Papers - ATARASHI Ryuichiro
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Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures. Reviewed
Takatsuki H, Imamura M, Mori T, Atarashi R
Sci Rep 12 ( 1 ) 7923 2022.5
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system. Reviewed
Imamura M, Tabeta N, Iwamaru Y, Takatsuki H, Mori T, Atarashi R*
Biochem Biophys Res Commun 613 67 - 72 2022.5
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Discrimination between L-type and C-type bovine spongiform encephalopathy by the strain-specific reactions of real-time quaking-induced conversion. Reviewed
Ubagai K, Fukuda S, Mori T, Takatsuki H, Taguchi Y, Kageyama S, Nishida N, Atarashi R
Biochem Biophys Res Commun 526 ( 4 ) 1049 - 1053 2020.6
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Identification of alprenolol hydrochloride as an anti-prion compound using surface plasmon resonance imaging. Reviewed
Miyazaki Y, Ishikawa T, Kamatari YO, Nakagaki T, Takatsuki H, Ishibashi D, Kuwata K, Nishida N, Atarashi R
Mol Neurobiol 56 ( 1 ) 367 - 377 2019.1
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic CJD: An international study. Reviewed International coauthorship
McGuire, L.I., Poleggi, A., Poggiolini, I., Suardi, S., Grznarova, K., Shi, S., de Vil, B., Sarros, S., Satoh, K., Cheng, K., Cramm, M., Fairfou,l G., Schmitz, M., Zerr, I., Cras, P., Equestre, M., Tagliavini, F., Atarashi, R., Knox, D., Collins, S., Haïk, S., Parchi, P., Pocchiari, M., Green, A.
Annals of neurology 80 ( 1 ) 160 - 165 2016.4
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1002/ana.24679.
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Conformational properties of prion strains can be transmitted to recombinant prionprotein fibrils in real-time quaking-induced conversion. Reviewed
Sano K, Atarashi R, Ishibashi D, Nakagaki T, Satoh K, Nishida N
Journal of Virology 88 ( 20 ) 11791 - 11801 2014.10
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. Reviewed
Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, Kitani H, Nishida N, Atarashi R
Autophagy 9 ( 9 ) 1386 - 1394 2013.6
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.4161/auto.25381
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Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Reviewed
Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N
Nature Medicine 17 ( 2 ) 175 - 178 2011.1
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1038/nm.2294
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Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. Reviewed International coauthorship
Wilham JM, Orrú CD, Bessen RA, Atarashi R, Sano K, Race B, Meade-White KD, Taubner LM, Timmes A, Caughey B
PLoS Pathogens 6 ( 12 ) e1001217 2010.12
Language：English Publishing type：Research paper (scientific journal)
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Hyperefficient PrP Sc amplification of mouse-adapted BSE and scrapie strain by protein misfolding cyclic amplification technique. Reviewed
Fujihara A, Atarashi R, Fuse T, Ubagai K, Nakagaki T, Yamaguchi N, Ishibashi D, Katamine S, Nishida N
The FEBS Journal 276 ( 10 ) 2841 - 2848 2009.4
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Reviewed International coauthorship
Atarashi R, Moore RA, Sim VL, Hughson AG, Dorward DW, Onwubiko HA, Priola SA, Caughey B
Nature methods 4 ( 8 ) 645 - 650 2007.7
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1038/nmeth1066
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Prion strain-dependent differences in conversion of mutant prion proteins in cell culture. Reviewed International coauthorship
Atarashi R, Sim VL, Nishida N, Caughey B, Katamine S
Journal of Virology 80 ( 16 ) 7854 - 7862 2006.8
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1128/JVI.00424-06
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Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration. Reviewed
Atarashi R, Nishida N, Shigematsu K, Goto S, Kondo T, Sakaguchi S, Katamine S
The Journal of biological chemistry 278 ( 31 ) 28944 - 28949 2003.8
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Lysine residues are not required for proteasome-mediated proteolysis of cellular prion protein Reviewed
Nishinakagawa T., Homma T., Ikeda A., Hazekawa M., Morita Y., Nakagaki T., Atarashi R., Nishida N., Ishibashi D.
