TAKEYA Ryu

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Medical Sciences, Pharmacology

Title

Professor

External Link

Degree 【 display / non-display

  • 博士(医学) ( 2000.3   九州大学 )

Research Areas 【 display / non-display

  • Life Science / Pharmacology

  • Life Science / Pathological biochemistry

  • Life Science / Medical biochemistry

  • Life Science / Cell biology

  • Life Science / Cardiovascular surgery

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Papers 【 display / non-display

  • Extracellular signal-regulated kinase phosphorylation enhancement and Na<sub>V</sub>1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic pain: The efficacy and mechanism of pulsed radiofrequency therapy.

    Hidaka K, Maruta T, Koshida T, Kurogi M, Kage Y, Kouroki S, Shirasaka T, Takeya R, Tsuneyoshi I

    Molecular pain   18   17448069221089784   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/17448069221089784

    PubMed

  • Nursing pharmacology education and active-learning. Reviewed

    Yanagita Toshihiko, Kanaoka Maki, Kinoshita Yumiko, Takeya Ryu

    Folia Pharmacologica Japonica   157 ( 2 )   104 - 109   2022

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Pharmacological Society  

    <p>Comprehensive pharmacology education in nursing based on the "Patient-oriented Pharmacology" is effective against the improvement of quality of pharmacotherapy and patient satisfaction. Two active learning programs of practical pharmacotherapy for nursing students have been performed in School of Nursing, University of Miyazaki; (1) pharmacotherapy role-play for interprofessional education (IPE) and (2) practical excise for Kampo medicine. Pharmacotherapy role-play for IPE was performed as joint lecture both medical students and nursing students. This pharmacotherapy role-play is named Case & Communication based approach (C&C approach), since it is studied through communication between physicians, nurses and patients based on cases presented beforehand. In the practical excise for Kampo medicine, nursing students studied Kampo medicines and tried to taste 9 frequently used Kampo medicines. These active-learning programs in nursing pharmacology education may be effective for better understanding of pharmacotherapy and patient's feeling, and improvement of students' motivation as a nurse.</p>

    DOI: 10.1254/fpj.21100

    Scopus

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    CiNii Research

  • Differential effects of the formin inhibitor SMIFH2 on contractility and Ca2+ handling in frog and mouse cardiomyocytes Reviewed International journal

    Koji Sakata, Sho Matsuyama, Nagomi Kurebayashi, Kengo Hayamizu, Takashi Murayama, Kunihide Nakamura, Kazuo Kitamura, Sachio Morimoto, Ryu Takeya

    Genes to Cells   26 ( 8 )   583 - 595   2021.8

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    Genetic mutations in actin regulators have been emerging as a cause of cardiomyopathy, although the functional link between actin dynamics and cardiac contraction remains largely unknown. To obtain insight into this issue, we examined the effects of pharmacological inhibition of formins, a major class of actin-assembling proteins. The formin inhibitor SMIFH2 significantly enhanced the cardiac contractility of isolated frog hearts, thereby augmenting cardiac performance. SMIFH2 treatment had no significant effects on the Ca2+ sensitivity of frog muscle fibers. Instead, it unexpectedly increased Ca2+ concentrations of isolated frog cardiomyocytes, suggesting that the inotropic effect is due to enhanced Ca2+ transients. In contrast to frog hearts, the contractility of mouse cardiomyocytes was attenuated by SMIFH2 treatment with decreasing Ca2+ transients. Thus, SMIFH2 has opposing effects on the Ca2+ transient and contractility between frog and mouse cardiomyocytes. We further found that SMIFH2 suppressed Ca2+ -release via type 2 ryanodine receptor (RyR2); this inhibitory effect may explain the species differences, since RyR2 is critical for Ca2+ transients in mouse myocardium but absent in frog myocardium. Although the mechanisms underlying the enhancement of Ca2+ transients in frog cardiomyocytes remain unclear, SMIFH2 differentially affects the cardiac contraction of amphibian and mammalian by differentially modulating their Ca2+ handling.

