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Affiliation |
Faculty of Agriculture Department of Veterinary Science |
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Title |
Assistant Professor |
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External Link |
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INOUE Yoshiyuki
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Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
Papers 【 display / non-display 】
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Mizutani Y., Inoue Y., Goda Y., Mizutani S., Asanuma T., Miura N., Hidaka Y., Sato R., Satoh H.
Veterinary Sciences 10 ( 9 ) 2023.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Veterinary Sciences
Of intracranial tumors, primary central nervous system lymphoma (PCNSL) is rare in dogs. Herein, we describe our experience with two dogs (a 3-year-old intact female toy poodle and a 5-year-old spayed female toy poodle) that developed neurological symptoms. Magnetic resonance imaging (MRI) revealed intracranial disseminated lesions. Cerebrospinal fluid (CSF) examination revealed pleocytosis and B-cell monoclonal proliferation in both cases. PCNSL or secondary central nervous system lymphoma (SCNSL) was diagnosed on the basis of MRI findings and CSF examinations. Nimustine (ACNU) is a nitrosourea alkylating agent, a class of drugs that includes lomustine. Nimustine is mainly used to treat human intracranial neoplasia because of its high permeability across the blood-brain barrier. The dogs in this study were treated with combined chemotherapy comprising nimustine and prednisolone, which achieved complete or nearly complete remission of neurological symptoms and long-term survival (>2583 days and 1218 days), but with problematic adverse effects. We determined that the dose of nimustine for canine PCNSL or SCNSL with intravenous infusion was 25–30 mg/m2 every 3–4 weeks for a total of four times; however, the data were insufficient to determine the optimal regimen.
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A retrospective analysis for criteria of surgical intervention in Japanese Black calves with respiratory signs caused by perinatal rib fracture Reviewed
2023.1
Language：English Publishing type：Research paper (scientific journal)
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Clinical Diagnosis of Lymphedema in a Japanese Black Calf by Lymphangiography
TSUCHIMOTO Ayaka, KIRINO Yumi, YAMAUCHI Shino, SATOH Hiroyuki, YASUDA Masahiro, HIRAI Takuya, INOUE Yoshiyuki, HIDAKA Yuichi
Journal of the Japan Veterinary Medical Association 76 ( 9 ) e208 - e212 2023
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Veterinary Medical Association
An eight-month-old, female Japanese Black calf weighing 213 kg showed bilateral hindlimb edema of unknown origin. The animal had no abnormalities in general condition and gait. As a result of a blood check, the presence of underlying diseases developing edema were not suspected. Clinical examinations and diagnostic treatments in this case eliminated systemic diseases including cardiac and nutritional disorders or regional inflammation and peripheral vascular disease as causes for the bilateral edema, but it was speculated to be due to a partial lymph flow disturbance. Lymphangiography was performed using an iodine based oily contrast medium, and the contrast medium was injected subcutaneously in the carpus and tarsus regions in both forelimbs and both hindlimbs. Sequential radiographs showed an inflow of the contrast medium into the lymphatics of both forelimbs, but not of both hindlimbs. Based on these findings, this calf was clinically diagnosed with lymphedema, and pathological examination confirmed the disease.
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Intra-abdominal mass containing controlled internal drug release (CIDR) devices detected by CT in a Japanese Black cow Reviewed
Reiichiro SATO, Hiroyuki SATOH, Shoichi OKADA, Yoshimichi GODA, Kim SUEUN, Kohei KURODA, Yoshiyuki INOUE, Go KITAHARA, Takeshi OSAWA
Journal of Veterinary Medical Science 2022.8
Publishing type：Research paper (scientific journal)
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Surgical Treatment of a Retropharyngeal Abscess in a Japanese Black Cow Reviewed
Okada S., Sueun K., Ichikado R., Kuroda K., Inoue Y., Nakama Y., Satoh H., Sato R.
