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Affiliation |
Faculty of Agriculture Veterinary Teaching Hospital |
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Associate Professor |
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External Link |
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KANEKO Yasuyuki
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Papers 【 display / non-display 】
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Laparoscopic treatment of congenital portosystemic shunts with portal pressure measurement and portal angiography in 36 dogs Reviewed
2024.2
Authorship：Lead author Publishing type：Research paper (scientific journal)
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A chronic intermittent haemodialysis pig model for functional evaluation of dialysis membranes
Yamamoto S., Umeno H., Sano Y., Koremoto M., Goda Y., Kaneko Y., Torisu S., Tsuruda T., Fujimoto S.
International Journal of Artificial Organs 47 ( 5 ) 321 - 328 2024.5
Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Artificial Organs
Performance evaluation of new dialysis membranes is primarily performed in vitro, which can lead to differences in clinical results. Currently, data on dialysis membrane performance and safety are available only for haemodialysis patients. Herein, we aimed to establish an in vivo animal model of dialysis that could be extrapolated to humans. We created a bilateral nephrectomy pig model of renal failure, which placed a double-lumen catheter with the hub exposed dorsally. Haemodialysis was performed in the same manner as in humans, during which clinically relevant physiologic data were evaluated. Next, to evaluate the utility of this model, the biocompatibility of two kinds of membranes coated with or without vitamin E used in haemodiafiltration therapy were compared. Haemodialysis treatment was successfully performed in nephrectomized pigs under the same dialysis conditions (4 h per session, every other day, for 2 weeks). In accordance with human clinical data, regular dialysis alleviated renal failure in pigs. The vitamin E-coated membrane showed a significant reduction rate of advanced oxidation protein products during dialysis than non-coated membrane. In conclusion, this model mimics the pathophysiology and dialysis condition of patients undergoing haemodialysis. This dialysis treatment model of renal failure will be useful for evaluating the performance and safety of dialysis membranes.
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Shigemoto J., Kaneko Y., Kawazu M., Naganobu K., Torisu S.
Frontiers in Veterinary Science 11 2024
Publishing type：Research paper (scientific journal) Publisher：Frontiers in Veterinary Science
Introduction: Laparoscopic surgery is used for canine congenital extrahepatic portosystemic shunts (CEHPSS). However, outcomes of laparoscopic surgery involving simultaneous portal vein angiography and portal pressure measurement to attenuate or completely occlude the shunt vessel in canines remain unclear. This study aimed to evaluate outcomes and complications of laparoscopic portosystemic shunt occlusion (LAPSSO) for CEHPSS. Methods: Between June 2014 and March 2021, data on dogs undergoing cellophane banding (CB) and complete occlusion of laparoscopically treated congenital extrahepatic port shunts were collected from hospital records. Cases in which complete occlusion was laparoscopically performed, or a CB was used for gradual occlusion were included. A total of 36 dogs (14 males; median age 32.5 months [range, 5–99] with median body weight, 4.2 kg [range, 1.5–7.9]) that underwent LAPSSO for CEHPSS were included. All the dogs underwent computed tomographic angiography (CTA), and data on blood and radiological examinations were collected. Shunt vessel morphology was categorized using CTA findings. Portal pressure measurements and portal angiography were performed by accessing mesenteric and splenic veins in 30 and 6 cases, respectively. Results: The most common shunt types were spleno-phrenic shunts 16/36 (44.4%), followed by spleno-azygos 9/36 (25.0%), spleno-caval 4/36 (11.1%), right gastric-caval 6/36 (16.6%), and right gastric-caval with caudal loop shunts 1/36 (2.7%). The median portal pressure after complete occlusion was 11.5 mmHg (range, 4–16); portal pressures in the two dogs undergoing CB attenuation were 22 and 24 mmHg. The median operating time in the dogs with right (n = 25) and left (n = 11) recumbent positioning was 55 min (range, 28–120) and 54 min (range, 28–88), respectively. One dog had pneumothorax due to injury to the diaphragm. Another dog developed postoperative hypernatremia and succumbed 5 h post-procedure. Nevertheless, no other dogs exhibited signs of portal hypertension within 72 h. Blood tests and abdominal ultrasounds performed 1–2 months postoperatively revealed no residual shunts. Discussion: LAPSSO, coupled with portal pressure measurement and portal angiography, was shown as safe and effective approach that facilitated successful occlusion of CEHPSS. Further large-scale prospective studies and analyses of perioperative complications are needed.
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Expression patterns of aquaporins 1, 3, 5 in canine mammary gland carcinomas
FUJIMOTO Naruki, TANIGUCHI Yoshiki, SONODA Hiroko, KANEKO Yasuyuki, MATSUZAKI Toshiyuki, ITOH Teruo, HIRAI Takuya, UCHIDA Kazuyuki, IKEDA Masahiro
Journal of Veterinary Medical Science advpub ( 0 ) 2023.12
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
DOI： 10.1292/jvms.23-0278
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Shofa M., Ohkawa A., Kaneko Y., Saito A.