    DOI: 10.1111/gtc.12873

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  • Fhod3 controls the dendritic spine morphology of specific subpopulations of pyramidal neurons in the mouse cerebral cortex Reviewed

    Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, and Ryu Takeya

    Cerebral Cortex   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/cercor/bhaa355

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  • Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain. Reviewed

    Toyoaki Maruta, Takayuki Nemoto, Koutaro Hidaka, Tomohiro Koshida, Tetsuro Shirasaka, Toshihiko Yanagita, Ryu Takeya Isao Tsuneyoshi

    PLoS ONE   14 ( 11 )   e0225586   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PLoS ONE  

    © 2019 Maruta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Oxaliplatin is the first-line chemotherapy for metastatic colorectal cancer. Unlike other platinum anticancer agents, oxaliplatin does not result in significant renal impairment and ototoxicity. Oxaliplatin, however, has been associated with acute and chronic peripheral neuropathies. Despite the awareness of these side-effects, the underlying mechanisms are yet to be clearly established. Therefore, in this study, we aimed to understand the factors involved in the generation of chronic neuropathy elicited by oxaliplatin treatment. We established a rat model of oxaliplatin-induced neuropathic pain (4 mg kg-1 intraperitoneally). The paw withdrawal thresholds were assessed at different time-points after the treatment, and a significant decrease was observed 3 and 4 weeks after oxaliplatin treatment as compared to the vehicle treatment (4.4 ± 1.0 vs. 16.0 ± 4.1 g; P < 0.05 and 4.4 ± 0.7 vs. 14.8 ± 3.1 g; P < 0.05, respectively). We further evaluated the role of different mitogen-activated protein kinases (MAPKs) pathways in the pathophysiology of neuropathic pain. Although the levels of total extracellular signal-regulated kinase (ERK) 1/2 in the dorsal root ganglia (DRG) were not different between oxaliplatin and vehicle treatment groups, phosphorylated ERK (pERK) 1/2 was up-regulated up to 4.5-fold in the oxaliplatin group. Administration of ERK inhibitor PD98059 (6 μg day-1 intrathecally) inhibited oxaliplatin-induced ERK phosphorylation and neuropathic pain. Therefore, upregulation of p-ERK by oxaliplatin in rat DRG and inhibition of mechanical allodynia by an ERK inhibitor in the present study may provide a better understanding of intracellular molecular alterations associated with oxaliplatin-induced neuropathic pain and help in the development of potential therapeutics.

    DOI: 10.1371/journal.pone.0225586

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    PubMed

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Books 【 display / non-display

  • ラング・デール薬理学 第8版

    H. P. Rang, J. M. Ritter, R. J. Flower, G. Henderson, 監訳 渡邊直樹( Role: Joint translator)

    エルゼビア・ジャパン  2018.12 

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    Language:Japanese Book type:Textbook, survey, introduction

  • ラング・デール薬理学 第8版

    H. P. Rang, J. M. Ritter, R. J.Flower, G. Henderson監訳 渡邊直樹( Role: Joint translator)

    エルゼビア・ジャパン  2018.12 

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    Language:Japanese Book type:Textbook, survey, introduction

  • マッキー生化学 第6版

    Trudy McKee ,James R.McKee, 監修 市川 厚, 監訳 福岡 伸一( Role: Joint translator ,  第18章 遺伝情報)

    化学同人  2018.3 

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    Language:Japanese Book type:Textbook, survey, introduction

  • マッキー生化学 第4版

    市川 厚, 福岡 伸一 他( Role: Joint translator ,  18章 遺伝情報)

    化学同人  2010.3 

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    Language:Japanese Book type:Textbook, survey, introduction

  • マッキー生化学 第3版

    市川 厚,福岡 伸一 他( Role: Joint translator ,  18章 遺伝情報)

    化学同人  2003.10 

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    Language:Japanese Book type:Textbook, survey, introduction