Biochemical and Biophysical Research Communications 735 150807 2024.11
Language：English Publishing type：Research paper (scientific journal) Publisher：Biochemical and Biophysical Research Communications
Cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein. The mature cell-surface PrPC is internalized and subsequently degraded by lysosomes. Although, proteasomes are proposed to be involved, the precise mechanism of PrPC degradation remains uncertain. Given that proteins are ubiquitinated primarily on lysine residues, we sought to determine whether lysine residues within PrPC are involved in the ubiquitination and subsequent degradation of PrPC. We generated a plasmid vector expressing a mutant PrPC (called lysine-null PrPC) in which all lysine residues were replaced with arginine residues. Subsequently, we established stably transformed cell lines (designated HpL2-1 PrP-WT and HpL2-1 PrP-K/R, respectively) using the mouse PrPC-deficient neuronal cell line (HpL2-1) and plasmids expressing wild-type (WT) or lysine-null PrPC (PrP-K/R). We found that HpL2-1 PrP-WT and HpL2-1 PrP-K/R cells correctly expressed their respective PrPC which translocated efficiently to the plasma membrane. Subsequently, using immunoblotting and confocal microscopy, we found that treatment with cycloheximide (CHX; a protein synthesis inhibitor) significantly reduced PrPC expression in both these transformed cell lines, indicating that WT and lysine-null PrPC are degraded similarly. Taken together, these results indicate that the lysine residues of PrPC do not regulate its degradation.
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RT-QuIC as ultrasensitive method for prion detection
Atarashi R.
Cell and Tissue Research 392 ( 1 ) 295 - 300 2023.4
Language：English Publishing type：Research paper (scientific journal) Publisher：Cell and Tissue Research
Real-time quaking-induced conversion (RT-QuIC) is a cell-free abnormal form of prion protein (PrPSc) amplification method using recombinant prion protein from Escherichia coli that can measure prion seeding activity in samples with high sensitivity. The advantages of this method are that it is much more sensitive than Western blotting, which is usually used to detect PrPSc, and that prion seeding activity can be easily quantified by combining it with endpoint dilution of the sample, and that it can be amplified in most species and prion strains. A decade has passed since the development of RT-QuIC, and many studies have been reported that take advantage of its characteristics. In particular, its usefulness in the diagnosis of sporadic CJD has been clarified, and it is recommended to be one of the diagnostic criteria. Future challenges include the establishment of a method to differentiate prion strains and application of RT-QuIC to early diagnosis of prion diseases and determination of treatment efficacy.
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Central residues in prion protein PrPC are crucial for its conversion into the pathogenic isoform. Reviewed
Pasiana AD, Miyata H, Chida J, Hara H, Imamura M, Atarashi R, Sakaguchi S
The Journal of biological chemistry 298 ( 9 ) 102381 2022.9
Language：English Publishing type：Research paper (scientific journal)
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Ethanolamine is a new anti-prion compound. Reviewed
Uchiyama K, Hara H, Chida J, Pasiana AD, Imamura M, Mori T, Takatsuki H, Atarashi R, Sakaguchi S
Int J Mol Sci 22 ( 21 ) 11742 2021.10
Language：English Publishing type：Research paper (scientific journal)
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Dextran sulphate inhibits an association of prions with plasmamembrane at the early phase of infection. Reviewed
Fuse T, Nakagaki T, Homma T, Tange H, Yamaguchi N, Atarashi R, Ishibashi D*, Nishida N
Neuroscience Research 171 34 - 40 2021.1
Language：English Publishing type：Research paper (scientific journal)
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Strain-dependent prion infection in mice expressing prion protein with deletion of central residues 91-106. Reviewed
