七島 篤志 (ナナシマ アツシ)

NANASHIMA Atsushi

写真a

所属

医学部 医学科 外科学講座肝胆膵外科学分野

職名

教授

外部リンク

関連SDGs


学位 【 表示 / 非表示

  • 医学博士 ( 1997年5月   長崎大学 )

研究分野 【 表示 / 非表示

  • ライフサイエンス / 外科学一般、小児外科学

  • ライフサイエンス / 消化器外科学

 

論文 【 表示 / 非表示

  • Surgical Outcomes and Diagnostic Concordance in Patients With Pancreatic Neuroendocrine Tumors Undergoing Pancreatectomy: A Retrospective Cohort Study. 査読あり

    Nanashima A, Hiyoshi M, Imamura N, Tsuchimochi Y, Wada T, Hamada T, Suzuki Y, Araki Y

    Cancer diagnosis & prognosis   6 ( 1 )   52 - 61   2026年1月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/cdp.10506

    PubMed

  • Comparison of postoperative results between types of pancreaticoenteral anastomosis after pancreaticoduodenectomy 査読あり

    Nanashima A., Arai J., Imamura N., Hiyoshi M., Tsuchimochi Y., Wada T., Hamada T.

    Gland Surgery   14 ( 12 )   2440 - 2455   2025年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Gland Surgery  

    Background: Pancreatic anastomosis has been developed, and each anastomosis has its pros and cons. This study investigated the prevalence of postoperative complications, particularly pancreatic fistula (POPF), among five types of pancreatoenteric anastomoses to determine the optimal anastomosis for patients undergoing pancreatectomy. Methods: This study retrospectively and consecutively analyzed the data of 365 patients who underwent pancreatectomy with pancreaticoenteral anastomosis at two academic institutions from 1994 to 2024. Pancreaticogastrostomy via invagination was performed in 24 patients (group PG). For pancreaticojejunal anastomosis, we performed an end-to-end invagination procedure on eight patients (group PJI), two-layer suturing procedure on 96 patients (group PJT), Kakita procedure on 55 patients (group K), and modified Blumgart procedure on 182 patients (group B). Results: Group B had the shortest hospital stay and fastest resumption of oral intake. Groups PG and PJI exhibited higher grade B/C POPF rates and prolonged ascites. The potential benefits of group B included reduced hospitalization period and enhanced recovery owing to decreased POPF rates. Habitual alcohol consumption and high preoperative creatinine levels increased the risk of POPF, whereas external drainage issues and blood loss contributed to prolonged ascites. In particular, habitual alcohol consumption [relative risk (RR) =2.42], group K anastomosis (RR =2.79), soft pancreatic texture (RR =2.48), delayed oral intake (≥4 days; RR =2.78), and complete external drainage (RR =8.68) were independent predictors of POPF. Conclusions: Modified Blumgart procedure is an optimal pancreaticoenteral anastomosis technique for avoiding POPF. Early oral intake has emerged as a protective factor, highlighting its role in improving postoperative outcomes. Surgeons should prioritize intraoperative blood conservation, perioperative nutritional support, and appropriate anastomotic selection to enhance surgical success.

    DOI: 10.21037/gs-2025-380

    Scopus

    PubMed

  • Managing uncontrolled bleeding in elective surgery: The role of damage control techniques 査読あり

    Nanashima A., Wada T., Kawano F., Hamada K., Taniguchi T., Furukawa K.

    International Journal of Surgery Case Reports   128   111040   2025年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Surgery Case Reports  