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MISC 【 display / non-display

  • 心筋サルコメアの形成とその維持機構

    武谷 立

    宮崎県医師会医学会誌 (別冊)   40 ( 1 )   1 - 6   2016.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)   Publisher:宮崎県医師会  

  • 心筋の収縮装置「サルコメア」の形成の分子機構

    武谷 立

    生存科学   26 ( 1 )   299 - 305   2015.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)   Publisher:公益財団法人 生存科学研究所  

  • 薬理学ロールプレイ:Case & Communication based approach によるアクティブラーニング

    柳田俊彦,根本隆行,武谷 立

    日本薬理学会雑誌   146 ( 2 )   115 - 118   2015.8

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)   Publisher:公益社団法人 日本薬理学会  

  • Regulation of superoxide-producing NADPH oxidases in nonphagocytic cells. Reviewed

    Takeya R, Ueno N, Sumimoto H

    Methods Enzymol.   2006

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 食細胞による微生物の取り込みと殺菌

    水上 令子,武谷 立,住本 英樹

    蛋白質核酸酵素   2006

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations 【 display / non-display

  • アクチン核化重合因子Fhod1の肺胞マクロファージにおける役割

    ○三浦綾子,實松史幸,武谷 立

    第95回日本薬理学会 

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    Event date: 2022.3.7 - 2022.3.9

    Language:Japanese   Presentation type:Poster presentation  

  • 神経細胞の形態制御におけるフォルミン蛋白質Fhod3の役割

    Hikmawan Wahyu Sulistomo, 根本隆行, 鹿毛陽子,  ○武谷立

    生体運動研究合同班会議2022 

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    Event date: 2022.1.7 - 2022.1.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  • フォルミン蛋白質Fhod3の心筋症病因変異がもたらす機能変化

    ○坂田鋼治, 鹿毛陽子, 武谷立

    生体運動研究合同班会議2022 

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    Event date: 2022.1.7 - 2022.1.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  • フォルミン阻害剤SMI-FH2による心機能の変容とその分子機序

    ○坂田鋼治, 松山翔, 呉林なごみ, 村山尚, 森本幸生, 武谷立

    第74回日本薬理学会西南部会 

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    Event date: 2021.11.20

    Language:Japanese   Presentation type:Oral presentation (general)  

  • フォルミン蛋白質Fhod3による大脳皮質錐体細胞の樹状突起スパインの形態制御

    Hikmawan Wahyu Sulistomo, 根本隆行, ○鹿毛陽子,藤井哉,尾藤晴彦,武谷立

    第94回日本生化学会大会 

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    Event date: 2021.11.3 - 2021.11.5

    Language:Japanese   Presentation type:Poster presentation  

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Awards 【 display / non-display

  • 平成17年度日本生体防御学会奨励賞

    2005.8   日本生体防御学会  

    武谷 立

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • 心筋サルコメアにおけるアクトミオシン架橋形成の制御機構

    Grant number:19K07355  2019 - 2022.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • スパインにおけるアクチン重合因子Fhod3の機能解明

    Grant number:18K06701  2018.04 - 2021.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • サルコメアにおける心拍動依存的な恒常性維持機構とその破綻

    2014.04 - 2018.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    本研究の目的は、横紋筋の収縮装置「サルコメア」の恒常性維持機構を、アクチン重合制御の観点から明らかにすると同時に、その破綻がもたらす病態を明らかにすることである。

  • サルコメアの形成・維持におけるアクチン重合機構の役割と制御

    2011.04 - 2014.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    サルコメアの形成・維持におけるアクチン重合機構の役割と制御

Other research activities 【 display / non-display

  • 査読をした

    2021.11

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    外国語雑誌査読論文

  • 査読をした

    2021.08

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    外国語雑誌査読論文

  • 査読をした

    2020.07

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    外国語雑誌査読論文

  • シンポジウムオーガナイザー

    2020.06

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    第72回日本細胞生物学会大会 シンポジウムオーガナイザー