Uchiyama K, Miyata H, Yamaguchi Y, Imamura M, Okazaki M, Pasiana AD, Chida J, Hara H, Atarashi R, Watanabe H, Kondoh G, Sakaguchi S
Int J Mol Sci 21 ( 19 ) 7260 2020.10
Language：English Publishing type：Research paper (scientific journal)
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Impairment of cerebellar long-term depression and GABAergic transmission in prion protein deficient mice ectopically expressing PrPLP/Dpl. Reviewed
Kishimoto Y, Hirono M, Atarashi R, Sakaguchi S, Yoshioka T, Katamine S, Kirino Y
Sci Rep 10 ( 1 ) 15900 2020.9
Language：English Publishing type：Research paper (scientific journal)
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Feasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain. Reviewed
Fuchigami T, Kawasaki M, Watanabe H, Nakagaki T, Nishi K, Sano K, Atarashi R, Nakaie M, Yoshida S, Ono M, Nishida N, Nakayama M
Nucl Med Biol 90-91 41 - 48 2020.9
Language：English Publishing type：Research paper (scientific journal)
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Administration of FK506 from late stage of disease prolongs survival of human prion-inoculated mice. Reviewed
Nakagaki T*, Ishibashi D, Mori T, Miyazaki Y, Takatsuki H, Tange H, Taguchi Y, Satoh K, Atarashi R, Nishida N
Neurotherapeutics 2020.6
Language：English Publishing type：Research paper (scientific journal)
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Prion protein interacts with the metabotropic glutamate receptor 1 and regulates the organization of Ca2+ signaling. Reviewed
Matsubara T, Satoh K, Homma T, Nakagaki T, Yamaguchi N, Atarashi R, Sudo Y, Uezono Y, Ishibashi D*, Nishida N.
Biochem Biophys Res Commun 525 ( 2 ) 447 - 454 2020.4
Language：English Publishing type：Research paper (scientific journal)
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Estimation of prion infectivity in tissues of cattle infected with atypical BSE by real time-quaking induced conversion assay. Reviewed
Sawada K, Suzuki A, Yamasaki T, Iwamaru Y, Matsuura Y, Miyazawa K, Masujin K, Atarashi R, Horiuchi M.
J Vet Med Sci 81 ( 6 ) 846 - 850 2019.6
Language：English Publishing type：Research paper (scientific journal)
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Type I interferon protects neurons from prions in in vivo models. Reviewed
Ishibashi D*, Homma T, Nakagaki T, FuseT, Sano K, Satoh K, Mori T, Atarashi R and Nishida N.
Brain 142 ( 4 ) 1035 - 1050 2019.4
Language：English Publishing type：Research paper (scientific journal)
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Development of Radioiodinated Benzofuran Derivatives for in Vivo Imaging of Prion Deposits in the Brain. Reviewed
Fuchigami T, Kawasaki M, Koyama R, Nakaie M, Nakagaki T, Sano K, Atarashi R, Yoshida S, Haratake M, Ono M, Nishida N, Nakayama M
ACS Infect Dis 5 ( 12 ) 2003 - 2013 2019.3
Language：English Publishing type：Research paper (scientific journal)
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Whole genome characterisation of G11P[25] and G9P[19] rotavirus A strains from adult patients with diarrhoea in Nepal. Reviewed International coauthorship
Takatsuki H*, Agbemabiese CA, Nakagomi T, Pun SB, Gauchan P, Muto H, Masumoto H, Atarashi R, Nakagomi O, Pandey BD.
Infect Genet Evol 69 246 - 254 2019.2
Language：English Publishing type：Research paper (scientific journal)
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Proteomic approach to profiling immune complex antigens in cerebrospinal fluid samples from patients with central nervous system autoimmune diseases. Reviewed
Aibara N, Ichinose K, Baba M, Nakajima H, Satoh K, Atarashi R, Kishikawa N, Nishida N, Kawakami A, Kuroda N, Ohyama K.
Clin Chim Acta 484 26 - 31 2018.5
Language：English Publishing type：Research paper (scientific journal)
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Prion-like seeding of misfolded α-synuclein in the brains of dementia with Lewy body patients in RT-QUIC. Reviewed
Sano, K., Atarashi, R., Satoh, K., Ishibashi, D., Nakagaki, T., Iwasaki. Y., Yoshida, M., Murayama, S., Mishima, K., Nishida, N.
Molecular Neurobiology 55 ( 5 ) 3916 - 3930 2018.5
Language：English Publishing type：Research paper (scientific journal)
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Development of radioiodinated acridine derivatives for in vivo imaging of prion deposits in the brain. Reviewed
Kawasaki, M., Fuchigami, T., Kobashi, N., Nakagaki, T., Sano, K., Atarashi, R., Yoshida, S., Haratake, M., Nishida, N., Nakayama, M.
Bioorganic & Medicinal Chemistry 25 ( 3 ) 1085 - 1093 2017.2
Language：English Publishing type：Research paper (scientific journal)
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The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases. Reviewed International coauthorship
Schmitz, M., Cramm, M., Llorens, F., Müller-Cramm, D., Collins, S., Atarashi, R., Satoh, K., Orrù, C.D., Groveman, B.R., Zafar, S., Schulz-Schaeffer, W.J., Caughey, B., Zerr, I.
Nature Protocols 11 ( 11 ) 2233 - 2242 2016.11
Language：English Publishing type：Research paper (scientific journal)
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Prion-seeding activity is widely distributed in tissues of sporadic Creutzfeldt-Jakob disease patients. Reviewed
Takatsuki, H., Fuse, T., Nakagaki, T., Mori, T., Mihara, B., Takao, M., Iwasaki, Y., Yoshida, M., Murayama, S., Atarashi, R., Nishida, N., Satoh, K.
EBioMedicine. 12 150 - 155 2016.10
Language：English Publishing type：Research paper (scientific journal)
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Structure-based drug discovery for prion disease using a novel binding simulation. Reviewed
Ishibashi, D., Nakagaki, T., Ishikawa, T., Atarashi, R., Watanabe, K., Cruz, F.A., Hamada, T., Nishida, N.
EBioMedicine 9 238 - 249 2016.7
Language：English Publishing type：Research paper (scientific journal)
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A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion. Reviewed
Mori, T., Atarashi, R., Furukawa, K., Takatsuki, H., Satoh, K., Sano, K., Nakagaki, T., Ishibashi, D., Ichimiya, K., Hamada, M., Nakayama, T., Nishida, N.
Scientific reports 6 24993 2016.4
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1038/srep24993.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Reviewed International coauthorship
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, et al.
Autophagy 12 ( 1 ) 1 - 222 2016.1
Language：English Publishing type：Research paper (scientific journal)
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Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits. Reviewed
Fuchigami T, Yamashita Y, Kawasaki M, Ogawa A, Haratake M, Atarashi R, Sano K, Nakagaki T, Ubagai K, Ono M, Yoshida S, Nishida N, Nakayama M.
Scientific reports 5 18440 2015.12
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1038/srep18440
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Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells. Reviewed
Ishibashi D, Homma T, Nakagaki T, Fuse T, Sano K, Takatsuki H, Atarashi R, Nishida N.
PLoS One 10 ( 9 ) e0137958 2015.9
Language：English Publishing type：Research paper (scientific journal)
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Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases. Reviewed
Takatsuki H, Satoh K*, Sano K, Fuse T, Nakagaki T, Mori T, Ishibashi D, Mihara B, Takao M, Iwasaki Y, Yoshida M, Atarashi R, Nishida N
PLoS One 10 ( 6 ) e0126930 2015.6
Language：English Publishing type：Research paper (scientific journal)
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Ubiquitin-specific protease 14 modulates degradation of cellular prion protein. Reviewed
Homma T, Ishibashi D, Nakagaki T, Fuse T, Mori T, Satoh K, Atarashi R, Nishida N
Scientific Reports 5 11028 2015.6
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1038/srep11028.
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Pressure-assisted dissociation and degradation of "proteinas K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein. Reviewed
Akasaka K, Maeno A, Murayama T, Tachibana H, Fujita Y, Yamanaka H, Nishida N, Atarashi R.
Prion 8 ( 4 ) 314 - 318 2014.11
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.4161/pri.32081.
