井上 賀之 (イノウエ ヨシユキ)

INOUE Yoshiyuki

写真a

所属

農学部 獣医学科

職名

助教

外部リンク

学位 【 表示 / 非表示

  • 獣医学博士 ( 2013年3月   山口大学 )

研究分野 【 表示 / 非表示

  • ライフサイエンス / 獣医学

 

論文 【 表示 / 非表示

  • Bilateral rostral mandibulectomy for treatment of necrotic mandibular open fractures in two Japanese Black cattle. 査読あり

    Naik MV, Nishikawa G, Kirino Y, Inoue Y, Iwamoto K, Yamabe R, Nakayama T, Tsuzuki N, Hidaka Y

    The Journal of veterinary medical science   82 ( 2 )   204 - 208   2020年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:公益社団法人 日本獣医学会  

    <p>Two-month-old (Case 1) and one-year-old (Case 2) Japanese Black cattle presented with bilateral rostral mandibular open fractures. At presentation, the proximal edges of each fracture were discolored and had a severe stench, indicating necrosis caused by infection. In both cases, a bilateral rostral mandibulectomy over the symphysis was performed. Although the tongues of both animals prolapsed post-surgery, they had no significant problems with eating or drinking. Case 1 showed excellent growth during fattening, and Case 2 successfully became pregnant and gave birth. Rostral mandibulectomy can be an effective surgical option for the treatment of cattle with difficulty in internal or external fixation due to unfavorable necrotic cranial mandibular open fractures.</p>

    DOI: 10.1292/jvms.19-0160

    PubMed

    CiNii Article

  • Des-acyl ghrelin prevents heatstroke-like symptoms in rats exposed to high temperature and high humidity

    Inoue Y., Hayashi Y., Kangawa K., Suzuki Y., Murakami N., Nakahara K.

    Neuroscience Letters   615   28 - 32   2016年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Neuroscience Letters  

    © 2016 Elsevier Ireland Ltd. We have shown previously that des-acyl ghrelin decreases body temperature in rats through activation of the parasympathetic nervous system. Here we investigated whether des-acyl ghrelin ameliorates heatstroke in rats exposed to high temperature. Peripheral administration of des-acyl ghrelin significantly attenuated hyperthermia induced by exposure to high-temperature (35°C) together with high humidity (70-80%). Although biochemical analysis revealed that exposure to high temperature significantly increased hematocrit and the serum levels of aspartate amino transferase (AST), alanine transaminase (ALT), blood urea nitrogen (BUN), creatinine and electrolytes (Na+, K+, Cl-), most of these heatstroke-associated reactions were significantly reduced by treatment with des-acyl ghrelin. The level of des-acyl ghrelin in plasma was also found to be significantly increased under high-temperature conditions. These results suggest that des-acyl ghrelin could be useful for preventing heatstroke under high temperature condition.

    DOI: 10.1016/j.neulet.2016.01.003

    Scopus

    PubMed

  • Changes in mRNA expression of arcuate nucleus appetite-regulating peptides during lactation in rats

    Suzuki Y., Nakahara K., Maruyama K., Okame R., Ensho T., Inoue Y., Murakami N.

    Journal of Molecular Endocrinology   52 ( 2 )   97 - 109   2013年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Molecular Endocrinology  

    The contribution of hypothalamic appetite-regulating peptides to further hyperphagia accompanying the course of lactation in rats was investigated by using PCR array and real-time PCR. Furthermore, changes in the mRNA expression for appetite-regulating peptides in the hypothalamic arcuate nucleus (ARC) were analyzed at all stages of pregnancy and lactation, and also after weaning. Food intake was significantly higher during pregnancy, lactation, and after weaning than during non-lactation periods. During lactation, ARC expression of mRNAs for agouti-related protein (AgRP) and peptide YY was increased, whereas that of mRNAs for proopiomelanocortin (POMC) and cholecystokinin (CCK) was decreased, in comparison with non-lactation periods. The increase in AgRP mRNA expression during lactation was especially marked. The plasma level of leptin was significantly decreased during the course of lactation, whereas that of acyl-ghrelin was unchanged. In addition, food intake was negatively correlated with the plasma leptin level during lactation. This study has clarified synchronous changes in the expression of many appetite-regulating peptides in ARC of rats during lactation. Our results suggest that hyperphagia during lactation in rats is caused by decreases in POMC and CCK expression and increases in AgRP expression in ARC, the latter being most notable. Together with the decrease in the blood leptin level, such changes in mRNA expression may explain the further hyperphagia accompanying the course of lactation. © 2014 The authors Published by Bioscientifica Ltd.

    DOI: 10.1530/JME-13-0015

    Scopus

    PubMed

  • Central and peripheral des-acyl ghrelin regulates body temperature in rats

    Inoue Y., Nakahara K., Maruyama K., Suzuki Y., Hayashi Y., Kangawa K., Murakami N.

