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Faculty of Medicine School of Medicine Department of Infectious Diseases, Microbiology |
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Research Areas 【 display / non-display 】
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Life Science / Anatomy and histopathology of nervous system
Papers 【 display / non-display 】
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Administration of L-Type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential Reviewed International journal
Morikazu Imamura, Ken'ichi Hagiwara, Minoru Tobiume, Minako Ohno, Hiromi Iguchi, Hanae Takatsuki, Tsuyoshi Mori, Ryuichiro Atarashi, Hiroaki Shibata, Fumiko Ono
Emerg Infect Dis. 31 ( 5 ) 986 - 990 2025.5
Language:English Publishing type:Research paper (scientific journal) Publisher:CDC
We administered L-type bovine spongiform encephalopathy prions to macaques to determine their potential for transmission to humans. After 75 months, no clinical symptoms appeared, and prions were undetectable in any tissue by Western blot or immunohistochemistry. Protein misfolding cyclic amplification, however, revealed prions in the nerve and lymphoid tissues.
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Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures. Reviewed
Takatsuki H, Imamura M, Mori T, Atarashi R
Sci Rep 12 ( 1 ) 7923 2022.5
Authorship:Last author, Corresponding author Language:English Publishing type:Research paper (scientific journal)
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Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system. Reviewed
Imamura M, Tabeta N, Iwamaru Y, Takatsuki H, Mori T, Atarashi R
Biochem Biophys Res Commun 613 67 - 72 2022.5
Authorship:Last author, Corresponding author Language:English Publishing type:Research paper (scientific journal)
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Discrimination between L-type and C-type bovine spongiform encephalopathy by the strain-specific reactions of real-time quaking-induced conversion. Reviewed
Ubagai K, Fukuda S, Mori T, Takatsuki H, Taguchi Y, Kageyama S, Nishida N, Atarashi R
Biochem Biophys Res Commun 526 ( 4 ) 1049 - 1053 2020.6
Authorship:Last author, Corresponding author Language:English Publishing type:Research paper (scientific journal)
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Identification of alprenolol hydrochloride as an anti-prion compound using surface plasmon resonance imaging. Reviewed
Miyazaki Y, Ishikawa T, Kamatari YO, Nakagaki T, Takatsuki H, Ishibashi D, Kuwata K, Nishida N, Atarashi R
Mol Neurobiol 56 ( 1 ) 367 - 377 2019.1
Authorship:Last author, Corresponding author Language:English Publishing type:Research paper (scientific journal)
Books 【 display / non-display 】
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標準微生物学 第14版
新竜一郎( Role: Joint author , ピコルナウイルス科(第34章プラス鎖RNAウイルス))
医学書院 2021.3
Total pages:690 Responsible for pages:425-431 Language:Japanese Book type:Scholarly book
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標準微生物学 第13版
新竜一郎( Role: Joint author , ピコルナウイルス科(第34章プラス鎖RNA型ウイルス))
医学書院 2018.3
Total pages:663 Responsible for pages:403-411 Language:Japanese Book type:Scholarly book
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Annual Review神経
新竜一郎, 佐藤克也( Role: Joint author , プリオン病の髄液診断の可能性)
中外医学社 2011.1
Language:Japanese Book type:Scholarly book
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モデル動物の作成と維持
新竜一郎, 片峰茂( Role: Joint author , 第3節感染・免疫 第1項プリオン病)
エル・アイ・シー 2004.7
Language:Japanese Book type:Scholarly book
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実験医学
中桶了太, 新竜一郎, 片峰茂( Role: Joint author , ジーンターゲッティングの実際・PrP遺伝子)
羊土社 1996.12
Language:Japanese Book type:Scholarly book
MISC 【 display / non-display 】
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異常型プリオンタンパク質の高感度増幅技術とその応用 Invited
新竜一郎
ファルマシア 62 ( 2 ) 112 - 115 2026.2
Authorship:Lead author, Last author, Corresponding author Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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RT‑QuIC as ultrasensitive method for prion detection. Invited Reviewed
Atarashi Ryuichiro
Cell Tissue Res 392 ( 1 ) 295 - 300 2022.1
Authorship:Lead author, Corresponding author Language:English Publishing type:Article, review, commentary, editorial, etc. (scientific journal)
