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Affiliation |
Faculty of Medicine School of Medicine Department of Pathology, Pathophysiology |
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Assistant Professor |
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External Link |
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GIToshihiro
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Papers 【 display / non-display 】
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Histopathological Features of Cancer-Associated Venous Thromboembolism: Presence of Intrathrombus Cancer Cells and Prothrombotic Factors Reviewed International journal
Gi T., Kuwahara A., Yamashita A., Matsuda S., Maekawa K., Moriguchi-Goto S., Sato Y., Asada Y.
Arteriosclerosis, thrombosis, and vascular biology 43 ( 1 ) 146 - 159 2023.1
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Arteriosclerosis, thrombosis, and vascular biology
BACKGROUND: Cancer-associated venous thromboembolism (VTE) is a critical complication in patients with cancer. However, the pathological findings of VTE are limited. Here, we investigated the histopathological features of cancer-associated VTE in human autopsy cases. METHODS: We clinically examined the autopsy cases of VTE with (n=114) and without cancer (n=66) and immunohistochemically analyzed the expression of prothrombotic factors in intrathrombus cancer cells, the thrombus contents of erythrocytes, fibrin, platelets, citrullinated histone H3, and degree of organization. RESULTS: Vascular wall invasion or small cell clusters of cancer cells was observed in thrombi in 27.5% of deep vein thrombosis and 25.9% of pulmonary embolism cases. The majority of the cancer cells in deep vein thrombi appeared to be invading the vessel wall, whereas the majority of pulmonary thrombi had cancer cell clusters, consistent with embolization via blood flow. These cancer cells were immunohistochemically positive for TF (tissue factors) or podoplanin in up to 88% of VTE cases. The frequency of TF-positive monocyte/macrophages in thrombi was higher in cancer-associated VTE than that in VTE without cancer. Citrullinated histone H3 was predominantly observed in the early stages of organizing thrombi. There was no significant difference in thrombus components between VTE with cancer and without cancer groups. CONCLUSIONS: Vascular wall invasion or cancer cell clusters in thrombi might influence thrombogenesis of cancer-associated VTE. TF and podoplanin in cancer cells and in monocyte/macrophages may induce coagulation reactions and platelet aggregation. Neutrophil extracellular traps may play a role in the early stages of VTE, regardless of cancer status.
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症例 ペムブロリズマブによる免疫関連有害事象と考えられたHypertrophic Lichen Planusの1例 Invited
後田 優香, 西川 陽太郎, 野海 健太, 魏 峻洸, 天野 正宏
皮膚科の臨床 65 ( 12 ) 1896 - 1899 2023.11
Language：Japanese Publishing type：Case report Publisher：金原出版
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Soejima H., Ogawa H., Morimoto T., Okada S., Matsumoto C., Nakayama M., Masuda I., Jinnouchi H., Waki M., Saito Y., Miwa K., Akahoshi K., Misumi K., Araki H., Mitsudo Y., Kondo N., Ashihara K., Yumoto S., Horimoto M., Doi O., Doijiri K., Fukami R., Shimabukuro M., Egusa G., Goto K., Hanaoka Y., Kimura Y., Haraguchi Y., Haraguchi O., Hasegawa A., Shioya Y., Shioya Y., Tanaka E., Yamada K., Atsumi T., Tanazawa S., Horio Y., Ichihara S., Yasuda I., Ikeda T., Ikemura M., Imamoto C., Iseri Y., Iwai K., Okamoto S., Sugiyama S., Kamura M., Kan H., Kiyota M., Kawamura K., Ono T., Koga T., Kinuwaki E., Naito H., Kozuma K., Kudou K., Morikami Y., Yasue H., Mizuno Y., Fujimoto H., Matsuyama K., Fujii H., Kamijikkoku S., Kuwahara T., Takaoka K., Machii K., Maeda K., Mahara K., Maki A., Manda N., Marutsuka K., Sameshima N., Gi T., Matsunaga T., Matsuo S., Okubo H., Minagawa F., Minoda K., Miyata J., Matsuo T., Momosaki S., Munakata T., Nakamura T., Nagano H., Goshi K., Sugimoto K., Naomi S., Nasu T., Tanaka H., Sonoda R., Kajiwara K., Odo T., Ogata H., Ogihara M., Ogura T., Oka K., Kawashima E., Oshima E., Ozaki K., Ozawa S.
