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医学部 医学科 感覚運動医学講座顎顔面口腔外科学分野 |
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講師 |
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Myxolipoma in the buccal region: A case report and review of literature 査読あり
Baba T., Baba H., Fukui T., Kaneuji T., Kashima K., Yamashita Y.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 37 ( 3 ) 594 - 598 2025年5月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Lipomas are benign mesenchymal tumors with a relatively high incidence rate. However, myxolipomas, a histological variant characterized by mature adipose tissue and abundant myxoid substances, are rare, especially in the oral cavity. This case report focuses on a 90-year-old-female patient, the oldest reported with oral myxolipoma, who presented with the chief complaint of a painless mass in her right buccal region that had persisted for several years. The mass (approximately 25 mm in diameter) was palpable, soft, elastic, and covered with normal mucosa. In general, the Hounsfield unit (HU) of lipomas is approximately –100 units on computed tomography, and lipomas show high signal intensity on both T1- and T2-weighted magnetic resonance imaging. In contrast, in this case, the HU was approximately 50 units, which is slightly lower than that of the common muscle, similar to a previous report on myxomas. Unlike common lipomas, the present case exhibited low and high signal intensities on T1- and T2-weighted images, respectively. The tumor was surgically excised under local anesthesia and histopathological examination revealed a well-defined lobulated mass surrounded by a thin fibrous capsule. The tumor cells exhibited a solid proliferation of mature adipocytes, which were replaced by abundant myxoid substances. Based on these findings, the patient was diagnosed with a myxolipoma. Myxolipoma should be considered as a differential diagnosis when myxomas are suspected on preoperative imaging studies. The postoperative follow-up was uneventful, and no evidence of recurrence was observed 2 years postoperatively.
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Chondrolipoma arising in the tongue and related literature review: A report of two cases 査読あり
Baba T., Yamaguma Y., Fukui T., Kaneuji T., Kashima K., Yamashita Y.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 37 ( 2 ) 391 - 395 2025年3月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Chondrolipomas are rare benign tumors composed of mature adipocytes, a metaplastic chondromatrix, and cartilaginous chondrocytes. Herein, we present two cases of chondrolipoma of the tongue. The first case involved a 62-year-old woman who had a painless mass on the border of her tongue for four years; the second patient was a 74-year-old woman with a painless mass on the dorsal aspect of her tongue that had persisted for approximately six decades. Both cases were clinically diagnosed as benign tumors and the patients underwent surgical excision under general anesthesia. No local recurrence was observed during their 5-year postoperative follow-up periods. We further investigated 19 cases of chondrolipoma arising in the lip and oral cavity, including 17 previously reported cases and the two presented cases. The cartilage found in these tumors likely represents metaplastic changes or hamartomatous proliferation, attributed to the multipotentiality of mesenchymal stem cells.
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Shirakawa J., Kaneuji T., Matsuno D., Nagata J., Hirayama B., Tanaka F., Nakamura Y., Yamashita Y.
Journal of Stomatology, Oral and Maxillofacial Surgery 125 ( 4 ) 101907 2024年9月
担当区分：責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Stomatology, Oral and Maxillofacial Surgery
Introduction: The extent of surgical resection for tongue tumors is determined by tumor size, potentially affecting oral function and quality of life (QoL). However, the relationship between oral dysfunction and QoL decline due to glossectomy extent remains unexplored. Therefore, these correlations and their predictive value for postoperative QoL decline were elucidated. Methods: Patients treated for tongue cancer at our hospital between 2018 and 2022 were categorized by partial, hemi, or subtotal/total glossectomy. Assessments included swallowing function (RSST), articulation (Oral Diadochokinesis (ODK)), mastication, tongue pressure, and oral moisture. QoL was measured using the Oral Health Impact Profile-14 (OHIP-14). Differences within parameters were assessed using Kruskal–Wallis tests, and between-group comparisons via Mann–Whitney U tests. Spearman's correlation analysis examined parameter relationship. Results: 35 patients were evaluated. Significant differences were found in ODK [ta] (p = 0.015), [ka] (p = 0.0006), tongue pressure (p = 0.0001), moisture levels (p = 0.031), OHIP-14 domains: physical disability (p = 0.014) and social disability (p = 0.046). ODK [ta] (PG: 5.95, HG: 5.38, TG: 4.03 times), [ka] (PG: 5.56, HG: 4.78, TG: 3.23 times), and tongue pressure (PG: 32.9, HG: 21.2, TG: 10.3 mmHg) decreased with glossectomy extent, while physical (PG: 0.27, HG: 2.38, TG: 2.00) and social disability (PG: 0.18, HG: 0.94, TG: 1.43) worsened. A significant negative correlation was observed between tongue pressure and social disability (p = 0.013, r = -0.36). Conclusion: Expanding resection significantly impacted postoperative oral function and QoL. Tongue pressure assessment may predict long-term social disability in patient QoL.
