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Affiliation |
Faculty of Medicine School of Medicine Department of Medicine of Sensory and Motor Organs, Oral and Maxillofacial Surgery |
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KANEUJI Takeshi
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Degree 【 display / non-display 】
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Doctor(Dental) ( 2011.3 Kyushu Dental College )
Research Areas 【 display / non-display 】
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Life Science / Surgical dentistry
Papers 【 display / non-display 】
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Yamaguma Y., Kaneuji T., Shirouzu S., Kubota T., Fukui T., Nakamura Y., Tanaka F., Hirayama B., Nagata J., Yamashita Y.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 35 ( 3 ) 241 - 243 2023.5
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Although surgical resection is the mainstay of treatment for lip cancer, reconstruction of the tissue defect after lip cancer resection must take into consideration not only lip function, but also the patient's appearance. However, there is no standard recommendation regarding the reconstruction method. We describe here a case in which we achieved good functional and esthetic results using a tongue flap and V-Y advancement flap for reconstruction of the tissue defect resulting from resection of lower lip cancer. This reconstruction method is simple and might become one of the treatment options for lower lip reconstruction.
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Decreased prostasin expression is associated with aggressiveness of oral squamous cell carcinoma
Yamamoto K., Yamashita F., Kawaguchi M., Izumi A., Kiwaki T., Kataoka H., Kaneuji T., Yamashita Y., Fukushima T.
Human Cell 34 ( 5 ) 1434 - 1445 2021.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Human Cell
Prostasin is a glycosylphosphatidylinositol-anchored serine protease widely expressed in epithelial cells, with crucial epidermal barrier functions. Evidence has suggested prostasin may have served as a tumor suppressor in various cancers, but its role in oral squamous cell carcinoma (OSCC) remains unclear. Thus, herein, we conducted an immunohistochemical prostasin study in 119 resected OSCC cases. Prostasin expression was decreased in 63% (75/119) of cases. OSCC with decreased prostasin immunoreactivity (low prostasin cases) tended to show a higher histological grade (p = 0.0088) and a more infiltrative cancer cell morphology (p = 0.0024). We then explored the role of prostasin in the OSCC cell lines: SAS and HSC-4. SAS did not express detectable prostasin levels, whereas HSC-4 expressed low but distinct levels. Prostasin overexpression suppressed the proliferation and migration of both OSCC lines in vitro. Conversely, prostasin silencing significantly enhanced growth rates of HSC-4. Finally, we analyzed the impact of prostasin expression on the prognosis of patients with OSCC; decreased expression tended to correlate with shorter overall survival (p = 0.0291) after resection. This trend was supported by our analyses using a public database (Kaplan–Meier plotter) of head and neck squamous cell carcinomas. In conclusion, we showed decreased prostasin expression was associated with aggressive features and a poorer prognosis of OSCC.
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Kiyomiya H., Nogami S., Yoshiga D., Miyamoto I., Ichimiya H., Tanaka K., Kaneuji T., Yamauchi K., Yamashita Y., Takahashi T.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 32 ( 5 ) 370 - 376 2020.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Maxillofacial trauma that occurs in a traffic accident often results in not only missing teeth but also sever bone defects, with bone augmentation including possible reconstruction of occlusion needed for treatment. This case report describes bone augmentation treatment for a patient with severe bone injuries because of a traffic accident, in which titanium mesh and an iliac bone (autogenous particulate cancellous bone and marrow: PCBM) graft were utilized. A 33-year-old male was involved in a traffic accident and referred to visited Kyushu Dental University Hospital 2 months later. Computerized tomographic scanning showed a maxillary and mandibular anterior alveolar bone defects. Mandibular surgery was performed under general anesthesia, and a reconstructive plate was used for fixation with titanium mesh as well as PCBM graft. For the alveolar bone defect in the maxillary anterior region, bone augmentation using titanium mesh was also performed. At 6 months after the operation, the plate and titanium mesh were removed, then 5 implants were successfully placed and remained intact for more than 5 years. Additionally, the esthetic and functional results successfully matched the expectations of the patients.
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Amelioration of limited mouth opening after treatment of primary biliary cholangitis: A case report Reviewed
Kaneuji T., Yoshiga D., Ariyoshi W., Nakamichi I., Tanimoto H., Tanaka J., Miyamoto I., Habu M., Mitsugi S., Nishihara T., Takahashi T., Tominaga K., Yoshioka I.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2019.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
© 2019 Asian AOMS(+)ASOMP(+)JSOP(+)JSOMS(+)JSOM(+)and JAMI Primary biliary cholangitis is a slow-progressing autoimmune disease of the liver characterized by the presence of portal inflammation and immune-mediated destruction of the intrahepatic bile ducts. Herein, we report a case of temporomandibular joint disorder that concurred with primary biliary cholangitis. A 54-year-old woman presented to us with severe pain on the left side of the temporomandibular joint and difficulty in mouth opening. We used pharmacotherapy, occlusal sprint, and arthrocentesis for the treatment; however, there was no improvement. Magnetic resonance imaging revealed malposition of the articular disk on the left side of the joint and joint effusion. Thus, we performed arthroscopic surgery under general anesthesia. Postoperatively, she developed impaired liver function and itchiness of the skin. A liver biopsy was performed by a hepatologist, and a diagnosis of primary biliary cholangitis was made, as suspected. The temporomandibular joint pain and trismus persisted postoperatively; however, these symptoms improved after primary biliary cholangitis therapy. Thus, we suggest a relationship between temporomandibular joint disorder and primary biliary cholangitis from this disease trajectory and suspect that interleukin-17 may play an important role in the pathogenesis of temporomandibular joint disorder.
