ATARASHI Ryuichiro

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Infectious Diseases, Microbiology

Title

Professor

External Link

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Degree 【 display / non-display

  • 博士(医学) ( 2002.1   長崎大学 )

Research Areas 【 display / non-display

  • Life Science / Anatomy and histopathology of nervous system

 

Papers 【 display / non-display

  • Administration of L-Type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential Reviewed International journal

    Morikazu Imamura, Ken'ichi Hagiwara, Minoru Tobiume, Minako Ohno, Hiromi Iguchi, Hanae Takatsuki, Tsuyoshi Mori, Ryuichiro Atarashi, Hiroaki Shibata, Fumiko Ono

    Emerg Infect Dis.   31 ( 5 )   986 - 990   2025.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:CDC  

    We administered L-type bovine spongiform encephalopathy prions to macaques to determine their potential for transmission to humans. After 75 months, no clinical symptoms appeared, and prions were undetectable in any tissue by Western blot or immunohistochemistry. Protein misfolding cyclic amplification, however, revealed prions in the nerve and lymphoid tissues.

    DOI: 10.3201/eid3105.241257.

  • Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures. Reviewed

    Takatsuki H, Imamura M, Mori T, Atarashi R

    Sci Rep   12 ( 1 )   7923   2022.5

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-12049-z

  • Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system. Reviewed

    Imamura M, Tabeta N, Iwamaru Y, Takatsuki H, Mori T, Atarashi R

    Biochem Biophys Res Commun   613   67 - 72   2022.5

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2022.04.137

  • Discrimination between L-type and C-type bovine spongiform encephalopathy by the strain-specific reactions of real-time quaking-induced conversion. Reviewed

    Ubagai K, Fukuda S, Mori T, Takatsuki H, Taguchi Y, Kageyama S, Nishida N, Atarashi R

    Biochem Biophys Res Commun   526 ( 4 )   1049 - 1053   2020.6

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2020.03.183

  • Identification of alprenolol hydrochloride as an anti-prion compound using surface plasmon resonance imaging. Reviewed

    Miyazaki Y, Ishikawa T, Kamatari YO, Nakagaki T, Takatsuki H, Ishibashi D, Kuwata K, Nishida N, Atarashi R

    Mol Neurobiol   56 ( 1 )   367 - 377   2019.1

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12035-018-1088-7

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Books 【 display / non-display

  • 標準微生物学 第14版

    新竜一郎( Role: Joint author ,  ピコルナウイルス科(第34章プラス鎖RNAウイルス))

    医学書院  2021.3 

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    Total pages:690   Responsible for pages:425-431   Language:Japanese Book type:Scholarly book

  • 標準微生物学 第13版

    新竜一郎( Role: Joint author ,  ピコルナウイルス科(第34章プラス鎖RNA型ウイルス))

    医学書院  2018.3 

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    Total pages:663   Responsible for pages:403-411   Language:Japanese Book type:Scholarly book

  • Annual Review神経

    新竜一郎, 佐藤克也( Role: Joint author ,  プリオン病の髄液診断の可能性)

    中外医学社  2011.1 

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    Language:Japanese Book type:Scholarly book

  • モデル動物の作成と維持

    新竜一郎, 片峰茂( Role: Joint author ,  第3節感染・免疫 第1項プリオン病)

    エル・アイ・シー  2004.7 

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    Language:Japanese Book type:Scholarly book

  • 実験医学

    中桶了太, 新竜一郎, 片峰茂( Role: Joint author ,  ジーンターゲッティングの実際・PrP遺伝子)

    羊土社  1996.12 

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    Language:Japanese Book type:Scholarly book

MISC 【 display / non-display

  • 異常型プリオンタンパク質の高感度増幅技術とその応用 Invited

    新竜一郎

    ファルマシア   62 ( 2 )   112 - 115   2026.2

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

    DOI: https://doi.org/10.14894/faruawpsj.62.2_112

  • RT‑QuIC as ultrasensitive method for prion detection. Invited Reviewed

    Atarashi Ryuichiro

    Cell Tissue Res   392 ( 1 )   295 - 300   2022.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1007/s00441-021-03568-8.

