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Affiliation |
Faculty of Medicine College Hospital Medicine |
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Title |
Professor |
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External Link |
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IKEDA Ryuji
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Papers 【 display / non-display 】
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Retrospective analysis of the correlation between tacrolimus concentrations measured in whole blood and variations of blood cell counts in patients undergoing allogeneic haematopoietic stem cell transplantation. Reviewed
Yoshikawa N, Urata S, Yasuda K, Sekiya H, Hirabara Y, Okumura M, Ikeda R.
Eur J Hosp Pharm 2020.3
Language：English Publishing type：Research paper (scientific journal)
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Anti-proliferative Activities of Some Bivalent Symmetrical 5-Substituted Hydantoin Derivatives towards Human Brain Glioma U251 Cells (U251) and Human Carcinoma Cells (KB3-1). Reviewed
Furutachi M, Ota K, Fujisaki F, Ikeda R, Yoshikawa N, Yokota T, Takeda Y, Yokomizo K, Zhou JR, Kashige N, Miake F, Sumoto K.
Biol Pharm Bull. 2019.11
Language：English Publishing type：Research paper (scientific journal)
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医薬品SPDを活用したタスク・シフティングの検討 Reviewed
関屋裕史、友宗直樹、緒方豊、梶原隆広、福永洋子、森木豊栄、長友隆雄、岩田円夏、萩原櫻子、池田 龍二
九州薬学会雑誌 2019.11
Language：Japanese Publishing type：Research paper (scientific journal)
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当院の持参薬鑑別時におけるお薬手帳の利用状況とお薬手帳の記載内容調査 Reviewed
外山智章、畑中真理、田﨑智也、竹島秀美、平原康寿、池田 龍二
九州薬学会雑誌 2019.11
Language：Japanese Publishing type：Research paper (scientific journal)
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電子カルテシステムのベンダー変更を契機としたがん薬物療法レジメンの見直しと医療安全に向けた取り組み Reviewed
浦田修平、大野梨絵、千阪智美、北畑恵理子、髙橋沙季、是枝秀彦、森山徳文、平原康寿、池田 龍二
九州薬学会雑誌 2019.11
Language：Japanese Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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臨床薬学テキストシリーズ 循環器／腎・泌尿器／代謝／内分泌：「第3章代謝性疾患-B疾患各論-③脂質異常症」
武田泰生、池田龍二、石橋俊（ Role： Joint author）
中山書店 2020.1
Language：Japanese Book type：Textbook, survey, introduction
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The dynamics of social capital and civic engagement in Asia
Daniere Amrita, Luong Hy V.
Routledge 2012
Language：Japanese
MISC 【 display / non-display 】
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Owatari S., Akune S., Komatsu M., Ikeda R., Firth S., Che X., Yamamoto M., Tsujikawa K., Kitazono M., Ishizawa T., Takeuchi T., Aikou T., Mercer J., Akiyama S., Furukawa T.
Cancer Research 67 ( 13 ) 2007.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Cancer Research
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Inoue I., Ikeda R., Tsukahara S.
Journal of Pharmacological Sciences 100 ( 3 ) 205 - 210 2006.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Journal of Pharmacological Sciences
To understand the molecular pathogenesis of ossification of the posterior longitudinal ligament of the spine (OPLL), an ectopic bone formation disease, we performed cDNA microarray analysis on cultured ligament cells from OPLL patients to understand the molecular pathogenesis of OPLL. We identified promyelotic leukemia zinc finger (PLZF) as one of up-regulated genes and tumor necrosis factor-α-stimulated gene 6 (TSG-6) as one of down-regulated gene during osteoblastic differentiation. We investigated the roles of PLZF in the regulation of osteoblastic differentiation of human mesenchymal stem cells (hMSCs) and C2C12 cells. siRNA-mediated gene-silencing of PLZF resulted in a reduction of the expression of osteoblast-specific genes such as the alkaline phosphatase, collagen 1A1, Runx2/CBFA1, and osteocalcin genes in the presence of osteogenic differentiation medium (OS) in hMSCs. The overexpression of PLZF induced CBFA1 induction, suggesting that PLZF is an upstream regulator of CBFA1 and thereby participates in promoting the ossification of spinal ligament cells in OPLL patients. Adenoirus-mediated TSG-6 overexpression in hMSCs resulted in suppression of oseoblastic differentiation induced by either BMP-2 or OS. TSG-6 can bind to BMP-2 directly and thereby could inhibit BMP-2 signaling. Taken together, these findings indicate that PLZF and TSG-6 play important roles in early osteoblastic differentiation. ©2006 The Japanese Pharmacological Society.