    Biochemical and Biophysical Research Communications   430 ( 1 )   278 - 283   2013年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biochemical and Biophysical Research Communications  

    In the present study using rats, we demonstrated that central and peripheral administration of des-acyl ghrelin induced a decrease in the surface temperature of the back, and an increase in the surface temperature of the tail, although the effect of peripheral administration was less marked than that of central administration. Furthermore, these effects of centrally administered des-acyl ghrelin could not be prevented by pretreatment with [D-Lys3]-GHRP-6 GH secretagogue receptor 1a (GHS-R1a) antagonists. Moreover, these actions of des-acyl ghrelin on body temperature were inhibited by the parasympathetic nerve blocker methylscopolamine but not by the sympathetic nerve blocker timolol. Using immunohistochemistry, we confirmed that des-acyl ghrelin induced an increase of cFos expression in the median preoptic nucleus (MnPO). Additionally, we found that des-acyl ghrelin dilated the aorta and tail artery in vitro. These results indicate that centrally administered des-acyl ghrelin regulates body temperature via the parasympathetic nervous system by activating neurons in the MnPO through interactions with a specific receptor distinct from the GHS-R1a, and that peripherally administered des-acyl ghrelin acts on the central nervous system by passing through the blood-brain barrier, whereas it exerts a direct action on the peripheral vascular system. © 2012 Elsevier Inc.

    DOI: 10.1016/j.bbrc.2012.10.137

    Scopus

    PubMed

  • Transitional change in rat fetal cell proliferation in response to ghrelin and des-acyl ghrelin during the last stage of pregnancy 査読あり

    Y Inoue, K Nakahara, K Kangawa, N Murakami

    Biochemical and Biophysical Research Communications   2010年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

講演・口頭発表等 【 表示 / 非表示

  • 頚長筋における化膿性肉芽腫性筋炎と診断された犬の1例

    井上賀之,中村健介,水谷祐子,高木千尋,Naik Mrunmayi Vishwanath,Kim Su Eun,土本彩花,城戸 洋,二瓶和美,日高勇一

    第16 回日本獣医内科学アカデミー学術大会 

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    開催年月日: 2020年2月

    記述言語:日本語   会議種別:口頭発表(一般)  

  • 先天性リンパ水腫と診断した黒毛和種牛の1例

    土本彩花,桐野有美,山内詩乃,柳 祐介,Naik Mrunmayi Vishwanath,Kim Su Eun,佐藤裕之,山口良二,保田昌宏,井上賀之,日高勇一

    日本産業動物獣医学会九州地区 

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    開催年月日: 2019年11月8日

    記述言語:日本語   会議種別:口頭発表(一般)  

  • 椎孔内浸潤を示した犬のダンベル型悪性末梢神経鞘腫瘍の1例

    今富美波,平井卓哉,井上賀之,山口良二

    日本小動物獣医学会九州地区 

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    開催年月日: 2019年11月8日

    記述言語:日本語   会議種別:口頭発表(一般)  

  • 環椎、軸椎の形態異常に伴う四肢不全麻痺を呈した猫1例に対する外科的治験例

    井上賀之,土本彩花,水谷真也,水谷祐子,Naik Mrunmayi Vishwanath,坂井秀二,桐野有美,日高勇一

    日本小動物獣医学会九州地区 

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    開催年月日: 2019年11月8日

    記述言語:日本語   会議種別:口頭発表(一般)  

  • 内固定および外固定を併用して治療した踵骨骨折の黒毛和種子牛の1例

    井上賀之,加藤梨帆,茂木渉,Naik Mrunmayi Vishwanath,Kim Su Eun,桐野有美,日高 勇一

    日本産業動物獣医学会九州地区 

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    開催年月日: 2019年11月8日

    記述言語:日本語   会議種別:口頭発表(一般)  

全件表示 >>

受賞 【 表示 / 非表示

  • 産業動物獣医学会九州獣医師連合会会長賞

    2019年11月   日本産業動物獣医学会   内固定および外固定を併用して治療した踵骨骨折の黒毛和種子牛の1例

    井上賀之,加藤梨帆,茂木渉,Naik Mrunmayi Vishwanath,Kim Su Eun,桐野有美,日高 勇一

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    受賞区分:国内学会・会議・シンポジウム等の賞  受賞国:日本国

  • 小動物獣医学会フレッシャーアワード

    2019年11月   日本小動物獣医学会  

    井上賀之,土本彩花,水谷真也,水谷祐子,Naik Mrunmayi Vishwanath,坂井秀二,桐野有美,日高勇一

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    受賞区分:国内学会・会議・シンポジウム等の賞  受賞国:日本国

  • 日本産業動物獣医学会九州地区連合会長賞

    2017年10月   日本獣医産業動物獣医学会   両側下顎骨開放骨折に対し吻側下顎骨切除術を行った黒毛和種子牛の1例

    西川豪亜, 日高勇一, 岩本希生, Naik Mrunmayi Vishwanath, 山部竜正, 都築 直, 桐野有美, 井上賀之

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    受賞区分:国内学会・会議・シンポジウム等の賞  受賞国:日本国

科研費(文科省・学振)獲得実績 【 表示 / 非表示

  • デスアシルグレリンの新規生理作用の探索ならびに受容体の同定

    2011年04月 - 2013年03月

    科学研究費補助金  特別研究員奨励費