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Affiliation |
Faculty of Medicine School of Medicine Department of Internal Medicine, Hematology, Gastroenterology and Hepatology |
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Related SDGs |
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KAWAKAMI Hiroshi
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Degree 【 display / non-display 】
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Doctor (Medicine) ( 2004.3 Hokkaido University )
Papers 【 display / non-display 】
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Ozono Y., Kawakami H., Hatada H., Uchiyama N., Ogawa S., Uchida K., Tamura H., Komaki Y., Nakamura K., Iwakiri H., Hasuike S., Nagata K.
BMC Gastroenterology 26 ( 1 ) 108 2026.12
Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Gastroenterology
Background: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease with increasing global prevalence. Although diabetes is a major factor in NAFLD progression, up to 75% of the patients with NAFLD do not have diabetes. Tofogliflozin (Tofo), a sodium-glucose cotransporter type-2 inhibitor, is widely used in patients with type 2 diabetes. Several clinical trials with Tofo have shown its beneficial effects in NAFLD patients with diabetes; however, currently, there are limited data on NAFLD patients without diabetes. Methods: C57Bl/6J mice were fed a choline-deficient, L-amino acid–defined, high-fat diet (CDAHFD) as a model of non-diabetic non-alcoholic steatohepatitis (NASH). The mice were fed either a normal diet or CDAHFD for 12 weeks, and received either vehicle or Tofo based on their assigned group for 12 weeks. Results: Tofo treatment attenuated CDAHFD-induced liver steatosis and fibrosis. The percentage of monocyte-derived macrophages in the liver, which was significantly increased in the CDAHFD-fed mice, was reduced by Tofo treatment. Furthermore, Tofo treatment increased the hepatic protein and mRNA expression levels related to fatty acid oxidation, which was decreased in CDAHFD-fed mice. Additionally, Tofo treatment decreased the hepatic protein and mRNA expression levels related to fatty acid synthesis, which was increased in CDAHFD-fed mice. Conclusion: Tofo may be a potential candidate for inhibiting liver steatosis and fibrosis via an alternative pathway, unlike glucose metabolism, in NAFLD patients without diabetes.
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Nanashima A., Imamura N., Hiyoshi M., Tsuchimochi Y., Wada T., Hamada T., Suzuki Y., Araki Y., Hosokawa A., Kawakami H.
Cancer Diagnosis and Prognosis 6 ( 2 ) 291 - 302 2026.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Cancer Diagnosis and Prognosis
Background/Aim: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a precursor lesion with variable malignant potential. Due to its heterogeneity, optimal treatment strategies remain controversial, especially regarding surgical resection and surveillance indications. We reviewed our institutional outcomes to reassess the current postoperative strategy and refine management guidelines. Patients and Methods: This study retrospectively and consecutively analyzed the data of 49 IPMN patients who underwent pancreatectomy at an academic institution from 2015 to May 2025. Results: Diagnostic mismatch between preoperative and final pathological findings was observed in 39% of cases, with overdiagnosis (downgrade group) beingmore common than underdiagnosis. Overdiagnosed cases were significantly associated with main pancreatic duct dilation (>5 mm) (p=0.012) and elevated amylase levels (p=0.031), while the only upgraded case involved invasive carcinoma withmural nodule and Sonazoid enhancement. Histological grade strongly influenced prognosis: Patients with adenoma or carcinoma in situ showed favorable outcomes (5-year OS ≥89%), whereas those with invasive IPMN hadmarkedly worse survival (5-year OS 36%; p<0.001). Elevated CA19-9 was a significant negative prognostic factor (p=0.031), while lymph node metastasis (p=0.035) and advanced tumor stage (p=0.0014) were also associated with poor outcomes. Tumors located in the pancreatic tail and those classified as mixed-type IPMN tended to have inferior survival, though without statistical significance. Cancer recurrence occurred in 18% of patients, primarily via peritoneal and hepatic routes. Conclusion: Preoperative diagnostic inaccuracies remain common in IPMN, and invasive transformation, elevated CA19-9, lymph node metastasis, and tumor stage are key prognostic factors. A multimodal diagnostic approach is needed to improve risk stratification and guide appropriate surgical management.