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NAB2-STAT6 融合遺伝子の発現を認め中等度の転移リスクが示唆された上顎孤立性線維腫の1例
馬場 貴, 山本 哲彰, 鹿嶋 光司, 福井 丈仁, 金氏 毅, 山下 善弘
日本口腔外科学会雑誌 70 ( 3 ) 134 - 140 2024年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本口腔外科学会
Solitary fibrous tumor（SFT） is a rare tumor in the oral region, and NAB2-STAT6 gene fusions are pathognomonic for SFT. Recently, various NAB2-STAT6 genotypes have been confirmed. This paper describes a case of a histologically rare metastasis of SFT with intermediate malignant potential that occurred in the maxillary gingiva. A 96-year-old woman visited our hospital because of swelling of the upper gingiva. Intra-oral examination revealed a well-defined elastic hard mass measuring 20×15×15 mm in the maxillary tuberosity. After several imaging examinations, a clinical diagnosis of benign tumor in the upper jaw was suggested. The lesion was surgically excised. Histological examination showed randomly arranged short spindle-shaped cells with indistinct, pale eosinophilic cytoplasm within a variably collagenous stroma, nuclear atypia, and five mitoses in ten high power fields. Immunohistochemical examination showed positive for STAT6, CD34, and CD99, and Ki-67 labeling index was 15%. The patient was considered to be at intermediate risk according to the 3-variable model for the prediction of metastatic risk. Genetic analysis showed NAB2 exon6-STAT6 exon 17 fusion gene. The histological diagnosis was SFT indicating intermediate malignant potential, but with intermediate risk of metastasis. No recurrence or metastasis have been observed in the five years following surgery.
DOI： 10.5794/jjoms.70.134
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Kouketsu A., Kaneuji T., Yamaguma Y., Yamauchi K., Sugiura T., Takahashi T., Ito H., Yamashita Y.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 137 ( 1 ) 6 - 11 2024年1月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Objective: Flap complications continue to be a challenge in microsurgical reconstruction for older adults. We aimed to evaluate the impact of age on surgical outcomes after microvascular reconstruction. Study Design: We retrospectively investigated 103 patients with oral squamous cell carcinoma who had undergone microvascular reconstruction surgery to compare microsurgical reconstruction, common postoperative complications, and flap success rates in geriatric (>75 years) and non-geriatric (<75 years) patients. We also evaluated differences based on the American Society of Anesthesiologists Physical Status score. Results: We found no significant differences between the geriatric and non-geriatric groups in peri-operative, postoperative, or general complications. Conversely, we found that delirium and aspiration pneumonia were significantly more likely to occur in geriatric patients and that multiple medical complications were significantly more likely to occur in geriatric patients with a high American Society of Anesthesiologists score. Conclusion: Microvascular reconstruction can be performed effectively and without excessive complications in geriatric patients, and age should not be considered a contraindication for this procedure. Comorbidities play a stronger role in the prediction of adverse events.
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Yamaguma Y., Kaneuji T., Shirouzu S., Fukui T., Nakamura Y., Hirayama B., Kiyomiya H., Nagata J., Yamashita Y.
Oral Oncology 127 105817 2022年4月
記述言語：日本語 掲載種別：速報，短報，研究ノート等（学術雑誌） 出版者・発行元：Oral Oncology
Although Mohs paste can control bleeding, exudates, and odors from tumors, there have been no reports of the combination of Mohs paste with other treatments, such as chemotherapy, in oral cancer. Here, we report the combination of Mohs paste and chemotherapy for a case of metastatic oral cancer to the precordium skin and bilateral axillary lymph nodes. The tumors almost completely disappeared after the treatment. Combination therapy of Mohs paste and chemotherapy appears to have a better antitumor effect than Mohs paste alone.