    Introduction: The main text introduction expands on the initial introduction by providing a more detailed discussion of massive bleeding in elective surgeries and its challenges. It describes how traditional hemostatic procedures are essential but may not always be sufficient, especially in uncontrolled coagulopathy despite aggressive transfusion. It then introduces DCS as a well-established approach in trauma surgery, emphasizing its role in stabilizing patients with hemorrhagic shock, coagulopathy, hypothermia, and acidosis. It highlights that DCS can be a lifesaving intervention when unexpected massive bleeding occurs and justifies its use in patients with unstable vital signs or increased intra-abdominal pressure by our two experienced cases presentation. Case 1. A 76-year-old obese male diagnosed with advanced transverse colon cancer with regional balky lymph node metastasis was identified at the root of the regional colic vein trunk. A robotic surgical approach was changed to open laparotomy because of bleeding tendency due to fatty mesentery. During the balky node dissection, the root of the vein was injured and induced massive bleeding during the compressive hemostatic procedure. As the hypotensive control rapidly became quite tricky, DCS by gauze packing and covered by the commercial dressing kit with open abdominal management (OAM). The second look operation, by supporting the Restrictive Endovascular Balloon Occlusion of the Aorta, repaired the superior mesenteric vein's injured parts. He survived for nine months. Case 2. The 72-year-old male patient was diagnosed as solitary 3 cm of hepatocellular carcinoma at S6 with alcoholic liver cirrhosis. The laparoscopic limited hepatic resection was changed to the open laparotomy due to the bleeding tendency at the transected parenchyma. After accomplishing limited resection, massive hepatic venous bleeding occurred; DCS was decided due to continuing hypotension, oozed hemorrhage, and low platelet level with metabolic acidosis by peri-hepatic gauze packing around the right liver. The second look operation for remnant hemostasis and the de-packing with abdominal closure could be achieved without severe events. The postoperative course showed no hepatic failure, and they recovered during a hospital stay. Discussion: It describes how conventional hemostatic procedures are essential but may not always be sufficient, especially in uncontrolled coagulopathy despite aggressive transfusion. DCS is a well-established approach in trauma surgery, emphasizing its role in stabilizing patients with hemorrhagic shock, coagulopathy, hypothermia, and acidosis. The role of DCS is well known even in elective surgery in unforeseen emergency situations such as hemodynamic instability, severe coagulopathy, and prolonged surgery over 24 h. It highlights that DCS can be a lifesaving intervention when unexpected massive bleeding occurs and justifies its use in patients with unstable vital signs or increased intra-abdominal pressure, where prolonged surgery is not feasible. It reinforces that DCS was successfully utilized in the reported cases, leading to favorable second-look operations. Conclusion: The main text introduction is a more comprehensive and structured expansion of the initial introduction. While the initial version introduces the problem concisely, the revised introduction elaborates on the challenges of massive bleeding, the principles of DCS, and its potential role in elective surgeries before transitioning into the case reports.

    DOI: 10.1016/j.ijscr.2025.111040

    Scopus

    PubMed

  • Clinical significance of para-aortic lymph node metastasis for prognosis in patients with pancreaticobiliary cancer who underwent radical surgical resections 査読あり

    Nanashima A., Arai J., Hiyoshi M., Imamura N., Hamada T., Tsuchimochi Y., Shimizu I., Ochiai T., Kawakami H., Sato Y., Takashi W.

    Turkish Journal of Surgery   41 ( 1 )   5 - 18   2025年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Turkish Journal of Surgery  

    Objective: To elucidate surgical strategies for patients undergoing radical resection, in cases where solitary distant lymph node metastasis is identified intraoperatively, we investigated the prognostic significance of para-aortic lymph node (PALN) metastases and other regional lymph node (RLN) metastases in pancreatic carcinomas (PC) and biliary duct cancers (BDC). Material and Methods: This study retrospectively analyzed data from 181 PC patients and 116 BDC patients who underwent radical resections at two institutions between 1994 and 2021. Results: Among PC patients, metastases were observed in RLN and PALN in 54% and 9% of cases, respectively. Similarly, RLN and PALN metastases were present among BDC patients in 39% and 9% of cases, respectively. Survival analysis revealed that patients with BDC and PALN metastases exhibited significantly reduced disease-free (DFS) and overall survival (OS) compared to those without PALN involvement. Multivariate analysis identified PALN metastasis as an independent predictor of OS in BDC patients (p<0.05), while RLN metastasis was independently associated with DFS (p<0.05). Additional clinicopathological factors associated with PALN and RLN metastases were also identified. Preoperative serum levels of Duke Pancreas II monoclonal antibody were significantly elevated in patients with PALN metastases. Histological findings of lymphatic or perineural infiltration and hepatic or pancreatic invasion were independently associated with RLN metastases. Conclusion: Based on these findings, radical resection may be considered for PC patients with isolated PALN metastases only in the absence of additional adverse prognostic factors. Prospective clinical trials are warranted to further refine the criteria for surgical intervention when solitary PALN metastases are detected intraoperatively.

