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Faculty of Medicine School of Medicine Department of Surgery, Hepato-Biliary-Pancreas Surgery |
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Related SDGs |
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NANASHIMA Atsushi
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Research Areas 【 display / non-display 】
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Life Science / General surgery and pediatric surgery
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Life Science / Digestive surgery
Papers 【 display / non-display 】
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Postoperative Outcomes and Strategic Refinement in Intraductal Papillary Mucinous Neoplasm Management Reviewed
Nanashima A, Imamura N, Hiyoshi M, Tsuchimochi Y, Wada T, Hamada T, Suzuki Y, Araki Y, Hosokawa A, Kawakami H.
Cancer diagnosis & prognosis 6 ( 2 ) 291 - 302 2026.3
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.21873/cdp.10528
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Surgical Outcomes and Diagnostic Concordance in Patients With Pancreatic Neuroendocrine Tumors Undergoing Pancreatectomy: A Retrospective Cohort Study. Reviewed International journal
Nanashima A, Hiyoshi M, Imamura N, Tsuchimochi Y, Wada T, Hamada T, Suzuki Y, Araki Y
Cancer diagnosis & prognosis 6 ( 1 ) 52 - 61 2026.1
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Cancer Diagnosis and Prognosis
Background/Aim: Pancreatic neuroendocrine tumors (PanNETs) are heterogeneous neoplasms for which surgical resection remains the only potentially curative therapy. However, preoperative diagnostic accuracy – particularly tumor grading – often varies, complicating treatment decisions. This study evaluated diagnostic concordance between preoperative assessments and postoperative pathology, as well as surgical outcomes and prognostic factors in patients undergoing pancreatectomy for PanNETs. Patients and Methods: We retrospectively reviewed the clinical records of 32 patients who underwent surgical resection for PanNETs. Patient demographics, tumor characteristics, surgical procedures, and postoperative outcomes were analyzed. Preoperative imaging and cytology-based diagnoses were compared with final pathological findings to evaluate diagnostic concordance. Prognostic factors were assessed using Kaplan–Meier survival analysis. Results: Histological grading of resected specimens showed G1 in 53%, G2 in 41%, and G3/NEC in 6%, with a 38% discordance rate from preoperative biopsy. Lymphatic, venous, and perineural invasions were identified in 16%, 44%, and 13% of cases. Lymph node metastasis occurred in 22%. Among 30 patients with follow-up >12 months, eight developed recurrence, most commonly in the liver. The 3-year and 5-year disease-free survival (DFS) rates were 78% and 69%, while overall survival (OS) rates were 96% and 91%. Tumor number >2 and histologic grade G3 were significantly associated with reduced DFS (p<0.05). Lymphatic invasion and metachronous liver metastasis were significantly associated with reduced OS (p<0.01 and p<0.05, respectively). Histological grading mismatch was not associated with survival outcomes. Conclusion: Pancreatectomy for PanNETs is a safe and effective treatment with favorable long-term outcomes. Histological factors such as tumor grade, lymphatic invasion, and tumor number significantly predict recurrence and survival.
DOI： 10.21873/cdp.10506
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Comparison of postoperative results between types of pancreaticoenteral anastomosis after pancreaticoduodenectomy Reviewed International journal
Nanashima A., Arai J., Imamura N., Hiyoshi M., Tsuchimochi Y., Wada T., Hamada T.
