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Faculty of Medicine School of Medicine Department of Surgery, Hepato-Biliary-Pancreas Surgery |
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NANASHIMA Atsushi
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Research Areas 【 display / non-display 】
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Life Science / General surgery and pediatric surgery
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Life Science / Digestive surgery
Papers 【 display / non-display 】
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Managing uncontrolled bleeding in elective surgery: The role of damage control techniques Reviewed
Nanashima A., Wada T., Kawano F., Hamada K., Taniguchi T., Furukawa K.
International Journal of Surgery Case Reports 128 111040 2025.3
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Surgery Case Reports
Introduction: The main text introduction expands on the initial introduction by providing a more detailed discussion of massive bleeding in elective surgeries and its challenges. It describes how traditional hemostatic procedures are essential but may not always be sufficient, especially in uncontrolled coagulopathy despite aggressive transfusion. It then introduces DCS as a well-established approach in trauma surgery, emphasizing its role in stabilizing patients with hemorrhagic shock, coagulopathy, hypothermia, and acidosis. It highlights that DCS can be a lifesaving intervention when unexpected massive bleeding occurs and justifies its use in patients with unstable vital signs or increased intra-abdominal pressure by our two experienced cases presentation. Case 1. A 76-year-old obese male diagnosed with advanced transverse colon cancer with regional balky lymph node metastasis was identified at the root of the regional colic vein trunk. A robotic surgical approach was changed to open laparotomy because of bleeding tendency due to fatty mesentery. During the balky node dissection, the root of the vein was injured and induced massive bleeding during the compressive hemostatic procedure. As the hypotensive control rapidly became quite tricky, DCS by gauze packing and covered by the commercial dressing kit with open abdominal management (OAM). The second look operation, by supporting the Restrictive Endovascular Balloon Occlusion of the Aorta, repaired the superior mesenteric vein's injured parts. He survived for nine months. Case 2. The 72-year-old male patient was diagnosed as solitary 3 cm of hepatocellular carcinoma at S6 with alcoholic liver cirrhosis. The laparoscopic limited hepatic resection was changed to the open laparotomy due to the bleeding tendency at the transected parenchyma. After accomplishing limited resection, massive hepatic venous bleeding occurred; DCS was decided due to continuing hypotension, oozed hemorrhage, and low platelet level with metabolic acidosis by peri-hepatic gauze packing around the right liver. The second look operation for remnant hemostasis and the de-packing with abdominal closure could be achieved without severe events. The postoperative course showed no hepatic failure, and they recovered during a hospital stay. Discussion: It describes how conventional hemostatic procedures are essential but may not always be sufficient, especially in uncontrolled coagulopathy despite aggressive transfusion. DCS is a well-established approach in trauma surgery, emphasizing its role in stabilizing patients with hemorrhagic shock, coagulopathy, hypothermia, and acidosis. The role of DCS is well known even in elective surgery in unforeseen emergency situations such as hemodynamic instability, severe coagulopathy, and prolonged surgery over 24 h. It highlights that DCS can be a lifesaving intervention when unexpected massive bleeding occurs and justifies its use in patients with unstable vital signs or increased intra-abdominal pressure, where prolonged surgery is not feasible. It reinforces that DCS was successfully utilized in the reported cases, leading to favorable second-look operations. Conclusion: The main text introduction is a more comprehensive and structured expansion of the initial introduction. While the initial version introduces the problem concisely, the revised introduction elaborates on the challenges of massive bleeding, the principles of DCS, and its potential role in elective surgeries before transitioning into the case reports.
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Nanashima A., Arai J., Hiyoshi M., Imamura N., Hamada T., Tsuchimochi Y., Shimizu I., Ochiai T., Kawakami H., Sato Y., Takashi W.
Turkish Journal of Surgery 41 ( 1 ) 5 - 18 2025.3
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Turkish Journal of Surgery
Objective: To elucidate surgical strategies for patients undergoing radical resection, in cases where solitary distant lymph node metastasis is identified intraoperatively, we investigated the prognostic significance of para-aortic lymph node (PALN) metastases and other regional lymph node (RLN) metastases in pancreatic carcinomas (PC) and biliary duct cancers (BDC). Material and Methods: This study retrospectively analyzed data from 181 PC patients and 116 BDC patients who underwent radical resections at two institutions between 1994 and 2021. Results: Among PC patients, metastases were observed in RLN and PALN in 54% and 9% of cases, respectively. Similarly, RLN and PALN metastases were present among BDC patients in 39% and 9% of cases, respectively. Survival analysis revealed that patients with BDC and PALN metastases exhibited significantly reduced disease-free (DFS) and overall survival (OS) compared to those without PALN involvement. Multivariate analysis identified PALN metastasis as an independent predictor of OS in BDC patients (p<0.05), while RLN metastasis was independently associated with DFS (p<0.05). Additional clinicopathological factors associated with PALN and RLN metastases were also identified. Preoperative serum levels of Duke Pancreas II monoclonal antibody were significantly elevated in patients with PALN metastases. Histological findings of lymphatic or perineural infiltration and hepatic or pancreatic invasion were independently associated with RLN metastases. Conclusion: Based on these findings, radical resection may be considered for PC patients with isolated PALN metastases only in the absence of additional adverse prognostic factors. Prospective clinical trials are warranted to further refine the criteria for surgical intervention when solitary PALN metastases are detected intraoperatively.
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Nanashima A., Hiyoshi M., Imamura N., Hamada T., Tsuchimochi Y., Shimizu I., Ochiai T., Ichihara A., Hamada K., Ichiki N., Kai K., Higuchi K.
Translational Cancer Research 14 ( 1 ) 461 - 472 2025.1
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Translational Cancer Research
Background: Progression of chronic liver dysfunction influenced by long-term chemotherapy or repeated hepatectomy might be related to patient overall survival as well as tumor factors in colorectal liver metastasis (CLM) patients. Our aim of this study was to clarify the relationship between fibrotic liver damage and malignant behaviors of CLM malignancy or its long-term survivals by the retrospective cohort study. Methods: We examined the relationship between tumor-related factors or six liver fibrosis-associated parameters, including platelet count, hyaluronic acid (HA), mac-2 binding protein glycosylation isomer (M2BPGi), type IV collagen 7S (T4C7), aspartate aminotransferase-to-platelet ratio index (APRI), The fibrosis-4 (Fib-4) index, and clinicopathological parameters, surgical records, and postoperative patient survival in the 45 consecutive patients with CLM who underwent radical hepatectomy. Results: Fibrotic parameters were platelet count of 23.0±8.5 ×104/μL, HA level of 68.9±82.3 ng/mL, M2BPGi of 0.87±0.48 ng/mL, and type IV collagen level of 5.74±3.76 ng/mL. Platelet count was significantly correlated with HA level (P<0.05) and tended to be correlated with M2BPGi levels (P=0.056). HA level was significantly associated with albumin level (P<0.05). Overall survival in this series showed five-year overall survivors after hepatectomy in 44 patients (98%), but cancer-related deaths were observed in only one patient. Patients with higher grades and increased bilirubin levels demonstrated significantly lower cancer-free survival (P<0.05), but fibrotic parameters were not associated with prognostic factors. Conclusions: Fibrotic markers indicating chemotherapy or repeated surgical liver injury were not significant predictive factors reflecting cancer malignant behaviors or patient overall survival, contrary to our hypothesis. The current overall survival status using various modalities for cancer recurrence is satisfactory under our present perioperative management.
DOI： 10.21037/tcr-24-1138
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Nanashima A., Hamada T., Hiyoshi M., Imamura N., Tsuchimochi Y., Shimizu I., Nagata K., Kawakami H.
Clinical Journal of Gastroenterology 17 ( 3 ) 490 - 496 2024.6
Authorship：Lead author, Corresponding author Language：English Publishing type：Case report Publisher：Clinical Journal of Gastroenterology
Nowadays, the novel molecular targeting chemotherapy provides possibility of safe hepatectomy for progressive hepatocellular carcinoma (HCC). Further, combination of the conventional transarterial chemoembolization (TACE) may add an effect of tumor shrink. We present a successful radical hepatectomy for a large HCC located in segment 1 accompanied with the preoperative Lenvatinib (LEN)-TACE sequential treatment. We present a woman patient without any complaints who had a 7 cm-in-size of solitary HCC compressing vena cava and right portal pedicle. To achieve radical hepatectomy by tumor shrinking, LEN-TACE for 2 months. After confirming downsizing or devascularization of the HCC, we scheduled radical posterior sectionectomy combined with caudate lobectomy according to tumor location and expected future remnant liver volume from three-dimensional computed tomography simulation before surgery. Under the thoraco-abdominal incision laparotomy, we safely achieved scheduled radical hepatectomy without any vascular injuries. The postoperative course was uneventful and no tumor recurrence were observed for 1 year. Histological findings showed the Japan TNM stage III HCC with 70% necrosis. The multi-modal strategy of LEN-TACE followed by radical hepatectomy by confirming downsizing or devascularization in tumor is supposed to be useful and would be a preoperative chemotherapy option, and promising for curative treatment in HCC patients with progressive or large HCC, which may lead to safety by prevention surrounding major vascular injury.
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Nanashima A., Hiyoshi M., Imamura N., Hamada T., Tsuchimochi Y., Wada T., Shimizu I., Ochiai T.
Turkish Journal of Surgery 40 ( 4 ) 283 - 295 2024.3
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Turkish Journal of Surgery
Objective: We examined the relation between several fibrotic markers reflecting liver parenchymal injury and conventional liver function or surgical outcomes in 67 patients with cholangiocarcinoma who underwent biliary drainage for obstructive jaundice followed by surgical resection. Material and Methods: We examined conventional clinicopathological factors, six hepatic fibrosis parameters, including platelet count, hyaluronic acid, Mac-2 binding protein glycosylation isomer (M2BPGi), type IV collagen 7S, aspartate aminotransferase-to-platelet ratio index (APRI), and FIB-4 index before hepatectomy, and surgical outcomes or long-term prognosis. Results: Obstructive jaundice was observed in 57% of the patients, a history of biliary diseases in 7.5%, and chronic hepatic injuries in 17.9%. M2BPGi was significantly higher in patients with obstructive jaundice as the primary sign (p< 0.05), the FIB-4 index was significantly correlated with patient age (p< 0.01), and serum hyaluronic acid and T4C7 levels were significantly increased in distal cholangiocarcinoma (CC). No markers were associated with the histological hepatic fibrotic index, tumor-related factors, or postoperative morbidities. Tumor relapse was observed in 37% of patients, and cancer-related death was observed in 25%. A higher FIB-4 index was significantly associated with shorter cancer-free survival (p< 0.05). Cox multivariate analysis showed that bilirubin levels, poor histological cancer differentiation, and absence of fibrotic markers were associated with cancer-free, cancer-specific overall, and overall survival. Conclusion: Although a sufficient relation exists between these markers and elastographic or histological fibrotic indexes, the clinical significance of measuring conventional fibrotic markers might no longer be necessary in future studies.
Books 【 display / non-display 】
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消化器難治療癌シリーズV 肝細胞癌
七島篤志（ Role： Joint author , おわりに）
株式会社協和企画 2024.4
Language：Japanese Book type：Scholarly book
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Therapeutic applications: Photodynamic therapy using porphyrin compounds
Hamada T., Nanashima A.（ Role： Sole author）
Fluorescence-Guided Surgery: From Lab to Operation Room 2023.11 （ ISBN:9789811973727, 9789811973710 ）
Language：English Book type：Scholarly book
As a result of recent advances in endoscopes and optical fibers, optical engineering has been introduced to medical treatment in these years. Photodynamic therapy (PDT) is a promising treatment method that irradiates a tumor with a highly tumor-accumulating photosensitive agent and a laser with a specific wavelength and shows a cell-killing effect only on tumor cells with high drug concentration. It has already been applied clinically in the fields of pulmonary and digestive surgery, neurosurgery, ophthalmology, dermatology, and urology. As described in other chapters, photodynamic diagnosis (PDD), which is a method to diagnose the localization of tumors by irradiating biological tissues with light and detecting the fluorescence generated by photosensitive agents accumulated in tumors, is also being actively studied and applied clinically.