Veterinary Sciences 9 ( 8 ) 2022.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Veterinary Sciences
A 17-month-old Japanese Black cow presented with inappetence, wheezing, dysphagia, and drooling. Radiography and ultrasonography revealed an oval, dorsal, pharyngeal mass, with an internal horizontal line demarcating the radiolucent area from the radio-opaque area. Upper airway endoscopy revealed pus-like deposits in the dorsal nasal passage, hyperemia, and edema in the dorsal pharynx, leading to swelling and airway obstruction. Manual palpation, after sedation, revealed a thickened mass surface, which was difficult to rupture with manual pressure. After inserting a linear sonographic probe through the mouth to establish the vascularity surrounding the mass and to identify a relatively thin-walled area, a trocar was pierced into the mass under endoscopic guidance, and the opening was enlarged manually. The mass was filled with stale pus-like material, which was removed manually. The abscess cavity was washed using saline and povidone–iodine. Day 1 post-surgery, dysphagia and wheezing disappeared. Day 16 post-surgery, endoscopy showed significant improvement in the airway patency. One year postoperatively, the owner reported that the cow had an uneventful recovery. For deep abscesses, such as bovine pharyngeal abscesses, it is important to perform a preoperative transoral Doppler ultrasonography to assess the vascularity and thickness of the abscess wall for safe trocar insertion and abscess drainage.
MISC 【 display / non-display 】
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KIM Sueun, NAIK Mrunmayi Vishwanath, KIRINO Yumi, SATOH Hiroyuki, TSUZUKI Nao, INOUE Yoshiyuki, KURODA Kohei, HIDAKA Yuichi
Journal of Veterinary Medical Science 85 ( 1 ) 40 - 43 2023.1
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
Medical records of 16 Japanese Black calves with respiratory signs associated with perinatal rib fracture were analyzed, retrospectively, to speculate criteria of surgical intervention for the disease. For this analysis, the severity of respiratory condition was classified into three grades: Grade 1, with no wheezing, Grade 2, with wheezing after excitement but not at rest and Grade 3, with wheezing at rest. Grade 1 (n=3) received only conservative management. Seven of Grade 2 (n=8) and all of Grade 3 (n=5) had surgical management. Clinical outcome was good in all of Grade 1, and the surgical success rate was 83% in other groups. Our result suggests that surgical intervention should be considered for cases with more the severity of Grade 2.
DOI： 10.1292/jvms.22-0332
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Repair of a calcaneal fracture with a combination of internal and external fixation in a calf
INOUE Yoshiyuki, MOGI Wataru, NAIK Mrunmayi Vishwanath, KIM Sueun, KIRINO Yumi, HIDAKA Yuichi, SATO Reiichiro
Journal of Veterinary Medical Science 85 ( 7 ) 739 - 742 2023
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
A 6-day-old male Japanese Black calf presented with a transverse fracture of the left calcaneus. In calcaneal fractures, traction of the gastrocnemius muscle causes substantial displacement of the proximal fracture fragment; therefore, external fixation alone is prone to failure of fusion or deformed fusion. Furthermore, internal fixation alone may result in refracture due to the high load on the implant. Therefore, internal and external fixation were used to treat the fracture. Bone fusion was observed on postoperative day 50; the wire was removed on postoperative day 90. Radiographic examination at 4 months postoperatively revealed that the bone had fused in normal alignment. Therefore, a good prognosis can be expected for calcaneal fractures treated with combined internal and external fixation.
DOI： 10.1292/jvms.23-0167
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Identification of domestic cat hepadnavirus from a cat blood sample in Japan
TAKAHASHI Kazuki, KANEKO Yasuyuki, SHIBANAI Akiko, YAMAMOTO Shushi, KATAGIRI Ayana, OSUGA Tatsuyuki, INOUE Yoshiyuki, KURODA Kohei, TANABE Mika, OKABAYASHI Tamaki, NAGANOBU Kiyokazu, MINOBE Isao, SAITO Akatsuki
Journal of Veterinary Medical Science 84 ( 5 ) 648 - 652 2022.5
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
The hepatitis B virus (<i>Hepadnaviridae</i>) induces chronic hepatitis and hepatic cancer in humans. A novel domestic cat hepadnavirus (DCH) was recently identified in several countries, however, the DCH infection status of cats in Japan is unknown. Therefore, we investigated the DCH infection rate of 139 cat samples collected in Japan. We identified one positive blood sample (0.78%) from a 17-year-old female cat with chronically elevated alanine aminotransferase. Phylogenetic analysis demonstrated that the DCH strain identified in this study is genetically different from strains in other countries. Further investigations are required to elucidate the evolution of DCH and the impact of DCH infection on hepatic diseases in domestic cats.
