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Affiliation |
Faculty of Medicine School of Medicine Department of Medical Sciences, Pharmacology |
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Professor |
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External Link |
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TAKEYA Ryu
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Research Areas 【 display / non-display 】
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Life Science / Pharmacology
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Life Science / Medical biochemistry
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Life Science / Pathological biochemistry
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Life Science / Cell biology
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Life Science / Cardiovascular surgery
Papers 【 display / non-display 】
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Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli. Reviewed
Maruta T, Hidaka K, Kouroki S, Koshida T, Kurogi M, Kage Y, Mizuno S, Shirasaka T, Yanagita T, Takahashi S, Takeya R, Tsuneyoshi I
PloS one 17 ( 10 ) e0275751 2022.10
Language：English Publishing type：Research paper (scientific journal)
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Extracellular signal-regulated kinase phosphorylation enhancement and NaV1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic pain: The efficacy and mechanism of pulsed radiofrequency therapy. Reviewed
Hidaka K, Maruta T, Koshida T, Kurogi M, Kage Y, Kouroki S, Shirasaka T, Takeya R, Tsuneyoshi I
Molecular pain 18 17448069221089784 2022.4
Language：English Publishing type：Research paper (scientific journal)
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Nursing pharmacology education and active-learning. Reviewed
Yanagita Toshihiko, Kanaoka Maki, Kinoshita Yumiko, Takeya Ryu
Folia Pharmacologica Japonica 157 ( 2 ) 104 - 109 2022.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Pharmacological Society
<p>Comprehensive pharmacology education in nursing based on the "Patient-oriented Pharmacology" is effective against the improvement of quality of pharmacotherapy and patient satisfaction. Two active learning programs of practical pharmacotherapy for nursing students have been performed in School of Nursing, University of Miyazaki; (1) pharmacotherapy role-play for interprofessional education (IPE) and (2) practical excise for Kampo medicine. Pharmacotherapy role-play for IPE was performed as joint lecture both medical students and nursing students. This pharmacotherapy role-play is named Case & Communication based approach (C&C approach), since it is studied through communication between physicians, nurses and patients based on cases presented beforehand. In the practical excise for Kampo medicine, nursing students studied Kampo medicines and tried to taste 9 frequently used Kampo medicines. These active-learning programs in nursing pharmacology education may be effective for better understanding of pharmacotherapy and patient's feeling, and improvement of students' motivation as a nurse.</p>
DOI： 10.1254/fpj.21100
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Differential effects of the formin inhibitor SMIFH2 on contractility and Ca2+ handling in frog and mouse cardiomyocytes Reviewed International journal
Koji Sakata, Sho Matsuyama, Nagomi Kurebayashi, Kengo Hayamizu, Takashi Murayama, Kunihide Nakamura, Kazuo Kitamura, Sachio Morimoto, Ryu Takeya
Genes to Cells 26 ( 8 ) 583 - 595 2021.8
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
Genetic mutations in actin regulators have been emerging as a cause of cardiomyopathy, although the functional link between actin dynamics and cardiac contraction remains largely unknown. To obtain insight into this issue, we examined the effects of pharmacological inhibition of formins, a major class of actin-assembling proteins. The formin inhibitor SMIFH2 significantly enhanced the cardiac contractility of isolated frog hearts, thereby augmenting cardiac performance. SMIFH2 treatment had no significant effects on the Ca2+ sensitivity of frog muscle fibers. Instead, it unexpectedly increased Ca2+ concentrations of isolated frog cardiomyocytes, suggesting that the inotropic effect is due to enhanced Ca2+ transients. In contrast to frog hearts, the contractility of mouse cardiomyocytes was attenuated by SMIFH2 treatment with decreasing Ca2+ transients. Thus, SMIFH2 has opposing effects on the Ca2+ transient and contractility between frog and mouse cardiomyocytes. We further found that SMIFH2 suppressed Ca2+ -release via type 2 ryanodine receptor (RyR2); this inhibitory effect may explain the species differences, since RyR2 is critical for Ca2+ transients in mouse myocardium but absent in frog myocardium. Although the mechanisms underlying the enhancement of Ca2+ transients in frog cardiomyocytes remain unclear, SMIFH2 differentially affects the cardiac contraction of amphibian and mammalian by differentially modulating their Ca2+ handling.