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肝胆膵高難度外科手術［Web動画付］第3版
旭吉雅秀，七島篤志（ Role： Joint author , 胆道再建）
医学書院 2023.6
Language：Japanese Book type：Scholarly book
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術中イメージング実践ガイド －ラボからオペ室まで－ Reviewed
濵田剛臣，七島篤志（ Role： Joint author , Ⅲ術中蛍光イメージングの実際[開発編]: 4. 治療への応用(1): ポルフィリン化合物を用いた光線力学的治療）
メジカルビュー 2020.9 （ ISBN:978-4758315371 ）
Total pages：339 Responsible for pages：310-320 Language：Japanese Book type：Scholarly book
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新DS Now No.4 胆道癌･膵癌に対する標準手術−手技修得へのナビゲート− Reviewed
長友謙三，濵田剛臣，七島篤志（ Role： Joint author , 膵体部癌に対する膵体尾部切除術）
メジカルビュー社 2019.8 （ ISBN:978-4-7583-1653-8 ）
Total pages：184 Responsible for pages：136-156 Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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【臓器損傷治療の工夫】手術手技 腹部開放創陰圧治療法システムによるopen abdominal management Invited Reviewed
桝屋隆太, 中目和彦, 宗像 駿, 河野文彰, 武野慎祐, 七島篤志, 家入里志
小児外科 57 ( 2 ) 231 - 235 2025.2
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【診療】鏡視下甲状腺手術の現状と課題 Invited
河野文彰，池ノ上実，宗像 駿，武野慎祐，七島篤志
宮崎県医師会医学会誌 48 ( 1 ) 42 - 47 2024.11
Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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特集【Acute Care Surgery入門-外傷対応の基礎知識】Open abdominal management-若手外科医が知っておくこと Invited Reviewed
河野文彰，池ノ上実，宗像 駿，武野慎祐，七島篤志
臨床外科 79 ( 4 ) 395 - 402 2024.11
Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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特集 必携 消化器・一般外科医のための外科解剖アトラス【I 食道・胃1】食道癌頸部リンパ節郭清に必要な局所解剖 Invited Reviewed
武野慎祐，河野文彰，田代耕盛，池ノ上実，七島篤志，井手慎介
手術 78 ( 4 ) 395 - 402 2024.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【診療】当院におけるNOMIの治療戦略 Invited Reviewed
落合貴裕，河野文彰，田代耕盛，池ノ上実，古川貢之，落合秀信，武野慎祐，七島篤志
宮崎県医師会医学会誌 48 ( 1 ) 31 - 37 2024.3
Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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Salvage Esophagectomy after Photodynamic Therapy for Secondary Squamous Cell Carcinoma in a Patient with a History of Complete Response to Chemoradiotherapy for Unresectable Advanced Esophageal Neuroendocrine Carcinoma
Araki Yusuke, Takeno Shinsuke, Ikenoue Makoto, Tashiro Kosei, Kawano Fumiaki, Ochiai Takahiro, Shimizu Ikko, Chiyotanda Teru, Tahira Kosei, Ota Yusuke, Nakashima Koji, Nanashima Atsushi
Nihon Kikan Shokudoka Gakkai Kaiho 2025.6.10 The Japan Broncho-esophagological Society
Event date： 2025.6.10
Language：English Presentation type：Oral presentation (general)
Esophageal neuroendocrine carcinoma (NEC) is a relatively rare esophageal malignancy with high histological grade and poor prognosis. Chemotherapy with or without radiation is recommended because NEC is often detected at an advanced stage and the recurrence rate is relatively high. For esophageal cancer, photodynamic therapy (PDT) is indicated after chemoradiotherapy (CRT), and salvage surgery is rarely performed afterwards. We report here a case in which PDT and salvage surgery were performed for secondary esophageal squamous cell carcinoma after esophageal NEC showed complete response to CRT. Eighteen months before this presentation, a 71-year-old woman underwent CRT for esophageal NEC (cT4b (trachea) N2M0 Stage IV) and no residual lesion was detected. Upper gastrointestinal endoscopy revealed multiple superficial-type squamous cell carcinomas in the esophagus at 25, 26, and 38 cm from the incisors. The lesion 38 cm from the incisors had invaded to the submucosal layer and the others represented in situ carcinomas. PDT was performed twice for all lesions, but residual tumor remained at 38 cm from the incisors. Ivor Lewis esophagectomy was performed because the earlier NEC had invaded to the trachea before CRT. Intraoperative findings included edema and scarring of the esophageal wall. The postoperative course was good and the patient was discharged on postoperative day 23.
