Papers - IKEDA Ryuji
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Ikeda R., Nagao T., Okabe H., Nakano Y., Matsunaga H., Katano M., Mori M.
Chemical and Pharmaceutical Bulletin 46 ( 5 ) 871 - 874 1998.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Chemical and Pharmaceutical Bulletin
The MeOH extract of the root and the ground part of Anthriscus sylvestris HOFFM. showed a high inhibitory activity against MK-1, HeLa, and B16F10 cell growth in vitro. The activity was found only in the CHCl3- soluble fractions. From the CHCl3-soluble fraction of the root, falcarindiol, 1-(3'-methoxy-4',5'-methylenedioxyphenyl)-1ζ- methoxy-2- propene, elemicin, and nemerosin were newly isolated in addition to deoxypodophyllotoxin (anthricin), anthriscusin, (-)-deoxypodorhizone, and anthriscinol methyl ether which were reported earlier as constituents of the root of this plant. From the CHCl3-soluble fraction of the ground part, deoxypodophyllotoxin, (-)-deoxypodorhizone, nemerosin, and falcarindiol were isolated. In vitro antiproliferative activities of the isolates against MK- 1, HeLa, and B16F10 cells are reported.
DOI： 10.1248/cpb.46.871
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Ikeda R., Nagao T., Okabe H., Nakano Y., Matsunaga H., Katano M., Mori M.
Chemical and Pharmaceutical Bulletin 46 ( 5 ) 875 - 878 1998.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Chemical and Pharmaceutical Bulletin
The constituents in the fruit of Anthriscus sylvestris HOFFM. were investigated, and four lignans [deoxypodophyllotoxin, morelensin, (-)- deoxypodorhizone, and (-)-hinokinin], one phenylpropanoid [l-(3',4'- dimethoxyphenyl)-1ζ-hydroxy-2-propene], two phenylpropanoid esters [3',4'- dimethoxycinnamyl (z)-2-angeloyloxymethyl-2-butenoate and 3',4'- dimethoxycinnamyl (Z)-2-tigloyloxymethyl-2-butenoate], and one polyacetylenic compound (falcarindiol) were isolated. Their antiproliferative activity against MK-1, HeLa and B16F10 cell lines is reported.
DOI： 10.1248/cpb.46.875