DOI： 10.21873/cdp.10528
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Tanaka Y., Masamune A., Matsumoto R., Takikawa T., Tanaka Y., Hamada S., Miura S., Kume K., Takeyama Y., Kikuta K., Yoshioka R., Yoshimura H., Yoshida N., Yoshida H., Yoshida H., Yoneda K., Yokota T., Yogi T., Yasuda I., Yasuda H., Yashika J., Yamashita S., Yamao K., Yamanouchi K., Yamamoto S., Yamamiya A., Yamagami H., Yamada R., Yamada K., Watanabe S., Urata T., Unno J., Ueno Y., Ueno M., Uchida K., Tuda H., Tsushima K., Tsuruga Y., Tsukamoto Y., Tsukamoto K., Tsujikawa T., Torisu Y., Toki M., Terajima H., Terai S., Tanoue S., Tamoto E., Tamagawa H., Takenaka M., Takasaki Y., Takano Y., Takano S., Takahashi S., Takahashi K., Takahashi K., Takagi T., Takagaki K., Takaesu R., Tabaru A., Suzumura K., Suzuki Y., Suzuki N., Suzuki M., Suzuki K., Suzuki K., Sumida Y., Sumi H., Suenaga S., Suda T., Sogame Y., Sho M., Shirahata N., Shiomi H., Shinohara N., Shinkai T., Shimizu T., Shimatani M., Shiihara M., Shigekawa M., Setsuda M., Sekino Y., Sekine M., Sawai Y., Satoh A., Sato Y., Sato S., Sato M., Satake M., Sasakura Y., Sasaki Y., Sano T., Sakano M., Sakai Y., Sakai T., Saito N., Saito M., Saito K., Saeki A., Oyama T., Otani K.
Journal of Gastroenterology 60 ( 11 ) 1437 - 1448 2025.11
Publishing type：Research paper (scientific journal) Publisher：Journal of Gastroenterology
Objectives: This study aimed to clarify the current clinico-epidemiological characteristics of acute pancreatitis (AP) in Japan. Methods: We conducted a two-stage nationwide survey of patients with AP treated at selected hospitals in 2021, during the COVID-19 pandemic. The first stage estimated the total number of AP patients, while the second collected detailed clinical data. Results: The estimated number of AP patients requiring hospitalization was 61,080, with an overall incidence rate of 49 per 100,000 persons, decreasing from 78,450 in 2016. Detailed clinical data were obtained for 4,375 patients, including 1,362 (31.1%) classified as severe. The male-to-female ratio was 2.0, with mean ages at onset of 60.1 years for males and 65.4 years for females. The three major causes were alcohol (31.2%), gallstones (22.5%), and idiopathic etiology (22.1%). The AP-associated in-hospital mortality rate was 2.1% in all AP and 5.3% in severe cases, down from 6.1% in the 2016 survey. Antibiotics were administered to 61.2% of mild cases, a significant reduction from 94.5% in 2016. Enteral nutrition was provided to 56.9% of severe cases, up from 31.8% in 2016. Among 124 patients undergoing interventional drainage for walled-off necrosis, 57 were treated using a step-up approach. Notably, no patients underwent upfront surgery as the initial treatment. Conclusions: During the pandemic, the estimated number of AP cases requiring hospitalization declined for the first time in nearly four decades. Mortality in severe cases improved, and adherence to clinical guidelines on prophylactic antibiotics and enteral nutrition also improved, indicating enhanced management of AP in Japan.