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Persistent prion infection disturbs the function of Oct-1, resultingin the down-regulation of murine interferon regulatory factor-3. Reviewed
Homma T, Ishibashi D, Nakagaki T, Fuse T, Sano K, Satoh K, Atarashi R,Nishida N.
Scientific Reports 4 6006 2014.8
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1038/srep06006.
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Clinical features of genetic Creutzfeldt-Jakob disease with V180I mutation in the prion protein gene. Reviewed
Qina T, Sanjo N*, Hizume M, Higuma M, Tomita M, Atarashi R, Satoh K, Nozaki I, Hamaguchi T, Nakamura Y, Kobayashi A, Kitamoto T, Murayama S, Murai H, Yamada M, Mizusawa H
BMJ Open 4 ( 5 ) e004968 2014.5
Language：English Publishing type：Research paper (scientific journal)
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Increased expression of p62/SQSTM1 in prion diseases and its associationwith pathogenic prion protein. Reviewed
Homma T, Ishibashi D*, Nakagaki T, Satoh K, Sano K, Atarashi R, Nishida N
Scientific reports 4 4504 2014.3
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1038/srep04504.
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Age-dependent impairment of eyeblink conditioning in prion protein-deficient mice. Reviewed
Kishimoto Y, Hirono M, Atarashi R, Sakaguchi S, Yoshioka T, Katamine S, Kirino Y
PLoS One 8 ( 4 ) e60627 2013.4
Language：English Publishing type：Research paper (scientific journal)
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Early Detection of Abnormal Prion Protein in Genetic Human Prion Diseases Now Possible Using Real-Time QUIC Assay. Reviewed International coauthorship
Sano K, Satoh K, Atarashi R, Takashima H, Iwasaki Y, Yoshida M, Sanjo N, Murai H, Mizusawa H, Schmitz M, Zerr I, Kim YS, Nishida N
PLoS One 8 ( 1 ) e54915 2013.1
Language：English Publishing type：Research paper (scientific journal)
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Cutting Edge: Brucella abortus exploits a cellular prion protein on intestinal M cells as an invasive receptor. Reviewed
Nakato G, Hase K, Suzuki M, Kimura M, Ato M, Hanazato M, Tobiume M, Horiuchi M, Atarashi R, Nishida N, Watarai M, Imaoka K, Ohno H
Journal of immunology (Baltimore, Md. : 1950) 189 ( 4 ) 1540 - 1544 2012.8
Language：English Publishing type：Research paper (scientific journal)
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Protective role of interferon regulatory factor 3-mediated signaling against prion infection. Reviewed
Ishibashi D, Atarashi R, Fuse T, Nakagaki T, Yamaguchi N, Satoh K, Honda K, Nishida N
Journal of Virology 86 ( 9 ) 4947 - 4955 2012.2
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1128/JVI.06326-11
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Multicentre multiobserver study of diffusion-weighted and fluid-attenuated inversion recovery MRI for the diagnosis of sporadic Creutzfeldt-Jakob disease: a reliability and agreement study. Reviewed
Fujita K*, Harada M, Sasaki M, Yuasa T, Sakai K, Hamaguchi T, Sanjo N,Shiga Y, Satoh K, Atarashi R, Shirabe S, Nagata K, Maeda T, Murayama S,Izumi Y, Kaji R, Yamada M, Mizusawa H
BMJ Open 2 ( 1 ) e000649 2012.1
Language：English Publishing type：Research paper (scientific journal)
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High sensitivity of an ELISA kit for detection of the gamma-isoform of 14-3-3 proteins: usefulness in laboratory diagnosis ofhuman prion disease. Reviewed
Matsui Y, Satoh K*, Miyazaki T, Shirabe S, Atarashi R, Mutsukura K, Satoh A, Kataoka Y, Nishida N
BMC Neurology 11 120 2011.10
Language：English Publishing type：Research paper (scientific journal)
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Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors. Reviewed International coauthorship
Kim JI, Cali I, Surewicz K, Kong Q, Raymond GJ, Atarashi R, Race B, Qing L, Gambetti P, Caughey B, Surewicz WK
The Journal of Biological Chemistry 285 ( 19 ) 14083 - 14087 2010.5
Language：English Publishing type：Research paper (scientific journal)
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Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. Reviewed International coauthorship
Smirnovas V, Kim JI, Lu X, Atarashi R, Caughey B, Surewicz WK
The Journal of Biological Chemistry 284 ( 36 ) 24233 - 24234 2009.9
Language：English Publishing type：Research paper (scientific journal)
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Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Reviewed International coauthorship
Atarashi R, Wilham JM, Christensen L, Hughson AG, Moore RA, Johnson LM, Onwubiko HA, Priola SA, Caughey B
Nature methods 5 ( 3 ) 211 - 212 2008.3
Language：English Publishing type：Research paper (scientific journal)
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Biological and biochemical characteristics of prion strains conserved in persistently infected cell cultures. Reviewed
Arima K, Nishida N, Sakaguchi S, Shigematsu K, Atarashi R, Yamaguchi N, Yoshikawa D, Yoon J, Watanabe K, Kobayashi N, Mouillet-Richard S, Lehmann S, Katamine S
Journal of virology 79 ( 11 ) 7104 - 7112 2005.6
Language：English Publishing type：Research paper (scientific journal)
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Abnormal activation of glial cells in the brains of prion protein-deficient mice ectopically expressing prion protein-like protein, PrPLP/Dpl. Reviewed
Atarashi R, Sakaguchi S, Shigematsu K, Arima K, Okimura N, Yamaguchi N, Li A, Kopacek J, Katamine S
Molecular Medicine 7 ( 12 ) 803 - 809 2001.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Early appearance but lagged accumulation of detergent-insoluble prion protein in the brains of mice inoculated with a mouse-adapted Creutzfeldt-Jakob disease agent. Reviewed
Nakaoke R, Sakaguchi S, Atarashi R, Nishida N, Arima K, Shigematsu K, Katamine S
Cellular and Molecular Neurobiology 20 ( 6 ) 717 - 730 2000.12
Language：English Publishing type：Research paper (scientific journal)
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Physiological expression of the gene for PrP-like protein, PrPLP/Dpl, by brain endothelial cells and its ectopic expression in neurons PrP-deficient mice ataxic due to Purkinje cell degeneration. Reviewed
Li A, Sakaguchi S, Shigematsu K, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Katamine S
The American Journal of Pathology 157 ( 5 ) 1447 - 1452 2000.11
Language：English Publishing type：Research paper (scientific journal)
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Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene. Reviewed
Li A, Sakaguchi S, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Shigematsu K
Cellular and Molecular Neurobiology 20 ( 5 ) 553 - 567 2000.10
Language：English Publishing type：Research paper (scientific journal)
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Upregulation of the genes encoding lysosomal hydrolases, a perforin-like protein, and peroxidases in the brains of mice affected with an experimental prion disease. Reviewed International coauthorship
Kopacek J, Sakaguchi S, Shigematsu K, Nishida N, Atarashi R, Nakaoke R, Moriuchi R, Niwa M, Katamine S
Journal of Virology 74 ( 1 ) 411 - 417 2000.1
Language：English Publishing type：Research paper (scientific journal)
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A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination. Reviewed International coauthorship
Nishida N, Tremblay P, Sugimoto T, Shigematsu K, Shirabe S, Petromilli C, Erpel SP., Nakaoke R, Atarashi R, Houtani T, Torchia M, Sakaguchi S, DeArmond SJ, Prusiner SB, Katamine S
Laboratory Investigation 79 ( 6 ) 689 - 697 1999.6
Language：English Publishing type：Research paper (scientific journal)
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Prion protein is necessary for latent learning and long-term memory retention. Reviewed
Nishida N, Katamine S*, Shigematsu K, Nakatani A, Sakamoto N, Hasegawa S, Nakaoke R, Atarashi R, Kataoka Y, Miyamoto T
Cellular and Molecular Neurobiology 17 ( 5 ) 537 - 545 1997.10
Language：English Publishing type：Research paper (scientific journal)