  • バキュロウイルス-昆虫細胞発現組換えPrP を用いた試験管内変換系の構築に基づくプリオン変換・生成機構の解明. Invited

    今村守一,森剛志,高月英恵,岩丸祥史,新竜一郎

    YAKUGAKU ZASSHI   139 ( 7 )   989 - 992   2019.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:公益財団法人日本薬学会  

  • Real-time quaking-induced conversion for diagnosis of prion disease. Reviewed

    Satoh K*, Atarashi R, Nishida N

    Methods Mol Biol.   1658   305 - 310   2017.9

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:Springer  

    DOI: 10.1007/978-1-4939-7244-9_21.

  • プリオン病の新規増幅検出法の開発と診断への応用. Invited

    新竜一郎

    宮崎県医師会医学会誌   41 ( 2 )   65 - 70   2017.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:宮崎県医師会  

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Presentations 【 display / non-display

  • Development of therapeutic agents for prion diseases based on structural analysis of abnormal prion protein International conference

    Kazuki Kanemaru, Takeshi Ishikawa, Ryuichiro Atarashi

    アジア太平洋プリオン研究会2025  2025.11.27 

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    Event date: 2025.11.27 - 2025.11.28

    Language:English   Presentation type:Oral presentation (general)  

  • Serine protease-mediated spontaneous amyloid formation revealed by the RT-QuIC assay International conference

    Tsuyoshi Mori, Morikazu Imamura, Hanae Takatsuki, Kazuki Kanemaru, Minako Ohno, Ryuichiro Atarashi

    アジア太平洋プリオン研究会2025  2025.11.27 

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    Event date: 2025.11.27 - 2025.11.28

    Language:English   Presentation type:Poster presentation  

  • Treatment with triprolidine in the late stages of prion infection prolongs survival of prion infected mice International conference

    Hanae Takatsuki, Morikazu Imamura, Takehiro Nakagaki, Miho kaneko, Tsuyoshi Mori, Ryuichiro Atarashi

    アジア太平洋プリオン研究会2024  2024.11.30 

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    Event date: 2024.11.30 - 2024.12.1

    Language:English   Presentation type:Oral presentation (general)  

  • Oral Transmission of L-type Bovine Spongiform Encephalopathy in Cynomolgus Macaques: Detection of Classical BSE-like Prions in Lymphoid Tissues and Peripheral Nerves International conference

    Morikazu Imamura, Kenichi Hagiwara, Minoru Tobiume, Minako Ohno, Hiromi Iguchi, Hanae Takatsuki, Tsuyoshi Mori, Ryuichiro Atarashi, Hiroaki Shibata, Fumiko Ono

    アジア太平洋プリオン研究会2024  2024.11.30 

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    Event date: 2024.11.30 - 2024.12.1

    Language:English   Presentation type:Oral presentation (general)  

  • Prion Disease Research Today Invited

    Ryuichiro Atarashi

    The 96th annual meeting of Japanese Society for Bacteriology  2023.3.16 

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    Event date: 2023.3.16 - 2023.3.18

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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Awards 【 display / non-display

  • 平成22年度長崎県科学技術大賞受賞

    2011.3   長崎県  

    超高感度プリオン検出法の開発

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    Country:Japan

  • 第26回長崎大学角尾学術賞受賞

    2009.5   長崎大学  

    感染病原体プリオン増殖機構の解明とプリオン病の早期診断法の開発

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    Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • 抗プリオン薬のプリオン株特異的有効性と薬剤耐性機構の解明

    Grant number:23H02828  2023 - 2027.03

    独立行政法人日本学術振興会  科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  • 抗プリオン薬のプリオン株特異的有効性と薬剤耐性機構の解明

    Grant number:23K27519  2023 - 2027.03

    独立行政法人日本学術振興会  科学研究費基金  基盤研究(B)

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    Authorship:Principal investigator 

  • GPIアンカー修飾はアルファシヌクレイノパチーの病原性・伝達性を促進するか?

    Grant number:20K21579  2020.04 - 2024.03

    独立行政法人日本学術振興会  科学研究費補助金  挑戦的研究(萌芽)

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    Authorship:Principal investigator 

  • 非定型BSE等動物プリオン病のヒトへの感染リスクの推定と低減に資する研究

    Grant number:XA12010101  2020.04 - 2023.03

    厚生労働省  厚生労働科学技術研究費補助金  食品の安全確保推進研究事業

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    Authorship:Coinvestigator(s) 

  • ネパールにおけるロタウイルス種間伝播機序とウイルス循環における成人の役割の解明

    Grant number:19KK0245  2019.10 - 2025.03

    独立行政法人日本学術振興会  科学研究費基金  国際共同研究加速基金(国際共同研究強化(B))

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    Authorship:Principal investigator 

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