Heart and Vessels 38 ( 11 ) 1371 - 1379 2023.11
Publishing type：Research paper (scientific journal) Publisher：Heart and Vessels
Background: Dipeptidyl Peptidase-4 (DPP-4) inhibitors do not suppress cardiovascular events in diabetic patients with a history of cardiovascular disease. However, the effect of DPP-4 inhibitors on cardiovascular events in Japanese diabetic patients is unclear. Therefore, we investigated whether DPP-4 inhibitors alter the incidence of cardiovascular events in Japanese diabetic patients without a history of cardiovascular events. Methods: The Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial was a multicenter, prospective, randomized, open label, blinded, end-point study conducted from 2002 to 2008. After completion of the JPAD trial, we followed up the patients until 2019. Patients who had had a cardiovascular event by the 2013 follow-up were excluded from the study. JPAD patients were divided into a DPP-4 group and a non-DPP-4 group based on whether they were taking DPP-4 inhibitors at the 2013 follow-up because few patients took DPP-4 inhibitors before 2013. We investigated the incidence of cardiovascular events consisting of coronary events, cerebrovascular events, heart failure requiring hospitalization, and aortic and peripheral vascular disease in 1099 JPAD patients until 2019. Results: During the observation period from 2013 to 2019, 37 (7%) first cardiovascular events occurred in the DPP-4 group (n = 518) and 66 (11%) in the non-DPP-4 group (n = 581). The incidence of cardiovascular events was significantly lower in the DPP-4 group than in the non-DPP-4 group (Log-Rank P = 0.0065). Cox proportional hazards model analysis revealed that the use of DPP-4 inhibitors (hazard ratio 0.65; 95% confidence interval 0.43–0.98; P = 0.038) was an independent factor after adjustment for age ≥ 65 years, hypertension, statin usage, and insulin usage. Conclusions: Our findings have demonstrated that the use of DPP-4 inhibitors may be associated with a reduced incidence of first cardiovascular events in Japanese diabetic patients. The results require confirmation in randomized controlled trials.
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Shimazu H., Matsuura Y., Moribayashi K., Gi T., Suiko Y., Tanaka H., Komaki S., Ishikawa T., Yamashita A., Kaikita K.
JACC: Case Reports 24 102017 2023.10
Language：English Publishing type：Case report Publisher：JACC: Case Reports
Immune thrombocytopenia (ITP) carries bleeding and thrombotic risks; however, thromboses associated with ITP have not been histologically examined. This report presents optical coherence tomography images of the culprit lesion and histology of coronary aspirates in very late stent thrombosis complicating severe ITP, providing evidence of platelet-rich thrombus formation. (Level of Difficulty: Advanced.)
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Magnetic Resonance Imaging of Cancer-Associated Deep Vein Thrombus in a Patient With Gastric Cancer Reviewed
Gi Toshihiro, Kuroiwa Yasuyoshi, Kihara Yasushi, Miyaushiro Sae, Yamashita Atsushi
Circulation Reports 5 ( 6 ) 265 - 266 2023.6
Authorship：Lead author Language：English Publishing type：Case report Publisher：The Japanese Circulation Society
Books 【 display / non-display 】
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モデル動物の作製と利用 循環器疾患 2021 上巻
山下 篤, 魏 峻洸, 浅田 祐士郎（ Role： Contributor , 第4節 ウサギ反復傷害血栓モデル）
株式会社 エル・アイ・シー 2021.9
Language：Japanese Book type：Textbook, survey, introduction
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New Textbook of clinical Phlebology
（ Role： Contributor）
2019.10
Total pages：503 Responsible for pages：398-399 Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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がんの種類別に見たCATのエビデンス 癌関連静脈血栓塞栓症の病理組織学的解析
魏 峻洸, 山下 篤, 松田 俊太郎, 佐藤 勇一郎, 浅田 祐士郎
脈管学 60 ( Suppl. ) S93 - S94 2020.10
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本脈管学会
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破裂性冠動脈プラークの血小板粘着にフィブリンやフォンウィルブランド因子が関与する
山下 篤, 西平 賢作, 前川 和也, 魏 峻洸, 畠山 金太, 柴田 剛徳, 浅田 祐士郎
日本血栓止血学会誌 31 ( 2 ) 247 - 247 2020.5
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本血栓止血学会
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剖検例を用いた癌関連静脈血栓塞栓症の病理組織学的検討
魏 峻洸, 山下 篤, 松田 俊太郎, 佐藤 勇一郎, 浅田 祐士郎
日本血栓止血学会誌 31 ( 2 ) 247 - 247 2020.5
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本血栓止血学会
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グルタミンは血管平滑筋細胞の凝固活性を抑制する
小山彰平, 山下篤, 松浦祐之介, 齋藤祐介, 前川和也, 魏峻洸, 北村和雄, 海北幸一, 浅田祐士郎
日本動脈硬化学会総会・学術集会プログラム・抄録集(Web) 54th 2022
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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From the Winners of Freshman Researcher Award Commemorative of Japanese Society of Pathology 100th Anniversary Invited
Toshihiro Gi
Pathology and Clinical Medicine 39 ( 10 ) 2021.11
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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閉塞性細気管支炎により慢性肺移植片機能不全をきたした一剖検症例
魏 峻洸, 重草 貴文, 坪内 宏伸, 松元 信弘, 山下 篤, 前川 和也, 阿萬 紫, 佐藤 勇一郎, 鍋島 一樹, 浅田 祐士郎
日本病理学会会誌 2018.10 (一社)日本病理学会
Event date： 2018.10
Language：Japanese Presentation type：Oral presentation (general)
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深部静脈血栓症における拡散強調画像の有用性:家兎頚静脈血栓モデルを用いた検討
黒岩靖淳, 黒岩靖淳, 魏峻洸, 山下篤, 圓崎将大, 小西祐子, 宮地利明, 平井俊範, 今村卓郎, 浅沼武敏, 浅田祐士郎
日本血栓止血学会誌 2017.4.1
Event date： 2017.4.1
Language：Japanese Presentation type：Oral presentation (general)
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血管内皮細胞のPodoplanin発現はラット頸動脈におけるびらん性傷害と血栓形成を促進する
古小路英二, 山下篤, 盛口清香, 前川和也, 魏峻洸, 佐藤勇一郎, 平井俊範, 浅田祐士郎
日本血栓止血学会誌 2017.4.1
Event date： 2017.4.1
Language：Japanese Presentation type：Oral presentation (general)
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Title] Multiple coronary plaque ruptures in an autopsy case of acute myocardial infarction
2021.11.4
Event date： 2021.11.4 - 2021.11.5
Language：Japanese Presentation type：Poster presentation
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心臓 MRI での病変の不均一性を呈した AL アミロイドーシスに対して両心室心筋生検を行った一例
山村善政, 松浦祐之介, 石川哲憲, 北村和雄, 魏峻洸, 浅田祐士郎
第42回心筋生検研究会学術集会 2021.6.12
Event date： 2021.6.12
Language：Japanese Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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日本病理学会100周年記念 病理学研究新人賞
2021.4 日本病理学会 血栓症の病態解明と新規検出法の開発
魏 峻洸
Award type：Award from Japanese society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
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肺血栓塞栓症における非塞栓部肺動脈の変化と静脈血栓由来因子の解明
Grant number：23K06467 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究（C）
山下 篤
Authorship：Coinvestigator(s)
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重症熱性血小板減少症候群における血小板減少と血液凝固異常の病態解明
Grant number：23K06425 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究（C）
盛口 清香
Authorship：Coinvestigator(s)
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妊産婦死亡の主因である羊水塞栓症における血栓性病態の解明
Grant number：22K06961 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
阿萬 紫、
Authorship：Coinvestigator(s)
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癌関連静脈血栓症の血栓形成機序と発症予測所見の解明
Grant number：21K15403 2021.04 - 2024.03
日本学術振興会 科学研究費助成事業 若手研究 若手研究
魏 峻洸
Authorship：Principal investigator