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バキュロウイルス-昆虫細胞発現組換えPrP を用いた試験管内変換系の構築に基づくプリオン変換・生成機構の解明. Invited
今村守一,森剛志,高月英恵,岩丸祥史,新竜一郎
YAKUGAKU ZASSHI 139 ( 7 ) 989 - 992 2019.7
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:公益財団法人日本薬学会
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Real-time quaking-induced conversion for diagnosis of prion disease. Reviewed
Satoh K*, Atarashi R, Nishida N
Methods Mol Biol. 1658 305 - 310 2017.9
Language:English Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:Springer
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プリオン病の新規増幅検出法の開発と診断への応用. Invited
新竜一郎
宮崎県医師会医学会誌 41 ( 2 ) 65 - 70 2017.9
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:宮崎県医師会
Presentations 【 display / non-display 】
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Development of therapeutic agents for prion diseases based on structural analysis of abnormal prion protein International conference
Kazuki Kanemaru, Takeshi Ishikawa, Ryuichiro Atarashi
アジア太平洋プリオン研究会2025 2025.11.27
Event date: 2025.11.27 - 2025.11.28
Language:English Presentation type:Oral presentation (general)
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Serine protease-mediated spontaneous amyloid formation revealed by the RT-QuIC assay International conference
Tsuyoshi Mori, Morikazu Imamura, Hanae Takatsuki, Kazuki Kanemaru, Minako Ohno, Ryuichiro Atarashi
アジア太平洋プリオン研究会2025 2025.11.27
Event date: 2025.11.27 - 2025.11.28
Language:English Presentation type:Poster presentation
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Treatment with triprolidine in the late stages of prion infection prolongs survival of prion infected mice International conference
Hanae Takatsuki, Morikazu Imamura, Takehiro Nakagaki, Miho kaneko, Tsuyoshi Mori, Ryuichiro Atarashi
アジア太平洋プリオン研究会2024 2024.11.30
Event date: 2024.11.30 - 2024.12.1
Language:English Presentation type:Oral presentation (general)
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Oral Transmission of L-type Bovine Spongiform Encephalopathy in Cynomolgus Macaques: Detection of Classical BSE-like Prions in Lymphoid Tissues and Peripheral Nerves International conference
Morikazu Imamura, Kenichi Hagiwara, Minoru Tobiume, Minako Ohno, Hiromi Iguchi, Hanae Takatsuki, Tsuyoshi Mori, Ryuichiro Atarashi, Hiroaki Shibata, Fumiko Ono
アジア太平洋プリオン研究会2024 2024.11.30
Event date: 2024.11.30 - 2024.12.1
Language:English Presentation type:Oral presentation (general)
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Prion Disease Research Today Invited
Ryuichiro Atarashi
The 96th annual meeting of Japanese Society for Bacteriology 2023.3.16
Event date: 2023.3.16 - 2023.3.18
Language:Japanese Presentation type:Symposium, workshop panel (nominated)
Awards 【 display / non-display 】
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平成22年度長崎県科学技術大賞受賞
2011.3 長崎県
超高感度プリオン検出法の開発
Country:Japan
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第26回長崎大学角尾学術賞受賞
2009.5 長崎大学
感染病原体プリオン増殖機構の解明とプリオン病の早期診断法の開発
Country:Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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抗プリオン薬のプリオン株特異的有効性と薬剤耐性機構の解明
Grant number:23H02828 2023 - 2027.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
Authorship:Principal investigator
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抗プリオン薬のプリオン株特異的有効性と薬剤耐性機構の解明
Grant number:23K27519 2023 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship:Principal investigator
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GPIアンカー修飾はアルファシヌクレイノパチーの病原性・伝達性を促進するか?
Grant number:20K21579 2020.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 挑戦的研究(萌芽)
Authorship:Principal investigator
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非定型BSE等動物プリオン病のヒトへの感染リスクの推定と低減に資する研究
Grant number:XA12010101 2020.04 - 2023.03
厚生労働省 厚生労働科学技術研究費補助金 食品の安全確保推進研究事業
Authorship:Coinvestigator(s)
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ネパールにおけるロタウイルス種間伝播機序とウイルス循環における成人の役割の解明
Grant number:19KK0245 2019.10 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 国際共同研究加速基金(国際共同研究強化(B))
Authorship:Principal investigator
Available Technology 【 display / non-display 】
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試験管内アミロイド高感度増幅法を用いた神経変性疾患鑑別診断法の開発
タンパク質異常凝集性神経変性疾患(認知症)の予防・治療法の開発
ロタウイルスの分子疫学的研究Related fields where technical consultation is available:・試験管内アミロイド高感度増幅法(RT-QuIC法等)を用いたタンパク質の凝集過程の解析
・ウイルスの分子疫学的研究Message:共同研究の希望テーマ: タンパク質異常凝集過程を抑制する化合物の発見・開発