 源史, 池江 隆正, 野口 啓幸, 茨 聡, 家入 里志
第59回日本小児外科学会学術集会 2022.5.20
Event date： 2022.5.19 - 2022.5.21
Language：Japanese Presentation type：Oral presentation (general)
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術前に判明した右肝動脈の破格を伴う先天性胆道拡張症に対する腹腔鏡手術の工夫
桝屋 隆太, 中目 和彦, 三好 きな, 松久保 眞, 七島 篤志, 家入 里志
第59回日本小児外科学会学術集会 2022.5.21
Event date： 2022.5.19 - 2022.5.21
Language：Japanese Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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GVHD誘導マウスでのサイトカイン阻害による胆道閉鎖症の炎症標的型治療法の開発
Grant number：23K08052 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究（C）
桝屋 隆太
Authorship：Coinvestigator(s)
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新生児壊死性腸炎の死亡0を目指した核酸医薬RAGEアプタマーによる革新的治療法の開発
Grant number：23K07281 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究（C）
Authorship：Coinvestigator(s)