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Faculty of Medicine School of Medicine Department of Medicine of Pathophysiological Diagnosis and Therapy, Radiology |
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AZUMA Minako
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Papers 【 display / non-display 】
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Metastatic Cardiac Tumor Mimicking Coronary Artery Aneurysm on Postmortem Computed Tomography. Reviewed
Shinkawa N, Yamada R, Azuma M, Shinkawa N, Yukawa N
The American journal of forensic medicine and pathology 2025.3
Language：English Publishing type：Research paper (scientific journal)
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Oguri N., Gi T., Nakamura E., Maekawa K., Furukoji E., Okawa H., Kouyama S., Horiuchi S., Sawaguchi A., Sakae T., Azuma M., Asada Y., Yamashita A.
Research and Practice in Thrombosis and Haemostasis 9 ( 2 ) 2025.2
Language：English Publishing type：Research paper (scientific journal) Publisher：Research and Practice in Thrombosis and Haemostasis
Background: Novel anticoagulants targeting coagulation factor (F)XI/activated FXI (FXIa) are currently under development. However, whether FXI is present in human deep vein thrombosis (DVT) and whether FXIa and activated FX (FXa) play different roles in venous thrombus formation and hemostasis remain unclear. Objectives: To determine the presence of FXI in DVT and the effects of direct oral FXIa and FXa inhibitors on venous thrombus formation and hemostasis in rabbits and on in vitro thrombus formation. Methods: We immunohistochemically assessed FXI localization in human-aspirated DVT (n = 15). Additionally, we compared thrombus formation induced by endothelial denudation and stenosis or stasis in the jugular vein and skin bleeding time and volume between rabbits treated with direct FXIa inhibitors (ONO-1600586) and FXa inhibitors (rivaroxaban). Ex vivo rabbit and human blood were perfused in a flow chamber under low-shear rates (70/s). Results: FXI was localized in all DVT, predominantly in fibrin-rich areas. The FXI immunopositive area in the nonorganizing area was greater than that in the organizing area. Although FXIa and FXa inhibitors comparably inhibited venous thrombus formation, FXIa inhibitors did not affect bleeding time or volume in rabbits. FXIa or FXa inhibitors mildly or strongly inhibited fibrin formation at low-shear rates, respectively. Furthermore, the FXIa inhibitor suppressed human FXIa activity, thrombin generation, and fibrin formation during perfusion. Conclusion: The pathologic findings of human DVT suggest FXI's role in human DVT. FXIa inhibitors may inhibit less fibrin formation than FXa inhibitors and may explain the minor role of FXIa in hemostasis.
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Expression of fibroblast activation protein-α in human deep vein thrombosis Reviewed
Oguri N., Gi T., Nakamura E., Furukoji E., Goto H., Maekawa K., Tsuji A.B., Nishii R., Aman M., Moriguchi-Goto S., Sakae T., Azuma M., Yamashita A.
Thrombosis Research 241 109075 2024.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Thrombosis Research
Background: Fibroblast activation protein-α (FAP), a type-II transmembrane serine protease, is associated with wound healing, cancer-associated fibroblasts, and chronic fibrosing diseases. However, its expression in deep vein thrombosis (DVT) remains unclear. Therefore, this study investigated FAP expression and localization in DVT. Methods: We performed pathological analyses of the aspirated thrombi of patients with DVT (n = 14), classifying thrombotic areas in terms of fresh, cellular lysis, and organizing reaction components. The organizing reaction included endothelialization and fibroblastic reaction. We immunohistochemically examined FAP-expressed areas and cells, and finally analyzed FAP expression in cultured dermal fibroblasts. Results: All the aspirated thrombi showed a heterogeneous mixture of at least two of the three thrombotic areas. Specifically, 83 % of aspirated thrombi showed fresh and organizing reaction components. Immunohistochemical expression of FAP was restricted to the organizing area. Double immunofluorescence staining showed that FAP in the thrombi was mainly expressed in vimentin-positive or α-smooth muscle actin-positive fibroblasts. Some CD163-positive macrophages expressed FAP. FAP mRNA and protein levels were higher in fibroblasts with low-proliferative activity cultured under 0.1 % fetal bovine serum (FBS) than that under 10 % FBS. Fibroblasts cultured in 10 % FBS showed a significant decrease in FAP mRNA levels following supplementation with hemin, but not with thrombin. Conclusions: The heterogeneous composition of venous thrombi suggests a multistep thrombus formation process in human DVT. Further, fibroblasts or myofibroblasts may express FAP during the organizing process. FAP expression may be higher in fibroblasts with low proliferative activity.