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Okumura H., Chen Z., Sakou M., Sumizawa T., Furukawa T., Komatsu M., Ikeda R., Suzuki H., Hirota K., Aikou T., Akiyama S.
Molecular Pharmacology 58 ( 6 ) 1563 - 1569 2000
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Molecular Pharmacology
A newly synthesized taxoid originally from the Japanese yew Taxus cuspidata, 5-O-benzoylated taxinine K (BTK) was examined for its ability to reverse P-glycoprotein (P-gp) and multidrug resistance protein (MRP)-mediated multidrug resistance. BTK reversed the resistance to paclitaxel, doxorubicin (ADM), and vincristine (VCR) of KB-8-5 and KB-C2 cells that overexpress P-gp by directly interacting with P-gp. BTK also moderately reversed the resistance to ADM of KB/MRP cells that overexpress MRP. However, BTK neither inhibited the transporting activity of MRP nor reduced intracellular glutathione levels in KB/MRP cells. BTK shifted the distribution of ADM in KB/MRP cells from punctate cytoplasmic compartments to the nucleoplasm and cytoplasm by inhibiting acidification of cytoplasmic organelles. These two functions of BTK make it able to reverse both P-gp- and MRP-mediated MDR. BTK in combination with ADM should be useful for treating patients with tumors that overexpress both P-gp and MRP.
Presentations 【 display / non-display 】
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MAC 治療薬の併用開始が抗てんかん薬の薬物体内動態に影響を及ぼした1症例：フェニトイン血中濃度の変動
吉川直樹、田﨑智也、園田純一郎、畑中真理、小田康晴、松元信弘、池田龍二
第40回日本臨床薬理学会学術総会
Event date： 2019.12.4 - 2019.12.6
Language：Japanese Presentation type：Poster presentation
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5-Aza-2-deoxycytidine enhances the sensitivity of 5-fluorouracil by demethylation of SP-1 binding site on Thymidine phosphorylase promoter
Yukihiko Nishizawa，Ryuji Ikeda，Masatatsu Yamamoto，Kohichi Kawahara，Yoshinari Shinsato，Kentaro Minami，Mina Nitta，Hideyuki Terazono，Shin-ichi Akiyama，Tatsuhiko Furukawa，Yasuo Takeda
第29回日本医療薬学会年会
Event date： 2019.11.2 - 2019.11.4
Language：English Presentation type：Poster presentation
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後発医薬品導入におけるカットオフ値の重要性と医療経済効果
関屋裕史、緒方豊、梶原隆広、福永洋子、森木豊栄、池田龍二
第29回日本医療薬学会年会
Event date： 2019.11.2 - 2019.11.4
Language：Japanese Presentation type：Oral presentation (general)
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A retrospective study of urine dipstick analysis and urine protein/creatinine ratio for monitoring proteinuria during anti-VEGF therapy
Shuhei Urata，Nobuhiro Shibata，Rie Ohno，Yasutoshi Hirabara，Ryuji Ikeda： A retrospective study of urine dipstick analysis and urine protein/creatinine ratio for monitoring proteinuria during anti-VEGF therapy
第29回日本医療薬学会年会
Event date： 2019.11.2 - 2019.11.4
Language：English Presentation type：Poster presentation
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AMR 対策アクションプランに向けた抗菌薬適正使用推進と今後の対策
外山智章、平原康寿、岩尾千紘、中山雄貴、荒武舞、山田明輝、高城一郎、岡山昭彦、池田龍二
第29回日本医療薬学会年会
Event date： 2019.11.2 - 2019.11.4
Language：Japanese Presentation type：Poster presentation
Grant-in-Aid for Scientific Research 【 display / non-display 】
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がん組織における心筋特異的トロポニンT発現の病態生理学的意義
Grant number：22K08128 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
鶴田 敏博、
Authorship：Coinvestigator(s)
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実践的看護臨床薬理学教育モデル（iDrug）に基づいた新たな教育システムの開発
Grant number：21H03223 2021.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
柳田 俊彦、
Authorship：Coinvestigator(s)
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オートファジー細胞死を標的とする新規肺腺癌治療薬の開発
Grant number：21K06691 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
南 謙太朗、
Authorship：Coinvestigator(s)