Gland Surgery 14 ( 12 ) 2440 - 2455 2025.12
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Gland Surgery
Background: Pancreatic anastomosis has been developed, and each anastomosis has its pros and cons. This study investigated the prevalence of postoperative complications, particularly pancreatic fistula (POPF), among five types of pancreatoenteric anastomoses to determine the optimal anastomosis for patients undergoing pancreatectomy. Methods: This study retrospectively and consecutively analyzed the data of 365 patients who underwent pancreatectomy with pancreaticoenteral anastomosis at two academic institutions from 1994 to 2024. Pancreaticogastrostomy via invagination was performed in 24 patients (group PG). For pancreaticojejunal anastomosis, we performed an end-to-end invagination procedure on eight patients (group PJI), two-layer suturing procedure on 96 patients (group PJT), Kakita procedure on 55 patients (group K), and modified Blumgart procedure on 182 patients (group B). Results: Group B had the shortest hospital stay and fastest resumption of oral intake. Groups PG and PJI exhibited higher grade B/C POPF rates and prolonged ascites. The potential benefits of group B included reduced hospitalization period and enhanced recovery owing to decreased POPF rates. Habitual alcohol consumption and high preoperative creatinine levels increased the risk of POPF, whereas external drainage issues and blood loss contributed to prolonged ascites. In particular, habitual alcohol consumption [relative risk (RR) =2.42], group K anastomosis (RR =2.79), soft pancreatic texture (RR =2.48), delayed oral intake (≥4 days; RR =2.78), and complete external drainage (RR =8.68) were independent predictors of POPF. Conclusions: Modified Blumgart procedure is an optimal pancreaticoenteral anastomosis technique for avoiding POPF. Early oral intake has emerged as a protective factor, highlighting its role in improving postoperative outcomes. Surgeons should prioritize intraoperative blood conservation, perioperative nutritional support, and appropriate anastomotic selection to enhance surgical success.
DOI： 10.21037/gs-2025-380
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Impact of underlying liver etiology on post-hepatectomy survival outcomes in hepatocellular carcinoma patients Reviewed International journal
Nanashima A., Arai J., Imamura N., Hiyoshi M., Tsuchimochi Y., Wada T.
Translational Cancer Research 14 ( 12 ) 8556 - 8566 2025.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Translational Cancer Research
Background: The underlying etiology of liver disease, such as metabolic dysfunction-associated steatotic liver diseases (MASLDs) or alcohol-related liver injury, significantly affects liver function and regenerative capacity. In hepatocellular carcinoma (HCC) patients undergoing hepatectomy, these background factors may influence postoperative outcomes and long-term survival. This study aimed to evaluate the impact of different etiologies of liver disease on survival outcomes following curative hepatectomy in patients with HCC. Methods: We retrospectively analyzed patients with HCC who underwent curative hepatectomy at two academic institutions. Background liver disease was classified according to etiology, including viral liver disease (VLD), alcohol-related liver disease (ALD), MASLD, and others. Survival outcomes were evaluated and compared across etiological groups at two institutions from 1994 to 2023. Results: Patients with VLD, ALD, and MASLD exhibited significantly elevated rates of advanced liver fibrosis (P<0.001), while vascular involvement was less frequent in MASLD cases. No significant differences in tumor stage, tumor markers, or postoperative complications were found among the etiologies. However, tumor recurrence was significantly more common in the VLD and ALD groups (P<0.001), and HCC-related deaths were most frequent in the VLD and other/unknown groups. MASLD patients presented the most favorable outcomes, with a 5-year recurrence-free survival (RFS) of 54% and a 10-year overall survival (OS) of 100%, significantly better than VLD (RFS 31%, OS 49%; P<0.01). Multivariate analysis revealed that VLD, vascular invasion, R1 margin, and poor liver function were independent predictors of recurrence and poor OS. Conversely, MASLD was not a significant risk factor for recurrence and was independently associated with better survival (P<0.05). Conclusions: MASLD-related HCC represents a distinct clinical entity with relatively indolent tumor behavior and better-preserved liver function. Recognizing the prognostic implications of MASLD-related HCC is essential for optimizing surgical indications and developing etiology-specific treatment strategies.
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Nanashima A., Arai J., Hiyoshi M., Imamura N., Hamada T., Tsuchimochi Y., Shimizu I., Ochiai T., Kawakami H., Sato Y., Takashi W.