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Sugita C., Maekawa K., Gi T., Oguri N., Nakamura E., Furukoji E., Azuma M., Asada Y., Yamashita A.
Thrombosis Research 238 185 - 196 2024.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Thrombosis Research
Background: Plaque erosion, a type of coronary atherothrombosis, involves superficial injury to smooth muscle cell (SMC)-rich plaques. Elevated levels of coagulation factor VIII (FVIII) correlate with an increased ischemic heart disease risk. FVIII may contribute to thrombus formation on eroded plaques. Aims: We aimed to elucidate the role of elevated FVIII in arterial thrombus formation within SMC-rich neointima in rabbits. Methods and results: We assessed the effect of recombinant human FVIII (rFVIII) on blood coagulation in vitro and platelet aggregation ex vivo. An SMC-rich neointima was induced through balloon injury to the unilateral femoral artery. Three weeks after the first balloon injury, superficial erosive injury and thrombus formation were initiated with a second balloon injury of the bilateral femoral arteries 45 min after the administration of rFVIII (100 IU/kg) or saline. The thrombus area and contents were histologically measured 15 min after the second balloon injury. rFVIII administration reduced the activated partial thromboplastin time and augmented botrocetin-induced, but not collagen- or adenosine 5′-diphosphate-induced, platelet aggregation. While rFVIII did not influence platelet-thrombus formation in normal intima, it increased thrombus formation on SMC-rich neointima post-superficial erosive injury. Enhanced immunopositivity for glycoprotein IIb/IIIa and fibrin was observed in rFVIII-administered SMC-rich neointima. Neutrophil count in the arterial thrombus on the SMC-rich neointima correlated positively with thrombus size in the control group, unlike the rFVIII group. Conclusions: Increased FVIII contributes to thrombus propagation within erosive SMC-rich neointima, highlighting FVIII's potential role in plaque erosion-related atherothrombosis.
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Uchimura R., Khant Z.A., Hayashi H., Nagayama Y., Uetani H., Kaku Y., Nagatomo T., Tamura Y., Yokogami K., Mukasa A., Kiyosue H., Azuma M., Hirai T.
Journal of Computer Assisted Tomography 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Computer Assisted Tomography
Objective Discriminating between hemorrhage and iodine extravasation can pose challenges in conventional computed tomography (CCT) images following preoperative embolization for meningioma. This study aimed to assess the efficacy of dual-energy computed tomography (DECT) in differentiating hemorrhage from iodine extravasation after preoperative embolization for meningioma. Methods Twenty-one consecutive meningioma patients who underwent CCT before and DECT immediately after preoperative embolization were included in this study. Two independent observers conducted qualitative assessments on CCT and virtual noncontrast (VNC) images and iodine maps (IMs) to differentiate between hemorrhage and iodine extravasation. One observer recorded CT values of hemorrhage and iodine extravasation on CCT and VNC images. The ratio of maximum attenuation to minimum attenuation on VNC images was defined as the VNC ratio. Statistical analysis included Kappa (κ) statistics, unpaired t tests, and receiver operating characteristic (ROC) analysis. Results Interobserver agreement for qualitative assessment was fair (κ = 0.231) for CCT alone and good (κ = 0.723) for CCT plus VNC imaging and IM. The addition of VNC imaging and IM to CCT improved differential confidence in 16 (76%) and 18 (86%) cases of the two observers, respectively, increasing the area under the receiver operating characteristic curve (AUROC) from 0.868 to 0.895 and 0.658 to 0.947, respectively. At a cutoff value of 1.527, the VNC ratio was significantly higher for hemorrhage than iodine extravasation (P < 0.05), with the highest diagnostic performance (AUROC, 1). Conclusions DECT with VNC imaging and IM is useful for differentiating hemorrhage from iodine extravasation in meningiomas with preoperative embolization.
Books 【 display / non-display 】
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宮崎県小児科医会会報
東 美菜子（ Role： Joint author , 【特別講演Ⅰ】画像診断における最近の話題）
宮崎県小児科医会 2023.3
Language：Japanese
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特集 ビギナーのための頭部画像診断 -Q＆Aアプローチ- 2023 所見別 小脳橋角部腫瘤はどのように考えればよいですか?