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Diagnosis of pancreaticobiliary maljunction Reviewed
Kawakami Hiroshi, Hatada Hiroshi, Uchiyama Naomi, Ogawa Souichiro
Tando 39 ( 4 ) 715 - 722 2025.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Biliary Association
Pancreaticobiliary maljunction (PBM) is a congenital malformation in which the pancreatic and bile ducts join anatomically outside the duodenal wall, forming a long abnormal common channel. In PBM, the common channel is longer than normal, which debilitates the effect of the sphincter on the pancreaticobiliary junction, allowing the reciprocal reflux of pancreatic juice and bile. Based on this anatomical abnormality, the reflux of pancreatic juice into the biliary tract (pancreatobiliary reflux) provokes higher rates of biliary cancers, and reflux of bile into the pancreatic duct (biliopancreatic reflux) may sometimes cause pancreatitis. In PBM patients, the gallbladder wall is often thickened, accompanied by epithelial hyperplasia. Ultrasonography (US) is often used as a screening modality. Therefore, US can be used to detect gallbladder wall thickening and intra- and extra-hepatic bile duct dilatation, and can depict the status of the PBM. US plays a key role in the pre-diagnosis of PBM.
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特集 胆膵内視鏡処置具ガイド2025 [私のミニマルセットはこれ!] 結石除去② Reviewed
河上 洋, 内山 尚美, 畑田 紘志
消化器内視鏡 37 ( 10 ) 1310 - 1311 2025.10
Publishing type：Research paper (scientific journal) Publisher：東京医学社
Books 【 display / non-display 】
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NSAIDs in the prevention of post-ERCP pancreatitis
Hiroshi Kawakami, Hiroshi Hatada, Naomi Uchiyama, Souichiro Ogawa, Hiroki Kaneko, Keisuke Uchida, Hotaka Tamura, Yoshinori Ohzono（ Role： Joint author）
2025.4
Language：Japanese Book type：Scholarly book
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Asverse events associated with peroral cholangioscopy and pancreatoscopy
Hiroshi Kawakami, Naomi Uchiyama, Hiroshi Hatada, Souichiro Ogawa, Hotaka Tamura, Yoshinori Ohzono（ Role： Joint author）
2025.3
Language：Japanese Book type：Scholarly book
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成人T細胞白血病/リンパ腫
三池 忠，河上 洋，鈴木 翔，福島 剛（ Role： Joint author）
東京医学社 2024.4
Book type：Scholarly book
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回虫症
河上洋（ Role： Sole author）
医学書院 2022.1
Book type：Textbook, survey, introduction
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Lemmel症候群（傍乳頭憩室症候群）
河上 洋（ Role： Sole author）
日本臨牀社 2019.12
Language：Japanese Book type：Textbook, survey, introduction
MISC 【 display / non-display 】
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TOKYO criteria 2024 for the assessment of clinical outcomes of endoscopic biliary drainage. Reviewed
Isayama H, Hamada T, Fujisawa T, Fukasawa M, Hara K, Irisawa A, Ishii S, Ito K, Itoi T, Kanno Y, Katanuma A, Kato H, Kawakami H, Kawamoto H, Kitano M, Kogure H, Matsubara S, Mukai T, Naitoh I, Ogura T, Ryozawa S, Sasaki T, Shimatani M, Shiomi H, Sugimori K, Takenaka M, Yasuda I, Nakai Y, Fujita N, Inui K for the Research Group of Evaluation Criteria for Endoscopic Biliary Drainage.
Dig Endosc 36 ( 11 ) 1195 - 1210 2024.11
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
DOI： 10.1111/den.14825.