Turkish Journal of Surgery 41 ( 1 ) 5 - 18 2025.3
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Turkish Journal of Surgery
Objective: To elucidate surgical strategies for patients undergoing radical resection, in cases where solitary distant lymph node metastasis is identified intraoperatively, we investigated the prognostic significance of para-aortic lymph node (PALN) metastases and other regional lymph node (RLN) metastases in pancreatic carcinomas (PC) and biliary duct cancers (BDC). Material and Methods: This study retrospectively analyzed data from 181 PC patients and 116 BDC patients who underwent radical resections at two institutions between 1994 and 2021. Results: Among PC patients, metastases were observed in RLN and PALN in 54% and 9% of cases, respectively. Similarly, RLN and PALN metastases were present among BDC patients in 39% and 9% of cases, respectively. Survival analysis revealed that patients with BDC and PALN metastases exhibited significantly reduced disease-free (DFS) and overall survival (OS) compared to those without PALN involvement. Multivariate analysis identified PALN metastasis as an independent predictor of OS in BDC patients (p<0.05), while RLN metastasis was independently associated with DFS (p<0.05). Additional clinicopathological factors associated with PALN and RLN metastases were also identified. Preoperative serum levels of Duke Pancreas II monoclonal antibody were significantly elevated in patients with PALN metastases. Histological findings of lymphatic or perineural infiltration and hepatic or pancreatic invasion were independently associated with RLN metastases. Conclusion: Based on these findings, radical resection may be considered for PC patients with isolated PALN metastases only in the absence of additional adverse prognostic factors. Prospective clinical trials are warranted to further refine the criteria for surgical intervention when solitary PALN metastases are detected intraoperatively.
Books 【 display / non-display 】
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消化器難治療癌シリーズV 肝細胞癌
七島篤志（ Role： Joint author , おわりに）
株式会社協和企画 2024.4
Language：Japanese Book type：Scholarly book
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おわりに.
七島篤志（ Role： Sole author , 消化器難治療癌シリーズV 肝細胞癌）
一般財団法人日本消化器病学会 2024.4
Language：Japanese Book type：Scholarly book
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Therapeutic applications: Photodynamic therapy using porphyrin compounds
Hamada T., Nanashima A.（ Role： Sole author）
Fluorescence-Guided Surgery: From Lab to Operation Room 2023.11 （ ISBN:9789811973727, 9789811973710 ）
Language：English Book type：Scholarly book
As a result of recent advances in endoscopes and optical fibers, optical engineering has been introduced to medical treatment in these years. Photodynamic therapy (PDT) is a promising treatment method that irradiates a tumor with a highly tumor-accumulating photosensitive agent and a laser with a specific wavelength and shows a cell-killing effect only on tumor cells with high drug concentration. It has already been applied clinically in the fields of pulmonary and digestive surgery, neurosurgery, ophthalmology, dermatology, and urology. As described in other chapters, photodynamic diagnosis (PDD), which is a method to diagnose the localization of tumors by irradiating biological tissues with light and detecting the fluorescence generated by photosensitive agents accumulated in tumors, is also being actively studied and applied clinically.