東 美菜子（ Role： Joint author）
学研メディカル秀潤社 2022.12
Language：Japanese Book type：Scholarly book
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臨床画像 2022年9月号
東 美菜子（ Role： Joint author , 特集 1 絶対苦手分野にしない 頭蓋底周辺の画像診断）
株式会社メジカルビュー社 2022.9
Language：Japanese Book type：Scholarly book
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日州医事 No.877
東 美菜子（ Role： Joint author , 画像診断とAI）
宮崎県医師会 2022.9
Language：Japanese Book type：Scholarly book
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月刊インナービジョン2022年9月号
東 美菜子（ Role： Joint author , Step up MRI 2022 MRI研究の最新動向&領域別MRI技術の臨床応用とトピックス）
インナービジョン 2022.9
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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整形トピックス CTにおける肋骨骨折自動検出
東 美菜子
整形外科 74 ( 10 ) 1080 - 1080 2023.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：南江堂
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特集 唾液腺･甲状腺をきわめる 顎下腺･舌下腺のCT･MRI -コンパクトな大唾液腺を診断する-
東 美菜子, 今田 真希
画像診断 43 ( 6 ) 526 - 535 2023.4
Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：学研メディカル秀潤社
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特集1 絶対苦手分野にしない 頭蓋底周辺の画像診断 良性腫瘍
東 美菜子
臨床画像 38 ( 9 ) 988 - 1001 2022.9
Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：メジカルビュー社
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特集1 絶対苦手分野にしない 頭蓋底周辺の画像診断 序説
東 美菜子
臨床画像 38 ( 9 ) 977 - 977 2022.9
Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：メジカルビュー社
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Azuma M., Nakada H., Takei M., Nakamura K., Katsuragawa S., Shinkawa N., Terada T., Masuda R., Hattori Y., Ide T., Kimura A., Shimomura M., Kawano M., Matsumura K., Meiri T., Ochiai H., Hirai T.
Emergency Radiology 29 ( 2 ) 425 2022.4
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Emergency Radiology
Presentations 【 display / non-display 】
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腹腔動脈瘤切除術後のバイパス吻合部に形成された仮性動脈瘤に対しcovered-stentを用いて治療を行った1例
原 卓也、古小路 英二、増田 梨絵、榮 建文、東 美菜子
第44回九州IVR研究会
Event date： 2022.12.17
Language：Japanese Presentation type：Oral presentation (general)
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神経眼科疾患の画像診断
東 美菜子
第24回北海道NR懇話会
Event date： 2022.12.10
Language：Japanese Presentation type：Oral presentation (invited, special)
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脳神経の画像診断
東 美菜子
第342回関西NR勉強会学術講演会
Event date： 2022.11.19
Language：Japanese Presentation type：Oral presentation (invited, special)
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頭蓋底周辺の画像診断
東 美菜子
第50回三重総合画像研究会
Event date： 2022.11.18
Language：Japanese Presentation type：Oral presentation (invited, special)
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QSMの臨床的有用性の検討
東 美菜子
令和4年度熊本大学放射線科MRI研究会
Event date： 2022.11.7
Language：Japanese Presentation type：Oral presentation (invited, special)
Awards 【 display / non-display 】
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Certificate of Merit
2021.12 Radiological Society of North America Contrast-enhanced 3D T2-FLAIR Imaging Of The Brain: What Should Radiologists Know?
Minako Azuma, Yoshihito Kadota, Toshinori Hirai
Award type：Award from international society, conference, symposium, etc.
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加藤賞
2021.2 日本神経放射線学会 Characterization of Carotid Plaque Components by Quantitative Susceptibility Mapping
M.Azuma, K.Maekawa, A.Yamashita, K.Yokogami, M.Enzaki, Z.A.Khant, H.Takeshima, Y.Asada, Y.Wang, T.Hirai
Award type：Award from Japanese society, conference, symposium, etc.
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Certificate of Merit
2020.7 European Congress of Radiology Detectability of renal cell carcinoma on CT in Japanese patients by using an AI algorithm with US patient data
M.Azuma, N.Terada, S.Mukai, D.-A.Bunu, T.Okada, T.Kamoto, K.Araki, T.Hirai
Award type：Award from international society, conference, symposium, etc.
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最優秀会長賞
2020.6 日本医学放射線学会 Prevalence of sellar spine in patients with central precocious puberty
Minako Azuma
Award type：Award from Japanese society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Synthetic MRIによる脳腫瘍の定量的評価：真の性状や拡がりを捉える手法の確立
Grant number：24K10787 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator
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神経変性疾患に対する定量的磁化率マッピングの有用性の検討
Grant number：16K19835 2016.04 - 2019.03
科学研究費補助金 若手研究(B)
Authorship：Principal investigator