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Characteristics of distal bile duct cancer preoperatively diagnosed as pancreatic head cancer
Hiyoshi Masahide, Nanashima Atsushi, Sato Yuichiro
Tando 2025.5.31 Japan Biliary Association
Event date： 2025.5.31
Language：Japanese Presentation type：Oral presentation (general)
We investigated the differences among patients with distal bile duct cancer with severe pancreatic invasion and were preoperatively diagnosed with pancreatic head cancer (Pre-PDAC group), patients with typical distal bile duct cancer (BDC group), and patients with pancreatic head cancer (PDAC group). Among 69 patients with distal bile duct cancer, 15 (21.7%) did not undergo surgical resection, and 54 (78.3%) underwent pancreaticoduodenectomy. Among the resected cases, 9 (16.7%) were classified as Pre-PDAC. The median survival time (MST) in the Pre-PDAC group was 20.9 months, significantly poorer than 106.8 months in the BDC group. No significant difference in MST was observed between the non-resected group (12.0 months), the Pre-PDAC group (20.9 months), and the PDAC group (32.9 months). The 2-year relapse-free survival rate was significantly lower in the Pre-PDAC group (25.0%) than in the BDC group (60.0%), and liver metastasis was frequently observed upon recurrence.
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河野 文彰, 千代反田 顕, 中目 和彦, 明利 聡瑠, 福島 剛, 佐藤 勇一郎, 山口 秀樹, 池ノ上 実, 宗像 駿, 樋口 和宏, 武野 慎祐, 七島 篤志
Endocrinology Diabetes and Metabolism Case Reports 2025.5.14 Bioscientifica
Event date： 2025.5.14
Language：English Presentation type：Oral presentation (general)
Summary
Spindle epithelial tumor with thymic-like elements (SETTLE) is an extremely rare tumor that occurs primarily in the thyroid gland. Histologically, SETTLE is characterized by the presence of spindle-shaped epithelial cells and glandular structures. However, it is known that diagnosis via fine-needle aspiration cytology can be challenging. SETTLE predominantly occurs in younger individuals and has a less favorable prognosis compared to differentiated thyroid carcinoma. Therefore, ensuring accurate diagnosis and appropriate treatment is crucial. We encountered a case of spindle epithelial tumor with thymus-like differentiation in a 10-year-old patient for whom the preoperative diagnosis was successfully established through fine-needle aspiration cytology, which facilitated appropriate surgical resection. Comprehensive histopathological examination and immunohistochemical analysis are essential to ensure appropriate management and surveillance of SETTLE.
Learning points
A rare thyroid tumor, spindle epithelial tumor with thymic-like elements (SETTLE), was diagnosed preoperatively and treated surgically.
SETTLE presents with characteristic histological features that must be recognized for accurate diagnosis. In addition, diagnosis through cytology is often challenging.
The primary treatment for SETTLE is surgical intervention as radiotherapy and pharmacological treatments are generally not expected to be highly effective.