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肝胆膵高難度外科手術［Web動画付］第3版
旭吉雅秀，七島篤志（ Role： Joint author , 胆道再建）
医学書院 2023.6
Language：Japanese Book type：Scholarly book
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術中イメージング実践ガイド －ラボからオペ室まで－ Reviewed
濵田剛臣，七島篤志（ Role： Joint author , Ⅲ術中蛍光イメージングの実際[開発編]: 4. 治療への応用(1): ポルフィリン化合物を用いた光線力学的治療）
メジカルビュー 2020.9 （ ISBN:978-4758315371 ）
Total pages：339 Responsible for pages：310-320 Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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論説 シン・私の考える～医学教育に使えた名言･格言〜Quotes and aphorisms that could be used in surgical and medical education
七島篤志
宮崎県医師会医学会誌 49 ( 2 ) 117 - 123 2025.9
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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その他 地方都市施設におけるacute care surgeryのあり方とは？―当院の10年を振り返って見えてきた課題と対策―
河野文彰，田代耕盛，池ノ上実，宗像 駿，鈴木康人，武野慎祐，古川貢之，落合秀信，七島篤志
Japanese Journal of Acute Care Surgery 15 ( 1 ) 97 - 100 2025.4
Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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特集 臓器損傷治療の工夫【手術手技】腹部開放創陰圧治療法システムによるopen abdominal management Invited Reviewed
桝屋隆太, 中目和彦, 宗像 駿, 河野文彰, 武野慎祐, 七島篤志, 家入里志
小児外科 57 ( 2 ) 231 - 235 2025.2
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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ストーマ術後ケアVR活用：宮大などベンチャー設立へ．
七島篤志
宮崎日日新聞 23 - 23 2024.11
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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【診療】鏡視下甲状腺手術の現状と課題 Invited
河野文彰，池ノ上実，宗像 駿，武野慎祐，七島篤志
宮崎県医師会医学会誌 48 ( 1 ) 42 - 47 2024.11
Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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術前CTにて脾静脈の走行異常を認識し、安全に腹腔鏡下胃切除術を施行した胃癌の１例．
樋口和宏，宗像 駿，千代反田顕，池ノ上実，河野文彰，武野慎祐，七島篤志
第38回日本内視鏡外科学会総
Event date： 2025.12.11 - 2025.12.13
Language：Japanese Presentation type：Oral presentation (general)
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パネルディスカッション5-1直腸癌に対する術前治療の功罪1：直腸癌に対する術前治療の短期成績と適応症例の検討：当院におけるCRT およびTNT の後ろ向き評価よびTNT の後ろ向き評価.
濵田朗子，山田和之介，武野慎祐，市原明子，市来伸彦，千代反田顕，坂元紀彦，古島理紗子，七島篤志
第87回日本臨床外科学会学術集会
Event date： 2025.11.20 - 2025.11.22
Language：Japanese Presentation type：Symposium, workshop panel (public)
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Ｖｉｒｔｕａｌ Ｒｅａｌｉｔｙは外科教育を変えるか？：医学生に対する無菌手技および手術理解、心理状態に関する比較研究．
樋口和宏，甲斐健吾，濵田剛臣，七島篤志
第87回日本臨床外科学会学術集会
Event date： 2025.11.20 - 2025.11.22
Language：Japanese Presentation type：Oral presentation (general)
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当院で経験した痔瘻癌の3例.
市原明子，岩本和樹，原 大介，濵田朗子，山田和之介，武野慎祐，七島篤志
第80回日本大腸肛門病学会学術集会
Event date： 2025.11.14 - 2025.11.15
Language：Japanese Presentation type：Oral presentation (general)
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陰圧閉鎖療法により治療し得た鼠径部術後難治性リンパ漏の1例.
千代反田顕，樋口和宏，宗像 駿，池ノ上実，河野文彰，武野慎祐，七島篤志，藤田 環，伊東憲子，鬼頭雄也，伊東 大
第38回日本外科感染症学会
Event date： 2025.11.7 - 2025.11.8
Language：Japanese Presentation type：Oral presentation (general)
Works 【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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PDP効果に基づく胃癌腹膜播種に対する簡便かつ安全な光治療の開発
Grant number：24K11937 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Coinvestigator(s)
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GVHD誘導マウスでのサイトカイン阻害による胆道閉鎖症の炎症標的型治療法の開発
Grant number：23K08052 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
桝屋 隆太
Authorship：Coinvestigator(s)
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クリック反応技術と軸配位子糖鎖連結ポルフィリン錯体を融合した革新的PDTの開発
Grant number：22K08806 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
七島篤志
Authorship：Principal investigator
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FDG PET腫瘍診断と腫瘍遺伝子変異の関連に基づくテーラーメイド医療の開発
Grant number：26461857 2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
FDG PET腫瘍診断と腫瘍遺伝子変異の関連に基づくテーラーメイド医療の開発
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臨床実用を目指した癌幹細胞標的光線力学的療法の基礎研究
Grant number：26461045 2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
臨床実用を目指した癌幹細胞標的光線力学的療法の基礎研究