DOI： 10.1292/jvms.22-0010
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SATO Reiichiro, SATOH Hiroyuki, OKADA Shoichi, GODA Yoshimichi, SUEUN Kim, KURODA Kohei, INOUE Yoshiyuki, KITAHARA Go, OSAWA Takeshi
Journal of Veterinary Medical Science 84 ( 8 ) 1088 - 1092 2022
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
<p>This report describes an intra-abdominal mass caused by progesterone-containing controlled internal drug release (CIDR) devices in the abdominal cavity of a 28-month-old Japanese Black heifer presenting with infertility. Rectal examination revealed a mass containing a cartilage-like object in the pelvic cavity. Computed tomography revealed a mass containing two T-shaped foreign bodies. Laparotomy was performed to remove the mass containing the foreign bodies. The heifer was healthy at discharge seven days post-surgery. This case adds CIDR device as a new etiology for intra-abdominal masses. Furthermore, it highlights the usefulness of CT in diagnosing deep abdominal lesions.</p>
DOI： 10.1292/jvms.22-0180
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NAIK Mrunmayi Vishwanath, NISHIKAWA Goa, KIRINO Yumi, INOUE Yoshiyuki, IWAMOTO Kio, YAMABE Ryusei, NAKAYAMA Toshie, TSUZUKI Nao, HIDAKA Yuichi
Journal of Veterinary Medical Science 82 ( 2 ) 204 - 208 2020
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
Two-month-old (Case 1) and one-year-old (Case 2) Japanese Black cattle presented with bilateral rostral mandibular open fractures. At presentation, the proximal edges of each fracture were discolored and had a severe stench, indicating necrosis caused by infection. In both cases, a bilateral rostral mandibulectomy over the symphysis was performed. Although the tongues of both animals prolapsed post-surgery, they had no significant problems with eating or drinking. Case 1 showed excellent growth during fattening, and Case 2 successfully became pregnant and gave birth. Rostral mandibulectomy can be an effective surgical option for the treatment of cattle with difficulty in internal or external fixation due to unfavorable necrotic cranial mandibular open fractures.
DOI： 10.1292/jvms.19-0160
Presentations 【 display / non-display 】
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頸部腹側減圧術単独で治療した頸部椎間板ヘルニアの小型犬30症例に対する回顧的検討
井上賀之、黒田晃平、山中隆人、佐藤裕之、五田嘉倫、日高勇一
令和5年度獣医学術九州地区学会 2023.9.10
Event date： 2023.9.10
Presentation type：Oral presentation (general)
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椎体間ケージで腹側椎体固定術を実施したHansenⅡ型頸部椎間板ヘルニアの小型犬2例
井上賀之、黒田晃平、近藤瑞保、松岡瑞穂、佐藤裕之、五田嘉倫、日高勇一
令和5年度獣医学術九州地区学会 2023.9.10
Event date： 2023.9.10
Presentation type：Oral presentation (general)
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スエヒロタケ（Schizophyllum commune）による真菌性脊椎炎に伴い両後肢麻痺を呈した犬の1例
井上賀之、水谷祐子、佐藤裕之、村田佳輝、二瓶和美、田邊美加、日高勇一
第106回 日本獣医麻酔外科学会学術集会 2023.6.18
Event date： 2023.6.16 - 2023.6.18
Presentation type：Oral presentation (general)
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Zurich mini cementless total hip systemを用いて股関節全置換術を実施したレッグ・カルベ・ペルテス病の犬の１例
井上賀之、佐藤裕之、黒田晃平、日高勇一
第28回九州地区日本小動物獣医学会卒後研修会 2023.6.4
Event date： 2023.6.4
Presentation type：Oral presentation (general)
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椎体間ケージ単独で腹側固定を実施したウォブラー症候群の犬の1例
井上賀之、佐藤裕之、黒田晃平、日高勇一
第28回九州地区日本小動物獣医学会卒後研修会 2023.6.4
Event date： 2023.6.4
Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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小動物獣医学会フレッシャーアワード
2023.9 日本小動物獣医学会 椎体間ケージで腹側椎体固定術を実施したHansenⅡ型頸部椎間板ヘルニアの小型犬2例
井上賀之、黒田晃平、近藤瑞保、松岡瑞穂、佐藤裕之、五田嘉倫、日高勇一
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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坂本紘賞
2023.6 九州地区日本小動物獣医学会、日本獣医麻酔外科学会 椎体間ケージ単独で腹側固定を実施したウォブラー症候群の犬の1例
井上賀之、佐藤裕之、黒田晃平、日高勇一
Award type：Award from Japanese society, conference, symposium, etc.