    DOI: 10.47717/turkjsurg.2025.6587

    Scopus

    PubMed

  • Relationship between survival outcomes in patients with colorectal liver metastasis undergoing hepatectomy and significance of fibrotic markers for liver injury assessment 査読あり

    Nanashima A., Hiyoshi M., Imamura N., Hamada T., Tsuchimochi Y., Shimizu I., Ochiai T., Ichihara A., Hamada K., Ichiki N., Kai K., Higuchi K.

    Translational Cancer Research   14 ( 1 )   461 - 472   2025年1月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Translational Cancer Research  

    Background: Progression of chronic liver dysfunction influenced by long-term chemotherapy or repeated hepatectomy might be related to patient overall survival as well as tumor factors in colorectal liver metastasis (CLM) patients. Our aim of this study was to clarify the relationship between fibrotic liver damage and malignant behaviors of CLM malignancy or its long-term survivals by the retrospective cohort study. Methods: We examined the relationship between tumor-related factors or six liver fibrosis-associated parameters, including platelet count, hyaluronic acid (HA), mac-2 binding protein glycosylation isomer (M2BPGi), type IV collagen 7S (T4C7), aspartate aminotransferase-to-platelet ratio index (APRI), The fibrosis-4 (Fib-4) index, and clinicopathological parameters, surgical records, and postoperative patient survival in the 45 consecutive patients with CLM who underwent radical hepatectomy. Results: Fibrotic parameters were platelet count of 23.0±8.5 ×104/μL, HA level of 68.9±82.3 ng/mL, M2BPGi of 0.87±0.48 ng/mL, and type IV collagen level of 5.74±3.76 ng/mL. Platelet count was significantly correlated with HA level (P<0.05) and tended to be correlated with M2BPGi levels (P=0.056). HA level was significantly associated with albumin level (P<0.05). Overall survival in this series showed five-year overall survivors after hepatectomy in 44 patients (98%), but cancer-related deaths were observed in only one patient. Patients with higher grades and increased bilirubin levels demonstrated significantly lower cancer-free survival (P<0.05), but fibrotic parameters were not associated with prognostic factors. Conclusions: Fibrotic markers indicating chemotherapy or repeated surgical liver injury were not significant predictive factors reflecting cancer malignant behaviors or patient overall survival, contrary to our hypothesis. The current overall survival status using various modalities for cancer recurrence is satisfactory under our present perioperative management.

    DOI: 10.21037/tcr-24-1138

    Scopus

    PubMed

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書籍等出版物 【 表示 / 非表示

  • 消化器難治療癌シリーズV 肝細胞癌

    七島篤志( 担当: 共著 ,  範囲: おわりに)

    株式会社協和企画  2024年4月 

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    記述言語:日本語 著書種別:学術書

  • Therapeutic applications: Photodynamic therapy using porphyrin compounds

    Hamada T., Nanashima A.( 担当: 単著)

    Fluorescence-Guided Surgery: From Lab to Operation Room  2023年11月  ( ISBN:9789811973727, 9789811973710

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    記述言語:英語 著書種別:学術書

    As a result of recent advances in endoscopes and optical fibers, optical engineering has been introduced to medical treatment in these years. Photodynamic therapy (PDT) is a promising treatment method that irradiates a tumor with a highly tumor-accumulating photosensitive agent and a laser with a specific wavelength and shows a cell-killing effect only on tumor cells with high drug concentration. It has already been applied clinically in the fields of pulmonary and digestive surgery, neurosurgery, ophthalmology, dermatology, and urology. As described in other chapters, photodynamic diagnosis (PDD), which is a method to diagnose the localization of tumors by irradiating biological tissues with light and detecting the fluorescence generated by photosensitive agents accumulated in tumors, is also being actively studied and applied clinically.

    DOI: 10.1007/978-981-19-7372-7_33

    Scopus

  • 肝胆膵高難度外科手術[Web動画付]第3版

    旭吉雅秀,七島篤志( 担当: 共著 ,  範囲: 胆道再建)

    医学書院  2023年6月 

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    記述言語:日本語 著書種別:学術書

  • 術中イメージング実践ガイド -ラボからオペ室まで- 査読あり

    濵田剛臣,七島篤志( 担当: 共著 ,  範囲: Ⅲ術中蛍光イメージングの実際[開発編]: 4. 治療への応用(1): ポルフィリン化合物を用いた光線力学的治療)

    メジカルビュー  2020年9月  ( ISBN:978-4758315371

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    総ページ数:339   担当ページ:310-320   記述言語:日本語 著書種別:学術書

  • 新DS Now No.4 胆道癌・膵癌に対する標準手術−手技修得へのナビゲート− 査読あり

    長友謙三,濵田剛臣,七島篤志( 担当: 共著 ,  範囲: 膵体部癌に対する膵体尾部切除術)

    メジカルビュー社  2019年8月  ( ISBN:978-4-7583-1653-8

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    総ページ数:184   担当ページ:136-156   記述言語:日本語 著書種別:学術書

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MISC 【 表示 / 非表示

  • 論説 シン・私の考える~医学教育に使えた名言・格言〜Quotes and aphorisms that could be used in surgical and medical education

    七島篤志

    宮崎県医師会医学会誌   49 ( 2 )   117 - 123   2025年9月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

  • 地方都市施設におけるacute care surgeryのあり方とは?―当院の10年を振り返って見えてきた課題と対策―

    河野文彰,田代耕盛,池ノ上実,宗像 駿,鈴木康人,武野慎祐,古川貢之,落合秀信,七島篤志

    Japanese Journal of Acute Care Surgery   2025年4月

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    担当区分:最終著者   記述言語:日本語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: https://doi.org/10.50840/jjacs.15-1

  • 特集 臓器損傷治療の工夫【手術手技】腹部開放創陰圧治療法システムによるopen abdominal management 招待あり 査読あり

    桝屋隆太, 中目和彦, 宗像 駿, 河野文彰, 武野慎祐, 七島篤志, 家入里志

    小児外科   57 ( 2 )   231 - 235   2025年2月

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

    DOI: https://doi.org/10.24479/ps.0000001110

  • 【診療】鏡視下甲状腺手術の現状と課題 招待あり

    河野文彰,池ノ上実,宗像 駿,武野慎祐,七島篤志

    宮崎県医師会医学会誌   48 ( 1 )   42 - 47   2024年11月

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    担当区分:最終著者   記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

  • 特集【Acute Care Surgery入門-外傷対応の基礎知識】Open abdominal management-若手外科医が知っておくこと 招待あり 査読あり

    河野文彰,池ノ上実,宗像 駿,武野慎祐,七島篤志

    臨床外科   79 ( 4 )   395 - 402   2024年11月

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    担当区分:最終著者   記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

    DOI: https://doi.org/10.11477/mf.1407214736

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講演・口頭発表等 【 表示 / 非表示

  • Surgical Outcomes and Diagnostic Concordance in Patients With Pancreatic Neuroendocrine Tumors Undergoing Pancreatectomy: A Retrospective Cohort Study

    七島 篤志, 今村 直哉, 土持 有貴, 和田 敬, 濵田 剛臣, 鈴木 康人

    Cancer diagnosis & prognosis  2026年1月3日  International Institute of Anticancer Research

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    開催年月日: 2026年1月3日

    記述言語:英語   会議種別:口頭発表(一般)  

    Background/Aim Pancreatic neuroendocrine tumors (PanNETs) are heterogeneous neoplasms for which surgical resection remains the only potentially curative therapy. However, preoperative diagnostic accuracy - particularly tumor grading - often varies, complicating treatment decisions. This study evaluated diagnostic concordance between preoperative assessments and postoperative pathology, as well as surgical outcomes and prognostic factors in patients undergoing pancreatectomy for PanNETs. Patients and Methods We retrospectively reviewed the clinical records of 32 patients who underwent surgical resection for PanNETs. Patient demographics, tumor characteristics, surgical procedures, and postoperative outcomes were analyzed. Preoperative imaging and cytology-based diagnoses were compared with final pathological findings to evaluate diagnostic concordance. Prognostic factors were assessed using Kaplan-Meier survival analysis. Results Histological grading of resected specimens showed G1 in 53%, G2 in 41%, and G3/NEC in 6%, with a 38% discordance rate from preoperative biopsy. Lymphatic, venous, and perineural invasions were identified in 16%, 44%, and 13% of cases. Lymph node metastasis occurred in 22%. Among 30 patients with follow-up >12 months, eight developed recurrence, most commonly in the liver. The 3-year and 5-year disease-free survival (DFS) rates were 78% and 69%, while overall survival (OS) rates were 96% and 91%. Tumor number >2 and histologic grade G3 were significantly associated with reduced DFS (p<0.05). Lymphatic invasion and metachronous liver metastasis were significantly associated with reduced OS (p<0.01 and p<0.05, respectively). Histological grading mismatch was not associated with survival outcomes. Conclusion Pancreatectomy for PanNETs is a safe and effective treatment with favorable long-term outcomes. Histological factors such as tumor grade, lymphatic invasion, and tumor number significantly predict recurrence and survival.

    CiNii Research

  • Comparison of postoperative results between types of pancreaticoenteral anastomosis after pancreaticoduodenectomy

    七島 篤志, 今村 直哉, 土持 有貴, 和田 敬, 濵田 剛臣

    Gland Surgery  2025年12月31日  AME Publishing Company

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    開催年月日: 2025年12月31日

    記述言語:英語   会議種別:口頭発表(一般)  

    Background: Pancreatic anastomosis has been developed, and each anastomosis has its pros and cons. This study investigated the prevalence of postoperative complications, particularly pancreatic fistula (POPF), among five types of pancreatoenteric anastomoses to determine the optimal anastomosis for patients undergoing pancreatectomy. Methods: This study retrospectively and consecutively analyzed the data of 365 patients who underwent pancreatectomy with pancreaticoenteral anastomosis at two academic institutions from 1994 to 2024. Pancreaticogastrostomy via invagination was performed in 24 patients (group PG). For pancreaticojejunal anastomosis, we performed an end-to-end invagination procedure on eight patients (group PJI), two-layer suturing procedure on 96 patients (group PJT), Kakita procedure on 55 patients (group K), and modified Blumgart procedure on 182 patients (group B). Results: Group B had the shortest hospital stay and fastest resumption of oral intake. Groups PG and PJI exhibited higher grade B/C POPF rates and prolonged ascites. The potential benefits of group B included reduced hospitalization period and enhanced recovery owing to decreased POPF rates. Habitual alcohol consumption and high preoperative creatinine levels increased the risk of POPF, whereas external drainage issues and blood loss contributed to prolonged ascites. In particular, habitual alcohol consumption [relative risk (RR) =2.42], group K anastomosis (RR =2.79), soft pancreatic texture (RR =2.48), delayed oral intake (≥4 days; RR =2.78), and complete external drainage (RR =8.68) were independent predictors of POPF. Conclusions: Modified Blumgart procedure is an optimal pancreaticoenteral anastomosis technique for avoiding POPF. Early oral intake has emerged as a protective factor, highlighting its role in improving postoperative outcomes. Surgeons should prioritize intraoperative blood conservation, perioperative nutritional support, and appropriate anastomotic selection to enhance surgical success.