DOI： 10.1111/gtc.12873
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Fhod3 controls the dendritic spine morphology of specific subpopulations of pyramidal neurons in the mouse cerebral cortex Reviewed
Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, and Ryu Takeya
Cerebral Cortex 2020.11
Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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ラング・デール薬理学 第8版
H. P. Rang, J. M. Ritter, R. J. Flower, G. Henderson, 監訳 渡邊直樹（ Role： Joint translator）
エルゼビア・ジャパン 2018.12
Language：Japanese Book type：Textbook, survey, introduction
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ラング・デール薬理学 第8版
H. P. Rang, J. M. Ritter, R. J.Flower, G. Henderson監訳 渡邊直樹（ Role： Joint translator）
エルゼビア・ジャパン 2018.12
Language：Japanese Book type：Textbook, survey, introduction
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マッキー生化学 第６版
Trudy McKee ,James R.McKee, 監修 市川 厚, 監訳 福岡 伸一（ Role： Joint translator , 第18章 遺伝情報）
化学同人 2018.3
Language：Japanese Book type：Textbook, survey, introduction
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マッキー生化学 第４版
市川 厚, 福岡 伸一 他（ Role： Joint translator , 18章 遺伝情報）
化学同人 2010.3
Language：Japanese Book type：Textbook, survey, introduction
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マッキー生化学 第3版
市川 厚，福岡 伸一 他（ Role： Joint translator , 18章 遺伝情報）
化学同人 2003.10
Language：Japanese Book type：Textbook, survey, introduction
MISC 【 display / non-display 】
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心筋サルコメアの形成とその維持機構
武谷 立
宮崎県医師会医学会誌 （別冊） 40 ( 1 ) 1 - 6 2016.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other) Publisher：宮崎県医師会
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心筋の収縮装置「サルコメア」の形成の分子機構
武谷 立
生存科学 26 ( 1 ) 299 - 305 2015.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other) Publisher：公益財団法人 生存科学研究所
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薬理学ロールプレイ:Case & Communication based approach によるアクティブラーニング
柳田俊彦，根本隆行，武谷 立
日本薬理学会雑誌 146 ( 2 ) 115 - 118 2015.8
Language：Japanese Publishing type：Research paper, summary (national, other academic conference) Publisher：公益社団法人 日本薬理学会
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Regulation of superoxide-producing NADPH oxidases in nonphagocytic cells. Reviewed
Takeya R, Ueno N, Sumimoto H
Methods Enzymol. 2006
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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食細胞による微生物の取り込みと殺菌
水上 令子，武谷 立，住本 英樹
蛋白質核酸酵素 2006
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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アクチン核化重合因子Fhod1の肺胞マクロファージにおける役割
○三浦綾子，實松史幸，武谷 立
第95回日本薬理学会
Event date： 2022.3.7 - 2022.3.9
Language：Japanese Presentation type：Poster presentation
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神経細胞の形態制御におけるフォルミン蛋白質Fhod3の役割
Hikmawan Wahyu Sulistomo, 根本隆行, 鹿毛陽子, ○武谷立
生体運動研究合同班会議2022
Event date： 2022.1.7 - 2022.1.9
Language：Japanese Presentation type：Oral presentation (general)
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フォルミン蛋白質Fhod3の心筋症病因変異がもたらす機能変化
○坂田鋼治, 鹿毛陽子, 武谷立
生体運動研究合同班会議2022
Event date： 2022.1.7 - 2022.1.9
Language：Japanese Presentation type：Oral presentation (general)
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フォルミン阻害剤SMI-FH2による心機能の変容とその分子機序
○坂田鋼治, 松山翔, 呉林なごみ, 村山尚, 森本幸生, 武谷立
第74回日本薬理学会西南部会
Event date： 2021.11.20
Language：Japanese Presentation type：Oral presentation (general)
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フォルミン蛋白質Fhod3による大脳皮質錐体細胞の樹状突起スパインの形態制御
Hikmawan Wahyu Sulistomo, 根本隆行, ○鹿毛陽子，藤井哉，尾藤晴彦，武谷立
第94回日本生化学会大会
Event date： 2021.11.3 - 2021.11.5
Language：Japanese Presentation type：Poster presentation
Awards 【 display / non-display 】
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平成17年度日本生体防御学会奨励賞
2005.8 日本生体防御学会
武谷 立
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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サルコメアは回転トルクを生み出すか？
Grant number：22K19407 2022.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 挑戦的研究（萌芽）
Authorship：Principal investigator
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異種細胞間の細胞接着装置の恒常性維持機構の解析
Grant number：21K08183 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
三浦 綾子、
Authorship：Coinvestigator(s)
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心筋サルコメアにおけるアクトミオシン架橋形成の制御機構
Grant number：19K07355 2019 - 2022.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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スパインにおけるアクチン重合因子Fhod3の機能解明
Grant number：18K06701 2018.04 - 2021.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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サルコメアにおける心拍動依存的な恒常性維持機構とその破綻
2014.04 - 2018.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
本研究の目的は、横紋筋の収縮装置「サルコメア」の恒常性維持機構を、アクチン重合制御の観点から明らかにすると同時に、その破綻がもたらす病態を明らかにすることである。
Other research activities 【 display / non-display 】
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特別講演 共催セミナー 特別講演
2022.03
看護薬理学カンファレンス2022 in福岡 特別講演 共催セミナー 座長
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査読をした
2022.03
外国語雑誌査読論文
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査読をした
2021.11
外国語雑誌査読論文
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口頭発表オーガナイザー
2021.11
第94回日本生化学会大会 口頭発表オーガナイザー
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査読をした
2021.08
外国語雑誌査読論文