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傍乳頭憩室の病態と合併症 (Lemmel症候群) Invited
河上 洋，畑田 紘志，内山 尚美，小川 宗一郎．
胆と膵 45 ( 特別号 ) 1451 - 1453 2024.11
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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膵管ステントとインドメタシン併用の有無によるERCP後膵炎予防：無作為化非劣性試験．
河上 洋
Gastroenterol Endosc 66 ( 8 ) 1650 - 1650 2024.8
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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成人T細胞白血病 / リンパ腫 Invited
三池 忠，河上 洋，鈴木 翔，福島 剛．
消化器内視鏡 36 ( 4 ) 490 - 491 2024.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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経口胆道鏡・膵管鏡の偶発症 Invited
河上 洋，内山 尚美，畑田 紘志，小川 宗一郎，田村 穂高，内田 圭祐，大園 芳範．
肝胆膵 88 ( 3 ) 307 - 311 2024.3
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
Presentations 【 display / non-display 】
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EUS- guided hepaticogastrostomy（HGS）においてプラスチックステント（PS）は有用である
内山尚美,河上洋,畑田紘志,小川宗一郎,大園芳範
第124回日本消化器病学会九州支部例会/第118回日本消化器内視鏡学会九州支部例会 2024.11.16
Event date： 2024.11.15 - 2024.11.16
Presentation type：Symposium, workshop panel (public)
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切除不能肝細胞癌症例におけるAtezolizumab/Bevacizumab療法の治療成績と予後予測因子についての検討
小牧優里,蓮池悟,永田賢治,河上洋
第124回日本消化器病学会九州支部例会/第118回日本消化器内視鏡学会九州支部例会 2024.11.16
Event date： 2024.11.15 - 2024.11.16
Presentation type：Symposium, workshop panel (public)
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当院における大腸粘膜下層剥離術（ESD）後のpost-electrocoagulation syndrome（PECS）のリスク因子の検討
内田圭祐,鈴木翔,三池忠,黒木大介,河上洋
第124回日本消化器病学会九州支部例会/第118回日本消化器内視鏡学会九州支部例会 2024.11.16
Event date： 2024.11.15 - 2024.11.16
Presentation type：Symposium, workshop panel (public)
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ICI時代のドレナージ戦略について
河上 洋
BTC forum in Nara 2024.11.11
Event date： 2024.11.11
Presentation type：Oral presentation (invited, special)
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A Case of Hepatic Focal Nodular Hyperplasia after Liver Transplantation International conference
Kenichi N,Yoshinori O, Yuri K, Hisayoshi I, Satoru H, Kenji N, Hiroshi K
APASL Oncology 2024 China 2024.9.25
Event date： 2024.9.24 - 2024.9.25
Presentation type：Poster presentation
Awards 【 display / non-display 】
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Digestive Endoscopy Distinguished Reviewers，Recognition in 2022
2023.4 日本消化器内視鏡学会雑誌
Hiroshi Kawakami
Award type：Honored in official journal of a scientific society, scientific journal
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Digestive Endoscopy Best Reviewers Award for 2018
2019.5 日本消化器内視鏡学会
Kawakami H
Award type：Honored in official journal of a scientific society, scientific journal Country：Japan
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Digestive Endoscopy Best Reviewers Award for 2015
2016.4 日本消化器内視鏡学会
Hiroshi Kawakami
Award type：Honored in official journal of a scientific society, scientific journal Country：Japan
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6 th Journal of Gastroenterology High Citation Award 2013
2015.4 日本消化器病学会
河上 洋
Award type：International academic award (Japan or overseas) Country：Japan
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平成26年度北海道大学研究総長賞受賞
2015.3 北海道大学
河上 洋
Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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ＲＢＭ５に結合する抗癌剤感受性制御遺伝子による膵癌の耐性克服治療の開発
Grant number：23591007 2011.04 - 2013.03
科学研究費補助金 基盤研究(C)
RNA結合蛋白RBM5が各種抗癌剤の感受性を高めることを明らかにした．RBM5に結合する抗癌剤感受性制御遺伝子を網羅的に検索し，その機能解析を行った．また，臨床検体におけるRBM5結合性抗癌剤感受性制御遺伝子の発現量と抗癌剤耐性および予後との関連性を検討した．
Other external funds procured 【 display / non-display 】
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Evaluation of biopsies from Vater's ampulla and the bile duct for the diagnosis of autoimmune pancreatitis and cholangitis
2008.04 - 2010.03
Private Foundations
Grant type：Competitive