    CiNii Research

  • Outcomes of Resected Cases of Pancreatic Ductal Adenocarcinoma Patients With Unexpected Postoperative Uncovering Noncurative Factors: A Multicenter Retrospective Study

    七島 篤志

    Annals of Gastroenterological Surgery  2025年9月9日  Wiley

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    開催年月日: 2025年9月9日

    記述言語:英語   会議種別:口頭発表(一般)  

    Aim We aimed to refine treatment strategies for resected cases of pancreatic ductal adenocarcinoma in patients with unexpectedly uncovered postoperative noncurative factors while also evaluating the effectiveness of neoadjuvant and adjuvant chemotherapy. Methods We retrospectively analyzed clinicopathological and follow-up data from 1068 PDAC patients who underwent surgical resection at 13 Kyushu Study Group institutions (January 2016–December 2020). Patients were categorized into two groups: without (Group A) or with (Group B) unexpected postoperative noncurative factors. Kaplan–Meier analysis assessed disease-free and overall survival, while univariate and multivariate analyses using the Cox proportional hazards model identified prognostic factors. Results Group B (n = 44) had poorer survival than Group A (n = 981) (16.8 vs. 38.6 months; p < 0.001). The noncurative factors were associated with poor disease-free survival (hazard ratio, 1.544; 95% confidence interval, 1.067–2.179; p = 0.022) but not overall survival (hazard ratio, 1.332; 95% confidence interval, 0.910–1.950; p = 0.140). In Group B, patients receiving adjuvant chemotherapy had better disease-free survival (6.8 months vs. 3.4 months; p = 0.092), However, no significant difference was observed in overall survival. Furthermore, patients in Group B who received adjuvant chemotherapy had a worse prognosis compared to both Group A patients who received chemotherapy and those who did not. Preoperative therapy did not improve disease-free survival or overall survival in cases with postoperative noncurative factors. Conclusion Cases with noncurative factors had significantly poorer prognoses than those without. In the present study, effective adjuvant chemotherapy for these patients could not be demonstrated. Therefore, thorough preoperative and intraoperative evaluation of noncurative factors is crucial to prevent futile surgery.

    CiNii Research

  • 切除不能進行食道神経内分泌癌に対するCRT完全奏効後の扁平上皮癌へPDT後にサルベージ手術を施行した1例

    荒木 裕介, 武野 慎祐, 池ノ上 実, 田代 耕盛, 河野 文彰, 落合 貴裕, 清水 一晃, 千代反田 顕, 田平 康晴, 大田 勇輔, 中島 孝治, 七島 篤志

    日本気管食道科学会会報  2025年6月10日  特定非営利活動法人 日本気管食道科学会

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    開催年月日: 2025年6月10日

    記述言語:英語   会議種別:口頭発表(一般)  

    症例は71歳の女性。嗄声と嚥下障害を主訴に前医を受診し,切歯から27-30 cmの食道に気管浸潤を伴う食道神経内分泌癌を認め,化学放射線療法(CRT)が行われた。18コース施行後の上部消化管内視鏡検査で,切歯から25,26,38 cmの食道に扁平上皮癌を認め,神経内分泌癌は認められなかった。同部位に光線力学的療法を2回施行したが,切歯から38 cmの病変に腫瘍が残存していたため,外科的切除の方針とした。周囲組織との強い癒着が予想されたため,Ivor-Lewis法が選択された。術中所見として,食道壁の浮腫と瘢痕がみられ,視野が困難となり,開胸へ移行した。患者は術後ICUに入室し,POD7より経口摂取を開始し,経過良好でPOD23に退院した。食道神経内分泌癌は組織学的悪性度が高く,予後不良で比較的稀な食道悪性腫瘍である。内視鏡的切除や外科的切除が考慮されるが,進行期で発見されることが多く,放射線療法や化学療法が推奨され,再発率は比較的高い。今回,食道神経内分泌癌に対するCRT完全奏効後の扁平上皮癌に対してサルベージ手術を施行した1例を経験したため報告する。

    CiNii Research

  • 術前に膵頭部癌と診断した遠位胆管癌の特徴

    旭吉 雅秀, 七島 篤志, 佐藤 勇一郎

    胆道  2025年5月31日  一般社団法人 日本胆道学会

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    開催年月日: 2025年5月31日

    記述言語:日本語   会議種別:口頭発表(一般)  

    膵頭部に腫瘤を形成して術前に膵頭部癌と診断した遠位胆管癌症例(Pre-Pancreatic ductal adenocarcinoma:Pre-PDAC群)について,通常の遠位胆管癌(Bile duct cancer:BDC群)との相違を膵頭部癌を含めて検討した.69例の遠位胆管癌中,54例(78.3%)に根治切除として膵頭十二指腸切除術を施行した.切除症例の中でPre-PDAC症例は9例(16.7%)あり,その生存期間中央値は20.9カ月で,BDC群の106.8カ月と比較して不良であり,非切除症例の12.0カ月,膵頭部癌症例の32.9カ月と変わらなかった.2年の無再発生存割合は,BDC群の60.0%に対して,Pre-PDAC群は25.0%と有意に低下しており,肝転移再発を多く認めた.

    CiNii Research

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Works(作品等) 【 表示 / 非表示

  • 新しい肝がんの腫瘍マーカー

    2011年

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    作品分類:芸術活動  

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科研費(文科省・学振・厚労省)獲得実績 【 表示 / 非表示

  • PDP効果に基づく胃癌腹膜播種に対する簡便かつ安全な光治療の開発

    研究課題/領域番号:24K11937  2024年04月 - 2027年03月

    独立行政法人日本学術振興会  科学研究費基金  基盤研究(C)

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    担当区分:研究分担者 

  • GVHD誘導マウスでのサイトカイン阻害による胆道閉鎖症の炎症標的型治療法の開発

    研究課題/領域番号:23K08052  2023年04月 - 2026年03月

    独立行政法人日本学術振興会  科学研究費基金  基盤研究(C)

    桝屋 隆太

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    担当区分:研究分担者 

  • クリック反応技術と軸配位子糖鎖連結ポルフィリン錯体を融合した革新的PDTの開発

    研究課題/領域番号:22K08806  2022年04月 - 2025年03月

    独立行政法人日本学術振興会  科学研究費基金  基盤研究(C)

    七島篤志

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    担当区分:研究代表者 

  • FDG PET腫瘍診断と腫瘍遺伝子変異の関連に基づくテーラーメイド医療の開発

    研究課題/領域番号:26461857  2014年04月 - 2017年03月

    科学研究費補助金  基盤研究(C)

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    担当区分:研究分担者 

    FDG PET腫瘍診断と腫瘍遺伝子変異の関連に基づくテーラーメイド医療の開発

  • 臨床実用を目指した癌幹細胞標的光線力学的療法の基礎研究

    研究課題/領域番号:26461045  2014年04月 - 2017年03月

    科学研究費補助金  基盤研究(C)

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    担当区分:研究分担者 

    臨床実用を目指した癌幹細胞標的光線力学的療法の基礎研究

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その他競争的資金獲得実績 【 表示 / 非表示

  • 胆管癌治療を目的としたレザフィリンを用いた光線力学的療法の開発研究

    2019年01月 - 2021年12月

    一般財団法人 日本消化器病学会  臨床研究助成金 

    七島篤志

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    担当区分:研究代表者 

  • 切除不能胆管癌における内視鏡を用いた光線力学療法の安全性と有用性に関する臨床試験

    2018年03月

    民間財団等  内視鏡医学研究振興財団研究助成金 

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    資金種別:競争的資金

寄附金・講座・研究部門 【 表示 / 非表示

  • 外科学講座肝胆膵外科学・消化管、内分泌、小児外科学分野研究奨学金

     2025年03月

  • 外科学講座肝胆膵外科学・消化管、内分泌、小児外科学分野研究奨学金

     2025年01月

  • 外科学講座肝胆膵外科学・消化管、内分泌、小児外科学分野研究奨学金

     2024年10月

  • 外科学講座肝胆膵外科学・消化管、内分泌、小児外科学分野研究奨学金

     2024年07月

  • 外科学講座肝胆膵外科学・消化管、内分泌、小児外科学分野研究奨学金

     2024年07月

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授業 【 表示 / 非表示

  • 環境と生命

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    科目区分:共通教育科目