Radical resection is the only effective treatment, making the selection of the surgical procedure according to the stage of the disease essential. -
Non-Cytotoxic Photodynamic Therapy with Talaporfin Sodium Reduces the Expression of CXCR4 and Enhances Chemotherapeutic Efficacy in Undifferentiated Gastric Cancer Cell Line HGC27
Kai Kengo, Ishizuka Takumi, Matsumoto Jin, Shimamawari Koki, Mori Ryoma, Fidya, Lkham-Erdene Baljinnyam, Kubota Toshiki, Ikenoue Makoto, Higuchi Kazuhiro, Nanashima Atsushi, Hishikawa Yoshitaka
Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ 2025.4.26 日本組織細胞化学会
Event date： 2025.4.26
Language：English Presentation type：Oral presentation (general)
Gastric cancer (GC), particularly the undifferentiated type, is frequently associated with peritoneal metastasis, which significantly worsens prognosis due to its resistance to conventional treatments. Photodynamic therapy (PDT) is localized treatment using a photosensitizer (PS) activated by light of a specific wavelength to generate cytotoxic reactive oxygen species that induce cell death. Severe adverse events were reported from clinical trials investigating PDT for peritoneal dissemination conducted until the early 2000s, leaving its safety and clinical effectiveness unestablished. The present study explored whether “non-cytotoxic” PDT using talaporfin sodium (TS) could enhance efficacy of chemotherapeutic agents in undifferentiated GC cell line HGC27. Cell viability was evaluated with MTT assay following TS-PDT, and the synergistic effect between non-cytotoxic TS-PDT and anticancer drug SN-38 was assessed. Changes in expression of drug resistance markers were analyzed through qRT-PCR, Western blotting, and immunocytochemistry. We found that non-cytotoxic TS-PDT enhanced the efficacy of chemotherapy in the undifferentiated GC cell line and reduced the expression of C-X-C chemokine receptor type 4, a key marker associated with GC stem-like properties. These findings highlight the potential of non-cytotoxic TS-PDT as a synergistic treatment approach. We conclude that non-cytotoxic TS-PDT could enhance drug sensitivity and offers a promising therapeutic strategy for GC.
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What should acute care surgery be like in regional facilities?
Kawano Fumiaki, Tashiro Kousei, Ikenoue Makoto, Munakata Shun, Suzuki Yasuto, Takeno Shinsuke, Furukawa Kouji, Ochiai Hidenobu, Nanashima Atsushi
Japanese Journal of Acute Care Surgery 2025.4.10 The Japanese Society for the Acute Care Surgery
Event date： 2025.4.10
Language：Japanese Presentation type：Oral presentation (general)
We looked back on the 10 years of acute care surgery 〈ACS） at our department and discussed what type of ACS is required in facilities in regional cities. In our department, the emergency and critical care unit started in 2012, which required major changes in the surgical emergency treatment system. At the regional level, we focused on maintaining the existing emergency system, and we established a system in which severe injuries and trauma cases were concentrated in our department. At the facility level, ACS team was formed with existing surgeons to facilitate trauma care and actively intervene in trauma care. In addition, to maintain the team, we improved the on-call system and implemented complete division of labor in perioperative management. At the individual level, we performed daily surgical tasks with a specialty to maintain surgical skills and motivation. In addition, we made efforts to encourage young surgeons and residents to intervene in the practice in order to foster the Acute care surgeons. In this way, we believe that ACS in regional cities can be established by maintaining the existing emergency system and having existing surgeons create a system that is suited to the facilities.
Works 【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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GVHD誘導マウスでのサイトカイン阻害による胆道閉鎖症の炎症標的型治療法の開発
Grant number：23K08052 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
桝屋 隆太
Authorship：Coinvestigator(s)
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クリック反応技術と軸配位子糖鎖連結ポルフィリン錯体を融合した革新的PDTの開発
Grant number：22K08806 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
七島篤志
Authorship：Principal investigator
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FDG PET腫瘍診断と腫瘍遺伝子変異の関連に基づくテーラーメイド医療の開発
Grant number：26461857 2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
FDG PET腫瘍診断と腫瘍遺伝子変異の関連に基づくテーラーメイド医療の開発
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臨床実用を目指した癌幹細胞標的光線力学的療法の基礎研究
Grant number：26461045 2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
臨床実用を目指した癌幹細胞標的光線力学的療法の基礎研究
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糖鎖連結クロリンを用いたあたらし光線力学的療法による胆管癌の次世代局所治療法の開発
Grant number：25462120 2013.04 - 2016.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
光線力学的療法は、切除不能胆管癌に対する補助化学療法として効果が期待できる。一方で、光線過敏症などの副作用もあり、腫瘍特異成・抗腫瘍効果が高く副作用の少ない光感受性物質の開発がのぞまれる。新規光感受性物質と期待される糖鎖連結クロリンを用いた胆道癌に対する光線力学的療法について、現在使用されているタラポルフィリンナトリウム（レザフィリン）と比較検討した。細胞を用いた実験では、殺細胞効果・アポトーシス誘導効果が高いことが分かり、糖鎖連結クロリンが新規光感受性物質として期待できるという結果を得た。