講演・口頭発表等 【 表示 ／ 非表示 】
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口腔顎顔面領域における内視鏡を用いた低侵襲外科手術について 招待あり
金氏 毅
第84回日本口腔外科学会総会・学術大会
開催年月日： 2019年10月26日 - 2019年10月28日
記述言語：日本語 会議種別：口頭発表（招待・特別）
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重度心身障害者の下顎に生じた巨大嚢胞に対して低侵襲治療を応用した１例
金氏 毅，近藤雄大，山下善弘
第12回日本口腔検査学会・第30回日本臨床口腔病理学会・第29回日本口腔内科学会・第32回日本口腔診断学会合同学術大会
開催年月日： 2019年9月21日 - 2019年9月23日
記述言語：日本語 会議種別：口頭発表（一般）
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当院における下顎関節突起骨折の臨床的検討
金氏 毅，永田順子，山下善弘
第32回日本顎関節学会総会
開催年月日： 2019年7月27日 - 2019年7月28日
記述言語：日本語 会議種別：ポスター発表
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Effect of positional change of proximal segment on postoperative stability after sagittal split ramus osteotomy 国際会議
Takeshi Kaneuji, Yoshihiro Yamashita
24th Congress of the European Association for Cranio Maxillo Facial Surgery
開催年月日： 2018年9月18日 - 2018年9月21日
記述言語：英語 会議種別：ポスター発表
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人工呼吸器管理患者に対する濁度計を用いた口腔清潔度評価の有用性
金氏 毅，井川加織，近藤雄大，山下善弘
第28回日本口腔内科学会・第31回日本口腔診断学会学術大会
開催年月日： 2018年9月14日 - 2018年9月15日
記述言語：日本語 会議種別：ポスター発表
受賞 【 表示 ／ 非表示 】
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第28回日本口腔内科学会・第31回日本口腔診断学会学術大会優秀ポスター賞
2018年9月 日本口腔内科学会，日本口腔診断学会 人工呼吸器管理患者に対する濁度計を用いた口腔清潔度評価の有用性
金氏毅,井川加織,近藤雄大,山下善弘
受賞区分：国内学会・会議・シンポジウム等の賞 受賞国：日本国
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第55回日本口腔外科学会総会優秀ポスター賞
2011年10月 日本口腔外科学会 メカニカルストレスが及ぼす骨芽細胞による破骨細胞誘導系への影響について
金氏毅,三次翔,高橋哲
受賞区分：国内学会・会議・シンポジウム等の賞 受賞国：日本国
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第56回日本口腔外科学会総会優秀ポスター賞
2011年10月 日本口腔外科学会 メカニカルストレスが加えられた骨芽細胞を介した破骨細胞分化誘導の制御機構について
金氏毅,高橋哲
受賞区分：国内学会・会議・シンポジウム等の賞 受賞国：日本国
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
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骨芽細胞由来液性因子によるオーダーメイド骨再生医療のための基盤形成
研究課題/領域番号：17K17278 2017年04月 - 2019年03月
科学研究費補助金 若手研究(B)
担当区分：研究代表者
骨芽細胞系細胞に圧縮刺激を加えて得られた培養上清（MsCM-OB）の骨形成・骨再生における作用を検討し、骨再生医療への応用を目指す。申請者はこれまでに予備的研究からMsCM-OBに含まれる液性因子が骨形成を促進する可能性を見出している。そこで本研究では、骨折モデルマウスならびに頭蓋骨欠損モデルマウスにMsCM-OBを局所投与し、骨折治癒や骨欠損修復に対するMsCM-OBの作用を検証する。そして将来的に、例えば“患者から樹立されたiPS細胞から骨芽細胞を分化させ、機械的圧力を加えて培養上清（MsCM-OB）を回収し、骨欠損部に局所投与する”といった患者由来の液性因子を用いた副作用の少ないオーダーメイドの顎骨再生医療が実現するための基盤を形成する。