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小動物獣医学会フレッシャーアワード
2019.11 日本小動物獣医学会
井上賀之,土本彩花,水谷真也,水谷祐子,Naik Mrunmayi Vishwanath,坂井秀二,桐野有美,日高勇一
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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産業動物獣医学会九州獣医師連合会会長賞
2019.11 日本産業動物獣医学会 内固定および外固定を併用して治療した踵骨骨折の黒毛和種子牛の１例
井上賀之,加藤梨帆,茂木渉,Naik Mrunmayi Vishwanath,Kim Su Eun,桐野有美,日高 勇一
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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日本産業動物獣医学会九州地区連合会長賞
2017.10 日本獣医産業動物獣医学会 両側下顎骨開放骨折に対し吻側下顎骨切除術を行った黒毛和種子牛の１例
西川豪亜, 日高勇一, 岩本希生, Naik Mrunmayi Vishwanath, 山部竜正, 都築 直, 桐野有美, 井上賀之
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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新規ペプチド“NURP”と“NSRP”のトランスレーショナルリサーチ
Grant number：20H03153 2020.04 - 2024.03
日本学術振興会 科学研究費助成事業 基盤研究(B) 基盤研究(B)
中原 桂子, 丸山 圭介, 永延 清和, 井上 賀之
Authorship：Coinvestigator(s)
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Neuromedin U/Sとそれらの新規関連ペプチドの機能探索および橋渡し研究
Grant number：18H02354 2018.04 - 2021.03
日本学術振興会 科学研究費助成事業 基盤研究(B) 基盤研究(B)
村上 昇, 井上 賀之, 中原 桂子
Authorship：Principal investigator
昨年に掲げた研究実施計画は、NMU,NMS, NURPおよびNSRPの4つのペプチドの作用部位の違いを明確にすることであった。その方法としては、それら４つのペプチドをラットの脳室内に投与し、投与後のcFos発現を蛍光免疫染色によって比較することを掲げた。その結果、NMU及びNMS投与群では、室傍核、視索上核、扁桃体中心核で顕著に多いcFos発現が認められたのに対し、NURP及びNSRP投与群では、視交叉上核、視索上核、扁桃体中心核でのcFos発現は認められなかった。弓状核ではどのペプチド投与群においてもcFos発現がみられたが、その領域は異なっており、NMU、NMS投与では弓状核内側領域で、NURP、NSRP投与では弓状核外側領域で発現が認められた。また、NURP投与群でのみ腹側海馬台においてcFos発現が認められた。さらに、視床下部前領域ではNSRP投与群で発現量が多く、動眼神経副核ではNMS投与群で発現量が多い傾向がみられた。NMU、NMSが同様の部位にcFos発現を示したのは、両者が同じ受容体のNMU-R1、R2に結合している結果であると思われる。一方で、NMUとNMSの前駆体中の新規ペプチドのNURPとNSRPはそれらと異なる作用部位に作用していることが推測された。さらにNURPとNSRPが同じような作用部位を示したことは、それらの分子のアミノ酸配列に一部ホモロジーの高い部位が存在するためと考えられる。しかし、腹側海馬台において両者が異なっていたことから、それぞれが別の受容体を有している可能性も否定できないとも考えられる。
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デスアシルグレリンの新規生理作用の探索ならびに受容体の同定
Grant number：11J07865 2011.04 - 2013.03
独立行政法人日本学術振興会 科学研究費補助金 特別研究員奨励費