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Amelioration of limited mouth opening after treatment of primary biliary cholangitis: A case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. Reviewed
Kaneuji T, Yoshiga D, Ariyoshi W, Nakamichi I, Tanimoto H, Tanaka J,, Miyamoto I, Habu M, Mitsugi S, Nishihara T, Takahashi T, Tominaga K, Yoshioka I
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2019.9
Language：English Publishing type：Research paper (scientific journal)
MISC 【 display / non-display 】
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Yamaguma Y., Kaneuji T., Shirouzu S., Fukui T., Nakamura Y., Hirayama B., Kiyomiya H., Nagata J., Yamashita Y.
Oral Oncology 127 105817 2022.4
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Oral Oncology
Although Mohs paste can control bleeding, exudates, and odors from tumors, there have been no reports of the combination of Mohs paste with other treatments, such as chemotherapy, in oral cancer. Here, we report the combination of Mohs paste and chemotherapy for a case of metastatic oral cancer to the precordium skin and bilateral axillary lymph nodes. The tumors almost completely disappeared after the treatment. Combination therapy of Mohs paste and chemotherapy appears to have a better antitumor effect than Mohs paste alone.
Presentations 【 display / non-display 】
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口腔顎顔面領域における内視鏡を用いた低侵襲外科手術について Invited
金氏 毅
第84回日本口腔外科学会総会・学術大会
Event date： 2019.10.26 - 2019.10.28
Language：Japanese Presentation type：Oral presentation (invited, special)
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重度心身障害者の下顎に生じた巨大嚢胞に対して低侵襲治療を応用した１例
金氏 毅，近藤雄大，山下善弘
第12回日本口腔検査学会・第30回日本臨床口腔病理学会・第29回日本口腔内科学会・第32回日本口腔診断学会合同学術大会
Event date： 2019.9.21 - 2019.9.23
Language：Japanese Presentation type：Oral presentation (general)
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当院における下顎関節突起骨折の臨床的検討
金氏 毅，永田順子，山下善弘
第32回日本顎関節学会総会
Event date： 2019.7.27 - 2019.7.28
Language：Japanese Presentation type：Poster presentation
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Effect of positional change of proximal segment on postoperative stability after sagittal split ramus osteotomy International conference
Takeshi Kaneuji, Yoshihiro Yamashita
24th Congress of the European Association for Cranio Maxillo Facial Surgery
Event date： 2018.9.18 - 2018.9.21
Language：English Presentation type：Poster presentation
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人工呼吸器管理患者に対する濁度計を用いた口腔清潔度評価の有用性
金氏 毅，井川加織，近藤雄大，山下善弘
第28回日本口腔内科学会・第31回日本口腔診断学会学術大会
Event date： 2018.9.14 - 2018.9.15
Language：Japanese Presentation type：Poster presentation
Awards 【 display / non-display 】
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第28回日本口腔内科学会・第31回日本口腔診断学会学術大会優秀ポスター賞
2018.9 日本口腔内科学会，日本口腔診断学会 人工呼吸器管理患者に対する濁度計を用いた口腔清潔度評価の有用性
金氏毅,井川加織,近藤雄大,山下善弘
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第55回日本口腔外科学会総会優秀ポスター賞
2011.10 日本口腔外科学会 メカニカルストレスが及ぼす骨芽細胞による破骨細胞誘導系への影響について
金氏毅,三次翔,高橋哲
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第56回日本口腔外科学会総会優秀ポスター賞
2011.10 日本口腔外科学会 メカニカルストレスが加えられた骨芽細胞を介した破骨細胞分化誘導の制御機構について
金氏毅,高橋哲
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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骨芽細胞由来液性因子によるオーダーメイド骨再生医療のための基盤形成
Grant number：17K17278 2017.04 - 2019.03
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
骨芽細胞系細胞に圧縮刺激を加えて得られた培養上清（MsCM-OB）の骨形成・骨再生における作用を検討し、骨再生医療への応用を目指す。申請者はこれまでに予備的研究からMsCM-OBに含まれる液性因子が骨形成を促進する可能性を見出している。そこで本研究では、骨折モデルマウスならびに頭蓋骨欠損モデルマウスにMsCM-OBを局所投与し、骨折治癒や骨欠損修復に対するMsCM-OBの作用を検証する。そして将来的に、例えば“患者から樹立されたiPS細胞から骨芽細胞を分化させ、機械的圧力を加えて培養上清（MsCM-OB）を回収し、骨欠損部に局所投与する”といった患者由来の液性因子を用いた副作用の少ないオーダーメイドの顎骨再生医療が実現するための基盤を形成する。