論文 - 魏 峻洸
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Nakamura E, Sato Y, Iwakiri T, Yamashita A, Moriguchi-Goto S, Maekawa K, Gi T, Asada Y
Journal of atherosclerosis and thrombosis 2017年9月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 日本動脈硬化学会
<b><i>Aim</i></b>: Patients with peripheral artery disease (PAD) have a high prevalence of cardiovascular morbidity and mortality; however, majority of patients with PAD are asymptomatic. This study aimed to histologically evaluate whether asymptomatic, lower extremity artery plaques are associated with systemic atherosclerosis and the onset of cardiovascular disease (CVD) events using autopsy cases.<b><i>Methods</i></b>: We histologically investigated the atherosclerotic plaques of the common iliac, common carotid, coronary, and renal arteries from 121 autopsy cases without symptoms of PAD (mean age:67.6 years; 63% men; 83% non-CVD death). We evaluated the relationship between the degree of iliac artery atherosclerosis and that of other arteries, and also the presence of any CVD, myocardial infarction, stroke, and renal failure.<b><i>Results</i></b>: Advanced atherosclerotic plaques (American Heart Association ≥4) were present in 86 (72%) common iliac arteries in these cases. These arteries also showed high frequencies of calcification (66%), intraplaque hemorrhage (42%), and plaque disruption (24%). These advanced lesions were associated with age (≥60 years), sex (male), hypertension, diabetes, and smoking habit (all <i>P</i><b>＜</b>0.05). Additionally, it was significantly associated with CVD (odds ratio, 95% confidence interval; 6.2, 2.2–22), myocardial infarction (6.4, 1.2–19), stroke (8.7, 1.7–16), and renal failure/hemodialysis (5.8, 1.1–11). Cases with advanced iliac artery plaques had advanced coronary and carotid atherosclerosis.<b><i>Conclusion</i></b>: These results indicate that asymptomatic advanced plaques are frequently observed in common iliac arteries, and are associated with generalized atherosclerosis and CVD events.
DOI： 10.5551/jat.39669
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傍糸球体細胞腫の1例 査読あり
中村 恵理子, 山下 篤, 魏 峻洸, 前川 和也, 盛口 清香, 佐藤 勇一郎, 北 俊弘, 佐藤 俊介, 浅田 祐士郎
診断病理 34 ( 3 ) 247 - 251 2017年7月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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子宮体下部(峡部)に発生した類内膜腺癌の1例 査読あり
佐藤勇一郎, 盛口清香, 山下篤, 前川和也, 中村恵理子, 魏峻洸, 福島和子、大西淳仁, 川越靖之, 鮫島浩, 浅田祐士郎
日本婦人科病理学会誌 2017年6月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Microvascular proliferation of brain metastases mimics glioblastomas in squash cytology 査読あり
Gi T., Sato Y., Tokumitsu T., Yamashita A., Moriguchi-Goto S., Takeshima H., Sato S., Asada Y.
Cytopathology 28 ( 3 ) 228 - 234 2017年6月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Cytopathology
© 2016 John Wiley & Sons Ltd Objective: Although microvascular proliferation is a key feature in the diagnosis of high-grade glioma, the characteristics of metastatic tumour vessels in smear preparations have not been documented. In this study, the vascular changes in metastatic brain tumours, using squash cytology to examine the vascular patterns in brain metastases, were reviewed. Methods: One hundred and forty-three squash smears of brain tissue, including 25 normal or reactive tissue, 23 malignant lymphomas, 8 grade I glioma (pilocytic astrocytoma), 23 grade II glioma (diffuse astrocytoma and oligodendroglioma), 42 grade IV glioma (glioblastoma), and 22 metastasis, were assessed. Two vascular patterns were assessed: thick and branching, and glomeruloid. The vessel density, nuclear layer and the number of vessel branches were compared. Furthermore, tumour vessels of brain metastases were analysed by histology and for immunohistochemical expression of CD34, α-smooth muscle actin (SMA) and high-molecular-weight caldesmon (h-CD). Results: Among 22 metastatic tumours, thick and branching vessels were found in 17 (77%) and glomeruloid vessels in 13 (59%). These incidences of microvascular proliferation patterns were similar to those of glioblastomas or pilocytic astrocytomas. Vessel density, nuclear layer and vessel wall branches were significantly higher in metastatic tumours than malignant lymphomas, grade II gliomas or normal brain tissues. Glomeruloid vessels consisted of CD34-positive cells and α-SMA-positive cells, and α-SMA-positive cells had a low h-CD expression. These immunohistochemical patterns were similar to those of high-grade gliomas. Conclusions: The vascular features of metastatic brain tumours are similar to those of glioblastomas, suggesting that these microvascular proliferations contribute to the progression of metastatic tumours.
DOI： 10.1111/cyt.12405
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Hida R., Yamamoto H., Hirahashi M., Kumagai R., Nishiyama K., Gi T., Esaki M., Kitazono T., Oda Y.
American Journal of Surgical Pathology 41 ( 3 ) 343 - 353 2017年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：American Journal of Surgical Pathology
© 2016 Wolters Kluwer Health, Inc. All rights reserved. Duodenal neoplasm of gastric phenotype (DNGP) is very rare, and details of its histopathologic, genetic, and biological features are still unclear. Frequent gene mutations in GNAS, KRAS, and APC have been reported in pyloric gland adenomas and fundic gland-type neoplasms (initially reported as low-grade adenocarcinomas) of the stomach. Here we retrospectively analyzed 16 cases of extra-ampullary DNGP (benign to malignant), and we examined the mucin immunoprofile and oncogene mutations (GNAS, KRAS, APC, BRAF, and CTNNB1). The 16 DNGPs were histologically classified into adenomas (5 pyloric gland adenomas and 2 foveolar-type adenomas), neoplasms of uncertain malignant potential (NUMPs, n=6), and invasive adenocarcinomas (n=3). NUMPs consisted of slightly atypical epithelial cells with pale, eosinophilic, or basophilic cytoplasm growing in an anastomosing or branching glandular pattern, often with expansive submucosal extension. In contrast to invasive adenocarcinomas, NUMPs lacked significant nuclear irregularity, desmoplastic stromal reaction, lymphovascular invasion, and metastasis; their features were reminiscent of fundic gland-type neoplasms of the stomach. Immunophenotypically, most of NUMPs were predominantly positive for MUC6 with variable expressions of pepsinogen-I, H + K + ATPase, human gastric mucin, and MUC5AC. Molecular analyses reve aled the gene mutations of GNAS in 6 (38%) of 16 DNGPs (4 [57%] adenomas, 1 [16%] NUMP, and 1 [33%] invasive adenocarcinoma) and APC in 4 of 15 (27%) DNGPs: no adenomas, 2 (33%) NUMPs, and 2 (67%) invasive adenocarcinomas. BRAF mutation was present in only 1 (16%) NUMP, and KRAS and CTNNB1 mutations were absent. In conclusion, gastric-phenotype adenomas and NUMPs of the duodenum are similar to their counterparts of the stomach, in terms of histologic, genetic, and clinicopathologic features. We propose the term "NUMP" as an intermediate category between adenoma and definitely invasive adenocarcinoma. Our findings may provide novel insights into the classification of undescribed but distinctive duodenal tumors showing similarity to gastric-phenotype neoplasms of the stomach.
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Furukoji E., Gi T., Yamashita A., Moriguchi-Goto S., Kojima M., Sugita C., Sakae T., Sato Y., Hirai T., Asada Y.
Thrombosis Journal 14 ( 1 ) 46 2016年11月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Thrombosis Journal
© 2016 The Author(s). Background: Thrombolytic therapy is effective in selected patients with deep vein thrombosis (DVT). Therefore, identification of a marker that reflects the age of thrombus is of particular concern. This pilot study aimed to identify a marker that reflects the time after onset in human aspirated DVT. Methods: We histologically and immunohistochemically analyzed 16 aspirated thrombi. The times from onset to aspiration ranged from 5 to 60days (median of 13days). Paraffin sections were stained with hematoxylin and eosin and antibodies for fibrin, glycophorin A, integrin α2bβ3, macrophage markers (CD68, CD163, and CD206), CD34, and smooth muscle actin (SMA). Results: All thrombi were immunopositive for glycophorin A, fibrin, integrin α2bβ3, CD68, CD163, and CD206, and contained granulocytes. Almost all of the thrombi had small foci of CD34- or SMA-immunopositive areas. CD68- and CD163-immunopositive cell numbers were positively correlated with the time after onset, while the glycophorin A-immunopositive area was negatively correlated with the time after onset. In double immunohistochemistry, CD163-positive cells existed predominantly among the CD68-immunopositive macrophage population. CD163-positive macrophages were closely localized with glycophorin A, CD34, or SMA-positive cell-rich areas. Conclusions: These findings indicate that CD163 macrophage and erythrocyte contents could be markers for evaluation of the age of thrombus in DVT. Additionally, CD163 macrophages might play a role in organization of the process of venous thrombus.
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悪性度の診断に苦慮した悪性Brenner腫瘍の1例. 査読あり
魏 峻洸, 佐藤勇一郎, 村岡純輔, 福島和子, 川越靖之, 鮫島浩, 浅田祐士郎
日本婦人科病理学会誌 7 ( 1 ) 17 - 19 2016年
記述言語：日本語 掲載種別：研究論文（学術雑誌）