Antiviral Research 217 105695 2023.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Antiviral Research
The Orthohepadnavirus genus includes hepatitis B virus (HBV) that can cause chronic hepatitis and hepatocarcinoma in humans. Recently, a novel hepadnavirus in cats, domestic cat hepadnavirus (DCH), was identified that is genetically close to HBV. DCH infection is associated with chronic hepatitis in cats, suggesting a similarity with HBV pathogenesis and the potential to use DCH as a novel animal model for HBV research. HBV is shown to use the sodium/bile acid cotransporter (NTCP) as a major cell entry receptor, but the equivalent receptor for DCH remains unknown. Here we sought to identify the entry receptor for DCH. HBV- and DCH-derived preS1 peptides efficiently bound to both human and cat NTCPs, and residue 158 of NTCP proteins determined the species-specific binding of the DCH preS1 peptide. Myrcludex B, an HBV entry inhibitor, blocked the binding of the DCH preS1 peptide. Thus, DCH and HBV may share cell entry molecules, suggesting a possibility of inter-species transmission. Furthermore, our study suggests that DCH can be useful as a novel model for HBV research.
MISC 【 display / non-display 】
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Chair Summary of the Symposium “Perioperative Managements Learning from High-Risk Cases” at the 105th Meeting of the Japanese Society of Veterinary Anesthesia and Surgery
ITOH Teruo, KANEKO Yasuyuki, KIM Sangho
Japanese Journal of Veterinary Anesthesia & Surgery 54 ( 1 ) 27 - 33 2023
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Japanese Society of Veterinary Anesthesia and Surgery
DOI： 10.2327/jjvas.54.27
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臨床獣医師のための内科文献情報 Invited
金子 泰之
SA Medicine 26 ( 152 ) 71 - 71 2020.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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胆道系手術の合併症 Invited
金子 泰之
SURGEON 24 ( 24 ) 38 - 57 2020.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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胆嚢粘液嚢腫（胆嚢穿孔、破裂を起こしていた症例） Invited
金子 泰之
VETERINARY BOARD 1 ( 1 ) 38 - 46 2019.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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Oncologic Emergency ~胆道閉塞~ Invited
金子 泰之、鳥巣至道
Vetrinary Oncology 6 ( 1 ) 58 - 63 2019.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
Presentations 【 display / non-display 】
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身麻酔中の胃酸逆流により食道狭窄が生じたと疑われる犬の1例
若松周作¹、〇金子泰之¹、岡寺涼太¹、小松原梨可¹、永延清和
第105回日本獣医麻酔外科学会
Event date： 2022.12.24 - 2022.12.25
Language：Japanese Presentation type：Oral presentation (general)
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肝臓血管モデルにより手術シュミレーションを行なった肝内先天性門脈体循環シャントの小型犬の一例
金子 泰之1)、長谷川雅史1) 、山子剛2) 、 山本集士3) 、永延清和1) 、松永美咲1)
第 27 回九州地区日本小動物獣医学会卒後研修会 2022.6.5
Event date： 2022.6.5
Language：Japanese Presentation type：Oral presentation (general)
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国内初となるDomestic cat hepadnavirusの同定
高橋和暉1)、 ◯金子泰之2)、柴内晶子3)、山本集士2)、片桐綾奈3)、大管辰幸4)、井上賀之5)、黒田晃平5)、田邊美加6)、岡林環樹1),7)、永延清和2)、美濃部五三男8)、齊藤暁1),7)
第 27 回九州地区日本小動物獣医学会卒後研修会 2022.6.5
Event date： 2022.6.5
Language：Japanese Presentation type：Oral presentation (general)
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人工腸弁形成により症状改善が認められた短結腸症の犬の１例 Invited
金子泰之, 鳥巣至道, 日高裕貴, 水谷真也, 山本集士, Benedict Huai Ern ONG, 永延清和
第99回日本獣医麻酔外科学会 (大阪国際交流センター) 一般社団法人日本獣医麻酔外科学会
Event date： 2020.1
Language：Japanese Presentation type：Oral presentation (invited, special)
Venue：大阪国際交流センター
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軟部外科 症例検討会 Invited
金子 泰之
第98回日本獣医麻酔外科学会 (大阪国際交流センター) 一般社団法人日本獣医麻酔外科学会
Event date： 2020.1
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
Venue：大阪国際交流センター
Awards 【 display / non-display 】
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第98回獣医麻酔外科学会 軟部組織外科部門 優秀賞
2019.6 第98回獣医麻酔外科学会 人工腸弁形成により症状改善が認められた短結腸症の犬の1例
金子泰之,鳥巣至道，日高裕貴，水谷真也，山本集士，Benedict Huai Ern ONG，永延清和
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第90回獣医麻酔外科学会 軟部組織外科部門 研究発表 優秀賞
2015.6 獣医麻酔外科学会 犬における術中順行性胆道造影の有用性の検討
○金子泰之、鳥巣至道、水谷真也、永延清和
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第55回日本伝統獣医学会大会 理事長賞
2015.6 日本伝統獣医学会 イヌの胆嚢疾患における酸化ストレスの検討
○金子泰之、都築直、橋本千晶、水谷真也、鳥巣至道
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第65回九州地区獣医師大会 フレッシャーアワード
2016.10 第65回九州地区獣医師大会 犬と猫の周術期における血中アンモニア値と血中乳酸値に関する検討
○高橋愛美、鳥巣至道、金子泰之、水谷真也、山本集士、永延清和
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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第61回九州地区獣医師大会 九州地区学会長賞
2012.10 第61回九州地区獣医師大会（宮崎） 牛の立位による腹腔鏡下潜在精巣摘出術の検討
○金子 泰之、鳥巣至道、北原豪、佐藤裕之、日高勇一、大澤健司 、永延清和
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan