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Faculty of Medicine School of Medicine Department of Surgery, Hepato-Biliary-Pancreas Surgery |
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NANASHIMA Atsushi
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Research Areas 【 display / non-display 】
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Life Science / General surgery and pediatric surgery
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Life Science / Digestive surgery
Papers 【 display / non-display 】
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Nanashima A., Eguchi S., Hisaka T., Kawasaki Y., Yamashita Y.I., Ide T., Kuroki T., Yoshizumi T., Kitahara K., Endo Y., Utsunomiya T., Kajiwara M., Sakoda M., Okamoto K., Nagano H., Takami Y., Beppu T.
Cancers 15 ( 6 ) 1740 2023.3
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Cancers
Background: This study aims to clarify the perioperative risk factors and short-term prognosis of central bisectionectomy (CB) for hepatocellular carcinoma (HCC). Methods: Surgical data from 142 selected patients out of 171 HCC patients who underwent anatomical CB (H458) between 2005 and 2020 were collected from 17 expert institutions in a single-arm retrospective study. Results: Morbidities recorded by the International Study Group of Liver Surgery (ISGLS) from grade BC post-hepatectomy liver failure (PHLF) and bile leakage (PHBL), or complications requiring intervention were observed in 37% of patients. A multivariate analysis showed that increased blood loss (iBL) > 1500 mL from PHLF (risk ratio [RR]: 2.79), albumin level < 4 g/dL for PHBL (RR, 2.99), involvement of segment 1, a large size > 6 cm, or compression of the hepatic venous confluence or cava by HCC for all severe complications (RR: 5.67, 3.75, 6.51, and 8.95, respectively) (p < 0.05) were significant parameters. Four patients (3%) died from PHLF. HCC recurred in 50% of 138 surviving patients. The three-year recurrence-free and overall survival rates were 48% and 81%, respectively. Conclusions: Large tumor size and surrounding tumor involvement, or compression of major vasculatures and the related iBL > 1500 mL were independent risk factors for severe morbidities in patients with HCC undergoing CB.
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Prognostic value of repeat hepatectomy for hepatocellular carcinoma pationts Reviewed International journal
Nanashima A., Tanoue, Y., Hiyoshi, M., Imamura, N., Yano, K., Hamada, T., Kitamura, E., Kai, K., Tahira, K. and Nagayasu, T.
Anticancer Research 42 ( 9 ) 4553 - 4561 2022.9
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Novel analysis using magnetic resonance cholangiography for patients with pancreaticobiliary maljunction Invited Reviewed
Nanashima A., Komi M., Imamura N., Yazaki S., Hiyoshi M., Hamada T., Yano K., Nishida T., Enzaki M., Sakae T.
Surgery Today 52 ( 3 ) 385 - 394 2022.3
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Surgery Today
Purpose: We used a novel diagnostic Fourier transform (FT) algorithm of the entire extrahepatic bile duct (EHBD) measured by magnetic resonance cholangiography (MRC) to evaluate subtle deformation of bile duct lumen, indicating the malignant potential of EHBD, in patients with pancreaticobiliary maljunction (PBMJ) and in a comparative group of controls without PBMJ. Methods: From the workstation, the EHBD lumen was traced automatically and a 2D diagram cross section was measured at 0.5 mm-longitudinal intervals. The FT-based integrated power spectral density function value (FTPSDI) of the diameter or area (mm2 or mm4/Hz) and the phase value distribution entropy (PVDE) were also measured. Results: There were 16 patients with undilated PBMJ and 7 with dilated PBMJ. The control group comprised 10 patients with a normal bile duct, 20 with bile duct carcinoma (BDC), and 1 with primary sclerosing cholangitis. Both the diameter and area of the dilated bile ducts and the ducts with early- or advanced-stage BDC were significantly greater than those of the normal duct (p < 0.05). The undilated type of PBMJ tended to have a larger FTPSDI diameter than a normal bile duct, which had a smaller diameter than the dilated type of PBMJ or BDC. BDC had a significantly larger FTPSDI diameter (p < 0.05) and the cutoff value for accuracy was 168 mm2 Hz−1. Conclusion: The novel mathematical FTPSDI is a promising indicator of whether preventive EHBD resection is necessary for patients with PBMJ, which can be widely applied in the early diagnosis of other biliary diseases.
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Recent changes in surgical outcomes and preoperative biliary drainage with the increased use of neoadjuvant chemotherapy in pancreatic cancer patients undergoing pancreatoduodenectomy: a single-center retrospective study Reviewed
3 Imamura, N., Nanashima, A, Tsuchimochi, Y., Hamada, T., Kawakami, H. and Hiyoshi, M.
Gland Surgery 14 ( 4 ) 714 - 725 2025.4
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.21037/gs-2024-507
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Non-Cytotoxic photodynamic therapy with talaporfin sodium reduces the expression of CXCR4 and enhances chemotherapeutic efficacy in undifferentiated Reviewed
Kai,K., Ishizuka, T., Matsumoto, J., K Shimamawari, K., Mori, R., Fidya, Lkham-Erdene, B., Kubota, T., Ikenoue, M., Higuchi, K., Nanashima, A. and Hishikawa, Y.
Acta Histochemica et Cytochemica 58 ( 2 ) 2025.4
Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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消化器難治療癌シリーズV 肝細胞癌
七島篤志（ Role： Joint author , おわりに）
株式会社協和企画 2024.4
Language：Japanese Book type：Scholarly book
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Therapeutic applications: Photodynamic therapy using porphyrin compounds
Hamada T., Nanashima A.（ Role： Sole author）
Fluorescence-Guided Surgery: From Lab to Operation Room 2023.11 （ ISBN:9789811973727, 9789811973710 ）
Language：English Book type：Scholarly book
As a result of recent advances in endoscopes and optical fibers, optical engineering has been introduced to medical treatment in these years. Photodynamic therapy (PDT) is a promising treatment method that irradiates a tumor with a highly tumor-accumulating photosensitive agent and a laser with a specific wavelength and shows a cell-killing effect only on tumor cells with high drug concentration. It has already been applied clinically in the fields of pulmonary and digestive surgery, neurosurgery, ophthalmology, dermatology, and urology. As described in other chapters, photodynamic diagnosis (PDD), which is a method to diagnose the localization of tumors by irradiating biological tissues with light and detecting the fluorescence generated by photosensitive agents accumulated in tumors, is also being actively studied and applied clinically.
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肝胆膵高難度外科手術［Web動画付］第3版
旭吉雅秀，七島篤志（ Role： Joint author , 胆道再建）
医学書院 2023.6
Language：Japanese Book type：Scholarly book
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術中イメージング実践ガイド －ラボからオペ室まで－ Reviewed
濵田剛臣，七島篤志（ Role： Joint author , Ⅲ術中蛍光イメージングの実際[開発編]: 4. 治療への応用(1): ポルフィリン化合物を用いた光線力学的治療）
メジカルビュー 2020.9 （ ISBN:978-4758315371 ）
Total pages：339 Responsible for pages：310-320 Language：Japanese Book type：Scholarly book
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新DS Now No.4 胆道癌･膵癌に対する標準手術−手技修得へのナビゲート− Reviewed
長友謙三，濵田剛臣，七島篤志（ Role： Joint author , 膵体部癌に対する膵体尾部切除術）
メジカルビュー社 2019.8 （ ISBN:978-4-7583-1653-8 ）
Total pages：184 Responsible for pages：136-156 Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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【Acute Care Surgery入門-外傷対応の基礎知識】Open abdominal management-若手外科医が知っておくこと Reviewed
河野文彰，池ノ上実，宗像 駿，武野慎祐，七島篤志
臨床外科 79 ( 4 ) 395 - 402 2024.11
Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【必携 消化器・一般外科医のための外科解剖アトラス】食道・胃 食道癌頸部リンパ節郭清に必要な局所解剖 Reviewed
武野慎祐，河野文彰，田代耕盛，池ノ上実，七島篤志，井手慎介
手術 78 ( 4 ) 395 - 402 2024.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【診療】鏡視下甲状腺手術の現状と課題
河野文彰，池ノ上実，宗像 駿，武野慎祐，七島篤志
宮崎県医師会医学会誌 48 ( 1 ) 42 - 47 2024.3
Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【「緊急対応or経過観察」を見極める!新生児【診療】当院におけるNOMIの治療戦略の消化器症状アセスメント】疾患：消化管閉鎖 Invited International coauthorship
落合貴裕，河野文彰，田代耕盛，池ノ上実，古川貢之，落合秀信，武野慎祐，七島篤志
宮崎県医師会医学会誌 48 ( 1 ) 31 - 37 2024.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：東京医学社
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【胆道閉鎖症の研究update】患児末梢血中の母親由来キメラ細胞の検出とその臨床的意義 Invited Reviewed International coauthorship
桝屋隆太, 連 利博, Sami B.Kanaan, 春松敏夫, 武藤 充, 東間未来, 矢内俊裕, Anne M Stevens, J Lee Nelson, 中目和彦, 七島篤志, 家入里志
小児外科 56 ( 2 ) 117 - 121 2024.2
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：東京医学社
Presentations 【 display / non-display 】
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Non-Cytotoxic Photodynamic Therapy with Talaporfin Sodium Reduces the Expression of CXCR4 and Enhances Chemotherapeutic Efficacy in Undifferentiated Gastric Cancer Cell Line HGC27
Kai Kengo, Ishizuka Takumi, Matsumoto Jin, Shimamawari Koki, Mori Ryoma, Fidya, Lkham-Erdene Baljinnyam, Kubota Toshiki, Ikenoue Makoto, Higuchi Kazuhiro, Nanashima Atsushi, Hishikawa Yoshitaka
Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ 2025.4.26 日本組織細胞化学会
Event date： 2025.4.26
Language：English Presentation type：Oral presentation (general)
Gastric cancer (GC), particularly the undifferentiated type, is frequently associated with peritoneal metastasis, which significantly worsens prognosis due to its resistance to conventional treatments. Photodynamic therapy (PDT) is localized treatment using a photosensitizer (PS) activated by light of a specific wavelength to generate cytotoxic reactive oxygen species that induce cell death. Severe adverse events were reported from clinical trials investigating PDT for peritoneal dissemination conducted until the early 2000s, leaving its safety and clinical effectiveness unestablished. The present study explored whether “non-cytotoxic” PDT using talaporfin sodium (TS) could enhance efficacy of chemotherapeutic agents in undifferentiated GC cell line HGC27. Cell viability was evaluated with MTT assay following TS-PDT, and the synergistic effect between non-cytotoxic TS-PDT and anticancer drug SN-38 was assessed. Changes in expression of drug resistance markers were analyzed through qRT-PCR, Western blotting, and immunocytochemistry. We found that non-cytotoxic TS-PDT enhanced the efficacy of chemotherapy in the undifferentiated GC cell line and reduced the expression of C-X-C chemokine receptor type 4, a key marker associated with GC stem-like properties. These findings highlight the potential of non-cytotoxic TS-PDT as a synergistic treatment approach. We conclude that non-cytotoxic TS-PDT could enhance drug sensitivity and offers a promising therapeutic strategy for GC.
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What should acute care surgery be like in regional facilities?
Kawano Fumiaki, Tashiro Kousei, Ikenoue Makoto, Munakata Shun, Suzuki Yasuto, Takeno Shinsuke, Furukawa Kouji, Ochiai Hidenobu, Nanashima Atsushi
Japanese Journal of Acute Care Surgery 2025.4.10 The Japanese Society for the Acute Care Surgery
Event date： 2025.4.10
Language：Japanese Presentation type：Oral presentation (general)
We looked back on the 10 years of acute care surgery 〈ACS） at our department and discussed what type of ACS is required in facilities in regional cities. In our department, the emergency and critical care unit started in 2012, which required major changes in the surgical emergency treatment system. At the regional level, we focused on maintaining the existing emergency system, and we established a system in which severe injuries and trauma cases were concentrated in our department. At the facility level, ACS team was formed with existing surgeons to facilitate trauma care and actively intervene in trauma care. In addition, to maintain the team, we improved the on-call system and implemented complete division of labor in perioperative management. At the individual level, we performed daily surgical tasks with a specialty to maintain surgical skills and motivation. In addition, we made efforts to encourage young surgeons and residents to intervene in the practice in order to foster the Acute care surgeons. In this way, we believe that ACS in regional cities can be established by maintaining the existing emergency system and having existing surgeons create a system that is suited to the facilities.
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特集 臓器損傷治療の工夫 【手術手技】 腹部開放創陰圧治療法システムによるopen abdominal management
桝屋 隆太, 中目 和彦, 宗像 駿, 河野 文彰, 武野 慎祐, 七島 篤志, 家入 里志
小児外科 2025.2.25 東京医学社
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特集 Acute Care Surgery入門 外傷対応の基礎知識 Open abdominal management-若手外科医が知っておくべきこと
河野 文彰, 池ノ上 実, 宗像 駿, 武野 慎祐, 七島 篤志
臨床外科 2024.11.20 株式会社医学書院
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連載 外科医の私論 起きて半畳寝て一畳,どこにいても手術は一つ
七島 篤志
外科 2024.8.1 南江堂
Works 【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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GVHD誘導マウスでのサイトカイン阻害による胆道閉鎖症の炎症標的型治療法の開発
Grant number：23K08052 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
桝屋 隆太
Authorship：Coinvestigator(s)
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クリック反応技術と軸配位子糖鎖連結ポルフィリン錯体を融合した革新的PDTの開発
Grant number：22K08806 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
七島篤志
Authorship：Principal investigator
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FDG PET腫瘍診断と腫瘍遺伝子変異の関連に基づくテーラーメイド医療の開発
Grant number：26461857 2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
FDG PET腫瘍診断と腫瘍遺伝子変異の関連に基づくテーラーメイド医療の開発
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臨床実用を目指した癌幹細胞標的光線力学的療法の基礎研究
Grant number：26461045 2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
臨床実用を目指した癌幹細胞標的光線力学的療法の基礎研究
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糖鎖連結クロリンを用いたあたらし光線力学的療法による胆管癌の次世代局所治療法の開発
Grant number：25462120 2013.04 - 2016.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
光線力学的療法は、切除不能胆管癌に対する補助化学療法として効果が期待できる。一方で、光線過敏症などの副作用もあり、腫瘍特異成・抗腫瘍効果が高く副作用の少ない光感受性物質の開発がのぞまれる。新規光感受性物質と期待される糖鎖連結クロリンを用いた胆道癌に対する光線力学的療法について、現在使用されているタラポルフィリンナトリウム（レザフィリン）と比較検討した。細胞を用いた実験では、殺細胞効果・アポトーシス誘導効果が高いことが分かり、糖鎖連結クロリンが新規光感受性物質として期待できるという結果を得た。